(Beyond Pesticides, December 2, 2025) Recently published in Reproductive Toxicology, researchers in Denmark and Iceland investigate the impacts of pesticides on sex hormones, finding that “prenatal exposure to [the insecticide] chlorpyrifos and [weed killer] 2,4-D may affect the reproductive hormones in girls, but not boys, during minipuberty, which may have long-term implications.” Based on their analysis of urinary maternal concentrations of the pesticides and their metabolites and hormone levels in infants, the authors report, “This study examined the association between maternal pesticide exposure and pituitary, gonadal, and adrenal hormones in offspring during infancy.” The sex-specific findings highlight a public health concern with potentially long-lasting transgenerational effects. “We recruited pregnant women from 2010 to 2012 in the Odense Child Cohort, including 489 mother-child pairs,” the authors state. They continue: “Maternal urinary concentrations of the generic pyrethroid metabolite 3-phenoxybenzoic acid (3-PBA), the chlorpyrifos metabolite 3,5,6-trichloro-2-pyridinol (TCPY), and the herbicide 2,4-D were measured at gestational week 28. Serum concentrations of luteinizing hormone (LH), follicle stimulating hormone (FSH), testosterone (T), estrone (E1), estradiol (E2), 17-hydroxyprogesterone (17-OHP), Androstenedione (Adione), and Dehydroepiandrosterone sulfate (DHEAS) were assessed in infancy.” The results of the analyses show that in girls, higher maternal urinary TCPY and 2,4-D concentrations are significantly […]

(Beyond Pesticides, November 13, 2025) A study in Environmental Science & Technology shows that maternal exposure to organophosphate (OP) and pyrethroid insecticides adversely affects newborn health. Through amino acid and acylcarnitine metabolomics (the study of small molecules known as metabolites) with over 400 mother-infant pairs, this research analyzes metabolic pathways linking pesticide exposure to negative birth outcomes. “To our knowledge, this study is the first to reveal the effect of OP and pyrethroid insecticide exposure on neonatal metabolic signatures, which may elucidate a key role of metabolites in insecticide exposure and birth outcomes,” the authors state. In collecting maternal urine samples in the first and third trimesters, as well as neonatal blood samples after birth, OP and pyrethroid metabolites and metabolomic biomarkers are assessed. Notably, the authors report: “Results indicated that third-trimester maternal urinary levels of 3- phenoxybenzoic acid (3-PBA) and diethyl dithiophosphate (DEDTP) were negatively associated with birth weight. Specifically, a one-unit increase in their ln-transformed [natural logarithm form] concentrations was associated with a 1.508% decrease in birth weight for 3-PBA and a 1.366% decrease for DEDTP.” Additionally, the analyses show that OP and pyrethroid exposure is associated with “disrupted neonatal amino acids and acylcarnitine profiles, with patterns varying […]

(Beyond Pesticides, November 7, 2025) There is little dispute that modern industrial culture has produced a constellation of related chronic conditions contributing powerfully to human disease. In recent decades, attention has begun to focus on the developmental origins of health and disease—prenatal exposures to pesticides, for example, that contribute to diseases in adulthood, such as cardiovascular and metabolic problems, along with the combination, known as cardiometabolic syndrome. Cardiometabolic disorders include obesity, hypertension, cholesterol imbalances, and insulin resistance. The usual suspects blamed for the syndrome are poor diet, physical inactivity, and genetic predisposition. These are all well-established risk factors, but they fail to fully account for the sharp rise in cardiometabolic syndrome globally. Obesity prevalence has doubled and diabetes quadrupled over the last 40 years, according to the Non-Communicable Diseases (NCD) Risk Factor Collaboration. In a study on early life exposure to a pesticide mixture, researchers analyze sex differences in cardiometabolic outcomes from prenatal and early life. The study was conducted by an international team of scientists led by Ana M. Mora, M.D., of the Center for Environmental Research and Community Health at the University of California, Berkeley, using data from the Center for the Health Assessment of Mothers and Children of […]

