(Beyond Pesticides, May 18, 2026) As the studies continue to mount on the adverse effects of exposure to low levels of organophosphate insecticides, the calls for banning the chemicals are growing. Beyond Pesticides announced an action to “Tell Congress, FDA, and EPA that it is past time to stop the manufacture and use of all organophosphate pesticides, which damage the nervous system and brain at low levels.” There are alternatives to these chemicals that support productive and profitable farming operations. Defying the often-repeated claim that organophosphate pesticide effects occur only at high doses, a recent study by researchers at University of California, San Diego, and the Fundación Cimas del Ecuador in Quito, Ecuador, establishes for the first time the pattern of adverse developmental effects that low-level exposure has on healthy neurological and brain development in children. It is firmly established that widely used organophosphate pesticides in food production and other sites are severely toxic to a broad range of organisms. In what is known as their “classic” mechanism of action, they inhibit acetylcholinesterase (AChE), an enzyme that breaks down the neurotransmitter acetylcholine (ACh), particularly in neuromuscular junctions in the brain. Organophosphates are nerve agents, originally developed by the German company IG Farben (a […]

(Beyond Pesticides, May 13, 2026) Published in Toxics, a review finds that per- and polyfluoroalkyl substances (PFAS) can heighten the risks to exposed organisms from environmental contaminants. Mixtures of these compounds can negatively impact the nervous, cardiovascular, immune, and reproductive systems, particularly in aquatic organisms, and threaten overall biodiversity. The review highlights synergistic effects (greater in combination) observed in mixtures, such as PFAS with pesticides and microplastics, that can cause enhanced oxidative stress, neurotoxicity, developmental defects, and reproductive dysfunction, among others. “The objectives were to evaluate the toxicological effects of mixtures of the selected contaminants with PFAS on aquatic organisms to better understand biological responses in animals,” the study authors explain. “Based on our review, data suggest that PFAS can modify the toxicity of co-occurring pollutants.” Background PFAS were first created in the 1930s and have since been used in many industries and in the production of many products. The multitude of PFAS sources and exposure routes leads to widespread contamination of the environment and organisms. PFAS in agriculture represents a large source, as PFAS can be pesticide active ingredients, used in the plastic containers that pesticides are stored in, and as surfactants in pesticide products. Additionally, PFAS are used in many other […]

(Beyond Pesticides, May 8, 2026)  A study from Ecuador establishes for the first time the developmental pattern of nervous system toxicants—still widely used in agriculture, mosquito control, and landscaping—on healthy neurological and brain development in children. It is firmly established that widely used organophosphate pesticides are severely toxic to a broad range of organisms. In what’s known as their “classic” mechanism of action, they inhibit acetylcholinesterase (AChE), an enzyme that breaks down the neurotransmitter acetylcholine (ACh), particularly in neuromuscular junctions in the brain. Not enough AChE leads to a buildup of ACh in motor neurons. Organophosphates deplete AChE, and an acute dose can paralyze the heart and lung muscles, causing death. Chronic exposures are implicated in numerous neurodegenerative diseases, including Alzheimer’s, Parkinson’s, and amyotrophic lateral sclerosis (ALS). Beyond Pesticides’ Gateway on Pesticide Hazards and Safe Pest Management has detailed information on the organophosphates malathion, chlorpyrifos, diazinon, and others. Acetylcholine and AChE are vital biological chemicals conserved across the animal kingdom, from humans to insects and everything in between. Yet there is no established baseline for normal levels of ACh and AChE in humans. Comparing biomarkers of organochlorine exposure with normal values would be a major step forward in assessing the influence […]

