(Beyond Pesticides, July 19, 2022) Banned pesticides still persistent in the environment pose an increased risk of hearing impairment for U.S. adults, according to research published this month in Scientific Reports. Although regular use of DDT and hexachlorobenzene (HCB) no longer occurs in the United States, exposure to these persistent chemicals can still occur through a range of sources, including air, water, sediment, soil and food. As new science continues to find harmful health effects of older pesticides, advocates say new laws are needed to ensure long term hazards don’t arise from the more than 1,200 active ingredients currently registered by the US Environmental Protection Agency (EPA) with little to no independent scientific oversight. Hearing loss affects nearly 40 million (~15%) American adults over age 18. While it is clear that common causes like aging and noise exposure can result in hearing loss, there has been increasing attention to the role environmental contaminants may be playing in hearing disorders. To explore any potential connection, researchers analyzed data from the long-running U.S. National Health and Nutrition Examination Survey (NHANES). Blood serum levels of the organochlorine insecticides HCB, p, p’-DDE (a breakdown product of DDT), trans-nonachlor, and dieldrin were compared against audiometry […]

(Beyond Pesticides, July 14, 2022) A study published in Toxicology and Applied Pharmacology finds prepubescent exposure to endocrine-disrupting chemicals (EDCs), including pesticides, impairs male reproduction through the interruption of testicular homeostasis and development of reproductive Leydig cells. Endocrine disruptors are xenobiotic (i.e., chemical substances like toxic pesticides foreign to an organism or ecosystem). Many reports demonstrate that exposure to endocrine-disrupting chemicals can adversely affect human, animal—and thus environmental—health by altering the natural hormones in the body responsible for conventional reproductive, physical, and mental development. Scientists and health officials already associate pesticide exposure with a decrease in male fertility, including reduced sperm count, quality, and abnormal sperm development. The presence of pesticides in the body has implications for human health, especially during vulnerable life stages, such as childhood, puberty, pregnancy, and old age. Therefore, it is essential to understand how exposure to toxic chemicals in the environment affects future reproductive success and health. The researchers note, “Recent studies revealed that exposures to EDCs during so-called critical windows of susceptibility (prenatal, prepubertal, pubertal, and aging periods) could disrupt healthy patterns of testes development and homeostasis, which can be demonstrated as an impaired testicular function later in life. However, much more work is needed to understand better the cellular […]

(Beyond Pesticides, July 7, 2022) A review article published in the International Journal on Environmental Sciences highlights how pervasive pesticide exposure and climate change threaten global species biodiversity. Now more than ever, people are changing their sentiment toward sustainability, with two-thirds of consumers stating the importance of limiting climate change impacts and 88 percent supporting greater pollution reduction. The relationship between climate change and biodiversity—a “distinct but related issue”— is often overlooked in the regulation of the pesticide industry. Climate change and biodiversity loss are interdependent, and an adverse impact on one can bolster adverse effects on the other. Biodiversity is intricate and affects all environmental ecosystems—from oceans and freshwater to forests and soils; it encompasses all life forms on earth. Without biodiversity, food production, energy production, clean water, fertile soil, sustained air quality, and climate will suffer. The globe is currently going through the Holocene Extinction, Earth’s 6th mass extinction, with one million species of plants and animals at risk. With the increasing rate of biodiversity loss, advocates say it is essential for government agencies to hold the pesticide industry accountable for the direct (i.e., excessive agrochemical use) and indirect (i.e., water pollution from run-off) impacts on ecosystems. The review notes, “The enormous use […]

(Beyond Pesticides, June 30, 2022) A study by Zhongnan University and Shandong University in China finds that the broad-spectrum fungicide maneb increases Parkinson’s disease (PD) risk and development through alterations in protein and metabolite pathways, resulting in neurotoxicity. Several studies find exposure to chemical toxicants, like pesticides, have neurotoxic effects or exacerbate preexisting chemical damage to the nervous system. Although the mechanism by which pesticides induce disease development remains unclear, this study suggests neurological damage from oxidative stress, cell dysfunction, and synapses impairment, among others, increases the incidence of PD subsequent to pesticide exposure. Parkinson’s disease is the second most common neurodegenerative disease, with at least one million Americans living with PD and about 50,000 new diagnoses annually. The disease affects 50 percent more men than women, and individuals with PD have a variety of symptoms, including loss of muscle control and trembling, anxiety and depression, constipation and urinary difficulties, dementia, and sleep disturbances. Over time, symptoms intensify, but there is no current cure for this fatal disease. While only 10 to 15 percent of PD cases are genetic, PD is quickly becoming the world’s fastest-growing brain disease. Therefore, research like this highlights the need to examine molecular mechanisms involved in altering chemical […]