(Beyond Pesticides, October 24, 2025) A literature review published in Science of the Total Environment reports numerous peer-reviewed studies associating prenatal and childhood pesticide exposure to measurable alterations to children’s immune systems, including indicators of immunosuppression and increases in pro-inflammatory cytokines, among other adverse health effects. These immune system alterations are linked to higher infection risk and potentially contribute to autoimmune diseases and allergies later in life. For over four decades, Beyond Pesticides has tracked the peer-reviewed science and identified a preponderance of evidence linking pesticide and chemical-dependent pest management to adverse human and ecological health effects. In this spirit, public health and environmental advocates continue to call for a wholesale transition to organic land management and organic pest management as biodiversity, public health, and climate crises continue to mount. This mission supports the growth of the Parks for a Sustainable Future Program, where nineteen cities in eleven states across the country engage in pilot projects to transition parks, playing fields, and schoolyards to organic management practices and protect the health of children. Background and Methodology “This study aimed to evaluate the extent of immunotoxicity and correlation between exposure to pesticides and immune system alterations in children under five years […]

(Beyond Pesticides, October 23, 2025) A global literature review of pesticide residues in marine seaweed, published in Marine Pollution Bulletin, highlights the widespread presence of pesticides in bioindicator species. As vital coastal primary producers, seaweed acts as a key indicator for regional pesticide contamination patterns. The bioaccumulation within seaweed species also threatens consumers, including humans, as the chemicals can biomagnify as they move through the food web. Pesticide contamination in waterways allows residues to bioaccumulate in seaweed species, presenting risks to public health, biodiversity, and ecosystem functioning. In addition to the support seaweeds provide for ecosystems, they provide food sources for a multitude of organisms and are of growing socioeconomic importance. “This systematic review identifies, critically evaluates, and synthesizes recent global literature (2015–2024) on pesticide residues detected in seaweeds to delineate contamination patterns,” the authors share. The findings highlight the harmful impacts of petrochemical pesticides on multiple species. Many aquatic species rely on seaweed as a food source, including fish, sea urchins, crabs, snails, brittle stars, and marine mammals such as manatees and sea turtles. Even bacteria and filter feeders consume seaweed when it is decomposed. Birds and land mammals also consume seaweed, including humans who utilize seaweed in various […]

(Beyond Pesticides, October 21, 2025) A study, published in International Journal of Hygiene and Environmental Health, calculates cumulative dietary pesticide exposure and finds a significant positive association between pesticide residues in food and urine when analyzing over 40 produce types. The research uses data for 1,837 individuals from the 2015–2016 National Health and Nutrition Examination Survey (NHANES) and compares them to biomonitoring samples of the participants. According to the researchers, “Here we show that consumption of fruits and vegetables, weighted by pesticide load, is associated with increasing levels of urinary pesticide biomarkers.” They continue, “When excluding potatoes, consumption of fruits and vegetables weighted by pesticide contamination was associated with higher levels of urinary pesticide biomarkers for organophosphate, pyrethroid, and neonicotinoid insecticides.” The NHANES data is derived from a national biomonitoring survey from the U.S. Centers for Disease Control and Prevention (CDC), which collects information about consumption of fruits and vegetables as well as urine samples. Background As the study authors explain: “Hundreds of millions of pounds of synthetic pesticide active ingredients are used every year in the United States, and pesticide exposure can occur through food, drinking water, residential proximity to agricultural spraying, household pesticide use, and occupational use. Pesticide […]

