(Beyond Pesticides, December 16, 2021) A study by Shanghai Jiao Tong University, China, finds Parkinson’s Disease (PD) risk increases with elevated levels of organochlorine (OCP) and organophosphate (OP) pesticides in blood. Among patients with PD, specific organochlorine compounds have greater associations with cognitive impairments, including depression and brain function. Research finds exposure to chemical toxicants, like pesticides, can cause neurotoxic effects or exacerbate preexisting chemical damage to the nervous system. Although the mechanism by which pesticides induce disease development remains unclear, researchers suggest changes in protein enzyme composition and cellular dysfunction from pesticide exposure interrupt normal brain function. Parkinson’s disease is the second most common neurodegenerative disease, with at least one million Americans living with PD and about 50,000 new diagnoses each year. The disease affects 50% more men than women, and individuals with PD have a variety of symptoms, including loss of muscle control and trembling, anxiety and depression, constipation and urinary difficulties, dementia, and sleep disturbances. Over time, symptoms intensify, but there is no current cure for this fatal disease. While only 10 to 15 percent of PD incidences are genetic, PD is quickly becoming the world’s fastest-growing brain disease. Therefore, research like this highlights the need to examine alternate […]

(Beyond Pesticides, December 2, 2021) A study published in Cellular Physiology and Biochemistry finds atrazine (ATR) exposure worsens lung disease outcomes in individuals with idiopathic (spontaneous) pulmonary fibrosis (IPF), a group of incurable lung diseases involving damaged/scarred lung tissue. Furthermore, chemotherapeutic products used to treat lymphoma (immune system cell cancer) like bleomycin can induce pulmonary fibrosis complications exacerbated by pesticide exposure. However, pesticide-related pulmonary fibrosis can have implications for neurological health, such as motor function. Scientific literature already finds an association between pesticide exposure and respiratory illnesses such as asthma, lung cancer, and chronic obstructive pulmonary disease (chronic bronchitis). Although IPF impacts over 5 million people a year globally, the disease is difficult to predict, which is concerning as the death rate is 50 to 56 percent within the first few years. Therefore, studies like this highlight the significance of evaluating how pesticide exposure impacts respiratory function, especially when exposure to respiratory toxicants increases vulnerability to existing respiratory-fixated illnesses like Covid-19. Advocate have urged the U.S. Environmental Protection (EPA) to incorporate scientific findings that these—where chemical exposures exacerbate an existing medical condition—into its pesticide registration review program. Researchers note, “[O]ur data represent an addition to the complex information on ATR-induced pulmonary toxicity. In particular, in this […]

(Beyond Pesticides, September 28, 2021) A widely used mosquito pesticide may exacerbate the effect of the Zika virus on fetal brain development, according to research published by an international team of scientists in the journal Environmental Pollution. Pyriproxyfen, an insect growth regulator often used as a mosquito larvicide, is registered for use in hundreds of commonly used pesticide products. But scientists have discovered that the pesticide’s mode of action has the potential to worsen the public health mosquito diseases the chemical aims to control. The research reinforces the extent of unknowns associated with synthetic pesticide exposure, underlining the need for a focus on nontoxic and ecological mosquito management. Scientists base their research on reports that in Brazil, during the 2015 Zika epidemic, certain areas of the country experienced higher rates of microcephaly. Microcephaly is a rare condition that causes pregnant women’s fetus to develop severe cranial deformities, alongside a range of other symptoms that include vision problems, hearing loss, feeding issues, developmental delays and seizures. The present study aimed to see how pyriproxyfen, used at higher rates in areas where microcephaly Zika cases were recorded, may interact with the virus. In an article published in The Conversation, researchers note that […]

