(Beyond Pesticides, August 24, 2022) New research is helping the medical community understand the mechanism through which exposure to the banned insecticide DDT increases risk of Alzheimer’s disease. Published in the journal Environmental Health Perspectives, a team of researchers from Florida International University and Rutgers used multiple models to demonstrate the effects of DDT on the production of toxic proteins in the brain. The constant stream of new health risks regarding a chemical banned decades ago underlines the importance of a precautionary approach to pesticide regulation, particularly as red flags are already being raised about the connection between widely used weed killers like glyphosate and neurodegenerative diseases like Alzheimer’s. “The vast majority of research on the disease has been on genetics — and genetics are very important — but the genes that actually cause the disease are very rare,” says study coauthor Jason Richardson, PhD of Florida International University. “Environmental risk factors like exposure to DDT are modifiable. So, if we understand how DDT affects the brain, then perhaps we could target those mechanisms and help the people who have been highly exposed.” Previous research from Dr. Richardson found that DDT exposure increased risk of Alzheimer’s by four times. Scientists […]

(Beyond Pesticides, June 30, 2022) A study by Zhongnan University and Shandong University in China finds that the broad-spectrum fungicide maneb increases Parkinson’s disease (PD) risk and development through alterations in protein and metabolite pathways, resulting in neurotoxicity. Several studies find exposure to chemical toxicants, like pesticides, have neurotoxic effects or exacerbate preexisting chemical damage to the nervous system. Although the mechanism by which pesticides induce disease development remains unclear, this study suggests neurological damage from oxidative stress, cell dysfunction, and synapses impairment, among others, increases the incidence of PD subsequent to pesticide exposure. Parkinson’s disease is the second most common neurodegenerative disease, with at least one million Americans living with PD and about 50,000 new diagnoses annually. The disease affects 50 percent more men than women, and individuals with PD have a variety of symptoms, including loss of muscle control and trembling, anxiety and depression, constipation and urinary difficulties, dementia, and sleep disturbances. Over time, symptoms intensify, but there is no current cure for this fatal disease. While only 10 to 15 percent of PD cases are genetic, PD is quickly becoming the world’s fastest-growing brain disease. Therefore, research like this highlights the need to examine molecular mechanisms involved in altering chemical […]

(Beyond Pesticides, June 2, 2022) A California judge ordered state-run pesticide spraying to cease on public, agricultural, wild lands, and private properties. The judge states that government officials fail to consider and minimize the potential health and environmental risk associated with pesticide use. Moreover, officials failed to notify the public on the risks of pesticide spraying. The suit was brought by the Environmental Working Group (EWG), the City of Berkeley and ten other public health, conservation and food safety organizations, including Beyond Pesticides. Board member of the California Environmental Health Initiative Nan Wishner states, “The court made the right decision to throw out CDFA’s plan to cement into place for the indefinite future the agency’s ‘spray now, ask questions later approach to pest management, which would have perpetuated the existing situation, in which Californians learn their yards or neighborhoods are to be sprayed only when the treatments are about to happen and have little or no recourse to stop the use of pesticides.”  On May 19, 2022, the Superior Court of California – County of Sacramento ruled to remove an environmental impact report allowing California’s Department of Food and Agriculture (CDFA) to spray pesticides at any time and any place. Removal […]

(Beyond Pesticides, May 27, 2022) In a U.S. Environmental Protection Agency (EPA) court document filed on May 16, the agency signaled potential changes to the labeling it requires for “over the top” (OTT, or post-emergent) herbicides containing dicamba, a very problematic pesticide. The filing — in U.S. District Court for the District of Arizona, where EPA currently faces litigation about its 2020 dicamba registrations — comes as a result of Bayer, Inc.’s March 2022 proposed amendments to EPA registration for its XtendiMax herbicide, which contains dicamba and glyphosate. Beyond Pesticides has covered the dicamba saga for years, including the EPA Office of the Inspector General’s critical 2021 report citing an abandonment of science and assault on agency integrity for EPA’s dicamba decisions during the Trump years. Dicamba has been linked to cancer, reproductive effects, neurotoxicity, birth defects, and kidney and liver damage. It is toxic to birds, fish, and other aquatic organisms, and is known to leach into waterways after application. Dicamba also causes serious damage to non-GE (genetically engineered), non-target plants, damaging habitat and food sources for various organisms, especially for birds and insects. According to Progressive Farmer, EPA is currently considering some dicamba use restrictions after Bayer submitted them to […]

