(Beyond Pesticides, August 8, 2024) With the use of its emergency authority—not used in nearly 40 years, the U.S. Environmental Protection Agency (EPA) on August 7 banned a pesticide (the weed killer Dacthal or DCPA—dimethyl tetrachloroterephthalate) under the “imminent hazard” clause of the federal pesticide law. At the same time, the agency is exercising its authority to prohibit the continued use of Dacthal’s existing stocks, a provision that EPA rarely uses. EPA identified serious concerns about fetal hormone disruption and resulting “low birth weight and irreversible and life-long impacts to children [impaired brain development, decreased IQ, and impaired motor skills] exposed in-utero” and finds that there are no “practicable mitigation measures” to protect against these hazards. The last time EPA issued an emergency action like this was in 1979 when the agency acknowledged miscarriages associated with the forestry use of the herbicide 2,4,5-T—one-half of the chemical weed killer Agent Orange, sprayed over people to defoliate the landscape of Vietnam in the war there—with the most potent form of dioxin, TCDD (2,3,7,8-Tetrachlorodibenzo-p-dioxin). While EPA has been congratulated for using its emergency authority, which it is obviously reluctant to use, and health and environmental activists say could be used broadly, the timeline […]

(Beyond Pesticides, August 2, 2024) In a recent study published in Science, a team from the University of Massachusetts and Yale University provides quantitative insight into the significant effects of a recent U.S. Supreme Court decision on the nation’s water quality. This research highlights the essential role of ephemeral streams—water sources that flow temporarily after rainfall—in transporting pollutants, including pesticides, sediments, and nutrients from land to larger water bodies.  This comprehensive study underscores the devastating risk to U.S. water quality, stemming from the May 2023 U.S. Supreme Court decision, Sackett v. Environmental Protection Agency (EPA), which dramatically limits the agency’s ability to protect ephemeral streams as well as critical wetland ecosystems under the Clean Water Act (CWA).  As a May 2024 report by Clean Water for All Coalition notes, “The [Sackett] decision has endangered the drinking water sources of at least 117 million Americans by stripping protections from over half of the nation’s wetlands, as well as up to nearly 5 million miles of rain-dependent and seasonal streams that feed into rivers, lakes, and estuaries.” At a time when an immediate response to the climate crisis and chemical pollution is more urgent than ever, the U.S. Supreme Court’s judicial decisions are seen […]

(Beyond Pesticides, July 31, 2024) The latest commentary on “forever chemicals” in Environmental Health Perspectives captures growing concerns for the class of per- and polyfluoroalkyl substances (PFAS) that are found in pesticide products and cause persistent contamination that threaten human health and the environment. The authors share, “Given that pesticides are some of the most widely distributed pollutants across the world, the legacy impacts of PFAS addition into pesticide products could be widespread and have wide-ranging implications on agriculture and food and water contamination.” Fluorination, which adds fluorine to a compound, is used to modify properties, such as the stability of chemicals. It can also increase residual activity of pesticide ingredients. Fluorinated molecules, including PFAS, are “a serious environmental health concern owing to their highly persistent nature, often potent toxicities, potential to bioaccumulate, and widespread presence in people, animals, and the broader environment,” the authors state. They continue in saying, “The long-term impacts of using mixtures of extremely persistent chemicals on potentially hundreds of millions of acres of US land every year is, to us, a cause for concern.” The commentary, titled “Forever Pesticides: A Growing Source of PFAS Contamination in the Environment,” explores how and to what extent PFAS […]

(Beyond Pesticides, July 26, 2024) Beyond Pesticides released the latest issue of Pesticides and You this week, a compendium of scientific research on pesticide threats to human and environmental health. The issue is a breathtaking warning from the science community that environmental, health, and labor laws are not protecting the public. Beyond Pesticides says in its introduction that a shift away from toxic pesticide use is urgently needed. Included in this issue are scientific reviews of research reported by Beyond Pesticides in 2023, providing a critique of the independent peer-reviewed literature with a shocking range of adverse effects, including cancer, neurotoxicity, brain effects, reproductive impacts, diabetes and obesity, chronic kidney and liver disease, Parkinson’s, respiratory illness and asthma, learning and behavioral abnormalities, and more, as well as disproportionate harm to people of color. In addition, the science documents pesticides’ catastrophic harm to the ecosystems that sustain life. In total, these dramatic findings call for an end to the use of toxic pesticides, incompatible with respect for living organisms and, to environmental, health, and labor advocates, unconscionable given the availability of viable, cost-effective organic practices. This issue adds to the body of knowledge from two previous issues of Pesticides and You (Transformative Change: […]