(Beyond Pesticides, September 23, 2021) A study by Claremont Graduate University finds exposure to agricultural pesticides increases brain cancer risk up to 20 percent. This study expands on a 1998 study evaluating brain cancer risk among the farm population using epidemiologic studies. The etiology (cause) of brain cancer is inconclusive for many forms, including glioma and meningioma. Brain cancer risk factors include family history and exposure to radiation. However, geographical variance in brain cancer incidents suggests environmental pollutants like pesticides contribute to risk. Various research studies already note the adverse effects pesticide exposure has on the brain. These effects range from headaches and tumors to learning and developmental disabilities among children and adults. Although general cancer incidents are decreasing, brain and nervous system cancers are rising. Therefore, studies like this highlight the need to reevaluate pesticide exposure limits for those working with or around agricultural chemicals to prevent chronic, deadly diseases. The study researchers note, “This comprehensive review and meta-analysis encompassing 42 years of the epidemiologic literature and updating two previous meta-analyses by 20 years supports an association between farming and brain cancer incidence and mortality.[…]Our analyses suggest that the elevated risk has been consistent over time, and the addition of newer studies […]

(Beyond Pesticides, July 14, 2021) Corteva (formerly DowDupont) is facing a potential class-action lawsuit after several California families filed suit claiming that the use of the insecticide chlorpyrifos around their homes resulted in birth defects, brain damage, and developmental problems in their children. Chlorpyrifos is an organophosphate insecticide that has been linked to a range of health ailments, posing significant hazards particularly for pregnant mothers and their children. The lawsuits come as the U.S. Environmental Protection Agency (EPA) approaches a court-imposed 60-day deadline to decide the fate of the pesticide’s registration. Attorneys for the court cases, filed on behalf of individuals located in four California communities (Fresno, Kings, Medera, and Tulare counties), indicate they intend to pursue class-action status, which would allow additional injured parties to join the lawsuit. The plaintiffs argue that the effects of chlorpyrifos exposure lingers in the agricultural communities where they reside. “We have found it in the houses, we have found it in carpet, in upholstered furniture, we found it in a teddy bear, and we found it on the walls and surfaces,” said Stuart Calwell, lead attorney for the plantiffs. “Then a little child picks up a teddy bear and holds on to it.” […]

(Beyond Pesticides, May 19, 2021) Last week Health Canada quietly announced its intent to cancel all remaining registrations of the brain-damaging insecticide chlorpyrifos. The decision by Canada’s federal pesticide regulators comes shortly after a U.S. federal court gave the U.S. Environmental Protection Agency (EPA) a 60-day deadline to make a final decision on whether to amend or cancel the chemical’s registration. With Europe and now Canada eliminating use of this hazardous insecticide, advocates are urging that the Biden Administration, under EPA administrator Michael Regan, finally puts an end to the decades of harm caused after chlorpyrifos was first registered in 1965. Up until recently, Canada and the U.S. had relatively similar provisions regulating chlorpyrifos use. Officials in both countries eliminated homeowner use, and tightened up on agricultural uses in the 2000s and early 2010s, requiring additional personal protective equipment and drift mitigation measures. However,  Health Canada  began to look at significant restrictions on chlorpyrifos in 2019, when it proposed eliminating a range of uses that threaten environmental health. Under its draft decision, regulators planned to eliminate all uses except for mosquito control, structural pest control, outdoor ornamentals, and greenhouse ornamentals. Certain agricultural uses were provided an extended phase-out period with […]

(Beyond Pesticides, May 17, 2021) The U.S. Environmental Protection Agency (EPA) has less than two months to decide whether to cancel or modify its registration of the brain-damaging organophosphate insecticide chlorpyrifos, following a decision from a federal appeals court. The ruling comes after more than a decade of delay from the federal agency tasked with protecting public health and the environment from the hazards of chemicals like chlorpyrifos. The decision now falls to the Biden Administration’s EPA Administrator Michael Regan, after the previous administration reversed a proposal to ban agricultural uses of chlorpyrifos in 2017. Most residential uses of the chemical were banned in 2000.  Tell EPA to ban chlorpyrifos and other neurotoxic pesticides. The target of action by which chlorpyrifos and many other pesticides kill is the nervous system. It is not surprising, then, that pesticides also target the nervous system in humans. They are particularly hazardous to children, who take in greater amounts of pesticides relative to their body weight than adults, and whose developing organ systems are typically more sensitive to toxic exposures. The body of evidence in the scientific literature shows that pesticide exposure can adversely affect a child’s neurological, respiratory, immune, and endocrine systems, even at […]

