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Study Finds that Childhood Exposure to Insecticides Associated with Brain Tumors

Wednesday, January 20th, 2010

(Beyond Pesticides, January, 21, 2009) A new study concludes that exposures during pregnancy and childhood to insecticides that target the nervous system, such as organophosphates (OPs) and carbamates, are associated with childhood brain tumors. The researchers hypothesize that this susceptibility might be increased in children with genetic variations that affect the metabolism of these chemicals. The study, “Childhood Brain Tumors, Residential Insecticide Exposure, and Pesticide Metabolism Genes,” examines whether childhood brain tumors (CBT) are associated with the functional genetic variations. The study provides evidence that exposure to insecticides, paired with specific metabolism gene variants, may increase the risk of CBT. DNA was extracted from archival screening samples for 201 cases â‰¤ 10 years of age and born in California or Washington State between 1978 and 1990. Insecticide exposures during pregnancy and childhood were classified based on interviews with participants’ mothers. The children’s mothers reported whether they or anyone else had chemically treated the child’s home for insects including termites, fleas, ants, cockroaches, silverfish, or “other” pests. The results are consistent with the possibility that children with a reduced ability to metabolize organophosphate and carbamate insecticides might be at increased risk of CBT when sufficiently exposed. The researchers observed multiplicative interactions […]

Posted in Children/Schools, Chlorpyrifos, Diazinon, Disease/Health Effects | No Comments »

Study Finds that Mosquito Repellent DEET Affects Nervous System

Wednesday, August 12th, 2009

(Beyond Pesticides, August 12, 2009) A new study examining the effects of the mosquito repellent DEET on insects, mice and human proteins reports that the chemical interferes with a prominent central nervous system enzyme. This effect is magnified when exposure to DEET is combined with exposure to certain other pesticides. Entitled, “Evidence for inhibition of cholinesterases in insect and mammalian nervous systems by the insect repellent deet,” and published in BioMed Central (BMC) Biology, the study utilized toxicological, biochemical and electrophysiological techniques to show that DEET is not simply a behavior-modifying chemical, but that it also inhibits cholinesterase activity in both insect and mammalian neuronal preparations. The researchers examined DEET’s effects on mosquitoes, cockroach nerves, mouse muscles, and enzymes purified from fruit flies and humans. Applications of DEET slowed or halted the actions of the enzyme acetylcholinesterase. This enzyme is crucial for regulating nerve impulses in both insects and mammals, and once its functions are disrupted, neuromuscular paralysis, leading to death by asphyxiation result. In humans, symptoms include headache, exhaustion and mental confusion together with blurred vision, salivation, chest tightness, and muscle twitching and abdominal cramps. The study also investigated the consequences of DEET interactions with carbamate insecticides on the […]

Posted in Alternatives/Organics, Chemicals, DEET, Disease/Health Effects, Gulf War Syndrome, Nervous System Effects | 5 Comments »

Pesticides in Combination Shown to Increase Endangered Salmon Threat

Thursday, March 5th, 2009

(Beyond Pesticides, March 5, 2009) A new study published in the March 2009 issue of Environmental Health Perspectives finds that pesticide combinations cause more harm to endangered salmon than ndividual pesticide exposure. This means that single-pesticide risk assessments required by the Environmental Protection Agency (EPA) inadequately assess hazards. Mixtures of organophosphate and carbamate pesticides are commonly detected in freshwater habitats that support threatened and endangered species of Pacific salmon. According to the researchers from the National Oceanic and Atmospheric Administration (NOAA) Fisheries and Washington State University, these pesticides inhibit the activity of acetylcholinesterase (AChE) and thus have potential to interfere with behaviors that may be essential for salmon survival. The researchers measured brain AChE inhibition in juvenile coho salmon exposed to sublethal concentrations of the organophosphates diazinon, malathion, and chlorpyrifos, as well as the carbamates carbaryl and carbofuran. The pesticides were tested individually and in combination. They plotted AChE levels on a curve to determine whether the toxicologic responses to binary mixtures were additive, antagonistic (lesser than additive) effect, or synergistic (greater than additive). The authors observed addition and synergism, with a greater degree of synergism at higher exposure concentrations. Several combinations of organophosphates were lethal at concentrations that were […]

Posted in Chemicals, Chlorpyrifos, Diazinon, Malathion, Water, Wildlife/Endangered Sp. | No Comments »

