(Beyond Pesticides, December 15, 2009) Exposure to the endocrine-disrupting herbicide atrazine triggers the release of stress hormones in rats, according to a new study published in the December 2009 issue of the journal Toxicological Sciences. The researchers believe this may explain how the popular weed killer produces some its harmful reproductive effects. The study, “Characterization of the Hypothalamic-Pituitary-Adrenal Axis Response to Atrazine and Metabolites in the Female Rat,” was conducted by the Environmental Protection Agency’s (EPA) National Health and Environmental Effects Research Laboratory. According to a December 4 analysis by Environmental Health Sciences, a foundation-funded journalism organization, the researchers discovered that female rats fed atrazine at the time of ovulation released a flow of stress hormones that are known to interfere with hormones essential for reproduction. The findings reveal one way atrazine may impact female reproduction. Elevated stress hormones can disrupt the hormone signals that spur ovulation. Such a stress response to atrazine could partially explain why previous studies find that the herbicide inhibits reproduction. The stress reaction is similar to that seen when the animals are restrained against their will. One of the most widely used agricultural pesticides in the U.S., atrazine can currently legally be applied before and […]

(Beyond Pesticides, December 3, 2009) Pregnant women should reconsider applying insect repellent after a study finds a link to an increasingly common birth defect. European researchers have found an association between mothers who used insect repellent in the earliest phase of pregnancy and an increased rate of “hypospadias” in the penises of their male children. Hypospadias is the condition where the opening of the penis is in the wrong place – usually back from the tip and on the underside – and often requires corrective surgery. The condition is thought to affect around one to two baby boys in every 500. According to a report published online November 30 in Occupational and Environmental Medicine and entitled “Use of biocides and insect repellents and risk of hypospadias,” infants born to mothers who used insect repellent during the first trimester of pregnancy are more likely to have hypospadias (OR 1.81, 95% CI 1.06 to 3.11) after adjusting for other factors. The research includes 471 babies with hypospadias and 490 acting as a comparison group. Their mothers were asked a series of questions, including whether they had been exposed to insect repellents and biocide chemicals, such as pesticides or weedkillers. They were asked […]

(Beyond Pesticides, December 1, 2009) A new study published in the November 2009 issue of Occupational and Environmental Medicine, adds rhinitis, the inflammation of the mucous lining of the nose, to the long list of ailments linked to pesticide exposure. “Rhinitis associated with pesticide exposure among commercial pesticide applicators in the Agricultural Health Study,” examined data from 2,245 Iowa commercial pesticide applicators and evaluated the association between rhinitis and 34 pesticides used in the past year. Seventy-four percent of commercial pesticide applicators in the study reported at least one episode of rhinitis in the past year (current rhinitis), compared with about 20-30% of the general population. Pesticide exposure and rhinitis were assessed at enrollment using two self-administered questionnaires. The first, completed at enrollment, obtained detailed information on use of pesticides on the market at the time of enrolment as well as smoking history, current agricultural activity and demographics. The second questionnaire, sent one month later, more detailed information on the pesticides, as well as medical history, including rhinitis, conjunctivitis, sinusitis and asthma. Respondents reported using 16 herbicides, 11 insecticides, five fungicides and two fumigants in the past year. Five of the pesticides were significantly positively associated with current rhinitis: the […]

(Beyond Pesticides, November 17, 2009) According to a new study by researchers at the University of Wisconsin-Madison, exposure to low levels of the organophosphate insecticide chorpyrifos during pregnancy can impair learning, change brain function and alter thyroid levels of offspring into adulthood for tested mice, especially females. The study, “Long-term sex selective hormonal and behavior alterations in mice exposed to low doses of chlorpyrifos in utero,” was led by Beyond Pesticides board member and professor of zoology and environmental toxicology, Warren Porter, PhD. Read the full analysis of the study on the Rodale Institute website. On June 8, 2000, the Environmental Protection Agency (EPA) and Dow AgroSciences, reached an agreement to stop the sale of most home, lawn and garden uses for chlorpyrifos because of its health risks to children. However, its use continues in agriculture. According to advocates, this new study provides further evidence for the need to ban chlorpyrifos and fully protect farmworkers, their families, and rural communities from the toxic hazards of this outdated, unnecessary pesticide. According to the Rodale Institute, which provided part of the funding for the study, “The new animal study accentuates the risk of ultra-low levels of the common pesticide chlorpyrifos to cause […]

