25
Mar
(Beyond Pesticides, March 25, 2025) An editorial in Expert Review of Cardiovascular Therapy finds that triazole fungicides pose a significant risk of cardiotoxicity with “growing concerns regarding their safety for human health, especially in long-term exposure,†the authors share. After analyzing the known mechanisms of cardiotoxicity of triazole pesticides in mammals, they conclude that “the most effective approach to mitigating triazole-induced cardiotoxicity lies in prevention.â€Â Triazoles, a class of fungicides, target fungi by inhibiting the biosynthesis of ergosterol, an essential component of their cell membranes. As the researchers share, “Compounds such as tebuconazole, propiconazole, and difenoconazole are among the most used triazoles in agriculture.†Triazoles are utilized as antifungal medications, despite the rise of resistant infections, in addition to their use as systemic pesticides on many fruit and vegetable crops, including grapes, wheat, corn, and soybeans.  As Beyond Pesticides’ previous coverage indicates, many triazole fungicides in the U.S. are registered for use despite evidence of endocrine disruption established over a decade ago in a U.S. Geological Survey report. These pesticides exhibit common mechanisms of toxicity often disregarded in U.S. Environmental Protection Agency (EPA) risk assessments, with a multitude of studies showcasing the myriads of health threats that the agency does […]
Posted in Cardiovascular Disease, difenoconazole, Endocrine Disruption, Fungicides, Oxidative Stress, Propiconazole, tebuconazole | No Comments »
11
Mar
(Beyond Pesticides, March 11, 2025) A study in Toxics analyzes ipconazole, a triazole fungicide often used as a coating on treated seeds and as a foliar treatment on the leaves of plants. “Triazole pesticides are widely used throughout the world, but their abuse causes toxic effects in non-targeted organisms,†the researchers state. In the current study, unintended reproductive effects are noted in male sheep (ram) and pigs (also known as porcine or swine). This research focuses on the impact of ipconazole exposure on spermatozoa (sperm) in two mammal species and finds spermiotoxicity through significantly reduced sperm viability, as well as alterations in enzyme and gene expression related to fertility. “To our knowledge, this is the first study to evaluate the cytotoxic effect of the triazole ipconazole on mammalian spermatozoa,†the authors share. This analysis utilizes semen samples from the Reproductive Biotechnology Laboratory of the Major National University of San Marcos in Lima, Peru, the university where six of the nine researchers are Faculty of Veterinary Medicine.  “The sperm were exposed to ipconazole concentrations of 1, 5, 10, 50 and 100 µM, and to a control without ipconazole,†they say. Similar concentrations have been used in previous cytotoxicity studies with ipconazole. […]
Posted in difenoconazole, Endocrine Disruption, Epigenetic, Infertility, Ipconazole, Livestock, men's health, Oxidative Stress, Peru, Reproductive Health, tebuconazole | No Comments »
03
Dec
(Beyond Pesticides, December 3, 2024) In an article in Science, Sabrina Rondeau, PhD reviews her research from 2022-2024 showcasing species of ground-nesting bees, often found in crop fields, that are highly vulnerable to soil pesticide residues and subsequently suffer population declines. Dr. Rondeau, a postdoctoral fellow in the Department of Biology at the University of Ottawa, points to regulatory deficiencies, specifically in environmental risk assessments (ERAs), and the detrimental effects of pesticides on pollinators that threaten food security and biodiversity. “Modern intensive agriculture faces a critical paradox: The very pesticides designed to protect our crops endanger essential pollinators that sustain their productivity,†Dr. Rondeau says in the article. Her research (see here, here, here, here, here, and here) identifies important gaps overlooked in current assessments and regulations for bee species, including the common eastern bumble bee (Bombus impatiens) and the hoary squash bee (Xenoglossa pruinosa). Bumble bee queens in temperate climates hibernate for 6-9 months in the soil, while the hoary squash bee is a solitary ground-nesting species. Reference additional Daily News coverage on ground-nesting bees here and here. “‘Our findings show that over 70% of wild bee species, which are crucial for pollinating our food crops, face significant risks […]
Posted in Azoxystrobin, Beneficials, Biodiversity, Cyantraniliprole, difenoconazole, Ecosystem Services, Environmental Protection Agency (EPA), flupyradifurone, Pollinators, soil health, Wildlife/Endangered Sp. | 2 Comments »
24
May
(Beyond Pesticides, May 24, 2024) Even allegedly “low-toxicity†pesticides such as flupyradifurone (insecticide), azoxystrobin, and difenoconazole (fungicides) pose adverse health effects to solitary ground-nesting squash bees (Xenoglossa pruinose), according to a study published in Biological Sciences. Fungicide exposure led to less pollen collected per flower, while exposure to flupyradifurone (FPF) produced larger offspring (which make it more challenging for them to fly). Simultaneous exposure to the three pesticides “induced hyperactivity in female squash bees relative to both the control and single pesticide exposure, and reduced the number of emerging offspring per nest compared to individual pesticide treatments.†With United Nations Food and Agriculture Organizations-sponsored World Bee Day earlier this week, now more than ever advocates are calling for the elimination of toxic insecticide classes, such as neonicotinoids and butanolides, and their wholesale replacement with organic land management principles. This study was written by Sabrina Rondeau, PhD, postdoctoral Fellow in the Department of Biology at the University of Ottawa, and Nigel E. Raine, PhD, professor at University of Guelph’s School of Environmental Science. Published on March 20, 2024, the researchers delve into the individual and co-exposure impacts of two fungicides and one insecticide, which is important, given the documented synergistic effects […]
Posted in Azoxystrobin, Chemical Mixtures, difenoconazole, flupyradifurone, Fungicides, neonicotinoids, Pollinators, Uncategorized | No Comments »
01
Mar
(Beyond Pesticides, March 1, 2023) Fungicides sprayed on chemically farmed strawberries reduce their flavor quality, according to research published in the Journal of Agricultural and Food Chemistry this week. This explanation is a major insight for frustrated consumers who may remember when the strawberries sold at retail contained deeper, more complex flavors. As the agrichemical industry claims that dangerous pesticides are needed to grow food to feed the world, it is evident these practices health and environmental hazards, but also affect the quality of the food grown. As savvy shoppers and gardeners already know, buying and growing organic addresses this range of issues, improving flavor while protecting wildlife and public health. Scientists developed their study to better understand the mechanisms leading to flavor deterioration by growing strawberry plants in a greenhouse with chemical-intensive practices, including the use of synthetic fertilizers. One group was treated with the fungicide boscalid, another with the fungicide difenconazole, and a control group received no spray. Fruits were sprayed beginning at the green, small fruit stage, a total of two times, and collections from each group were taken at the white, turning, and red fruit stage (zero, three, and seven days after the second pesticide application). […]
Posted in Agriculture, Alternatives/Organics, boscalid, difenoconazole, Fungicides, Uncategorized | No Comments »