(Beyond Pesticides, May 7, 2026) Adding to the wide body of science on pesticide-induced cancer, researchers from the Icahn School of Medicine at Mount Sinai’s Department of Hematology and Medical Oncology and Department of Environmental Medicine find that environmental and occupational exposures increase the risk of developing multiple myeloma (MM), a type of blood cancer. As published in Blood Reviews, the literature review highlights how exposure to contaminants, such as pesticides, dioxins, combustion byproducts, and ambient air pollution, can cause MM through mechanisms of oxidative stress, DNA damage, and aryl hydrocarbon receptor signaling, as well as influence disease biology through immune dysregulation. “Earlier epidemiologic studies suggested associations between environmental exposures and disease risk, but few have used modern geospatial or exposomic [totality of environmental exposure relating to health effects] methods capable of capturing exposure complexity,” the authors write. They continue: “Advances in data integration, spatial modeling, and molecular profiling now make it possible to revisit these questions with greater precision and biological context. This review summarizes current evidence on environmental exposures in plasma cell disorders and frames a research agenda for integrating exposomic data to improve exposure resolution and evaluate plausible mechanisms in MM.” Background Multiple myeloma is an incurable […]

(Beyond Pesticides, May 6, 2026) Adding to the wide body of science highlighting the adverse effects of pesticides on pollinators, as extensively documented in Daily News and What the Science Shows on Biodiversity, a study published in Insects finds threats to Italian honey bees (Apis mellifera ligustica) following exposure to insecticides with contrasting toxicity levels. Both the high toxicity and low toxicity compounds impact honey bee gut bacteria and gut microbial composition, showing how even “reduced risk” insecticides can have sublethal effects and jeopardize pollinator health. As the authors point out, “Honey bees depend on a small but highly specialized community of gut bacteria that help them digest food, resist infections, and cope with environmental stress.” Because of this, chemicals that disrupt the honey bee gut microbiome can threaten their survival. In the current study, the researchers analyze two compounds to determine adverse impacts on honey bees’ gut microbiota: emamectin benzoate-lufenuron (EB-LFR), an avermectin insecticide with high toxicity, and RH-5849 (1,2-dibenzoyl-1-tert-butylhydrazine), a non-steroidal ecdysone agonist (mimicking the action of the insect molting hormone) and insect growth regulator with reported lower toxicity. The results reveal that both toxicity levels can harm gut microbial composition, with EB-LFR “associated with observed reductions in […]

(Beyond Pesticides, May 1, 2026) A study in Psychiatry Research, entitled “Toxic Exposure and Rates of Suicidal Thoughts and Behaviors Among U.S. Military Veterans,” adds to the body of science linking poorer mental health among military members with exposure to environmental contaminants. While previous research focuses on mental health broadly, the current observational cohort study focuses on exposure to toxic substances and suicidal thoughts and behaviors (STBs) through the analysis of data from 248,926 U.S. veterans enrolled in the Million Veteran Program (MVP). In comparing self-reported exposures to nine toxicants, including Agent Orange, chemical/biological weapons, anthrax vaccine, solvents/fuels, petroleum combustion products, lead, other metals, pesticides, and open-air burn pits, and mental health records, the researchers find that military veterans with higher toxic exposures are more likely to have STBs. The authors also report that these associations occur across all major service cohorts (pre-Vietnam, Vietnam, post-Vietnam, Gulf War, and post-9/11 eras). “Our work contributes to growing evidence that veterans who report more toxic exposures are more likely to have STBs, consistent with greater risk for other mental health outcomes (e.g., depression, PTSD [post-traumatic stress disorder]),” the researchers conclude. Importance and Background Military members experience increased health risks with exposure to environmental […]

(Beyond Pesticides, April 28, 2026) In Chemical Research in Toxicology, researchers from the Universitat Rovira i Virgili in Catalonia, Spain highlight the threats to human and environmental health with “combined exposures to multiple chemical toxicants, including industrial chemicals, heavy metals, pesticides, endocrine-disrupting chemicals (EDCs), and per- and polyfluoroalkyl substances (PFAS).” As these compounds are encountered in mixtures in real-world settings, the resulting interaction can have additive or synergistic effects that risk assessments fail to adequately capture. As the authors point out: “This leads to a systematic underestimation of health risks, particularly for vulnerable populations. Despite robust evidence on mixture toxicity, major regulatory frameworks such as the U.S. Toxic Substances Control Act (TSCA) and the EU’s [European Union] REACH program continue to assess chemicals in isolation.” Importance and Background Environmental toxicants are ubiquitous throughout nature and within all organisms. In humans, these compounds can accumulate, referred to as ‘Body Burden’, which encompasses numerous chemicals such as pesticide mixtures. “Critically, organisms are rarely exposed to a single chemical in isolation,” the researchers note. “Rather, they continuously encounter complex mixtures of contaminants whose combined effects may differ substantially from those predicted by examining each substance individually.” As the authors explain, regulatory agencies underestimate […]

