Archive for the 'Disease/Health Effects' Category
23
May
(Beyond Pesticides, May 23-26, 2025) This Memorial Day, while honoring and mourning the U.S. military personnel who have died serving in the United States Armed Forces, Beyond Pesticides recognizes those who are still fighting the long-term impacts of exposure to toxic chemicals as a result of their use in warfare. A recent review in the Open Journal of Soil Science acts as a reminder of the effects that span multiple generations to both the environment and human health following the use of pesticides. The review analyzes the history and impacts of herbicide use during the Vietnam War, as well as emphasizes the importance and relevance for current and future generations. As the authors state, âThe United States (U.S.) and other countries, including Russia and Ukraine, need to learn the historical lessons from the U.S. use of herbicides, containing dioxin TCDD and/or arsenic (As), as chemical weapons during the Vietnam War.â As previously reported by Beyond Pesticides, public attention generally focuses on the ârainbow herbicides,â particularly Agent Orange, used during the Vietnam War; meanwhile, it is the dioxin TCDD (2,3,7,8 tetrachlorodibenzodioxin), a byproduct of Agent Orangeâs manufacturing process, that has caused the most lasting damage within the country. While the breakdown […]
Posted in 2,4-D, Agent Orange, air pollution, arsenic, Cancer, dioxin, DNA Damage, Drinking Water, Gulf War Syndrome, Holidays, multi-generational effects, Occupational Health, Pesticide Mixtures, Reproductive Health, TCDD | No Comments »
22
May
(Beyond Pesticides, May 22, 2025) A medical study published in the Journal of the American Medical Association (JAMA) finds that âliving within 1 mile of a golf course was associated with 126% increased odds of developing PD [Parkinsonâs Disease] compared with individuals living more than 6 miles away from a golf course.â While organic land management offers a simple solution, current pesticide restrictions do not address chronic neurological diseases such as Parkinsonâs Disease, which are linked to pesticide exposure. It has become increasingly clear that viable and cost-effective land management practices, including for golf course management, are critical to the protection of community health. Yet, the federal regulatory agencies, including the U.S. Environmental Protection Agency (EPA) and U.S. Food and Drug Administration (FDA), do not conduct an alternative practices assessment as part of their review process to determine whether the risks are âreasonableâ (statutory language) or the risk assessments accept an unnecessary hazard. The complexity of pesticide exposure, which includes mixtures of multiple chemicals and undisclosed hazardous âinertâ ingredients, raises broad questions about the threats to public health as well as biodiversity. See a recent Action of the Week, FDA Must Establish Tolerances for Pesticides Used in Mixtures, to see […]
Posted in 2,4-D, Chemical Mixtures, Chemicals, Chlorpyrifos, Disease/Health Effects, Drift, Golf, Paraquat, Parkinson's, Pesticide Drift, Uncategorized | No Comments »
16
May
(Beyond Pesticides, May 16, 2025) A Chinese study reports for the first time an association between gestational anemia (GA), pesticide exposure, and the potentially protective effects of gut microbes. While the report is a preprint and has not yet been peer reviewed, it establishes important connections eminently worthy of deeper investigation and suggests that the balance of gut microbes may be a highly effective way to reduce or prevent GA. This is a prospective study of women enrolled in 2017 and 2018 in the Mother and Child Microbiome Cohort, ongoing at a Nanjing hospital. The 731 women were over 18, without diabetes or gestational hypertension (which can affect gestational anemia). The researchers collected blood samples to analyze red blood cell count (RBC), hemoglobin (Hb), and levels of pesticides. They analyzed stool samples for gut bacteria composition. GA is extremely common. Pregnancy increases maternal blood volume by up to 50 percent, which produces obvious challenges to the mother. There is a strong gradient between the developing and developed countries: According to the World Health Organization, 35.5 percent of pregnant women globally had anemia in 2023. In Mali, 62.1 percent suffered from it. In the United States, about ten percent did. The […]
Posted in Atrazine, Chlorpyrifos, clomazone, gestational anemia, Microbiome, pyrimethanil, Uncategorized | No Comments »
13
May