(Beyond Pesticides, June 16, 2022) Farmed salmon serves as an inferior food source, accumulating more toxic chemicals in fatty tissue with fewer healthy nutrient properties based on a study from the University of Bergen, Norway and Alternative Medicine Review. However, the issue of toxic chemical contamination in fish dates back decades with investigations demonstrating high levels of persistent organic pollutants (POPs), including polybrominated diphenyl ethers (PBDEs) flame retardants restricted or banned in the U.S. and U.K., polychlorinated biphenyl (PCBs), dioxin (a by-product of pesticide manufacturing), and ethoxyquin (a pesticide preservative in fish feed). The aquaculture industry (e.g., farmed seafood/fish) repeatedly faces sustainability issues, failing to adhere to environmental regulations and threatening marine health. Extensive use of pesticides in local marine ecosystems has induced coastal habitat loss and increased genetic and health risks to wild marine populations. Moreover, insecticides used to kill salmon parasites (e.g., fish lice) has led to widespread disease persistence and pest resistance. Marine species biodiversity is rapidly declining due to overfishing, global warming, pathogens, and pollution. Thus, further biodiversity loss can change aquatic and terrestrial ecosystem functions and reduce ecosystem services. Food analysis results find the consumption of farmed salmon fillets contributes to higher rates of metabolic disorders, including diabetes and obesity. These farmed salmon also contain levels […]

(Beyond Pesticides, June 9, 2022) A report from the Organic Center finds that people in U.S. BIPOC (Black, Indigenous, and People of Color) communities endure a significant disproportionate risk of exposure to pesticides and subsequent harms. The report also contains a lesson plan that informs young activists on how to improve the food system. Many communities of color and low-socioeconomic backgrounds experience an unequal number of hazards, including nearby toxic waste plants, garbage dumps, and other sources of environmental pollution and odors that lower the quality of life. Therefore, these populations experience greater exposure to harmful chemicals and suffer from health outcomes that affect their ability to learn and work. Doctoral candidate at Northwestern University and author of the report and lesson plan, Jayson Maurice Porter, notes, “Urban planning and city policy considers certain people in certain communities more or less disposable and puts them in harm’s way, giving them an uneven burden of experiencing and dealing with things like pollutants.”  The father of environmental justice, Robert Bullard, Ph.D., defines environmental racism as any policy or practice that unequally affects or disadvantages individuals, groups, or communities based on their race. Dr. Bullard stated that, until the 1980s, environmentalism and pollution were separate. During the Jim […]

(Beyond Pesticides, May 31, 2022) Fifty years after the banning of DDT, the notorious insecticide is still harming iconic birds of prey along the California coastline. According to research published in Environmental Science and Technology, California condors and marine mammals along California’s coast are contaminated with several dozen different halogenated organic compounds (hazardous, often-chlorinated chemicals) related to DDT, chlordane, and other now-banned legacy chemicals. The findings highlight the incredible importance of addressing these original “forever chemicals,” and making certain that we do not continue to repeat the mistakes of the past with new and different, yet equally dangerous, chemistries. Between 1947 and 1971, the Montrose Chemical Corporation of California, the largest historical producer of DDT, released over 1,700 tons of DDT into the LA sewer system, which eventually made its way into the Pacific Ocean. During this time, several other companies discharged PCBs, leading to further chemical contamination of land and sediment. As recent as April 2021, scientists discovered 25,000 barrels likely containing DDT near Catalina Island along the southern California coast. These releases have resulted in serious environmental and health problems throughout the coastal food chain. Yet, as the present study shows, scientists are only beginning to understand the […]