(Beyond Pesticides, September 5, 2025) A study in Journal of Agricultural and Food Chemistry finds permethrin, a commonly used synthetic pyrethroid insecticide, to be disruptive to the gut microbiome, altering microbiota and leading to increased formation of fat cells (adipogenesis) and metabolic disorders. With an aim to “comprehensively elucidate the effects of permethrin on gut microbiota, lipogenesis, and the associated molecular mechanisms,” the study explores the adverse effects of permethrin exposure in adult mice through multiple experiments. “Our study provides the first in vivo [in a living organism] evidence suggesting a potentially causal relationship between permethrin exposure and the development of obesity, potentially mediated by specific gut microbiota-derived metabolites,” the researchers explain. They continue, “Notably, this work is the first to define a distinct microbiota−metabolite−host axis as a critical mediator of environmental toxicant-induced metabolic dysfunction.” Permethrin is widely used as an insecticide on crops, such as cotton, corn, and wheat, as well as on livestock, in indoor and outdoor areas, and for treating lice and scabies. Mosquito abatement programs often utilize permethrin, further adding to the various exposure routes of this neurotoxic chemical. (See additional uses and health effects of permethrin in Beyond Pesticides’ Gateway on Pesticide Hazards and Safe […]

(Beyond Pesticides, August 15, 2025) In analyzing the data present in an article in Data in Brief, concerning levels of pesticide biomarkers are present in the urine of adolescents and young adults that are linked to numerous health implications. The biomonitoring data, collected at two time points from participants in a longitudinal cohort study in the agricultural county of Pedro Moncayo, Ecuador, encompasses a total of 23 compounds used as herbicides, insecticides, and fungicides and their associated metabolites (breakdown products), which include organophosphates, pyrethroids, and neonicotinoids. The results highlight the disproportionate risks to a Latin American population that occur as a result of living in areas with heavy chemical-intensive agriculture. “This article presents urinary pesticide metabolite concentrations for 665 participants in the ‘Study of Secondary Exposure to Pesticides among Children, Adolescents, and Adults’ (ESPINA), which were collected during two follow-up assessments,” the authors describe. The first sampling period from July to October 2016, referred to as Follow-up Year [FUY]-8b, includes 529 of the participants, while the second sampling period from July to September 2022 (FUY-14a) includes 505 of the participants. All participants are within the agricultural community of Pedro Moncayo. As the authors note, “The ESPINA study aimed to include […]

(Beyond Pesticides, August 12, 2025) Last week on August 9, the United Nations observed International Day of the World’s Indigenous Peoples, a critical acknowledgement of Indigenous “food sovereignty, food security, biodiversity conservation and climate resilience,” as outlined in the report of the Expert Mechanism on the Rights of Indigenous Peoples, Eighteenth Session (July 14–18, 2025). As the report states, under Article 20 of the UN Declaration on the Rights of Indigenous Peoples, “Indigenous Peoples possess distinct economic systems rooted in traditional knowledge, practices and resources and have the right to sustain, strengthen and develop these systems in accordance with their cultures, traditions, values and aspirations.” It continues, “When deprived of their means of subsistence and development, this article provides that Indigenous Peoples are entitled to just and fair redress.” In a statement recognizing the importance of the day, Special Rapporteur on the rights of Indigenous Peoples, Albert K. Barume, focuses on the need for Artificial Intelligence (AI) to recognize that, “Indigenous Peoples have long been stewards of knowledge, biodiversity, and sustainable living [and] [w]ithout their meaningful participation, AI systems risk perpetuating historical injustices and deepening the violation of their rights.” Meanwhile, the current U.S. administration has shifted away from federal […]

(Beyond Pesticides, August 7, 2025) The novel study published in Arthritis & Rheumatology is the largest investigation of rheumatoid arthritis (RA) in women to date, finding evidence of heightened risks when exposed to insecticides through data collected from over 400 eligible women in the Agricultural Health Study (AHS). AHS participants include a cohort of thousands of licensed pesticide applicators and their spouses from Iowa and North Carolina, with this particular study as the first to consider the link between pesticide exposure and RA as it affects women’s health.   “Growing evidence suggests farming and agricultural pesticide use may be associated with rheumatoid arthritis (RA), but few studies have examined specific pesticides and RA among farm women, who may personally use pesticides or be indirectly exposed,” the study authors explain. The findings reveal that organochlorine insecticides that continue to persist in the environment, as well as organophosphate and synthetic pyrethroid pesticides used in public health or residential settings, correlate with RA diagnoses in women.  As shared in previous Daily News, for the most part organochlorine pesticides, including dichlorodiphenyltrichloroethane (DDT), are no longer used worldwide, but the legacy of their poisoning and contamination persists. These compounds are primarily made up of chlorine atoms, […]

