(Beyond Pesticides, March 24, 2026) Published in Environmental Pollution, study results in the floriculture region of Ecuador find detections of neonicotinoid insecticides (NNI) and the herbicide atrazine in drinking and irrigation water. The biomonitoring data reported in an earlier journal article in the same region found a total of 23 compounds used as herbicides, insecticides, and fungicides, their associated metabolites (breakdown products), which include organophosphates, pyrethroids, and neonicotinoids. (See Daily News here.) Researchers from the University of Iowa, University of California, San Diego State University, and Universidad de San Francisco in Quito, Ecuador, determined that 1 in 5 households (20.5%) have detectable levels of one or more neonicotinoids in drinking water samples surrounding floricultural agricultural operations. This builds on previous research underscoring the nontarget pesticidal effects in communities near agricultural operations where the chemicals drift through the air and move into soil and water. Methodology and Results The authors report that, “This study focused on household tap water in proximity to floricultural plantations and in the ESPINA [Secondary Exposures to Pesticides among Children and Adolescents] participants’ homes with a range of NNI and total pesticides in urinary metabolite samples of the children.” They continue: “Participant households in the water study were […]

(Beyond Pesticides, March 23, 2026) After President Trump invoked the Defense Production Act of 1950 and issued an Executive Order (EO), Promoting the National Defense by Ensuring an Adequate Supply of Elemental Phosphorus and Glyphosate-Based Herbicides, U.S. Representatives Thomas Massie (R-KY) and Chellie Pingree (D-ME) stood up to say “no.” They introduced the No Immunity for Glyphosate Act (HR 7601) to undo the February 18 Executive Order, which is now being supported by a campaign to urge Congressional Representatives to cosponsor the bill.  With the EO’s declaration that contains no supporting documentation or findings, the U.S. government is granting Bayer/Monsanto immunity from lawsuits for adverse health effects or damage associated with the production, transportation, use, and disposal of the weed killer glyphosate. The executive order proclaims: “There is no direct one-for-one chemical alternative to glyphosate-based herbicides. Lack of access to glyphosate-based herbicides would critically jeopardize agricultural productivity, adding pressure to the domestic food system, and may result in a transition of cropland to other uses due to low productivity.  Given the profit margins growers currently face, any major restrictions in access to glyphosate-based herbicides would result in economic losses for growers and make it untenable for them to meet growing food and feed demands.” […]

(Beyond Pesticides, March 20, 2026) Biopesticides represent a kind of Utopian destination in the landscape of agricultural sustainability. If only they could ensure planetary harmony. A review of botanical biopesticides in the March 11 issue of Toxics raises important questions that require scrutiny and review under the pesticide registration process and when used in organic systems under the Organic Foods Production Act. The term biopesticide can be misleading, and any replacements for synthetic pesticides cannot be taken only on faith. As Beyond Pesticides has noted previously, the U.S. Environmental Protection Agency’s (EPA) definition of biopesticides—“derived from such natural materials as animals, plants, bacteria, and certain minerals”—is broad, vague, and used differently by different interests. EPA regulates biopesticides under the Federal Insecticide, Fungicide, and Rodenticide Act (FIFRA) in three categories: Substances that interfere with mating, such as insect sex pheromones, as well as various scented plant extracts that attract insect pests to traps; Microbial pesticides consisting of a microorganism (e.g., a bacterium, fungus, virus, or protozoan) as the active ingredient; and Plant-Incorporated-Protectants (PIPs), pesticidal substances that plants are genetically engineered to produce. The review by Sandra Petrovic, PhD, and Andreja Leskovac, PhD, of the University of Belgrade, highlights the need not to […]

(Beyond Pesticides, March 19, 2026) A study of water contamination in Protected Areas (PAs) in Brazil, published in Science of The Total Environment, highlights the pervasiveness of pesticides. “Our objective was to evaluate the effectiveness of these PAs in mitigating pesticide contamination in watercourses and to investigate how land use patterns influence the presence of pesticide residues,” the authors state. “We found pesticide compounds in biofilms [mutually beneficial community of microorganisms] both inside and outside PAs’ streams, with no buffer effect of these protected lands against herbicides, insecticides and fungicides, contrary to our expectations.” In analyzing epilithic biofilms, which are communities of microorganisms that adhere to submerged rocks and surfaces in aquatic ecosystems, the researchers find residues of 14 pesticide compounds and one metabolite across the 19 sampling sites, threatening aquatic organisms and ecosystem functioning. The authors say, “[M]onitoring epilithic biofilms in PAs provides valuable information by detecting pesticide compounds that analysis of surface water and sediments might miss.” Through various routes, such as runoff to waterways, leaching into groundwater, and aerial drift, pesticides are ubiquitous in the environment, even in remote and protected areas. As the testing of the freshwater epilithic biofilms in this study reveals 15 pesticide residues […]

