(Beyond Pesticides, October 10, 2024) On September 16, 2024, the U.S. Environmental Protection Agency (EPA) announced an order allowing Kaizen Technologies LLC to sell off its chlorpyrifos-based insecticide product—Bifenchlor, a known neurotoxicant. This reverses an existing stocks agreement that Kaizen voluntarily negotiated with EPA in August 2022 when the company withdrew Bifenchlor from use. The agency attributes this new order to a November 2023 Eighth Circuit Court of Appeals decision, which vacated EPA’s prior 2021 chlorpyrifos ban on food crops (see here). EPA’s practice of permitting the sale and use of existing stocks of canceled pesticides has been a longstanding concern for public health and environmental advocates, as it enables the continued use of petrochemical pesticides that the agency has found to be dangerous. Chlorpyrifos, an organophosphate with adverse health effects on children (see here and here), is now the latest example.  In reporting on the almost unprecedented decision on August 7, 2024, to use its emergency authority to ban Dacthal/DCPA, Beyond Pesticides argues that the “Dacthal Standard” is a positive precedent, a step forward in modern regulatory history; however, EPA’s continued approval of chlorpyrifos’s existing stock, complicated by the 2023 court decision, may suggest otherwise.   As demonstrated historically with […]

(Beyond Pesticides, June 11, 2024) Published in Science of The Total Environment in May, a comprehensive literature review of population-based studies finds strong linkages between direct and acute pesticide exposure and elevated risk of breast cancer (BC). A majority of the studies analyzed in this review were based on population groups in the United States, but also extends to Australia and three European countries (Greece, France, and Italy). Included in these studies are women who worked in chemical-intensive agricultural settings, directly sprayed pesticides in their at-home gardens, and/or handled pesticide-contaminated clothing. The findings in this literature review underscore organic advocates’ concerns of relying on pesticide substitution models that inevitably impact the health of land stewards, farmers, farmworkers, and the broader public rather than transforming food systems to an organic model that bans the use of toxic petrochemical-based pesticides. The goal of this review was to synthesize existing literature on pesticide exposure and breast cancer to determine the specific pathways and underlying mechanisms that contribute to female participants’ heightened risk. This literature review was published online by researchers at the University of Arizona’s R. Ken Coit College of Pharmacy and Coit Center for Longevity and Neurotherapeutics and the Laboratory of Tumor […]

(Beyond Pesticides, October 4, 2023) A study published in Food and Chemical Toxicology finds acute exposure to chlordane, an organochlorine insecticide, results in decreased lipid (fat) levels, altered anti-oxidant capacity, and increased testosterone levels (pro-androgenic) in male mice, while increasing liver enzyme activation and reducing regulation of both liver identity and function in females. These findings indicate that chlordane induces toxicant-associated steatosis (fat retention) liver disease (TASLD) with underlying, sex-specific, endocrine, and metabolic effects. It is well-known that traces of legacy (past-use) pesticides, like organochlorine pesticides (OCPs), remain in the environment for decades—possibly centuries, post-final application, as OCPs have greater chemical stability and gradual attenuation. However, these chemicals have profound adverse impacts on human health, especially on the endocrine system. Obesity, insulin resistance, type 2 diabetes, and elevated liver enzymes resulting from endocrine disruption contribute to liver diseases and can lead to liver cirrhosis. Although some, but not all, manufacturing and use of specific OCPs have declined in the U.S., OCPs remain a global issue, as much of the developing world still report usage. Considering the lack of studies on OCP-induced endocrine disruption, TASLD, and other liver diseases, research like this highlights the need to understand the underlying mechanisms contributing to […]

(Beyond Pesticides, May 12, 2023) With the growth of chemical-intensive land management over the last century, the world has been held captive by pesticide companies. For part of that time, it could be said the modern society has suffered from Stockholm Syndrome, a theory about abusive relationships in which one party exerts power over the other using threats, fear, and lies and the victim comes to depend on the perpetrator emotionally. During the so-called “Green Revolution” (circa 1945-1985), the world came to depend on vast amounts of fertilizers and herbicides, insecticides, and fungicides. Many people believed that food, clothing, and shelter made from naturally-occurring materials such as fruit, flax and wood could not be provided to the world without pesticides. It seemed that science and commerce could indefinitely raise the standard of living around the world, perhaps leading to world peace. This is not what happened. Soon observers noticed the harmful effects of many pesticides, including their persistence in the environment, their tendency to accumulate in the bodies of humans and wildlife, and their influence on the risk of contracting many diseases, from cancer to asthma—not to mention the Darwinian inevitability of pest resistance. By the turn of the 20th […]