(Beyond Pesticides, July 16, 2025) A study following a mass mortality event of approximately 200 monarch butterflies (Danaus plexippus plexippus) in Pacific Grove, California, highlights the role of pesticides, synthetic pyrethroids in particular, in causing lethal and sublethal effects to nontarget organisms. The research, published in Environmental Toxicology and Chemistry, detects residues of 15 pesticides and associated metabolites in the bodies of 10 deceased butterflies collected from the January 2024 event that occurred near an overwintering site frequented by monarchs. “On average, each monarch butterfly contained 7 pesticides,” the authors report. They continue, “Notably, three pyrethroid insecticides—bifenthrin, cypermethrin, and permethrin—were consistently detected at or near each chemical’s lethal dose (LD50).” LC50, or Lethal Concentration 50, values represent the concentrations of chemicals lethal to 50% of a test population. To assess pesticide residues within ten of the deceased butterflies, the researchers use liquid and gas chromatography with tandem mass spectrometry (LC-MS/MS and GC-MS/MS) and find “a total of 15 pesticides and associated metabolites in the butterflies, including 8 insecticides (plus 1 associated metabolite), 2 herbicides (plus 2 associated metabolites), and 2 fungicides.” The study “present[s] evidence that the mortality incident at the Pacific Grove Monarch overwintering site was likely caused by […]

(Beyond Pesticides, July 15, 2025) A study published in Environmental Science and Technology finds that there are 47 current-use pesticides—products with active ingredients that are currently registered with U.S. Environmental Protection Agency (EPA) —detected in samples of indoor dust, drinking water, and urine from households in Indiana. This study builds on existing scientific literature documenting the public health threat of nonoccupational, indoor pesticide exposure. (See previous Daily News here, here, and here.) The study is a reminder that pesticides move into the indoor environment through the air, and on clothing, making exposure more widespread than the assumptions used in regulatory reviews. Background and Methodology “In this study, we collected matched samples of indoor dust, drinking water, and urine from 81 households in Indiana, United States, and analyzed these samples for 82 CUPs [current use pesticides], including 48 insecticides, 25 herbicides, and 9 fungicides,” say the authors. They continue: “Of these, 47 CUPs were identified across samples of indoor dust, drinking water, and urine with median total CUP (∑CUP) concentrations of 18 300 ng/g, 101 ng/L, and 2.93 ng/mL, respectively.” The herbicides (13) detected include 2,4-D (2,4-dichlorophenoxyacetic acid), Alachlor, Atrazine, CIAT (Desethyl-atrazine), Diuron, Metolachlor, Metolachlor OA (Oxanilic acid), OIAT (2-Hydroxy-4-isopropylamino-6-amino-s-triazine), OIET […]

(Beyond Pesticides, February 11, 2025) In a Science of The Total Environment study, scientists test over 100 blue tit (Cyanistes caeruleus) and great tit (Parus major) birds’ nests for pesticide residues in comparison with the number of dead offspring and unhatched eggs within the nest. Fur-lined nests, from animals treated with ectoparasitic chemicals, expose birds to compounds that can impact reproductive success. The authors found fipronil, a phenyl pyrazole insecticide, in all nests, with the majority also containing the neonicotinoid insecticide imidacloprid and synthetic pyrethroid insecticide permethrin. The data shows higher insecticide levels are linked to increased offspring mortality and threaten biodiversity. This study highlights an important exposure route that is overlooked. “Although not all bird species use fur for nest building, a substantial number do, especially cavity-nesting species,” the researchers share. “Previous research found that 74% of studied woodland bird species in central Europe incorporated fur into their nests.” Many bird species in the U.S. also line their nests with fur, such as black-capped chickadees, tufted titmice, and chipping sparrows. While there is a wide body of science showing reproductive effects from pesticides, the researchers highlight the study’s novel design, saying, “To the best of our knowledge, no previous […]