(Beyond Pesticides, May 13, 2025) A study in Environmental Pollution examines ecological and health risks in farmland soil with pesticide contamination. âAlthough agricultural soil pesticide residues have long threatened the environment, a relatively complete system for evaluating their health and ecological risks has not yet been developed,â the authors state. In addressing this research gap, the study finds that âmore than ten pesticides were detected in 98.62% of the soil samples, which changed the soil environmentâ and threatens the health of the soil microbiome. The authors continue, âThis study investigated the correlation between pesticide residue risks and soil ecological security and human health, revealed the response characteristics of soil microbial communities under pesticide stress, and identified microbes strongly related to pesticide ecological risks.â Pesticides, as the authors emphasize, âinevitably pollute agricultural soil, affect the ecological environment, and pose a threat to human health.â (See studies here, here, and here.) With this in mind, they assess 50 selected pesticides in 145 soil samples from agricultural land in Zhejiang Province, China and calculate the associated risks to ecosystems and public health. In describing the importance of this research, the authors explain: âPesticides are prone to leakage and drift in environmental media, turning […]
Posted in Agriculture, Bifenthrin, Biodiversity, Cancer, Chlorpyrifos, Ecosystem Services, Imidacloprid, indoxacarb, Microbiome, Pesticide Mixtures, soil health | No Comments »
08
May
(Beyond Pesticides, May 8, 2025) A study, published in Environmental Pollutants and Bioavailability, assesses the impacts on Nile tilapia (Oreochromis niloticus) with subacute and chronic exposure to thiamethoxam, a neonicotinoid insecticide, and finds genotoxicity, oxidative stress, and changes in tissue structure, among other threats to organ function and overall fish health. âThe study focused on biochemical markers, genetic damage, pesticide residue levels in fish flesh, and histopathological changes in fish exposed to different concentrations of thiamethoxam,â the authors state. The threats do not end there; human health is also at risk from the consumption of these contaminated fish. âUnfortunately, neonicotinoids, rapidly washed into surface water from agricultural areas, pose a significant threat to environmental water quality and can harm non-target species, particularly aquatic organisms,â the researchers state. The accumulation of these chemicals leads to âultimately harming both aquatic ecosystems and human health,â they say. In particular, the study highlights that prolonged exposure to high doses of thiamethoxam can cause âsignificant negative effects on fish health,â the authors note. They continue: âThis exposure led to increased levels of urea and ALT [alanine aminotransferase] in the blood, indicating potential damage to the kidneys and liver. Additionally, thiamethoxam caused oxidative stress, as evidenced […]
Posted in Aquatic Organisms, fish, Kidney failure, Liver Damage, neonicotinoids, Oxidative Stress, Pesticide Residues, Thiamethoxam, Water | No Comments »
07
May
(Beyond Pesticides, May 7, 2025) Researchers at the University of Caxias do Sul (Brazil) identify 29 peer-reviewed scientific studies with statistically significant findings that tie pesticide use to cancer diagnoses. The literature review is published in SaĂşde Debate. This collection of clinical trials, as well as epidemiologic, case-control, and experimental studiesâfrom the United States, Brazil, India, France, Egypt, Columbia, Ecuador, Mexico, Italy, and Spainâadd to the hundreds of peer-reviewed independent analyses connecting synthetic chemical dependency in food production and land management with mounting public health concerns. Advocates continue to call for holistic solutions that move away from toxic inputs that disproportionately harm the communities responsible for the food on dinner tables, and instead cultivate microbial diversity in soil, rather than prophylactically spray for the sake of pest control. Beyond Pesticides values the importance of scientific integrity and open access to data to inform decision makers on how to adopt healthier practices for their communities. Reliable information for good governance is critical, which is a driving factor in the ongoing compilation of thousands of peer-reviewed literature compiled and curated in the Pesticide-Induced Disease Database and Gateway on Pesticide Hazards and Safe Pest Management. Background and Methodology The main objective of this […]
