(Beyond Pesticides, April 28, 2026) In Chemical Research in Toxicology, researchers from the Universitat Rovira i Virgili in Catalonia, Spain highlight the threats to human and environmental health with “combined exposures to multiple chemical toxicants, including industrial chemicals, heavy metals, pesticides, endocrine-disrupting chemicals (EDCs), and per- and polyfluoroalkyl substances (PFAS).” As these compounds are encountered in mixtures in real-world settings, the resulting interaction can have additive or synergistic effects that risk assessments fail to adequately capture. As the authors point out: “This leads to a systematic underestimation of health risks, particularly for vulnerable populations. Despite robust evidence on mixture toxicity, major regulatory frameworks such as the U.S. Toxic Substances Control Act (TSCA) and the EU’s [European Union] REACH program continue to assess chemicals in isolation.” Importance and Background Environmental toxicants are ubiquitous throughout nature and within all organisms. In humans, these compounds can accumulate, referred to as ‘Body Burden’, which encompasses numerous chemicals such as pesticide mixtures. “Critically, organisms are rarely exposed to a single chemical in isolation,” the researchers note. “Rather, they continuously encounter complex mixtures of contaminants whose combined effects may differ substantially from those predicted by examining each substance individually.” As the authors explain, regulatory agencies underestimate […]

(Beyond Pesticides, April 17, 2026) A comparative analysis published in The Lancet Planetary Health highlights the pervasiveness of pesticide pollution in organic and non-organic farms in Latin America (Costa Rica) and Africa (Uganda). While pesticides were detected in nearly all participating farmers, there is a significant relationship between lower biomarker concentrations (often correlating with less contamination) in urine samples of organic farmers relative to non-organic farmers. The researchers also identified that older farmers held higher herbicide and insecticide concentrations. This research builds on the preponderance of scientific evidence and lived experiences of agricultural communities across the globe, including the U.S., which documents nontarget contamination of food systems through air, water, and soil. In this context, Beyond Pesticides continues to advocate for a transition to organic land management practices. Methodology and Results “We collected urine samples from 601 conventional and organic smallholder farmers in Zarcero County, Costa Rica, and Wakiso District, Uganda, on two occasions during the primary spraying season,” the authors write in introducing their methodology. The researchers tested urine samples of small-scale farmers in Costa Rica and Uganda for a mix of pesticides that include a fungicide, herbicide and insecticides—mancozeb (ETU), 2,4-D, glyphosate, pyrethroid metabolites (3-PBA, DCCA), diazinon (IMPy), […]

(Beyond Pesticides, April 9, 2026) “The routine use of common pesticides in agriculture is no longer an ethically viable option for sustainable food production,” according to a new review in Reproduction & Fertility by livestock researcher Whitney Payne, Ph.D. candidate, and Kelsey R. Pool, PhD, of the School of Agriculture and Environment at The University of Western Australia. They base their position on the endocrine-disrupting qualities of many pesticides. The authors describe endocrine-disrupting compounds (EDCs) as “an inescapable feature of modern life” and note that the “farming systems sit at the intersection of animal health, environmental integrity, and food production.” The review stresses the risks that EDCs pose to livestock, which are seriously understudied.   EDCs are introduced to cattle, sheep, chickens, goats, and other mammals via pesticides, plastics, and hormone treatments. Since humans consume livestock, the effects of EDCs on animals are not confined to animals themselves. Animal production systems illustrate how EDCs “can enter diverse food chains and ecosystems from a single source,” the authors write, being introduced by humans for one purpose and returning to affect livestock and humans indirectly through their long-term effects and breakdown products. While regulatory systems typically consider direct and indirect exposure pathways in […]