(Beyond Pesticides, July 25, 2024) On July 10, the Oregon Court of Appeals ruled that the Federal Insecticide, Fungicide and Rodenticide Act (FIFRA) does not preempt pesticide exposure victims’ state law claims against pesticide manufacturers, based on reporting from The New Lede. This decision builds on years of judicial precedent from the Supreme Court of the United States (SCOTUS) that protects individuals’ right to use failure-to-warn claims against producers of toxic pesticides, including Bayer-Monsanto. The importance of judicial review is critical to protecting the public against public health impacts of toxic pesticide use in the context of last month’s SCOTUS decision ending Chevron Doctrine, and with it the end of deferring to federal regulatory agencies on ambiguities in statutory mandates. A growing coalition of environmental and public health advocates, organic farmers, trial attorneys, farmworkers, and physicians are united in pushing back against a concerted effort by industry and its allies to attack victims’ ability to sue under “failure-to-warn” through the Farm Bill, state legislatures, and the proposed federal budget for Fiscal Year 2025. Oregon Court of Appeals In 2022, a local trial court in Oregon ruled in favor of Monsanto on a lawsuit initiated by Jackson County residents Larry and […]

(Beyond Pesticides, July 24, 2024) The Center for Food Safety—joined by environmental, farm, and grassroots organizations including Beyond Pesticides—submitted a groundbreaking petition yesterday to the U.S. Environmental Protection Agency (EPA), urging immediate action to address the presence of per- and polyfluoroalkyl substances (PFAS) in pesticides and pesticide containers. Numerous studies have shown that the broad use of PFAS chemicals, and the resulting environmental contamination, has devastating impacts on public health, wildlife, and pollinators. Despite acknowledging PFAS as an urgent public health and environmental issue, EPA has upheld hundreds of registrations of pesticide ingredients that fall into the PFAS category. Furthermore, EPA has allowed the ongoing use of fluorinated pesticide storage containers, despite the agency itself finding that these containers leach PFAS chemicals into pesticide products.   PFAS, known as “forever chemicals” due to their ability to persist in the environment, are endocrine disruptors, which are linked to developmental issues, cancers, and organ damage. Crops can uptake PFAS from soil, resulting in dietary exposure for both the public and wildlife, while PFAS ingredients in pesticides can also leach into groundwater, contributing to widespread PFAS drinking water contamination. In recent years, EPA has acknowledged this critical issue and committed to addressing PFAS contamination outside […]

(Beyond Pesticides, July 18, 2024) A recent study in The Journal of Toxicological Sciences shows that a single dose of the neonicotinoid insecticide clothianidin (CLO) induces behavioral abnormalities, predominantly in female mice, throughout key stages of development. In testing mice at various ages, sex-specific changes were identified that highlight not only varied effects on males and females but also how pesticide exposure at a young age can cause lasting impacts throughout adulthood in mammalian species.  The researchers, at the Laboratory of Animal Reproduction and Development at Tohoku University in Japan, “utilized murine [mouse] models to compare the sex-specific differences in behavioral effects following CLO exposure at different developmental stages. [They] orally administered CLO to male and female mice as a single high-dose solution (80 mg/kg) during the postnatal period (2-week-old), adolescence (6-week-old), or maturity (10-week-old), and subsequently evaluated higher brain function.”   As the authors remark, “Most studies on the neurotoxicity of CLO have targeted only males, with limited insights regarding the neurodevelopmental toxicity in females. There are significant sex differences in brain development due to hormonal, genetic, epigenetic, and other sex-specific factors. Moreover, there are also a number of sex-based differences in the prevalence of developmental disorders, such as […]