Posted in 2,4-D, Cancer, Chemical Mixtures, Chemicals, Disease/Health Effects, Uncategorized | No Comments »
02
May
* This article was cross-posted with permission from the Ecological Landscape Alliance, which was originally published on April 30, 2025. A link will be shared once it is made available. (Beyond Pesticides, May 2, 2025) With the current existential health, biodiversity, and climate threats, organic land management is a bright spot for the sustainable future envisioned by Beyond Pesticides. Founded in 1981, Beyond Pesticides began tracking the science of pesticide hazards and questioning dependency on toxic, fossil fuel-based pesticides as unnecessary to achieving effective land management, both in agricultural and nonagricultural contexts. The organization, which grew out of a series of site visits and field hearings to document the limitations of labor standards necessary to protect farmworkers, was created to bring together environmentalists, public health practitioners, farmers, land managers, farmworkers, and consumers. Nearly a decade before its founding and less than 20 years after the publication of Silent Spring, many important laws governing clean air, water, food safety, and pesticides had been adopted. However, these statutesâ focus on mitigating risks of harm to health and the environment has fallen short, according to Beyond Pesticides. Instead, the organization pursues a precautionary approach that is codified in organic standards that grow out of […]
Posted in Alternatives/Organics, Biodiversity, Children, Climate, Climate Change, Disease/Health Effects, National Organic Standards Board/National Organic Program, Parks for a Sustainable Future, Uncategorized | No Comments »
29
Apr
(Beyond Pesticides, April 29, 2025) A study in Environment International finds pesticide-induced alterations in the gut microbiota of a farmland raptor species. In collecting blood and cloacal samples from Montaguâs harrier (Circus pygargus) nestlings, the authors âshed light on an overlooked collateral effect of pesticides, i.e., a general modification of gut bacterial assemblages,â which can lead to an imbalance of microorganisms (dysbiosis) and the promotion of potential pathogens, as well as negatively impact the health of birds of prey. âAdditionally, our findings support the ‘One Health‘ framework, stressing the interconnectedness of wildlife, ecosystem, and human health, particularly in pesticide-affected agricultural areas,â the researchers share. âThe gut microbiota is crucial for host health and can be impacted by various environmental disruptions, yet the effects of multiple pesticide exposures on farmland organismsâ microbiomes remain largely unexplored,â the authors state. In the study, they âassessed microbiota changes in a wild apex predator exposed to multiple pesticides in agricultural landscapes,â which âprovides evidence of pesticide impacts on wildlife gut microbiota, highlighting links between pesticide exposure and changes in microbiota composition,â the researchers note. The Montaguâs harrier, as an apex predator, serves as a âbio-sentinelâ or bioindicator species for assessing ecosystem health. âAs top-level predators […]
Posted in Acetochlor, Alternatives/Organics, Biodiversity, Birds, Chlorpyrifos, Gut Dysbiosis, Microbiome, Pesticide Mixtures, Quinoxyfen, Wildlife/Endangered Sp. | No Comments »
25
Apr
(Beyond Pesticides, April 25, 2025) A novel study in Chemosphere finds impacts on male fertility in a bee species (Osmia bicornis) with exposure to sulfoxaflor, a systemic sulfoximine insecticide with similar mechanisms to neonicotinoids. âFor the first time, we demonstrate that short-term chronic, field-realistic exposure to a common pesticide reduced pre-copulatory display (36%) and sounds (27%) [courtship behaviors], increased the number of copulations (+110%) and the mating duration (+166%), while finally reducing sperm quantity (25%) and mating success (43%),â the researchers report. They continue, âOur research raises considerable concern on the impact of field-realistic, low sublethal pesticide levels on the fertility and reproductive success of pollinators.â Mating behaviors and the ability to successfully reproduce determines the survival of species. As the authors state: âMating disorders may therefore contribute to the recent decline in insect and pollinators’ health worldwide. While the impact of pesticides on pollinators is widely considered as a driving factor for reducing pollinators’ health, their effect on mating behaviour and male fertility remains widely overlooked.â The red mason bee (O. bicornis) can âprovide essential pollination service for both crops and wild plants sustaining food production and biodiversity while serving as a bioindicator of environmental health.â The abundance and […]