(Beyond Pesticides, October 30, 2009) A recent study shows that women who use insecticides are at elevated risk for autoimmune diseases such as rheumatoid arthritis and lupus. The results of the yet unpublished study were presented on October 17, 2009 at the American College of Rheumatology annual meeting in Philadelphia, PA. The study, which looked at more than 75,000 women, shows that those who spray insecticides at least six times per year have almost two and a half times the risk of developing lupus and rheumatoid arthritis versus those who do not use insecticides. The risk doubles if insecticides were used in the home for 20 years or more. Hiring a gardener or commercial company to apply insecticides also resulted in a doubling of risk, but only if they were used long-term, says Christine G. Parks, PhD, an epidemiologist with the National Institute of Environmental Health Sciences in Research Triangle Park, N.C., one of the lead researchers who analyzed data from the Women’s Health Initiative (WHI) Observational Study. “Our new results provide support for the idea that environmental factors may increase susceptibility or trigger the development of autoimmune diseases in some individuals,” said Dr. Parks. While the study does not […]

(Beyond Pesticides, October 27, 2009) U.S. District Judge Paul Huck (Miami) has said a multimillion dollar judgment against U.S. food giant Dole and the Dow Chemical Company cannot be enforced because, “[T]he judgment was rendered under a system which does not provide impartial tribunal or procedures compatible with the requirements of due process of law, and the rendering court did not have jurisdiction over Defendants.” A trial court in Chinandega, Nicaragua, had awarded the money in 2005 to 150 Nicaraguan citizens who believe they were injured by exposure to the pesticide dibromochloropropoane, or DBCP, when they worked on Dole banana plantations between 1970 and 1982. This actiion was taken despite findings in the U.S. that DBCP causes sterility and regulatory action to remove it from the market. The trial court awarded Plaintiffs approximately $97 million under “Special Law 364,” enacted by the Nicaraguan legislature in 2000 specifically to handle DBCP claims. The average award was approximately $647,000 per plaintiff. According to the Nicaraguan trial court, these sums were awarded to compensate plaintiffs for DBCP-induced infertility and its accompanying adverse psychological effects. In similar cases in the past, the companies have refused to pay. Dow Chemical has called such judgments “unenforceable” […]

(Beyond Pesticides, October 26, 2009) A new study conducted in China finds that people with organophosphate pesticides in their homes are more likely to have suicidal thoughts. According to the study, “Pesticide exposure and suicidal ideation in rural communities in Zhejiang province, China,” published in the October issue of the WHO Bulletin, there is biological evidence that chronic low-grade exposure to organophosphate pesticides, which are very easily absorbed into the body through the skin and lungs, may have adverse effects on mental health. The study was carried out in the central/coastal region of China, a relatively wealthy area with a rapidly developing economy. In a very large survey of mental health in rural community residents, participants were also asked about how they stored pesticides. The study found that people who stored pesticides at home, i.e. those with more exposure, were more likely to report recent suicidal thoughts. Supporting this, the survey also found suicidal thoughts to be associated with how easily accessible these pesticides were in the home and that the geographic areas with highest home storage of pesticides also had highest levels of suicidal thoughts in their populations. “Organophosphate pesticides are widely used around the world. They are particularly […]

(Beyond Pesticides, October 21, 2009) The U.S. Environmental Protection Agency (EPA) is making available the battery of scientific assays and test guidelines for conducting the assays for each of 67 chemicals included for Tier 1 testing for endocrine disrupting effects during the next three months. This comes after the Office of Management and Budget (OMB) instructed EPA to use existing toxicity data rather than require companies to conduct new tests to determine whether chemicals can damage the human endocrine system. With the availability of the assays and test guidelines, EPA will move forward with issuing test orders to manufacturers to compel the generation of the needed data. However, acquisition of new, relevant data may be limited. This is because after EPA submitted the request for additional information for OMB approval, the Office issued a directive that approved EPA’s request to collect additional data for the 67 chemicals but warned the agency that it should “to the greatest extent possible” accept existing data to satisfy test requirements. The OMB directive, which observers say contains unusually strong language, is being hailed by industry groups that had been concerned about the prospects for expensive testing mandates. But many environmental groups and scientists say […]

