[X] CLOSEMAIN MENU

  • Archives

  • Categories

    • air pollution (9)
    • Announcements (611)
    • Antibiotic Resistance (47)
    • Antimicrobial (22)
    • Aquaculture (31)
    • Aquatic Organisms (43)
    • Artificial Intelligence (1)
    • Bats (18)
    • Beneficials (70)
    • biofertilizers (2)
    • Biofuels (6)
    • Biological Control (36)
    • Biomonitoring (40)
    • Biostimulants (1)
    • Birds (30)
    • btomsfiolone (1)
    • Bug Bombs (2)
    • Cannabis (31)
    • Centers for Disease Control and Prevention (CDC) (13)
    • Chemical Mixtures (19)
    • Children (137)
    • Children/Schools (243)
    • cicadas (1)
    • Climate (44)
    • Climate Change (108)
    • Clover (1)
    • compost (8)
    • Congress (28)
    • contamination (166)
    • deethylatrazine (1)
    • diamides (1)
    • Disinfectants & Sanitizers (19)
    • Drift (22)
    • Drinking Water (22)
    • Ecosystem Services (36)
    • Emergency Exemption (3)
    • Environmental Justice (182)
    • Environmental Protection Agency (EPA) (603)
    • Events (91)
    • Farm Bill (28)
    • Farmworkers (216)
    • Forestry (6)
    • Fracking (4)
    • Fungal Resistance (8)
    • Generally Recognized As Safe (GRAS) (1)
    • Goats (2)
    • Golf (16)
    • Greenhouse (1)
    • Groundwater (19)
    • Health care (32)
    • Herbicides (56)
    • Holidays (45)
    • Household Use (9)
    • Indigenous People (8)
    • Indoor Air Quality (7)
    • Infectious Disease (4)
    • Integrated and Organic Pest Management (80)
    • Invasive Species (35)
    • Label Claims (51)
    • Lawns/Landscapes (257)
    • Litigation (356)
    • Livestock (13)
    • men’s health (9)
    • metabolic syndrome (3)
    • Metabolites (11)
    • Mexico (1)
    • Microbiata (26)
    • Microbiome (37)
    • molluscicide (1)
    • Nanosilver (2)
    • Nanotechnology (54)
    • National Politics (389)
    • Native Americans (4)
    • Occupational Health (22)
    • Oceans (12)
    • Office of Inspector General (5)
    • perennial crops (1)
    • Pesticide Drift (172)
    • Pesticide Efficacy (13)
    • Pesticide Mixtures (25)
    • Pesticide Residues (200)
    • Pets (37)
    • Plant Incorporated Protectants (3)
    • Plastic (13)
    • Poisoning (22)
    • President-elect Transition (3)
    • Reflection (3)
    • Repellent (4)
    • Resistance (128)
    • Rights-of-Way (1)
    • Rodenticide (36)
    • Seasonal (5)
    • Seeds (8)
    • soil health (42)
    • Superfund (5)
    • synergistic effects (33)
    • Synthetic Pyrethroids (18)
    • Synthetic Turf (3)
    • Take Action (629)
    • Textile/Apparel/Fashion Industry (1)
    • Toxic Waste (12)
    • U.S. Supreme Court (5)
    • Volatile Organic Compounds (2)
    • Women’s Health (37)
    • Wood Preservatives (36)
    • World Health Organization (12)
    • Year in Review (3)
  • Most Viewed Posts

Daily News Blog

Archive for the 'Disease/Health Effects' Category


23
May

On Memorial Day, Remember the Lives Lost and Those Still Fighting the Effects of Military Pesticide Use

(Beyond Pesticides, May 23-26, 2025) This Memorial Day, while honoring and mourning the U.S. military personnel who have died serving in the United States Armed Forces, Beyond Pesticides recognizes those who are still fighting the long-term impacts of exposure to toxic chemicals as a result of their use in warfare. A recent review in the Open Journal of Soil Science acts as a reminder of the effects that span multiple generations to both the environment and human health following the use of pesticides. The review analyzes the history and impacts of herbicide use during the Vietnam War, as well as emphasizes the importance and relevance for current and future generations. As the authors state, “The United States (U.S.) and other countries, including Russia and Ukraine, need to learn the historical lessons from the U.S. use of herbicides, containing dioxin TCDD and/or arsenic (As), as chemical weapons during the Vietnam War.” As previously reported by Beyond Pesticides, public attention generally focuses on the “rainbow herbicides,” particularly Agent Orange, used during the Vietnam War; meanwhile, it is the dioxin TCDD (2,3,7,8 tetrachlorodibenzodioxin), a byproduct of Agent Orange’s manufacturing process, that has caused the most lasting damage within the country. While the breakdown […]

