Search Results
Monday, December 15th, 2025
(Beyond Pesticides, December 15, 2025) With recent proposals by the U.S. Environmental Protection Agency (EPA) to register new pesticides that under international standards are classified as PFAS (Per- and Polyfluoroalkyl Substances), people and organizations are calling for Congress to reverse the agencyâs action. Beyond Pesticides announced an action to Tell EPA and Congress to eliminate PFAS chemicals, including those used in pesticides. In its action Beyond Pesticides pointed to the long history of allowing pesticides on that market that have long residual lives and bioaccumulate in the environment, causing generations of exposure and adverse effects to health and ecosystems. DDT (Dichlorodiphenyltrichloroethane) exemplifies the generational effect of a toxic pesticide whose effects ha endured for decades, even though it was hailed as a miracle solution for agriculture and public health. PFAS, with a wide variety of usesâfrom nonstick pans to waterproofing fabrics to firefighting foams to pesticidesâmight similarly lead to the characterization as a âmiracleâ chemical. PFAS also share the less beneficial characteristics of DDT. Like DDT, PFAS are persistent, leading to the nickname âforever chemicals,â and they are highly toxic. EPA links PFAS to an increased risk of many health effects, including decreased fertility and hypertension in pregnant people; increased risk of prostate, […]
Posted in Biosolids, Centers for Disease Control and Prevention (CDC), Endocrine Disruption, Environmental Protection Agency (EPA), Fertilizer, PFAS, Sewage Sludge, Take Action, Toxic Waste, Uncategorized | No Comments »
Friday, December 12th, 2025
(Beyond Pesticides, December 12, 2025) A study concluding that the weed killer glyphosate did not cause cancer was retracted last week after it was revealed in lawsuit documents that the authors did not disclose their relationship with Monsanto/Bayer. The editor-and-chief, Martin van den Berg, PhD of Regulatory Toxicology and Pharmacology, which published the article 25 years ago, wrote in the journal, âConcerns were raised regarding the authorship of this paper, validity of the research findings in the context of misrepresentation of the contributions by the authors and the study sponsor and potential conflicts of interest of the authors.â The study, titled âSafety Evaluation and Risk Assessment of the Herbicide Roundup and Its Active Ingredient, Glyphosate, for Humansâ and coauthored by three researchers in New York, The Netherlands, and Canada, was referred to as a âLandmark glyphosate safety studyâ in a recent article by U.S. Right to Know.  While this retraction not only sheds light on Monsantoâs influence through ghostwriting, it adds to the wide body of evidence regarding the regulatory deficiencies currently in place. The revelation is a reminder of related incidents in which Monsanto (Bayer) and other companies have wielded excessive influence at the U.S. Environmental Protection Agency (EPA), undermining the integrity of the science needed to inform the regulatory decisions that safeguard health and the environment. (See Daily News Corruption Problems Persist at EPA.) EPA Deficiencies In addition to the initial registration process, the Federal Insecticide, Fungicide, and Rodenticide Act (FIFRA) requires that EPA conduct a registration review of all pesticide […]
Posted in Agriculture, Alternatives/Organics, Bayer, Environmental Protection Agency (EPA), Glyphosate, Herbicides, Monsanto, Pesticide Regulation | No Comments »
Wednesday, December 10th, 2025
(Beyond Pesticides, December 10, 2025) On November 21, 2025, the International Agency for Research on Cancer (IARC), a branch of the World Health Organization (WHO), designated the endocrine-disrupting herbicide atrazine (as well as the herbicide alachlor) as âprobably carcinogenic to humans.â Manufactured by the multinational, China-based pesticide corporation Syngenta, atrazine has been linked to various adverse health effects and runoff into waterways across the continental United States for years. Tyrone Hayes, PhD, researcher and professor of Integrative Biology at the University of California, Berkeley, who studies the endocrine-disrupting properties of atrazine and other chemicals, has said that atrazine induces cancer by turning on the enzyme aromatase. Dr. Hayes told conferees of Beyond Pesticidesâ 31st National Pesticide Forum that: â[W]hat is concerning about aromatase expression and estrogen in mammals is breast cancer and prostate cancer. With regard to prostate cancer, there is an 8.4-fold increase in prostate cancer in men who work in atrazine factories and bag atrazine. There is at least one correlational study, which I didnât publish, that shows women whose well water is contaminated with atrazine are more likely to develop breast cancer than women who live in the same community, but donât drink the well water. (Kettles, […]
