(Beyond Pesticides, October 14, 2008) Exposure to glyphosate or MCPA can more than double one’s risk of developing non-Hodgkin lymphoma (NHL), according to a new epidemiological study published in the October issue of the International Journal of Cancer. The case-control study finds a 2.02 odds ratio (OR) for exposure (two times the chance of contracting the illness) to glyphosate, a 2.81 OR for exposure to MCPA, and a 1.72 OR for exposure to herbicides. According to EPA, glyphosate is the most commonly used pesticide in the U.S. with 103 to 113 million pounds used annually. MCPA is a phenoxyacetic acid pesticide, a family of pesticides that has previously been linked to cancer and includes 2,4-D and mecoprop (MCPP). NHL is a cancer of the immune system. There are several different types of NHL, which are differentiated by the type of immune cell that is cancerous, the characteristics of the cancerous cell, and different genetic mutations of the cancerous cells. Treatment for NHL varies depending on NHL type, patient age, and other existing medical conditions. The incidence of NHL has been increasing over the past several decades. The link between pesticides and cancer has long been a concern. While agriculture has […]

(Beyond Pesticides, October 10, 2008) A study published in the American Journal of Epidemiology [Vol. 167, No. 8] finds women who have used herbicides are twice as likely to have meningioma, a specific kind of brain tumor. The study, “Occupational exposure to pesticides and risk of adult brain tumors,” was conducted by the National Cancer Institute. The authors examined the risk of two types of brain cancer, glioma and meningioma, associated with occupational exposure to insecticides and herbicides in a hospital-based, case-control study of brain cancer. Cases were 462 glioma and 195 meningioma patients diagnosed between 1994 and 1998 in three U.S. hospitals. Controls were 765 patients admitted to the same hospitals for nonmalignant conditions. Occupational histories were collected during personal interviews. Exposure to pesticides was estimated by use of a questionnaire, combined with pesticide measurement data abstracted from published sources. The researchers found no overall link between brain cancer and on-the-job exposure to pesticides or herbicides. However, looking closer at the data, the researchers noticed that women who reported using herbicides had a more than doubled risk for meningioma compared with women who never used herbicides, and there were significant trends of increasing risk with increasing years of herbicide […]

(Beyond Pesticides, September 26, 2008) On September 24, the U.S. Ninth Circuit Court of Appeals dismissed Ivory Coast farmworkers’ claims that they were victims of genocide when pesticide exposure made them sterile. The nearly 700 plaintiffs were exposed to the soil fumigant and nematocide 1,2-Dibromo-3-Chloropropane, or DBCP, while working on Dole Food Company farms in Africa. The original First Amended Complaint was filed on April 6, 2007, and despite the latest setback, the Africans’ attorney, Raphael Metzger, said he would pursue a rehearing. Until 1977, DBCP was widely used in U.S. agriculture, when it was banned for all uses except pineapples. In contrast, DBCP was widely used for fruit production in developing countries in to the 1990s in spite of its U.S. regulatory status. “The manufacturers continued making money on [DBCP] by shipping it to Third World countries where farmworkers were given it to use,” Mr. Metzger said. The suit, Abagninin v. Amvac Chemical Co, was filed under the Alien Torts Statute and contended “that such conduct supports claims under the ATS for genocide and crimes against humanity because the conduct was undertaken with knowledge of DBCP’s effects and pursuant to a State or organizational policy.” The court rejected Abagninin’s […]

(Beyond Pesticides, September 23, 2008) According to the Minnesota Department of Agriculture’s 2007 Water Quality Monitoring Report, released in August 2008, the endocrine disrupting herbicide atrazine is detected in pristine lakes in northern Minnesota far from the agricultural fields where it is applied. Metolachlor, acetochlor and dimethenamid are also frequent contaminants, according to the statewide sampling. The report, which uses data collected by a collaborative program between the U.S. Environmental Protection Agency, the Minnesota Department of Agriculture and the Minnesota Pollution Control Agency, analyzed samples from 55 of the state’s lakes. Atrazine was detected in approximately 87% of the 2007 samples, an increase from 2006. The presence of atrazine in such a large percentage of the lakes, many of which are located in non-agricultural areas of northern Minnesota, suggests widespread atmospheric deposition of this chemical (movement through wind and rain). “To some people, it is a bit of a surprise, but the concentrations are low, very low,” Steven Heiskary, a research scientist with the Minnesota Pollution Control Agency (MPCA) told the Star Tribune. Unfortunately, this is not very reassuring, given the fact that many of the developmental impacts linked to atrazine are seen at very low levels, sometimes at just […]

