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Daily News Blog

Archive for the 'Chemical Mixtures' Category


28
Apr

Review Identifies Regulatory Deficiencies in the Risk Assessments of Chemical Mixtures Including Pesticides

(Beyond Pesticides, April 28, 2026) In Chemical Research in Toxicology, researchers from the Universitat Rovira i Virgili in Catalonia, Spain highlight the threats to human and environmental health with “combined exposures to multiple chemical toxicants, including industrial chemicals, heavy metals, pesticides, endocrine-disrupting chemicals (EDCs), and per- and polyfluoroalkyl substances (PFAS).” As these compounds are encountered in mixtures in real-world settings, the resulting interaction can have additive or synergistic effects that risk assessments fail to adequately capture. As the authors point out: “This leads to a systematic underestimation of health risks, particularly for vulnerable populations. Despite robust evidence on mixture toxicity, major regulatory frameworks such as the U.S. Toxic Substances Control Act (TSCA) and the EU’s [European Union] REACH program continue to assess chemicals in isolation.” Importance and Background Environmental toxicants are ubiquitous throughout nature and within all organisms. In humans, these compounds can accumulate, referred to as ‘Body Burden’, which encompasses numerous chemicals such as pesticide mixtures. “Critically, organisms are rarely exposed to a single chemical in isolation,” the researchers note. “Rather, they continuously encounter complex mixtures of contaminants whose combined effects may differ substantially from those predicted by examining each substance individually.” As the authors explain, regulatory agencies underestimate […]

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24
Apr

Review Highlights Threats to Health and the Environment from Pesticide Contamination in the Atmosphere

(Beyond Pesticides, April 24, 2026) In a review of scientific literature documenting pesticide contamination in the atmosphere, international researchers find human and ecosystem exposure even in remote and distant areas. As published in the Journal of Hazardous Materials, the authors state: “Atmospheric transport of pesticides is a globally significant yet widely underestimated driver of human and ecological exposure, with contamination documented far beyond treated fields. This review provides a novel integrated synthesis, bridging emission pathways, atmospheric transformation processes, monitoring evidence, model limitations, and regulatory gaps to deliver a comprehensive understanding of the fate and impacts of pesticides in the atmosphere.” In analyzing the current knowledge on pesticide emissions, through both drift and volatilization (process where a solid or liquid converts into a gas or vapor), the researchers highlight “the widespread detection of both current-use and banned pesticides in environmental matrices far from their application,” along with the resulting implications for human health and environmental health. As the current risk assessment framework “fails to adequately address the perturbations caused by the atmospheric transport of pesticides,” the urgent need to transition away from chemical-intensive practices grows stronger. Background While this review highlights regulatory gaps in the European Union (EU), the cited scientific […]

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15
Apr

Banned and Current Use Pesticides, Some from Outdoor Use, in Indoor Dust Raises Alarm, According to Study

(Beyond Pesticides, April 15, 2026) Researchers in the Czech Republic tested indoor dust across 116 homes and found that 93 percent of homes across urban and rural areas contained residue of at least one current-use pesticide (CUP). The study also found in every household residues of hexachlorobenzene (HCB) and pentachlorobenzene (PeCB), the breakdown products or byproducts of certain banned organochlorine pesticides (OCP). These compounds, as well as DDT metabolites DDE and DDD, were detected in more than half of the homes tested. Results in this study and previous research confirm that pesticides used outdoors find their way indoors, resulting in an exposure pattern that is not calculated when pesticides are registered and allowed on the market. The findings are published in Indoor Environments. These findings characterize the legacy of toxic pesticide exposure resulting from the proliferation of pesticides in the United States and around the world without a complete assessment of the chemicals’ residual activity and multigenerational adverse impacts on health. Based on the decades of peer-reviewed scientific literature on pesticide exposure and effects from across the globe, public health and environmental advocates warn that there is a continuation of this pattern of long-term effects associated with new pesticides linked […]

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26
Mar

Pesticide User’s “Take-Home,” Other Nonoccupational Residues Raise Household Exposure Alarm