Posted in Atrazine, Breakdown Chemicals, Cancer, hydroxyatrazine, non-Hodgkin's Lymphoma, Syngenta, Uncategorized, World Health Organization | No Comments »
Thursday, December 4th, 2025
(Beyond Pesticides, December 4, 2025) In a news release last week on November 26, 2025, the U.S. Environmental Protection Agency (EPA) âissued a comprehensive fact-check addressing dangerous misinformation circulating about EPA’s recent pesticide approvalsâ that, according to health and environmental advocates, continues to deceive the public about the true risks for health and the environment from petrochemical pesticides including, but not limited to, per- and polyfluoroalkyl substances (PFAS). Also published on November 26, coverage titled The EPA Is Embracing PFAS Pesticides. These Are The Health Risks in Time further highlights EPAâs deficiencies and the threats of PFAS, which Beyond Pesticides has extensively covered. (See here and here.) The controversy erupted as a result of EPAâs latest proposal to allow a new fluorinated pesticide to the list of four other similar compounds now widely available for use in homes and gardens, buildings, and agriculture. The newest pesticide proposed for EPA registration, epyrifenacil (agricultural weed killer), joins cyclobutrifluram (soil fungicide/nematicide), isocycloseram (household and agricultural insecticide), diflufenican (lawn and agricultural weed killer), and trifludimoxazin (agricultural weed killer), making a total of five PFAS pesticide proposals this year that have been associated with national and worldwide contamination of food, land, and water. Two of these, cyclobutrifluram and isocycloseram, have been approved. âInstead of constraining the use of fluorinated pesticidesâpersistent and highly toxic […]
Posted in Agriculture, Cancer, contamination, Developmental Disorders, Environmental Protection Agency (EPA), Epigenetic, Immunotoxicity, International, Pesticide Regulation, PFAS | 1 Comment »
Tuesday, December 2nd, 2025
(Beyond Pesticides, December 2, 2025) Recently published in Reproductive Toxicology, researchers in Denmark and Iceland investigate the impacts of pesticides on sex hormones, finding that âprenatal exposure to [the insecticide] chlorpyrifos and [weed killer] 2,4-D may affect the reproductive hormones in girls, but not boys, during minipuberty, which may have long-term implications.â Based on their analysis of urinary maternal concentrations of the pesticides and their metabolites and hormone levels in infants, the authors report, âThis study examined the association between maternal pesticide exposure and pituitary, gonadal, and adrenal hormones in offspring during infancy.â The sex-specific findings highlight a public health concern with potentially long-lasting transgenerational effects. âWe recruited pregnant women from 2010 to 2012 in the Odense Child Cohort, including 489 mother-child pairs,â the authors state. They continue: âMaternal urinary concentrations of the generic pyrethroid metabolite 3-phenoxybenzoic acid (3-PBA), the chlorpyrifos metabolite 3,5,6-trichloro-2-pyridinol (TCPY), and the herbicide 2,4-D were measured at gestational week 28. Serum concentrations of luteinizing hormone (LH), follicle stimulating hormone (FSH), testosterone (T), estrone (E1), estradiol (E2), 17-hydroxyprogesterone (17-OHP), Androstenedione (Adione), and Dehydroepiandrosterone sulfate (DHEAS) were assessed in infancy.â The results of the analyses show that in girls, higher maternal urinary TCPY and 2,4-D concentrations are significantly […]
Posted in 2,4-D, Agriculture, Biomonitoring, Children, Chlorpyrifos, Endocrine Disruption, Metabolites, pyrethroids, Reproductive Health, Synthetic Pyrethroid, Women's Health | No Comments »
Tuesday, November 25th, 2025
(Beyond Pesticides, November 25, 2025) Chemical pollution is having a profound impact on menâs overall health and reproductive function. Endocrine-disrupting chemicalsâwhich prominently include pesticidesâare a major factor. The Health and Environment Alliance (HEAL) a European organization funded by the European Union (EU) and several private foundations, has issued a strong call for attention to â and action on â the precipitous decline in male reproductive health owing to chemical exposures, including pesticides. In a new report, Chemical pollution and menâs health: A hidden crisis in Europe, the group states, âThe scientific evidence is clear. The costs of chemical pollution â human and economic â are mounting. The solutions exist. What we need now is the political will to act.â The report was written by Rosaella Cannarella, M.D., PhD, an endocrinologist at the Division of Endocrinology, Metabolic Diseases and Nutrition, University of Catania (Italy). HEALâs report details alarming indications of catastrophe in male reproductive health: prostate cancer, testicular cancer, crashing sperm counts, and numerous developmental problems including cryptorchidism, urogenital malformations, and hypospadias. The report highlights pesticides, microplastics, phthalates, bisphenols, PFAS and heavy metals as the likely environmental sources of the crisis. There is evidence that all of these endocrine disrupting chemicals […]