(Beyond Pesticides, July 16, 2024) Yet another study in the August 2024 journal Ecotoxicology and Environmental Safety has found that exposure to organophosphorus pesticides (OPPs) is correlated with increased suicidal thoughts in some people. This study is just the latest in a long line of studies from around the world that have linked pesticide exposure to mental health conditions, including sleep disorders, depression, and suicidal ideation (SI). As the rate of suicide increased by 30% between 2000 and 2020, there is an urgent public health need to investigate and address all potential contributing factors. A 2019 study, covered in Daily News, found that teens and adolescents living in agricultural areas and exposed to organophosphate (OP) insecticides are at higher risk of depression, In July and January this year, other studies link farmer psychiatric episodes to pesticide exposure, adding to the body of science. Exposure to household pesticides is also linked to depression in a 2020 study.   Study and Methodology  The study entitled “Association between exposure to organophosphorus pesticide and suicidal ideation among U.S. adults: A population-based study,” analyzes information on the mental and physical health of over 5,000 individuals aged 20 and up in the United States. The study aims […]

(Beyond Pesticides, July 9, 2024) Last month, California cannabis regulators recalled a pesticide-tainted vape, one of the contaminated products identified in a Los Angeles Times investigation. The report reveals that the California Department of Cannabis Control (DCC) has for months been aware of the presence of dangerous chemicals in legal cannabis sold to the public. Conducted by Los Angeles Times and WeedWeek, a cannabis industry newsletter, the investigation has uncovered alarming levels of the insecticide chlorfenapyr in legal cannabis products sold in state dispensaries. According to an article via the National Institutes of Health, “Although [chlorfenapyr] has been identified as a moderately toxic pesticide by the World Health Organization (WHO), the mortality rate of poisoned patients is extremely high. There is no specific antidote for chlorfenapyr poisoning.” The chemical is associated with adverse liver effects and is toxic to bees, birds, and aquatic organisms. Despite claims that the state’s cannabis is safe and regulated, many popular brands of vapes and pre-rolled joints were found to contain dangerous pesticides at levels exceeding state limits and federal standards for tobacco. This investigation comes on the heels of the discovery of large amounts of illegal Chinese pesticides at cannabis grow operations around the state. […]

(Beyond Pesticides, July 2, 2024) Men’s Mental Health Awareness Month, which took place last month, evokes concern about the growing body of science linking pesticide exposure to neurological effects linked to depression. Recent studies reveal elevated rates of psychiatric disorders, including suicide, among farmers, with problems more common for males.  Through systematic reviews, meta-analyses, surveys and interviews, and blood sampling, these three studies add to the growing body of science linking pesticide exposure to neurological impacts. First, in the Journal of Agromedicine, researchers from Greece and the United Kingdom review eight studies and find a significant positive association between pesticide poisoning and depression in agricultural populations.1 Second, a study in Toxicology shows a link between depression in Brazilian farmers and pesticide exposure, most notably with glyphosate usage.2 Third, the latest study in Environmental Toxicology and Pharmacology focuses on work by researchers from Spain in identifying farmers exposed to chlorpyrifos, mancozeb, and malathion that have higher rates of depressive symptoms and suicide attempts.3  Through a meta-analysis of published research, the authors of the Agromedicine journal article identify pesticide poisoning as a risk factor of depression. With depression affecting more than 264 million individuals worldwide, this is a field of interest with […]

(Beyond Pesticides, June 27, 2024) Earlier this month, Public Employees for Environmental Responsibility (PEER) filed a lawsuit against the U.S. Environmental Protection Agency (EPA) on behalf of a group of ranchers and farmers in Texas harmed by biosolids contaminated with per- and polyfluoroalkyl substances (PFAS). The plaintiffs charge that their health and livelihoods were severely damaged due to contaminated biosolids leaching from neighboring properties onto their land. Despite EPA’s responsibility under the Clean Water Act (Section 405(d) and 40 CFR Part 503) to identify toxic pollutants in biosolids and regulate them to protect human health and the environment, the agency has not effectively addressed the dangers posed by PFAS in biosolid fertilizers. EPA’s failure has dramatic impacts on farmers as well as the public, who are eating or drinking PFAS-contaminated crops, dairy milk, beef, or other meat products. The shortcomings of federal regulations underscore the urgent need for a shift in how federal and state agencies approach these issues, prioritizing precaution to prevent future harm. The persistence of these legacy or “forever” chemicals in the environment illustrates the severe consequences of a historically lax regulatory framework in the U.S.  The National Association of State Departments of Agriculture (NASDA) has identified […]