(Beyond Pesticides, March 26, 2026) A review of pesticide exposure from a family member working in agriculture (“take-home” residues) finds that pesticide levels in the home are elevated between 2.6- and 3.7-times. This and other nonoccupational exposure data from homes are drawn from the Agricultural Health Study (AHS), a National Cancer Institute (NCI) and National Institute of Environmental Health Sciences (NIEHS) prospective study of cancer and other health outcomes in a cohort of licensed pesticide applicators and their spouses from Iowa and North Carolina. Between 1993 and 1997, with follow-up between 1999 and 2021, AHS tracks occupational and nonoccupational exposure and subsequent health effects from pesticide exposure. The current study, published in Environmental Advances, reexamines a quantitative analysis on nontarget, “active-ingredient-specific” exposure to pesticides from multiple pathways—applying new criteria to AHS spousal exposure to the insecticide chlorpyrifos and the herbicide atrazine. The three pesticide exposure pathways include take-home, agricultural drift, and residential use. Building on a 2019 study, researchers consider data from additional studies published between 2019 and 2024, “providing support that all three pathways contribute to pesticide exposure.” More importantly, the updated estimates of nontarget exposure to chlorpyrifos and atrazine are overall strengthened by the incorporation of new data, highlighting the […]

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13
Mar

Study Shows Widely Used Weed Killer To Contain PFAS, Further Threatening Health and the Environment

(Beyond Pesticides, March 13, 2026) In a press release on March 10, 2026, Public Employees for Environmental Responsibility (PEER) cites independent test data on the herbicide indaziflam with detections of per- and poly-fluoroalkyl substances (PFAS), the “forever chemicals” known for significant toxicity at low level exposure and high persistence. The product, Rejuvra™, is produced by Envu (a former division of Bayer) and “is being sprayed and considered for use across millions of acres of Bureau of Land Management (BLM) and US Forest Service land.” Scientific literature connects indaziflam and PFAS with adverse effects to human, soil, and biodiversity health, raising serious concerns about their wide use in agriculture and general land management of lawns, parks, playing fields, ornamentals, fence lines, rights-of-way, rangeland, open space, and Christmas trees. Background As a pre-emergent weed killer used to kill annual grasses and unwanted broadleaf plants, the fluoroalkyltriazine herbicide is broadly labeled for use in residential areas, commercial ornamental and sod production, forestry, and mostly orchard crops. While indaziflam is considered a “selective” herbicide, it actually kills and prevents germination of a wide range of broad-leaved plants and grasses and comes close to being a soil sterilant.  Since the chemical is subject to drift […]

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18
Feb

Dietary Exposure of Poultry to Common Pesticide Mixtures Threatens Reproductive Health, Study Finds

(Beyond Pesticides, February 18, 2026) Research finds that widespread agricultural pesticide use increases chronic dietary exposure in poultry and leads to adverse reproductive effects, despite meeting legal residue limits. As published in Poultry Science by researchers in Poland, the study analyzes low-dose exposure of roosters (Gallus gallus domesticus) to the fungicide tebuconazole (TEB), the insecticide imidacloprid (IMI), and the weed killer glyphosate (GLP) individually and in mixtures, with all concentrations at or below the maximum residue limits (MRLs) established by the European Union (EU). “Sub-MRL pesticide exposure impaired male reproductive function, with the most pronounced effects observed following combined treatments,” the authors report. They continue: “[E]xposure resulted in reduced semen quality, decreased fertility and hatchability, and increased embryo mortality, particularly in groups receiving IMI alone or in combination. These functional impairments were accompanied by detectable pesticide residues in reproductive tissues and body fluids, as well as modulation [modification/alteration] of local and systemic immune parameters.” The results of the experiment highlight how combined pesticide exposure, resulting from common use of multiple pesticide active ingredients concurrently, produces “stronger and more persistent reproductive effects than individual compounds, indicating mixture-specific toxicity.” This study is particularly important, as it represents the chronic exposure to MRL-compliant […]

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21
Jan

USDA Monitoring Report Declares Pesticide Residues in Food Supply Safe, Despite Science to the Contrary