(Beyond Pesticides, September 22, 2008) A study published in the September issue of Environmental Health Perspectives finds that low-dose, short-term exposure to esfenvalerate, a synthetic pyrethroid pesticide, delays the onset of puberty in rats at doses two times lower than U.S. EPA’s stated no observable effect level (NOEL) of 2.0 mg/kg/day. Synthetic pyrethroids are used for everything from lawn care and household insecticides, to mosquito control and agriculture. There are currently 348 pesticide products registered by the U.S. EPA. The researchers conclude: “Although the exact mechanism of action is unknown at this time, we observed the effects at dosage levels below the NOEL established through chronic dietary exposure studies in rats. The U.S. EPA (1998) http://www.epa.gov/fedrgstr/EPA-PEST/1998/April/Day-29/p11372.htm stated that ”˜There is no evidence of additional sensitivity to young rats or rabbits following pre- or postnatal exposure to esfenvalerate.’ The present study shows that immature female rats exposed to 1.0 mg/kg/day are sensitive to this pesticide, as evidenced by their delay in the onset of puberty. Delayed pubertal onset in humans has been associated with low bone mass density (Ho and Kung 2005), and estrogen is necessary for bone mineral acquisition in both girls and boys (Yilmaz et al. 2005). Importantly, a […]

(Beyond Pesticides, September 19, 2008) Adding to the body of epidemiologic evidence linking pesticides to Parkinson’s Disease (PD), a recent study shows a correlation between 100 PD patients and the use of the pesticide rotenone. The study was conducted by physicians and researchers at The University of Texas Health Science Center at Tyler (UTHSCT) and an East Texas Medical Center physician.The study’s lead author is Aman Dhillon, MD, MS, assistant professor of occupational and environmental medicine at UTHSCT. Rotenone is highly toxic to fish and insects, but mildly toxic to warm-blooded animals and humans. It is made from the roots of tropical plants and is used in home gardens and in fisheries management to remove unwanted fish species, said Jeffrey Levin, MD, MSPH, chair of UTHSCT’s Department of Occupational Health Sciences. Dr. Levin is a co-author of the study, published recently in the peer-reviewed Journal of Agromedicine. A total of 184 people participated in the study: 100 had Parkinson’s disease and 84 did not, though they had other neurological disorders. All were patients of George M. Plotkin, MD, Ph.D., a neurologist with a special interest in Parkinson’s disease. Dr. Plotkin, medical director of the ETMC Movement Disorder Center, treats about […]

(Beyond Pesticides, September 17, 2008) A new study has found a link between total chemical contamination in the bodies of pregnant women and the risk of cryptorchidism in their male babies. Mothers whose babies were born with the defect had the highest concentrations of persistent organic pollutants (POPs), mostly organochlorines like PCB and DDE, in their breast milk. The study, entiltled “Cryptorchidism at birth in Nice area (France) is associated with higher prenatal exposure to PCBs and DDE, as assessed by colostrum concentrations,” and published in the journal Human Reproduction, compared prebirth exposure to chemicals, as measured through their mother’s milk, and the risk of undescended testicles or cryptorchidism, during a three-year period. 164 mother/infant pairs were used and within 3-5 days of delivery, the researchers collected samples of colostrums, or “first milk” from the mother. Colostrum is a form of breast milk that is produced late in pregnancy and immediately after birth before the more creamy milk comes in. It is used as a proxy for what was circulating in the mother’s body and in her fetus during pregnancy. The colostrum was analyzed for three different chemical pollutants including seven polychlorinated biphenyls (PCBs), dichloro-diphenyl-trichloro-ethylene (DDE) and dibutyl phthalate (DBP). […]

