(Beyond Pesticides, July 30, 2020) Simultaneous exposure to pesticides and noise from agricultural machinery increases farmworkers, risk of hearing loss, according to the study, “Hearing Loss in Agricultural Workers Exposed to Pesticides and Noise,” published in the journal Annals of Work Exposures and Health. Hearing loss is the 3rd most common health issue in the U.S., affecting eight million Americans. Although specific conditions like age, illness, and genetics, can mediate hearing loss, research suggests other factors can induce auricle (ear) damage, including medications, exposure to toxic chemicals (including pesticides), and loud, ongoing noise. Past studies find an association between hearing loss and pesticide exposure or noise exposure, alone. However, this study is one of the first to associate hearing loss with the additive effect to concurrent, persistent pesticide exposure, and noise. This research is significant as human senses are integral to everyday human activities, and it is vital to understand how chronic pesticide exposure can limit the body’s ability to function normally, for farmers and everyone alike. Researchers in the study note, “[I]t is necessary to understand what work-related factors are contributing to this high prevalence of hearing loss in [Thai] agricultural workers in order to develop effective interventions and […]

(Beyond Pesticides, July 10, 2020) A study published in June 2020 in Environmental Health journal is especially concerning for people who become, or plan to become, pregnant. It concludes that personal, agricultural, and household exposures to pesticides may increase the risk of a relatively rare fetal disorder called “holoprosencephaly.” The study finds that pre-conception and the first few weeks of pregnancy are the most vulnerable periods during which exposure can increase risk of this disorder, in which the embryo’s forebrain fails to develop into two distinct hemispheres. The study’s results reinforce Beyond Pesticide’s long-standing warnings of the dangers of pesticides to children and the necessity of shifting to a precautionary approach to the introduction and use of synthetic pesticides (and other chemicals) across all sectors. The importance of this shift is perhaps no more poignantly illustrated than in the impacts that pesticide exposure can have on new life. The study, conducted from 2016 through 2019 by researchers from NIH (the U.S. National Institutes of Health) and the University of Wisconsin–Madison, is a case-control study — one that compares subjects who have a disease or disorder with “controls” who do not have the disorder, comparing the frequency of exposure to a particular risk […]

(Beyond Pesticides, April 23, 2020) Pesticide spray drift from adjacent farmlands expose butterfly larvae to lethal pesticide concentrations, according to research published in Environmental Toxicology and Chemistry by Iowa State University (ISU). Lack of previous experimental pesticide toxicity data makes it unclear as to what degree insecticides impact monarch butterfly (Danaus plexippus) productivity in milkweed (Asclepias spp.) habitats near pesticide-treated pasture. This study adds weight to the idea that pesticides are playing a role in the ongoing decline of this iconic butterfly, as researchers find insecticide drift from adjacent fields to be strongly associated with larval mortality. Future monarch butterfly conservation efforts should consider risks stemming from pesticide exposure when developing butterfly rehabilitation efforts, according to advocates. As co-author Niranjana Krishnan (ISU graduate student) states, “In order to make the best decisions about how and where to plant milkweed, we first need to find basic toxicity and exposure data.”  ISU researchers established monarch butterfly colonies by collecting larvae from roadside milkweeds, which they then reared in the laboratory for incubation. To analyze the relative toxicity of various insecticides on monarch butterflies, researchers applied normal field-application rates of each pesticide at different larval development stages. Scientists used a bioassay to measure the […]

(Beyond Pesticides, March 18, 2020) Freshwater habitats are threatened now—more than ever—by the adverse effects of pesticide pollution, according to a report published in Scientific Reports by a collaborative research team from the Helmholtz Centre for Environmental Research (UFZ) and the Kenya-based International Centre of Insect Physiology and Ecology (ICIPE). Pesticide pollution, attributed to runoff from agricultural farms, indirectly increased the rate of the tropical disease schistosomiasis, which infects over 280 million people (2018). This research underlines the range of uncertainties that exist as a result of pesticide contamination, making it critically important that subtropical areas where this disease threat exists move toward organic and pesticide-free approaches.  Increased prevalence of this disease is devastating to socioeconomic development in affected regions, as life expectancy, employment rate, and gross domestic product (GDP) decreases. Schistosomiasis (snail fever), or bilharzia, is a tropical disease caused by parasitic flatworms (trematodes) in the genus Schistosoma and transmitted via freshwater snail (genus Biomphalaria) to its definitive human host. Freshwater snails act as a vector for schistosomiasis as they play a vital role in the lifecycle of the parasitic flatworm. Professor Matthias Liess (Ph.D.), Head of the Department of System Ecotoxicology at the UFZ, and his research team investigated pesticide pollution’s […]