(Beyond Pesticides, January 21, 2026) The data in the annual U.S. Department of Agriculture (USDA) pesticide residue report, released earlier this month, continues to show a pattern of pesticide residues in the majority of food tested by the U.S. Department of Agriculture (USDA). Health advocates say low-level pesticide residues in the food supply within legal limits raise serious hazard concerns, while USDA, in its Pesticide Data Program–Annual Summary, Calendar Year 2024, points to controversial residue standards as a measure of safety. The USDA report finds that over 57 percent of tested commodities contain at least one pesticide and that less than one percent of detected residues violate the legal limit set as a tolerance by the U.S. Environmental Protection Agency (EPA). Residues allowed under tolerances establish allowable pesticide use patterns in agriculture that, beyond dietary risks, result in exposure to farmworkers, farmers, waterways, wildlife, and the broad ecosystem in which they are used. (See Eating with a Conscience for a list of pesticides allowed in food production by commodity.) With respect to the preponderance of evidence on adverse health and ecological effects of cumulative exposure to toxic agrichemicals, including pesticides, Beyond Pesticides has called for the transition to organic agriculture. […]

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19
Dec

Tis the Season for Family and Friends To Think About Going Organic for Safety Reasons—Christmas Trees in Focus

(Beyond Pesticides, December 19, 2025) While still the exception rather than the norm, a growing movement of Christmas tree farmers across the United States is demonstrating that organically managed systems can also be applied when choosing a tree during this holiday season. Health and environmental advocates across the country are calling for a transition away from toxic pesticide dependency during the holiday season. Beyond Pesticides maintains a webpage, Christmas Trees and Pesticides, and Center for Biological Diversity and Alliance of Nurses for Healthy Environments urged the U.S. Environmental Protection Agency and U.S. Department of Health and Human Services to conduct a “special review of pesticides used on Christmas trees.” The groups sent a letter on December 4, the day the National Christmas Tree was lit at the White House, specifically citing the need to review the pesticides chlorpyrifos, carbaryl, dimethoate, bifenthrin, chlorothalonil, glyphosate, hexazinone, imidacloprid, simazine, and 2,4-D, among others. Christmas is one of the most celebrated holidays in the United States, with Christmas trees grown on Christmas tree farms being brought into homes as part of the celebration. On average, Americans purchase 25 to 30 million Christmas trees annually, according to the National Christmas Tree Association; however, certified organic […]

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11
Nov

Toxic Chemical Exposure During Military Service Recognized as Threatening Veterans’ Health

(Beyond Pesticides, November 11, 2025) A study published in Cardiovascular Toxicology (July 2025) finds significant associations between Gulf War deployment-related toxic chemical exposure hazards and various adverse health outcomes, including heightened risk of atherosclerotic cardiovascular diseases (ASCVDs), such as “heart attack, coronary heart disease, stroke, transient ischemic attack, and peripheral vascular disease.” While there were no significant associations found directly between pesticide products and these adverse health effects, researchers attribute this to limited sample sizes and wide confidence intervals as part of the study methodology. Further research is necessary to build on this study, given the preponderance of scientific evidence linking pesticide exposure to heightened health risks to the cardiovascular system. On the issue of statistical significance, the authors state the following: “There may be difficulty [for survey respondents] remembering the[ir] military exposure history since the survey was completed nearly 25 years after the Gulf War.” While it is difficult to pinpoint pesticide exposure as a cause of illness among the toxic mixtures to which service members are exposed, there has been recognition by the Veterans Administration (VA) of diseases that are directly related to military service. Beyond Pesticides previously reported that the VA has established 20 burn pit and […]

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04
Nov

Synergistic Effects from Glyphosate and Urea Fertilizer Magnify Earthworm Poisoning

(Beyond Pesticides, November 4, 2025) A study of earthworms published in Environmental Science & Technology highlights how chemical mixtures can have both synergistic and species-specific effects, threatening the soil microbiome and overall soil health. In exposing two species, Eisenia fetida and Metaphire guillelmi, to the weed killer glyphosate alone and in combination with urea, a form of synthetic nitrogen fertilizer, the researchers find enhanced toxicity with co-exposure as well as varying health effects between the two species. These results emphasize the need to test a wide variety of nontarget organisms for impacts from environmental contaminants, since species, even within the same genus or family, can exhibit vastly different effects. Glyphosate, as one of the most widely used herbicides worldwide, is highly researched, with a multitude of studies linking the weed killer to effects on humans, wildlife, and soil ecosystems. Since simultaneous application of glyphosate and urea frequently occurs in agriculture, the effects of this mixture on earthworms are crucial for understanding the overall impacts on soil health. In exposing the two species to the individual compounds and as a mixture, the authors report increased glyphosate residues in earthworm gut contents, reduced body weight, aggravated intestinal tissue damage, sharply decreased digestive […]