(Beyond Pesticides, September 29, 2009) A new study reveals that children exposed to agricultural pesticides applied near their home have up to twice the risk of developing the most common form of childhood leukemia, according to the Northern California Cancer Center (NCCC). The study, “Residential proximity to agricultural pesticide applications and childhood acute lymphoblastic leukemia,” published in the October issue of Environmental Research, used a unique California database to reveal an elevated risk in acute lymphoblastic leukemia (ALL) among children living near applications of certain categories of pesticides used in agriculture. The study, led by Rudolph Rull, Ph.D., shows an elevated risk of ALL associated with moderate exposure, but not high exposure, to pesticides classified as organophosphates (odds ratio (OR) 1.6), chlorophenoxy herbicides (OR 2.0), and triazines (OR 1.9), and with agricultural pesticides used as insecticides (OR 1.5) or fumigants (OR 1.7). California is one of the few states in the country that requires active reporting of pesticide applications, including time, place, and the type and amount of pesticide used. For this study, researchers were able to link children’s entire residential histories from birth to the time of case diagnosis to this pesticide-use reporting database and identify agricultural pesticides that […]

(Beyond Pesticides, September 18, 2009) Previously documented in the Potomac River, which flows through downtown Washington, DC, the occurrence of “intersex” fish is now found to be nationwide. U.S. Geological Survey (USGS) researchers published their study, “Widespread occurrence of intersex in black basses from U.S. rivers” in the online edition of Aquatic Toxicology. USGS researchers examined 16 different species of fish across the U.S. between 1995 and 2004. The condition of intersex fish, male fish producing eggs, is most commonly found in smallmouth and largemouth bass. One third of male smallmouth bass and one fifth of the male largemouth bass are intersex. Scientists tested sites in the Apalachicola, Colorado, Columbia, Mobile, Mississippi, Pee Dee, Rio Grande, Savannah, and Yukon River basins. Research shows intersex fish in approximately one-third of all examined sites. The only site where researchers found no intersex fish is the Yukon River basin. While the study did not look for the causes for intersex fish, scientists believe endocrine disruptors, chemicals that interfere with the body’s hormonal systems, are certainly to blame. “We know that endocrine-active compounds have been associated with intersex in fish, but we lack information on which fish species are most sensitive to such compounds, […]

(Beyond Pesticides, September 16, 2009) A new study published in the September issue of Archives of Neurology reports that the risk of Parkinsonism doubled with increased occupational exposure to pesticides, including eight agents associated with experimental Parkinsonism. These data add to the growing number of studies that lend credence to a causative role of certain pesticides in neurological disorders. The study, “Occupation and Risk of Parkinsonism: A Multicenter Case-Control Study,” set out to investigate occupations, specific job tasks, or exposures and risk of parkinsonism in collaboration with eight movement disorders centers in North America including, the Parkinson’s Institute, CA, Department of Neurology, Baylor College of Medicine and Department of Neurology, Beth Israel Medical Center, New York. The investigation focused on five occupations previously suggested as posing an increased risk of Parkinsonism: agriculture, education, healthcare, welding, and mining. This examination of toxicant exposures included solvents and pesticides putatively associated with Parkinsonism. 519 people with Parkinson’s disease and 511 similar people who did not have Parkinson’s were studied. Overall, the study finds that those whose jobs involve using pesticides are 80 percent more likely to develop the condition. The data reveals that any exposure to the herbicide 2,4-dichlorophenoxyacetic acid (2,4-D) almost triples […]

