(Beyond Pesticides, February 5, 2008) Whether you love it or hate it, Valentine’s Day is less than ten days away. Millions of flowers and chocolates will soon be bought and given to loved ones. Unfortunately, these gifts come at a cost much higher than the one on the price tag. Conventional roses and chocolate sold in the United States are produced using toxic pesticides, with little regard for the workers or the environment.The United States imports about 70 percent of its flowers from foreign countries, mostly from Ecuador and Columbia. Roses analyzed in the past few years were found to contain a myriad of harmful pesticides that ranged from organophosphates such as Dimethoate, carbamate- Aldicarb, to organochlorines like Captan, Bravo, Tedion, Iprodione and Procymidone. Organophosphates are considered to be the most likely pesticide to cause an acute poisoning. They are a highly toxic class of pesticides that affect the central nervous, cardiovascular and respiratory systems. Symptoms of exposure include: numbness, tingling sensations, headache, dizziness, tremors, nausea, abdominal cramps, sweating, incoordination, blurred vision, difficulty breathing, slow heartbeat, unconsciousness, incontinence, convulsions and fatality. Some organophosphates have been linked to birth defects and cancer. Organochlorines are known estrogenic pesticides and have been linked […]

(Beyond Pesticides, January 31, 2008) A study to be published in the February 2008 issue of Environmental Health Perspectives finds that children who eat a conventional diet of food produced with chemical-intensive practices carry residues of organophosate pesticides that are reduced or eliminated when they switch to an organic diet. The study is entitled “Dietary Intake and Its Contribution to Longitudinal Organophosphorus Pesticide Exposure in Urban/Suburban Children” (Chensheng Lu, Dana B. Barr, Melanie A. Pearson, and Lance A. Waller) and includes authors from Rollins School of Public Health, Emory University, and the National Center for Environmental Health, Centers for Disease Control and Prevention.According to the authors, “The objective of this article is to present the data of assessing young urban/suburban children’s longitudinal exposure to OP [organophosphate] pesticides in a group [of] young children participating in the Children Pesticide Exposure Study (CPES). The results from this study identify not only the predominant source of OP pesticide exposure but also the profile of exposures in children that are vital in formulating the strategies, both from the regulatory policy and personal behavior change perspectives, in reducing children’s exposures to OP pesticides.” The study design included 23 children, male and female, from the Seattle […]

(Beyond Pesticides, January 30, 2008) A survey of 31 Australian strawberry growers conducted by a consumer watchdog revealed that almost all conventionally grown strawberries contained residues of pesticides. Several samples of the strawberries tested contained pesticide residues that exceeded the legal limit, and some even tested positive for pesticides banned for use on strawberries.Tests revealed that that 17 of the 27 samples of conventionally grown strawberries registered residues of at least two types of pesticide or fungicide. Four samples had traces of four different chemicals on the skin that had penetrated the fruit’s flesh as well. Choice, the chemical watchdog group that commissioned the survey, described the findings as alarming and calls on the Australian Government to remedy years of neglect over pesticide regulation, and to require independent, mandatory testing of all fruits and vegetables. “Analysis shows strawberries are more likely to have pesticide residues than other fresh fruit, and washing does not necessarily remove them,” said Choice spokesman Christopher Zinn. “Strawberries contain lots of nutrients but unfortunately they also tend to contain residues of pesticide”¦ [T]here are some concerns about long-term exposure to a mixture of different pesticides.” Jo Immig, the coordinator of National Toxics Network Inc, said the […]

(Beyond Pesticides, January 29, 2008) University of Cambridge scientists say there may be a link between persistent organic pollutants (POPs), including pesticides, and Type 2 Diabetes. The Cambridge scientists are advocating additional research into the little understood links between environmental pollution and adult onset diabetes. In the most recent edition of the journal Lancet, Oliver Jones, Ph.D., and Julian Griffin, Ph.D., highlight the need to research the possible link between persistent organic pollutants (POPs, a group which includes many pesticides) and insulin resistance, which can lead to adult onset diabetes. In their commentary, Dr. Jones and Dr. Griffin cite peer reviewed research including that of D. Lee, et al, which demonstrated a very strong relationship between the levels of POPs in blood, particularly organochlorine compounds, and the risk of type 2 diabetes. “Of course correlation does not automatically imply causation,” says Dr. Jones. “But if there is indeed a link, the health implications could be tremendous. At present there is very limited information. Research into adult onset diabetes currently focuses on genetics and obesity; there has been almost no consideration for the possible influence of environmental factors such as pollution.” Interestingly, in the Lee study an association between obesity and […]