(Beyond Pesticides, December 6, 2022) Persistent organic pollutants (POPs)—including banned pesticides—present a health risk to humpback whales (Megaptera novaeangliae), according to a study published in Environmental Pollution. Regarding female humpback whales, levels of POPs in blubber are higher in juveniles and subadults than in adults, primarily from the transference of contaminants from the mother to her calf.  Organochlorine compounds (OCs), such as organochlorine pesticides (OCPs) and polychlorinated biphenyls (PCBs), are well-known persistent organic pollutants. The international Stockholm Convention treaty (signed by 152 countries, but not the U.S.) banned these primary pollutants of concern (UNEP, 2009) in 2001 (taking effect in 2004) because of their persistence, toxicity, and adverse effects on environmental and biological health. These pollutants have a global distribution, with evaporation and precipitation facilitating long-range atmospheric transport, deposition, and bioaccumulation of hazardous chemicals in the environment. However, these chemicals can remain in the environment for decades and interact with various current-use pesticides, including organophosphates, neonicotinoids, and pyrethroids. Although various studies demonstrate the volatile, toxic nature of POPs, much less research evaluates the impact POPs have on maternal offloading or transfer of contaminates to offspring and respective health consequences. The globe is currently going through the Holocene Extinction, Earth’s 6th mass extinction, with one […]

(Beyond Pesticides, November 7, 2022) The Maine Congressional delegation — Senators Collins (R) and Angus King (I), and Representatives Chellie Pingree (D) and Jared Golden (D), along with New Hampshire Senator Jeanne Shaheen (D) — have  introduced a bipartisan bill — the Relief for Farmers Hit with PFAS Act — to help farmers who have been adversely affected by the scourge of PFAS (perfluoroalkyl and polyfluoroalkyl substances) chemicals. The bills are the identical S. 5070 and H.R. 9186, both titled “Relief for Farmers Hit with PFAS Act.” Tell your U.S. Senators and Representative to cosponsor the Relief for Farmers Hit with PFAS Act. If they are already cosponsors, thank them. Tell EPA to stop the spread of legacy chemicals. PFAS chemicals, also known as “forever chemicals,” are legacy contaminants or those whose historical use, including many decades ago in some instances, has led to their toxic persistence in the environment and in organisms. PFAS chemicals are not the only legacy contaminants. Others include wood preservatives, DDT, dioxins, and the termiticide chlordane. Unfortunately, some of these continue to be added to the environment, sometimes inadvertently, but also intentionally, particularly through pesticide use. As indicated by the title of these bills, farmers […]

(Beyond Pesticides, October 18, 2022) Washington, D.C. Attorney General (AG) Karl Racine is suing chemical manufacturer Velsicol to recover damages caused by the company’s production and promotion of the insecticide chlordane despite full knowledge of the extreme hazards posed by the pesticide. Over 30 years after it was banned, chlordane is still contaminating homes, schools, yards, private wells and waterways throughout the United States, including DC’s Anacostia and Potomac rivers. While the District’s focus on restitution and remediation for this highly hazardous, long-lived insecticide is laudable, many advocates say the city is not doing enough to stop pesticide contamination currently entering the city’s waterways. Despite passage of a strong pesticide bill in 2016 limiting toxic pesticide use on schools, child occupied facilities, and within 75ft of a waterbody, D.C. Department of Energy and Environment (DDOE) director Tommy Wells has failed to update regulations and enforce the law. Chlordane is an organochlorine insecticide, of the same class as DDT, and was likewise discussed extensively in Rachel Carson’s Silent Spring. Like other organochlorines, it is bioaccumulative, increasing contamination levels as it works its way up the food chain, and highly persistent, remaining in the environment for decades and perhaps even centuries, with breakdown […]