(Beyond Pesticides, September 10, 2009) Some researchers are suggesting that sanitizers made with essential oil are a solution to harmful soaps with antibacterials. Cinnamon oil, according to many recent studies, has been shown to have strong antiseptic properties, without creating the problem of antibiotic-resistant bacteria. Many antibacterial products, such as those containing triclosan, work by killing some, but not all bacteria, which means that widespread use has led to resistant strains and cross resistance with antibiotics. A recent study however, found that a cinnamon oil solution was just as effective at killing several common bacteria as many other antiseptics commonly used in hospitals. The team of surgeons conducting the research tested several common essential oils, and found that each has demonstrated promising efficacy against several bacteria, including multi-resistant strains. Another study by researchers in France in 2008 tested bactericidal activity of 13 different essential oils and had similar results, with cinnamon being the most effective. At concentrations as low as 10 percent or less, cinnamon oil was also effective against several antibiotic-resistant strains of bacteria, such as Staphylococcus and E. coli. One pediatrician in New Jersey, Dr. Lawrence D. Rosen, who advocates natural health solutions on his blog, wholechildcenter.org, recommends […]

(Beyond Pesticides, August 17, 2009) The four-day testing period the U.S. Environmental Protection Agency (EPA) commonly uses to determine ”˜safe’ levels of pesticide exposure for humans and animals could fail to account for the long-term effects of toxic chemicals, University of Pittsburgh researchers report in the September edition of Environmental Toxicology and Chemistry. The team found that the highly toxic pesticide endosulfan, a neurotoxin banned in several nations but still used extensively in U.S. agriculture, can exhibit a “lag effect” with the fallout from exposure not surfacing until after direct contact has ended. The findings build on a 10-year effort by Rick Relyea, Ph.D., an associate professor of biological sciences in Pitt’s School of Arts and Sciences, to understand the potential links between the global decline in amphibians, routine pesticide use, and the possible threat to humans in the future. The team exposed nine species of frog and toad tadpoles to endosulfan levels “expected and found in nature” for the EPA’s required four-day period, then moved the tadpoles to clean water for an additional four days, Jones reported. Although endosulfan was ultimately toxic to all species, three species of tadpole showed no significant sensitivity to the chemical until after they […]

(Beyond Pesticides, August 12, 2009) A new study examining the effects of the mosquito repellent DEET on insects, mice and human proteins reports that the chemical interferes with a prominent central nervous system enzyme. This effect is magnified when exposure to DEET is combined with exposure to certain other pesticides. Entitled, “Evidence for inhibition of cholinesterases in insect and mammalian nervous systems by the insect repellent deet,” and published in BioMed Central (BMC) Biology, the study utilized toxicological, biochemical and electrophysiological techniques to show that DEET is not simply a behavior-modifying chemical, but that it also inhibits cholinesterase activity in both insect and mammalian neuronal preparations. The researchers examined DEET’s effects on mosquitoes, cockroach nerves, mouse muscles, and enzymes purified from fruit flies and humans. Applications of DEET slowed or halted the actions of the enzyme acetylcholinesterase. This enzyme is crucial for regulating nerve impulses in both insects and mammals, and once its functions are disrupted, neuromuscular paralysis, leading to death by asphyxiation result. In humans, symptoms include headache, exhaustion and mental confusion together with blurred vision, salivation, chest tightness, and muscle twitching and abdominal cramps. The study also investigated the consequences of DEET interactions with carbamate insecticides on the […]

(Beyond Pesticides, August 7, 2009) A recent study published in the journal Environmental Health Perspectives has added to evidence that certain pesticides significantly increase one’s risk of developing Parkinson’s disease (PD). Researchers found that rural residents who drank private well water within 500 meters of fields sprayed with certain pesticides had an increased – up to 90 percent – risk of developing PD, and those with Parkinson’s “were more likely to have consumed private well water, and had consumed it on average 4.3 years longer.” The study evaluated more than 700 people, including carefully chosen controls, in Fresno, Kent, and Tulare counties. 17 percent reported drinking private well water between 1974 and 1999. Researchers focused on wells’ proximity to agricultural fields sprayed with pesticides, since private wells are not regulated, and many are shallow enough to be contaminated by pesticides seeping into groundwater. Researchers looked at 26 pesticides and six in particular, “selected for their potential to pollute groundwater or because they are of interest for PD, and to which at least 10% of our population were exposed.” Those are: diazinon, chlorpyrifos, propargite, paraquat, dimethoate, and methomyl. Propargite exposure was most closely correlated with incidence of PD, with a 90 […]