(Beyond Pesticides, April 24, 2026) In a review of scientific literature documenting pesticide contamination in the atmosphere, international researchers find human and ecosystem exposure even in remote and distant areas. As published in the Journal of Hazardous Materials, the authors state: “Atmospheric transport of pesticides is a globally significant yet widely underestimated driver of human and ecological exposure, with contamination documented far beyond treated fields. This review provides a novel integrated synthesis, bridging emission pathways, atmospheric transformation processes, monitoring evidence, model limitations, and regulatory gaps to deliver a comprehensive understanding of the fate and impacts of pesticides in the atmosphere.” In analyzing the current knowledge on pesticide emissions, through both drift and volatilization (process where a solid or liquid converts into a gas or vapor), the researchers highlight “the widespread detection of both current-use and banned pesticides in environmental matrices far from their application,” along with the resulting implications for human health and environmental health. As the current risk assessment framework “fails to adequately address the perturbations caused by the atmospheric transport of pesticides,” the urgent need to transition away from chemical-intensive practices grows stronger. Background While this review highlights regulatory gaps in the European Union (EU), the cited scientific […]

(Beyond Pesticides, April 14, 2026) A novel study mapping pesticide mixtures and cancer risk, published in Nature Health, “reveals a robust spatial association between environmental pesticide exposure risk and cancer incidence.” The team of international researchers incorporates pesticide risk modeling with Peruvian National Cancer Institute (INEN) registry data to map pesticide-induced cancer clusters in Peru, finding significant associations between pesticide mixtures and cases of carcinogenicity. The study analyzes 31 active ingredients to identify pesticide-associated cancer hotspots, none of which are classified as carcinogenic on their own by international standards. When combined as pesticide mixtures, as experienced in real-world environments, heightened risks and synergistic effects are noted. “Collectively, these findings strongly support a mechanistic [causal] link between pesticide exposure and cancer, challenging assumptions of human non-carcinogenicity derived from reductionist experimental models,” the authors state. “This study redefines the exposome [measure of all environmental, dietary, lifestyle, and social exposures of an individual] as a lineage-conditioned, mechanistically tractable framework and shows how complex pesticide mixtures can contribute to carcinogenic trajectories, with profound and far-reaching implications for global health policy and socio-ecological equity.” Background An extensive body of scientific literature connects individual pesticide active ingredients to a wide array of health and environmental effects […]

(Beyond Pesticides, April 10, 2026) An important study not previously covered in Daily News, “Use of Genetically Modified Organism (GMO)-Containing Food Products in Children,” raises serious concerns about children’s dietary exposure to pesticides, particularly the weed killer glyphosate, that are heavily used in the production of genetically engineered crops. Published in Pediatrics by the American Academy of Pediatrics, the lead authors Steven A. Abrams, MD, FAAP, Jaclyn Lewis Albin, MD, FAAP, and Philip J. Landrigan, MD, FAAP call attention to the widespread use of genetic engineering (GE) and GMOs in the U.S. food supply and the subsequent health risks for children and consumers. The authors, in collaboration with the Committee on Nutrition, Council on Environmental Health and Climate Change Executive Committee, and additional medical professionals and researchers, also maintain that pediatricians have the opportunity to provide education and “lead conversations with families about the health impact of certain foods, provide nutritional guidance, and help filter the overwhelming volume of information.” By supporting parents in making informed nutrition choices, pediatricians can help shape decisions that impact the long-term health of children and advocate for choosing organic certified products. As the authors state: “Although GMO technology could be used to increase the micronutrient […]