Posted in Agriculture, Belgium, Canada, Cancer, European Union, Glyphosate, Infertility, International, Italy, Prostate Cancer, Rwanda, Testicular Cancer, Uncategorized | No Comments »
Thursday, November 20th, 2025
(Beyond Pesticides, November 20, 2025) Recent scientific literature finds heightened toxicity associated with pesticide metabolites, the transformation/breakdown products of the parent compounds, that threaten the health of the soil, wildlife, and humans. This research stresses the importance of the U.S. Environmental Protection Agency (EPA) evaluating metabolites, which is currently insufficiently included in regulatory processes. In a literature review in Global Change Biology, the researchers point out multiple areas in which regulations fail to address key criteria, including metabolites, saying: âPesticide risk assessments currently rely on surrogate species and focus primarily on acute lethality metrics, failing to capture the broader impacts on non-target organisms and thus biodiversity. Under the directives of regulatory agencies worldwide, this traditional approach overlooks the complex interactions between multiple stressors, including climate change, land-use shifts, and pesticide transformation products. Pesticide risk assessments must therefore undergo a paradigm shift to account for these complex interactions, which disproportionately affect insect pollinators, other non-target species, and biodiversity at large.â A metabolite is a breakdown product that forms when a pesticide is used in the environment and mixes with air, water, soil, or living organisms. All metabolites fall under the category of transformation products, which is the broader term for any […]
Posted in Agriculture, Biodiversity, Breakdown Chemicals, Chlorothalonil, Environmental Protection Agency (EPA), Imidacloprid, Insecticides, Metabolites, neonicotinoids, organophosphate, Pollinators, Seeds | No Comments »
Friday, November 14th, 2025
(Beyond Pesticides, November 14, 2025) A literature review in Ecotoxicology and Environmental Safety finds a sex-specific relationship between pesticide exposure and thyroid cancer, with heightened risks for women. âThyroid cancer (TC) is one of the most common endocrine malignancies worldwide, yet the association between pesticide exposure and TC has not been systematically summarized,â the authors state. âThis study aimed to elucidate the relationship between pesticide exposure and TC, focusing on insecticides, herbicides, and fungicides.â In the U.S., approximately 44,020 new cases and 2,290 deaths are estimated for 2025, according to the American Cancer Society, with thyroid cancer as the ninth most common cancer in women. (See research here.) TC ranks globally as the tenth most common cancer, representing a worldwide threat to both men and women. (See here.) The current study considers scientific literature on thyroid cancer and pesticide exposure by pesticide type to extract data and statistically analyze the link between exposure and risk of TC. The results indicate a positive association between exposure to insecticides, herbicides, and fungicides and thyroid cancer, with the sex-based analysis revealing the risk of TC is higher in females. Study Background and Importance As the researchers write, thyroid cancer âis one of the […]
Posted in Biomonitoring, Cancer, Endocrine Disruption, Endosulfan, Fungicides, Herbicides, Insecticides, Malathion, Oxidative Stress, Thyroid Disease, Women's Health | No Comments »
Tuesday, November 11th, 2025
(Beyond Pesticides, November 11, 2025) A study published in Cardiovascular Toxicology (July 2025) finds significant associations between Gulf War deployment-related toxic chemical exposure hazards and various adverse health outcomes, including heightened risk of atherosclerotic cardiovascular diseases (ASCVDs), such as âheart attack, coronary heart disease, stroke, transient ischemic attack, and peripheral vascular disease.â While there were no significant associations found directly between pesticide products and these adverse health effects, researchers attribute this to limited sample sizes and wide confidence intervals as part of the study methodology. Further research is necessary to build on this study, given the preponderance of scientific evidence linking pesticide exposure to heightened health risks to the cardiovascular system. On the issue of statistical significance, the authors state the following: âThere may be difficulty [for survey respondents] remembering the[ir] military exposure history since the survey was completed nearly 25 years after the Gulf War.â While it is difficult to pinpoint pesticide exposure as a cause of illness among the toxic mixtures to which service members are exposed, there has been recognition by the Veterans Administration (VA) of diseases that are directly related to military service. Beyond Pesticides previously reported that the VA has established 20 burn pit and […]
