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Estrogen-Mediated Cancers in Humans Have Links to Endocrine Disrupting Pesticides

Tuesday, December 13th, 2022

(Beyond Pesticides, December 13, 2022) Pesticides have a long history associated with hormone (endocrine)-disrupting properties that induce various molecular changes, prompting disease development. Adding to the science, a review published in Environmental Exposure, Biomonitoring and Exposure Assessment highlights how specific estrogen-mimicking pesticides increase the risk of disease, particularly hormone-related cancers among women (i.e., breast, ovarian, endometrial cancer) and men (i.e., testicular, prostate cancer). Like pesticides, endocrine disruptors are xenobiotic (i.e., chemical substances foreign to an organism or ecosystem). Many reports demonstrate that exposure to endocrine-disrupting chemicals can adversely affect human, animal—and thus environmental—health by altering the natural bodily hormones responsible for conventional reproductive, physical, and mental development. Endocrine disruption can lead to several health problems, including hormone-related cancer development (i.e., thyroid, breast, ovarian, prostate, testicular), reproductive dysfunction, and diabetes/obesity that can span generations. Therefore, studies related to pesticides and endocrine disruption help scientists understand the underlying mechanisms that indirectly or directly cause cancer, among other health issues. Pesticides are one of the most potent xeno-estrogenic compounds, as estrogenic strength and environmental half-life exceed those of other xeno-estrogenic compounds. Focusing on organochlorine pesticides (OCs), the study evaluates the chemical effects on the physiological (anatomic) system to increase cancer risk. Using human studies, researchers assessed how estrogen-medicated cancer develops in women and men. […]

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Childhood Pesticide Exposure Associated with Early Onset of Puberty

Thursday, December 8th, 2022

(Beyond Pesticides, December 8, 2022) Children with higher levels of certain pesticide metabolites are more likely to go through early puberty, according to research published recently in Environmental Pollution. The findings by a team of Spanish researchers speak to a need for greater protections for children from toxic pesticide exposure. Children are much more sensitive to pesticide exposure than adults as they take in greater amounts of toxics relative to their body weight and have developing organ systems. Managing homes and yards without chemicals and purchasing organic food whenever possible can significantly reduce childhood pesticide exposure.   Researchers began their investigation with children aged 7-11 participating in the Spanish state’s Environment and Childhood multicenter birth cohort stud, an ongoing project aimed at understanding the effect of environmental exposures on pregnancy, fetal, and childhood development in the country. Out of over 3,000 children enrolled in the project, 1,539 had their urine sampled for the presence of pesticide metabolites. Scientists focused on four insecticides breakdown products—a chlorpyrifos metabolite â€TCPy’, a metabolite of the organochlorine diazinon â€IMPy’, a general organophosphate metabolite â€DETP’, the pyrethroid metabolite â€3-PBA’, and a metabolite of ethylene-bis-dithiocarbamate fungicides â€ETU’. Urinary levels of these pesticide metabolites were then compared against […]

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EPA’s Deficient Pesticide Analysis Contributes to Ecological Decline

Monday, November 21st, 2022

(Beyond Pesticides, November 21, 2022) Once again, the Environmental Protection Agency (EPA) has registered a new pesticide without performing a thorough review of its impacts on biodiversity as well as threatened and endangered species. Inpyrfluxam was registered in 2020 and only after being sued by the Center for Biological Diversity for failure to comply with the Endangered Species Act (ESA) did EPA commit to completing draft effects determinations by Fall 2022. Once again, EPA’s draft biological evaluation is incomplete and inadequate. EPA is accepting comments on its draft biological evaluation at Regulations.gov.  Tell EPA and Congress that Pesticide Registrations Require Complete Science. The Review of Inpyrfluxam is Incomplete and Inadequate.  The agency’s draft effects assessment is flawed and incomplete. We share the details because it shows that EPA is out of step with the science and its regulatory responsibility when it comes a thorough review for ecosystem effects of pesticides.   The agency used fish early life stage (ELS) tests to estimate chronic fish toxicity. This is inappropriate. The fish ELS is a sub-chronic test of sensitive life stages. Although it is often used as a surrogate or predictor of chronic toxicity, it does not adequately address potential adverse effects on reproduction or transfer of the test chemical to eggs/offspring […]