(Beyond Pesticides, April 7, 2026) In the International Journal of Molecular Sciences, a study of gestational (during pregnancy) exposure to the neonicotinoid insecticide thiacloprid shows epigenetic effects (alterations in genes without altering underlying DNA) within prostate tissues. To analyze the role of gene expression in subsequent generations after initial thiacloprid exposure, the authors exposed pregnant outbred Swiss mice to the insecticide in order to assess the offspring for multiple generations. As a result, the researchers from the Université de Rennes in France state, “Our study revealed that exposure to thiacloprid induces [cell] proliferation and is associated with epigenetic alterations in the sperm of genes important for prostate development.” Increased cell proliferation in the prostate can cause the development of conditions such as benign prostatic hyperplasia (BPH) and prostatic intraepithelial neoplasia (PIN), and lead to prostate cancer. The study also finds elevated levels of specific biomarkers within the prostates of both the first and third generations, including phosphorylated histone H3, a marker crucial for cell division. Hox gene expression in both generations was also impacted, which plays a role in prostate development, based on the altered DNA methylation (abnormal changes) in the sperm of the analyzed mice. “In this study, we […]

(Beyond Pesticides, April 3, 2026) A literature review published in Chemico-Biological Interactions links pyrethroid insecticide exposure to cardiac dysfunction. Through a systematic review and meta-analysis of previous research through July 2025, the authors find emerging evidence that indicates pyrethroids induce adverse cardiovascular effects through pathways of inflammation, oxidative stress, and myocardial injury (damage to the heart muscle). “The meta-analytic findings of this study offer the first comprehensive overview of the cardiotoxic effects of pyrethroids, encompassing electrophysiological, biochemical, inflammatory, and redox disturbances,” the researchers state. “Together, these findings indicate that pyrethroids disrupt cardiac electrical stability and induce cytotoxic [killing or damaging cells], inflammatory, and oxidative damage.” Study Importance Scientific literature connecting various classes of pesticides to adverse health effects continues to mount, with synthetic pyrethroids emerging as a class of increasing concern. Due to their broad spectrum of activity, pyrethroids are extensively used in agriculture and land management but can persist in the environment and can cause neurotoxicity, endocrine disruption, reproductive dysfunction, and cardiovascular health implications. (See here and here.) In particular, pyrethroid exposure is associated with increased risks of developing cardiovascular disease. (See studies here, here, here, and here.) “Cardiac electrical activity is regulated by mechanisms that are highly sensitive […]

(Beyond Pesticides, April 1, 2026) Researchers at the University of Washington and members of the Washington State Liquor and Cannabis Board published a commentary piece in Clinical Therapeutics highlighting the growing inadequacy of state-level regulatory safeguards for pesticide contamination of cannabis products. The Environmental Protection Agency (EPA) is unable to assess pesticide residues, nor is it permitted to set tolerance limits under the Federal Insecticide, Fungicide, and Rodenticide Act (FIFRA), because, according to the Controlled Substances Act (CSA), cannabis is a Schedule 1 narcotic, meaning there is “no accepted medical use.” As a result, EPA cannot conduct a full assessment of pesticide exposure associated with inhalation, ingestion, and dermal (skin) adsorption. There is an ongoing rescheduling process that was proposed in 2024 and followed up with an executive order in late 2025 to transition cannabis toward Schedule III status, suggesting that there would be an opening for EPA to promulgate rulemaking to support state-level regulations if it were to move forward. An analysis of active legislation in state legislatures for the 2026 session highlights the concerns—at least 14 states (including Connecticut, California, Georgia, Hawai’i, Illinois, Iowa, Kansas, Kentucky, Maine, New Hampshire, Oklahoma, Virginia, West Virginia, and Wisconsin) had bills to […]