(Beyond Pesticides, December 1, 2021) Women exposed to metabolites of the banned insecticide chlordane are over three times more likely to develop endometriosis, finds research published in the journal Environment International. The study is the latest to find links between persistent organic pollutants (POPs), still lingering in our environment and in our bodies, and chronic disease. According to an economic analysis conducted in 2016, exposure to endocrine (hormone) disrupting chemicals, often implicated in considerable damage to the body’s reproductive system, results in billions of dollars of health care costs from female reproductive disorders. Researchers set out to integrate two methodologies into their evaluation, combining analysis of POP biomarkers in blood with an analysis of biomarkers in that body that correspond with cell functioning, inflammation, and stress. A total of 87 women were enrolled in the study, half of whom had deep endometriosis, a quarter of whom also had the disease and sought surgical intervention, and a remaining quarter without reproductive concerns acted as a control. Twenty polychlorinated biphenyls (PCBs) and 30 organochlorine pesticide compounds were analyzed, as were various biomarkers and inflammatory cytokines. The analysis revealed two compounds to be positively associated with endometriosis – trans-nonachlor, a breakdown product of […]

(Beyond Pesticides, May 14, 2020) Four banned organochlorine pesticides (OCP) are present in over 60% of a cohort of reproductive-age, black women in Detroit, according to a study published in Environmental Research by Boston University School of Public Health (BUSPH). OCPs are lipophilic (fat combining/dissolving), environmentally steadfast chemicals linked to harmful health effects. This study stresses the importance of monitoring pesticide accumulation, particularly regarding environmentally persistent chemicals and their metabolization via indirect exposure routes. Lead author Olivia Orta, Ph.D., a postdoctoral research associate in the Department of Epidemiology at BUSPH, highlights the significance of water monitoring—especially in light of historically disproportionately high hazards for people of color (e.g., Flint, Michigan)—and testing sources prone to OCP contamination. She remarks, “The sources that we identified as potential OCP correlates should be tested for pesticide contamination,[…] especially drinking water.” Environmental contaminants, like organochlorine pesticides (OCP), can persist in the environment decades after use stops, as OCPs have greater chemical stability and gradual attenuation. Minority populations are at higher exposure risk of environmental contaminants (i.e., pesticide) exposure that can catalyze adverse health and birth effects, especially in metropolitan areas. Although black women endure higher body burdens than other U.S. populations, there remains a lack of research surrounding the association. Boston University researchers enrolled […]

(Beyond Pesticides, September 14, 2016) According to a recent study by the U.S. Geological Survey (USGS), high concentrations of dioxins and furans have been detected in tree swallow eggs collected near several sites around the Great Lakes. Other chemicals detected include polychlorinated biphenyls (PCBs) and polybrominated diphenyl ethers (PBDEs), which were at background levels. The study is part of efforts to clean up a toxic chemical legacy around the Great Lakes, and the researchers believe their results are critical to regulators to assess “bird or animal deformity or reproductive problems” The study, “Concentrations and spatial patterns of organic contaminants in tree swallow (Tachycineta bicolor) eggs at United States and binational Great Lakes Areas of Concern, 2010—2015,” used tree swallows to quantify current exposure to organic contaminants across all five Great Lakes including 59 sites within 27  Areas of Concern (AOCs)  and 10 nearby  locations. The Great Lakes Areas of Concern refers to a U.S.-Canada  Great Lakes Water Quality Agreement  (Annex 1 of the 2012 Protocol) that  defines AOCs as “geographic areas designated by the Parties where significant  impairment of beneficial uses  has occurred as a result of human activities at the local level.” An AOC is a location that has […]

(Beyond Pesticides, March 21, 2014) Banned pesticides and flame retardants may be the cause of higher autistic behaviors for children who were exposed in utero, according to new research published last week in the journal Environmental Health Perspectives. Previous research has demonstrated that organochlorine chemicals are linked to learning problems, such as attention-deficit hyperactivity disorder (ADHD), especially in boys. This research is one of the first studies to evaluate their contribution to autistic behaviors. According to the study, Gestational Exposure to Endocrine-Disrupting Chemicals and Reciprocal Social, Repetitive, and Stereotypic Behaviors in 4- and 5-Year Old Children, children who were exposed to higher levels of brominated flame retardant PBDE-28 and trans-nonachlor, a component of the banned pesticide chlordane, scored higher in terms of autistic behavioral patterns as ranked by their mothers. In the study, researchers conducted a case-cohort study recruiting 175 pregnant women from seven prenatal clinics within the greater Cincinnati, Ohio region who provided urine and blood samples during pregnancy to measure the concentration of endocrine disrupting chemicals. On average, pregnant women had 44 suspected hormone disrupting chemicals. Five years later, when children had turned four or five, mothers were asked to rank their children’s behavior based on a series […]