(Beyond Pesticides, April 29, 2021) Glyphosate-based herbicides (GBHs) are incompatible with sustainable agriculture goals, according to a recent scientific literature analysis by scientists at Tufts University, Massachusetts. Glyphosate is the most commonly used pesticide active ingredient worldwide, appearing in many herbicide formulas, including Bayer’s (formerly Monsanto) RoundupTM. The use of this chemical has been increasing since the inception of crops genetically modified to tolerate glyphosate. However, studies demonstrate glyphosate is the main contributor to human, biotic, and ecosystem harms as toxicities from herbicides are now double what it was in 2004.  The National Academy of Sciences identifies four goals of sustainable agriculture—productivity, economics, environment, and social well-being for future generations. However, pesticides like glyphosate are ubiquitous in the environment, putting the health, economy, and food/resources for future generations at risk. Therefore, research like this is vital for understanding how chemical use can undermine sustainable agriculture goals to protect humans, animals, and environmental health. Researchers note, “[W]hether or not GBHs are viewed as essential or unessential to contemporary agriculture, and notwithstanding their role in non-tillage agriculture, this study shows that glyphosate-based herbicides do not reach the bar of agricultural sustainability, with respect to humans and the environment, making the system they are part of unsustainable.” Researchers thoroughly examined […]

(Santa Fe, New Mexico, February 11, 2021)—New Mexico State Senator Brenda McKenna  introduced the Public Schools Pesticide Management Act (PSPMA) (SB 326) in order to protect school children from exposure to toxic pesticides where they learn and play. The legislation advances ecological pest management, an environmentally healthy way to protect children and the public from weeds and pests, within all schools, classrooms, community parks, and playgrounds in the state. Under PSPMA, only organic and minimum risk pesticides, the least toxic, yet still-effective products on the market will be allowed. Toxic pesticide use will be permitted only under a defined public health emergency, as determined by a public health official. The law does not address the use of pesticides in farming or agriculture.  “All children in New Mexico have the right to a safe environment where they learn and play,” said State Senator Brenda McKenna. “This legislation embraces an environmentally healthy approach to pest management, so families do not have to worry about the use of toxic pesticides in schools and communities.” Pesticide exposure presents unique dangers to children’s health. Children’s developing organ systems are less able to detoxify harmful chemicals, and they often come into closer contact with pesticides than adults in […]

(Beyond Pesticides, November 25, 2020) New research from the Centre for Environment and Occupational Health Research at the University of Cape Town (UCT), South Africa, finds a link between pesticide exposure and adverse neurological symptoms among children and adolescents living in agricultural areas. Considering the etiology (cause) of many brain and neurological disorders are unknown, research like this is significant for understanding how pesticide exposure promotes disease development, especially among vulnerable populations. Researcher notes, “Children who indicate activities related to pesticide exposure may be at higher risk for developing headaches and lower cognitive performance in the domains of attention, memory and processing speed. […]Given [the] history and socio-economic divide to the farm laborers, […]future interventions should aim to reduce the health risks of these vulnerable populations, including their children.” The study demonstrates that there is a relationship between pesticide exposure from various farm-related and leisure activities and headaches and neurocognitive functioning (i.e., autism, attention deficit hyperactivity disorder (ADHD), lower intelligence (IQ), and harmful social behavior and behavioral regulation) in children and adolescents. To assess which farm-related/leisure activities concerning pesticide exposure cause cognitive symptoms, researchers administered a questionnaire addressing child pesticide handling, direct consumption of field crops, interaction with field adjacent water sources, […]