(Beyond Pesticides, March 31, 2026) A statement decrying chemical company secrecy was released today by over 200 grassroots, health, farm, farmworker, environmental, and consumer groups, socially responsible corporations, over 340 citizens from 46 states, and international partners. The statement, released before the U.S. Supreme Court tomorrow reaches the final deadline for submission of amicus briefs in a case in which Bayer/Monsanto argues, with support of the Trump administration, that it should not be required to disclose on its product labels the potential hazards of its pesticide products. Oral arguments in the case will be heard on April 27, with a decision anticipated in June. Decades of law have upheld the legal argument that chemical companies are liable for their failure to warn users of their pesticides about the harm that they could cause. Bayer/Monsanto is attempting to reverse years of case law and billions of dollars in jury verdicts and future cases in which the company has been held liable for causing cancer but not warning product users. See statement, Stop Chemical Company Secrecy of Pesticide Product Hazards. Chemical Industry State Campaign The chemical industry last year launched a multi-pronged campaign to establish immunity from litigation by those who have […]

(Beyond Pesticides, March 30, 2026) Through today, organizations, institutions, and corporations can sign on to a public statement calling for chemical companies to continue to be held liable for harming but not warning people who use their pesticide products. The statement, joined by grassroots, health, farm, farmworker, environmental and consumer groups, and socially responsible corporations, will be released tomorrow—just as U.S. Supreme Court begins on April 1 considering Monsanto/Bayer’s claim that the company is not responsible for failing to warn those whose cancer was found by a jury trial to be caused by its weed killer glyphosate (RoundupTM). Groups can sign on to the statement by 5:00pm (Eastern) by clicking here. In the case before the U.S. Supreme Court case, Monsanto v. Durnell, Monsanto/Bayer is seeking to overturn over $10 billion in jury verdicts and settlements and stop future litigation on their failure to warn about the potential cancer effects of glyphosate/RoundupTM. If Monsanto/Bayer wins, chemical companies will be able to legally withhold information on their pesticide product hazards not required to be disclosed by the U.S. Environmental Protection Agency (EPA).  Bayer/Monsanto wants to overturn decades of legal precedent, including a previous Supreme Court decision, which establishes EPA-required, minimum pesticide product label language, […]

(Beyond Pesticides, March 27, 2026) In a study of birth outcomes in Arizona, published in the Journal of Exposure Science & Environmental Epidemiology, researchers find that preconception and prenatal exposure to certain carbamates, organophosphates, and pyrethroids increases the risk of lower Apgar scores, a metric used to assess neonatal health at one minute and five minutes after birth. The results reveal that exposure to “several pesticide active ingredients at any point during preconception and/or pregnancy were associated with increased odds of low Apgar scores: the carbamates carbaryl and formetanate hydrochloride; the organophosphates diazinon and tribufos; and the pyrethroid cypermethrin.” This multi-institutional study, led by the University of Arizona with researchers from Harvard Chan School of Public Health and UCLA Fielding School of Public Health, provides novel insights, as it incorporates pesticide exposure over a 15-year period both before conception and throughout pregnancy. “To analyze associations of preconception and prenatal exposures to carbamate, organophosphate, and pyrethroid pesticide classes and 25 individual active ingredients with newborn Apgar scores to evaluate the relationship between these exposures and neonatal health,” the authors explain. They continue: “We used pesticide use registry and birth certificate data from 2006 to 2020, linked as part of the Arizona […]

(Beyond Pesticides, March 26, 2026) A review of pesticide exposure from a family member working in agriculture (“take-home” residues) finds that pesticide levels in the home are elevated between 2.6- and 3.7-times. This and other nonoccupational exposure data from homes are drawn from the Agricultural Health Study (AHS), a National Cancer Institute (NCI) and National Institute of Environmental Health Sciences (NIEHS) prospective study of cancer and other health outcomes in a cohort of licensed pesticide applicators and their spouses from Iowa and North Carolina. Between 1993 and 1997, with follow-up between 1999 and 2021, AHS tracks occupational and nonoccupational exposure and subsequent health effects from pesticide exposure. The current study, published in Environmental Advances, reexamines a quantitative analysis on nontarget, “active-ingredient-specific” exposure to pesticides from multiple pathways—applying new criteria to AHS spousal exposure to the insecticide chlorpyrifos and the herbicide atrazine. The three pesticide exposure pathways include take-home, agricultural drift, and residential use. Building on a 2019 study, researchers consider data from additional studies published between 2019 and 2024, “providing support that all three pathways contribute to pesticide exposure.” More importantly, the updated estimates of nontarget exposure to chlorpyrifos and atrazine are overall strengthened by the incorporation of new data, highlighting the […]

