(Beyond Pesticides, April 18, 2024) University of Michigan researchers have found a statistically significant relationship between heightened risk of amyotrophic lateral sclerosis (ALS) and household exposure to lawn care products and pesticides. The study results were published earlier this month in Amyotrophic Lateral Sclerosis and Frontotemporal Degeneration. The interdisciplinary research team concludes that modifying residential exposure to toxic substances, including pesticides, can play an important role in ALS susceptibility and prognosis. The results build on a substantial body of scientific literature identifying pesticide exposure in various ALS cohort studies. Advocates say that these adverse effects, along with other numerous health and environmental effects, inform their call for the phaseout of toxic pesticide use and the adoption of alternative practices and eco-compatible products. All participants in this study are patients at the University of Michigan Pranger ALS Clinic with Gold Coast ALS diagnosis, which according to a Muscle & Nerve study refers to the identification of two factors: “progressive motor impairment documented by history or repeated clinical assessment” and “the presence of upper and lower motor neuron dysfunction in a least one body region.” All 367 ALS and 255 control patients were tasked with completing a survey in which they self-reported […]

(Beyond Pesticides, April 10, 2024) Researchers in a 2024 Chemosphere study find synergistic relationships in certain chemical mixtures, particularly heptachlor and triallate and trifluralin and lindane at lower concentrations, respectively. “Investigators should consider additional binary data for acute toxicity and potential chronic health impacts on these mixture…which showed synergism at low levels,” the researchers conclude. “According to a Centers for Disease Control (CDC) assessment, more than 50 pesticides are detected in blood or urine samples from the US population,” Researchers point to a cause for concern. The findings come as no surprise to advocates who have urged an assessment of the potential synergistic impacts of pesticide mixtures in the regulation of pesticides. Researchers “used the exposure data from a complex operating site with legacy pesticide pollution to evaluate if Inhalation of pesticide mixtures released from such contaminated sites could pose a risk to human health, The component-based risk assessment approaches that rely on additivity can predict the actual risk of pesticides in a mixture, and The legacy organochlorine pesticides banned many years ago interact with registered and supposedly safe herbicides in a mixture.” The study site is “a pesticide packaging and handling facility” contaminated with the following pesticides (“historical and […]

(Beyond Pesticides, March 27, 2024) A preliminary experiment conducted by Public Employees for Environmental Responsibility (PEER) reveals concerning levels of toxic per- and polyfluoroalkyl substances (PFAS) on the skin of soccer players and coaches after playing on artificial turf fields. The Washington Post reported on March 12 on the PEER test results, which found PFAS levels increased on the skin in three out of four participants following soccer matches on artificial turf. In contrast, no similar increase was observed after games on natural grass fields. The presence of PFAS is alarming due to their association with several serious health issues, including cancer, birth defects, and developmental and immune deficiencies, among others. The U.S. Environmental Protection Agency (EPA) writes that PFAS exposure risks are particularly concerning for young children, who are more susceptible due to their developing bodies and at risk for higher levels of exposure than adults. Known as “forever chemicals” for their persistence in the environment, PFAS continue to accumulate in the human body, posing long-term health risks. Kyla Bennett, PhD, science policy director at PEER and a former scientist and lawyer with EPA, emphasized the need for further research. “Although this study is preliminary, it highlights the potential […]

(Beyond Pesticides, March 20, 2024) A report by CBAN unpacks the ecosystem and wildlife health impacts of genetically engineered (GE) corn in the context of Mexico’s 2023 decision to stop its importation into the country. The phase out of genetically modified (GM) corn imports into Mexico was immediately challenged by the U.S. and Canadian governments as a trade violation under the 2020 U.S.-Mexico-Canada Agreement (USMCA), which replaced the North American Free Trade Agreement (NAFTA) as the primary vehicle for North American trade policy. In August 2023, the U.S. Trade Representative set up a dispute settlement panel under USMCA to stop Mexico from going forward with its ban. There has been no public update from the Office of the U.S. Trade Representative as of this writing. The CBAN report highlights the scientific rationale underpinning Mexico’s decision to “safeguard the integrity of native corn from GM contamination and to protect human health” with this ban. In 2020, Mexico announced a four-year phase-out of the weed killer glyphosate, which along with other petrochemical herbicides is integral to GM corn production. When Mexico’s Minister of the Environment announced the phase-out, he said it is part of an effort to transform the country’s food system […]