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30
Oct

Hyperactive Behavior in Preschoolers Linked to Endocrine Disrupting Chemical Exposure

(Beyond Pesticides, October 29, 2025) A study published in Environment International evaluates residues of individual and mixtures of endocrine-disrupting chemicals (EDCs), including pesticides, and finds an association between exposure and hyperactive behavior in children. The researchers evaluated urine samples from over 800 preschoolers, identifying and statistically analyzing concentrations of 22 EDCs, and finding that nine of these chemicals are significantly associated with hyperactivity trajectories and EDC mixtures are positively associated with hyperactive behavior, noting the strongest association in girls.  “The current study indicates the adverse health effects of exposure to mixtures of EDCs among preschoolers, and suggests gender specificity in these effects,” the researchers state. They continue, “This highlights the importance of focusing on multi-pollutant exposure in early childhood.”  Study Importance  “Attention-deficit/hyperactivity disorder (ADHD) is a common neurodevelopmental disorder in children, which has become one of the main factors leading to the burden of disease in children and adolescents worldwide.” The authors continue: “Its core symptoms are high levels of inattention and/or hyperactivity/impulsivity during the preschool period. A meta-analysis showed that the overall prevalence of ADHD in children in China over the past 15 years was as high as 6.2%, and has been increasing over recent years.”  In comparison, according […]

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10
Sep

MAHA Strategy Report Backs Off Pesticides After Defining Serious Threat in Earlier Assessment

(Beyond Pesticides, September 10, 2025) After being criticized by the chemical industry and allied agribusiness and service industry groups on the Make America Healthy Again (MAHA) report in May, the strategy document, released yesterday, has tamped down efforts to reform government programs that regulate pesticides. There are no specific recommendations on improving the regulation of pesticides. Rather, the strategy appears to embrace business-as-usual and could even ramp up government efforts to tout the need for pesticides and claims that current regulatory reviews are effective and comprehensive. In a section of the strategy entitled “Increasing Public Awareness and Knowledge,” the document says: “EPA, partnering with food and agricultural stakeholders, will work to ensure that the public has awareness and confidence in EPA’s pesticide robust review procedures and how that relates to the limiting of risk for users and the general public and informs continual improvement.” This is at odds with the earlier MAHA assessment report which identified pesticides as substances of concern that, citing deficiencies in chemical reviews, “may be neglecting potential synergistic effects and cumulative burdens, thereby missing opportunities to translate cumulative risk assessment into the clinical environment in meaningful ways.” While the earlier report, Make Our Children Healthy Again: Assessment, […]

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31
Jul

Sublethal Effects of Weed Killer Glyphosate Associated with Colony Decline, According to Study

(Beyond Pesticides, July 31, 2025) A study published in Environmental Advances finds that hundreds of honeybee hives across central and northern Italy are contaminated with various pesticides and their metabolites, including glyphosate and fosetyl.  “There was no significant difference in glyphosate presence between dead/dying and live bees, suggesting chronic exposure rather than acute toxicity. However, higher pesticide concentrations in dead/dying bees indicate potential sublethal effects contributing to colony distress,” according to the authors. This peer-reviewed study builds on the mounting evidence outlined in the literature connecting pesticide residues to nontarget harm to pollinators and other insects and animals that are critical to biodiversity. Background and Methodology “The primary objectives of this study were to develop and validate a reliable, sensitive method for analyzing polar pesticides [highly soluble in water] in honeybees and to investigate polar pesticides residue levels in honeybees across northern and central Italy,” say the researchers of this study, who conduct research at the Experimental Zooprophylactic Institute of Lombardy and Emilia Romagna “Bruno Ubertini”, Experimental Zooprophylactic Institute of Umbria and Marche “Togo Rosati”, and Experimental Zooprophylactic Institute of Lazio and Tuscany “M. Aleandri.” 314 honeybee samples were gathered voluntarily from local beekeepers in six regions of northern and […]