(Beyond Pesticides, March 25, 2026) A literature review, published in Diseases, showcases the wide body of scientific literature linking pesticide exposure to liver disease through both apoptotic (programmed cell death without triggering inflammation) and non-apoptotic (regulated cell death with an inflammatory response) pathways. “In summary, our study confirms that pesticides carry significant health risks and sheds light on the underreported mechanisms that can drive their overall toxicity as a whole and hepatotoxicity [liver] in particular,” the researchers state.  In addition to analyzing the science on pesticide-induced apoptosis, the researchers “systematically illustrated an underappreciated mechanism of pesticide-induced overall and hepatic toxicity, i.e., the ability to induce non-apoptotic regulated cell death (RCD) pathways such as ferroptosis, necroptosis, and pyroptosis.” They continue, saying, “Importantly, our review stresses the contribution of pesticide-induced cell death modes to inflammation and immunity regulation in hepatic pathology.” Background Pesticides, as a comprehensive group, can be subdivided into classes based on their targets: rodenticides (rodents), herbicides (weeds), insecticides (insects), fungicides (fungi), nematicides (nematodes), acaricides (mites and ticks), and bactericides (bacteria). The use of these pesticides, particularly in agriculture, has skyrocketed over recent decades. As the authors state: “In 2019, the total pesticide market size was estimated to approach $85 […]

(Beyond Pesticides, March 12, 2026) The science connecting pesticide exposure to neurotoxicity continues to mount. A study in Discover Toxicology highlights neurotoxic pollutants as significant environmental threats, showcasing the adverse impacts on vertebrates’ neurological health from pesticides, including organophosphates, carbamates, and organochlorines. “These substances disrupt normal neurophysiological functions by impairing neurotransmission, generating oxidative stress, provoking neuroinflammation, and initiating neuronal cell death,” the authors say. They continue, “Such disturbances are linked to cognitive deficits, motor impairments, and abnormal neural development.” Neurological conditions can manifest as headaches, muscle weakness, tremors, paralysis, coordination challenges, vision loss, hallucinations, vertigo, seizures, memory loss, slurred speech, trouble breathing with minimal exertion, and more. The range of adverse effects from low-dose, long-term exposure and low-dose (or subchronic) exposure during developmental phases of life raises serious questions about the adequacy of the regulatory review of pesticides, which focuses on acute high and lethal dose exposure. One study on the neurotoxicity of pesticides, published in Chemosphere, concludes, “New regulatory and preventive measures to mitigate the neurotoxic effects of pesticides are needed.” (See also Daily News.) Even at low concentration, chronic exposure to pesticides and other environmental contaminants “poses serious ecological and health concerns” that occur as these chemicals “bioaccumulate […]

(Beyond Pesticides, March 6, 2026) The Farm Bill—the Farm, Food, and National Security Act of 2026, H.R. 7567—reported out of the Agriculture Committee in the U.S. House of Representatives yesterday strips environmental and public health protections from pesticides, reversing over 90 years of environmental laws adopted by Congress to protect farmers, consumers, and the environment that stretch back to the first Farm Bill in 1933. The Committee rejected the Protect Our Health Amendment, sponsored by Rep. Chellie Pingree (D-ME), which would have ensured that the final bill maintain three core safeguards in current law: (i) Judicial review of chemical manufacturers‘ failure to warn about pesticide hazards; (ii) Democratic right of local governments in coordination with states to protect residents from pesticide use; and, (iii) Local site-specific action to ensure protection—the safety of air, water, and land from pesticides under numerous environmental statutes. All Republicans and one Democrat (Rep. Adam Gray, D-CA) on the Committee blocked the Pingree amendment. The Agriculture Committee bill adversely affects a wide range of social and conservation issues, including the protection of family farms, food security, environmental and public health, local and state authority, and judicial review, according to a cross-section of groups representing these interests. […]