(Beyond Pesticides, March 18, 2026) Researchers in Germany and Brazil investigated the biodiversity of agricultural landscapes in organic and non-organic areas in “bee hotels,” finding that there is a positive correlation between organically managed fields and numerous indicators of improved pollinator health, including an “increase in bee abundance, species richness, and diversity.” This study, published in Global Ecology and Conservation, builds on the breadth of existing research in recent years that underscores the adverse public health and biodiversity effects associated with a food system that is drenched in synthetic chemicals, as well as additional evidence of the ecological and economic benefits of organic agriculture. Methodology and Results Research for this study “was conducted at 17 sites in the southern part of Germany, Baden-Württemberg, including eight conventional and nine organic farming systems.” Researchers for this study are based at the Institute of Evolutionary Ecology and Conservation Genomics at Ulm University in Germany and the Laboratory for Bee Studies at the Federal University of Maranhão in São Luís, Maranhão in Brazil. The authors signed a “declaration of competing interest,” stipulating that “that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in […]

(Beyond Pesticides, March 17, 2026) An article in Microorganisms by researchers from the U.S., Israel, and Australia analyzes the adverse health and environmental effects of genetic engineering and genetically modified organisms (GMOs), specifically genetically modified microorganisms (GMMs). As the authors state, the prevalence of genetic engineering has “accelerated the creation and large-scale environmental release” of GMMs, which “present unique, long-term risks to human and environmental health.” One of the authors, André Leu, DSc, spoke at the first session of Beyond Pesticides’ National Forum Series: Forging a Future with Nature in 2023. (See recording here.) This review provides risk scenarios of GMMs, showing the threat to ecological systems, particularly within the soil, and human health. As GMMs are “biologically active, self-replicating entities capable of rapid mutation and global dispersal” they present greater risks, and current regulatory frameworks do not adequately assess their potential harm. Genetically altering microorganisms, the most complex and diverse systems in biology, and creating new gene combinations with unknown implications, “has the potential to disrupt the functions, diversity, interactions, and impacts of microbes and microbiomes,” the researchers note. They continue: “This puts human and environmental health at risk. Worst-case scenarios include the promotion of diseases, risks to species […]

(Beyond Pesticides, March 16, 2026) On the brink of the first genetically engineered (GE) wheat to be introduced into the U.S. market, after the U.S. Department of Agriculture (USDA) approved it in August, 2024, groups are calling on Congress to instruct USDA to prohibit HB4 wheat and instruct EPA to prohibit the use of glufosinate herbicides on wheat. The herbicide on which the crop is dependent, glufosinate, is a highly toxic herbicide banned in the European Union because of its links to reproductive and developmental harm. The drought- and herbicide-tolerant wheat, known as HB4 GMO wheat, follows a long line of genetically engineered crops that have been allowed to be grown in the U.S., with Roundup ReadyTM (glyphosate-tolerant) soybeans being among the first crops allowed in 1996. While the introduction of this technology promised to reduce pesticide use (herbicides are included under the definition of pesticide), the exact opposite occurred, with the skyrocketing of herbicide use. (See Daily News review of a study by Charles Benbrook, PhD, “Impacts of genetically engineered crops on pesticide use in the U.S.—the first sixteen years.”) The extraordinary increase in herbicide use associated with GE crops has been accompanied by an escalating increase in weed resistance […]

(Beyond Pesticides, March 13, 2026) In a press release on March 10, 2026, Public Employees for Environmental Responsibility (PEER) cites independent test data on the herbicide indaziflam with detections of per- and poly-fluoroalkyl substances (PFAS), the “forever chemicals” known for significant toxicity at low level exposure and high persistence. The product, Rejuvra™, is produced by Envu (a former division of Bayer) and “is being sprayed and considered for use across millions of acres of Bureau of Land Management (BLM) and US Forest Service land.” Scientific literature connects indaziflam and PFAS with adverse effects to human, soil, and biodiversity health, raising serious concerns about their wide use in agriculture and general land management of lawns, parks, playing fields, ornamentals, fence lines, rights-of-way, rangeland, open space, and Christmas trees. Background As a pre-emergent weed killer used to kill annual grasses and unwanted broadleaf plants, the fluoroalkyltriazine herbicide is broadly labeled for use in residential areas, commercial ornamental and sod production, forestry, and mostly orchard crops. While indaziflam is considered a “selective” herbicide, it actually kills and prevents germination of a wide range of broad-leaved plants and grasses and comes close to being a soil sterilant.  Since the chemical is subject to drift […]