(Beyond Pesticides, April 1, 2026) Researchers at the University of Washington and members of the Washington State Liquor and Cannabis Board published a commentary piece in Clinical Therapeutics highlighting the growing inadequacy of state-level regulatory safeguards for pesticide contamination of cannabis products. The Environmental Protection Agency (EPA) is unable to assess pesticide residues, nor is it permitted to set tolerance limits under the Federal Insecticide, Fungicide, and Rodenticide Act (FIFRA), because, according to the Controlled Substances Act (CSA), cannabis is a Schedule 1 narcotic, meaning there is “no accepted medical use.” As a result, EPA cannot conduct a full assessment of pesticide exposure associated with inhalation, ingestion, and dermal (skin) adsorption. There is an ongoing rescheduling process that was proposed in 2024 and followed up with an executive order in late 2025 to transition cannabis toward Schedule III status, suggesting that there would be an opening for EPA to promulgate rulemaking to support state-level regulations if it were to move forward. An analysis of active legislation in state legislatures for the 2026 session highlights the concerns—at least 14 states (including Connecticut, California, Georgia, Hawai’i, Illinois, Iowa, Kansas, Kentucky, Maine, New Hampshire, Oklahoma, Virginia, West Virginia, and Wisconsin) had bills to […]

(Beyond Pesticides, March 24, 2026) Published in Environmental Pollution, study results in the floriculture region of Ecuador find detections of neonicotinoid insecticides (NNI) and the herbicide atrazine in drinking and irrigation water. The biomonitoring data reported in an earlier journal article in the same region found a total of 23 compounds used as herbicides, insecticides, and fungicides, their associated metabolites (breakdown products), which include organophosphates, pyrethroids, and neonicotinoids. (See Daily News here.) Researchers from the University of Iowa, University of California, San Diego State University, and Universidad de San Francisco in Quito, Ecuador, determined that 1 in 5 households (20.5%) have detectable levels of one or more neonicotinoids in drinking water samples surrounding floricultural agricultural operations. This builds on previous research underscoring the nontarget pesticidal effects in communities near agricultural operations where the chemicals drift through the air and move into soil and water. Methodology and Results The authors report that, “This study focused on household tap water in proximity to floricultural plantations and in the ESPINA [Secondary Exposures to Pesticides among Children and Adolescents] participants’ homes with a range of NNI and total pesticides in urinary metabolite samples of the children.” They continue: “Participant households in the water study were […]

(Beyond Pesticides, March 13, 2026) In a press release on March 10, 2026, Public Employees for Environmental Responsibility (PEER) cites independent test data on the herbicide indaziflam with detections of per- and poly-fluoroalkyl substances (PFAS), the “forever chemicals” known for significant toxicity at low level exposure and high persistence. The product, Rejuvra™, is produced by Envu (a former division of Bayer) and “is being sprayed and considered for use across millions of acres of Bureau of Land Management (BLM) and US Forest Service land.” Scientific literature connects indaziflam and PFAS with adverse effects to human, soil, and biodiversity health, raising serious concerns about their wide use in agriculture and general land management of lawns, parks, playing fields, ornamentals, fence lines, rights-of-way, rangeland, open space, and Christmas trees. Background As a pre-emergent weed killer used to kill annual grasses and unwanted broadleaf plants, the fluoroalkyltriazine herbicide is broadly labeled for use in residential areas, commercial ornamental and sod production, forestry, and mostly orchard crops. While indaziflam is considered a “selective” herbicide, it actually kills and prevents germination of a wide range of broad-leaved plants and grasses and comes close to being a soil sterilant.  Since the chemical is subject to drift […]