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09
Jul

Tanzania at a Crossroads, Building an Organic Future after Decades of Toxic Pollution

(Beyond Pesticides, July 9, 2025) Policymakers in Tanzania are calling for increased investments in organic agriculture for the 2025/26 fiscal year budget, demonstrating the increase in political will to advance new systems of farming and land management after decades of relying on Green Revolution-style, or chemical-intensive, policies. On June 20, various ministers representing the national government presented speeches to Parliament on the national government’s plan and budget recommendations, as well as highlighting the previous fiscal year’s trends and use of funds.   Political and popular support for organic agricultural systems has gained momentum across the globe. Worldwide, organic farming practices quadrupled from 2000 to 2018, with over 180 countries supporting a global transition to organic agriculture. Newly published global survey data by the Research Institute of Organic Agriculture (FiBL) and International Federation of Organic Agriculture Movements – Organics International (IFOAM) reveal global organic agriculture to be at an all-time high, with 71.5 million hectares of farmland in production as of 2020. (See Daily News here). Farmer and agricultural cooperatives around the world, from Brazil to Madagascar and Togo, leverage organic systems to develop competitive business models in regional, national, and international markets. (See Daily News here.) The European Union, with […]

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04
Jul

Life, Liberty, and the Pursuit of Happiness: Protecting Health and the Environment This Independence Day

(Beyond Pesticides, July 3-4, 2025) On this Independence Day, Beyond Pesticides calls for holistic solutions that, as articulated in the Declaration of Independence, move the nation to ensure “certain unalienable Rights, that among these are Life, Liberty, and the pursuit of Happiness.” The founders of the United States were aware of the existential threat of corruption to democratic institutions. Alexander Hamilton, the first Secretary of the Treasury, warned in Federalist No. 68 of The Federalist Papers that the presidency could be overtaken by a despotic figure without adequate safeguards. James Madison, the fourth president of the United States, in Federalist No. 10 speaks to the danger that factions—defined as a group of people or entities “… who are united and actuated by some common impulse of passion, or of interest, adversed to the rights of other citizens, or to the permanent and aggregate interests of the community”—impose on the general public, if not checked by safeguards in the country’s political system. The foundational principles in the Declaration of Independence and the Constitution have been challenged under the current administration and in the U.S. Congress. Communities are facing a fourfold attack on these principles and the centuries-old promise of the nation: […]

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30
May

MAHA Commission Report Raises Health Concerns with Pesticides, Draws Industry Criticism—What’s Next?

(Beyond Pesticides, May 30, 2025) The Making America Healthy Again (MAHA) Commission report, Make Our Children Healthy Again: Assessment, published on May 23, drew criticism from the pesticide industry and agribusiness allies for pointing to independent science that identifies a range of pesticide-induced health hazards.* The Commission, chaired by Robert F. Kennedy, Jr., Secretary of the Department of Health and Human Services (HHS), is composed of the heads of numerous agencies of the federal government and the White House, from the U.S. Environmental Protection Agency (EPA), the U.S. Department of Agriculture (USDA), and the Office of Management and Budget (OMB), to the Assistant to the President and Deputy Chief of Staff for Policy Stephen Miller. The MAHA Commission was established by Executive Order 14212 on February 13, 2025. Despite extensive citations to the science on pesticide hazards, the report includes a section on “Crop Protection Tools,” in which there is a repetition of chemical industry talking points that pesticide residues in food comply with existing tolerances, thus implying that pesticides in food are safe. (See USDA Pesticide Data Program Continues to Mislead the Public on Pesticide Residue Exposure.) However, overall the report’s introduction sets a tone that seeks to catalogue […]