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Synthetic Fertilizers and Pesticides Make Plants Less Attractive to Bumblebees, Research Shows

Tuesday, November 15th, 2022

(Beyond Pesticides, November 15, 2022) Spraying a flowering plant with synthetic fertilizers makes it less attractive to bumblebees, according to research published this month in PNAS Nexus.  “A big issue is thus—agrochemical application can distort floral cues and modify behaviour in pollinators like bees,” said study author Ellard Hunting, PhD, of the University of Bristol, UK. The findings underscore the limited understanding that proponents of chemical agriculture have for the complex processes that food production relies upon and reinforce calls for a broad scale transition to regenerative, organic farming practices. Scientists began with the knowledge that spray applications of various agrichemicals affect the visitation patterns of bumblebees and other pollinators through a range of different processes. Past research finds that notorious bee-killing neonicotinoid insecticides not only kill bees outright, but also result in a range of complex damage, including their ability to impede bees’ olfactory senses and adversely affect their vision and flying ability. Other chemicals like glyphosate weaken bees’ ability to distinguish between colors.   A growing area of research is investigating the ways in which pollinators use static electric fields surrounding flowers to find food sources. A 2013 study found that bumblebees use floral electrical fields to discriminate […]

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Weed Killer Use Destroys Soil Life and Ecosystems, Paper Finds

Friday, November 11th, 2022

(Beyond Pesticides, November 11, 2022) A paper published in Trends in Ecology & Evolution in late October sounds an unnerving alarm about the globally ubiquitous use of herbicides and the ecological destruction being caused. It asserts that widespread environmental contamination with these herbicide compounds is influencing soil, plant, and animal microbiomes in ways that are not only not well understood, but also, can have significant impacts on the functioning of organisms and their ecosystems — with evolutionary implications. Impacts of herbicides on microbiota in soils include, for example, those on nutrient cycling, and altered organism and plant performance, which can affect pollination and animal consumption of plants. This research reinforces what Beyond Pesticides wrote in covering a 2021 study: “The popular herbicide glyphosate negatively affects microbial communities, indirectly influencing plant, animal, and human health. Exposure to sublethal concentrations of glyphosate shifts microbial community composition, destroying beneficial microorganisms while preserving pathogenic organisms.” Herbicides are a category of pesticide used to control weeds in agriculture and commercial forests, on managed landscapes, byways, gardens, and lawns, and directly on surface waters to control aquatic weeds. They are designed to kill “target” plant species considered undesirable in any of those circumstances. Herbicide use has exploded […]

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Breast Cancer Month: Neonicotinoid Insecticides and Breast Cancer Risk (Triple Negative Breast Cancer)

Thursday, October 27th, 2022

(Beyond Pesticides, October 27, 2022) A study published in Environment International adds to the growing body of research evaluating the association between neonicotinoid insecticides (neonics/NIs) and breast cancer. Past studies suggest neonics act as endocrine disruptors, affecting the development and regulation of estrogen hormones that promote breast cancer. However, this study is one of the few to evaluate the toxicological and molecular mechanisms involved in initiating breast cancer events. According to the Centers for Disease Control and Prevention (CDC), breast cancer is a disease that causes breast cells to grow out of control, with the type of breast cancer depending on the cells themselves. Most common forms of breast cancer have receptors on the cell surface that can increase cancer growth when activated by estrogen, progesterone, or too much of the protein called HER2. One in ten women will receive a breast cancer diagnosis, and genetics can only account for five to ten percent of cases. When a cancer cell lacks receptors for these molecules, G protein-coupled estrogen receptors (GPERs) are an essential biological target of estrogen and plays a role in hormone-dependent cancer development. GPERs regulate estrogen through non-genetic cellular pathways, forgoing attachment to standard molecular receptors, leading to triple-negative breast cancer (TNBC). Although past […]

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While Allowing Indoor Pesticide Spray for Covid, EPA Seeks Advice on Improving Indoor Air Quality