(Beyond Pesticides, January 28, 2008) Reclaiming Our Healthy Future: Political change to protect the next generation, the 26th National Pesticide Forum, will be held March 14-16 at the University of California, Berkeley. Register now to pay the pre-registration rate. Recent speaker additions include Marla Cone, author of Silent Snow and environmental journalist with the Los Angles Times; Paul Saoke, executive director of Physicians for Social Responsibility Kenya; and Ted Schettler MD, science director of the Science and Environmental Health Network. These speakers will be joining a line-up which already includes Arturo Rodriguez (UFW President), Devra Davis, Ph.D. (author and University of Pittsburgh professor of epidemiology) and Tyrone Hayes, Ph.D. (UC Berkeley professor of integrative biology). Also, actress Kaiulani Lee will perform A Sense of Wonder, her one-woman play based on the life and works of Rachel Carson. The conference themes are pesticides and health with a particular focus on  children and workers, a vision for a just and sustainable food system, and creating political change. A tentative schedule of events is now available on the Forum webpage. Marla Cone is one of the nation’s premier environmental journalists. She has 22 years of experience covering environmental issues, including 18 years at […]

(Beyond Pesticides, January 23, 2008) Agribusiness giants Dow AgroSciences and Monsanto have successfully persuaded the state of Minnesota to reconsider their water-quality limit for the chemical, acetochlor. Scientists representing the industry presented their own studies to the Minnesota Pollution Control Agency (MPCA) and explained that the state’s original draft limit for acetochlor was too strict. Despite three years of research conducted by the state, scientists from Dow and Monsanto presented officials at the MCPA with six published studies- one of them in Chinese- which they claimed were overlooked by the state when determining the standard for acetochlor in waterways. As a result, the MPCA has decided to allow 3.6 parts per billion of acetochlor in rivers, more than twice the concentration of the 1.7 parts per billion previously proposed. As a result, three of five streams classified as ”˜impaired’ by acetochlor, including a popular trout stream in southeastern Minnesota, can no longer be considered polluted. Some environmental advocacy groups question whether the MPCA gave favorable treatment to the pesticide makers, claiming that other research that suggest that the chemical can cause ecological damage have not been seriously considered. “It looks like there’s a double standard, that industry can come in […]

(Beyond Pesticides, January 22, 2008) Triclosan, a very common antibacterial chemical, is present in the plasma and breast milk of nursing mothers, according to a study by Swedish researchers. Every one of the 36 mothers tested positive for triclosan levels in their bodies, and the concentrations were clearly and significantly higher in the exposed group (i.e., those that use triclosan-containing products) than in the control group. This does not come as a surprise since triclosan is widely used in personal care products””including soaps, deodorants, and toothpaste””as well as plastics and textiles. Although there was high variability within groups, even members of the control group had triclosan present in their plasma, indicating that there are other significant sources of exposure outside of hygiene products. Triclosan is not removed from wastewater by conventional treatment processes and has been found in both wastewater effluent and sewage sludge. The authors of Triclosan in plasma and milk from Swedish nursing mothers and their exposure via personal care products say that the significance of the presence of triclosan in plasma and breast milk of nursing mothers is not easily deduced and that the health effects, especially the long-term effects of chronic exposure, of triclosan are not […]

(Beyond Pesticides, January 14, 2008) Researchers at the Indian Institute of Technology (IIT) Madras have developed nanoparticles that can remove organochlorine pesticides from drinking water. These chemicals are quite persistent in the environment and difficult to remove from water. Notorious organochlorines include DDT, endosulfan, HCH (hexacholorcyclohexane) and aldrin, all of which have known health and/or environmental hazards. Many of these chemical pesticides are used heavily in agriculture and taint India’s water. Though no comprehensive national survey has been done, isolated studies show contamination of groundwater and river systems that cannot be removed by standard water filters. “Even though some of these pesticides have been banned, they are very much present in the environment. For instance, endosulfan has an environmental lifetime of 100 years,” said Thalappil Pradeep, professor of chemistry at IIT Madras. He leads the research that has shown that nanoparticles, mostly from gold, silver, copper and several oxides, are effective at removing endosulfan even at very low concentration. “Efficient chemistry at low concentration is important so that even if one molecule of the pesticide passes by, it gets removed by the nanoparticle,” said Pradeep. He holds a US and an Indian patent and has licensed part of the technology […]