(Beyond Pesticides, July 9, 2012) Health officials in Connecticut are telling residents who drink from private wells to test their water for the banned pesticides chlordane and dieldrin, after a study from the town of Stamford, CT found at least one of the toxic chemicals in 195 out of 628 wells tested. Over half of the wells that tested positive for one of the pesticides were found to contain concentrations at levels above what the U.S Environmental Protection Agency (EPA) considers acceptable. Both of these chemicals, discussed at length in Rachael Carson’s seminal book Silent Spring, were widely used throughout the country before their ban in the late 1980s. Since then, these chemicals have revealed themselves to be pervasive in our environment. In 2007, Beyond Pesticides wrote on the discovery of chlordane on the grounds of a New Jersey middle school at levels above EPA limits. In 2009, the U.S Housing and Urban Development (HUD) and EPA conducted a survey that found chlordane in 64% of U.S households sampled. In 2010, we reported on the occurrence of these two historic-use chemicals in what are considered “pristine” National Parks. Unfortunately, if the water contamination residents are finding turns out to be […]

(Beyond Pesticides, November 15, 2011) Research published in the online edition of Environmental Health Perspectives finds that exposure to certain pesticides elevates the risk of non-Hodgkin’s Lymphoma (NHL). The study, “A Prospective Study of Organochlorines in Adipose Tissue and Risk of non-Hodgkin’s Lymphoma,” finds a positive correlation between levels of the organochlorine pesticides DDT, cis-nonachlor, chlordane, and their breakdown products in human fat tissue and the often deadly form of cancer. The researchers from the Danish Cancer Society’s Institute of Cancer Epidemiology conducted a case-cohort study using a prospective Danish cohort of 57,053 persons enrolled between 1993 and 1997. Within the cohort they identified 256 persons diagnosed with NHL in the population-based nationwide Danish Cancer Registry and randomly selected 256 sub-cohort persons. The research team measured concentrations of eight pesticides and ten polychlorinated biphenyl congeners (PCBs) in fat tissue collected upon enrollment. The results indicate a higher risk of NHL in association with higher fat tissue levels of DDT, cis-nonachlor and oxychlordane, but shows no association with PCBs. Because the tissue samples were taken up to 15 years prior to the cancer diagnosis, the research suggests that exposure to these organochlorines increases the risk of NHL later in life and […]

(Beyond Pesticides, October 14, 2011) Researchers at Uppsala University in Sweden have found that environmental toxicants such as dioxins, PCBs, and pesticides can pose a risk for cardiovascular disease. The results of the study, entitled “Circulating Levels of Persistent Organic Pollutants (POPs) and Carotid Atherosclerosis in the Elderly,” show a link between exposure to persistent organic pollutants (POPs), including several organochlorine pesticides, and the development of atherosclerosis, which can lead to heart disease. The study will be published in the journal Environmental Health Perspectives, and a version of it is available online ahead of print. Cardiovascular diseases, including heart attacks and strokes, are the most common cause of death in industrialized countries, and the most important underlying cause of these diseases is atherosclerosis. Unbalanced blood fats, diabetes, smoking, and high blood pressure are traditionally recognized risk factors for atherosclerosis. Previous studies have also reported possible links between cardiovascular disease and high levels of persistent (long-lived and hard-to-degrade) organic environmental toxicants, such as dioxins, polychlorinated biphenyls (PCBs), and pesticides. These compounds are fat-soluble and can therefore accumulate in vessel walls. However, no earlier studies have investigated possible links between exposure to these compounds and atherosclerosis. Of the POPs that were screened […]