(Beyond Pesticides, March 12, 2026) The science connecting pesticide exposure to neurotoxicity continues to mount. A study in Discover Toxicology highlights neurotoxic pollutants as significant environmental threats, showcasing the adverse impacts on vertebrates’ neurological health from pesticides, including organophosphates, carbamates, and organochlorines. “These substances disrupt normal neurophysiological functions by impairing neurotransmission, generating oxidative stress, provoking neuroinflammation, and initiating neuronal cell death,” the authors say. They continue, “Such disturbances are linked to cognitive deficits, motor impairments, and abnormal neural development.” Neurological conditions can manifest as headaches, muscle weakness, tremors, paralysis, coordination challenges, vision loss, hallucinations, vertigo, seizures, memory loss, slurred speech, trouble breathing with minimal exertion, and more. The range of adverse effects from low-dose, long-term exposure and low-dose (or subchronic) exposure during developmental phases of life raises serious questions about the adequacy of the regulatory review of pesticides, which focuses on acute high and lethal dose exposure. One study on the neurotoxicity of pesticides, published in Chemosphere, concludes, “New regulatory and preventive measures to mitigate the neurotoxic effects of pesticides are needed.” (See also Daily News.) Even at low concentration, chronic exposure to pesticides and other environmental contaminants “poses serious ecological and health concerns” that occur as these chemicals “bioaccumulate […]

(Beyond Pesticides, March 5, 2026) In a deep analysis of public records, U.S. Right to Know (USRTK), a nonprofit newsroom and public health research group, discloses significant financial ties between Bayer-Monsanto, lobbying firms, and the second Trump Administration, raising concerns about basic safeguards to curb corporate influence over federal policymakers. The USRTK tracker and report, “Tracing Bayer’s ties to power in Trump’s Washington,” (see more) finds that there have been significant lobbying investments by the multinational pesticide corporation just in the past year, including:  “At least $9.19 million on federal lobbying in [2025]”;   “16 key administration officials with ties to Bayer’s lobbying or legal network. Bayer and its lobbyists have access to people in power at the White House, U.S. Department of Agriculture, the Environmental Protection Agency and even those in high level positions closest to Trump”;  “45 people registered to lobby for Bayer under the Lobbying Disclosure Act, and at least 13 outside lobby firms – seven of which are now among the highest-paid firms in D.C”; and,  “More than 30 senior officials at lobby firms retained by Bayer have direct ties to Trump, having worked in one or both of his administrations or political campaigns.”  The report points out that the four main trade and […]

(Beyond Pesticides, February 26, 2026) Published in PLOS ONE, research in Brazil “analyzed the impact of occupational/household chronic exposure to pesticides on the clinicopathological profile of breast cancer in rural women from Paraná southwest, a predominantly rural landscape with large pesticide uses,” finding that “pesticide exposure favors the occurrence of more aggressive breast cancer.” The study highlights the disproportionate risks of pesticides to farmworkers, focusing on women, as it compares exposed and unexposed populations and breast cancer tumor/disease characteristics. One of the study authors, Carolina Panis, PhD, discussed her earlier research at the Beyond Pesticides’ 42nd National Forum Series, The Pesticide Threat to Environmental Health: Advancing Holistic Solutions Aligned with Nature. In her previous work, Pesticide exposure and increased breast cancer risk in women population studies, Dr. Panis documents a number of pesticides that “can increase the risk of BC [breast cancer] development through various mutagenic [genetic mutations] and nonmutagenic mechanisms and can act directly as carcinogens or indirectly as biochemical modifiers and hormonal deregulators. The underlying mechanisms include endocrine disruption; genotoxicity; epigenetic changes [changes to gene function without changing DNA]; enhanced cell migration, invasion, and…” more. Dr. Panis and other researchers at the Forum support community-level understanding of the […]

(Beyond Pesticides, February 12, 2026) Editor’s Note. This is a piece about improving risk assessments and a proposal that could offer a more realistic characterization of the harm associated with the complexities of pesticide exposure. Beyond Pesticides notes that risk assessment methodology, unless it is considered in the context of a rigorous alternatives assessment, begins with the mostly false assumption that petrochemical pesticides are needed (or are essential) to achieve cost-effective pest management, agricultural productivity and profitability, and quality of life, when, in fact, this is not the case. Therefore, improved risk calculations—as the article being reviewed here proposes—while important to characterizing the harm and the unknown adverse effects associated with pesticide use, still impose some level of harm deemed by the government to be acceptable. Even worse, the adverse effects of exposure cannot be fully characterized because of uncertainties or a lack of data on harmful endpoints, as is the case currently with endocrine-disrupting pesticides not fully evaluated by the U.S. Environmental Protection Agency (EPA), California’s Department of Pesticide Regulation (DPR), or other regulatory bodies. These pesticides are known to induce cancer, reproductive harm, infertility, biodiversity decline, and other life-threatening, often multigenerational, effects. The authors do recognize the serious […]