Share

22
May

Golf Courses Linked to Parkinson’s Disease and Pesticide Use

(Beyond Pesticides, May 22, 2025) A medical study published in the Journal of the American Medical Association (JAMA) finds that “living within 1 mile of a golf course was associated with 126% increased odds of developing PD [Parkinson’s Disease] compared with individuals living more than 6 miles away from a golf course.” While organic land management offers a simple solution, current pesticide restrictions do not address chronic neurological diseases such as Parkinson’s Disease, which are linked to pesticide exposure. It has become increasingly clear that viable and cost-effective land management practices, including for golf course management, are critical to the protection of community health. Yet, the federal regulatory agencies, including the U.S. Environmental Protection Agency (EPA) and U.S. Food and Drug Administration (FDA), do not conduct an alternative practices assessment as part of their review process to determine whether the risks are “reasonable” (statutory language) or the risk assessments accept an unnecessary hazard. The complexity of pesticide exposure, which includes mixtures of multiple chemicals and undisclosed hazardous “inert” ingredients, raises broad questions about the threats to public health as well as biodiversity. See a recent Action of the Week, FDA Must Establish Tolerances for Pesticides Used in Mixtures, to see […]

Share

16
May

Pesticide Exposure-Induced Gestational Anemia Mitigated by Maternal Gut Microbiota

(Beyond Pesticides, May 16, 2025) A Chinese study reports for the first time an association between gestational anemia (GA), pesticide exposure, and the potentially protective effects of gut microbes. While the report is a preprint and has not yet been peer reviewed, it establishes important connections eminently worthy of deeper investigation and suggests that the balance of gut microbes may be a highly effective way to reduce or prevent GA. This is a prospective study of women enrolled in 2017 and 2018 in the Mother and Child Microbiome Cohort, ongoing at a Nanjing hospital. The 731 women were over 18, without diabetes or gestational hypertension (which can affect gestational anemia). The researchers collected blood samples to analyze red blood cell count (RBC), hemoglobin (Hb), and levels of pesticides. They analyzed stool samples for gut bacteria composition. GA is extremely common. Pregnancy increases maternal blood volume by up to 50 percent, which produces obvious challenges to the mother. There is a strong gradient between the developing and developed countries: According to the World Health Organization, 35.5 percent of pregnant women globally had anemia in 2023. In Mali, 62.1 percent suffered from it. In the United States, about ten percent did. The […]

Share

13
May

Adding to Wide Body of Science, Study Finds Pesticide Residues Threaten Health of Soil Microbiome

(Beyond Pesticides, May 13, 2025) A study in Environmental Pollution examines ecological and health risks in farmland soil with pesticide contamination. “Although agricultural soil pesticide residues have long threatened the environment, a relatively complete system for evaluating their health and ecological risks has not yet been developed,” the authors state. In addressing this research gap, the study finds that “more than ten pesticides were detected in 98.62% of the soil samples, which changed the soil environment” and threatens the health of the soil microbiome. The authors continue, “This study investigated the correlation between pesticide residue risks and soil ecological security and human health, revealed the response characteristics of soil microbial communities under pesticide stress, and identified microbes strongly related to pesticide ecological risks.” Pesticides, as the authors emphasize, “inevitably pollute agricultural soil, affect the ecological environment, and pose a threat to human health.” (See studies here, here, and here.) With this in mind, they assess 50 selected pesticides in 145 soil samples from agricultural land in Zhejiang Province, China and calculate the associated risks to ecosystems and public health. In describing the importance of this research, the authors explain: “Pesticides are prone to leakage and drift in environmental media, turning […]