Posted in Beneficials, Biodiversity, Clothianidin, fenbuconazole, men's health, Oxidative Stress, Pesticide Mixtures, Pollinators, Reproductive Health, Sulfoxaflor, Thiamethoxam | No Comments »
23
Apr
(Beyond Pesticides, April 23, 2025) Recent reviews of scientific literature, in both Chemosphere and Reports in Public Health, associate Parkinsonâs disease (PD), the second most prevalent neurodegenerative disease globally, with pesticide exposure. âGiven the pervasive nature of pesticide residues in everyday food consumption and inadequate monitoring of their long-term toxicological impacts, the role of pesticide exposure as a modifiable risk factor for neurological disorders, including PD, warrants urgent attention,â the researchers state in the article in Chemosphere. In describing the history of Parkinsonâs and previous research, the authors in Reports in Public Health note that while PD etiology is not fully understood, it is a multifactorial disease. âHereditary factors are present in approximately 10% of diagnosed cases of Parkinsonâs disease, presenting early onset; while the other 90% of cases are categorized as idiopathic or sporadic Parkinsonâs disease, occurring in older individuals and may be associated with exposure to environmental agents,â the researchers say. This disease, first described by English physician James Parkinson, M.D. in 1817, involves neurochemical changes that present as âthe appearance of cardinal motor symptoms, such as bradykinesia, rigidity, postural instability, and rest tremor, which are essential for the clinical diagnosis of the disease,â the researchers note. The […]
Posted in 2,4-D, Atrazine, behavioral and cognitive effects, Brain Effects, Chlorpyrifos, cypermethrin, Dichlorvos, Dieldrin, Environmental Protection Agency (EPA), Glyphosate, Malathion, mancozeb, Maneb, Nervous System Effects, Oxidative Stress, Paraquat, Parkinson's, Pesticide Mixtures, Rotenone | No Comments »
18
Apr
(Beyond Pesticides, April 18, 2025) A recent study published in Foods assesses the ability of the fungicide azoxystrobin (AZX) and naturally occurring toxins produced by certain fungi, known as mycotoxins, to display effects of cytotoxicity (cell damage). These effects were evaluated using three common mycotoxins found in food, including ochratoxin A (OTA), deoxynivalenol (DON), and T-2 toxin as mixtures with AZX within human hepatocarcinoma (HepG2) cell cultures. In analyzing combinations of these compounds at sublethal concentrations, the authors find modified toxicological behavior and synergistic effects that highlight the complexities of chemical mixtures, and potential threats to liver health through dietary exposure to both toxicants and toxins, that are not adequately regulated for their interactions. While fungicides, like azoxystrobin, are intended to prevent or control fungal diseases, resistance to these pesticides can increase the presence of fungi, and subsequent mycotoxins, on crops. This scenario allows for co-exposure of fungicides and mycotoxins within food products that present a risk to consumers. These chemicals can threaten human health individually, as the researchers confirm in their study, but present a greater threat in combination. The mixture of AZX with all three mycotoxins exhibits the highest toxicity, with synergistic effects at all tested concentration levels. […]
Posted in Agriculture, Azoxystrobin, Chemical Mixtures, European Union, Fungicides, Liver Damage, National Organic Standards Board/National Organic Program, NOSB National Organic Standards Board, Oxidative Stress, Pesticide Residues, synergistic effects | No Comments »
17
Apr
(Beyond Pesticides, April 17, 2025) A literature review in Reproductive Sciences finds glyphosate (GLY) and glyphosate-based herbicides (GBH) impact womenâs reproductive health, adding to the long list of documented harm from this widely used weed killer. The authors note, âConsidering the widespread use of GLY, the controversy regarding its endocrine-disrupting potential and reproductive toxicity, and the innumerable lawsuits filed against Bayer and Monsanto by consumers for morbidities related to Roundup™ exposure, the purpose of this review is to summarize the current literature on the potential adverse effects of GLY and GBHs on the female reproductive tract and discuss possible clinical implications on reproductive health outcomes, including polycystic ovarian syndrome (PCOS), endometriosis, and female fertility.â Glyphosate and aminomethylphosphonic acid (AMPA), the primary metabolite (breakdown product) of GLY, are found throughout the environment in soil and water, as well as in samples of blood, urine, seminal plasma, and breast milk. Studies have detected residues in farmworkers, as well as “in the urine of 60â80% of the general public in the USA, including pregnant women and children.â (See studies here, here, and here.) The ubiquitous use of GLY and GBH, and subsequent persistence, threatens the health and well-being of all. Previous studies have […]