Friday, October 21st, 2022

(Beyond Pesticides, October 21, 2022) The U.S. Environmental Protection Agency (EPA) has just made two announcements, related to the quest for improved indoor air quality in buildings, that address mitigation of disease transmission — and that of COVID-19, in particular. Related to enactment of the National COVID-19 Preparedness Plan, EPA issued guidance on the efficacy of antimicrobial products used on surfaces, and registered a new pesticide product the agency says can be used against influenza and corona viruses (some of the latter cause COVID-19 infections). In addition, EPA opened a 60-day public comment period “to solicit information and recommendations from a broad array of individuals and organizations with knowledge and expertise relating to the built environment and health, indoor air quality, epidemiology, disease transmission, social sciences and other disciplines.” Beyond Pesticides cannot help but note the irony of an intention to improve air quality that EPA couples with registration of a new, airborne pesticide for indoor use. EPA expands on its RFI (Request for Information) related to indoor air quality, saying that it is “seeking input from a diverse array of stakeholders . . . about actions, strategies, tools and approaches that support ventilation, filtration and air cleaning improvements, and […]

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Glyphosate Based Herbicides and Bee Health: The American Bumble Bee

Thursday, October 20th, 2022

(Beyond Pesticide, October 20,2022) Exposure to environmentally relevant levels of glyphosate-based herbicides (GBHs) weakens bumblebees’ (Bombus Terrestris) ability to distinguish between colors or fine-color discrimination. According to research published in Science of The Total Environment, a lack of fine-color discrimination skills can threaten bumble bee survivability through impact on colony fitness and individual foraging success. Much research attributes the decline of insect pollinators (e.g., commercial and wild bees and monarch butterflies) over the last several decades to the interaction of multiple environmental stressors, from climate change to pesticide use, disease, habitat destruction, and other factors. In the U.S., an increasing number of pollinators, including the American bumblebee and monarch butterfly, are being added or in consideration for listing under the Endangered Species Act, with specific chemical classes like systemic neonicotinoid insecticides putting 89% or more of U.S. endangered species at risk. Pollinator decline directly affects the environment, society, and the economy. Without pollinators, many plant species, both agricultural and nonagricultural, will decline or cease to exist as U.S. pollinator declines, particularly among native wild bees, limits crop yields. In turn, the economy will take a hit, as much of the economy (65%) depends upon the strength of the agricultural sector. As science shows, pesticides are one of the most significant stressors […]

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Over a Decade and Countless Children Poisoned, EPA Bans Hazardous Flea Collar Products

Wednesday, October 19th, 2022

(Beyond Pesticides, October 19, 2022) Pet flea collars containing the insecticide tetrachlorvinphos (TCVP) are set to be banned by the U.S. Environmental Protection Agency, according to the agency’s long overdue response to a petition from the Natural Resources Defense Council (NRDC). The highly toxic pesticide has not been used on crops since 1987, yet was permitted for decades in flea collars where children could be intimately exposed to the chemical while petting and playing with the family pet. The decade-long process of bringing use of these products to an end exposes the failures of the U.S. pesticide regulatory system, and how EPA’s weak and flawed decisions that infect the marketplace with severe consequences. One may ask: How many veterinarians prescribed these dangerous flea collars to pet owners, assuming that EPA has properly assessed exposure risks to their human owners? Advocates concerned about EPA’s ongoing propensity to defer to the pesticide industry are urging an overhaul of the regulatory process and a reorientation toward toxic pesticide elimination and the adoption of organic in order to address serious health and environmental threats. NRDC originally filed its petition to ban all uses of TCVP in 2009. The petition noted that the agency completely […]

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Study Documents Aggregate Insecticide Load for Pollinators in Real-World Analysis

Friday, October 14th, 2022

(Beyond Pesticides. October 14, 2022) A team of researchers has taken on the challenge of integrating data from multiple and disparate sources in order to devise tools with which scientists can evaluate pollinator pesticide exposures and impacts more effectively at “landscape scale” (and at real-life exposure levels). Accessing data that are useful and relevant at this landscape level has been a significant problem for researchers and conservationists. This “zoomed out” view is critical because pollinators are highly mobile across thousands of meters of foraging area. A functional understanding of the risks pollinators encounter in their territories requires integrated data at this level, as opposed to the large geographic areas across which pesticide use is typically tracked. The team’s paper on their work — Putting pesticides on the map for pollinator research and conservation — was published in Nature.com in mid-September. Pollinators are essential to healthy ecosystems and to a third of human food sources, as well as to plants used for commercial seed production. As the authors note, nearly 90% of flowering plant species benefit from the services of pollinators that help plants set their seeds and produce flowers and fruit (this last term includes foods widely considered to be “vegetables,” […]