(Beyond Pesticides, July 11, 2011) The findings of a research team suggest that the concentrations of the banned but still persistent insecticide chlordane and the widely used insecticide permethrin in cord blood may be associated with inflammatory cytokines (signaling molecules of the nervous and immune system important to intercellular communication) in the fetus. The results from the research team were significant because few studies on the developmental effects of chlordane and permethrin in humans have been performed, and they were the first to demonstrate an association between in utero exposures with changes in the immune systems of newborns. The data and findings are found in this month’s Research Brief by the National Institute of Environmental Health Sciences (NIEHS) Superfund Research Program, which highlights the widespread aggregate pesticide exposure that individuals in the U.S. experience, focusing on a recent study on the developmental effects of chlordane and permethrin mixtures. The study looks at the relationship between cord serum concentrations of chlordane and permethrin pesticides, gestational age, size at birth and the presence of inflammatory cytokines, which are endogenous proteins secreted as signaling compounds to coordinate immune system functions. The study, entitled “Fetal Exposure to Chlordane and Permethrin Mixtures in Relation to […]

(Beyond Pesticides, June 25, 2010) Two new studies published in the journal Environmental Science and Technology confirm that the majority of toxic contamination threatening national parks originates from agricultural pesticides and industrial operations. In one study an international group of scientists conducted research from 2003-2005 and detected elevated concentrations of various dangerous pesticides in all eight of the national parks and preserves. The other study collected samples of air, water, snow, sediment, lichens, conifer needles, and fish at remote alpine, subarctic, and arctic sites. Researchers found that these samples contained four current-use pesticides including dacthal (DCPA), chlorpyrifos, endosulfans, and y-hexachlorocyclohexane (HGH) as well as four historic-use pesticides including dieldrin, a-HCH, chlordanes, and hexachlorobenzene (HCB). Pesticide concentrations in snow are highest in Sequoia, Kings Canyon, Rocky Mountain and Glacier National Parks. Concentrations in vegetation are mostly dominated by endosulfan and dacthal, and are highest in Yosemite, Kings Canyon, Glacier, and Great Sand Dunes National Park and Preserve. Fish samples also show elevated concentrations of dieldrin and DDT (one of the first pesticides to be banned in 1972 because of Rachel Carson’s Silent Spring). Cold temperatures in alpine or arctic ecosystems tend to concentrate pesticides, which can also bioaccumulate in the local […]

(Beyond Pesticides, June 17, 2009) A new study finds that toxic pesticides, including those already banned, persist in homes. The study’s results indicate that most floors in occupied homes in the U.S. have measurable levels of insecticides that serve as sources of exposure to home dwellers. These persistent residues continue to expose people, especially vulnerable children, to the health risks associated with these chemicals. Published in Environmental Science and Technology, the study, entitled “American Healthy Homes Survey: A National Study of Residential Pesticides Measured from Floor Wipes,” was conducted as a collaboration between the U.S. Environmental Protection Agency (EPA) and the U.S. Department of Housing and Urban Development. Five hundred randomly selected homes were sampled using alcohol wipes to collect dust from hard surface floors, mostly kitchen floor surfaces. The swipes were analyzed for 24 currently and previously use residential insecticides in the organochlorine, organophosphate, pyrethroid and phenylpyrazole classes, and the insecticide synergist piperonyl butoxide. Researchers found that currently used pyrethroid pesticides were, not surprisingly, at the highest levels with varied concentrations. Fipronil and permethrin, both currently used, were found in 40 percent and 89 percent of homes respectively. However, the researchers found that long discontinued pesticides like DDT and […]

(Beyond Pesticides, June 6, 2008) A recent study by the National Institutes of Health (NIH), including the National Institute of Environmental Health Sciences (NIEHS) and the National Cancer Institute (NCI), finds pesticide applicators with regular exposure to pesticides to be at a greater risk of type-2 diabetes. Published in the American Journal of Epidemiology (DOI: 10.1093/aje/kwn028), the study shows specific pesticides produce between a 20 and 200 percent increase in risk. Researchers looked at data from 31,787 pesticide applicators in North Carolina and Iowa over a period of five years. In that period, 1,171, or 3.7 percent, had developed diabetes, particularly for applicators in the highest category of lifetime days of use of any pesticide. “The results suggest that pesticides may be a contributing factor for diabetes along with known risk factors such as diabetes, lack of exercise and having a family history of diabetes,” said Dale Sandler, PhD, chief of the Epidemiology Branch of NIEHS. “Although the amount of diabetes explained by pesticides is small, these new findings may extend beyond the pesticide applicators in the study.” Freya Kamel, PhD, of NIEHS noted that “all of the seven pesticides” associated with an increased risk of type 2 diabetes are […]