(Beyond Pesticides, July 31, 2009) A group of advocates and experts is warning that pesticide pollution from farm fields and households is contributing to the Chesapeake Bay’s decline, and may well be linked to declines in frogs across the region and intersex fish seen in the Potomac River. In a report released yesterday, the group calls on federal, state and local government to accelerate research into what threats pesticide contamination may pose to the bay, and to step up efforts to reduce such toxic pollution. “The thing that alarms us the most are the endocrine disruptors and the findings that have come out about intersex fish and frogs with reproductive problems,” said Robert SanGeorge, director of the Pesticides and the Chesapeake Bay Watershed Project. Endocrine disruptors are chemicals that mimic the natural hormones in humans or animals and can disrupt their growth and reproduction. The project is a partnership between the Maryland Pesticides Network and the Johns Hopkins Center for a Livable Future. The group’s warning and recommendations are the product of a two-year study, in consultation with scientists, public health experts, government officials, watermen, environmentalists, farmers and pest management industries. The report comes as federal and state governments attempt […]

(Beyond Pesticides, July 30, 2009) A new report from the Institute of Medicine (IOM) and sponsored by the U.S. Department of Veterans Affairs finds suggestive but limited evidence that exposure to Agent Orange and other herbicides used during the Vietnam War is associated with an increased chance of developing ischemic heart disease and Parkinson’s disease in Vietnam veterans. The report is the latest in a congressionally mandated series by IOM that every two years reviews the evidence about the health effects of these herbicides and a type of dioxin – TCDD – that contaminated some of the defoliants. A finding of “limited or suggestive evidence of an association” means that the evidence indicates there could be a link between exposure to a chemical and increased risk for a particular health effect, though conflicting results from studies, problems with how the studies were conducted, or other confounding factors limit the certainty of the evidence. Until now, the cumulative evidence had been inadequate to draw conclusions about whether these two conditions may be associated with veterans’ exposures to herbicides or TCDD. Ischemic heart disease – a condition characterized by reduced blood supply to the heart, which can lead to heart attack and […]

(Beyond Pesticides, July 29, 2009) A new study by researchers at the Lombardi Comprehensive Cancer Center at Georgetown University finds a higher level of common household pesticides in the urine of children with acute lymphoblastic leukemia (ALL), a cancer that develops most commonly between three and seven years of age. The findings are published in the August issue of the journal Therapeutic Drug Monitoring. Researchers, in the study entitled, “Pediatric Acute Lymphoblastic Leukemia and Exposure to Pesticides,” caution that these findings, which do not establish a cause-and-effect relationship, suggest an association between pesticide exposure and development of childhood ALL. “In our study, we compared urine samples from children with ALL and their mothers with healthy children and their moms. We found elevated levels of common household pesticides more often in the mother-child pairs affected by cancer,” says the study’s lead investigator, Offie Soldin, Ph.D., an epidemiologist at Lombardi. Dr. Soldin cautions, “We shouldn’t assume that pesticides caused these cancers, but our findings certainly support the need for more robust research in this area.” Previous studies have found that exposures to certain pesticides increases the risk of developing certain cancers and degenerative diseases. The study was conducted between January 2005 and […]

(Beyond Pesticides, July 28, 2009) A new study by researchers at the National Food Institute, Technical University of Denmark shows that exposure to a mixture of pesticides and other chemicals has a synergistic effect on the development of male sex organs. Synergy occurs when the effect of multiple chemicals is greater than the sum of the individual effects. The study, “Synergistic Disruption of External Male Sex Organ Development by a Mixture of Four Antiandrogens,” was published July 15, 2009 in the online edition of Environmental Health Perspectives. The researchers designed their study to determine the consequences of simultaneous exposure to multiple “antiandrogens.” An antiandrogen, or androgen antagonist, is any of a group of hormone receptor antagonist compounds that are capable of preventing or inhibiting the biologic effects of androgens, male sex hormones, on normally responsive tissues in the body. Disrupting the action of androgens during gestation, certain chemicals present in food, consumer products and the environment can induce irreversible malformations of sex organs among male offspring. The team investigated the effects of mixtures of a widely used plasticizer, di(2-ethylhexyl) phthalate (DEHP), used in medical devices such as IV bags and tubing, beauty products, PVC toys, vinyl shower curtains, car seats, […]