Share

08
May

Neonicotinoid Exposure Threatens Fish Health, Highlighting Cascading Effects to Humans as Consumers

(Beyond Pesticides, May 8, 2025) A study, published in Environmental Pollutants and Bioavailability, assesses the impacts on Nile tilapia (Oreochromis niloticus) with subacute and chronic exposure to thiamethoxam, a neonicotinoid insecticide, and finds genotoxicity, oxidative stress, and changes in tissue structure, among other threats to organ function and overall fish health. “The study focused on biochemical markers, genetic damage, pesticide residue levels in fish flesh, and histopathological changes in fish exposed to different concentrations of thiamethoxam,” the authors state. The threats do not end there; human health is also at risk from the consumption of these contaminated fish. “Unfortunately, neonicotinoids, rapidly washed into surface water from agricultural areas, pose a significant threat to environmental water quality and can harm non-target species, particularly aquatic organisms,” the researchers state. The accumulation of these chemicals leads to “ultimately harming both aquatic ecosystems and human health,” they say. In particular, the study highlights that prolonged exposure to high doses of thiamethoxam can cause “significant negative effects on fish health,” the authors note. They continue: “This exposure led to increased levels of urea and ALT [alanine aminotransferase] in the blood, indicating potential damage to the kidneys and liver. Additionally, thiamethoxam caused oxidative stress, as evidenced […]

Share

07
May

Farmers Face Elevated Cancer Risks Tied to Chemical Soup of Pesticide Exposure

(Beyond Pesticides, May 7, 2025) Researchers at the University of Caxias do Sul (Brazil) identify 29 peer-reviewed scientific studies with statistically significant findings that tie pesticide use to cancer diagnoses. The literature review is published in SaĂşde Debate. This collection of clinical trials, as well as epidemiologic, case-control, and experimental studies—from the United States, Brazil, India, France, Egypt, Columbia, Ecuador, Mexico, Italy, and Spain—add to the hundreds of peer-reviewed independent analyses connecting synthetic chemical dependency in food production and land management with mounting public health concerns. Advocates continue to call for holistic solutions that move away from toxic inputs that disproportionately harm the communities responsible for the food on dinner tables, and instead cultivate microbial diversity in soil, rather than prophylactically spray for the sake of pest control. Beyond Pesticides values the importance of scientific integrity and open access to data to inform decision makers on how to adopt healthier practices for their communities. Reliable information for good governance is critical, which is a driving factor in the ongoing compilation of thousands of peer-reviewed literature compiled and curated in the Pesticide-Induced Disease Database and Gateway on Pesticide Hazards and Safe Pest Management. Background and Methodology The main objective of this […]

Share

02
May

Commentary: Moving Beyond Pesticides Toward an Organic Future

* This article was cross-posted with permission from the Ecological Landscape Alliance, which was originally published on April 30, 2025. A link will be shared once it is made available. (Beyond Pesticides, May 2, 2025) With the current existential health, biodiversity, and climate threats, organic land management is a bright spot for the sustainable future envisioned by Beyond Pesticides. Founded in 1981, Beyond Pesticides began tracking the science of pesticide hazards and questioning dependency on toxic, fossil fuel-based pesticides as unnecessary to achieving effective land management, both in agricultural and nonagricultural contexts. The organization, which grew out of a series of site visits and field hearings to document the limitations of labor standards necessary to protect farmworkers, was created to bring together environmentalists, public health practitioners, farmers, land managers, farmworkers, and consumers.  Nearly a decade before its founding and less than 20 years after the publication of Silent Spring, many important laws governing clean air, water, food safety, and pesticides had been adopted. However, these statutes’ focus on mitigating risks of harm to health and the environment has fallen short, according to Beyond Pesticides. Instead, the organization pursues a precautionary approach that is codified in organic standards that grow out of […]

Share

29
Apr

Pesticides Linked to Altered Gut Microbiota in Farmland Bird of Prey, Raising Biodiversity Concerns