(Beyond Pesticides, January 29, 2008) University of Cambridge scientists say there may be a link between persistent organic pollutants (POPs), including pesticides, and Type 2 Diabetes. The Cambridge scientists are advocating additional research into the little understood links between environmental pollution and adult onset diabetes. In the most recent edition of the journal Lancet, Oliver Jones, Ph.D., and Julian Griffin, Ph.D., highlight the need to research the possible link between persistent organic pollutants (POPs, a group which includes many pesticides) and insulin resistance, which can lead to adult onset diabetes. In their commentary, Dr. Jones and Dr. Griffin cite peer reviewed research including that of D. Lee, et al, which demonstrated a very strong relationship between the levels of POPs in blood, particularly organochlorine compounds, and the risk of type 2 diabetes. “Of course correlation does not automatically imply causation,” says Dr. Jones. “But if there is indeed a link, the health implications could be tremendous. At present there is very limited information. Research into adult onset diabetes currently focuses on genetics and obesity; there has been almost no consideration for the possible influence of environmental factors such as pollution.” Interestingly, in the Lee study an association between obesity and […]

(Beyond Pesticides, December 17, 2007) People exposed to banned organochlorine pesticides and other toxic chemicals that persist in the environment are more likely to develop non-Hodgkin lymphoma (NHL), according to new research funded by the British Columbia Cancer Agency. The study, “Organochlorines and risk of non-Hodgkin lymphoma”, was published in the International Journal of Cancer on December 15, 2007 and is so far the largest to examine organochlorines in plasma and their link to illness. The researchers measured the levels of pesticides or pesticide metabolites and congeners of polychlorinated biphenyls (PCBs) in the blood of 880 British Columbians, half with NHL and the other half control subjects. Several pesticide analytes and a number of congeners showed a significant association with NHL. Non-Hodgkin lymphoma is the fifth most common cancer in Canada and the most common type of lymphoma. “We know that the incidence of non-Hodgkin lymphoma has been steadily rising for the past 30 years worldwide, but there hasn’t been clear evidence to explain the increase,” says Dr. John Spinelli, Ph.D., lead author and a senior scientist at the BC Cancer Agency. “Our study helps to provide answers to this puzzle by showing a strong link between these specific environmental […]

(Beyond Pesticides, July 2, 2007) Dangerous pesticides have been found in soil samples taken from the grounds of the West Brook Middle School in Paramus, New Jersey. The concentrations found exceed state safety standards and concerns are being raised over why the school took no action once it knew about the contaminants. One of the chemicals found is chlordane. Chlordane is an organochlorine classified by the EPA as a Group B2, probable human carcinogen and is also associated with adverse neurological and gastrointestinal effects. Studies also report an association between chlordane exposure and non-Hodgkins’s lymphoma. Chlordane was registered in the U.S. in 1948 and was used as a pesticide on agricultural crops and gardens until 1978 when its registered uses on food crops and other above ground uses were cancelled. In 1988, all uses of chlordane were cancelled. This pesticide however, is persistent in soil and the environment and has been found in air samples, fish tissue, and recent studies have linked organochlorines like chlordane to breast cancer. The Record, a New Jersey newspaper, commissioned the tests to be carried out by Aqua Pro-Tech Laboratories, which revealed that chlordane at 17 parts per billion were on the school’s soccer field. […]

(Beyond Pesticides, January 30, 2007) Breast cancer groups across the country have a new issue to add to the repertoire of risk factors: Pesticide use. A study published online in the American Journal of Epidemiology has found a strong link between residential pesticide use and breast cancer risk in women. Responding to the study, Susan Teitelbaum, Ph.D., assistant professor in the department of community medicine at the Mount Sinai School of Medicine in New York, says the options are simple”” “Stop using pesticides.” The study, published December 13, is the first to examine the relation between breast cancer and pesticides through self-reported residential pesticide use. Using women from New York, the study looks not at one or two incidents of pesticide contact, but at the impact of lifelong pesticide use in the home, lawn and garden. Using a sample of 1,508 women who were diagnosed with breast cancer between 1996 and 1997, the study compares these women to 1,556 control subjects who were randomly selected. The results show that those women whose blood samples had higher levels of organochlorines are at an increased risk of breast cancer. Organochlorines are a broad class of chemicals, including DDT, dieldrin, and chlordane, and […]