(Beyond Pesticides, June 21, 2024) A recent review of the scientific literature, published in Science of The Total Environment, analyzes multiple species of bees on a molecular level to better understand the poisoning mechanisms that could, as the authors see it, inform chemical risk assessments with more precision. The mechanisms “implicated in the tolerance of bees to specific pesticides, and thus as determinants of insecticide sensitivity, … include metabolic detoxification, insecticide target proteins, the insect cuticle and bee gut microbiota,” the authors write. This review references more than 90 studies performed over the last 30+ years, with most being published in the last 5-10 years, as the understanding and importance of molecular determinants of bee sensitivity has emerged. Pollinators, such as bees, provide crucial ecosystem services by pollinating both wild plants and essential crops. The exposure these insects are subjected to threatens their existence, which occurs through pesticide contamination that can lead to impacts on growth and development or even colony collapse.    “While bees have only been exposed to human-made pesticides over the recent past (last 80 years) they have co-evolved with plants and fungi which produce a range of xenobiotics, including plant allelochemicals and mycotoxins,” the authors state. […]

Calls for Holistic Environmental Justice and a Shift Away from Societal Dependence on Petrochemical Pesticides and Fertilizers (Beyond Pesticides, June 18-19, 2024) Juneteenth (June 19) commemorates the date in 1865 when the enslavement of Black Americans ended in the westernmost Confederate state of Texas, over two and a half years after the Emancipation Proclamation of 1863 and the defeat of the Confederacy on April 9, 1865. On June 19, 1865, Union Major General Gordon Granger brought federal troops to Galveston, Texas and finally, and belatedly, implemented the Emancipation Proclamation, which proclaimed on January 1, 1863 freedom from slavery across the nation. Carl Mack, PhD, a historian and former President of the Seattle-King County NAACP, reminds us that there were still 225,000 enslaved Black Americans in Kentucky and Delaware after June 19, 1865 and the end of the Civil War until December 6, 1865 when Georgia became the 27th state to ratify the 13th amendment. “That is the day in which Georgia ratified the 13th amendment,” Dr. Mack goes on to discuss the remaining three former border states on their progress in adopting the 13th amendment. “As it applies to Delaware and Kentucky, Delaware did not ratify the 13th amendment until […]

(Beyond Pesticides, June 11, 2024) Published in Science of The Total Environment in May, a comprehensive literature review of population-based studies finds strong linkages between direct and acute pesticide exposure and elevated risk of breast cancer (BC). A majority of the studies analyzed in this review were based on population groups in the United States, but also extends to Australia and three European countries (Greece, France, and Italy). Included in these studies are women who worked in chemical-intensive agricultural settings, directly sprayed pesticides in their at-home gardens, and/or handled pesticide-contaminated clothing. The findings in this literature review underscore organic advocates’ concerns of relying on pesticide substitution models that inevitably impact the health of land stewards, farmers, farmworkers, and the broader public rather than transforming food systems to an organic model that bans the use of toxic petrochemical-based pesticides. The goal of this review was to synthesize existing literature on pesticide exposure and breast cancer to determine the specific pathways and underlying mechanisms that contribute to female participants’ heightened risk. This literature review was published online by researchers at the University of Arizona’s R. Ken Coit College of Pharmacy and Coit Center for Longevity and Neurotherapeutics and the Laboratory of Tumor […]

(Beyond Pesticides, June 5, 2024) Individuals living near chemical-intensive agricultural environments have heightened risk of Alzheimer’s disease relative to the general population, according to a study published earlier this year in Psychiatry Research. This finding builds on existing peer-reviewed studies that document the relationship between chronic pesticide exposure and elevated risk of neurodegenerative disorders including Alzheimer’s disease, as well as Parkinson’s disease, dementia, multiple sclerosis (MS), and Huntington’s disease. In light of the mountains of scientific evidence, advocates continue to demand for a wholesale transformation of agricultural and land management systems to one based in organic principles in alignment with the U.S. National Organic Program. Study Analysis This study was published online on May 1, 2024 with the full entry to be published in July 2024. The researchers are physicians, health professionals, and professors at the University of Almeria in southern Spain, specifically working in the Health Research Center and the Department of Nursing, Physiotherapy and Medicine. There is also a researcher, Cristofer Ruiz-González, who works at the Torrecárdenas University Hospital also located in Almeria, Spain. Researchers gathered case information from over 40,000 patients between 2000 and 2021 living in demarcated health care districts with high and low levels of […]