(Beyond Pesticides, February 29, 2024)  In the face of federal inaction, an Oregon regulation banning the agricultural uses of the highly toxic chlorpyrifos took effect on January 1, 2024. Chlorpyrifos was voluntarily withdrawn from the market in 2000 for most residential uses by its manufacturer, Dow Chemical, and has been the subject of extensive litigation. At that time, the U.S. Environmental Protection Agency (EPA) allowed most agricultural uses to continue. Oregon joins four other states that have acted to ban chlorpyrifos, including Hawai’i, New York, California, and Maryland.   Central to state action are nervous system and brain effects in children, especially farmworker children. Chlorpyrifos is banned in 39 countries, including the European Union (see here for more Beyond Pesticides coverage). State action has become important since the November 2023 decision by the U.S. Court of Appeals for the 8th Circuit, which overturned the EPA rule revoking all food tolerances for chlorpyrifos, an effective ban on chlorpyrifos use. The final EPA rule, issued in August 2021, came in response to a 9th Circuit Court of Appeals ruling that found the agency’s inaction on chlorpyrifos unlawful. The case was filed by Earthjustice, on behalf of public health, labor, and disability organizations.  The […]

(Beyond Pesticides, February 23, 2024) The latest string of billion-dollar plaintiff judgments against Bayer/Monsanto, the maker of Roundup™ with active ingredient glyphosate, does not yet signal a capitulation by Bayer or a win for public health or the environment in the United States. A jury award of $2.25 billion, the largest to-date, was handed down in Philadelphia in January. As Beyond Pesticides reported previously, Monsanto has a long history of challenging scientific findings on Roundup/glyphosate and evidence of harm to human health, the environment, and crops themselves (see resistant super weeds here and here), as it seeks to avoid liability claims by those suffering from cancer.  Bayer Looking to State Legislatures for Protection from Lawsuits  As result of its failure in quash lawsuits, Bayer has moved its case to state legislatures, where it is seeking the adoption of statutes that preempt liability claims by damaged parties.  As reported by Beyond Pesticides, a rash of state legislation has been introduced in Idaho, Iowa, Missouri, and Florida, which would block plaintiff liability claims when pesticide products, like Roundup, cause harm. The chemical industry pushes the notion that the registration of its pesticide products with the U.S. Environmental Protection Agency (EPA) is a […]

(Beyond Pesticides, February 21, 2024) In addition to its effects including cancer, and reproductive, immune or nervous system disruption, according to international findings, a review published in Toxics finds that the the widely used weed killer 2,4-dichlorophenoxyacetic acid (2,4-D) causes significant changes in liver structure and function. 2,4-D can damage liver cells, tissue, and inflammatory responses through the induction of oxidative stress. The liver, the largest solid organ in the human body, is an essential part of the digestive system responsible for blood detoxification, nutrient metabolization, and immune function regulation. However, rates of chronic liver diseases are increasing, representing the second leading cause of mortality among all digestive diseases in the U.S. In fact, researchers warn of the rise in liver disorders and metabolic syndrome among young people. Therefore, reviews like this highlight the research available to make decisions on safeguarding human health from chemical exposure to mitigate further disease outcomes and complications. 2,4-D is used on turf, lawns, and rights-of-way, as well as in forestry and aquatic systems. 2,4-D products are available as liquid, dust, and granule fields, as well as fruit and vegetable crops, including in genetically engineered crop production. The chemical is widely used in “weed and feed” lawn products. It is […]

(Beyond Pesticides, February 1, 2024) A study published in Science of The Total Environment finds an insecticide ban would be economically beneficial in preventing Parkinson’s disease (PD). Despite differing pesticide exposure scenarios, PD risk lowers without pesticide exposure, especially insecticides that elicit neurotoxicity. In fact, a study published in 2023 notes high exposure to household pesticides, which are primarily insecticides, increases the risk of developing Parkinson’s disease (PD) two-fold. There is a multitude of epidemiologic research on Parkinson’s disease demonstrating several risk factors, including specific genetic mutations and external/environmental triggers (e.g., pesticide use, pollutant exposure, etc.). However, several studies find exposure to chemical toxicants, like pesticides, has neurotoxic effects or exacerbates preexisting chemical damage to the nervous system. Studies suggest neurological damage from oxidative stress, cell dysfunction, and synapse impairment, among others, can increase the incidence of PD following pesticide exposure. Despite the widespread commercialized use of household pesticides among the general population, few epidemiologic studies examine the influence household pesticides, mainly insecticides or disinfectants, have on the risk of PD. Additionally, many studies demonstrate the association between PD onset and occupational (work-related) pesticide exposure patterns. Parkinson’s disease is the second most common neurodegenerative disease, with at least one million Americans […]