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22
May

Golf Courses Linked to Parkinson’s Disease and Pesticide Use

(Beyond Pesticides, May 22, 2025) A medical study published in the Journal of the American Medical Association (JAMA) finds that “living within 1 mile of a golf course was associated with 126% increased odds of developing PD [Parkinson’s Disease] compared with individuals living more than 6 miles away from a golf course.” While organic land management offers a simple solution, current pesticide restrictions do not address chronic neurological diseases such as Parkinson’s Disease, which are linked to pesticide exposure. It has become increasingly clear that viable and cost-effective land management practices, including for golf course management, are critical to the protection of community health. Yet, the federal regulatory agencies, including the U.S. Environmental Protection Agency (EPA) and U.S. Food and Drug Administration (FDA), do not conduct an alternative practices assessment as part of their review process to determine whether the risks are “reasonable” (statutory language) or the risk assessments accept an unnecessary hazard. The complexity of pesticide exposure, which includes mixtures of multiple chemicals and undisclosed hazardous “inert” ingredients, raises broad questions about the threats to public health as well as biodiversity. See a recent Action of the Week, FDA Must Establish Tolerances for Pesticides Used in Mixtures, to see […]

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07
May

Farmers Face Elevated Cancer Risks Tied to Chemical Soup of Pesticide Exposure

(Beyond Pesticides, May 7, 2025) Researchers at the University of Caxias do Sul (Brazil) identify 29 peer-reviewed scientific studies with statistically significant findings that tie pesticide use to cancer diagnoses. The literature review is published in SaĂşde Debate. This collection of clinical trials, as well as epidemiologic, case-control, and experimental studies—from the United States, Brazil, India, France, Egypt, Columbia, Ecuador, Mexico, Italy, and Spain—add to the hundreds of peer-reviewed independent analyses connecting synthetic chemical dependency in food production and land management with mounting public health concerns. Advocates continue to call for holistic solutions that move away from toxic inputs that disproportionately harm the communities responsible for the food on dinner tables, and instead cultivate microbial diversity in soil, rather than prophylactically spray for the sake of pest control. Beyond Pesticides values the importance of scientific integrity and open access to data to inform decision makers on how to adopt healthier practices for their communities. Reliable information for good governance is critical, which is a driving factor in the ongoing compilation of thousands of peer-reviewed literature compiled and curated in the Pesticide-Induced Disease Database and Gateway on Pesticide Hazards and Safe Pest Management. Background and Methodology The main objective of this […]

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18
Apr

Widely Used Fungicide Mixed with Natural Mycotoxins Increases Toxicity of Treated Food Crops

(Beyond Pesticides, April 18, 2025) A recent study published in Foods assesses the ability of the fungicide azoxystrobin (AZX) and naturally occurring toxins produced by certain fungi, known as mycotoxins, to display effects of cytotoxicity (cell damage). These effects were evaluated using three common mycotoxins found in food, including ochratoxin A (OTA), deoxynivalenol (DON), and T-2 toxin as mixtures with AZX within human hepatocarcinoma (HepG2) cell cultures. In analyzing combinations of these compounds at sublethal concentrations, the authors find modified toxicological behavior and synergistic effects that highlight the complexities of chemical mixtures, and potential threats to liver health through dietary exposure to both toxicants and toxins, that are not adequately regulated for their interactions. While fungicides, like azoxystrobin, are intended to prevent or control fungal diseases, resistance to these pesticides can increase the presence of fungi, and subsequent mycotoxins, on crops. This scenario allows for co-exposure of fungicides and mycotoxins within food products that present a risk to consumers. These chemicals can threaten human health individually, as the researchers confirm in their study, but present a greater threat in combination. The mixture of AZX with all three mycotoxins exhibits the highest toxicity, with synergistic effects at all tested concentration levels. […]

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28
Mar

Sampling Finds Pesticides Throughout Environment with Toxic Mixtures from Agricultural Use

(Beyond Pesticides, March 28, 2025) The Rhine Valley in southwestern Germany is renowned for the agricultural bounty it has provided for centuries. Today, the area is home to dense wine, vegetable, fruit, and cereal cultivation. However, a study shows that current regulation of pesticides, even in the relatively progressive European Union, is inadequate to protect humans and all the other organisms that produce the environment necessary for human life and civilization.  The study goal was to determine how far—and which—pesticides traveled beyond the croplands of vegetables, fruit orchards, and cereals, as well forested lands, into nontarget areas that should serve as refugia for plants, animals, and invertebrates not considered pests. Based at the Landau Institute for Environmental Sciences at the University of Kaiserslautern-Landau, the researchers used innovative methods to measure the types, concentrations, and distribution of pesticides. They took samples from three landscape categories—vegetation, topsoil, and surface water—at 78 sites distributed along six transects, each reaching from the valley floor to the tops of the mountains on either side. Samples were taken from grasses, shrub leaves, and topsoils along each transect, together with water samples from rivers, small streams, ponds, and puddles. They tested for 93 current-use pesticides (CUPs). There […]