(Beyond Pesticides, July 10, 2020) A study published in June 2020 in Environmental Health journal is especially concerning for people who become, or plan to become, pregnant. It concludes that personal, agricultural, and household exposures to pesticides may increase the risk of a relatively rare fetal disorder called “holoprosencephaly.” The study finds that pre-conception and the first few weeks of pregnancy are the most vulnerable periods during which exposure can increase risk of this disorder, in which the embryo’s forebrain fails to develop into two distinct hemispheres. The study’s results reinforce Beyond Pesticide’s long-standing warnings of the dangers of pesticides to children and the necessity of shifting to a precautionary approach to the introduction and use of synthetic pesticides (and other chemicals) across all sectors. The importance of this shift is perhaps no more poignantly illustrated than in the impacts that pesticide exposure can have on new life. The study, conducted from 2016 through 2019 by researchers from NIH (the U.S. National Institutes of Health) and the University of Wisconsin–Madison, is a case-control study — one that compares subjects who have a disease or disorder with “controls” who do not have the disorder, comparing the frequency of exposure to a particular risk […]

(Beyond Pesticides, May 7, 2020) On April 22, 2020, the Ninth Circuit U.S. Court of Appeals granted the U.S. Environmental Protection Agency (EPA) 90 days to respond to Natural Resources Defense Council’s (NRDC) petition requesting cancellation of tetrachlorvinphos (TCVP), a toxic organophosphate pesticide in pet products. The order followed the Ninth Circuit’s decision to grant NRDC’s petition for a writ of mandamus (a court’s order requiring a lower court or public authority to perform its statutory duty) as EPA withheld action to fulfill NRDC’s judicial review of TCVP, for over a decade. A favorable ruling on NRDC’s mandamus petition can influence other petitioners that hope to coerce agency action, especially when public health is at risk. The court states, “Repeatedly, the EPA has kicked the can down the road and betrayed its prior assurances of timely action, even as it has acknowledged that the pesticide poses widespread, serious risks to the neurodevelopmental health of children.” NRDC petitioned EPA to cancel TCVP pesticide registration under the Federal Insecticide, Fungicide, and Rodenticide Act (FIFRA) in April 2009, after studies indicated humans absorb TCVP through contact with pesticide-treated pet products. EPA failed to respond to the initial petition after five years, and NRDC filed a 2014 mandamus requiring […]

(Beyond Pesticides, March 24, 2020) Last week, Maryland became the latest state to prohibit use of the brain-damaging insecticide chlorpyrifos, after a measure cleared both the state Senate and House. Although the legislation implements a limited ban that sunsets after four years, advocates consider this action a step in the right direction that will protect the health and safety of Maryland residents. “Even amidst our current public health crisis, the Maryland legislature acted to protect all Marylanders’ health for years to come by banning this toxic pesticide, and we are so grateful,” said Ruth Berlin, Executive Director of the Maryland Pesticide Education Network to WBOC. Chlorpyrifos is an organophosphate insecticide known to inhibit the proper nerve functioning by affecting the enzyme acetylcholine esterase. The impacts of this pesticide are particularly concerning for young children, as research finds that children exposed to high levels of chlorpyrifos had mental development delays, attention problems, attention-deficit/hyperactivity disorder problems, and pervasive developmental disorder problems at three years of age. While Maryland is the fourth state to restrict the use of chlorpyrifos, it is the second to implement these restrictions through legislation. In California, the state Department of Pesticide Regulation is implementing a phase out of […]

(Beyond Pesticides, February 12, 2020) Corteva, a company spun-off from DowDupont, will stop producing chlorpyrifos by the end of this year as a result of declining sales. Despite the move being in the interest of public health, the company is earning little praise from health advocates for what amounts to simply a shrewd financial decision. As news articles on the announcement have noted, Corteva will continue to support Environmental Protection Agency (EPA) registration of chlorpyrifos, which allows generic manufacturers to continue to sell this brain-damaging chemical. “Other people are going to continue to profit from harming children,” said Marisa Ordonia, an attorney with the group EarthJustice to Canada’s National Observer. “It is big that such a major player is saying no, we’re not going to do this any more. It’s a great signal that people don’t want brain-damaging pesticides on their food. But we’re going to continue to keep fighting to make sure children and farmworkers are protected.” At odds is the difference between halting production of chlorpyrifos and cancelling its EPA registration. While Corteva has the ability to voluntarily stop producing its own product, EPA registration permits other generic manufacturers to continue to producing the product. And, over the […]