(Beyond Pesticides, January 24, 2024) A study published in Environmental Sciences Europe finds that 2,4-D, pyrethroid (PRY), and organophosphate (OP) pesticides increase the risk of cancer through oxidative stress (OS). The study highlights that pesticides that increase cancer risk also raise inflammation biomarkers that indicate damage to organs (e.g., liver) via oxidative stress. Additionally, different cancers show different sensitivities to pesticides; thus, cancer risk changes with exposure concentration and pattern. Despite a plethora of studies linking cancer and pesticide exposure, very few cover the mechanisms involved in cancer development, including OS. Only five to ten percent of cancers are hereditary. However, environmental or lifestyle factors, like chemical exposure, can make an individual more susceptible to cancer development through gene mutation. In fact, a vast amalgamation of research links cancer risk to pesticide exposure, which augments the risk of developing both common and rare cancers. Therefore, studies like this highlight the importance of understanding how pesticide use can increase the risk of latent diseases, which do not readily develop upon initial exposure. Using data from the National Health and Nutrition Examination Survey (NHANES), researchers investigated the link between the risk of several cancers and pesticide exposure. The researchers also thoroughly evaluated […]

(Beyond Pesticides, January 19, 2024) A study published in Environmental Health Perspective is one of the first to indicate a link between exposure to the herbicides 2,4-D and glyphosate and the impairment of behavioral performance (i.e., attention/inhibitory control, memory/learning, language, visuospatial processing, and social perception). These adverse effects associated with the neurotoxic impacts of pesticides on behavior have been previously documented. For example, a study in August 2023 finds oral intake (e.g., eating contaminated foods), inhalation, and dermal exposure to glyphosate lowered cognitive function scores, increased the likelihood of severe depressive symptoms, and impaired auditory (hearing) function. Although previous studies find neurotoxic effects from exposure to these herbicides, very few until now have evaluated how this neurotoxic exposure impacts neurotypical behavior among youth (children and teenagers). The ubiquitous use of glyphosate and 2,4-D use in agriculture—which leaves residues of the toxic chemicals in food and in public areas (e.g., parks and walkways) creates a creates a significant risk for exposure. Glyphosate is already implicated in or proven to lead to the development of numerous health anomalies, including cancer, while 2,4-D also has a range of potential hazards, including cancer. Therefore, studies like this help local and government officials make holistic decisions regarding the use […]

(Beyond Pesticides, January 8, 2024) Despite successful litigation that stopped the unnecessary use of an antibiotic (streptomycin) in citrus production in December 2023, the court’s reasoning fails to grasp the science behind the biggest emerging threat to U.S. and global health—antibiotic resistance. What is most disturbing and challenging is that the U.S. Environmental Protection Agency (EPA), responsible for applying science in the protection of the public’s health, misled the court on the overwhelming worldwide scientific consensus on the contribution of agricultural antibiotic use to the human death and disability rate linked to antibiotic resistance. On this subject, Beyond Pesticides has written extensively about horizontal gene transfer, which explains the movement of antibiotic resistant bacteria throughout the environment, ultimately making their way to people, as medically necessary drugs become ineffective. As we’ve written, “The human pathogenic organisms themselves do not need to be sprayed by the antibiotic because movement of genes in bacteria is not solely “vertical,” that is from parent to progeny—but can be “horizontal”— from one bacterial species to another.” [Regarding the reliance of the court on EPA’s misrepresentation of the science, the court found, ”EPA emphasized that ‘there is no data that antibiotic use in agriculture leads to […]

(Beyond Pesticides, December 19, 2023) Last week, farmworker organizations and Beyond Pesticides, represented by the Center for Food Safety, filed a petition with the U.S. Environmental Protection Agency (EPA) urging that the weed killer glyphosate be removed from the market. The petition cites 200 studies, which represent a fraction of the independent scientific literature on the hazards of glyphosate and formulation ingredients of glyphosate products. This action follows previous litigation in 2022 in which a federal court of appeals struck down EPA’s human health assessment, finding that the agency wrongfully dismissed glyphosate’s cancer risk. The farmworker groups petitioning include Farmworker Association of Florida, Organización en California de Lideres Campesinas, Alianza Nacional de Campesinas, and the Rural Coalition.   Meanwhile, verdicts against glyphosate’s manufacturer, Bayer, continue to pile up with a December jury verdict in Pennsylvania awarding $3.5 million and a November jury in Missouri ordering $1.56 billion to be paid to four plaintiffs. All link their cancer to use of the Roundup. Bayer has lost almost all of the cases filed against it for compensation and punitive damages associated with plaintiffs’ charge that its product (previously manufactured by Monsanto) caused them harm.  The petition summarizes its purpose and justification as […]