(Beyond Pesticides, February 13, 2020) Congress unanimously passed the Food Quality Protection Act (FQPA) in 1996 to increase protections for children from pesticide exposure. Unfortunately, according to a new study published in Environmental Health, the law is not being employed by the Environmental Protection Agency (EPA) to its full capacity. For most of the 59 pesticides reviewed by the study, EPA did not apply an additional FQPA safety factor and thereby missed an opportunity to protect children’s health. In fact, FQPA solidified EPA’s reliance on risk assessment calculations and mitigation measures that consistently fall short of adequate levels of protection because of serious data gaps, a failure to consider exposure to mixtures and synergistic effects, and a bias against consideration of alternatives (alternatives assessment)  that show toxic pesticides to be unnecessary.  FQPA establishes a safety standard applied to all food commodities that considers specific risks for infants and children. The law requires EPA to assess the “aggregate risk” (considering exposure from multiple sources) and “cumulative exposure” to pesticides that have a “common mechanism of toxicity.” FQPA mandates “an additional tenfold margin of safety for the pesticide chemical residue and other sources of exposure shall be applied for infants and children […]

(Beyond Pesticides, October 24, 2019) Fish and fruit are undoubtedly healthy foods, but modern-day contamination is leading scientists to caution pregnant mothers and young children to stick within current dietary guidelines, or switch to organic, in order to avoid adverse health effects. This new public health message is based on research published in the journal Environmental Health Perspectives by scientists from University of Southern California (USC) and several European Countries, finding that overconsumption of fish and fruits leads to higher levels of contamination with toxic persistent chemicals. “During gestation and early development, the fetus and the child, respectively, are vulnerable to the effects of environmental chemicals, said Lida Chatzi, MD, associate professor of preventive medicine at the Keck School of Medicine of USC. “A balanced diet during these periods is also critical for optimal nutritional status, but what to eat, and how much, are critical questions.” Scientists studied a cohort of 1,288 children (between 6 and 11 years) and 818 pregnant mothers from six European countries, who were provided questionnaires to assess their weekly diet. Blood levels of a range of environmental toxicants, including organochlorine compounds like PCB, PFHSs, PFOS, PFOA, pesticides like DDT and DDE, and heavy metals including […]

(Beyond Pesticides, September 24, 2019) In 2016, Canadians and Americans residing in Havana reported symptoms of headaches, dizziness, nausea. They described hearing strange buzzing and high-pitched sounds – some woke in the middle of the night fumbling for alarm clocks that were not going off. Media used the term “Havana syndrome” to describe the illness. Diplomats, scared by symptoms that seemed to only hit them in their hotel rooms or at home, speculated that a sonic weapon was being used against them. The Trump administration accused Cuban leaders of misconduct and removed all but essential employees. Later, some suspected that the diplomats could have experienced “mass hysteria.” A new Canadian study provides a more likely explanation to this mysterious illness that impacted diplomats in Havana: neurotoxic pesticide exposure. Researchers conducted testing on 14 individuals who had resided in Havana and a control group of 12 that had never lived there. Some of the experimental group had been recently exposed while others, tested 19 months after their return, were classified as “remotely exposed.” Tests included brain imaging and self-reported symptom questionnaires. They analyzed blood samples for routine biochemistry, kidney, liver, and metabolic functions. Individuals that showed symptoms of brain injury went […]

(Beyond Pesticides, August 30, 2019) The indictment of organophosphate pesticides gained more traction with the publication, in the Proceedings of the National Academy of Sciences, of a new research study out of the University of California, Berkeley. The research, among the first to use advanced brain imaging to assess cortical activation, shows altered brain activity, during tasks that call on executive function, in teenagers from California’s Salinas Valley (the site of significant organophosphate use) whose mothers were exposed prenatally. The UC Berkeley study underscores the slow-motion calamity of the Trump administration Environmental Protection Agency’s (EPA’s) failure to ban the use of this class of pesticides, and of chlorpyrifos in particular, which compounds carry extreme risks for children. The effects of this prenatal exposure continue to unfold during children’s critical developmental periods. Researchers used fNIRS (functional near-infrared spectroscopy) imaging to monitor blood flow in the brains of the teens, 15–17, born and raised in the Salinas Valley. They used data from the California Pesticide Use Reporting program (which documents locations and times of pesticide spraying) to estimate the subjects’ mothers’ proximity to organophosphate (OP) applications during pregnancy. The subject adolescents — estimated to have relatively high levels of prenatal exposure to organophosphates — […]