(Beyond Pesticides, April 29, 2025) A study in Environment International finds pesticide-induced alterations in the gut microbiota of a farmland raptor species. In collecting blood and cloacal samples from Montagu’s harrier (Circus pygargus) nestlings, the authors “shed light on an overlooked collateral effect of pesticides, i.e., a general modification of gut bacterial assemblages,” which can lead to an imbalance of microorganisms (dysbiosis) and the promotion of potential pathogens, as well as negatively impact the health of birds of prey. “Additionally, our findings support the ‘One Health‘ framework, stressing the interconnectedness of wildlife, ecosystem, and human health, particularly in pesticide-affected agricultural areas,” the researchers share. “The gut microbiota is crucial for host health and can be impacted by various environmental disruptions, yet the effects of multiple pesticide exposures on farmland organisms’ microbiomes remain largely unexplored,” the authors state. In the study, they “assessed microbiota changes in a wild apex predator exposed to multiple pesticides in agricultural landscapes,” which “provides evidence of pesticide impacts on wildlife gut microbiota, highlighting links between pesticide exposure and changes in microbiota composition,” the researchers note. The Montagu’s harrier, as an apex predator, serves as a ‘bio-sentinel’ or bioindicator species for assessing ecosystem health. “As top-level predators […]

Share

25
Apr

Male Fertility and Reproduction in Bee Species Threatened with Systemic Insecticide Exposure, Study Finds

(Beyond Pesticides, April 25, 2025) A novel study in Chemosphere finds impacts on male fertility in a bee species (Osmia bicornis) with exposure to sulfoxaflor, a systemic sulfoximine insecticide with similar mechanisms to neonicotinoids. “For the first time, we demonstrate that short-term chronic, field-realistic exposure to a common pesticide reduced pre-copulatory display (36%) and sounds (27%) [courtship behaviors], increased the number of copulations (+110%) and the mating duration (+166%), while finally reducing sperm quantity (25%) and mating success (43%),” the researchers report. They continue, “Our research raises considerable concern on the impact of field-realistic, low sublethal pesticide levels on the fertility and reproductive success of pollinators.” Mating behaviors and the ability to successfully reproduce determines the survival of species. As the authors state: “Mating disorders may therefore contribute to the recent decline in insect and pollinators’ health worldwide. While the impact of pesticides on pollinators is widely considered as a driving factor for reducing pollinators’ health, their effect on mating behaviour and male fertility remains widely overlooked.” The red mason bee (O. bicornis) can “provide essential pollination service for both crops and wild plants sustaining food production and biodiversity while serving as a bioindicator of environmental health.” The abundance and […]

Share

23
Apr

Literature Reviews Add to Wide Body of Science Connecting Pesticides to Parkinson’s Disease

(Beyond Pesticides, April 23, 2025) Recent reviews of scientific literature, in both Chemosphere and Reports in Public Health, associate Parkinson’s disease (PD), the second most prevalent neurodegenerative disease globally, with pesticide exposure. “Given the pervasive nature of pesticide residues in everyday food consumption and inadequate monitoring of their long-term toxicological impacts, the role of pesticide exposure as a modifiable risk factor for neurological disorders, including PD, warrants urgent attention,” the researchers state in the article in Chemosphere. In describing the history of Parkinson’s and previous research, the authors in Reports in Public Health note that while PD etiology is not fully understood, it is a multifactorial disease. “Hereditary factors are present in approximately 10% of diagnosed cases of Parkinson’s disease, presenting early onset; while the other 90% of cases are categorized as idiopathic or sporadic Parkinson’s disease, occurring in older individuals and may be associated with exposure to environmental agents,” the researchers say. This disease, first described by English physician James Parkinson, M.D. in 1817, involves neurochemical changes that present as “the appearance of cardinal motor symptoms, such as bradykinesia, rigidity, postural instability, and rest tremor, which are essential for the clinical diagnosis of the disease,” the researchers note. The […]

Share

18
Apr

Widely Used Fungicide Mixed with Natural Mycotoxins Increases Toxicity of Treated Food Crops