(Beyond Pesticides, November 14, 2023) One of the Environmental Protection Agency’s (EPA) strongest tools for avoiding responsibility is delay—a tactic that kept cancellation of the neurotoxic pesticide chlorpyrifos at bay for 21 years—until May 2021, when a three-judge panel of the Ninth Circuit Court of Appeals, responded to a petition filed in 2007 by the Natural Resources Defense Council, Pesticide Action Network, and numerous other groups. The Ninth Circuit ordered the agency to quit lollygagging and acknowledge chlorpyrifos’s threat to human health, something the agency had acknowledged already. The Ninth Circuit instructed EPA to either revoke the “safe” tolerances the agency had set for chlorpyrifos’s residue in various foods or demonstrate that they are actually safe. Finally capitulating, EPA issued a final rule in August 2021 revoking all food tolerances for the neurotoxicant. Tell your governor and mayor to adopt policies that support organic land management.  This looked like progress until February 2022, when a different set of petitioners—pesticide companies, U.S. farmer groups, and other countries’ agricultural interests—filed an action in the Eighth Circuit Court of Appeals. On November 3 of this year, a three-judge panel of the Eighth Circuit reversed EPA’s decision, thereby neutralizing the Ninth Circuit’s opinion. Chlorpyrifos, […]

(Beyond Pesticides, November 10, 2023) In a press conference this week just prior to Veteran’s Day, Department of Veterans Affairs Secretary Denis McDonough affirmed the federal government’s medical support for veterans exposed to toxic chemicals during their service in the military under a law passed last year entitled The Sergeant First Class Heath Robinson Honoring Our Promise to Address Comprehensive Toxics Act of 2022, or PACT Act. The law, passed in August 2022, identifies specific diseases as “presumptive conditions” caused during specified military service. The passage of the law is a tribute to veterans and the public uproar just over one  year ago that demanded that the U.S. Congress recognize and treat diseases caused by toxic chemical exposure during military service. The passage of the PACT Act in 2022 was controversial and first blocked by Republicans in the Senate, but public outrage and high profile support from comedian and activist Jon Stewart ultimately led to final passage. Senate Majority Leader Chuck Schumer (D-NY) said, “For too long, our nation’s veterans have faced an absurd indignity: They enlisted to serve our country, went abroad in good health, and came back home only to get sick from toxic exposure endured while in […]

(Beyond Pesticides, October 12, 2023) A new study published in Environment International finds novel environmental chemicals (i.e., piperidine insecticide, 2,4-dinitrophenol, benzo[a]carbazole, and a benzoate derivative) involved in developing breast cancer through various inflammation pathways. These new potential factors contribute to breast cancer and highlight the importance of employing epidemiological biomonitoring like exposome (total exposure from birth to death) to discover mechanisms involved in disease development that are otherwise overlooked. According to the Centers for Disease Control and Prevention (CDC), breast cancer is a disease that causes breast cells to grow out of control, with the type of breast cancer depending on the cells themselves. Several studies and reports, including U.S. Environmental Protection Agency (EPA) data, identify hundreds of chemicals as influential factors (either promoting or initiating) associated with breast cancer risk. Breast cancer is the most common cancer among women, accounting for 12 percent of all new annual cancer cases worldwide and causing the second most cancer-related deaths in the United States. Past studies suggest genetic inheritance factors influence breast cancer occurrence. However, genetic factors only play a minor role in the incidence of breast cancer, while exposure to external environmental factors (e.g., chemical exposure) appears to play a more notable role. One in […]

