03
May
(Beyond Pesticides, May 3, 2024) Parkinson’s disease (PD) is the second most common neurodegenerative disease in the world after Alzheimer’s. Genetic factors account for only a fraction of PD cases, and for decades scientists have been aware of associations between pesticide exposures and PD. Yet, not everyone exposed to pesticides gets PD. Consequently, neither the genetic nor the environmental hypothesis is fully satisfactory; both may be involved. Thus, there has been great interest in identifying gene variants that affect the risks of PD associated with pesticide exposure. Now a team of University of California at Los Angeles researchers led by neurologist Brent Fogel, MD, PhD has traced a connection between certain gene variants and the occurrence and severity of PD in a cohort of central California PD patients who have had long-term exposure to pesticides. The genes are related to autophagy, the process by which cells organize, degrade, recycle or eject molecules to maintain healthy chemical balance. Autophagy is an essential process throughout the body, including regulation of mitochondria, which are also vital for healthy cellular function. The study supports other research suggesting that autophagy is disturbed in neurodegenerative diseases. As Beyond Pesticides discussed in its April 19 Daily News, PD […]
Posted in arsenic, cacodylic acid, California, Carbamates, Farmworkers, Lewy Body Disease (LBD), Nervous System Effects, organoarsenic, organophosphate, Parkinson's, Uncategorized | No Comments »
17
Jun
(Beyond Pesticides, June 17, 2021) Lead arsenate pesticides continue to contaminate Central Washington residential areas that were once tree fruit orchards. Although these toxic legacy pesticides have not been in use for almost 70 years, the Washington State Department of Ecology report finds lead and arsenic soil concentrations above the Washington State cleanup levels. It is well-known that traces of legacy (past-use) pesticides, like organochlorines, remain in the environment for decades—possibly centuries, post-final application. However, these chemicals have profound adverse impacts on human health, with links to cancer, reproductive and endocrine (hormone) disruption, and birth/developmental abnormalities. Current-use pesticides also contaminate the ecosystem via drift, runoff, and leaching. Therefore the impact of both current and past use of pesticides on human, animal, and environmental health, especially in combination, is critical to any safety analysis. The researchers note, “Historical application of lead arsenate (LA) pesticides on tree fruit orchards has resulted in the accumulation of lead and arsenic in shallow soil at concentrations above Washington State cleanup levels. These are levels that may be harmful to human health when properties are used for activities other than agricultural or industrial land uses. This report outlines a recommended approach for managing and mitigating LA pesticide soil contamination, […]
Posted in Agriculture, arsenic, contamination, lead arsenate, Washington | No Comments »
12
Jul
(Beyond Pesticides, July 12, 2013) New research concludes that exposure to a combination of both arsenic and estrogen, at levels U.S. Environmental Protection Agency (EPA) considers “safe” for humans, can cause cancer at elevated levels in prostate cells. Texas Tech University researchers revealed that humans exposed to a combination of both toxicants were almost twice as likely to develop cancerous cells in their prostate. The study is published in the peer-reviewed journal The Prostate. While it is established that both arsenic and estrogen can cause cancer, the research raises concerns about the dangers of chemicals in combination, and the efficacy of regulations that are established by testing one chemical at a time. Kamaleshwar Singh, PhD., is an assistant professor at the Institute of Environmental and Human Health at Texas Tech. “The majority of cancers are caused by environmental influences,” Dr. Singh remarked to Texas Tech Today, “Only about 5 to 10 percent of cancers are due to genetic predisposition. Science has looked at these chemicals, such as arsenic, and tested them in a lab to find the amounts that may cause cancer. But that’s just a single chemical in a single test. In the real world, we are getting exposed […]
Posted in arsenic, Cancer, Endocrine Disruption, Pesticide Regulation, Prostate Cancer | No Comments »
20
Sep
(Beyond Pesticides, September 20, 2012) Raising questions about the adequacy of pesticide regulation, historically and ongoing, Consumer Reports published a new study yesterday that finds “worrisome” levels of inorganic arsenic in rice products. Arsenic is a known human carcinogen. This new report follows its earlier one that finds high levels of arsenic in apple and grape juice. The report finds elevated arsenic levels across organic and conventional products, raising serious questions about widespread environmental and soil contamination from past and continuing arsenical pesticide use. Although organic arsenic occurs naturally in the environment, it is synthetic inorganic arsenic that poses the biggest health hazards to humans and animals. So, humans are exposed to two kinds of the carcinogen in air, water, soil, and food sources. But unlike organic arsenic, which is found naturally in the environment, inorganic arsenic is present in our food as a result of pesticide application and animal feed. Arsenic is added to chicken feed as a supplement to control intestinal parasites and promote growth. It is consequently transferred into the meat of the animals and turns up in chicken manure. Arsenic is also widely used in the treatment of utility poles and in the arsenical herbicide MSMA […]
Posted in arsenic, Cancer, Chemicals, Pesticide Regulation | No Comments »