(Beyond Pesticides, March 4, 2026) In the International Journal of Epidemiology, researchers from France assess the risks of kidney cancer with a wide range of agricultural activities and tasks, finding that occupational exposure heightens kidney cancer risk. In studying participants from the French AGRIculture and CANcer cohort (AGRICAN) with incident kidney cancer, elevated risks of disease development between 25-56% are documented for both men and women engaging in agricultural activities. In men, the authors find increased kidney cancer in those “working with rapeseed and sunflowers, and tasks related to other crops such as corn, wheat/barley, beet, and tobacco.” In women, an increased risk is noted for winegrowers and corn growers. “Pesticide use (on fields and/or seeds) was associated, for both sexes, with these crops, showing exposure-response relationships with crop area and work duration,” the researchers state. This study, of a large cohort of agricultural workers, highlights the disproportionate risks of adverse kidney health to farmworkers directly handling pesticides or encountering pesticide residues on recently treated products. According to the World Cancer Research Fund, kidney cancer is the 14th most common cancer worldwide, affecting men more often than women. Kidney cancer incidence and mortality have increased globally, with various causes, such […]

(Beyond Pesticides, March 3, 2026) Research published in Critical Reviews in Toxicology (CRT) and Proceedings of the National Academy of Sciences (PNAS) documents the genetic and epigenetic (changes to gene function without altering the DNA sequence) effects to pesticide-exposed groups through early-life exposure and from transgenerational inheritance (passed down through generations). These studies highlight the complex nature of mechanisms of toxicity, as well as the various pesticide exposure routes that begin even prior to conception. The analyses evaluate general and specific pesticide exposure as reported in observational and laboratory research. Through a systematic review and meta-analysis of studies on “DNA damage, cytogenetic damage, DNA methylation, or gene expression outcomes associated with prenatal and early childhood pesticide exposure,” the CRT authors link genotoxic mechanisms and epigenetic alterations to adverse health outcomes while the PNAS study shows pesticide-induced epigenetic alterations in mammals across 20 generations that “suggest the maternal and paternal lineages can both induce and inherit epigenetic alterations that influence disease (e.g., kidney, testis, ovary, prostate) incidence, reproductive health (e.g., parturition, infertility), and overall fitness generationally.” As the CRT study states: “One of the main ways pesticides can cause harm is through genotoxicity—their ability to damage genetic material. This damage can […]

(Beyond Pesticides, February 26, 2026) Published in PLOS ONE, research in Brazil “analyzed the impact of occupational/household chronic exposure to pesticides on the clinicopathological profile of breast cancer in rural women from Paraná southwest, a predominantly rural landscape with large pesticide uses,” finding that “pesticide exposure favors the occurrence of more aggressive breast cancer.” The study highlights the disproportionate risks of pesticides to farmworkers, focusing on women, as it compares exposed and unexposed populations and breast cancer tumor/disease characteristics. One of the study authors, Carolina Panis, PhD, discussed her earlier research at the Beyond Pesticides’ 42nd National Forum Series, The Pesticide Threat to Environmental Health: Advancing Holistic Solutions Aligned with Nature. In her previous work, Pesticide exposure and increased breast cancer risk in women population studies, Dr. Panis documents a number of pesticides that “can increase the risk of BC [breast cancer] development through various mutagenic [genetic mutations] and nonmutagenic mechanisms and can act directly as carcinogens or indirectly as biochemical modifiers and hormonal deregulators. The underlying mechanisms include endocrine disruption; genotoxicity; epigenetic changes [changes to gene function without changing DNA]; enhanced cell migration, invasion, and…” more. Dr. Panis and other researchers at the Forum support community-level understanding of the […]