(Beyond Pesticides, July 13, 2023) A study published in Environmental Science and Pollution Research finds exposure to p-Dichlorobenzene (p-DCB), a chlorophenol compound with uses as an insecticide, disinfectant, repellent, fumigant, fungicide, and deodorizer, can increase the risk of common endocrine (hormone)-mediated reproductive cancers (i.e., breast, uterine, and ovarian) in women. P-DCB or paradichlorobenzene has carcinogenic (cancer-causing) properties and the chemical has been banned in the European Union (EU) since 2005 for air fresheners and 2008 for mothballs. Being a chlorinated aromatic hydrocarbon (with benzene) compound (chlorobenzene), in addition to its cancer-causing properties, p-DCB can cause acute illnesses like headaches, numbness, sleepiness, nausea and vomiting and chronic effects like nervous system disorders leading to depression, and impact on the brain, birth outcomes, reproductive system, liver, and kidneys. Pesticides have a long history associated with endocrine-disrupting properties that induce various molecular changes, prompting disease development. Adding to the science, a similar review published in Environmental Exposure, Biomonitoring, and Exposure Assessment highlights how specific estrogen-mimicking pesticides increase the risk of disease, particularly hormone-related cancers among women (e.g., breast, ovarian, and endometrial cancer) and men (i.e., testicular, prostate cancer).PDCB, also known as para-dichlorobenzene, contains the carcinogen benzene and is chlorine-based (a chlorinated aromatic hydrocarbon compound), which in December 2019 […]

(Beyond Pesticides, July 11, 2023) A study published in Parkinsonism & Related Disorders finds high exposure to household pesticides increases the risk of developing Parkinson’s disease (PD) two-fold. There is a multitude of epidemiologic research on Parkinson’s disease demonstrating several risk factors, including specific genetic mutations and external/environmental triggers (i.e., pesticide use, pollutant exposure, etc.). However, several studies find exposure to chemical toxicants, like pesticides, has neurotoxic effects or exacerbates preexisting chemical damage to the nervous system. Past studies suggest neurological damage from oxidative stress, cell dysfunction, and synapse impairment, among others, can increase the incidence of PD following pesticide exposure. Despite the widespread commercialized use of household pesticides among the general population, few epidemiologic studies examine the influence household pesticides have on the risk of PD, although many studies demonstrate the association between PD onset via occupational (work-related) pesticide exposure patterns. Parkinson’s disease is the second most common neurodegenerative disease, with at least one million Americans living with PD and about 50,000 new diagnoses annually. Alzheimer’s ranks first. The disease affects 50 percent more men than women, and individuals with PD have a variety of symptoms, including loss of muscle control and trembling, anxiety and depression, constipation and urinary difficulties, dementia, and […]

(Beyond Pesticides, June 27, 2023) Pesticides interfere with biological processes. This is their purpose. Unfortunately, they nearly always have unintended consequences, many of which have been ignored by their manufacturers. A new review article by Irish and Dutch researchers in the ISME Journal adds to the emerging scientific literature examining how pesticides affect the relationship between the human gut and the human brain (the “gut-brain axis”). Often called the “second brain” because it houses nerve cells and produces neurotransmitters, the gut-brain axis may be the most important locus where microbes and pesticides meet. The human gut plays host to a variety of microorganisms, ranging from bacteria and archaea to fungi, viruses and yeasts.[1] In a healthy person these microbes remain in balance and often cooperate both with each other and with human cells. The gut and the brain are deeply integrated through the vagus nerve and the neuroendocrine system. The vagus nerve is a treelike bundle of fibers extending from the lower part of the brain to nearly every body organ, but particularly the heart, lungs and digestive tract. The neuroendocrine system comprises specialized cells inhabiting nearly all the organs of the body that respond to signals from the brain […]

(Beyond Pesticides, May 15, 2023) Say “legacy contaminant” or “forever chemical” and most people today think “PFAS” (perfluoroalkyl substances), but PFAS are just the latest persistent toxic chemicals recognized as presenting an alarmingly difficult cleanup problem. Fortunately, steps are being taken by governments and businesses to eliminate use of PFAS. (Organic farmers concerned about the integrity of their products have been leaders in these efforts.) Although government officials often devote considerable energy and resources to cleaning up contamination, the continued manufacturing of these chemicals and their release into the environment creates a futile situation. The U.S. is a signatory to the 2001 Stockholm Convention, which provides an international framework for moving persistent organic pollutants out of commerce, but the U.S. Senate never ratified it.     Ask your Senators to ratify the Stockholm convention. Tell EPA that persistent toxic pesticides must be considered to pose an “unreasonable risk to the environment under the Federal Insecticide, Fungicide, and Rodenticide Act (FIFRA),” which must result in cancellation of their registrations.  PFAS contamination is just the latest chapter of a very old story. Legacy contamination of our bodies and the environment is partly a result of a slow piecemeal approach to eliminating these toxic chemicals. […]