Posted in Blood Disorders, Cardiovascular Disease, Chemical Mixtures, Disease/Health Effects, Environmental Justice, Federal Agencies, Uncategorized, Veterans Administraton | No Comments »
Friday, November 7th, 2025
(Beyond Pesticides, November 7, 2025)Â There is little dispute that modern industrial culture has produced a constellation of related chronic conditions contributing powerfully to human disease. In recent decades, attention has begun to focus on the developmental origins of health and diseaseâprenatal exposures to pesticides, for example, that contribute to diseases in adulthood, such as cardiovascular and metabolic problems, along with the combination, known as cardiometabolic syndrome. Cardiometabolic disorders include obesity, hypertension, cholesterol imbalances, and insulin resistance. The usual suspects blamed for the syndrome are poor diet, physical inactivity, and genetic predisposition. These are all well-established risk factors, but they fail to fully account for the sharp rise in cardiometabolic syndrome globally. Obesity prevalence has doubled and diabetes quadrupled over the last 40 years, according to the Non-Communicable Diseases (NCD) Risk Factor Collaboration. In a study on early life exposure to a pesticide mixture, researchers analyze sex differences in cardiometabolic outcomes from prenatal and early life. The study was conducted by an international team of scientists led by Ana M. Mora, M.D., of the Center for Environmental Research and Community Health at the University of California, Berkeley, using data from the Center for the Health Assessment of Mothers and Children of […]
Posted in Agriculture, Children, Glyphosate, Malathion, metabolic syndrome, Obesity, organophosphate, Permethrin, pyrethroids, Uncategorized | No Comments »
Thursday, October 30th, 2025
(Beyond Pesticides, October 29, 2025) A study published in Environment International evaluates residues of individual and mixtures of endocrine-disrupting chemicals (EDCs), including pesticides, and finds an association between exposure and hyperactive behavior in children. The researchers evaluated urine samples from over 800 preschoolers, identifying and statistically analyzing concentrations of 22 EDCs, and finding that nine of these chemicals are significantly associated with hyperactivity trajectories and EDC mixtures are positively associated with hyperactive behavior, noting the strongest association in girls. âThe current study indicates the adverse health effects of exposure to mixtures of EDCs among preschoolers, and suggests gender specificity in these effects,â the researchers state. They continue, âThis highlights the importance of focusing on multi-pollutant exposure in early childhood.â Study Importance âAttention-deficit/hyperactivity disorder (ADHD) is a common neurodevelopmental disorder in children, which has become one of the main factors leading to the burden of disease in children and adolescents worldwide.â The authors continue: âIts core symptoms are high levels of inattention and/or hyperactivity/impulsivity during the preschool period. A meta-analysis showed that the overall prevalence of ADHD in children in China over the past 15 years was as high as 6.2%, and has been increasing over recent years.â In comparison, according […]
Posted in ADHD, Biomonitoring, Body Burden, Chemical Mixtures, Children, Children/Schools, Endocrine Disruption, Pesticide Mixtures, PFAS | No Comments »
Tuesday, October 21st, 2025
(Beyond Pesticides, October 21, 2025) A study, published in International Journal of Hygiene and Environmental Health, calculates cumulative dietary pesticide exposure and finds a significant positive association between pesticide residues in food and urine when analyzing over 40 produce types. The research uses data for 1,837 individuals from the 2015â2016 National Health and Nutrition Examination Survey (NHANES) and compares them to biomonitoring samples of the participants. According to the researchers, âHere we show that consumption of fruits and vegetables, weighted by pesticide load, is associated with increasing levels of urinary pesticide biomarkers.â They continue, âWhen excluding potatoes, consumption of fruits and vegetables weighted by pesticide contamination was associated with higher levels of urinary pesticide biomarkers for organophosphate, pyrethroid, and neonicotinoid insecticides.â The NHANES data is derived from a national biomonitoring survey from the U.S. Centers for Disease Control and Prevention (CDC), which collects information about consumption of fruits and vegetables as well as urine samples. Background As the study authors explain: âHundreds of millions of pounds of synthetic pesticide active ingredients are used every year in the United States, and pesticide exposure can occur through food, drinking water, residential proximity to agricultural spraying, household pesticide use, and occupational use. Pesticide […]