(Beyond Pesticides, August 30, 2019) The indictment of organophosphate pesticides gained more traction with the publication, in the Proceedings of the National Academy of Sciences, of a new research study out of the University of California, Berkeley. The research, among the first to use advanced brain imaging to assess cortical activation, shows altered brain activity, during tasks that call on executive function, in teenagers from California’s Salinas Valley (the site of significant organophosphate use) whose mothers were exposed prenatally. The UC Berkeley study underscores the slow-motion calamity of the Trump administration Environmental Protection Agency’s (EPA’s) failure to ban the use of this class of pesticides, and of chlorpyrifos in particular, which compounds carry extreme risks for children. The effects of this prenatal exposure continue to unfold during children’s critical developmental periods. Researchers used fNIRS (functional near-infrared spectroscopy) imaging to monitor blood flow in the brains of the teens, 15–17, born and raised in the Salinas Valley. They used data from the California Pesticide Use Reporting program (which documents locations and times of pesticide spraying) to estimate the subjects’ mothers’ proximity to organophosphate (OP) applications during pregnancy. The subject adolescents — estimated to have relatively high levels of prenatal exposure to organophosphates — […]

(Beyond Pesticides, July 22, 2019) The U.S. Environmental Protection Agency (EPA) will permit the continued use of a known neurotoxic insecticide on the food the Americans eat, the agency announced yesterday in response to a lawsuit filed by public health groups. Health advocates say the move to continue chlorpyrifos use is the latest example of the agency working to protect the profits of industry over the health of Americans. “By allowing chlorpyrifos to stay in our fruits and vegetables, Trump’s EPA is breaking the law and neglecting the overwhelming scientific evidence that this pesticide harms children’s brains,” said Patti Goldman, an attorney for Earthjustice. “It is a tragedy that this administration sides with corporations instead of children’s health.” Under a lawsuit filed in the 9th Circuit US Court of Appeals, EPA had 90 days to provide a justification for why the pesticide should remain on the market. EPA denied the petition yesterday, and rather than providing positive justification for continued use of the chemical, attacked the sound science claimants urged the agency to consider as “not…valid, complete, and reliable.” In the absence of EPA action, several states are leading in the protection of their residents by rejecting the agency’s determination regarding […]

(Beyond Pesticides, May 20, 2019) The bans of chlorpyrifos in three important agricultural states show the support for a ban of the chemical nationwide. Hawai’i banned chlorpyrifos a year ago with a unanimous vote of the legislature. New York and California banned it this month. States have been pursuing bans since the Environmental Protection Agency rescinded its proposed ban in 2017. Tell Your Governor to Ban Neurotoxic Pesticides and Support Organic; Send Thanks to Your Governor in Hawai’i, New York, and California Like other organophosphate pesticides, chlorpyrifos has been linked to damaging and often irreversible health outcomes in workers, pregnant women, and children. A widely used pesticide, agriculture companies annually spray six million pounds on crops like citrus, apples, and cherries.  In the same family as Sarin gas, the substance was initially developed prior to World War II as a chemical weapon. It can overstimulate the nervous system to cause nausea, dizziness, and confusion. With very high exposures (accidents or spills), it can cause respiratory paralysis and even death. When applying the chemical to fields, workers must wear protective garments such as respirators. Workers are then blocked from entering the fields from 24 hours up to 5 days after application due to the chemical exposure risk. A group of leading toxics […]