(Beyond Pesticides, March 11, 2026) The Monsanto Company, founded in 1901 and acquired by the multinational corporation Bayer AG in 2018, submitted its opening brief to the Supreme Court of the U.S. (SCOTUS) last month, seeking liability immunity from lawsuits filed by product users who have been harmed but not warned about potential product hazards. The question before SCOTUS is: “Whether the Federal Insecticide, Fungicide, and Rodenticide Act, 7 U.S.C. 136 et seq., preempts a state-law failure-to-warn claim concerning a pesticide registered by the U.S. Environmental Protection Agency (EPA), where EPA has determined that a particular warning is not required and the warning cannot be added to a product label without EPA approval.” If successful, the Court would be overturning (reversing) its 2005 decision in Bates v. Dow Agrosciences, 544 U.S. 431, which upheld EPA and state registration of pesticides as a floor of protection, without releasing manufacturers of the responsibility to warn for potential harm that is not required by EPA. Pesticide manufacturers propose the text for their product labels and EPA ensures compliance with its minimum requirements, which does not preclude them from disclosing potential adverse effects they know of or should have known. The Missouri case before the Supreme Court, Durnell v. Monsanto, on the cancer causing effects of the weed killer glyphosate (RoundupTM) resulted in a jury verdict (in 2023) of $1.25 million and the total number of jury verdicts and settlements may amount to over $10 billion in liability if […]

(Beyond Pesticides, March 9, 2026) Policy and toxicology are slated to collide as the U.S. Environmental Protection Agency (EPA) considers allowing the use of a PFAS pesticide by invoking an emergency waiver process in federal pesticide law. If authorized, EPA’s decision will permit the use of an unregistered pesticide under an emergency waiver provision—in this case an emergency caused by weed resistance to weed killers (herbicides) on the market. EPA is accepting public comments until March 16, 11:59pm EDT. Beyond Pesticides is urging the public to object to EPA approval by writing to EPA and Congress stating that herbicide resistance is not an emergency and PFAS chemicals must not be broadcast in the environment.  The pesticide that is being requested for use is a new not yet registered, herbicide tetflupyrolimet (TFP), which is a PFAS chemical according to the definition of the Organisation for Economic Co-operation and Development (OECD). The fact that the chemical is not registered by EPA means that it has not been reviewed in accordance with all the safety assessments reviewed under the Federal Insecticide, Fungicide, and Rodenticide Act (FIFRA). The states applying for the exemptions under Section 18 of FIFRA—Missouri and Arkansas—claim that there is an emergency requiring the use of TFP because […]

(Beyond Pesticides, March 5, 2026) In a deep analysis of public records, U.S. Right to Know (USRTK), a nonprofit newsroom and public health research group, discloses significant financial ties between Bayer-Monsanto, lobbying firms, and the second Trump Administration, raising concerns about basic safeguards to curb corporate influence over federal policymakers. The USRTK tracker and report, “Tracing Bayer’s ties to power in Trump’s Washington,” (see more) finds that there have been significant lobbying investments by the multinational pesticide corporation just in the past year, including:  “At least $9.19 million on federal lobbying in [2025]”;   “16 key administration officials with ties to Bayer’s lobbying or legal network. Bayer and its lobbyists have access to people in power at the White House, U.S. Department of Agriculture, the Environmental Protection Agency and even those in high level positions closest to Trump”;  “45 people registered to lobby for Bayer under the Lobbying Disclosure Act, and at least 13 outside lobby firms – seven of which are now among the highest-paid firms in D.C”; and,  “More than 30 senior officials at lobby firms retained by Bayer have direct ties to Trump, having worked in one or both of his administrations or political campaigns.”  The report points out that the four main trade and […]