(Beyond Pesticides, February 7, 2025) With the strong associations established in epidemiologic studies and a dearth of evidence on the actual mechanisms by which pesticides inflict their damage on the brain, a new meta-analysis identifies studies that pesticides can overwhelm cells’ defenses against them, interfere with cell communication in the brain, and disrupt the epigenetic (gene function) regulation of gene expression. In the journal Nucleus, Bilal Ahmad Mir, PhD and colleagues at the University of Kashmir in Srinagar, India, review what is known at the molecular level about pesticides’ role in brain cancer. Brain cancer is a heavy burden for its victims and their families, and attributing a cause is, as with many diseases, fraught with difficulty. But there are strong clues: For example, farming is a known risk factor. In a 2021 meta-analysis of epidemiologic studies between 1998 and 2019, analyzed here by Beyond Pesticides, farming was associated with a 13% increase in the risk of brain cancer. For farmers whose specific exposure to pesticides was documented in the studies, the increase jumped to 20 percent. So there is some reason to point a finger at synthetic chemicals. But agricultural workers are not the only ones at risk. According […]

(Beyond Pesticides, December 12, 2024) A literature review of 161 articles in Discover Toxicology finds that pesticides with different mechanisms of action cause memory and learning impairments. These effects are noted in nontarget species including humans. Pesticide “[e]xposure during development, as well as chronic environmental and occupational exposure, can contribute to decreased cognitive performance,” the researchers say. With a focus on organophosphate pesticides, synthetic pyrethroids, and neonicotinoid insecticides, the authors highlight neurological impacts. Both learning and memory are crucial for the survival of many species. “Considering the importance of learning and memory for human and non-human animal behavior and the growing association between pesticide exposure and cognitive impairment, the aim of this review was to describe the studies showing the impact of pesticide exposure on memory and learning abilities in nontarget species, providing evidence of the impact of pesticides in central nervous system function,” the researchers state. The 161 articles included in the review were identified through database searches in PubMed/Medline and Scielo. The authors note, “Inclusion criteria for article selection included all articles published in English between 2015 and 2024 containing original studies in animals or humans with single or multiple pesticides exposure.” The articles consist of 132 preclinical […]

(Beyond Pesticides, October 8, 2024) A comprehensive literature review in Endocrines, published in September, amasses hundreds of studies on endocrine-disrupting chemicals (EDCs) that showcase adverse effects on growth, development, reproduction, and metabolism. The authors, a team of scientists and academics from Brazil, shed light on the link between EDC use and thyroid dysfunction, leading to increasingly prevalent illnesses and deadly diseases.     EDCs are any synthetic or natural compounds that hinder endocrine system functions and create harmful effects on organisms. These chemicals can impact the thyroid gland, which is vital in producing hormones and plays a role in several body functions. As the researchers state, “Several EDCs have been classified as thyroid disruptors, impairing thyroid hormone [TH] production, synthesis, metabolism, transport, and/or actions. Notably, thyroid disorders are the second most prevalent endocrine disease worldwide, with incidence increasing significantly in recent years.” The authors continue, “[S]tudies have correlated this rise in thyroid dysfunctions and cancers with increased exposure to EDCs. Although many EDCs are linked to thyroid dysfunction, this review focuses on the deleterious effects of plasticizers, organochlorine pesticides, and per- and poly-fluoroalkyl substances on thyroid function. These contaminants are commonly found in food, water, and everyday products.” This review helps […]