(Beyond Pesticides, April 12, 2023) Spring represents a period of increased water, soil, and general ecosystem pollution, correlated with increased pesticide use and increased rainfall. Thus, April showers bring May flowers, and often pesticides. We offer this overview to share with friends, family, and your community in an effort to elevate the urgent need to eliminate pesticides and make the shift to organic land management. Pesticides are pervasive in the environment, affecting all ecosystems, including air, water, and soil. Like clean air and water, healthy soils are integral to ecosystem function, interacting between Earth’s four main spheres (i.e., hydrosphere, biosphere, lithosphere, and atmosphere) to support life. Pesticide use results in pervasive contamination of treated and nontarget sites. Even organic farmers and gardeners globally suffer from the widespread movement of pesticides through the air, water, and runoff from land. Attempts to protect property and ecosystems from pesticide use are a difficult, some say impossible, challenge. Efforts to prevent contamination become a large burden, with attempts to curtail pesticide drift with buffer zone areas and eliminate fertilizers or soil supplements with pesticide residues (e.g., manure and compost). Furthermore, the effects of climate change only exacerbate threats to ecosystem health, as studies show a […]

(Beyond Pesticides, April 11, 2023) Natural areas are often considered more pristine than urbanized locations, but a new study published in Nature Communications shows that the soils in natural lands can be just as polluted as those in more densely populated cities. The findings underscore the broad impacts that human activity is having on the health and stability of natural systems around the globe. In order to address widespread contamination, advocates urge government regulators to consider the full cradle to grave life cycle of toxic materials before releasing them into the environment. An international contingent of scientists came together to conduct this research on a global scale, looking at soils on every continent. Soil samples were collected from urban greenspaces and nearby natural areas and paired together. Sampling was conducted in 56 cities in 17 countries, representing six continents. These data were also compared to soil samples taken from remote ecosystems in Antarctica. Scientists tested soils for eight heavy metals, 46 pesticide residues, microplastics, and antibiotic resistance genes. Results reveal a wide distribution of tested contaminants in all samples taken. “Although the level of individual contaminants varied greatly across locations, we detected significant correlations among each type of soil contaminants […]

(Beyond Pesticides, January 30, 2023) Because antibiotics and fungicides are widely used in agriculture (except organic), they contribute significantly to the increasing efficacy problems with antimicrobial (antibiotic and antifungal medicines) use in health care, contributing to a growing crisis. According to Tedros Adhanom Ghebreyesus, PhD, World Health Organization Director-General, “Antimicrobial resistance undermines modern medicine and puts millions of lives at risk.”  Microorganisms—including bacteria, fungi, and viruses—are notoriously quick to evolve resistance to antimicrobial medicines. We know that selection for resistance is directly related to the frequency and intensity of antimicrobial use, so medical practitioners try to avoid using those medicines unless they are necessary. Tell EPA to cancel all uses of a pesticide when resistance is discovered or predicted to occur. Tell Congress to ensure that EPA protects public health from deadly antifungal and antibiotic resistance. Unfortunately, the medical profession lacks complete control over the use of antimicrobials. Many of the same chemicals used in human medicine are also used in agriculture. These may show up in or on treated food, but can also spread antimicrobial resistance through horizontal gene transfer. So, in addition to ingesting antibiotics in our food, the movement of resistant bacteria and fungi in the environment […]

(Beyond Pesticides, January 19, 2023) Research published in Environmental Health Perspectives finds the presence of nine various neonicotinoids (neonics) and six neonic metabolites within human cerebrospinal fluid (CSF). CSF is an essential part of the central nervous system (CNS), especially for CNS development. Specific chemical biomarkers (measurable indicators of biological state), like pesticides, found in CSF are useful for diagnosing and evaluating numerous neurological diseases. The nervous system is an integral part of the human body and includes the brain, spinal cord, a vast network of nerves and neurons, all of which are responsible for many of our bodily functions—from sensed to movement. However, mounting evidence over the past years shows that chronic exposure to sublethal (low) levels of pesticides can cause neurotoxic effects or exacerbate preexisting chemical damage to the nervous system. The impacts of pesticides on the nervous system, including the brain, are hazardous, especially for chronically exposed individuals (e.g., farmworkers) or during critical windows of vulnerability and development (e.g., childhood, pregnancy). Researchers identify the role agricultural chemicals play in CNS impacts causing neurological diseases, like amyotrophic lateral sclerosis (ALS) and Parkinson’s disease, dementia-like diseases such as Alzheimer’s, and other effects on cognitive function. Over 300 environmental contaminants and their byproducts, including pesticides, are chemicals commonly present in human blood […]