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Chemical Alterations in the Body from Glyphosate-Based Herbicide During Perinatal Exposure Induces Chronic Liver Injury

Thursday, October 13th, 2022

(Beyond Pesticides, October 13, 2022) Offspring’s exposure to glyphosate-based herbicides (GBHs) preceding and proceeding birth (perinatal) induces liver damage. A study published in Toxicology and Applied Pharmacology demonstrates the role excess iron in the body from GBH exposure plays in liver toxicity via an increased uptake of calcium and oxidative stress. The liver, the largest solid organ in the human body, is an essential part of the digestive system, responsible for blood detoxification, nutrient metabolization, and immune function regulation. The rates of chronic liver diseases are increasing, representing the second leading cause of mortality among all digestive diseases in the U.S. Because GBHs are ubiquitous in many herbicide products, studies report that these toxic chemical compounds are detectable in infants, children, and pregnant women. Children are particularly vulnerable to the impacts of pesticide exposure as their developing bodies cannot adequately combat exposure effects. Although studies show how chemical exposures affect overall human health, more research is now questioning how these toxic chemicals influence digestive health and the subsequent occurrence of diseases. Therefore, it is essential to understand how harmful chemical exposure impacts health and well-being during critical developmental periods. The study notes, “[T]he possible role played by perinatal exposure to GBH […]

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EPA Asks Federal Court to Allow Reconsideration of Its Decision to Permit Paraquat’s Continued Use

Wednesday, October 12th, 2022

(Beyond Pesticides, October 12, 2022) The U.S. Environmental Protection Agency (EPA) is asking a federal court for permission to go back and reconsider its decision to reapprove use of the highly hazardous herbicide paraquat, according to a filing submitted by the agency late last month. Advocates see the move as encouraging, since meaningful EPA action on this Parkinson’s-linked chemical is long overdue. Last year, advocates condemned the Biden Administration for its reapproval of the weed killer with fewer protections than those proposed by the Trump Administration, marking a deeply concerning sign for pesticide reform campaigners looking to the administration for positive change. EPA’s request is the result of a legal challenge brought by the California Rural Legal Assistance Foundation, Earthjustice, Farmworker Association of Florida, Pesticide Action Network, and the Michael J. Fox Foundation for Parkinson’s Research.  The groups argued that the agency’s decision to reregister paraquat was not legal based on substantial evidence that the chemical poses unreasonable risks to human health and the environment. While EPA made its initial decision to reapprove paraquat in the late days of the Trump Administration, it was under the Biden Administration that the agency reversed a proposed ban on aerial use, permitting broad-scale […]

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Pyrethroid Insecticides Associated with Liver Disease

Friday, October 7th, 2022

(Beyond Pesticides, October 7, 2022) Pyrethroid insecticides are associated with the growing worldwide epidemic of non-alcoholic fatty liver disease (NAFLD), a condition that causes swelling of the liver and can eventually lead to cirrhosis, cancer, or liver failure. According to research published in Environmental Science and Ecotechnology, exposure to pyrethroids like bifenthrin can induce gut microbiota dysbiosis (an imbalance in microorganisms in the intestines). This dysbiosis results in abnormal lipid (fat) metabolism and subsequent accumulation of lipids in liver cells, contributing to NAFLD development. Gut microbiota plays a crucial role in lifelong digestion, immune and central nervous system regulation, as well as other bodily functions. Through the gut biome, pesticide exposure can enhance or exacerbate the adverse effects of additional environmental toxicants on the body. Since the gut microbiome shapes metabolism, it can mediate some toxic effects of environmental chemicals. However, with prolonged exposure to various environmental contaminants, critical chemical-induced changes may occur in the gut microbes, influencing adverse health outcomes. Considering NAFLD is becoming the most prevalent form of liver disease, impacting at least 25 percent of the globe, and a growing body of evidence demonstrates the significance gut microbiota play in overall health, safety analyses that currently do not consider the […]

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Despite EPA Safety Assurances, Alarming Levels of PFAS Found in Commonly Used Pesticides