Posted in Agriculture, Alternatives/Organics, Azoxystrobin, Biomonitoring, Body Burden, boscalid, Centers for Disease Control and Prevention (CDC), fludioxonil, Imidacloprid, neonicotinoids, organophosphate, Pesticide Mixtures, Pesticide Regulation, Pesticide Residues, pyraclostrobin, pyrethroids, synergistic effects, Synthetic Pyrethroid, thiabendazole | No Comments »
Wednesday, October 15th, 2025
(Beyond Pesticides, October 15, 2025) The latest Scientific Investigations Report for 2025 from the U.S. Geological Survey (USGS), entitled âNational Water Quality Program: Multidecadal Change in Pesticide Concentrations Relative to Human Health Benchmarks in the Nationâs Groundwater,â finds moderate concentrations of five pesticides, with the highest percentages in agricultural wells, and concentrations of the carcinogenic soil fumigant DBCP (1,2-dibromo-3-chloropropane), which also causes infertility, that are greater than the maximum containment level, despite being banned over 45 years ago. These results highlight the persistence of pesticides used in agriculture and the elevated risks of pesticide contamination in agricultural areas. This report monitors concentrations of pesticides in well networks across the U.S. in decadal intervals, with this last one incorporating data ranging from 1993-2023. Additionally, DBCP in one well network in the San Joaquin-Tulare River Basin in California continues to be assessed due to previous levels exceeding the human health benchmark (HHB) established by the U.S. Environmental Protection Agency (EPA). The limitations of the study are disclosed in the text of the report. As the authors state: âOnly pesticides with an HHB were included in the multidecadal pesticide change analysis… The total number of pesticides included in this study is less than […]
Posted in Agriculture, Alachlor, Atrazine, California, contamination, DBCP, deethylatrazine, Drinking Water, Groundwater, Pesticide Mixtures, Prometon, simazine, synergistic effects, U.S. Geological Survey, Water | 1 Comment »
Wednesday, October 1st, 2025
(Beyond Pesticides, October 1, 2025) A novel study in Scientific Reports combines computational analyses with toxicological data to identify pathways affected by exposure to the weed killer glyphosate. The analyses identify glyphosate targets that correlate with kidney injury and kidney cancer, revealing pathways with significant glyphosate-induced alterations, including the dysregulation of nitrogen metabolism that leads to ammonia accumulation and oxidative stress, both of which contribute to renal (kidney) damage and carcinogenesis (development of cancer). âThis study provides a comprehensive investigation into the molecular mechanisms by which glyphosate may contribute to kidney injury and kidney cancer, employing an array of bioinformatics tools for target prediction, toxicity assessment, pathway enrichment analysis, molecular docking and molecular dynamics simulation,â the researchers state. The results of the analyses and simulations highlight the molecular mechanisms underlying glyphosate’s nephrotoxic (damaging to kidneys) and carcinogenic (cancer-causing) effects. Study Importance and Background Glyphosate, known as a broad-spectrum systemic herbicide, has been used for agricultural and nonagricultural purposes for decades and is the most extensively used herbicide worldwide. This widespread use is largely due to its application to genetically engineered, glyphosate-tolerant crops. Both glyphosate and its main metabolite (breakdown product), aminomethylphosphonic acid (AMPA), are detected in water, soil, and food, […]
Posted in Agriculture, aminomethylphosphonic acid (AMPA), Cancer, Glyphosate, Herbicides, Kidney Damage, Metabolism, Oxidative Stress | No Comments »
Thursday, September 18th, 2025