(Beyond Pesticides, March 4, 2026) In the International Journal of Epidemiology, researchers from France assess the risks of kidney cancer with a wide range of agricultural activities and tasks, finding that occupational exposure heightens kidney cancer risk. In studying participants from the French AGRIculture and CANcer cohort (AGRICAN) with incident kidney cancer, elevated risks of disease development between 25-56% are documented for both men and women engaging in agricultural activities. In men, the authors find increased kidney cancer in those “working with rapeseed and sunflowers, and tasks related to other crops such as corn, wheat/barley, beet, and tobacco.” In women, an increased risk is noted for winegrowers and corn growers. “Pesticide use (on fields and/or seeds) was associated, for both sexes, with these crops, showing exposure-response relationships with crop area and work duration,” the researchers state. This study, of a large cohort of agricultural workers, highlights the disproportionate risks of adverse kidney health to farmworkers directly handling pesticides or encountering pesticide residues on recently treated products. According to the World Cancer Research Fund, kidney cancer is the 14th most common cancer worldwide, affecting men more often than women. Kidney cancer incidence and mortality have increased globally, with various causes, such […]

(Beyond Pesticides, February 27, 2026) Researchers at Prairie View A&M University in Texas published in the journal Sustainability a study of organic agricultural systems from 1960 to 2021, concluding that “the outlook for U.S. organic fruit and vegetables is encouraging, supported by expanding consumer demand, government support, and improved conditions for international trade.” While delivering upbeat findings, including health benefits, the study identifies tremendous obstacles to entry into organic farming, including the limited support for alternative pest management and pest control systems in the United States in recent modern history, compared to the assistance provided for highly subsidized, petrochemical-dependent agricultural practices. Public health and environmental advocates continue to advocate for a wholesale transition to organic pest management, including calls for U.S. Representatives and Senators to cosponsor the Opportunities in Organic Act! Study Methodology, Background, and Findings The authors of this literature review arrived at the following conclusions on research trends for human health and environmental impacts of organic systems (for further analysis, the numbers below list citations from their report): “[O]rganic food has been documented to have higher antioxidant capacity, acidity, and phosphorus as well as lower levels of cadmium, pesticides, and other chemicals (18–22). Additionally, organic practices increase the […]

(Beyond Pesticides, February 26, 2026) Published in PLOS ONE, research in Brazil “analyzed the impact of occupational/household chronic exposure to pesticides on the clinicopathological profile of breast cancer in rural women from Paraná southwest, a predominantly rural landscape with large pesticide uses,” finding that “pesticide exposure favors the occurrence of more aggressive breast cancer.” The study highlights the disproportionate risks of pesticides to farmworkers, focusing on women, as it compares exposed and unexposed populations and breast cancer tumor/disease characteristics. One of the study authors, Carolina Panis, PhD, discussed her earlier research at the Beyond Pesticides’ 42nd National Forum Series, The Pesticide Threat to Environmental Health: Advancing Holistic Solutions Aligned with Nature. In her previous work, Pesticide exposure and increased breast cancer risk in women population studies, Dr. Panis documents a number of pesticides that “can increase the risk of BC [breast cancer] development through various mutagenic [genetic mutations] and nonmutagenic mechanisms and can act directly as carcinogens or indirectly as biochemical modifiers and hormonal deregulators. The underlying mechanisms include endocrine disruption; genotoxicity; epigenetic changes [changes to gene function without changing DNA]; enhanced cell migration, invasion, and…” more. Dr. Panis and other researchers at the Forum support community-level understanding of the […]

(Beyond Pesticides, February 25, 2026) Residues of the weed killer glyphosate, which has been classified as “probably carcinogenic to humans” by the International Agency for Research on Cancer, have been routinely found in food products, and a recent state survey in Florida confirmed previous findings. The findings are well within the legal standards for allowable residues. So, why is the Trump administration, in invoking the Defense Production Act of 1950 by Executive Order and its immunity-from-lawsuits provision for glyphosate manufacturers, concerned about glyphosate residues in food and other nondietary exposure? Could it have something to do with the over $10 billion in jury verdicts and settlements on glyphosate exposure against the manufacturer Bayer/Monsanto, with tens of thousands of cases pending, and the robust independent, peer-reviewed scientific findings that link glyphosate to non-Hodgkin lymphoma and a host of other adverse health effects? Nothing in the President’s executive order appears to meet the intent of the statute and its stated purpose to protect “the ability of the domestic industrial base to supply materials and services for the national defense and to prepare for and respond to military conflicts, natural or man-caused disasters, or acts of terrorism within the United States . . .” Without […]