New Study Links Fungicides to Parkinson’s Disease

Monday, December 1st, 2008

(Beyond Pesticides, December 1, 2008) A new study by researchers at the University of California Los Angeles finds chronic exposure to commonly used dithiocarbamate fungicides, such as ziram, contribute to the development of Parkinson’s disease. According to the study, Ziram Causes Dopaminergic Cell Damage by Inhibiting E1 Ligase of the Proteasome, published in the Journal of Biological Chemistry, researchers screened several pesticides for their ability to interfere with the ubiquitin-proteasome system (UPS). Impaired UPS activity is reported in Parkinson’s disease patients’ brains. The researchers then focused on dithiocarbamate fungicides because they were found to be one of the most potent UPS inhibitors and are commonly used. The researchers discovered the mechanisms by which the UPS is impaired, showing that ziram and structurally related dithiocarbamates inhibit E1 ligase (a protein activating enzyme). Ziram is also found to increase alpha-synuclein (a protein expressed in the central nervous system) levels and selectively damages dopaminergic neurons in vitro. The study also cites unpublished data from a population-based study in central California that is determining pesticide exposure using state application registry, finding that individuals living within 500 meters of where ziram is applied are at three times the increased risk of developing Parkinson’s compared to […]

Posted in Children/Schools, Parkinson's, Ziram | No Comments »

Gulf War Research Panel Finds 1 in 4 Veterans Suffers from Illness Caused by Toxic Exposure

Tuesday, November 18th, 2008

(Beyond Pesticides, November 18, 2008) At least one in four of the 697,000 U.S. veterans of the 1991 Gulf War suffer from Gulf War illness, a condition caused by exposure to toxic chemicals, including pesticides and a drug administered to protect troops against nerve gas, and no effective treatments have yet been found, a federal panel of scientific experts and veterans concludes in a landmark report released November 17, 2008. The Congressionally-mandated Research Advisory Committee on Gulf War Veterans’ Illnesses presented the report to Secretary of Veterans Affairs James Peake at Veterans Administration (VA) headquarters in Washington, DC. Scientific staff support to the Committee is provided by the Boston University School of Public Health (BUSPH). “The extensive body of scientific research now available consistently indicates that Gulf War illness is real, that it is the result of neurotoxic exposures during Gulf War deployment, and that few veterans have recovered or substantially improved with time,” the report says. The 450-page report brings together for the first time the full range of scientific research and government investigations on Gulf War illness and officially resolves many questions about the condition. The report found that Gulf War illness fundamentally differs from stress-related syndromes described […]

Posted in Bendiocarb, Chemicals, Gulf War Syndrome | No Comments »

Chemical Exposure Linked to Gulf War Veterans’ Illness

Thursday, March 13th, 2008

(Beyond Pesticides, March 13, 2008) Exposure to certain chemicals, including pesticides and nerve agents, explains the high rates of illness in Persian Gulf War Veterans, according to a new study published in the Proceedings of the National Academy of Sciences. Veterans from the 1990-91 conflict have a higher rate of chronic, multi-symptom health problems than either non-deployed personnel or those deployed elsewhere. Symptoms routinely reported by these veterans include fatigue, muscle or joint pain, memory problems, trouble sleeping, rash and breathing problems. Due to the findings, the study author, Beatrice Golomb, M.D., Ph.D., associate professor of medicine at the University of California, San Diego School of Medicine, warns of the potential risk to civilians exposed to pesticides.“Health issues among Gulf War veterans have been a concern for nearly two decades. Now, enough studies have been conducted, and results shared, to be able to say with considerable confidence that there is a link between chemical exposure and chronic, multi-symptom health problems,” said Dr. Golomb. “Furthermore, the same chemicals affecting Gulf War veterans may be involved in similar cases of unexplained, multi-symptom health problems in the general population.”The study synthesized evidence regarding a class of chemicals known as acetylcholinesterase inhibitors (AchEs), including […]

Posted in Acephate, Aldicarb, Bensulide, Carbaryl, Chemicals, Chlorpyrifos, Diazinon, Dichlorvos, Disease/Health Effects, Fenoxycarb, Gulf War Syndrome, Malathion, Parathion, Propetamphos, Propoxur, Trichlorfon | No Comments »

National Healthy Schools Day: Support Pesticide-Free Schools

Monday, April 30th, 2007

(Beyond Pesticides, April 30, 2007) Today, school officials, teachers, parents and community activists around the country are celebrating National Healthy Schools Day. The Healthy Schools Network, which organizes the event, and event supporters, including Beyond Pesticides, believe that every child in every community should have an environmentally safe and healthy school that is clean and in good repair. Schools in poor condition on the outside often have indoor environmental problems that affect children’s health and learning. Children face unique hazards from pesticide and other toxic chemical exposure. They take in more pesticides relative to their body weight than adults in the food they eat and air they breathe. Their developing organ systems often make them more sensitive to toxic exposure. The U.S. EPA, National Academy of Sciences, and American Public Health Association, among others, have voiced concerns about the danger that pesticides pose to children. The body of evidence in scientific literature shows that pesticide exposure can adversely affect a child’s neurological, respiratory, immune, and endocrine system, even at low levels. Several pesticides, such as pyrethrins and pyrethroids, organophosphates and carbamates, are also known to cause or exacerbate asthma symptoms. Buildings in disrepair typically face higher rates of pest infestation […]

Posted in Children/Schools, Events | 1 Comment »

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