(Beyond Pesticides, June 4, 2024) A study published in the most recent edition of the journal Ecotoxicology and Environmental Safety documents for the first time the presence of the herbicide glyphosate in human sperm. The study looked at 128 French men with an average age of 36 years who tested positive for glyphosate in their blood. Seventy-three out of the 128 men were found to also have glyphosate in their seminal plasma. Not only that, the amount of glyphosate in seminal plasma was nearly four times higher than what was detected in the blood.   Methods  The study involved a population of 128 infertile French men from whom seminal and blood plasma samples were collected. The study was conducted at the “Pole Santé Léonard de Vinci” medical center, located centrally near Tours, France. This region is recognized for its urban characteristics as well as being a major agricultural hub, particularly for grain and wine production. The study authors note, “This area reflects the common herbicide exposure in France” and the district ranks third highest in terms of pesticide purchases. While additional qualitative data was collected, only 47 of 128 participants fully completed a questionnaire about their profession, diet (organic or […]

(Beyond Pesticides, May 22, 2024) A study in the journal of Environmental Science and Technology Letters, funded by the National Oceanic and Atmospheric Administration, is the first to find halogenated organic compounds (HOCs) in deep ocean sediment and biota off the coast of California. The test area, known as the Southern California Bight (SCB), is home to historic offshore DDT waste dumping, with part of the SCB designated as a U.S. Environmental Protection Agency (EPA) Superfund site. 49 HOCs were detected in the sediment and biota, many of which are DDT-related and not previously screened for. The presence of these “unmonitored compounds can significantly contribute to the contaminant body burden across a range of marine taxa,” the study states, which leads to impacts on critical food webs and biodiversity. While this study is the first to specifically analyze previously overlooked DDT+ compounds, the results are nothing new. There is a body of science around the bioaccumulation and biomagnification of harmful pollutants that continue to lead to a decline in biodiversity, negative impacts on water and soil, and detrimental human health effects.       To assess the bioavailability of DDT+ and HOCs in the deep ocean food web, this study focused on […]

(Beyond Pesticides, May 17, 2024) Massachusetts Governor Maura Healey (D) proclaimed May 12 -18, 2024 as Multiple Chemical Sensitivity Awareness Week, first established in 1998 in numerous states across the U.S. Multiple Chemical Sensitivity (MCS)—also called chemical intolerance or Toxicant-Induced Loss of Tolerance (TILT), is characterized by disorders in one or more body systems, including respiratory, gastrointestinal, musculoskeletal, and neurological processes. It is thought to be caused by adverse reactions to environmental chemicals and/or biological substances such as mold. Affected individuals suffer fatigue, rashes, muscle and joint pains, memory loss, and other symptoms. The Massachusetts proclamation encourages “residents of the commonwealth to take cognizance” of the event and recognize the distress of their fellow citizens who suffer from MCS. May 12 is also known as International May 12th Awareness Day, an observance started in 2006 in the United Kingdom to educate the public about many diseases associated with sensitivity to chemicals, including MCS, fibromyalgia, and Gulf War Syndrome. While some scientists have considered MCS a psychological or psychosomatic problem, there is increasing support for the reality of MCS as a physical disease distinct from mental or emotional disorders. Yet there are no medical tests that can reliably confirm a diagnosis, […]

(Beyond Pesticides, May 15, 2024) A study published recently in the journal Environmental Research finds a significant correlation between exposure to certain pesticides and an elevated risk of inflammatory bowel disease (IBD), a chronic autoimmune condition of the gastrointestinal tract. The study, adding to the body of science on this subject, evaluates self-reported data from licensed pesticide applicators and their spouses exposed to pesticides for over 20 years. In addition, while some of the chemicals found to be most closely associated with incidents of IBD have been banned from use, they are “forever” chemicals that persist in the environment for generations. These findings demonstrate once again the failings of the current regulatory process to identify hazards before they are put into the environment. The study found evidence that exposure to several organochlorine insecticides (dieldrin, DDT, and toxaphene), as well as organophosphate insecticides (parathion, terbufos, and phorate) and herbicides (2,4,5-T, 2,4,5-TP, and metolachlor), is associated with elevated IBD risk. IBD is a generic term for diseases that result in chronic inflammation of the gastrointestinal tract, such as Crohn’s disease and ulcerative colitis. It is estimated that 6.8 million patients globally suffered from IBD in 2017. IBD may result from an imbalance […]