(Beyond Pesticides, January 10, 2007) EPA decided at the end of 2007 to extend the deadline for public comments on its controversial proposal to allow pesticide product labels with third-party endorsements and cause-marketing claims. The new due date is March 27, 2008. The agency extended the public comment period for another 90 days in response to requests from Beyond Pesticides and others. In extending the comment, Debra Edwards, Director, Office of Pesticide Programs, said, “The Agency is particularly interested in assuring that its State partners in pesticide regulations, as well as organizations such as yours, have adequate opportunity for comments.” See letter.The issue of cause-marketing on pesticide labels came up last year when Clorox petitioned EPA to allow it to display the Red Cross logo on some of its products, including pine-sol and bleach products. In letters to all the state pesticide regulatory agencies in March, 2007, Beyond Pesticides urged the states to deny the label changes approved by EPA, saying: The inherent danger is that misleading the public about pesticides can result in harm to consumers who either do not, unfortunately, take the time to read pesticide labels or who cannot read or comprehend labels (e.g. non-English speaking citizens, […]

(Beyond Pesticides, January 9, 2008) Triclocarban, an antibacterial compound widely used as an additive to a range of household and personal care products including bar soaps, detergents, body washes, cleansing lotions, and wipes, has been found to have an amplification effect on the activity of natural hormones, which in turn can lead to adverse reproductive and developmental effects. In the study, published online November 29, 2007 in Endocrinology, researchers from University of California- Davis and Yale University investigated the endocrine disrupting properties of triclocarban and other polychlorinated diphenyl urea compounds by exposing human cells and rats to levels similar to those found in people. Triclocarban was found to have a synergistic interaction with the sex hormone, testosterone- present in both males and females. This interaction produced a positive, amplified biological effect, which is likely to hyperstimulate native sex hormones. This amplification of sex hormone activity occurs at the target cell and can result in developmental defects or decreased reproductive function. Researchers further explained that ovulation and ovarian function in females can be disrupted, while sperm quality can be decreased in males. The researchers also point out that the results of their study create a new category for endocrine disruptive substances […]

(Beyond Pesticides, January 8, 2008) Reclaiming Our Healthy Future: Political change to protect the next generation, the 26th National Pesticide Forum, will be held March 14-16 at the University of California, Berkeley. Register now to pay the pre-registration rate. James Roberts, M.D., associate professor of pediatrics at the Medical University of South Carolina and co-author of Recognition and Management of Pesticide Poisonings, and Jim Riddle, outreach coordinator for the University of Minnesota Organic Ecology program, have recently been added to the program. Previously announced speakers include Arturo Rodriguez (UFW President), Devra Davis, Ph.D. (author and University of Pittsburgh professor of epidemiology) and Tyrone Hayes, Ph.D. (UC Berkeley professor of integrative biology). Also, actress Kaiulani Lee will perform A Sense of Wonder, her one-woman play based on the life and works of Rachel Carson. Session topics include: Children’s health and public policy; Farmworker justice, organizing and consumer action; Building just and healthy food systems; Power of local activism to influence political change; Pesticides and the secret history of the war on cancer; Skills training sessions; DDT and malaria; Global warming and biofuels; Biomonitoring and pesticide drift; Lawns and landscapes; Managing indoor environments; Water quality and much more. Jim Riddle is outreach […]

(Beyond Pesticides, January 7, 2008) Sri Lanka started restricting the use of paraquat at the start of the new year and plans to have the herbicide completely banned within the next three years. According to Assistant Director of Agriculture K.B. Gunarathne, the decision was made in response to “the high rate of deaths due to paraquat poisoning caused by its inherent toxic properties.” Four to five hundred Sri Lankans die as a result of paraquat poisoning each year, and misuse of the herbicide is especially high in farming communities. Most paraquat poisonings occur as impulsive injections of chemical stored in or near the home, and injection of paraquat has a mortality around 65%, much higher than other agrochemicals. Also unlike other agrochemicals, Paraquat has no proven antidotes, and supportive care is relatively ineffective at preventing death. A substantial reduction of poisoning deaths is unlikely to be achieved by focusing solely on in hospital care. Sri Lanka will phase out paraquat in a series of steps, the first of which took place on January 1, 2008. Starting this year, the maximum concentration of paraquat ions in paraquat formulations will be 6.5%. In October 2006, the Pesticide Registrar mandated a reduction in […]