(Beyond Pesticides, February 19, 2026) A study published in Scientific Reports highlights the benefits of organic agriculture in comparison to different farming systems over five years on four crops (maize, tomato, faba bean, and potato). “Soil carbon sequestration is a long-time storage of carbon in soil which represents 70% of the carbon in land,” the authors note. “Therefore, the main aim of this study is to investigate the effect of the agricultural practice systems on the soil carbon sequestration and properties, productivity, water consumption, soil carbon sequestration, CO2 emission and cost of some agricultural crops.” As a result, the experiment reveals that, compared to chemical-intensive farming, organic methods enhance soil properties, reduce water consumption, provide higher yields and higher soil carbon sequestration, reduce CO2 emissions, and achieve the highest total net profit for all four crops after five years. Study Importance The topic of food security and sustainable agricultural systems is a crucial one, particularly as environmental degradation escalates. “Recently, organic agricultural systems have drawn much attention as alternative ways to produce food and ensure security in terms of environmental sustainability,” the researchers say, while Beyond Pesticides and organic advocates have been discussing the viability of organic agriculture for decades. […]

(Beyond Pesticides, February 18, 2026) Research finds that widespread agricultural pesticide use increases chronic dietary exposure in poultry and leads to adverse reproductive effects, despite meeting legal residue limits. As published in Poultry Science by researchers in Poland, the study analyzes low-dose exposure of roosters (Gallus gallus domesticus) to the fungicide tebuconazole (TEB), the insecticide imidacloprid (IMI), and the weed killer glyphosate (GLP) individually and in mixtures, with all concentrations at or below the maximum residue limits (MRLs) established by the European Union (EU). “Sub-MRL pesticide exposure impaired male reproductive function, with the most pronounced effects observed following combined treatments,” the authors report. They continue: “[E]xposure resulted in reduced semen quality, decreased fertility and hatchability, and increased embryo mortality, particularly in groups receiving IMI alone or in combination. These functional impairments were accompanied by detectable pesticide residues in reproductive tissues and body fluids, as well as modulation [modification/alteration] of local and systemic immune parameters.” The results of the experiment highlight how combined pesticide exposure, resulting from common use of multiple pesticide active ingredients concurrently, produces “stronger and more persistent reproductive effects than individual compounds, indicating mixture-specific toxicity.” This study is particularly important, as it represents the chronic exposure to MRL-compliant […]

(Beyond Pesticides, February 13, 2026) In a novel, continent-wide study of soil biodiversity throughout Europe published in Nature, researchers find 70% of the sampled sites contain pesticide residues, which “emerged as the second strongest driver of soil biodiversity patterns after soil properties,” particularly in croplands. As soil biodiversity is key for ecosystem functioning, agricultural and land management practices that safeguard biodiversity are imperative. This study, however, highlights how pesticides alter microbial functions, including phosphorus and nitrogen cycling, and suppress beneficial taxa, such as arbuscular mycorrhizal fungi and bacterivore nematodes, and adds to a wide body of science that links pesticide residues in soil to adverse effects on biodiversity. In analyzing 373 sites across woodlands, grasslands, and croplands in 26 European countries, and examining the effects of 63 pesticides on soil archaea, bacteria, fungi, protists, nematodes, arthropods, and key functional gene groups, the data reveals “organism- and function-specific patterns, emphasizing complex and widespread non-target effects on soil biodiversity.” As the authors state, “[T]o our knowledge, ours is the first study to demonstrate the relative importance of pesticides in comparison to soil properties, ecosystem type and climate at a continental scale.” Study Importance As Kristin Ohlson describes in her book The Soil […]

(Beyond Pesticides, February 12, 2026) Editor’s Note. This is a piece about improving risk assessments and a proposal that could offer a more realistic characterization of the harm associated with the complexities of pesticide exposure. Beyond Pesticides notes that risk assessment methodology, unless it is considered in the context of a rigorous alternatives assessment, begins with the mostly false assumption that petrochemical pesticides are needed (or are essential) to achieve cost-effective pest management, agricultural productivity and profitability, and quality of life, when, in fact, this is not the case. Therefore, improved risk calculations—as the article being reviewed here proposes—while important to characterizing the harm and the unknown adverse effects associated with pesticide use, still impose some level of harm deemed by the government to be acceptable. Even worse, the adverse effects of exposure cannot be fully characterized because of uncertainties or a lack of data on harmful endpoints, as is the case currently with endocrine-disrupting pesticides not fully evaluated by the U.S. Environmental Protection Agency (EPA), California’s Department of Pesticide Regulation (DPR), or other regulatory bodies. These pesticides are known to induce cancer, reproductive harm, infertility, biodiversity decline, and other life-threatening, often multigenerational, effects. The authors do recognize the serious […]