Posted in Agriculture, aminomethylphosphonic acid (AMPA), Bayer, DNA Damage, Endocrine Disruption, endometriosis, Glyphosate, Herbicides, Infertility, Monsanto, Oxidative Stress, Reproductive Health, Women's Health | No Comments »
08
Apr
(Beyond Pesticides, April 8, 2025) A comprehensive literature review in Environment & Health analyzes evidence from human biomonitoring, epidemiological studies, and toxicological studies that link adverse effects on womenâs reproductive health, specifically impacting the ovary, to pesticide exposure. In examining the scientific literature, consisting of over 200 studies performed in the last 25 years, the authors find pesticide exposure threatens womenâs health through ovarian dysfunction. âEpidemiological studies have shown that pesticide exposures are associated with early/delayed menarche [first occurrence of menstruation], menstrual cycle disorders, early menopause, long time to pregnancy, polycystic ovary syndrome, primary ovarian insufficiency, infertility, and implantation failure in women,â the researchers state. They continue, âBoth in vivo [in animals] and in vitro [in cells] studies have shown that exposure to pesticides disrupts the estrous cycle, reduces the follicle pool, alters hormone levels, and impairs oocyte [egg] maturation.â These reproductive implications are noted with many different classes of pesticides, such as insecticides, including organochlorine pesticides (OCPs), organophosphates (OPs), pyrethroids, and neonicotinoids, as well as herbicides and fungicides. The authors, however, comment on present research gaps: âMuch of the available epidemiological evidence focuses on legacy insecticides, such as OCPs, and a subset of insecticides that are still in use […]
Posted in acetamiprid, Atrazine, Bifenthrin, Chlorpyrifos, cypermethrin, DDT, Deltamethrin, Diazinon, fenvalerate, Glyphosate, Imidacloprid, Infertility, lambda-cyhalothrin, Lindane, Malathion, mancozeb, Oxidative Stress, Permethrin, Reproductive Health, Thiamethoxam, vinclozolin, Women's Health | No Comments »
03
Apr
(Beyond Pesticides, April 3, 2025) As highlighted by Beyond Pesticides in recent comments to the U.S. Environmental Protection Agency (EPA), chlorpyrifos (CPF) has been under scrutiny for decades due to associated adverse health effects, noted particularly in the extensive and consistent scientific evidence of neurotoxic dangers to childrenâs health. The latest research on CPF, published in Environmental Toxicology and Genes & Diseases, reveals additional threats to the immune system and male reproduction that are not captured in current EPA risk assessments of chlorpyrifos and raises serious health questions, given that residues are found throughout the food supply. CPF, a widely used organophosphate insecticide in agriculture, is a cholinesterase inhibitor that binds irreversibly to the active site of an essential enzyme for normal nerve impulse transmission, acetylcholine esterase (AChE), inactivating the enzyme. Many insecticides, including organophosphates and carbamates, target AChE, causing them to be highly toxic to both insects and mammals that have this enzyme as a crucial part of their nervous systems. The history of chlorpyrifos exemplifies the failure of pesticide law and policy, as this chemical, among many others, not only has direct adverse health effects but is contributing to the climate crisis, biodiversity collapse, and disproportionate levels of […]
Posted in Agriculture, Cancer, Chlorpyrifos, Developmental Disorders, DNA Damage, Environmental Protection Agency (EPA), Immunotoxicity, Infertility, men's health, Oxidative Stress, Reproductive Health | No Comments »
02
Apr