(Beyond Pesticides, April 18, 2025) A recent study published in Foods assesses the ability of the fungicide azoxystrobin (AZX) and naturally occurring toxins produced by certain fungi, known as mycotoxins, to display effects of cytotoxicity (cell damage). These effects were evaluated using three common mycotoxins found in food, including ochratoxin A (OTA), deoxynivalenol (DON), and T-2 toxin as mixtures with AZX within human hepatocarcinoma (HepG2) cell cultures. In analyzing combinations of these compounds at sublethal concentrations, the authors find modified toxicological behavior and synergistic effects that highlight the complexities of chemical mixtures, and potential threats to liver health through dietary exposure to both toxicants and toxins, that are not adequately regulated for their interactions. While fungicides, like azoxystrobin, are intended to prevent or control fungal diseases, resistance to these pesticides can increase the presence of fungi, and subsequent mycotoxins, on crops. This scenario allows for co-exposure of fungicides and mycotoxins within food products that present a risk to consumers. These chemicals can threaten human health individually, as the researchers confirm in their study, but present a greater threat in combination. The mixture of AZX with all three mycotoxins exhibits the highest toxicity, with synergistic effects at all tested concentration levels. […]

Share

17
Apr

Findings Show Endocrine-Disrupting Glyphosate Weed Killer Threatens Women’s Reproductive Health

(Beyond Pesticides, April 17, 2025) A literature review in Reproductive Sciences finds glyphosate (GLY) and glyphosate-based herbicides (GBH) impact women’s reproductive health, adding to the long list of documented harm from this widely used weed killer. The authors note, “Considering the widespread use of GLY, the controversy regarding its endocrine-disrupting potential and reproductive toxicity, and the innumerable lawsuits filed against Bayer and Monsanto by consumers for morbidities related to Roundup™ exposure, the purpose of this review is to summarize the current literature on the potential adverse effects of GLY and GBHs on the female reproductive tract and discuss possible clinical implications on reproductive health outcomes, including polycystic ovarian syndrome (PCOS), endometriosis, and female fertility.”  Glyphosate and aminomethylphosphonic acid (AMPA), the primary metabolite (breakdown product) of GLY, are found throughout the environment in soil and water, as well as in samples of blood, urine, seminal plasma, and breast milk. Studies have detected residues in farmworkers, as well as “in the urine of 60–80% of the general public in the USA, including pregnant women and children.” (See studies here, here, and here.) The ubiquitous use of GLY and GBH, and subsequent persistence, threatens the health and well-being of all.  Previous studies have […]

Share

08
Apr

Literature Review of Over 200 Studies Highlights Pesticide Threats to Women’s Reproductive Health

(Beyond Pesticides, April 8, 2025) A comprehensive literature review in Environment & Health analyzes evidence from human biomonitoring, epidemiological studies, and toxicological studies that link adverse effects on women’s reproductive health, specifically impacting the ovary, to pesticide exposure. In examining the scientific literature, consisting of over 200 studies performed in the last 25 years, the authors find pesticide exposure threatens women’s health through ovarian dysfunction. “Epidemiological studies have shown that pesticide exposures are associated with early/delayed menarche [first occurrence of menstruation], menstrual cycle disorders, early menopause, long time to pregnancy, polycystic ovary syndrome, primary ovarian insufficiency, infertility, and implantation failure in women,” the researchers state. They continue, “Both in vivo [in animals] and in vitro [in cells] studies have shown that exposure to pesticides disrupts the estrous cycle, reduces the follicle pool, alters hormone levels, and impairs oocyte [egg] maturation.” These reproductive implications are noted with many different classes of pesticides, such as insecticides, including organochlorine pesticides (OCPs), organophosphates (OPs), pyrethroids, and neonicotinoids, as well as herbicides and fungicides. The authors, however, comment on present research gaps: “Much of the available epidemiological evidence focuses on legacy insecticides, such as OCPs, and a subset of insecticides that are still in use […]

Share

03
Apr

Research Spotlights New Hazard Severity of Chlorpyrifos, Ag Insecticide Widely Found in Food Supply

