Chemical Estrogen-Mimics Impact Asthma, Immune Functioning
Tuesday, April 10th, 2007(Beyond Pesticides, April 10, 2007) Scientists have reported several environmental estrogens can affect the immune system, promoting allergic diseases such as asthma. Researchers have observed this response using pesticides and other environmental contaminants. Focusing on six environmental estrogens (xenoestrogens), researchers were able to reveal how these contaminants affect the immune system. Using doses representative of present human exposures, these estrogen-mimics were tested on human and mouse cells. The observed effect of exposure was both an increase in speed and intensity of immune reactions. Three of the environmental estrogens tested were organochlorine pesticides or metabolites: endosulfan, dieldrin and DDE (DDT metabolite). The other contaminants included nonylphenol, a by-product of plastics manufacturing, and two PCBs. The study reveals that the accelerated and increased level of degranulation of mast cells is the mechanism that causes more severe allergic reactions than would otherwise take place. According to Environmental Health News, mast cells play a vital role in allergic reactions because they are primed by past experience with allergens to release inflammatory agents into the body, which causes an allergic reaction. If the mast cell has been primed to react to a specific allergen, it will degranulate, releasing molecules such as histamine. The more intense […]