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13
Mar

Study of Pesticide Mixtures and Intestinal Barrier Dysfunction Further Highlights Regulatory Deficiencies

(Beyond Pesticides, March 13, 2025) Study results published in Pesticide Biochemistry and Physiology “suggest that combined [pesticide] exposure may further amplify the toxicity and compromise the intestinal barrier.” The researchers studied the toxic effects of the insecticides abamectin and spirodiclofen, as well as the fungicide fluazinam, individually and in combination. In exposing mice and Caco-2 cells to these pesticides, the results show the disruption of intestinal functions and highlight the need to assess potential synergistic effects of pesticide mixtures as a part of the regulatory review process.  Effects on the intestinal barriers of mice represent a threat to “the first line of defense against the external environment,” the researchers say. The intestinal mucosal epithelial structure plays an important role in preventing harmful substances from entering the intestines and causing damage to cells.  [Caco-2 cells represent a human cell line, derived from a colon cancer patient’s tissue, and mimic the small intestine. These cells are vital in research as a model of the intestinal epithelial barrier.]  “Currently, most studies investigating the effects of pesticide residues on the barrier function of Caco-2 cells concentrate on the exposure to a single residue, while the potential toxic effects arising from the concurrent presence of multiple pesticide […]

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04
Mar

Children’s Health Threatened as Rates of Pediatric Cancers are Linked to Agricultural Pesticide Mixtures

(Beyond Pesticides, March 4, 2025) A study in GeoHealth of pediatric cancers in Nebraska links exposure to agricultural mixtures with the occurrence of these diseases. The authors find statistically significant positive associations between pesticide usage rates and children with cancer, specifically brain and central nervous system (CNS) cancers and leukemia. “Our study is the first to estimate the effect of an agrichemical mixture on the pediatric cancer rate in Nebraska,” the study authors share. “One significant advantage of our study is that we identified the pesticide consistently applied over 22 years in Nebraska counties and then estimated the overall mixture effect of these pesticides on pediatric cancer.” The elevated effect of pesticide mixtures, a reality that is not evaluated in the U.S. Environmental Protection Agency’s (EPA) pesticide registration program, was reported in Oecologia (2008), documenting harm to amphibian populations even if the concentration of the individual chemicals is within limits considered acceptable. (See additional coverage here.) There is a wide body of science highlighting the disproportionate risk of adverse health effects in children with pesticide exposure. Their small size and developing organ systems, propensity to crawl and play near the ground, tendency for frequent hand-to-mouth motion, and greater intake of […]

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15
Jan

Lit Review Shows Depth of Research Linking Pesticide-Induced Effects on Immune System, Leading to Disease Outcomes

(Beyond Pesticides, January 15, 2025) There is robust scientific literature that unpacks the adverse human health effects of pesticide exposure, however immunological impacts do not receive adequate attention in regulatory review processes, according to an in-depth literature review. In a piece published in Frontiers in Immunology (2024) critiquing recent peer-reviewed scientific studies, as well as unpublished research produced by the Institute of Biology and Experimental Medicine in partnership with the National Scientific and Technical Research Council in Argentina, researchers assess immune system effects of pesticide exposure, which creates the conditions for deadly health conditions including various forms of cancer. The focus of this study, according to the authors, is “to critically review fundamental aspects of toxicological studies conducted on PPPs [Plant Protection Products] to provide a clearer understanding of the risks associated with exposure to these compounds on human health.” PPPs are pesticide products that contain more than one active ingredient, and can include synergistic ingredients that supercharge them alongside inert ingredients that pesticide companies are not legally required to disclose under the Federal Insecticide, Fungicide, and Rodenticide Act (FIFRA), but are often manipulated biologically and chemically active. Most studies analyze the toxicological impacts of active ingredients in isolation rather […]

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