(Beyond Pesticides, February 4, 2026) Using data from the Agricultural Health Study (AHS) database launched in 1993 by the National Cancer Institute and the National Institute of Environmental Health Sciences, research study results “show greater diabetes risk“ from exposure to organochlorine, organophosphate, and carbamate insecticides, phenoxy and other herbicides, and the fumigant carbon tetrachloride/disulfide exposure. The study, published in Environment International, evaluated nearly 4,000 diabetes cases drawn from AHS follow-up surveys between 1999 and 2021. Results Researchers found evidence of an association between 18 pesticide active ingredients and diabetes. These included two phenoxy herbicides, 2,4,5-T and 2,4,5-TP, and seven organochlorine insecticides (DDT, aldrin, dieldrin, chlordane, heptachlor, toxaphene, and lindane). While all these organochlorine pesticides are banned for use in the U.S. (with the exception of pharmaceutical uses of lindane), legacy residues of the chemicals and/or their metabolites continue show up in the environment, food, and the human body, and 2,4,5-T and its TCDD dioxin contaminant has multigenerational effects. There was exposure risks among other pesticides were identified as well, including: 3 organophosphate insecticides (diazinon, malathion, and phorate); 2 carbamate insecticides (carbofuran and carbaryl); 3 other herbicides (butylate, metribuzin, and chlorimuron ethyl); and the fumigant carbon tetrachloride/disulfide. The median age of […]

(Beyond Pesticides, January 27, 2026) A three-part study published in Molecular Neurodegeneration draws a connection between Parkinson’s disease (PD) and the organophosphate chlorpyrifos. “Since chlorpyrifos (CPF) exposure has been implicated as a risk factor for PD, we investigated its association to incident PD and if this association is biologically plausible using human, rodent, and zebrafish (ZF) studies,” the researchers state. Together, the three experiments “strongly implicate exposure to CPF as a risk factor for developing PD,” as the authors find that exposure, even at very low concentrations, causes selective toxicity to dopaminergic neurons that are critical for functions of movement, cognition, emotion, and more. The results reveal that in humans, long-term residential exposure is associated with more than a 2.5-fold increased risk of developing PD, while exposure in mice causes “motor impairment, dopaminergic neuron loss, microglial activation, and an increase in pathological α-synuclein (α-syn) [proteins primarily found in the brain].” The researchers continue, “Using ZF, we found that CPF-induced dopaminergic neuron loss was at least partially due to autophagy dysfunction and synuclein accumulation, as knocking down LC3 [a protein chain] recapitulated the dopaminergic neuron loss.” These three studies highlight the association of CPF with increased risks for developing PD, as […]

(Beyond Pesticides, January 26, 2026) As a mounting number of scientific studies link pesticides to adverse health and environmental effects not evaluated under the U.S. Environmental Protection Agency’s (EPA) pesticide registration program, members of Congress are planning to introduce legislation that elevates the organic solution. To this end, Beyond Pesticides and allies are calling on U.S. Representatives and Senators to become a cosponsor of the Opportunities in Organic Act, which is expected to be reintroduced in early 2026 by U.S. Senator Peter Welch and U.S. Representative Jimmy Panetta. In its Pesticide-Induced Diseases Database, Beyond Pesticides critiques studies associating pesticides with serious adverse effects ignored by the regulatory process, including multigenerational effects, chronic low-dose exposure and aging, impacts on fertility dysfunction, synergistic effects associated with mixtures, and endocrine disrupting effects, among others. At the same time, there is a growing body of evidence demonstrating the environmental, health, climate, and economic benefits of organic agriculture.  With the weakening of pesticide regulation, the organic alternative has become especially important, according to health and environmental advocates. However, the organic growth needed to reverse the looming health and environmental crises will not be achieved without a societal investment in organic transition, they say. Although consumption of organic food continues to grow in the U.S., domestic production lags behind. The Opportunities in […]