(Beyond Pesticides, September 16, 2008) Responding to grassroots pressure highlighting the impact of pests and pesticides on public health, the Boston Public Housing Authority (BHA) is promoting integrated pest management (IPM) through its Healthy Pest Free Housing Initiative Project (HPFHI) in the city’s public housing facilities. The program, which was launched after the Committee for Boston Public Housing, a tenant rights group, began looking into the connection between respiratory health, asthma and housing conditions in 1995, is now proving successful. “The project’s goal is to provide intensive in-home and community-based education designed to change individual and community practices regarding pest control and the use of pesticides,” explains John Kane, IPM coordinator and planner for the Boston Housing Authority (BHA). Mr. Kane says that there has been up to a 75 percent reduction in work orders dealing with pests and a huge increase in the quality of life for the residents. Over 1,000 BHA households in eight developments have received in-home and community-based support and education to encourage integrated pest management practices that focus on prevention and use “least toxic” pesticides only as a last resort. BHA hopes to make the project sustainable and expand their efforts into additional developments. “People […]

(Beyond Pesticides, September 11, 2008) The North Carolina Pesticide Board has begun hearing evidence in a case from 2004 over suspected pesticide violations that were investigated after three female Ag-Mart farmworkers gave birth to babies with severe birth defects. In 2006, the family of Carlos Herrera Candelario, who was born without arms or legs, sued Ag-Mart over illegal pesticide exposure resulting in the boy’s birth defects. The case was settled out of court, with Ag-Mart agreeing to pay the medical expenses of the boy for life and provide him with a permanent income, but insisting that the settlement was not an admission of guilt. The current hearing will look at whether Ag-Mart’s farm manager, Jeff Oxley, is indeed guilty of over 200 violations, including forcing workers into the field too soon after dangerous pesticides were applied. The hearing is significant because the company insists that adequate practices are and have been in place to ensure workers are not exposed to pesticides, even though the testimony of Ag-Mart employees runs counter to this claim. This hearing could do a great deal to elucidate the truth about farmworker pesticide exposure, an important issue for the thousands of workers who plant and harvest […]

(Beyond Pesticides, September 8, 2008) Inorganic arsenic may increase the risk of developing type 2 diabetes, according to a study published in the Journal of the American Medical Association by researchers at the Johns Hopkins Bloomberg School of Public Health. Common sources of inorganic arsenic exposure include dietary exposure, drinking water pollution, and contamination associated with arsenic wood preservatives such as sawdust, smoke, direct contact, and hazardous waste sites. The study found that individuals with diabetes have higher levels of arsenic in the urine compared to individuals without diabetes. Researchers examined randomly selected urine samples taken from 788 U.S. adults 20 years or older that participated in a 2003-2004 National Health and Nutrition Examination Survey. The results were adjusted for diabetes risk factors, including body mass index and for organic arsenic compounds found in seafood. “Our findings suggest that low levels of exposure to inorganic arsenic may play a role in diabetes,” said Ana Navas-Acien, MD, PhD, lead author of the study and assistant professor with the Bloomberg School’s Department of Environmental Health Sciences. “While prospective studies are needed to establish whether this association is causal, these findings add to the existing concerns about the long-term health consequences of low […]

(Beyond Pesticides, August 26, 2008) On August 20, 2008, the 9th U.S. Circuit Court of Appeals reversed a 2006 ruling by the U.S. District Court for the Eastern District of California (Sacramento) that required the state of California to establish limits on air pollution associated with pesticide use. The Appeals Court found that the lower court did not have jurisdiction to impose solutions under the Clean Air Act. According to the plaintiffs represented by the Center for Race, Poverty and the Environment (CPRE), an environmental justice litigation organization based in San Francisco, pesticides are the fourth largest source of smog-forming volatile organic compound (VOC) emissions in California’s San Joaquin Valley. Prior to 2005, the state did not regulate this source of pollution from the politically powerful agriculture industry, even though the state had made a promise to reduce VOC emissions from pesticides by 20% more than a decade earlier in its Ozone State Implementation Plan, a smog clean up plan adopted pursuant to the Clean Air Act. El Comité para el Bienestar de Earlimart and the Association of Irritated Residents, represented by CRPE, filed suit (El Comité para el Bienestar de Earlimart, et al. v. Warmerdam, et al.) in U.S. […]