(Beyond Pesticides, April 3, 2025) As highlighted by Beyond Pesticides in recent comments to the U.S. Environmental Protection Agency (EPA), chlorpyrifos (CPF) has been under scrutiny for decades due to associated adverse health effects, noted particularly in the extensive and consistent scientific evidence of neurotoxic dangers to children’s health. The latest research on CPF, published in Environmental Toxicology and Genes & Diseases, reveals additional threats to the immune system and male reproduction that are not captured in current EPA risk assessments of chlorpyrifos and raises serious health questions, given that residues are found throughout the food supply. CPF, a widely used organophosphate insecticide in agriculture, is a cholinesterase inhibitor that binds irreversibly to the active site of an essential enzyme for normal nerve impulse transmission, acetylcholine esterase (AChE), inactivating the enzyme. Many insecticides, including organophosphates and carbamates, target AChE, causing them to be highly toxic to both insects and mammals that have this enzyme as a crucial part of their nervous systems. The history of chlorpyrifos exemplifies the failure of pesticide law and policy, as this chemical, among many others, not only has direct adverse health effects but is contributing to the climate crisis, biodiversity collapse, and disproportionate levels of […]

Share

02
Apr

Study Finds Reproductive System Effects in Adolescents with Prenatal Pesticide Exposure

(Beyond Pesticides, April 2, 2025) In examining prenatal residential proximity of documented pesticide spraying in California to the menstrual cycle characteristics of 273 Latina adolescents, researchers report in the American Journal of Epidemiology a positive association between exposure to the insecticide methomyl and heavy bleeding. Other pesticides appear to influence menstrual symptoms as well. “Adolescents’ menstrual cycle characteristics can be ‘vital signs’ of health and impact quality of life,” the authors share. They continue, “To our knowledge, this is the first study to examine the association between prenatal pesticide exposure and menstrual outcomes in adolescents of any demographic group.” Menstrual cycle characteristics, such as dysmenorrhea (painful or uncomfortable menstrual cramps), irregularity, and heavy menstrual bleeding, can also be indicators of underlying health conditions, including endometriosis, polycystic ovary syndrome (PCOS), thyroid dysfunction, and bleeding disorders. By associating the pesticide exposure of mothers during pregnancy to impacts on their children, the researchers highlight important health risks for women and young girls that are often disregarded. “The prenatal period is a critical period of reproductive development that may be particularly sensitive to endocrine disruption,” the researchers share. As previously reported by Beyond Pesticides, endocrine-disrupting chemicals are any synthetic or natural compounds that hinder […]

Share

01
Apr

Multi-Billion Verdict Against Bayer/Monsanto in GA as Legal Rights Under Attack in the State and Nationwide

(Beyond Pesticides, April 1, 2025) With the second largest award of nearly $2.1 billion (see reporting on largest), a jury in Georgia state court on March 21 found the pesticide manufacturer Bayer/Monsanto guilty of causing a man’s non-Hodgkin’s lymphoma after use of the company’s glyphosate-based weedkiller RoundupTM product. The jury’s award includes $65 million in compensatory and $2 billion in punitive damages, as reported by the Associated Press and Courtroom View Network. This verdict in Barnes v. Monsanto (2025) comes amid a concerted effort by Bayer and other chemical and agribusiness groups to take away the main legal argument, “failure-to-warn,” for the type of litigation that pesticide exposure victims have commonly used to hold companies accountable. This is happening as Governor Brian Kemp of Georgia considers signing into state law a pesticide immunity bill that will prevent future litigation like this in the state. In a deregulatory environment, the courts and state governments are viewed as critical backstops, given the dismantling of the U.S. Environmental Protection Agency’s (EPA) regulatory apparatus and extremely limited Congressional oversight. History of Litigation Bayer has lost almost all of the cases filed against it for compensation and punitive damages associated with the plaintiffs’ charge that […]

Share

27
Mar

New Herbicide that Mimics Hormones Threatens Nontarget Aquatic Species and Biodiversity, Study Finds

(Beyond Pesticides, March 27, 2025) In Ecotoxicology, results of a study on Nile tilapia (Oreochromis niloticus) exposed to florpyrauxifen-benzyl (FPX) suggest the new herbicide causes oxidative stress (imbalances affecting the body’s detoxification abilities that lead to cell and tissue damage), with specific genotoxic (damage to genetic material) and hepatotoxic (damage to the liver) effects on nontarget species. The authors state: “According to the available literature, no data exist on the toxicity of FPX in fish. Therefore, this study aims to investigate, for the first time, the potential toxicity and associated mechanistic effects of the pyridine-carboxylic acid herbicide (FPX) on the non-target species, Nile tilapia.” According to the Wisconsin Department of Natural Resources, “Florpyrauxifen-benzyl is a systemic herbicide (i.e., it moves throughout the plant tissue). It is a WSSA Group 4 herbicide, meaning that the mechanism of action is by mimicking the plant growth hormone auxin and causing excessive elongation of plant cells, ultimately killing the plant.” The researchers, from Menoufia University, the Agricultural Research Center, and Cairo University in Egypt, focus on FPX as it is the active ingredient in Divixton 2.5% EC, a newly released herbicide used in rice fields and applied directly to freshwater aquatic bodies for emergent […]