(Beyond Pesticides, January 4, 2008) A study appearing in the January 2, 2008 issue of the American Journal of Respiratory and Critical Care Medicine has found a correlation between women’s exposure to farm pesticides and allergic asthma. The study’s lead author, Jane Hoppin, Sc.D., of the National Institute of Environmental Health Sciences, cited the lack of information on the risks incurred when women apply pesticides, saying, “Farm women are an understudied occupational group.” The study evaluated data on 25,814 farm women who are participating in the Agricultural Health Study in Iowa and North Carolina. “This is the largest study of farmers and their families in the world, so it gives us an opportunity to look at diseases that haven’t been well characterized,” said Dr. Hoppin. The women self-reported their doctor-diagnosed asthma, and the team separated them into subgroups of allergic and non-allergic asthmatics. They also found that more than half of the responders had used or been exposed to pesticides, while 61 percent grew up on a farm. The resulting data found that use of pesticides increased risk of allergic asthma by almost 50 percent, but not of non-allergic. Where a woman grew up also affected her likelihood to develop […]

(Beyond Pesticides, January 3, 2008) The US Department of Agriculture (USDA) has struck an arrangement with agribusiness giant Monsanto Co. that gives farmers in four states a break on federal crop insurance premiums if they plant a majority of Monsanto-brand seed corn this spring. Farmers in Illinois, Indiana, Iowa and Minnesota need to plant 75-80% of their crops with Monsanto’s (and only Monsanto’s) GM seeds to receive the “premium rate discount”. The arrangement has raised some eyebrows, particularly among organic farm groups that argue the government agency should not be promoting corn that promotes herbicide use; the Monsanto brands are resistant to Roundup (main ingredient, glyphosate) and contain chemicals that kill insects and other plants. Monsanto’s deal is legal, according to USDA officials, who point out that such arrangements were encouraged in a 2000 crop insurance passed by Congress. The idea is to give farmers a break on their insurance premiums if they use corn seeds that are higher yield and show resistance to insects and other threats. USDA officials said they are aware of the appearance of favoritism toward one of the nation’s largest agricultural companies. “We knew it would look that way,” said Shirley Pugh, a spokeswoman for […]

(Beyond Pesticides, December 19, 2007) Maine Governor John Baldacci’s 2008 legislative packet is set to include recommendations made by the task force he commissioned to develop safer alternatives to hazardous chemicals in consumer goods and services. The Task Force to Promote Safer Chemicals in Consumer Products, submitted its report on Monday after a 16 month study identifying chemicals that should be phased out of Maine households and businesses. Governor Baldacci plans to submit a bill incorporating task force recommendations to develop a comprehensive chemicals policy focusing on the safety of consumer products. Among the findings of the 13-member task force, which was commissioned in February 2006, was a lack of federal regulation to ensure consumers have access to environmentally safe products, and health costs that have spiked in part to exposure to chemicals such as lead and pesticides, the use of which has tripled in Maine in the past 15 years. These chemicals, the report says present “significant risk of adverse health consequences ranging from subtle cognitive development to chronic disease and premature death.” Currently, there are more than 8,900 pesticidal products that can be legally applied in Maine, and about 431 confirmed cases of exposure to pesticides were reported […]

(Beyond Pesticides, December 18, 2007) According to a study published December 11, 2007 in the online edition of Environmental Health Perspectives, banning lindane is a viable solution to protecting health and the environment without resulting in increasing problems with head lice and scabies. In 2002, California banned pharmaceutical use of lindane due to concerns about water quality, when high levels of this treatment for head lice and scabies were found to be impacting wastewater quality. The study, “Outcomes of the California Ban on Pharmaceutical Lindane: Clinical and Ecologic Impacts,” describes the effects the ban has had on wastewater quality, unintentional exposures, and clinical practice. This is the first time that a pharmaceutical has been outlawed to protect water quality. As such, this ban provides a rare opportunity to evaluate the possible or potential outcomes of future public health interventions aimed at reducing pharmaceutical water contamination. The study authors compiled data on lindane in wastewater treatment plant effluent for several large plants in California and one outside of California. Data on exposures to lindane were obtained from records of the California Poison Control System. The impact on clinical practice was assessed via a survey of 400 pediatricians. Wastewater treatment plant monitoring […]