Image: Art Page submission from Sara Grantham, “Sunflower Pollinators”  (Beyond Pesticides, August 23, 2024) A study in Science of The Total Environment calculates and compares pesticide risk in 594 wild bee species associated with crops in North America. Current pesticide risk assessments that analyze effects on bees primarily focus on a limited subset of species and do not provide comprehensive protection of all wild bees. “Species commonly proposed as models for pesticide risk assessments may not accurately represent risk for those bee species facing the highest potential risk in agricultural contexts,” the authors postulate. The researchers continue, “This study presents a novel approach to characterize and compare the relative potential pesticide risk among wild bee species of their association with crops in North America using suites of intrinsic bee traits to quantify species’ vulnerability and extrinsic factors based on the toxic load of crops for bees and the strength of each species’ association with those crops.” In considering multiple factors that vary by species and determining potential harm to each from pesticide exposure, this study highlights the inadequacies of the current risk assessment process used by the U.S. Environmental Protection Agency (EPA).    The system for risk assessment for pesticides that […]

(Beyond Pesticides, August 22, 2024) A screening and analysis of 36 pesticides finds traces of these chemicals in patients with “unexplained chronic kidney disease” from agricultural communities in the Indian province of Uttar Pradesh. Researchers conducting this study, published in the Journal of Toxicology and Environmental Health Sciences, identify organophosphates, organochlorines, and pyrethroids as the main culprits, building on years of existing research pointing to adverse health impacts originating from bioaccumulation of pesticides after acute and chronic exposure. Chronic kidney disease (CKD) is a condition that afflicts one in ten adults internationally, based on a peer-reviewed analysis from The Lancet. The Centers for Disease Control and Prevention (CDC) estimate that one in seven U.S. adults (or roughly 35.5 million people) have CKD, with as many as nine in ten adults with the disease undiagnosed, based on 2023 data. The correlation between high rates of CKD and multigenerational use of and reliance on pesticides for food production, lawn care, and general land management reinforces the calls of advocates, farmers, and health professionals to adopt a new approach rooted in organic principles. Methodology This study was conducted by a group of researchers from the Department of Chemistry at Babu Banarasi Das University […]

(Beyond Pesticides, August 14, 2024) Pesticide exposure is linked to negative birth outcomes in a recent study in the American Journal of Epidemiology. This study adds to that body of science, but is novel research since, “Epidemiological studies of pesticide exposures and stillbirth in the United States have not been published in the past two decades, a time period that has seen dramatic changes in pesticide use compared to the 20th century,” the authors state. The study analyzes Arizona pesticide use records and birth certificates from 2006-2020. Researchers correlate mothers living within 500 meters of any pyrethroid, organophosphate (OP), or carbamate insecticide applications during specific windows before and during pregnancy with stillbirth. The authors focus on exposure during the prenatal period, as it is a susceptible time frame in which any contact with pesticides can negatively impact health. Numerous studies report several adverse birth and childhood outcomes with prenatal exposure. To link pesticide exposure and negative birth outcomes, Arizona records that encompass 1,237,750 births, 2,290 stillbirths, and 27 pesticides were analyzed. The authors “evaluate associations of pyrethroids, OPs, and carbamate insecticides with stillbirth by using data from the Arizona Pregnant women’s Environment and Reproductive outcomes Study (Az-PEARS), a project that […]

(Beyond Pesticides, January 26, 2024) In addition to maternal (mothers) exposure, children experience exposure to pyrethroid insecticides earlier in life as levels significantly increase post-natal (after birth), according to a study published in Frontiers in Public Health. This study is one of the few studies to investigate pyrethroid exposure concentrations in the urine of newborns and children within their first year of life. However, this research reiterates what many other studies demonstrate on pyrethroids’ impacts on children’s health, primarily due to their notorious neurotoxic properties. The findings indicate that exposure to pyrethroids during pregnancy and early childhood exposure has links to adverse health effects, including neurodevelopmental delays (e.g., autism), behavioral issues (e.g., attention deficit [hyperactivity] disorder), and endocrine disruption (e.g., delay in puberty). Pesticide exposure during pregnancy is of specific concern as health effects for all life stages can be long-lasting. Just as nutrients are transferable between mother and fetus, so are chemical contaminants. Studies find pesticide compounds in the mother’s blood can transfer to the fetus via the umbilical cord. Therefore, pesticide exposure during pregnancy affects both the mother and child’s health. Beyond Pesticides has covered a variety of pregnancy risks from pesticides and other toxic chemicals, including these in just […]