(Beyond Pesticides, September 18, 2025) Published in Environmental Toxicology and Pharmacology, a study of earthworms (Eisenia fetida) evaluates the toxicity of environmentally relevant levels of three fluorinated pesticides (fluxapyroxad, fluopyram, and bixafen) through a 56-day soil exposure experiment. The dose- and time-dependent results reveal that effects on growth and reproduction occur at elevated concentrations, with weight loss and reduced offspring occurring from energy depletion and reproductive organ damage. Other implications escalate with concentration as well, including antioxidant system failure and DNA damage. As the authors summarize, âThese findings highlight the mechanisms of fluorine-containing pesticide toxicity in earthworms, emphasizing their potential to disrupt soil ecosystems.â Fluorine-containing pesticides are widely used in agriculture, yet the chronic effects on soil and soil organisms are not fully considered in regulatory review. Research comparing the similarities and differences in the impacts on nontarget organisms from fluorinated pesticides is lacking, with the current study beginning to address the urgent need to close this gap. âData indicate that among more than 100 newly developed pesticides, fluorine-containing pesticides constitute nearly half, making them a focal point in the development of the global pesticide industry,â the researchers state. As representatives of the fluorinated pesticides class, particularly succinate dehydrogenase inhibitors […]
Posted in Agriculture, Beneficials, Biodiversity, DNA Damage, Ecosystem Services, fluopyram, fluxapyroxad, Microbiome, Pesticide Regulation, Reproductive Health, soil health, Soil microbiome | No Comments »
Wednesday, September 10th, 2025
(Beyond Pesticides, September 10, 2025) Published earlier this year, a review of over 1,700 studies in Nature Communications finds pesticides affect a diverse range of nontarget organisms and contribute to global biodiversity loss. The authors* reveal ânegative responses of the growth, reproduction, behaviour and other physiological biomarkers within terrestrial and aquatic systemsâ for nontarget plants, animals, and microorganisms. âTo our knowledge, there has been no systematic and overarching synthesis of how different types of pesticides affect the diversity of multiple non-target eukaryotic and prokaryotic organisms across all trophic levels,â the researchers write. They continue, âFurthermore, current syntheses have not considered how the impacts of pesticides differ globally across climatic zones or for major mechanisms of exposure, such as those acting in aquatic or terrestrial environments.â In particular, pesticide regulatory risk assessments analyze a limited range of model species, including rats, zebrafish, clawed frogs, honeybees, and earthworms, among others. As such, they are unlikely to capture the variety of responses to pesticide exposure seen across the diversity of species and communities found in both managed and natural systems,â the authors state. *Authors include Beyond Pesticides 2023 National Forum speaker Dave Goulsonâsee the Daily News on his keynote address here. Research Results […]
Posted in Aquatic Organisms, Beneficials, Biodiversity, DNA Damage, Fungicides, Herbicides, Nervous System Effects, Pesticide Mixtures, synergistic effects, Wildlife/Endangered Sp. | No Comments »
Friday, September 5th, 2025
(Beyond Pesticides, September 5, 2025) A study in Journal of Agricultural and Food Chemistry finds permethrin, a commonly used synthetic pyrethroid insecticide, to be disruptive to the gut microbiome, altering microbiota and leading to increased formation of fat cells (adipogenesis) and metabolic disorders. With an aim to âcomprehensively elucidate the effects of permethrin on gut microbiota, lipogenesis, and the associated molecular mechanisms,â the study explores the adverse effects of permethrin exposure in adult mice through multiple experiments. âOur study provides the first in vivo [in a living organism] evidence suggesting a potentially causal relationship between permethrin exposure and the development of obesity, potentially mediated by specific gut microbiota-derived metabolites,â the researchers explain. They continue, âNotably, this work is the first to define a distinct microbiotaâmetaboliteâhost axis as a critical mediator of environmental toxicant-induced metabolic dysfunction.â Permethrin is widely used as an insecticide on crops, such as cotton, corn, and wheat, as well as on livestock, in indoor and outdoor areas, and for treating lice and scabies. Mosquito abatement programs often utilize permethrin, further adding to the various exposure routes of this neurotoxic chemical. (See additional uses and health effects of permethrin in Beyond Pesticidesâ Gateway on Pesticide Hazards and Safe […]
Posted in Agriculture, Diabetes, Gut Dysbiosis, Metabolites, Microbiome, Obesity, Permethrin, pyrethroids, Synthetic Pyrethroid | No Comments »
Thursday, August 14th, 2025