(Beyond Pesticides, April 2, 2025) In examining prenatal residential proximity of documented pesticide spraying in California to the menstrual cycle characteristics of 273 Latina adolescents, researchers report in the American Journal of Epidemiology a positive association between exposure to the insecticide methomyl and heavy bleeding. Other pesticides appear to influence menstrual symptoms as well. âAdolescentsâ menstrual cycle characteristics can be âvital signsâ of health and impact quality of life,â the authors share. They continue, âTo our knowledge, this is the first study to examine the association between prenatal pesticide exposure and menstrual outcomes in adolescents of any demographic group.â Menstrual cycle characteristics, such as dysmenorrhea (painful or uncomfortable menstrual cramps), irregularity, and heavy menstrual bleeding, can also be indicators of underlying health conditions, including endometriosis, polycystic ovary syndrome (PCOS), thyroid dysfunction, and bleeding disorders. By associating the pesticide exposure of mothers during pregnancy to impacts on their children, the researchers highlight important health risks for women and young girls that are often disregarded. âThe prenatal period is a critical period of reproductive development that may be particularly sensitive to endocrine disruption,â the researchers share. As previously reported by Beyond Pesticides, endocrine-disrupting chemicals are any synthetic or natural compounds that hinder […]
Posted in Acephate, California, Children, Chlorpyrifos, Diazinon, Dimethoate, Endocrine Disruption, endometriosis, Environmental Protection Agency (EPA), Glyphosate, Imidacloprid, Malathion, mancozeb, Maneb, Methomyl, Oxidative Stress, Permethrin, Reproductive Health, Women's Health | No Comments »
01
Apr
(Beyond Pesticides, April 1, 2025) With the second largest award of nearly $2.1 billion (see reporting on largest), a jury in Georgia state court on March 21 found the pesticide manufacturer Bayer/Monsanto guilty of causing a manâs non-Hodgkin’s lymphoma after use of the companyâs glyphosate-based weedkiller RoundupTM product. The juryâs award includes $65 million in compensatory and $2 billion in punitive damages, as reported by the Associated Press and Courtroom View Network. This verdict in Barnes v. Monsanto (2025) comes amid a concerted effort by Bayer and other chemical and agribusiness groups to take away the main legal argument, âfailure-to-warn,â for the type of litigation that pesticide exposure victims have commonly used to hold companies accountable. This is happening as Governor Brian Kemp of Georgia considers signing into state law a pesticide immunity bill that will prevent future litigation like this in the state. In a deregulatory environment, the courts and state governments are viewed as critical backstops, given the dismantling of the U.S. Environmental Protection Agencyâs (EPA) regulatory apparatus and extremely limited Congressional oversight. History of Litigation Bayer has lost almost all of the cases filed against it for compensation and punitive damages associated with the plaintiffsâ charge that […]
Posted in Bayer, Failure to Warn, Georgia, Glyphosate, Litigation, Monsanto, non-Hodgkin's Lymphoma, Preemption, Uncategorized | No Comments »
27
Mar
(Beyond Pesticides, March 27, 2025) In Ecotoxicology, results of a study on Nile tilapia (Oreochromis niloticus) exposed to florpyrauxifen-benzyl (FPX) suggest the new herbicide causes oxidative stress (imbalances affecting the bodyâs detoxification abilities that lead to cell and tissue damage), with specific genotoxic (damage to genetic material) and hepatotoxic (damage to the liver) effects on nontarget species. The authors state: âAccording to the available literature, no data exist on the toxicity of FPX in fish. Therefore, this study aims to investigate, for the first time, the potential toxicity and associated mechanistic effects of the pyridine-carboxylic acid herbicide (FPX) on the non-target species, Nile tilapia.â According to the Wisconsin Department of Natural Resources, âFlorpyrauxifen-benzyl is a systemic herbicide (i.e., it moves throughout the plant tissue). It is a WSSA Group 4 herbicide, meaning that the mechanism of action is by mimicking the plant growth hormone auxin and causing excessive elongation of plant cells, ultimately killing the plant.â The researchers, from Menoufia University, the Agricultural Research Center, and Cairo University in Egypt, focus on FPX as it is the active ingredient in Divixton 2.5% EC, a newly released herbicide used in rice fields and applied directly to freshwater aquatic bodies for emergent […]
Posted in Aquatic Organisms, Biodiversity, florpyrauxifen-benzyl, Herbicides, Liver Damage, Oxidative Stress, Water | No Comments »
25
Mar