(Beyond Pesticides, August 25, 2008) A recent study by Spanish researchers has found a connection between an ncreased risk of childhood obesity and exposure to the organochlorine pesticide and contaminant hexachlorobenzene (HCB) before birth. Entitled “Exposure to hexachlorobenzene during pregnancy increases the risk of overweight in children aged 6 years,” the article was published online by Acta Paediatrica at the end of July. Found as a contaminant in the wood preservative pentachlorophenol, widely used in the U.S., HCB is extremely persistent in the environment. The Environmental Protection Agency (EPA) says it “has been listed as a pollutant of concern to EPA’s Great Waters Program due to its persistence in the environment, potential to bioaccumulate, and toxicity to humans and the environment.” Researchers studied 405 infants in Menorca, Spain. They measured persistent organic pollutants (HCB, PCBs, p,p’-DDE, and p,p’-DDT) in their cord blood and then measured each child’s height and weight at 6.5 years of age. “Overweight” was defined as the 85 percentile or higher on the US National Center for Health Statistics/WHO reference body mass index (BMI). They also took into account information about the mothers, such as age, education, socio-economic status, smoking, alcohol use, weight, and diet. All 405 […]

(Beyond Pesticides, August 15, 2008) With a public comment period that ends Monday, August 18, 2008, the U.S. Department of Justice, Disability Rights Section, Civil Rights Division proposes rulemaking that fails to recognize chemical sensitivity (CS) and environmental illnesses as disabilities that may require specific access standards. In a public comment to be submitted next week, Beyond Pesticides urges the Justice Department to specifically include access requirements for those with CS and environmental illnesses in its rulemaking. The organization is urging the public to send comments as well, and invites sign-ons to the Beyond Pesticides’ comment. The comment says, “The proposed rule errs in omitting environmental illness and chemical sensitivity with a justification that people with the illness may have a “sensitivity [that does] not rise to the level needed to constitute a disability.” This statement is false and out of step with environmental medicine which diagnoses CS as a chemical-induced illness from which patients suffer with debilitating effects. Similar to other disabilities, a diagnosis reflects a finding that patients cannot function as a result of exposure to neurotoxic chemicals. Eliminating the chemical exposure substantially increases their ability to function and lead normal lives.” The comment continues, “As an organization […]

(Beyond Pesticides, August 8, 2008) University of California Davis Cancer Center physicians recently released results of research showing that Vietnam War veterans exposed to Agent Orange have greatly increased risks of prostate cancer and even greater risks of getting the most aggressive form of the disease as compared to those who were not exposed. The findings, which appear online now and will be published in the September 15 issue of the journal Cancer, are the first to reliably link the herbicide with this form of cancer by studying a large population of men in their 60s and the prostate-specific antigen (PSA) test to screen for the disease. “While others have linked Agent Orange to cancers such as soft-tissue sarcomas, Hodgkin’s disease and non-Hodgkin’s lymphoma, there is limited evidence so far associating it with prostate cancer,” said Karim Chamie, lead author of the study and resident physician with the UC Davis Department of Urology and the VA Northern California Health Care System. “Here we report on the largest study to date of Vietnam War veterans exposed to Agent Orange and the incidence of prostate cancer.” Chamie also said that, unlike previous studies that were either too small or conducted on men […]

(Beyond Pesticides, August 4, 2008) According to a new Center for Public Integrity investigation, Perils of the New Pesticides, pyrethrins and pyrethroids were responsible for more than 26 percent of all major and moderate human incidents involving pesticides in the United States in 2007, up from just 15 percent in 1998 ”” a 67 percent increase. This is based on an analysis of adverse reaction reports filed with the Environmental Protection Agency by pesticide manufacturers. As a result of the Center’s investigation, the director of the EPA’s Office of Pesticide Programs said the agency would begin a broad study of the human health effects of these chemicals this year. “The alarming rise of pesticide-related incidents attributed to pyrethrin and pyrethroid affiliated products is a serious concern for the millions of households that use them,” said Center Executive Director Bill Buzenberg. “The Center for Public Integrity uncovered this public safety issue through more than a dozen Freedom of Information Act requests and crunching the data. This should be basic public information if the EPA were doing its job.” Data from the American Association of Poison Control Centers reveals a similar trend that supports the EPA data analyzed by the Center. The […]