(Beyond Pesticides, August 15, 2019) An article in the journal Plos One, “An assessment of acute insecticide toxicity loading (AITL) of chemical pesticides used on agricultural land in the United States,” shows that recent shifts in insecticide use—from organophosphates and carbamates to synthetic pyrethroids and neonicotinoids—have made a large contribution to the ongoing insect apocalypse. This shift to insecticides that target insects based on both selective toxicity and delivery method occurs within a context of shrinking habitat and biodiversity. The study, by Michael DiBartolomeis, PhD, Susan Kegley, PhD, Pierre Mineau, PhD, Rosemarie Radford, and Kendra Klein, PhD, presents a measure of acute insecticide toxicity loading that incorporates acute toxicity, quantity used, and the rate at which the insecticide degrades. Goulson et al. applied a similar measure in Great Britain that did not incorporate the rate of degradation. Both studies use the median lethal dose (LD50) to honey bees as a measure of acute toxicity and calculate the potential number of bee deaths based on the number of lethal doses of various insecticides applied in the field. In both cases, researchers used toxicity estimates for honey bees because they are widely available. Other insects may be more or less sensitive. The […]

(Beyond Pesticides, July 11, 2019) Pregnant mothers with higher concentrations of pesticide metabolites (breakdown products) in their urine are more likely to have children who develop symptoms of Attention Deficit/Hyperactivity Disorder (ADHD), according to research conducted by the University of Southern Denmark and Odense University Hospital. The results of this study are consistent with past findings from Rutgers University and Cincinnati Children’s Medical Center, indicating a need for researchers to determine causality, and pesticide regulators to rein in toxic insecticide use. The pesticides investigated by researchers were breakdown products of the organophosphate chlorpyrifos, and the synthetic pyrethroid class of insecticides. The residue of these chemicals are frequently detected on conventional, industrially farmed food products. Although chlorpyrifos is banned from residential use in the U.S., most household bug sprays such as RAID contain high amounts of synthetic pyrethroids. Among the 948 pregnant Danish women tested, 90% had some level of chlorpyrifos metabolites (3,5,6-trichloro-2-pyridinol) detected in their urine, and 94% were positive for the generic pyrethroid metabolite (3-phenoxybenzoic acid). Scientists continued to follow up with pregnant women’s children through the first five years of life. A child behavioral check list was completed to determine the relative level of ADHD symptoms. Concentrations of […]

(Beyond Pesticides, June 26, 2019)  “We were drooling excessively. My eyes would not stop watering,” Kaylynn Knull said to Denver ABC7, after she and her boyfriend filed suit against a Dominican Republic resort they claimed poisoned them with toxic pesticides. This year, the same resort, the Grand Bajia Principe, has had three Americans die on its premises. This is not the first time an island resort has been implicated in improper, potentially illegal pesticide use. In 2015, a family of four was poisoned by Terminix after the highly toxic fumigant methyl bromide was applied in a nearby room seeped in while they slept. Ms. Knull told ABC7 that the couple’s symptoms began after rejecting a time share offer at the resort. “As soon as we came back to the room, we noticed it smelled like somebody had dumped paint everywhere. I was having the worst intestinal cramping I have ever experienced. It felt like a chainsaw going through my gut.” The couple booked the first flight off the island, and went to a doctor, who diagnosed them with “Likely Organophosphate poisoning.” Organophosphates are acutely toxic insecticides that bind to and block the transmission of the acetylcholinesterase, an enzyme important to […]