(Beyond Pesticides, March 25, 2025) An editorial in Expert Review of Cardiovascular Therapy finds that triazole fungicides pose a significant risk of cardiotoxicity with âgrowing concerns regarding their safety for human health, especially in long-term exposure,â the authors share. After analyzing the known mechanisms of cardiotoxicity of triazole pesticides in mammals, they conclude that âthe most effective approach to mitigating triazole-induced cardiotoxicity lies in prevention.â Triazoles, a class of fungicides, target fungi by inhibiting the biosynthesis of ergosterol, an essential component of their cell membranes. As the researchers share, âCompounds such as tebuconazole, propiconazole, and difenoconazole are among the most used triazoles in agriculture.â Triazoles are utilized as antifungal medications, despite the rise of resistant infections, in addition to their use as systemic pesticides on many fruit and vegetable crops, including grapes, wheat, corn, and soybeans.  As Beyond Pesticidesâ previous coverage indicates, many triazole fungicides in the U.S. are registered for use despite evidence of endocrine disruption established over a decade ago in a U.S. Geological Survey report. These pesticides exhibit common mechanisms of toxicity often disregarded in U.S. Environmental Protection Agency (EPA) risk assessments, with a multitude of studies showcasing the myriads of health threats that the agency does […]
Posted in Cardiovascular Disease, difenoconazole, Endocrine Disruption, Fungicides, Oxidative Stress, Propiconazole, tebuconazole | No Comments »
24
Mar
(Beyond Pesticides, March 24, 2025) In establishing the Make America Healthy Again Commission in February, the President tapped Secretary of the U.S. Department of Health and Human Services Robert F. Kennedy, Jr. to chair the interagency panel. The stated goal, as described in the founding proclamation, is âdrastically lowering chronic disease rates and ending childhood chronic disease.â The commission document states, âOverall, the global comparison data demonstrates that the health of Americans is on an alarming trajectory that requires immediate action.â In this context, on March 10, Secretary Kennedy directed Food and Drug Administration (FDA) Acting Commissioner Sara Brenner, MD to take steps to explore potential rulemaking to revise its Substances Generally Recognized as Safe (GRAS) Final Rule and related guidance to eliminate the self-affirmed GRAS pathwayâallowing the food and chemical industry to assign GRAS status to food ingredients without oversight. This âpathwayâ to allowing food additives has long been recognized as a loophole that allows unidentified and potentially harmful additives in food, including by the 2010 U.S. General Accountability Office (GAO) report, Food Safety: FDA Should Strengthen Its Oversight of Food Ingredients Determined to Be Generally Recognized as Safety. Beyond Pesticides launched an effort this week to tell FDA to eliminate the self-affirmed […]
Posted in Children, Department of Health and Human Services, Disease/Health Effects, Food and Drug Administration (FDA), Take Action, Uncategorized | 2 Comments »
17
Mar
(Beyond Pesticides, March 17, 2025) When Secretary of Health and Human Services Robert F. Kennedy, Jr. announced last week that he is directing the U.S. Food and Drug Administration (FDA) to explore rulemaking to review substances in food affirmed by the food companies to be Generally Recognized as Safe (GRAS), he said he is âcommitted to promoting radical transparency to make sure all Americans know what is in their food.â The issue of independent review of the food industryâs GRAS declarations has long been the subject of critiques raising public health concerns. As this issue emerged, on another food safety issue, Beyond Pesticides is asking FDA to use its broad authority under the Federal Food, Drug, and Cosmetic Act to âensur(e) that human foods and animal feeds are safeâ from residues of pesticide mixtures, in light of new troubling scientific data. Under various memoranda of understanding between FDA, the U.S. Environmental Protection Agency (EPA), and the U.S. Department of Agriculture (USDA) going back decades, FDA could consult with EPA on food safety issues ignored by the agency, including  recent data published in Pesticide Biochemistry and Physiology, which âsuggest that combined [pesticide] exposure may further amplify the toxicity and compromise the intestinal […]
Posted in Abamectin, Carbendazim, Chlorpyrifos, Environmental Protection Agency (EPA), fluazinam, Food and Drug Administration (FDA), Generally Recognized As Safe (GRAS), Imidacloprid, Intestinal Damage, NOSB National Organic Standards Board, spirodiclofen, Take Action, Uncategorized, US Department of Agriculture (USDA) | No Comments »
13
Mar