(Beyond Pesticides, May 26, 2022) A study published in The International Journal of Biochemistry & Cell Biology finds environmental exposure to neurotoxic pesticides increases Parkinson’s Disease (PD) risk through gastrointestinal (GI) disruption. Research finds exposure to chemical toxicants, like pesticides, can cause neurotoxic effects or exacerbate preexisting chemical damage to the nervous system. Although the mechanism by which pesticides induce disease development remains unclear, this study suggests environmental pesticide exposure disrupts GI cells responsible for supporting the autonomic nervous system. Enteric glial cells (EGCs) are GI cells that play a critical role in the functional changes that accompany GI dysfunction, as this dysfunction is one of the earliest symptoms indicating the onset of PD. Parkinson’s disease is the second most common neurodegenerative disease, with at least one million Americans living with PD and about 50,000 new diagnoses each year. The disease affects 50% more men than women, and individuals with PD have a variety of symptoms, including loss of muscle control and trembling, anxiety and depression, constipation and urinary difficulties, dementia, and sleep disturbances. Identifying early biomarkers of PD, such as pesticide-mediated toxicity on GI cells, is crucially important as symptoms intensify overtime, with no current cure for this fatal disease. While only […]

(Beyond Pesticides, May 24, 2022) New research is providing strong causal evidence that Gulf War Illness (GWI) is the result of exposure to sarin gas, an organophosphate nerve agent used by Saddam Hussein as a chemical weapon during the Gulf War. The findings, published earlier this month in Environmental Health Perspectives, have important implications for the hundreds of thousands of American service members suffering from a constellation of chronic symptoms without a true understanding of how they became sick. “Quite simply, our findings prove that Gulf War illness was caused by sarin, which was released when we bombed Iraqi chemical weapons storage and production facilities,” said Robert Haley, MD, lead author of the study and epidemiologist at University of Texas Southwestern. “There are still more than 100,000 Gulf War veterans who are not getting help for this illness and our hope is that these findings will accelerate the search for better treatment.” Sarin was first synthesized in the late 1930s by Nazi chemists working for IG Farben (a consortium that included Bayer) in an attempt to create stronger and more powerful insecticides. Sarin is a G-series organophosphate (named after the scientists that created them), characterized by high acute toxicity and […]

(Beyond Pesticides, March 18, 2022) A 2020 lawsuit related to pesticide drift was resolved on March 8, 2022 in San Joaquin (California) Superior Court with the finding that Alpine Helicopter Services, which specializes in pesticide applications for government and tourism entities, had violated pesticide drift laws and endangered public health and safety. The court further found Alpine liable for damage related to its actions, though penalties in the case, brought by California state prosecutors and the California Department of Pesticide Regulation (DPR), have yet to be determined. The case exposes a handful of the many instances of pesticide drift, also known as “chemical trespass,” that occur every year in the U.S. In 2004, Beyond Pesticides covered the issue with Getting the Drift on Chemical Trespass; its monitoring of drift issues is ongoing, as can be seen in its “Pesticide Drift” archives. The long history of nontarget exposure, contamination, and poisoning teaches that drift is a function of pesticide use, but not considered adequately by regulators who allow the marketing of poisons that are known to move through the environment uncontrolled. Cases like the Alpine case highlight a relentless problem associated with the daily use of pesticides. Pesticide drift is any airborne […]

(Beyond Pesticides, February 3, 2022) A study published in the journal Thorax finds lifetime occupational (work-related) exposure to pesticides increases incidents of chronic obstructive pulmonary disease (COPD), including emphysema and chronic bronchitis. Although research often attributes COPD risk to genetics or cigarette smoking, the increasing rate of COPD incidents indicates an external cause of disease development. Although an exact etiology (cause) of the increase in respiratory disease cases remains unknown, the connection between chronic respiratory diseases and exposure to pesticides continues to strengthen. Several circumstances, including smoking patterns, poverty, occupation, and diet, can influence disease prognosis. However, studies show that relative exposure to chemicals like pesticides can occur within each circumstance, making chemical exposure ubiquitous. Additionally, pesticide drift is an omnipresent issue impacting communities surrounding farming operations, and dust may harm humans, plants, and aquatic systems. Therefore, this review highlights the significance of evaluating the association between pesticide exposure and disease development, especially for diseases generally attributed to genetics or vices. Researchers in the study note, “[W]e found that cumulative exposure to pesticides is associated with an increased risk of COPD, with positive exposure-response trends. The unique large sample and the confirmation of our results in sensitivity analyses, in particular in never-smokers, support the validity […]