(Beyond Pesticides, May 26, 2022) A study published in The International Journal of Biochemistry & Cell Biology finds environmental exposure to neurotoxic pesticides increases Parkinson’s Disease (PD) risk through gastrointestinal (GI) disruption. Research finds exposure to chemical toxicants, like pesticides, can cause neurotoxic effects or exacerbate preexisting chemical damage to the nervous system. Although the mechanism by which pesticides induce disease development remains unclear, this study suggests environmental pesticide exposure disrupts GI cells responsible for supporting the autonomic nervous system. Enteric glial cells (EGCs) are GI cells that play a critical role in the functional changes that accompany GI dysfunction, as this dysfunction is one of the earliest symptoms indicating the onset of PD. Parkinson’s disease is the second most common neurodegenerative disease, with at least one million Americans living with PD and about 50,000 new diagnoses each year. The disease affects 50% more men than women, and individuals with PD have a variety of symptoms, including loss of muscle control and trembling, anxiety and depression, constipation and urinary difficulties, dementia, and sleep disturbances. Identifying early biomarkers of PD, such as pesticide-mediated toxicity on GI cells, is crucially important as symptoms intensify overtime, with no current cure for this fatal disease. While only […]

(Beyond Pesticides, May 17, 2022) With public awareness of an ongoing ‘insect apocalypse’ growing, one of the first anecdotes people often note is how many fewer bugs are found splatted onto their car windshield than in the past. In a recent survey, conservation groups in Britain are finding evidence of insect declines in exactly that place, providing scientific backing for these concerning suspicions. Between 2004 and 2021, 58.5% fewer flying insects were squashed onto car license plates. “The results from the Bugs Matter study should shock and concern us all,” says Paul Hadaway, conservation director at Kent Wildlife Trust, which conducted the study alongside UK organization Buglife. “We are seeing declines in insects which reflect the enormous threats and loss of wildlife more broadly across the Country. These declines are happening at an alarming rate and without concerted action to address them we face a stark future. Insects and pollinators are fundamental to the health of our environment and rural economies.” The survey was conducted primarily through citizen science, utilizing the “Bugs Matter” mobile app, and a sampling grid, referred to as a ‘splatometer’ that is affixed to a car’s license plate. Data was retrieved from trips taken by citizen […]

(Beyond Pesticides, May 5, 2022) A report published in Biological Conservation finds environmental pollutants, including pesticides, pharmaceuticals, plastics, and particulate matter, adversely affect tropical terrestrial wildlife. Specifically, these contaminants can interact with one another, altering the chemical landscape of the ecosystem, and causing changes in the endocrine and microbiome systems of mammals. Since the publication of Rachel Carson’s Silent Spring (1962), global attention to the danger of pesticides has increased, with environmental agencies banning the use of legacy pesticides like organochlorines for their devastating toxic—sometimes lethal—effects. However, these chemicals can remain in the environment for decades and interact with various current-use pesticides, including organophosphates, neonicotinoids, and pyrethroids. Although many studies demonstrate that environmental pollution plays a significant role in premature deaths among humans, there is a lack of research on how environmental pollution directly affects tropical species mortality. Considering human and wildlife habitats tend to overlap, and chemical pollutants can drift from chemically treated areas, wildlife populations are more likely to experience similar health effects. With the number of chemicals in the ecosystem growing, studies like these highlight the need for pesticide policies that protect human health in addition to the integrity of the chemical landscapes accommodating wildlife. The researchers note, “Using […]

(Beyond Pesticides, April 27, 2022) Pesticides can accumulate in aquatic fly larvae, be retained through metamorphosis, and represent a source of chronic pesticide exposure to birds and bats, according to research published in Environmental Science and Technology earlier this month. As population declines among these critical wildlife continue to mount, findings like these highlight the complex ways in which human activities are further stressing natural systems. Pesticide reviews conducted by the U.S. Environmental Protection Agency (EPA) are limited to an outdated set of studies conducted by the pesticide industry, and generally reject and dismiss emerging science from independent literature. This myopic focus on industry studies has brought widespread contamination to the natural world that necessitates wholescale changes at EPA through Congressional action. With widespread acknowledgement that older pesticide chemistries, such as organochlorines like DDT and aldrin, bioconcentrate in living organisms, researchers aimed their study at present use fungicides and herbicides that have not yet undergone similar scrutiny. This includes seven fungicides—azoxystrobin, boscalid, cyflufenamid, fluopyram, tebuconazole, pyrimethanil, and trifloxystrobin—and two herbicides—napropamide and propyzamide. The study notes that formulated end use products, rather than technical grade active ingredients, were used in order to best mimic real world exposure conditions. Larvae of the […]