(Beyond Pesticides, February 10, 2026) Species that are integral to pest management allow for crucial ecosystem services that negate the need for pesticides in agricultural or land management practices. In a study published in Agriculture, Ecosystems & Environment, researchers from France find pesticide-free fields promote carabid beetles and spiders, generalist arthropod predators that consume slugs, aphids, and mites, that in turn support healthy, organic systems. The study findings highlight the importance of utilizing farming practices that promote biodiversity and foster natural enemy populations as a pest management strategy.   “In this study, we assessed the assemblages of emerging and circulating ground-dwelling carabids and spiders during four months in a continuous mosaic of pesticide-free winter-sown crops under contrasted tillage regimes (minimum vs. conventional tillage) and sown flower strips bordering fields,” the authors describe. They continue: “We detected clear patterns, with high in-field carabid and spider overwintering densities than in adjacent flower strips… Our results also demonstrate the key role of pesticide-free fields under minimum tillage, acting both as a high-quality overwintering site for some dominant carabid species and as a source habitat, as several predator species activity-density responded positively to the increased area of minimum tillage fields in the surroundings.” Background […]

(Beyond Pesticides, February 9, 2026) Every year during the lead-up to Valentine’s Day, the story of pesticide-intensive practices in the flower industry is told. The hazards of pesticides used in flower production and their resulting residues are well-documented. At the same time, the benefits of flowers to one’s psychological well-being have been studied, with findings that suggest flowers are a positive stimulus for emotional well-being, beyond the beauty that they bring to a home, wedding, office, or hospital room. One scientific study shows that flowers perform a socio-emotional function, while a survey done by the American Society for Horticultural Science finds that, “Consumers consistently reported positive effects of cut flowers on mood, morale, and stress reduction.” People want to share this positivity through the giving of flowers, especially on Valentine’s Day. Despite these benefits, the few studies that have been conducted show elevated pesticide exposure for florists through inhalation and dermal absorption. Beyond Pesticides’ network, recognizing that flowers can be grown with organic practices, is asking EPA and Congress to eliminate pesticide use in flower production and resulting residues, while supporting the transition to organic management practices. Similar to food production, the organization says that health and the environment do not […]

[Update on February 9, 2026: In a press release on Friday, February 6, titled “EPA Implements Strongest Protections in Agency History for Over-the-Top Dicamba Use on Cotton and Soybeans for Next Two Growing Seasons,” the U.S. Environmental Protection Agency (EPA) continues to ignore the wide body of science that documents harms from dicamba, as well as the viability of alternative methods, in establishing what the agency is boasting are “the strongest protections in agency history for over-the-top (OTT) dicamba application on dicamba-tolerant cotton and soybean crops” as a direct response to the “strong advocacy of America’s cotton and soybean farmers.” These so-called “strong protections” are described as a way to ensure farmers can access the tools they “need” while also protecting the environment from dicamba’s harmful drift. In using “gold-standard science and radical transparency,” EPA created new label restrictions for the next two growing seasons that include “cutting the amount of dicamba that can be used annually in half, doubling required safety agents, requiring conservation practices to protect endangered species, and restricting applications during high temperatures when exposure and volatility risks increase.” Relying on unenforceable label restrictions and mitigation measures, however, fails to adequately protect health and the environment. See […]

(Beyond Pesticides, January 27, 2026) A three-part study published in Molecular Neurodegeneration draws a connection between Parkinson’s disease (PD) and the organophosphate chlorpyrifos. “Since chlorpyrifos (CPF) exposure has been implicated as a risk factor for PD, we investigated its association to incident PD and if this association is biologically plausible using human, rodent, and zebrafish (ZF) studies,” the researchers state. Together, the three experiments “strongly implicate exposure to CPF as a risk factor for developing PD,” as the authors find that exposure, even at very low concentrations, causes selective toxicity to dopaminergic neurons that are critical for functions of movement, cognition, emotion, and more. The results reveal that in humans, long-term residential exposure is associated with more than a 2.5-fold increased risk of developing PD, while exposure in mice causes “motor impairment, dopaminergic neuron loss, microglial activation, and an increase in pathological α-synuclein (α-syn) [proteins primarily found in the brain].” The researchers continue, “Using ZF, we found that CPF-induced dopaminergic neuron loss was at least partially due to autophagy dysfunction and synuclein accumulation, as knocking down LC3 [a protein chain] recapitulated the dopaminergic neuron loss.” These three studies highlight the association of CPF with increased risks for developing PD, as […]