(Beyond Pesticides, December 16, 2021) A study by Shanghai Jiao Tong University, China, finds Parkinson’s Disease (PD) risk increases with elevated levels of organochlorine (OCP) and organophosphate (OP) pesticides in blood. Among patients with PD, specific organochlorine compounds have greater associations with cognitive impairments, including depression and brain function. Research finds exposure to chemical toxicants, like pesticides, can cause neurotoxic effects or exacerbate preexisting chemical damage to the nervous system. Although the mechanism by which pesticides induce disease development remains unclear, researchers suggest changes in protein enzyme composition and cellular dysfunction from pesticide exposure interrupt normal brain function. Parkinson’s disease is the second most common neurodegenerative disease, with at least one million Americans living with PD and about 50,000 new diagnoses each year. The disease affects 50% more men than women, and individuals with PD have a variety of symptoms, including loss of muscle control and trembling, anxiety and depression, constipation and urinary difficulties, dementia, and sleep disturbances. Over time, symptoms intensify, but there is no current cure for this fatal disease. While only 10 to 15 percent of PD incidences are genetic, PD is quickly becoming the world’s fastest-growing brain disease. Therefore, research like this highlights the need to examine alternate […]

(Beyond Pesticides, December 15, 2021) Monsanto has pleaded guilty to multiple environmental crimes in Hawaiʻi for the second time in less than four years, and the island communities are left asking “when is enough enough?” In the most recent case, Monsanto will plead guilty to 30 environmental crimes in Hawaiʻi, related to pesticide use violations and putting field workers at risk.  In both cases, they admit that they knowingly violated pesticide law and put field workers in harmʻs way.  They will pay a $12 million fine this time, bringing their criminal fines and “community service payments” to a total of $22 million since 2019. At the center of these cases is the fact that the Monsanto field workers had to transport, apply, and suffer exposure to these toxic and banned pesticides as a part of their job. Autumn Ness, director of Beyond Pesticides’ Hawai’i organic land management program,  said: “In small island communities of Hawaiʻi, Monsanto workers are our friends and family. Folks live just downwind and next door to these fields.  We are concerned about their health, and those concerns are glaringly missing from news reports and in the distribution agreements for the community service payments.” There are two […]

(Beyond Pesticides, December 2, 2021) A study published in Cellular Physiology and Biochemistry finds atrazine (ATR) exposure worsens lung disease outcomes in individuals with idiopathic (spontaneous) pulmonary fibrosis (IPF), a group of incurable lung diseases involving damaged/scarred lung tissue. Furthermore, chemotherapeutic products used to treat lymphoma (immune system cell cancer) like bleomycin can induce pulmonary fibrosis complications exacerbated by pesticide exposure. However, pesticide-related pulmonary fibrosis can have implications for neurological health, such as motor function. Scientific literature already finds an association between pesticide exposure and respiratory illnesses such as asthma, lung cancer, and chronic obstructive pulmonary disease (chronic bronchitis). Although IPF impacts over 5 million people a year globally, the disease is difficult to predict, which is concerning as the death rate is 50 to 56 percent within the first few years. Therefore, studies like this highlight the significance of evaluating how pesticide exposure impacts respiratory function, especially when exposure to respiratory toxicants increases vulnerability to existing respiratory-fixated illnesses like Covid-19. Advocate have urged the U.S. Environmental Protection (EPA) to incorporate scientific findings that these—where chemical exposures exacerbate an existing medical condition—into its pesticide registration review program. Researchers note, “[O]ur data represent an addition to the complex information on ATR-induced pulmonary toxicity. In particular, in this […]

  (Beyond Pesticides, November 24, 2021) On Thanksgiving, thank you for being a part of Beyond Pesticides and sharing and contributing to the vision necessary to protect the web and fragility of life. We believe that there is no time like Thanksgiving to think about how we can more effectively join together as families and communities across divisions and different points of view to find a common purpose in protecting the health of the environment and all that inhabit it. Unfortunately, there are a host of pesticides, genetically engineered materials, and others in conventional Thanksgiving foods that not only impact human health, but threaten the environment. With far too many adverse health and ecological effects associated with toxic chemicals, organic practices are viable solutions to mitigate pesticide contamination and subsequent exposure. Read on as we consider the range of challenges we must confront, and the solutions that can bring us all together. The Climate As climate impacts grow, an increase in uses of synthetic pesticides in agriculture is likely — because of waning efficacy (pesticide resistance) of these compounds, and mounting pest pressure (i.e., increasing insect population and metabolism). Production of pesticides contributes to greenhouse gas emissions gas (e.g., nitrous […]