(Beyond Pesticides, April 20, 2022) A University of Michigan study is the first to highlight that maternal pesticide exposure during pregnancy adversely affects sleeping patterns for offspring later in life, specifically for females. Prenatal development is one of the most vulnerable periods of exposure as the fetus is most susceptible to the harmful effects of chemical contaminants. Many studies indicate that prenatal and early-life exposure to environmental toxicants increases susceptibility to diseases, from learning and developmental disabilities to cancer. However, the toxicity of pesticide exposure ad its full impact on the nonagricultural population in the U.S., especially women. Given research links to sleep-related disorders and neurological and cognitive development, studies like this can help government and health officials identify how pesticides’ impact on the brain elevates health concerns. The authors note, “Overall, these results are of public health importance considering the continued widespread agricultural and possibly residential use of pyrethroids and chlorpyrifos [in Mexico]…Thus, our results underline the importance of additional research studies that include both larger samples and assessment of unregulated pesticides, as well as studies that consider the underlying mechanisms explaining sex differences.” Levels of inadequate sleep patterns are rising among children and adolescents. Reports find variability in sleep duration results in higher rates of depression, anxiety, and […]

(Beyond Pesticides, April 5, 2022) A meta-analysis by the Federal University of Technology – Paraná finds the herbicide 2,4-D causes indiscriminate harm, increasing the mortality rate among exposed animals. The severity of chemical exposure relies on species sensitivity, exposure rate, and lifecycle stage. However, commercial formulations of 2,4-D, commonly used in the environment, prompt a higher species mortality rate than technical (pure) 2,4-D alone. Like many other common herbicides such as glyphosate, 2,4-D has global uses that allow the chemical to accumulate in the environment, including soils, waterways, and tissues of non-target species. Therefore, meta-analyses like this help local and government officials make holistic decisions regarding environmental contaminants that incorporate conclusions from various studies. Using the Web of Science and Scopus databases, researchers compiled various studies (or meta-analyses) on the lethality of 2,4-D in different animal species (e.g., vertebrates, invertebrates). Researchers evaluated each study regarding the mortality rate of control and experimental groups, animal sensitivity to chemical exposure during a specific life stage, chemical formulation (e.g., commercial or technical), and exposure routes causing mortality. The analysis demonstrates that vertebrates experience higher mortality rates from 2,4-D exposure, with fish and birds presenting the highest mortality rate. Regarding life stages, larval and adult […]

(Beyond Pesticides, March 23, 2022) A study published in Nature Reviews Earth & Environment warns that thawing of permafrost (a ground that remains completely frozen for two or more years) in the Arctic region can prompt the reemergence of greenhouse gases (e.g., methane and carbon dioxide), microbes, and chemicals (e.g., banned pesticides like DDT). Past research finds gases, microbes, and chemicals drift near the poles, becoming entrapped in ice under the accumulating snowfall. As the global climate continues to rise and the climate crisis worsens, studies like this show significant effects, as ice encapsulating these toxic chemicals is melting. Upon melting, some chemicals can volatilize back into the atmosphere, releasing toxicants into the air and aquatic systems, with the ensuing consequences. Microbes frozen for thousands to millions of years can also emerge from thawing permafrost, with unknown implications on human, animal, and ecosystem health. The melting permafrost is already beginning to impact infrastructure, creating sinkholes that damage roads, trees, and utility poles. Moreover, mixtures of chemicals, microbes, and greenhouse gases (GHGs) in permafrost are difficult to assess. Therefore, studies like this highlight the need to evaluate the health and ecological effects of melting arctic permafrost (and glaciers) from anthropogenic (human)-induced climate change. […]

(Beyond Pesticides, February 28, 2022) When bacteria and fungi become resistant to pesticides, it is a signal that the toxic chemical approach to controlling pathogens does not work. But resistance also poses a direct threat to human health when the pesticide (or a related chemical) is used in human medicine. Tell EPA to cancel all uses of a pesticide when resistance is discovered or predicted to occur. Tell Congress to ensure that EPA protects public health from deadly antifungal and antibiotic resistance. The threat of resistance in bacterial human pathogens has long been widely recognized. Although research sponsored by the Environmental Protection Agency (EPA) recognizes the spread of resistance to antibiotics important in human medicine through horizontal gene transfer in the environment, EPA inaction both on antibiotic and antifungal resistance has become a growing crisis. EPA does recognize the existence of resistance to fungicides. It uses codes produced by the Fungicide Resistance Action Committee in decisions regarding fungicide registration. Although EPA says resistance “may be considered in the risk-benefit decision-making process,” there is no evidence that the agency actually considers the failure of EPA-registered pesticides to control the target organisms in registering pesticides. That failure has a serious impact on […]