(Beyond Pesticides, July 25, 2008) San Francisco, California —  On July 24, 2008,  a broad coalition of farmworker, public health, and environmental groups filed a lawsuit against the Environmental Protection Agency (EPA) to stop the continued use of a hazardous pesticide called endosulfan. The coalition is demanding action from EPA to protect children, farmworkers, and endangered species. Endosulfan is an organochlorine, part of the same family of chemicals as DDT, which EPA banned in 1972. Like other organochlorine pesticides, endosulfan is persistent in the environment and poisons humans and wildlife both in agricultural areas and in regions far from where it was applied. “This dangerous and antiquated pesticide should have been off the market years ago,” said Karl Tupper, a staff scientist with Pesticide Action Network. “The fact that EPA is still allowing the use of a chemical this harmful shows just how broken our regulatory system is.” Acute poisoning from endosulfan can cause headaches, nausea, vomiting, convulsions, and in extreme cases, unconsciousness and even death. Studies have linked endosulfan to smaller testicles, lower sperm production, and an increase in the risk of miscarriages. One glaring omission in the EPA’s decision is its failure to consider risks to children. A […]

(Beyond Pesticides, July 24, 2008) Although the text of the Department of Labor’s proposal on workplace safety standards has not been made public, the Washington Post reports that the proposal will likely weaken an already inadequate risk assessment process, thus putting workers at an even greater risk of health effects from toxic chemical exposure. This proposal follows on the heels of news that the Environmental Protection Agency (EPA) has recently lowered its value of a human life, which will make it easier to avoid environmental regulations. Peg Seminario, director of health and safety policy at the AFL-CIO, accused the Department of Labor of secrecy and said, “They are trying to essentially change the job safety and health laws and reduce required workplace protections through a midnight regulation.” According to the Post, changing the risk assessment process for workplace safety has become the priority for the Department of Labor. Undoubtedly, this prioritization came under pressure from industries, which claim that the risk assessment process overestimates worker risk. However, risk assessments, like those that the EPA employs in regulating pesticides, already allow for a 10-fold increase in risk of health effects for workers than they do for the general public. Risk assessments […]

(Beyond Pesticides, July 17, 2008) In a new study published in Environmental Health Perspectives, researchers have found an increased occurrence of intersex toads in areas with greater agricultural land cover. This points to a link between certain pesticides and endocrine disruption, a change in the hormonal balance that can have sexual and reproductive effects. Such results implicate pesticides in the decline of amphibian populations, and suggests that these chemicals are also adversely affecting humans. The study, which was conducted in south Florida, looked at cane toads, Bufo marinus, at five sites with differing land use patterns ranging from suburban to nearly completely agricultural (primarily sugarcane and vegetables). Researchers examined physical characteristics such as coloration, sexual organs, and forelimb length, as well as hormone concentrations, and found a higher rate of feminization for toads in agricultural areas. In these areas, glyphosate (the active ingredient in Round Up herbicide) and atrazine (an herbicide) use is common. Tyrone Hayes, PhD, was one of the first to document the endocrine disrupting effects of atrazine on frogs in a laboratory setting. Countering any doubts of why this work is important, Dr. Hayes said, “People often say, ”˜It is just frogs, so who cares?’ Well it […]

(Beyond Pesticides, July 16, 2008) People exposed to pesticides are more likely to suffer changes in nerve responses and severe weakness in their neck and limb muscles in the days before they succumb to their symptoms. This is according to a new study, which found that the major cause of death was as a result of respiratory failure following acute organophosphate poisoning. The study entitled, “The Spectrum of Intermediate Syndrome Following Acute Organophosphate Poisoning: A Prospective Cohort Study from Sri Lanka” published in the open-access journal Public Llibrary of Science (PloS) Medicine was a collaboration between researchers from Sri Lanka, Australia, and the UK. These researchers examined and assessed 78 consenting symptomatic patients with organophosphate poisoning and found that 10 suffered severe weakness in their neck and limb muscles and five of these eventually developed respiratory failure. Respiratory failure is the major cause of death after poisoning by organophosphates. Lead author Pradeepa Jayawardane, clinical pharmacology lecturer at the University of Sri Jayawardenepura in Sri Lanka, and colleagues realized that there are changes in nerve transmission that are presented before individuals with organophosphate poisoning develop muscle weakness, also known as intermediate syndrome (IMS). IMS results in muscle weakness in the limbs, […]