(Beyond Pesticides, November 18, 2021) A study published by King George’s Medical University, India, finds exposure to xenobiotic substances like pesticides during pregnancy increases risks associated with preterm birth, including a rise in cesarean section (C-section) deliveries and a decrease in fetal body weight. Preterm births occur when a fetus is born early or before 37 weeks of complete gestation. Premature births can result in chronic (long-term) illnesses among infants from lack of proper organ development and even death. Birth and reproductive complications are increasingly common among individuals exposed to environmental toxicants, like pesticides. The Center for Disease Control (CDC) reports the preterm birth rate is increasing annually. Therefore, studies like this can help government and health officials safeguard human health by assessing adverse effects following prevalent chemical exposure. The study notes, “To the best of our knowledge, this was a pioneering study, and it may help to increase our knowledge with regard to xenobiotic exposure in biological systems and the need for stringent guidelines for agricultural use of pesticides.” The study examines the association between the transfer of xenobiotics (foreign synthetic substances like pesticides) from mother to fetus. Transferal of these toxic substances can result in biological and chemical changes (i.e., genotoxicity […]

(Beyond Pesticides, September 30, 2021) Individuals working or living in areas with frequent neurotoxic pesticide use experience more amyotrophic lateral sclerosis (ALS) incidences than the general population. The study, published in NeuroToxicology, finds a positive association between sporadic (non-genetic, spontaneous) ALS incidences among individuals exposed to neurotoxic pesticides.  Amyotrophic lateral sclerosis (or Lou Gehrig’s disease) is a neurodegenerative disease that affects the nerves in the brain and spinal cord. As many as 16,000 – 20,000 Americans live with this condition, which weakens muscle/motor function leading to loss of muscle control for walking, talking, eating/swallowing, and breathing. Severe ALS progression is fatal and has no current cure. Although research supports genetic factors play a role in disease etiology (cause), most ALS cases do not result from genetic inheritance. Several research studies demonstrate exposure to environmental or work-related toxicants (i.e., pesticides) predispose humans to the disease. With researchers predicting a global ALS incidence increase of 69% by 2040, identifying ALS’s causal factors are important to future research. Therefore, research like this showcases the importance of assessing aggregate health risks associated with toxic chemical exposure, especially for illnesses, which are not curable. In this study, the researchers note, “[W]e identified pesticides applied to crops in the area of […]

(Beyond Pesticides, July 30, 2021) Bayer (Monsanto), the maker of the deadly herbicide glyphosate/Roundup, after hinting in May that it would end the weed killer’s residential uses in the U.S., made it official yesterday. With its announcement to shareholders, Bayer puts an end to residential uses beginning in 2023 and allocates $4.5 billion to cover “the company’s potential long-term exposure” from lawsuits by those harmed by the chemical. At the same time, the company announced it is seeking a U.S. Supreme Court hearing to reverse significant jury verdicts (from $289 million to $2 billion) for individuals who have suffered health damage they tie to glyphosate exposure. Bayer claims that it will argue that federal pesticide law preempts litigation against products that it has registered with the U.S. Environmental Protection (EPA). Similar arguments have been tried before, most notably in Bates v. Dow Agrosciences (2005), and the Supreme Court has found that federal pesticide law does not protect “manufacturers of poisonous substances.” (See more below.) Despite the extensive scientific review (see Pesticide Gateway) of glyphosate/Roundup and a “probable” cancer causing ranking by the World Health Organization/International Agency for Research on Cancer in 2015, Bayer says, “This move is being made exclusively […]

(Beyond Pesticides, July 15, 2021) A study by ETH Zurich finds multi-crop (mixed culture) farmlands, which include a diverse array of crops, produce higher biomass and seed yields than single-crop (monocultures). Monocultures are most prevalent among arable farmland as commercial industrial farming uses this practice to increase sowing, managing, and harvesting efficiency for higher yields. However, less crop diversity leads to higher, more intensive pesticide use as pests favor the consistent food availability monocultures provide. An increase in toxic chemical use threatens human, animal, and environmental health, as well as food security. Ecological research already finds a positive association between plant diversity and biomass productivity in grasslands and meadows. In addition, a University of California, Santa Barbara study demonstrates that crop diversity in commercial agriculture is just as essential to supporting a stable biological system as plant diversity on non-commercial landscapes (i.e., grasslands/meadows). Therefore, this research highlights the need to develop policies that help farmers and global leaders make more knowledgeable decisions regarding crop diversity to sustain yield without toxic pesticides. The researchers note, “While crop diversification provides a sustainable measure of agricultural intensification, the use of currently available cultivars [(plant varieties for selective breeding)] may compromise larger gains in seed yield. We, therefore, advocate regional […]