(Beyond Pesticides, July 14, 2009) With language to exclude farmworkers from coverage, on July 10, 2009, Senator Kay Hagan (D-NC) introduced Senate Amendment 200 to the Affordable Health Choices Act, the health care reform bill being considered in the Senate Committee on Health, Education, Labor and Pensions (HELP). According to the advocacy group Farmworker Justice, her amendment would exclude from the definition of “employees” any “temporary or seasonal agricultural workers ”¦ for the purposes of determining the size of an employer.” Agricultural employers of seasonal farmworkers would not be required to participate in the system because they would be considered to be too small. Seasonal farmworkers would be denied health care coverage. “There can be no good explanation for why Senator Hagan thinks it would be a good idea to exclude seasonal farmworkers from access to affordable health care coverage, other than that she is pandering to agricultural employers and upholding the long tradition of excluding some of America’s lowest paid and hardest working employees from the benefits that other workers receive,” said attorney Kate Woomer-Deters of the North Carolina Justice Center. Farmworkers in the U.S. earn an average of $12,500 to $15,000 per year. They work in some of […]

(Beyond Pesticides, July 1, 2009) Researchers have found that one of the so-called “inert” ingredients in the popular herbicide product Roundup can kill human cells, particularly embryonic, placental and umbilical cord cells. Over 4,000 inert ingredients are approved for use in the U.S. and can be mixed with pesticide “active” ingredients; however these chemicals are not disclosed to consumers or users on pesticide product labels due to EPA’s intepretation (many would say incorrect interpretation) of federal pesticide law. Many inerts are classified as highly toxic, while others have not been adequately studied. About 100 million pounds of Roundup are applied to U.S. farms and lawns every year and until now, most health studies have focused on the safety of glyphosate the active ingredient in Roundup, rather than the mixture of “inert” ingredients found in the herbicidal product. In this new study, “Glyphosate Formulations Induce Apoptosis and Necrosis in Human Umbilical, Embryonic, and Placental Cells,” researchers found that Roundup’s inert ingredients amplified the toxic effect on human cells””even at concentrations much more diluted than those used on farms and lawns, and which correspond to low levels of residues in food or feed. One specific inert ingredient, polyethoxylated tallowamine, or POEA, was […]

(Beyond Pesticides, June 30, 2009) How much do we know about the food we buy at our local supermarkets and serve to our families? In Food, Inc., producer-director Robert Kenner and investigative authors Eric Schlosser (Fast Food Nation) and Michael Pollan (The Omnivore’s Dilemma) lift the veil on the U.S. food industry — an industry that has often put profit ahead of consumer health, the livelihoods of American farmers, the safety of workers, and our own environment. The movie reveals how a handful of corporations control our nation’s food supply. Though the companies try to maintain the myth that our food still comes from farms with red barns and white picket fences, our food is actually raised on massive “factory farms” and processed in mega industrial plants. The animals grow fatter faster and are designed to fit the machines that slaughter them. Tomatoes are bred to be shipped without bruising and to stay edible for months. The system is highly productive, and Americans are spending less on food than ever before. But, the film asks, at what cost? Cattle are given feed that their bodies are not biologically designed to digest, resulting in new strains of E. coli bacteria, which […]

(Beyond Pesticides, June 25, 2009) Although it is known that infants are more susceptible than adults to the toxic effects of pesticides, this increased vulnerability may extend much longer into childhood than expected, according to a new study by researchers at the University of California, Berkeley. Among newborns, levels of paraoxonase 1 (PON1), an enzyme critical to the detoxification of organophosphate pesticides, average one-third or less than those of the babies’ mothers. It was thought that PON1 enzyme activity in children approached adult levels by age two, but instead, the UC Berkeley researchers found that the enzyme level remained low in some individuals through age seven. Based upon the findings, reported in the journal Environmental Health Perspectives, the study authors recommend that the U.S. Environmental Protection Agency (EPA) re-evaluate the current standards for acceptable levels of pesticide exposure. “Current EPA standards of exposure for some pesticides assume children are three to five times more susceptible than adults, and for other pesticides the standards assume no difference,” said Nina Holland, Ph.D., UC Berkeley adjunct professor of environmental health sciences and senior author of the paper. “Our study is the first to show quantitatively that young children may be more susceptible to […]