(Beyond Pesticides, March 1, 2019) The costs of pesticide use extend far beyond the invoices farmers pay for purchase of the chemicals to use on their crops. The real costs related to pesticide use and exposure include those of health care, lost productivity and income, and environmental damage (loss of environmental services and biodiversity; compromised air, water, and soil quality). There has been relatively little research focused on those real and extensive costs; this Daily News Blog turns its attention to several that have made the attempt. January 2019 saw the publication of a new book, Sicker Fatter Poorer: The Urgent Threat of Hormone-Disrupting Chemicals to Our Health and Future … and What We Can Do About It, by Leonardo Trasande, MD, MPP, which examines how some chemicals — including organophosphate and organochlorine pesticides — disrupt human endocrine (hormonal) function, and damage health, sometimes irreparably. The book further investigates the economic costs of associated diseases and other health problems to the U.S. economy — on the order of 2.3% of GDP (gross domestic product), or $340 billion, annually. As Dr. Trasande notes, “The reality is that policy predicts exposure, exposure predicts disease and disease ultimately costs our economy.” Dr. Trasande is […]

(Beyond Pesticides, February 15, 2019) A study, published in January 2019 in the journal Environmental Health, demonstrates that consumption of organic foods reduces significantly the levels of synthetic pesticide residues in the bodies of U.S. children and adults. Pesticide residues are found four times as frequently in conventionally grown food as in organically produced foodstuffs. Although the number of subjects in this study was relatively small, the results point to the importance of organics, and add to the evidence that organic food production and consumption are key to protecting human health. Study subjects comprised members of racially diverse families — from Oakland, Minneapolis, Baltimore, and Atlanta — who did not typically consume an organic diet. Study participants, ages 4 to 52, ate their typical diet of conventionally grown foods for five days; for the following six days, they switched to a certified organic diet (provided by researchers) for consumption at home, work, school, or daycare, including all foods and beverages other than water. Urine samples were gathered prior to the “organic” days, and first thing on the morning after those six days. Fourteen different pesticides and metabolites were present in all participants’ urine in the “pre-organic” analysis; following the organic diet […]

(Beyond Pesticides, November 20, 2018) Scientific conclusions used to support the registration of the insecticide chlorpyrifos were flawed and omitted key health impacts, according to a fresh analysis of the original data by a team of independent scientists from northern Europe and the U.S. This re-review not only casts further doubt on the safety of the neurotoxic chlorpyrifos, it highlights a major flaw within federal pesticide regulation that allows pesticide producers to submit their own safety evaluations to the U.S. Environmental Protection Agency without public oversight. “One conclusion we draw is that there is a risk that the results of industry-funded toxicity tests are not reported correctly,” says co-author Axel Mie, PhD. “This makes it difficult for the authorities to evaluate the pesticides in a safe and valid way.” In both the U.S. and European Union, pesticide producers contract with laboratories to perform required safety tests of active ingredients they hope to register for use. While these studies are generally considered ‘confidential business information’ and not available to the public, using Swedish freedom of information laws, researchers were able to obtain two key studies relating to the developmental neurotoxicity of chlorpyrifos. Although not disclosed within the study, it is well […]

(Beyond Pesticides, November 2, 2018) A group of leading toxics experts, who published a paper in the journal PLOS Medicine on their research on organophosphate exposure during pregnancy and impacts on child development, are calling for a ban on organophosphate pesticides. The study evaluates current science on the risks of this class of compounds, produced by Corteva Agriscience (formerly Dow AgroSciences); its conclusions warn of the multitude of dangers of organophosphates for children, and makes recommendations for addressing these risks. The experts conclude that: (1) widespread use of organophosphate (OP) pesticides to control insects has resulted in ubiquitous human exposures; (2) acute exposures to OPs is responsible for poisonings and deaths, particularly in developing countries; and (3) evidence demonstrates that prenatal exposures, even at low levels, put children at risk for cognitive and behavioral deficits, and for neurodevelopmental disorders. Among the authors’ recommendations are these: Governments and subsidiary agencies, including the Environmental Protection Agency (EPA), should phase out chlorpyrifos and other organophosphate pesticides; ban non-agricultural uses of OP pesticides (including in household products); monitor watersheds and drinking water sources of human exposure; promote the use of integrated pest management (IPM) through incentives and training; and establish pesticide use and illness reporting […]