(Beyond Pesticides, February 18, 2022) A new analysis conducted by Safer States, and reported on by Environmental Health News (EHN), concludes that in 2022, at least 32 states will consider 210 potential laws to ban or restrict one category of so-called “legacy” chemicals — the PFAS (per- and polyfluoroalkyl substances) family of compounds. “Legacy” or “forever” chemicals are those whose historical use, including many decades ago in some instances, has led to their toxic persistence in the environment and in organisms. In recent years, scientists, health and environment advocates, and policy makers have begun to recognize these as very serious contaminants, and to call attention to their ubiquity and impacts. Beyond Pesticides has identified multiple instances of such “legacies” (including those related to the production of pesticides and particularly, the infamous DDT), and will here discuss both PFAS, and concerns about such legacy chemicals as they may impact food producers. The term “legacy” often connotes the ongoing influence or impact — generally salutary — of an individual’s activity, or a set of principles or activity inherited from one’s forebears. It is an apt description, minus the “salutary” part, for legacy chemicals — toxic “gifts that keep on giving” via persistent contamination […]

(Beyond Pesticides, February 11, 2022) A team of researchers has proffered a potential, biotechnical, way forward in the quest to reduce the scourge of malaria, which affects many people across the world. Their work uses the relatively new “Crispr” technique to address, and reverse, the growing problem of mosquito resistance to the pesticides that currently dominate control strategies for the insects that spread the disease. This innovation nevertheless raises concern about both the introduction of new, genetically altered organisms into the environment without sufficient information on the implications, and continued, intensive pesticide use. Beyond Pesticides recognizes, as do the researchers, that malaria-borne mosquitoes pose a serious public health problem; however, it advocates for alternatives to chemical approaches to managing the spread of the disease, and asserts that successful management strategies will contend with the underlying conditions that exacerbate that spread. In 2020, Executive Director Jay Feldman said, “We should focus on the deplorable living conditions, and inequitable distribution of wealth and resources worldwide that give rise to squalor, inhumane living conditions, and the poor state of development that, together, breed insect-borne diseases like malaria.”     Malaria, which is spread by female Anopheles mosquitoes infected with a Plasmodium parasite, causes illness in more than 200 million people annually, and is lethal to more than 400,000, […]

(Beyond Pesticides, February 4, 2022) In January, the U.S. Department of Agriculture (USDA) issued its 30th Pesticide Data Program (PDP) Annual Summary report (which evaluates each year the presence of pesticide residues on produce) and misleads the public on the safety of food and agricultural practices. This 2020 report concludes that more than 99% of the produce samples tested showed residues below established U.S. Environmental Protection Agency (EPA) benchmark levels. At first blush, this sounds very reassuring, but Beyond Pesticides maintains that there is (always) more to the “safety” story, not least of which are serious deficiencies in EPA’s establishment of those “tolerances.” Those flaws include a lack of risk assessment for vulnerable sub-populations, such as farmworkers, people with compromised health, children, and perhaps, cultural/ethnic and regional sub-groups of the general population, and a failure to fully assess serious health outcomes such as disruption of the endocrine system (which contributes to numerous serious diseases). For everyone, Beyond Pesticides recommends choosing organic produce whenever possible — the vast majority of which does not contain synthetic pesticide residues. The PDP report asserts that “the data . . . illustrate that residues found in agricultural products sampled are at levels that do not pose […]

(Beyond Pesticides, January 12, 2022) Well water in agricultural regions of Sri Lanka is contaminated with highly hazardous insecticides and associated with a decline in kidney function, according to research published in npj Clean Water this month. This finding is the latest piece in an ongoing ‘puzzle’ regarding the epidemic of chronic kidney disease of unknown origins in Sri Lanka and other developing countries in agricultural regions. Although the exact etiology of the disease has not been confirmed, a number of scientific studies have pointed the finger at industrial agriculture, increasingly finding evidence of chronic pesticide exposure in affected populations.   To better understand the connection between agrichemical exposure and kidney health, researchers enrolled 293 individuals from Wilgamuwa, Sri Lanka into a prospective study. Baseline data was retrieved on occupational and environmental exposure factors, focusing in on the water source individuals used at their homes. Samples of each participant’s household wells were taken and analyzed for the presence of pesticides. Of the wells sampled, 68% were found to contain pesticides. Further, every well where pesticides were detected had at least one pesticide recorded above global drinking water guidelines. The chemicals found were also some of the most toxic pesticides to […]