(Beyond Pesticides, July 15, 2008) After three years of deliberation, the U.S. Environmental Protection Agency (EPA) proposed new rules for five highly toxic fumigant pesticides on July 10, 2008. Environmental health, community and farmworker groups say the rules, while substantially better than the past, still fall short of protecting people, workers and the environment. The rules will be published in the Federal Register on July 17, 2008.The fumigant review, mandated by the 1996 Food Quality Protection Act, was conducted as a combined evaluation of five commonly used fumigants, called the “Fumigant Cluster Assessment.” The five fumigants included in the assessment are methyl bromide, metam sodium, metam potassium, dazomet, and chloropicrin. Methyl bromide was slated for phaseout by January 2005 under the Montreal Protocol because it is a potent ozone depletor, but the Bush Administration has sought annual “critical use exemptions,” keeping it on the market. Fumigants, which are among the most toxic chemicals used in agriculture, are gases or liquids that are injected or dripped into the soil to sterilize a field before planting. Even with plastic tarps on the soil, fumigants escape from the soil and drift through the air into schools, homes, parks and playgrounds. Strawberries, tomatoes, peppers, […]

*July 14, 2008 Update: Officials have reported that the cause for poisoning of these Maryland residents was jimsonweed, not pesticides. Jimsonweed was found in the garden of the home where the stew had been prepared. Symptoms are similar to organophosphate pesticide poisonings. (Source: NBC4) (Beyond Pesticides, July 10, 2008) Showing just how toxic common pesticides can be, six people in Gaithersburg, Maryland who ate potentially contaminated stew have been hospitalized with probable pesticide poisoning. Reports say that mint leaves from a backyard garden that were in a potato stew are suspected to have contained organophosphate pesticide residues. Unfortunately, the media is reporting this as a case of failing to wash produce properly, which does not address the root of the pesticide poisoning problem””that pesticides are hazardous and their uses cause harm. In fact, when EPA registers pesticides for use in food production, whether in the garden or commercial agriculture, it does not disclose or warn the public about pesticide residues or require the washing of treated food commodities, and it does not point to the availability of nontoxic alternatives. The Washington Post reports, “In a textbook illustration of the importance of thoroughly washing plants and vegetables before eating them, authorities […]

(Beyond Pesticides, July 1, 2008) On behalf of the African American residents of Mossville, Louisiana, the non-profit, public interest law firm Advocates for Environmental Human Rights (AEHR) on June 23, 2008 filed with the Inter-American Commission on Human Rights (IACHR) a detailed account of the human rights abuses suffered by residents as a consequence of governmental approvals that allow industrial facilities to dump millions of pounds of toxic chemicals every year. The filing is an amended petition (Petition No. P-242-05), which includes a response to the U.S. Government’s arguments that attempt to defend its flawed environmental regulatory system that perpetuates environmental racism and denies basic human rights in Mossville and other similarly situated communities of color, according to AEHR. The petition states: “[The residents of] Mossville suffer from severe health problems, elevated levels of cancer-causing and hormone-disrupting chemicals, a devastated environment, and a deteriorated quality of life, all of which arise from governmental approvals of highly toxic industrial development in and around Mossville. The United States government and its political subdivisions have authorized fourteen industrial facilities to manufacture, process, store, and discharge toxic and hazardous substances in close geographic proximity to Mossville residents. Three of these facilities — an oil […]

(Beyond Pesticides, June 6, 2008) A recent study by the National Institutes of Health (NIH), including the National Institute of Environmental Health Sciences (NIEHS) and the National Cancer Institute (NCI), finds pesticide applicators with regular exposure to pesticides to be at a greater risk of type-2 diabetes. Published in the American Journal of Epidemiology (DOI: 10.1093/aje/kwn028), the study shows specific pesticides produce between a 20 and 200 percent increase in risk. Researchers looked at data from 31,787 pesticide applicators in North Carolina and Iowa over a period of five years. In that period, 1,171, or 3.7 percent, had developed diabetes, particularly for applicators in the highest category of lifetime days of use of any pesticide. “The results suggest that pesticides may be a contributing factor for diabetes along with known risk factors such as diabetes, lack of exercise and having a family history of diabetes,” said Dale Sandler, PhD, chief of the Epidemiology Branch of NIEHS. “Although the amount of diabetes explained by pesticides is small, these new findings may extend beyond the pesticide applicators in the study.” Freya Kamel, PhD, of NIEHS noted that “all of the seven pesticides” associated with an increased risk of type 2 diabetes are […]