Thursday, October 6th, 2022

(Beyond Pesticides, October 6, 2022) A new study finds alarmingly high levels of PFAS (Per- and Polyfluoroalkyl Substances) “forever chemicals” in commonly used pesticides, calling into question assurances from the U.S. Environmental Protection Agency (EPA) that contamination is limited to storage containers. For some pesticides, PFAS levels are nearly one billion times higher than the EPA’s recently updated Health Advisory for the PFAS chemical PFOS. “If the intent was to spread PFAS contamination across the globe there would be few more effective methods than lacing pesticides with PFAS,” said Kyla Bennett, PhD, of the nonprofit Public Employees for Environmental Responsibility. “These findings point to an appalling regulatory breakdown by EPA.” A team of researchers based in Texas, including scientists from Texas Tech and the U.S. Department of Agriculture’s (USDA) Cropping Systems Research Laboratory, participated in the study published in the Journal of Hazardous Materials Letters. Ten different formulated pesticide products were tested for 24 different PFAS substances. The pesticide products selected were determined based on unexpected PFAS contamination at USDA’s research facility. During the course of conducting a separate study on plant uptake of PFAS, detectable levels of PFAS were found in plants intended to be used as unexposed controls. […]

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Ingestion of Real-World Pesticide Residues in Grain Threatens Bird Offspring More than Parents

Thursday, September 8th, 2022

(Beyond Pesticides, September 8, 2022) A study published in Environmental Pollution finds parental exposure to real-world, sublethal concentrations of pesticide residues on grains is a major contributor to unfavorable offspring development among foraging birds. Parents’ ingestion of grains with conventional pesticide residues, whether from contaminated or pesticide-treated seeds, results in chronic exposure that adversely affects offspring health, even at low doses. The adverse effects pesticides and other environmental pollutants have on birds are amply documented and researched. Although many studies evaluate acute or chronic health implications associated with pesticide exposure in a single generation, there is a lack of information on multi-generational impacts that can provide vital information on the fundamental survivability or fitness of bird species. Considering this study emphasizes parental exposure to environmental pollutants can have adverse consequences for future generations, it is necessary that future risk assessments for birds address these implications when implementing agricultural pesticide policies. The study notes, “[S]ublethal effects of such compounds [pesticides] on non-target species should be included in the regulation. Moreover, as agroecosystem pollution is not resulting only from pesticides, there is an urgent need to analyze cocktail effects, not only between molecules of pesticides but also between pesticides and other pollutants such as […]

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Antibiotics and Neonicotinoid Insecticides Linked to Gut Microbiome Disruption and Childhood Diabetes

Thursday, August 25th, 2022

(Beyond Pesticides, August 25, 2022) A study published in World Journal of Pediatrics finds an association between antibiotic and neonicotinoid (neonic) exposure and onset of pediatric (childhood) type 1 diabetes (T1D) through effects on the gut microbiome. Individuals with type 1 diabetes are at higher risk of other autoimmune disorders, including thyroid and celiac disease. Ample evidence demonstrates environmental contaminants like pesticides and antibiotics negatively affect human mouth and gut microbes. Through the gut biome, pesticide exposure can enhance or exacerbate the adverse effects of additional environmental toxicants on the body. Moreover, studies find low levels of pesticide exposure during pregnancy or childhood cause adverse health effects from metabolic/immune disorders to mental and physical disabilities. Children are particularly vulnerable to the impacts of pesticide exposure as their developing bodies cannot adequately combat exposure effects. Although studies show how chemical exposures affect overall human health, more research is now questioning how these toxic chemicals influence gut health and subsequent occurrence of diseases. In children, gut microbiome disruption, or gut dysbiosis, has significant associations with type 1 diabetes development, and disruption of gut microbiota plays a role in type 2 diabetes development. Over 11 percent (>37 million) of individuals in the U.S. have diabetes, and cases are growing by millions annually. With increasing rates of type 1 and […]

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Researchers Determine Mechanism of DDT Link to Alzheimer’s, Informing Potential Treatments