Share

25
Mar

Research Finds Triazole Fungicides Induce Cardiotoxicity, Threatening Cardiovascular Health

(Beyond Pesticides, March 25, 2025) An editorial in Expert Review of Cardiovascular Therapy finds that triazole fungicides pose a significant risk of cardiotoxicity with “growing concerns regarding their safety for human health, especially in long-term exposure,” the authors share. After analyzing the known mechanisms of cardiotoxicity of triazole pesticides in mammals, they conclude that “the most effective approach to mitigating triazole-induced cardiotoxicity lies in prevention.”  Triazoles, a class of fungicides, target fungi by inhibiting the biosynthesis of ergosterol, an essential component of their cell membranes. As the researchers share, “Compounds such as tebuconazole, propiconazole, and difenoconazole are among the most used triazoles in agriculture.” Triazoles are utilized as antifungal medications, despite the rise of resistant infections, in addition to their use as systemic pesticides on many fruit and vegetable crops, including grapes, wheat, corn, and soybeans.   As Beyond Pesticides’ previous coverage indicates, many triazole fungicides in the U.S. are registered for use despite evidence of endocrine disruption established over a decade ago in a U.S. Geological Survey report. These pesticides exhibit common mechanisms of toxicity often disregarded in U.S. Environmental Protection Agency (EPA) risk assessments, with a multitude of studies showcasing the myriads of health threats that the agency does […]

Share

24
Mar

FDA Asked to Stop Food and Chemical Industry from Classifying “Safe” Food Ingredients without Review

(Beyond Pesticides, March 24, 2025) In establishing the Make America Healthy Again Commission in February, the President tapped Secretary of the U.S. Department of Health and Human Services Robert F. Kennedy, Jr. to chair the interagency panel. The stated goal, as described in the founding proclamation, is “drastically lowering chronic disease rates and ending childhood chronic disease.” The commission document states, “Overall, the global comparison data demonstrates that the health of Americans is on an alarming trajectory that requires immediate action.” In this context, on March 10, Secretary Kennedy directed Food and Drug Administration (FDA) Acting Commissioner Sara Brenner, MD to take steps to explore potential rulemaking to revise its Substances Generally Recognized as Safe (GRAS) Final Rule and related guidance to eliminate the self-affirmed GRAS pathway—allowing the food and chemical industry to assign GRAS status to food ingredients without oversight. This “pathway” to allowing food additives has long been recognized as a loophole that allows unidentified and potentially harmful additives in food, including by the 2010 U.S. General Accountability Office (GAO) report, Food Safety: FDA Should Strengthen Its Oversight of Food Ingredients Determined to Be Generally Recognized as Safety.  Beyond Pesticides launched an effort this week to tell FDA to eliminate the self-affirmed […]

Share

17
Mar

Can FDA Step In When EPA Fails to Ensure Safety from Pesticide Mixtures in Food?

(Beyond Pesticides, March 17, 2025) When Secretary of Health and Human Services Robert F. Kennedy, Jr. announced last week that he is directing the U.S. Food and Drug Administration (FDA) to explore rulemaking to review substances in food affirmed by the food companies to be Generally Recognized as Safe (GRAS), he said he is “committed to promoting radical transparency to make sure all Americans know what is in their food.” The issue of independent review of the food industry’s GRAS declarations has long been the subject of critiques raising public health concerns. As this issue emerged, on another food safety issue, Beyond Pesticides is asking  FDA to use its broad authority under the Federal Food, Drug, and Cosmetic Act to “ensur(e) that human foods and animal feeds are safe” from residues of pesticide mixtures, in light of new troubling scientific data. Under various memoranda of understanding between FDA, the U.S. Environmental Protection Agency (EPA), and the U.S. Department of Agriculture (USDA) going back decades, FDA could consult with EPA on food safety issues ignored by the agency, including  recent data published in Pesticide Biochemistry and Physiology, which “suggest that combined [pesticide] exposure may further amplify the toxicity and compromise the intestinal […]