(Beyond Pesticides, May, 7, 2019) Last week, the New York State legislature voted to phase out and eventually ban the use of the neurotoxic insecticide chlorpyrifos. The vote, 44-18 in the state Senate and 94-50 in the Assembly, is still awaiting the Governor’s signature, who is expected to sign the measure. As evidence of harm continues to accumulate, scientists have called for a ban, and a legal case works its way through the courts, pressure is mounting on the U.S. Environmental Protection Agency (EPA) to once and for all remove this harmful pesticide from use. New York’s legislation sets implementation dates that leapfrog a similar law banning chlorpyrifos that passed in Hawai’i last year. Although Hawai’i’s law takes effect beginning in July of this year, the state may provide temporary use permits for the chemical until December 2022. New York also phases in restrictions, first prohibiting aerial applications beginning January 2020, then prohibiting all use except on apple trees starting January 2021. The chemical will be completely banned for use in New York in December 2021. Chlorpyrifos is a highly toxic insecticide that has been linked to damaging and often irreversible health outcomes, particularly for pregnant mothers and their children, […]

(Beyond Pesticides, January 22, 2019) Earlier this month, U.S. Representative Nydia Velásquez (D-NY) introduced The Ban Toxic Pesticides Act, H.R.230 which bans the insecticide chlorpyrifos from commerce. Chlorpyrifos is a toxic chemical that has been linked to damaging and often irreversible health outcomes in workers, pregnant women, and children. As a result of a revised human health risk assessment, the Environmental Protection Agency (EPA) developed a regulation to ban chlorpyrifos in 2016. Under the Trump Administration, the EPA has taken steps to reverse the regulation. “It’s unconscionable for EPA to turn a blind eye as children and workers are exposed to this poison,” Velázquez said.  “If the EPA won’t do its job when it comes to chlorpyrifos, then Congress needs to act – and do so quickly.” Ask your U.S. Representative to Co-Sponsor H.R. 230 to Stop the Use of the Toxic Insecticide Chlorpyrifos, which Is Damaging Children’s Brains.  Chlorypyrifos is a widely used pesticide. Agriculture companies annually spray 6 million pounds of the substance on crops like citrus, apples, and cherries.  In the same family as Sarin gas, the substance was initially developed prior to World War II as a chemical weapon. It can overstimulate the nervous system to cause […]

(Beyond Pesticides, December 4, 2018) In mid-November, the state whose agricultural operations used more than 900,000 pounds of chlorpyrifos in 2016 (down from two million pounds in 2005) moved to establish some temporary restrictions on its use. Regulators at the California Department of Pesticide Regulation (CDPR) issued interim restrictions on the compound while the agency works on a formal regulatory process to list chlorpyrifos as a “toxic air contaminant” and develop permanent restrictions on its use. A neurological toxicant, chlorpyrifos damages the brains of young children: impacts of exposure, even at very low levels, include decreased cognitive function, lowered IQ, attention deficit disorder, and developmental and learning delays. It was slated to be banned for food uses by the U.S. Environmental Protection Agency (EPA) last year, but the decision was reversed by the Trump administration. The interim measures in California include: banning aerial application of chlorpyrifos; ending its use on many crops — except for those determined to be “critical” by virtue of there being few, if any, alternatives (as determined by the University of California Cooperative Extension and listed on DPR’s website); establishing a quarter-mile buffer zone for 24 hours after any application of the pesticide; and requiring a 24/7/365, 150-foot […]

(Beyond Pesticides, November 20, 2018) Scientific conclusions used to support the registration of the insecticide chlorpyrifos were flawed and omitted key health impacts, according to a fresh analysis of the original data by a team of independent scientists from northern Europe and the U.S. This re-review not only casts further doubt on the safety of the neurotoxic chlorpyrifos, it highlights a major flaw within federal pesticide regulation that allows pesticide producers to submit their own safety evaluations to the U.S. Environmental Protection Agency without public oversight. “One conclusion we draw is that there is a risk that the results of industry-funded toxicity tests are not reported correctly,” says co-author Axel Mie, PhD. “This makes it difficult for the authorities to evaluate the pesticides in a safe and valid way.” In both the U.S. and European Union, pesticide producers contract with laboratories to perform required safety tests of active ingredients they hope to register for use. While these studies are generally considered ‘confidential business information’ and not available to the public, using Swedish freedom of information laws, researchers were able to obtain two key studies relating to the developmental neurotoxicity of chlorpyrifos. Although not disclosed within the study, it is well […]