Wednesday, August 24th, 2022

(Beyond Pesticides, August 24, 2022) New research is helping the medical community understand the mechanism through which exposure to the banned insecticide DDT increases risk of Alzheimer’s disease. Published in the journal Environmental Health Perspectives, a team of researchers from Florida International University and Rutgers used multiple models to demonstrate the effects of DDT on the production of toxic proteins in the brain. The constant stream of new health risks regarding a chemical banned decades ago underlines the importance of a precautionary approach to pesticide regulation, particularly as red flags are already being raised about the connection between widely used weed killers like glyphosate and neurodegenerative diseases like Alzheimer’s. “The vast majority of research on the disease has been on genetics — and genetics are very important — but the genes that actually cause the disease are very rare,” says study coauthor Jason Richardson, PhD of Florida International University. “Environmental risk factors like exposure to DDT are modifiable. So, if we understand how DDT affects the brain, then perhaps we could target those mechanisms and help the people who have been highly exposed.” Previous research from Dr. Richardson found that DDT exposure increased risk of Alzheimer’s by four times. Scientists […]

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U.S. Exportation of Banned and Highly Restricted Pesticides Continues to Inflict Serious Harm

Friday, August 5th, 2022

(Beyond Pesticides, August 5, 2022) A terrible saga of environmental injustice — and of grieving couples who wanted children but could not have them — is getting new attention via the BBC’s (British Broadcasting Corporation’s) recent coverage of Di-bromochloropropane (DBCP) exposures and impacts on banana plantation workers in multiple Latin American countries. A significant number of those male workers became sterile, and many charge that their exposures to DBCP in the 1970s was responsible. A 1979 ban on uses of DBCP on the U.S. mainland by the U.S. Environmental Protection Agency (EPA) did not immediately stop manufacturers from exporting the toxic insecticide to (primarily) Central American countries, nor did it stop U.S. fruit companies operating there from using it. Beyond Pesticides wrote in 2020 about the damaging and what some call unethical practice of allowing corporate export of domestically banned pesticides — which practice continues in the U.S. This BBC investigative report comes on the heels of a piece in The Lancet, United States and United Nations pesticide policies: Environmental violence against the Yaqui indigenous nation, that catalogues the abuse of pesticide export policies on indigenous peoples. The piece finds: “The Federal Insecticide, Fungicide, and Rodenticide Act (FIFRA) is a U.S. statute that allows “pesticides that […]

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Glyphosate Weed Killer Crosses Blood-Brain Barrier, Linked to Alzheimer’s and Other Neurodegenerative Diseases

Thursday, August 4th, 2022

(Beyond Pesticides, August 4, 2022) An Arizona State University (ASU) study shows that the popular herbicide glyphosate can infiltrate the brain through the blood (blood-brain barrier), increasing neurological disease risk. The blood-brain barrier filters various molecules entering the brain from the circulatory system. However, the permeation of glyphosate molecules elevates the expression of TNFα and the accumulation of soluble beta-amyloid (Aβ) proteins in the brain and has associations with immune, inflammatory, and neurodegenerative diseases like Alzheimer’s disease (AD). More than 6 million people in the U.S. are living with Alzheimer’s, and cases are expected to double by 2050. Although Alzheimer’s research has focused heavily on finding genetic causes of the disease, fewer than half of cases are genetic. Thus, researchers are now evaluating how environmental contaminants may increase disease risk. Over 300 environmental contaminants and their byproducts, including pesticides, are chemicals commonly present in human blood and urine samples and can increase neurotoxicity risk when crossing the brain barrier. Therefore, studies like this highlight the importance of understanding how chemical accumulation in the body can impact long-term health and disease prognosis. The study notes, “Brain glyphosate correlates with increased TNFα levels, suggesting that exposure to this herbicide may trigger neuroinflammation in the brain, which may […]

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Inspector General Finds Secret EPA Meetings with Industry and Use of Untested Science to Lower Cancer Risk for Dangerous Fumigant

Tuesday, July 26th, 2022

(Beyond Pesticides, July 26, 2022) Secret meetings with industry, the elevation of unqualified individuals to decision-making roles, using an untested scientific approach, failing to conduct a simple literature review, and an overall absence of public transparency. This is how the U.S. Environmental Protection Agency’s (EPA) conducted its cancer review for the potent fumigant pesticide 1,3-Dichloropropane (1,3-D; brand name: Telone), according to a report from EPA’s Office of Inspector General (OIG). EPA’s actions allowed a product once considered to pose a 1 in 10,000 risk of cancer to Americans to increase exposure by 9,000% (from 7.7 ÎĽg/m3 to 690 ÎĽg/m3). “These departures from established standards during the cancer assessment for 1,3-D undermine the EPA’s credibility, as well as public confidence in and the transparency of the Agency’s scientific approaches, in its efforts to prevent unreasonable impacts on human health,” the OIG report states. Yet, even with the agency’s failings laid out in clear view, EPA’s lackluster response to OIG’s corrective actions in this case add insult to its injurious actions against public health. OIG initiated a review of EPA’s cancer assessment for 1,3-D after the submission of multiple complaints. 1,3-D is a highly toxic fumigant used on a variety of crops, […]