(Beyond Pesticides, October 18, 2018) Pesticide residue doesn’t announce itself –it isn’t colored, it doesn’t glow or reflect light, and after an initial application doesn’t put out a discernible odor – but it is likely ubiquitous in rural U.S. homes, according to a study published by Cornell University researchers late last month. The study is a warning specifically to households with young children, who are at increased risk of health effects from even minute levels of pesticide exposure. “Numerous health problems occur from exposure to pesticides, such as cancer, birth defects, leukemia and ocular [vision-related] toxicity, among a number of other health issues,” said Joseph Laquatra, PhD, coauthor of the research. “Households with crawling toddlers should be concerned, as toddlers will accumulate pesticide residues on their hands and then ingest them due to hand-to-mouth behaviors.” Researchers focused in on 132 households in rural counties of New York State that agreed to test for pesticide residue inside their home. Wipe samples were collected from both carpeted and non-carpeted areas, and tested for pesticides used commonly as part of agricultural production in the region. The pesticides analyzed included 15 compounds ranging from organophosphates like chlorpyrifos and malathion, to synthetic pyrethroids like resmethrin, […]

(Beyond Pesticides, August 29, 2018) As pesticides drain from agricultural fields, they can poison waterways and coastal areas and harm wildlife. Now, a study finds that a gene that helps terrestrial mammals break down certain toxic chemicals appears to be faulty in marine mammals — potentially leaving manatees, dolphins and other warm-blooded aquatic life more sensitive to toxic pesticides, especially organophosphates. As marine mammals evolved to make water their primary habitat, they lost the ability to make a protein that has the effect of defending humans and other land-dwelling mammals from the neurotoxic effects of certain pesticides. The gene, PON1, carries instructions for making a protein that interacts with fatty acids ingested with food. But that protein has taken on another role in recent decades: breaking down toxic chemicals found in a popular class of pesticides – organophosphates. An inspection of the genetic instructions of 53 land mammal species in the study, “Ancient convergent losses of Paraoxonase 1 yield potential risks for modern marine mammals,” found the gene intact. But in six marine mammal species, Paraoxonase 1 (PON1) was riddled with mutations that made it useless. The gene became defunct about 64 million to 21 million years ago, possibly due to dietary or behavioral changes related to […]

(Beyond Pesticides, January 8, 2018)  With a long-documented history of children’s exposure to pesticides that drift from agricultural fields to school yards, California’s new regulations establishing no-spray buffers took effort January 1, as labor and public health groups acknowledged the progress and inadequacy of the measure. The new rule, DPR 16-004 Pesticide Use Near Schoolsites, adopted by the California Department of Pesticide Regulation (DPR), prohibits many pesticide applications within a quarter mile of public K-12 schools and licensed child day-care facilities during school hours, Monday through Friday between 6 a.m. and 6 p.m. This includes all applications by aircraft, sprinklers, air-blast sprayers, and all fumigant applications. In addition, most dust and powder pesticide applications, such as sulfur, will also be prohibited during this time. The new rule was announced in November, 2017. Advocates say the new rules fail to address persistent low-level exposures associated with the use of the pesticides near schools, which are in agricultural areas that are disproportionately Latino and from farmworker families. There is continuing concern about children’s exposure to hazardous pesticides because children use school grounds after school hours and on weekends and residues from drift may remain on school grounds. Many pesticides used are persistent and systemic, lingering […]

(Beyond Pesticides, May 12, 2017) Researchers from the University of California San Diego, School of Medicine, in collaboration with scientists from Ecuador and Minnesota, have found that exposure to heavy pesticide use during peak periods can impact neurobehavioral performance in children. The study focused on exposure to organophosphate pesticides, which have been associated with a broad range of diseases in both children and adults. The study, published in NeuroToxicology, involved 308 non-worker Ecuadorian children between the ages of 4 and 9. Neurobehavioral performance for each child was tested once between 63 and 100 days after the Mother’s Day flower harvest, which is a period of high pesticide use in Ecuador. The researchers found that children examined sooner after Mother’s Day had lower scores than children who were tested later. “Children examined sooner after the flower harvest displayed lower performance on most measures, such as attention, self-control, visuospatial processing (the ability to perceive and interact with our visual world) and sensorimotor (eye-hand coordination) compared to children examined later in a time of lower flower production and pesticide use,” said Jose R. Suarez-Lopez, MD, PhD, and lead author of the study, to ScienceBlog. Dr. Suarez-Lopez continued, “This discovery is novel because it […]