Share

13
Mar

Study of Pesticide Mixtures and Intestinal Barrier Dysfunction Further Highlights Regulatory Deficiencies

(Beyond Pesticides, March 13, 2025) Study results published in Pesticide Biochemistry and Physiology “suggest that combined [pesticide] exposure may further amplify the toxicity and compromise the intestinal barrier.” The researchers studied the toxic effects of the insecticides abamectin and spirodiclofen, as well as the fungicide fluazinam, individually and in combination. In exposing mice and Caco-2 cells to these pesticides, the results show the disruption of intestinal functions and highlight the need to assess potential synergistic effects of pesticide mixtures as a part of the regulatory review process.  Effects on the intestinal barriers of mice represent a threat to “the first line of defense against the external environment,” the researchers say. The intestinal mucosal epithelial structure plays an important role in preventing harmful substances from entering the intestines and causing damage to cells.  [Caco-2 cells represent a human cell line, derived from a colon cancer patient’s tissue, and mimic the small intestine. These cells are vital in research as a model of the intestinal epithelial barrier.]  “Currently, most studies investigating the effects of pesticide residues on the barrier function of Caco-2 cells concentrate on the exposure to a single residue, while the potential toxic effects arising from the concurrent presence of multiple pesticide […]

Share

11
Mar

Study Finds Spermiotoxicity and Impacts on Male Mammal Fertility with Ipconazole Fungicide Exposure

(Beyond Pesticides, March 11, 2025) A study in Toxics analyzes ipconazole, a triazole fungicide often used as a coating on treated seeds and as a foliar treatment on the leaves of plants. “Triazole pesticides are widely used throughout the world, but their abuse causes toxic effects in non-targeted organisms,” the researchers state. In the current study, unintended reproductive effects are noted in male sheep (ram) and pigs (also known as porcine or swine). This research focuses on the impact of ipconazole exposure on spermatozoa (sperm) in two mammal species and finds spermiotoxicity through significantly reduced sperm viability, as well as alterations in enzyme and gene expression related to fertility.  “To our knowledge, this is the first study to evaluate the cytotoxic effect of the triazole ipconazole on mammalian spermatozoa,” the authors share. This analysis utilizes semen samples from the Reproductive Biotechnology Laboratory of the Major National University of San Marcos in Lima, Peru, the university where six of the nine researchers are Faculty of Veterinary Medicine.   “The sperm were exposed to ipconazole concentrations of 1, 5, 10, 50 and 100 ÂľM, and to a control without ipconazole,” they say. Similar concentrations have been used in previous cytotoxicity studies with ipconazole. […]

Share

10
Mar

Catastrophic Harm to Women from Pesticides Drives Call for Their Elimination

(Beyond Pesticides, March 10, 2025) Following International Women’s Day, celebrated on March 8, 2025, the poignant findings on women, gender, and hazardous substances in a United Nations report raise critical issues of concern and cause for urgent action to phase out petrochemicals. The Report of the Special Rapporteur on the implications for human rights of the environmentally sound management and disposal of hazardous substances and wastes, by Marcos Orellana, was delivered to the 79th Session of the United Nations General Assembly in July 2024. Excerpts from the report follow: “Women make up roughly 60 to 70 per cent of the agricultural labour force in developing countries where pesticides and pesticide handling are especially poorly regulated. In Zambia, for example, two thirds of the labour force is engaged in agriculture, and 78 per cent are women farmers and peasants. Women there play a significant role in pesticide application, often without any or adequate personal protective equipment, especially during activities such as weeding, harvesting, and washing pesticide-laden clothes.” “In higher-income countries, women who do agricultural work are often poor and/or migrants; pesticides are one of many dimensions of marginalization and damage to their well-being. The European agriculture sector uses many seasonal and […]

Share