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Pesticide Exposure Driving Liver Disease through Hormone Disrupting Mechanisms

Thursday, July 21st, 2022

(Beyond Pesticides, July 21, 2022) Research published in Scientific Reports finds an association between the increasing emergence of nonalcoholic fatty liver disease (NAFLD) and exposure to endocrine (hormone) disrupting chemicals, like organochlorine pesticides (OCPs). It is well-known that traces of legacy (past-use) pesticides, like organochlorines, remain in the environment for decades—possibly centuries, post-final application, as OCPs have greater chemical stability and gradual attenuation. However, these chemicals have profound adverse impacts on human health, especially on the endocrine system. Obesity, insulin resistance, type 2 diabetes, and elevated liver enzyme resulting from endocrine disruption contribute to NAFLD and can lead to liver cirrhosis. Although some, but not all, manufacturing and use of specific OCPs have declined in the U.S., OCPs remain a global issue, as much of the developing world still reports usage. Considering the lack of studies on OCP-induced endocrine disruption and NAFLD, research like this highlights the need to understand the underlying mechanisms that contribute to growing endocrine disease incidents.   The study determined that there is an association between OCP exposure and NAFLD using the fatty liver index (FLI), a predictor of lipid (fat) accumulation in the liver. The researcher collected blood serum to measure the concentration of OCPs, specifically evaluating detectable […]

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Common Fungicide Again Linked to Parkinson’s Disease with Molecular Disruption

Thursday, June 30th, 2022

(Beyond Pesticides, June 30, 2022) A study by Zhongnan University and Shandong University in China finds that the broad-spectrum fungicide maneb increases Parkinson’s disease (PD) risk and development through alterations in protein and metabolite pathways, resulting in neurotoxicity. Several studies find exposure to chemical toxicants, like pesticides, have neurotoxic effects or exacerbate preexisting chemical damage to the nervous system. Although the mechanism by which pesticides induce disease development remains unclear, this study suggests neurological damage from oxidative stress, cell dysfunction, and synapses impairment, among others, increases the incidence of PD subsequent to pesticide exposure. Parkinson’s disease is the second most common neurodegenerative disease, with at least one million Americans living with PD and about 50,000 new diagnoses annually. The disease affects 50 percent more men than women, and individuals with PD have a variety of symptoms, including loss of muscle control and trembling, anxiety and depression, constipation and urinary difficulties, dementia, and sleep disturbances. Over time, symptoms intensify, but there is no current cure for this fatal disease. While only 10 to 15 percent of PD cases are genetic, PD is quickly becoming the world’s fastest-growing brain disease. Therefore, research like this highlights the need to examine molecular mechanisms involved in altering chemical […]

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Disappearance of California Bumble Bees Calls for Urgent Protection of Pollinators Nationwide

Thursday, June 23rd, 2022

(Beyond Pesticides, June 23, 2022) In the first California statewide bumble bee census in 40 years, a University of California—Riverside (UCR) study, published in Ecology and Evolution, reveals that once common bumble bee species in California are disappearing from the ecosystem. Wild pollinators like bumble bees provide pollination to billions of dollars worth of crops each year as these insects can flourish in cooler habitats and lower light levels than commercial honey bees. However, pollinators (such as bees, monarch butterflies, and bats) are a bellwether for environmental stress as individuals and as colonies. Both wild and commercial bees and other pollinators encounter multiple stressors, including pesticides, parasites, and poor nutrition, that act together to increase the risk of bee mortality. Therefore, studies like these highlight the need to establish monitoring and conservation frameworks incorporating varying habitats and species to assess fluctuations in biodiversity. The study notes, “Specifically, our study shows that greater monitoring of the diverse bumble bees of California is needed in order to better understand the drivers of biodiversity and decline in this genus, and to more effectively manage bumble bee conservation in the state.”  Researchers compared data on bumble bee populations in California in 1980 and 2020. After collecting bumble […]

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