(Beyond Pesticides, August 14, 2025) A review in Clinical and Experimental Obstetrics & Gynecology links various classes of environmental pollutants including pesticides and per- and polyfluoroalkyl substances (PFAS), both of which Beyond Pesticides has extensively covered, to adverse effects on the female reproductive system and common mechanisms of toxicity. These chemicals âdisrupt the hypothalamic-pituitary-gonadal axis (HPG), impair ovarian function, and contribute to reproductive dysfunction through mechanisms such as oxidative stress, hormonal disruption, and epigenetic [gene expression or behavior] modifications,â the authors say. This leads to menstrual irregularities, infertility, and pregnancy complications, as well as increases in the risk of reproductive system disorders such as endometriosis, polycystic ovary syndrome (PCOS), and ovarian cancer, among others. âAdditionally, transgenerational effects mediated by epigenetic modifications, germ cell damage, and placental transfer may adversely affect offspring health, increasing the risk of reproductive dysfunction, neurodevelopmental disorders, metabolic diseases, and cancer,â the researchers explain. This study, integrating recent epidemiological and experimental findings, provides an overview of major chemical classes that threaten womenâs health and highlights the need for immediate action. As the authors point out, female reproductive health is important not only for those who choose to plan for a family but also for the overall well-being […]
Posted in Birth defects, Cancer, contamination, Developmental Disorders, DNA Damage, Endocrine Disruption, Epigenetic, Glyphosate, Infertility, Miscarriage, multi-generational effects, organochlorines, organophosphate, Oxidative Stress, PCOS, Reproductive Health, synergistic effects, Women's Health | No Comments »
Wednesday, July 30th, 2025
(Beyond Pesticides, July 30, 2025) The definition of per- and polyfluoroalkyl substances (PFAS), also known as âforever chemicalsâ due to their persistence, continues to be debated in regulatory agencies, with many scientists arguing that certain types of chemicals in this vast group are not accurately captured in risk assessments. A wide body of science on the adverse health and environmental effects of PFAS exists, as these synthetic chemicals have become ubiquitous in nature, wildlife, and humans, as demonstrated by biomonitoring studies. Recent research, documented in a literature review in Environmental Science & Technology and additional articles, highlights the importance of a universal, cohesive definition of PFAS that incorporates all fluorinated compounds, including the long carbon chain PFOA (perfluorooactanoic acid) and PFOS (perfluorooctanesulfonic acid) as well as the ultrashort-chain perfluoroalkyl acids (PFAAs). In order to protect health and the environment from the ever-increasing threat of both long and short chain PFASâ adverse effects, including cancer, endocrine-disrupting effects, and immune system damage, a comprehensive definition of the compounds causing harm is critical to adequate protection and regulatory decisions. The multitude of sources of PFAS and various exposure routes leads to widespread contamination of the environment and organisms. PFAS in agriculture represents a […]
Posted in Agriculture, Biodiversity, Biomonitoring, Cancer, contamination, Drinking Water, Endocrine Disruption, Immunotoxicity, PFAS, Water | No Comments »
Tuesday, July 22nd, 2025
(Beyond Pesticides, July 22, 2025) A study published in May by Nature Reviews Endocrinology warns that endocrine-disrupting chemicals (EDCs)âsubstances that lead to disruption of the endocrine system in an organismâare driving a rapid rise in female reproductive disorders. While EDCs encompass many different forms of chemicals, such as plastic additives, cigarette smoke, and paracetamol, pesticides are among the most common EDCs. The review pays special attention to pesticide classes such as per-and polyfluoroalkyl substances (PFAS) and organochlorines to evaluate how they derail ovarian development, puberty timing, and hormonal balance across the entire female lifespan. Many pesticides are fluorinated, and therefore classified as PFAS. Background Pesticides represent one of the largest sources of EDC exposure. Many persistent organic pollutants (POPs) are resistant to degradation and are capable of bioaccumulating in the food chain, which leads to these harmful chemicals being found in human adipose tissue. The study notes that these chemicals have also been detected in human blood, breast milk, follicular fluid, and other biological samples, explaining their prevalent presence in the human body. The review emphasizes that humans are exposed to a mixture of EDCs across their lifespan, yet current U.S. regulatory strategies do not fully account for combined lifetime […]
Posted in Endocrine Disruption, Infertility, PCOS, Reproductive Health, Uncategorized, Women's Health | No Comments »
Tuesday, July 15th, 2025