(Beyond Pesticides, December 17, 2007) People exposed to banned organochlorine pesticides and other toxic chemicals that persist in the environment are more likely to develop non-Hodgkin lymphoma (NHL), according to new research funded by the British Columbia Cancer Agency. The study, “Organochlorines and risk of non-Hodgkin lymphoma”, was published in the International Journal of Cancer on December 15, 2007 and is so far the largest to examine organochlorines in plasma and their link to illness. The researchers measured the levels of pesticides or pesticide metabolites and congeners of polychlorinated biphenyls (PCBs) in the blood of 880 British Columbians, half with NHL and the other half control subjects. Several pesticide analytes and a number of congeners showed a significant association with NHL. Non-Hodgkin lymphoma is the fifth most common cancer in Canada and the most common type of lymphoma. “We know that the incidence of non-Hodgkin lymphoma has been steadily rising for the past 30 years worldwide, but there hasn’t been clear evidence to explain the increase,” says Dr. John Spinelli, Ph.D., lead author and a senior scientist at the BC Cancer Agency. “Our study helps to provide answers to this puzzle by showing a strong link between these specific environmental […]

(Beyond Pesticides, December 14, 2007) A study recently published in Environmental Health Perspectives has found concentrations of the antibacterial chemical triclosan in a high percentage of subjects tested. Used in common household products like plastics, personal care products, and textiles, exposure routes are becoming difficult to avoid. According to the report’s summary, “Concentrations differed by age and socioeconomic status but not by race/ethnicity and sex. Specifically, the concentrations of triclosan appeared to be highest during the third decade of life and among people with the highest household incomes.” The study analyzed urine samples from 2,517 individuals, age 6 and over. Annual household income ranged from less than $5,000 to $75,000, and three major self-reported racial/ethnic groups were non-Hispanic black, non-Hispanic white, and Mexican American. Of the 2,517 urine samples, 74.6 percent contained triclosan. However, “the frequency of detection of triclosan varied by income group (63.7% [$20,000-$45,000]; 78.7% [$45,000]).” The report discussed the high levels of detection: “We detected concentrations of free plusconjugated species of triclosan in urine in 74.6% of the samples examined. This high frequency of detection is most likely associated with daily use by the US general population of consumer products that contain triclosan, including at least one […]

(Beyond Pesticides, December 12, 2007) On December 5, 2007, the US Environmental Protection Agency (EPA) denied the petition filed on June 2, 2006, by the Natural Resources Defense Council (NRDC) to revoke pesticide tolerances for dichlorvos (DDVP) established under Section 408 of the Federal Food, Drug, and Cosmetic Act, finding the petition to be “without merit.” According to the petition filed, the NRDC asserted that DDVP tolerances are unsafe and should be revoked for numerous reasons, including: (1) EPA has improperly assessed the toxicity of DDVP; (2) EPA has erred in estimating dietary and residential exposure to DDVP; and (3) EPA has unlawfully removed the additional safety factor for the protection of infants and children. The EPA, in its response says that the toxicity of DDVP is not a sufficient ground for seeking revocation of tolerances. NRDC’s petition argued that DDVP should not have been downgraded from “probable human carcinogen” to “possible human carcinogen.” But EPA found the studies cited to be inadequate to support an amendment in classification, and as such the petition to revoke tolerances to the extent based on the alleged cancer misclassification of DDVP was rejected. The petition also challenged that various exposure studies used to […]