(Beyond Pesticides, March 21, 2017) Last week, the California Department of Pesticide Regulation (CDPR) released revised rules regarding notification of pesticide applications near schools, weakening standards despite opposition from community and public health groups. The new rules rescind a requirement that schools be granted 48 hours prior notification for a planned application of agricultural pesticides within ¼ mile of a school site. CDPR has re-opened public comments on the new rules, and concerned residents have until April 4 to submit a short statement urging increased protections to the Department at [email protected]. Public health, farmworker, and community groups had urged CDPR to strengthen, not weaken common-sense protections for children’s health. As the rules currently stand, applications of toxic, drift-prone pesticides will only be restricted within ¼ mile of a school site, and only during the hours of 6am to 6pm on weekdays. The original proposal required 48 hour prior notification for other agricultural pesticide applications occurring within ¼ mile of school sites during these times. However, CDPR’s revised rules now only require 48 hour notification if the pesticides applied are not on a list provided to school officials at the beginning of the year. Applicators will still be required to submit annual reports […]

(Beyond Pesticides, January 9, 2017) After the U.S. Environmental Protection Agency (EPA) released its recent human health risk assessment for the organophosphate insecticide (OP) tetrachlorvinphos (TCVP) on December 21, 2016, the agency announced it was allowing the continued use of the neurotoxic chemical to which children are widely exposed through pets’ flea collars and other flea treatments. According to EPA, ” TCVP is used as a direct animal treatment to livestock (i.e., cattle, horses, poultry and swine) and their premises, in kennels, outdoors as a perimeter treatment, and as a flea treatment [including flea collars] on cats and dogs.” In its announcement on January 4, 2017, EPA states, “We advise consumers to take certain precautions when handling TCVP products in residential areas. These precautions are listed on TCVP product labels, including: not allowing children to play with TCVP pet collar products, keeping TCVP spray and powder products out of reach of children, and washing hands thoroughly with soap and water after handling.” Advocates have raised concerns related to similar decisions on flea collars in the past in which EPA has issued warnings to mitigate risks, despite its inability to ensure children’s safety. Children typically come into close contact with pets and their […]

(Beyond Pesticides, November 15, 2016) Last week, the U.S. Environmental Protection Agency (EPA) updated its assessment of the toxic organophosphate insecticide chlorpyrifos, keeping in place a decision made last year to revoke food residue tolerances and effectively eliminate its use in agriculture. The agency indicated the change was necessary after a Scientific Advisory Panel convened by the agency suggested additional data to support its decision. This change opens up a 60-day public comment period, but EPA has said that it will make a final decision no later than March 31, 2017. “The revised analyses indicate that expected residues of chlorpyrifos on food crops exceed the safety standard under the Federal Food, Drug, and Cosmetic Act (FFDCA),” EPA noted in its announcement.  “In addition, the majority of estimated drinking water exposures from currently registered uses, including water exposures from non-food uses, continue to exceed safe levels even taking into account more refined drinking water exposures. “ To explain the decision to the public, EPA has put together a FAQ page on its website. EPA’s proposal to revoke chlorpyrifos’ food tolerances stems from a petition and lawsuit filed by the Natural Resources Defense Council and Pesticide Action Network North American nearly ten […]

(Beyond Pesticides, August 10, 2016) New research connects 78 pesticides commonly used by farmers with many adverse respiratory effects, including both allergic and non-allergic wheeze. The study, Pesticides Are Associated with Allergic and Non-Allergic Wheeze among Male Farmers, was led by NC State environmental epidemiologist, Jane Hoppin, ScD and colleagues from the National Institute of Environmental Health Sciences (NIEHS), the National Cancer Institute, Westat and the National Institute for Occupational Safety and Health (NIOSH). This is one of the most comprehensive evaluations of pesticides in relation to wheeze that has been evaluated to date, finding that several commonly used pesticides in both agriculture and residential settings can cause adverse respiratory effects. “Fifty-one of the pesticides we tested in this study had never been analyzed in terms of their effects on respiratory outcomes. And some of them, like glyphosate, 2,4-D and permethrin, aren’t just used on farms. They’re used residentially now to kill weeds or treat fleas on pets,” said Dr. Hoppin. “We believe it’s important information that will help people make decisions about pesticides.” Researchers used interview data from the 2005-2010 Agricultural Health Study (AHS) to assess the correlation between pesticide exposure and wheeze in male farmers. 22,134 farmers were […]