(Beyond Pesticides, July 15, 2025) A study published in Environmental Science and Technology finds that there are 47 current-use pesticidesâproducts with active ingredients that are currently registered with U.S. Environmental Protection Agency (EPA) âdetected in samples of indoor dust, drinking water, and urine from households in Indiana. This study builds on existing scientific literature documenting the public health threat of nonoccupational, indoor pesticide exposure. (See previous Daily News here, here, and here.) The study is a reminder that pesticides move into the indoor environment through the air, and on clothing, making exposure more widespread than the assumptions used in regulatory reviews. Background and Methodology âIn this study, we collected matched samples of indoor dust, drinking water, and urine from 81 households in Indiana, United States, and analyzed these samples for 82 CUPs [current use pesticides], including 48 insecticides, 25 herbicides, and 9 fungicides,â say the authors. They continue: âOf these, 47 CUPs were identified across samples of indoor dust, drinking water, and urine with median total CUP (âCUP) concentrations of 18 300 ng/g, 101 ng/L, and 2.93 ng/mL, respectively.â The herbicides (13) detected include 2,4-D (2,4-dichlorophenoxyacetic acid), Alachlor, Atrazine, CIAT (Desethyl-atrazine), Diuron, Metolachlor, Metolachlor OA (Oxanilic acid), OIAT (2-Hydroxy-4-isopropylamino-6-amino-s-triazine), OIET […]
Posted in 2,4-D, acetamiprid, Acetochlor, Alachlor, Atrazine, Clothianidin, Diazinon, dinotefuron, Diuron, Fipronil, Fungicides, Herbicides, Household Use, Imidacloprid, Indiana, Indoor Air Quality, Malathion, Metolachlor, Myclobutanil, neonicotinoids, organophosphate, Prometon, Propiconazole, pyrethroids, simazine, State/Local, tebuconazole, thiacloprid, Thiamethoxam, Uncategorized | No Comments »
Wednesday, July 9th, 2025
(Beyond Pesticides, July 9, 2025) Policymakers in Tanzania are calling for increased investments in organic agriculture for the 2025/26 fiscal year budget, demonstrating the increase in political will to advance new systems of farming and land management after decades of relying on Green Revolution-style, or chemical-intensive, policies. On June 20, various ministers representing the national government presented speeches to Parliament on the national governmentâs plan and budget recommendations, as well as highlighting the previous fiscal yearâs trends and use of funds. Â Political and popular support for organic agricultural systems has gained momentum across the globe. Worldwide, organic farming practices quadrupled from 2000 to 2018, with over 180 countries supporting a global transition to organic agriculture. Newly published global survey data by the Research Institute of Organic Agriculture (FiBL) and International Federation of Organic Agriculture Movements â Organics International (IFOAM) reveal global organic agriculture to be at an all-time high, with 71.5 million hectares of farmland in production as of 2020. (See Daily News here). Farmer and agricultural cooperatives around the world, from Brazil to Madagascar and Togo, leverage organic systems to develop competitive business models in regional, national, and international markets. (See Daily News here.) The European Union, with […]
Posted in Agriculture, Aldrin, Chemical Mixtures, Chlordane, Chlorpyrifos, DDT, Dieldrin, Endosulfan, Heptachlor, hexachlorobenzene (HCB), International, lambda-cyhalothrin, organochlorines, Tanzania, Uncategorized | No Comments »
Friday, June 27th, 2025
(Beyond Pesticides, June 27, 2025) An article in The New York Times (NYT), entitled “A Killer Within Easy Reach,” highlights the use of the weed killer paraquat, a widely used herbicide in the U.S. and many other parts of the world despite being banned in over 70 countries, as the cause of numerous suicides. The article references the tiny nation of Suriname, located on the northeastern coast of South America, as they have âone of the highest suicide rates in the world,â with the majority of those deaths involving paraquat. Globally, paraquat is prevalently used in self-harm incidents. The chemical, when absorbed into the body, among other deadly effects, causes pulmonary fibrosis, making lung tissue brittle and causing respiratory failure. While this pesticide is intended and generally used for weed control, it is also highly lethal to humans in small amounts and is often easily accessible in many households. As the NYT article states, âPesticides are among the leading means of suicide in agricultural areas of developing nations, implicated in more than 100,000 deaths annually.â Citing examples from around the world, the article states, âSri Lankaâs crop yields had surged after the introduction of modern fertilizers and pesticides in the […]
Posted in Cancer, Death, Herbicides, Kidney failure, Liver Damage, Oxidative Stress, Paraquat, Parkinson's, Reproductive Health, Respiratory Diseases, Suicide, Syngenta | 2 Comments »