(Beyond Pesticides, March 13, 2025) Study results published in Pesticide Biochemistry and Physiology âsuggest that combined [pesticide] exposure may further amplify the toxicity and compromise the intestinal barrier.â The researchers studied the toxic effects of the insecticides abamectin and spirodiclofen, as well as the fungicide fluazinam, individually and in combination. In exposing mice and Caco-2 cells to these pesticides, the results show the disruption of intestinal functions and highlight the need to assess potential synergistic effects of pesticide mixtures as a part of the regulatory review process. Effects on the intestinal barriers of mice represent a threat to âthe first line of defense against the external environment,â the researchers say. The intestinal mucosal epithelial structure plays an important role in preventing harmful substances from entering the intestines and causing damage to cells. [Caco-2 cells represent a human cell line, derived from a colon cancer patientâs tissue, and mimic the small intestine. These cells are vital in research as a model of the intestinal epithelial barrier.] âCurrently, most studies investigating the effects of pesticide residues on the barrier function of Caco-2 cells concentrate on the exposure to a single residue, while the potential toxic effects arising from the concurrent presence of multiple pesticide […]
Posted in Abamectin, Chemical Mixtures, Environmental Protection Agency (EPA), fluazinam, Intestinal Damage, Pesticide Mixtures, spirodiclofen, synergistic effects | No Comments »
11
Mar
(Beyond Pesticides, March 11, 2025) A study in Toxics analyzes ipconazole, a triazole fungicide often used as a coating on treated seeds and as a foliar treatment on the leaves of plants. âTriazole pesticides are widely used throughout the world, but their abuse causes toxic effects in non-targeted organisms,â the researchers state. In the current study, unintended reproductive effects are noted in male sheep (ram) and pigs (also known as porcine or swine). This research focuses on the impact of ipconazole exposure on spermatozoa (sperm) in two mammal species and finds spermiotoxicity through significantly reduced sperm viability, as well as alterations in enzyme and gene expression related to fertility. âTo our knowledge, this is the first study to evaluate the cytotoxic effect of the triazole ipconazole on mammalian spermatozoa,â the authors share. This analysis utilizes semen samples from the Reproductive Biotechnology Laboratory of the Major National University of San Marcos in Lima, Peru, the university where six of the nine researchers are Faculty of Veterinary Medicine.  âThe sperm were exposed to ipconazole concentrations of 1, 5, 10, 50 and 100 ÂľM, and to a control without ipconazole,â they say. Similar concentrations have been used in previous cytotoxicity studies with ipconazole. […]
Posted in difenoconazole, Endocrine Disruption, Epigenetic, Infertility, Ipconazole, Livestock, men's health, Oxidative Stress, Peru, Reproductive Health, tebuconazole | No Comments »
10
Mar
(Beyond Pesticides, March 10, 2025) Following International Womenâs Day, celebrated on March 8, 2025, the poignant findings on women, gender, and hazardous substances in a United Nations report raise critical issues of concern and cause for urgent action to phase out petrochemicals. The Report of the Special Rapporteur on the implications for human rights of the environmentally sound management and disposal of hazardous substances and wastes, by Marcos Orellana, was delivered to the 79th Session of the United Nations General Assembly in July 2024. Excerpts from the report follow: âWomen make up roughly 60 to 70 per cent of the agricultural labour force in developing countries where pesticides and pesticide handling are especially poorly regulated. In Zambia, for example, two thirds of the labour force is engaged in agriculture, and 78 per cent are women farmers and peasants. Women there play a significant role in pesticide application, often without any or adequate personal protective equipment, especially during activities such as weeding, harvesting, and washing pesticide-laden clothes.â âIn higher-income countries, women who do agricultural work are often poor and/or migrants; pesticides are one of many dimensions of marginalization and damage to their well-being. The European agriculture sector uses many seasonal and […]
Posted in Agriculture, Alternatives/Organics, Breast Cancer, Cancer, Endocrine Disruption, Environmental Justice, Environmental Protection Agency (EPA), Farmworkers, Take Action, Uncategorized | No Comments »