13
Nov
(Beyond Pesticides, November 13, 2025) A study in Environmental Science & Technology shows that maternal exposure to organophosphate (OP) and pyrethroid insecticides adversely affects newborn health. Through amino acid and acylcarnitine metabolomics (the study of small molecules known as metabolites) with over 400 mother-infant pairs, this research analyzes metabolic pathways linking pesticide exposure to negative birth outcomes. “To our knowledge, this study is the first to reveal the effect of OP and pyrethroid insecticide exposure on neonatal metabolic signatures, which may elucidate a key role of metabolites in insecticide exposure and birth outcomes,†the authors state. In collecting maternal urine samples in the first and third trimesters, as well as neonatal blood samples after birth, OP and pyrethroid metabolites and metabolomic biomarkers are assessed. Notably, the authors report: “Results indicated that third-trimester maternal urinary levels of 3- phenoxybenzoic acid (3-PBA) and diethyl dithiophosphate (DEDTP) were negatively associated with birth weight. Specifically, a one-unit increase in their ln-transformed [natural logarithm form] concentrations was associated with a 1.508% decrease in birth weight for 3-PBA and a 1.366% decrease for DEDTP.†Additionally, the analyses show that OP and pyrethroid exposure is associated with “disrupted neonatal amino acids and acylcarnitine profiles, with patterns varying […]
Posted in Agriculture, Biomonitoring, Children, Chlorpyrifos, Cyfluthrin, Developmental Disorders, Flumethrin, Metabolism, Metabolites, organophosphate, pyrethroids, Synthetic Pyrethroid | No Comments »
01
Oct
(Beyond Pesticides, October 1, 2025) A novel study in Scientific Reports combines computational analyses with toxicological data to identify pathways affected by exposure to the weed killer glyphosate. The analyses identify glyphosate targets that correlate with kidney injury and kidney cancer, revealing pathways with significant glyphosate-induced alterations, including the dysregulation of nitrogen metabolism that leads to ammonia accumulation and oxidative stress, both of which contribute to renal (kidney) damage and carcinogenesis (development of cancer). “This study provides a comprehensive investigation into the molecular mechanisms by which glyphosate may contribute to kidney injury and kidney cancer, employing an array of bioinformatics tools for target prediction, toxicity assessment, pathway enrichment analysis, molecular docking and molecular dynamics simulation,†the researchers state. The results of the analyses and simulations highlight the molecular mechanisms underlying glyphosate’s nephrotoxic (damaging to kidneys) and carcinogenic (cancer-causing) effects. Study Importance and Background Glyphosate, known as a broad-spectrum systemic herbicide, has been used for agricultural and nonagricultural purposes for decades and is the most extensively used herbicide worldwide. This widespread use is largely due to its application to genetically engineered, glyphosate-tolerant crops. Both glyphosate and its main metabolite (breakdown product), aminomethylphosphonic acid (AMPA), are detected in water, soil, and food, […]
Posted in Agriculture, aminomethylphosphonic acid (AMPA), Cancer, Glyphosate, Herbicides, Kidney Damage, Metabolism, Oxidative Stress | No Comments »