(Beyond Pesticides, December 11, 2007) Arturo Rodriguez (UFW President), Devra Davis, Ph.D. (author and University of Pittsburgh professor of epidemiology) and Tyrone Hayes, Ph.D. (UC Berkeley professor of integrative biology) will be speaking at the 2008 National Pesticide Forum. The conference, Reclaiming Our Healthy Future: Political change to protect the next generation, will be held March 14-16, 2008 at the University of California, Berkeley. A native of Texas, Arturo S. Rodriguez has worked tirelessly to continue the legacy of Cesar Chavez since taking over the helm of the United Farm Workers of America (UFW) upon the death of its legendary founder in 1993. Beyond winning fair contracts for its workers, the UFW continues to work to protect farmworkers from pesticides and other workplace hazards. Recent union victories are agreements with Gallo Vineyards Inc. and Coastal Berry Co., the largest winery and the largest strawberry employer in the U.S., as well as pacts protecting winery workers in Washington and mushroom workers in Florida. Devra Davis, Ph.D., a renowned environmental health expert, is professor of epidemiology at the University of Pittsburgh Graduate School of Public Health. Dr. Davis was designated a National Book Award Finalist for her book, When Smoke Ran Like […]

(Beyond Pesticides, December 6, 2007) A study published in Environmental Health Perspectives this month finds that children born to mothers living in households with pesticide use during pregnancy have over twice as much risk of getting cancer, specifically acute leukemia (AL) or non-Hodgkin lymphoma (NHL). The study, Household Exposure to Pesticides and Risk of Childhood Hematopoietic Malignancies: The ESCALE Study (SFCE), 115:1787—1793 (2007) , investigates the role of household exposure to pesticides in the etiology of childhood hematopoietic malignancies, using the national registry-based case—control study ESCALE (Etude sur les cancers de l’enfant) that was carried out in France over the period 2003—2004. The researchers evaluated maternal household use of pesticides during pregnancy and paternal use during pregnancy or childhood which was reported by the mothers in a structured telephone questionnaire. Insecticides (used at home, on pets or for garden crops), herbicides and fungicides were distinguished. The researchers estimated odds ratios (ORs) using unconditional regression models closely adjusting for age, sex, degree of urbanization, and type of housing (flat or house). The researchers included a total of 764 cases of acute leukemia (AL), 130 of Hodgkin lymphoma (HL), 166 of non-Hodgkin lymphoma (NHL) , and 1,681 controls. Insecticide use during pregnancy […]

(Beyond Pesticides, December 4, 2007) On November 29, 2007, the California Department of Pesticide Regulation (DPR) reported 2006 pesticide use statistics that showed continued progress toward less pesticide use statewide. However, strawberry growers increased their reliance the highly toxic, ozone depleting fumigant methyl bromide. Overall statewide pesticide use declined by nearly six million pounds from 2005 to 2006 (from 195.3 million to 189.6 million). While use increased in landscape maintenance, public health and other categories, production agriculture saw a 10 million pound drop. Use of many high-toxicity chemicals, including carcinogens, neurotoxic pesticides and chemicals linked to reproductive effects dropped for the third consecutive year. “DPR works hard to promote least-toxic pest management, and our efforts are paying off,” said DPR director Mary-Ann Warmerdam. “At the same time, we will continue to strive for long-term success in pest management, and we have more work to do.” On the other hand, the Los Angeles Times reports that state strawberry growers, primarily around Oxnard and in the Salinas and Watsonville areas, applied fumigants to 5,000 more acres, using 132 more tons of the chemicals than in the previous year. That is a 9% increase in acreage treated and a 3% increase in tonnage. […]

(Beyond Pesticides, November 28, 2007) Researchers at the Centers for Disease Control (CDC) have determined that previous studies that assessed population-based exposure to atrazine were significantly and systematically underestimated. The CDC relies on the detection and analysis of only one of the twelve identified metabolites of atrazine measured in human urine samples to estimate exposure. However, after looking at multiple metabolites, researchers found that previous assessments missed most of the exposure. Atrazine mercapturate (AM), a metabolite of atrazine, was used as definitive evidence of direct atrazine exposure. General population data indicated that less than 5% of the population was exposed to atrazine-related chemicals. However, researchers at the CDC found that this research, which relied on AM detection, gives a low and misleading estimate of exposure to atrazine and atrazine- related metabolites. Published in Environmental Health and Perspectives and entitled “Assessing Exposure to Atrazine and Its Metabolites Using Biomonitoring”, the small-scale study involving 24 individuals measured nine atrazine-related metabolites in urine. The sample was organized with respect to how likely the individuals were to be exposed to atrazine: (1) high exposure (turf pesticide applicators), (2) low exposure (non-occupationally exposed people in whom atrazine mercapturate was found during a prior study) and […]