(Beyond Pesticides, May 28, 2021) A report by the Office of the Inspector General for the U.S. Environmental Protection Agency (EPA) concludes that scientific analyses by the agency were altered so as to favor top Trump administration officials’ policy choices in the 2018 reapproval of the highly toxic and problematic pesticide, dicamba. The report, “EPA Deviated from its Typical Procedures in Its 2018 Dicamba Pesticide Registration Decision,” was publicly released on May 24. It confirms aspects of what Beyond Pesticides and many others in the science, advocacy, public health, and environmental communities have been saying and reporting since 2016: the Trump administration executed a wholesale assault on scientific integrity in federal decision making. In its research on the matter, the Inspector General’s office (OIG) reviewed EPA’s 2016 and 2018 decisions on dicamba’s registration, documentation that purported to support those decisions, and the concerns forwarded in the ruling by the U.S. Court of Appeals for the Ninth Circuit and by many stakeholders. (See more in figure below.) It also reviewed EPA internal procedures and guidance on pesticide registration, and agency scientific integrity materials; interviewed career scientists and other agency staff; and communicated with EPA’s Scientific Integrity (Science Advisor) program staff. As reported […]

(Beyond Pesticides, April 29, 2021) Glyphosate-based herbicides (GBHs) are incompatible with sustainable agriculture goals, according to a recent scientific literature analysis by scientists at Tufts University, Massachusetts. Glyphosate is the most commonly used pesticide active ingredient worldwide, appearing in many herbicide formulas, including Bayer’s (formerly Monsanto) RoundupTM. The use of this chemical has been increasing since the inception of crops genetically modified to tolerate glyphosate. However, studies demonstrate glyphosate is the main contributor to human, biotic, and ecosystem harms as toxicities from herbicides are now double what it was in 2004.  The National Academy of Sciences identifies four goals of sustainable agriculture—productivity, economics, environment, and social well-being for future generations. However, pesticides like glyphosate are ubiquitous in the environment, putting the health, economy, and food/resources for future generations at risk. Therefore, research like this is vital for understanding how chemical use can undermine sustainable agriculture goals to protect humans, animals, and environmental health. Researchers note, “[W]hether or not GBHs are viewed as essential or unessential to contemporary agriculture, and notwithstanding their role in non-tillage agriculture, this study shows that glyphosate-based herbicides do not reach the bar of agricultural sustainability, with respect to humans and the environment, making the system they are part of unsustainable.” Researchers thoroughly examined […]

(Beyond Pesticides, April 8, 2021) Pesticide use threatens aquatic and terrestrial invertebrates and plants more than ever, despite declining chemical use and implementation of genetically engineered (GE) crops in the U.S., according to a University Koblenz-Landau, Germany study. Since the publication of Rachel Carson’s Silent Spring (1962), many environmental agencies have banned the use of pesticides like organochlorines, organophosphates, and carbamates for their devastating toxic—sometimes lethal—effects, particularly on vertebrates, including humans. However, this ban created a pathway for a new generation of pesticides (e.g., neonicotinoids, pyrethroids) to take hold. Although these pesticides are more target-specific, requiring lower chemical concentrations for effectiveness, they have over double the toxic effects on invertebrates, like pollinators.  Invertebrates and plants are vital for ecosystem function, offering various services, from decomposition to supporting the food web. Furthermore, invertebrates and plants can act as indicator species (bioindicators) that scientists can observe for the presence and impact of environmental changes and stressors. Therefore, reductions in invertebrate and plant life have implications for ecosystem health that can put human well-being at risk. Study lead author Ralf Schulz, PH.D., notes, “[This study] challenge[s] the claims of decreasing environmental impact of chemical pesticides in both conventional and GM [genetically modified or genetically engineered (GE)] crops and […]