(Beyond Pesticides, January 24, 2024) A study published in Environmental Sciences Europe finds that 2,4-D, pyrethroid (PRY), and organophosphate (OP) pesticides increase the risk of cancer through oxidative stress (OS). The study highlights that pesticides that increase cancer risk also raise inflammation biomarkers that indicate damage to organs (e.g., liver) via oxidative stress. Additionally, different cancers show different sensitivities to pesticides; thus, cancer risk changes with exposure concentration and pattern. Despite a plethora of studies linking cancer and pesticide exposure, very few cover the mechanisms involved in cancer development, including OS. Only five to ten percent of cancers are hereditary. However, environmental or lifestyle factors, like chemical exposure, can make an individual more susceptible to cancer development through gene mutation. In fact, a vast amalgamation of research links cancer risk to pesticide exposure, which augments the risk of developing both common and rare cancers. Therefore, studies like this highlight the importance of understanding how pesticide use can increase the risk of latent diseases, which do not readily develop upon initial exposure. Using data from the National Health and Nutrition Examination Survey (NHANES), researchers investigated the link between the risk of several cancers and pesticide exposure. The researchers also thoroughly evaluated […]

(Beyond Pesticides, October 10, 2023) In recent years, the effects of climate change have become more frequent and more severe, from extreme weather events to rising sea levels. But perhaps one of the most insidious consequences of a warming planet is the way it influences the spread of diseases, often hitting marginalized communities the hardest. This is no more evident than in the case of malaria, where the disease transmission through the Anopheles stephensi mosquito serves as a dire warning of the challenges caused by a changing climate. As this deadly vector of disease expands its territory, it is clear that pesticide-intensive approaches are poorly equipped to cope with the threat as insect resistance to chemical controls steadily grows.  Native to South Asia, the Anopheles stephensi mosquito has been on a relentless journey, crossing continents from the Arabian Peninsula to East Africa and deeper into the African continent. The mosquito’s ability to quickly adapt to new environments, bolstered by shifting climate patterns, illustrates how global warming affects disease vectors. Matthew Thomas, PhD, emphasizes, “Anopheles stephensi has higher thermal tolerance and a capacity to transmit at higher temperatures than Anopheles gambiae [another malaria-spreading mosquito]. This is significant when considering climate change […]

(Beyond Pesticides, September 27, 2023) A study published in Pesticide Biochemistry and Physiology finds organophosphate (OP), organochlorine (OC), and pyrethroid (PYR) pesticides have links to insulin resistance (IR) associated with metabolic disorders like diabetes, obesity, chronic kidney disease (CKD), and hypertension. Metabolic disorders are among the leading causes of morbidity and mortality, with over 11 percent (>37 million) of individuals in the U.S. having diabetes, and cases are growing by millions annually. Additionally, there is a rise in metabolic disorders among young people. Studies even find low levels of pesticide exposure during pregnancy or childhood cause adverse health effects, including metabolic disorders tied to gut microbiome disruption (dysbiosis). With increasing rates of diabetes and obesity, the two most prominent metabolic diseases in the study, cases among the global population, studies like these highlight the importance of evaluating how chemical contaminants deregulate normal bodily function through metabolic changes.  To investigate the association between pesticide exposure and insulin-related metabolic disorders in humans, researchers searched the PubMed database for articles, performing a systematic review. The study notes, “IR is defined as a pathological state in which a higher-than-normal level of insulin is required to produce the optimal response in cells.” The search generated 4,051 articles related to the topic. However, after excluding duplicates and […]