(Beyond Pesticides, December 16, 2021) A study by Shanghai Jiao Tong University, China, finds Parkinson’s Disease (PD) risk increases with elevated levels of organochlorine (OCP) and organophosphate (OP) pesticides in blood. Among patients with PD, specific organochlorine compounds have greater associations with cognitive impairments, including depression and brain function. Research finds exposure to chemical toxicants, like pesticides, can cause neurotoxic effects or exacerbate preexisting chemical damage to the nervous system. Although the mechanism by which pesticides induce disease development remains unclear, researchers suggest changes in protein enzyme composition and cellular dysfunction from pesticide exposure interrupt normal brain function. Parkinson’s disease is the second most common neurodegenerative disease, with at least one million Americans living with PD and about 50,000 new diagnoses each year. The disease affects 50% more men than women, and individuals with PD have a variety of symptoms, including loss of muscle control and trembling, anxiety and depression, constipation and urinary difficulties, dementia, and sleep disturbances. Over time, symptoms intensify, but there is no current cure for this fatal disease. While only 10 to 15 percent of PD incidences are genetic, PD is quickly becoming the world’s fastest-growing brain disease. Therefore, research like this highlights the need to examine alternate […]

(Beyond Pesticides, November 18, 2021) A study published by King George’s Medical University, India, finds exposure to xenobiotic substances like pesticides during pregnancy increases risks associated with preterm birth, including a rise in cesarean section (C-section) deliveries and a decrease in fetal body weight. Preterm births occur when a fetus is born early or before 37 weeks of complete gestation. Premature births can result in chronic (long-term) illnesses among infants from lack of proper organ development and even death. Birth and reproductive complications are increasingly common among individuals exposed to environmental toxicants, like pesticides. The Center for Disease Control (CDC) reports the preterm birth rate is increasing annually. Therefore, studies like this can help government and health officials safeguard human health by assessing adverse effects following prevalent chemical exposure. The study notes, “To the best of our knowledge, this was a pioneering study, and it may help to increase our knowledge with regard to xenobiotic exposure in biological systems and the need for stringent guidelines for agricultural use of pesticides.” The study examines the association between the transfer of xenobiotics (foreign synthetic substances like pesticides) from mother to fetus. Transferal of these toxic substances can result in biological and chemical changes (i.e., genotoxicity […]

(Beyond Pesticides, November 12, 2021) Omnivorous readers may have encountered an article, in the November 15 issue of The New Yorker magazine, titled — at best misleadingly, and certainly sensationally — “The Great Organic-Food Fraud.” The subhead comports with the tone of the headline: “There’s no way to confirm that a crop was grown organically. Randy Constant exploited our trust in the labels — and made a fortune.” The piece, by Ian Parker, tells a complex tale of the machinations of dishonest and greedy people who saw, in the commerce in organic grains, an opportunity to misrepresent nonorganic crops as organic and make a boatload of money in doing so. What the article fails to do is render any comprehensive picture of how National Organic Program certification and inspection work, and the underlying principles, values, and standards in federal law (the Organic Foods Production Act), nor does it review either the benefits of organic agriculture broadly or the massive harmful impacts of conventional, chemical-intensive agriculture in the U.S. Beyond Pesticides provides ballast, in this Daily News Blog article, to the failings of the New Yorker article and the damage it might do to the organic movement. It is worth noting […]

(Beyond Pesticide, November 4, 2021) A scientific literature analysis by the Federal University of Goias, Brazil, finds occupational (work-related) exposure to agricultural pesticides increases the risk for 45 different types of cancer. This analysis assesses studies from the last decade—2011 to 2020—to identify cancer risk associated with occupational exposure by country, pesticide type, and methods used to diagnose disease. Many pesticides are “known or probable” carcinogens (cancer-causing agents), and widespread uses only amplify chemical hazards, adversely affecting human health. However, research on cancer and pesticides lacks comprehensive information regarding human health effects associated with long-term chemical use. This study highlights the significant role that long-term research plays in identifying potential health concerns surrounding registered pesticides. The use of these xenobiotics (foreign chemical compounds) substances in agriculture are increasing. Thus, it is important those working with and around these toxicants have protection. The analysis notes, “Overall, then, the results of the present study emphasize the need to evaluate overuse of pesticides and the concomitant increase in the number of cancer cases. Future research should thus include active intervention in the correct use of pesticides by farmworkers and encourage adequate training and the use of PPEs [personal protective equipment], as well as routine periodic medical […]