(Beyond Pesticides, April 1, 2021) A legacy of toxic pesticide use in agriculture is showing up as residues on organic farms, emphasizing the threat of a history of weak regulatory standards that has left farmland poisoned and the urgent need to transition to organic. A study, published in Environmental Science & Technology, documents the findings of pesticide residues on organic farmland and shows a decrease in residues after transition, with lingering effects for decades.  Some banned pesticides like organochlorines (e.g., DDT and chlordecone) are stable as research demonstrates these chemicals can bind to and linger in the dirt for years to decades. However, other current-use pesticides also pose a soil contamination risk due to drift, runoff, and leaching.  Widespread, increasing pesticide use in genetically engineered crops has implications for contamination of natural resources, including soils. Since pesticide residues can kill off beneficial soil life, impacting soil health and function, agricultural production may decline. Past studies examining pesticide residues rarely investigate residue’s presence in the soil where the chemical has never been used, like organic systems. Therefore, studies like these highlight the need to examine the effect potential pesticide contamination has on soil health, especially in organic where reliance on biological soil […]

(Beyond Pesticides, March 23, 2021) Earlier this month, the Arkansas State Plant Board (ASPB) voted to loosen regulations curtailing use of the highly drift-prone herbicide dicamba. With an 8-7 vote, ASPB eliminated measures advanced in 2016 that protect growers from dicamba drifting off of genetically engineered (GE) soybean fields. Farmer, health, and environmental advocates are encouraging groups and individuals to submit testimony in opposition to the changes should the state’s Governor continue the proposal to a 30-day comment period. Dicamba has been the subject of intense debate and scrutiny over the last several years—most prominently in Southern and Midwestern states where extensive cotton and soybean monocultures are grown. Due to rampant weed resistance to glyphosate herbicides in GE crop fields, Bayer/Monsanto developed new seeds capable of growing into plants that can withstand repeated sprayings of both glyphosate and dicamba. The company released these new seeds in the mid-2010s without waiting for the U.S. Environmental Protection Agency (EPA) to approve a corresponding herbicide formulation Bayer/Monsanto claimed would reduce drift problems. Farmers began using older, unapproved dicamba formulations, but ultimately even after receiving approval, new formulations proved too drift-prone and problematic to be used without incident. In response, ASPB instituted changes that […]

(Beyond Pesticides, March 11, 2021) A Portland State University (PSU) study finds that pesticides from the forestry industry threaten clams, mussels, oysters (bivalves) along the Oregon state coast. Bivalves are excellent indicator species, signaling environmental contamination through their sedimentary, filter-feeding diet. However, continuous pesticide inputs—from various forestry management regimes—into watersheds along Oregon’s coastal zone endanger these species in downstream rivers and estuaries (river mouths). Although research demonstrates many forestry practices (e.g.., road building, planting, clearcutting, thinning) have cumulative effects on the ecosystem, there is a lack of studies addressing the overall impact of multiple chemical mixtures and application on watersheds and subsequent aquatic transport. Like agriculture, conventional forest management across the U.S. depends on the use of toxic pesticides to control pest populations. However, pesticide residues from application drift, runoff, and contamination continuously jeopardize the health and fitness of various non-target species, including humans. Marine ecosystem pollution is difficult to track and measure, and forestry pesticide regulations can invoke variations in water quality requirements through discrepancies in buffer zones and application concentrations. Therefore, studies like this can help guide future forest management practices to reduce the number of chemicals entering aquatic ecosystems. Researchers in the study note, “These findings highlight the need to […]

(Beyond Pesticides, February 18, 2021) New research published in the journal Toxicological Sciences finds extended inhalation of the common herbicide paraquat causes male mice to lose some sense of smell, even at low doses. This study highlights the significance of understanding how specific chemical exposure routes can influence disease development. Olfactory (relating to the sense of smell) impairment is a precursory feature of Parkinson’s disease (PD), and studies connect paraquat poisoning to PD risk. Hence, future pesticide management policies should assess specific disease risks with bodily chemical concentration from low-dose, chronic neurotoxic chemical exposure. The study’s researchers note, “These data support the importance of route of exposure in the determination of safety estimates for neurotoxic pesticides, such as [paraquat]. Accurate estimation of the relationship between exposure and internal dose is critical for risk assessment and public health protection.” Despite evidence demonstrating that olfactory  nerve cells transport toxic airborne particles and solutes to the brain upon inhalation, the possibility of olfactory impairment (damage) from paraquat inhalation lacks adequate assessment. To assess the impact paraquat has on olfactory function, researchers exposed a cohort of adult female and male mice to paraquat aerosols in an inhalation chamber for four hours a day, five days a week, for four weeks. Researchers investigated paraquat concentrations […]