(Beyond Pesticides, May 13, 2024) A study published in Environmental Research finds that “early life organophosphate pesticide exposure has been linked with poorer neurodevelopment from infancy to adolescence.” Researchers in this study acknowledge that there is still much more to be done in furthering understanding of “neural mechanisms underlying these associations,” and yet there is “notable consistency” in their Center for the Health Assessment of Mothers and Children of Salinas (CHAMACOS) birth cohort study. This study’s findings are consistent with decades of substantial, peer-reviewed scientific literature documenting the adverse health impacts of organophosphate pesticides on public and ecological health. Organic advocates believe that a transition away from chemical-intensive agriculture and land management is the most viable solution to avoid adverse health impacts and end reliance on toxic chemicals in households and communities. The researchers for this study are based at the University of California, Berkley (Center for Environmental Research and Community Health as well as Center for Interdisciplinary Brain Sciences Research), Department of Public Health at University of California, Merced, and Stanford University (Departments of Radiology and Pediatrics in the School of Medicine). “We have reported associations of prenatal [organophosphate] exposure with poorer cognitive function and executive function, and more attention and […]

(Beyond Pesticides, May 3, 2024) Parkinson’s disease (PD) is the second most common neurodegenerative disease in the world after Alzheimer’s. Genetic factors account for only a fraction of PD cases, and for decades scientists have been aware of associations between pesticide exposures and PD. Yet, not everyone exposed to pesticides gets PD. Consequently, neither the genetic nor the environmental hypothesis is fully satisfactory; both may be involved. Thus, there has been great interest in identifying gene variants that affect the risks of PD associated with pesticide exposure. Now a team of University of California at Los Angeles researchers led by neurologist Brent Fogel, MD, PhD has traced a connection between certain gene variants and the occurrence and severity of PD in a cohort of central California PD patients who have had long-term exposure to pesticides. The genes are related to autophagy, the process by which cells organize, degrade, recycle or eject molecules to maintain healthy chemical balance. Autophagy is an essential process throughout the body, including regulation of mitochondria, which are also vital for healthy cellular function. The study supports other research suggesting that autophagy is disturbed in neurodegenerative diseases. As Beyond Pesticides discussed in its April 19 Daily News, PD […]

(Beyond Pesticides, April 30, 2024) Researchers found epigenetic changes, including changes relating to “DNA methylation, histone modification, and differential microRNA expression [which ‘can alter the expression of many disease-related genes’],” in a systematic review and meta-analysis of existing literature published in Environmental Epigenetics. “Our review did provide evidence that pesticide exposure could lead to epigenetic modifications, possibly altering global and gene-specific methylation levels, epigenome-wide methylation, and micro-RNA differential expression,” researchers share in the conclusion of the study. This study is an amalgamation of various studies on epigenetic changes based on a literature review process: “Article review involved [3,529 articles found through] extensive searches across major human health databases, including PubMed, Embase, and Cochrane, and BVS (Biblioteca Virtual em Saúde – the Latin American Health Database). Searches covered articles published through December 2020. Considering the diverse terminologies used to describe the same epigenetic mechanism in this field, the search strategy aimed to encompass all relevant articles by combining a variety of search terms in titles and abstracts. This approach was implemented across PubMed, Embase and Cochrane databases to ensure comprehensive coverage.” Studies were not included if the participants were not considered “healthy individuals” or if the participants had “known inherent/congenital or […]

(Beyond Pesticides, April 26, 2024) Researchers build on existing research when assessing the relationship between long-term exposure to organophosphorus pesticides—widely used in food production and homes and gardens—and the human gut microbiome. In a new study published in Environmental Health, an interdisciplinary research team from University of California, Los Angeles determined, “that exposure to [organophosphorus pesticides] is associated with changes in the abundance of several bacterial groups and differential functional capacity in metabolic pathways supported by the human gut microbiome.” The study draws upon data from a “Parkinson’s, Environment and Gene study (PEG)” in which 190 participants were asked to submit fecal samples and answer interview questions. “[The study] was initially designed to investigate the etiology of Parkinson’s disease (PD) and participants were recruited in two study waves [‘over the full 10-year exposure window’]: 2001–2007 and 2012–2017. At baseline, [Parkinson’s disease] patients were diagnosed within the past 5 years and randomly selected community controls were also recruited,” the research team shares in their Methodology section. “Since 2017, we invited previous study participants who could be contacted to enroll in a pilot study of the gut microbiome. In addition, we invited a household or community member of [Parkinson’s] patients to participate.” […]