(Beyond Pesticides, January 22, 2026) Published in Environmental Research, a review of experimental studies by George Mason University researchers regarding reproductive toxicity of neonicotinoid pesticides (neonics) in rodents finds that all studies “demonstrated negative impacts on male reproductive endpoints in association with neonic exposure, including reduced sperm count, reduced sperm motility, and altered sperm morphology.” These studies highlight how neonics, designed to target insect nervous systems, can affect mammalian systems, representing risks to human health. Criteria for inclusion in the review was restricted to endocrine and/or reproductive outcomes in male rats and mice, leading the authors to analyze 21 studies published between 2005 and 2025. “This narrative review employed a systematic approach and determined that neonics exhibit reproductive toxicity in male rats and mice, particularly impairing testicular function and sperm quality at high exposure levels,” the researchers report. They continue, “Despite species-specific differences, the conserved nature [core mechanism] of reproductive processes across mammals supports the relevance of these findings to human health.” Study Background Neonicotinoids are a class of insecticides that share a common mode of action that affects the central nervous system of insects, resulting in paralysis and death. There is a wide body of science on the effects […]

(Beyond Pesticides, January 13, 2026) An important study in Nature Microbiology challenges the entrenched assumption in the chemical industry and among regulators that synthetic chemicals can be targeted for specific uses and have limited effects beyond those uses. The categorization of chemicals into pharmaceuticals, pesticides, and industrial chemicals masks their commonalities and combined potential for deep harm to biological systems. In particular, the effects of the onslaught of xenobiotics (not naturally produced) on human gut microbiota are of increasing concern. The study, by an international team including researchers at the National Institute of Environmental Health Sciences, Cambridge University, and Heinrich Heine University in Germany, tested a set of xenobiotics, including pharmaceutical, pesticide, and industrial compounds, against 22 human gut bacteria. Using both in silico (computers) and in vitro (laboratory experiments), they found 168 chemicals that exerted inhibitory effects on the gut bacteria. Most of these interactions had not been previously reported. Of the xenobiotic categories, fungicides and industrial chemicals were the most influential. The researchers note that the “pervasive use” of synthetic chemicals “and environmental persistence have led to pollution levels exceeding the planetary boundary for stable and resilient Earth systems” [emphasis added] and that “safety assessments for these chemicals […]

(Beyond Pesticides, January 12, 2026) With a pattern of chemical industry deception of independent scientific review, and the recent retraction of an influential Monsanto ghostwritten article (April 2000) on the weed killer glyphosate (Roundup™), Beyond Pesticides and its network are calling for oversight hearings in Congress. At issue is the reliance of the U.S. Environmental Protection Agency (EPA) on industry data and agency collusion with chemical manufacturers on its decisions. Beyond Pesticides is questioning the underlying reliability of the data, in addition to limitations of the regulatory review process in meeting its statutory duty to protect health and the environment. In addition to the deception, key underlying deficiencies are EPA’s failure to evaluate endocrine disrupting pesticides and synergistic effects of chemical mixtures. Given these deficiencies and the cost effectiveness of organic land management and crop production Beyond Pesticides is asking Congress to hold oversight hearings to determine how EPA can eliminate the use of toxic pesticides that are no longer needed to grow food or manage landscapes cost-effectively.  Critically, the Federal Insecticide, Fungicide, and Rodenticide Act (FIFRA) and EPA’s pesticide program allow toxic chemicals to be dispersed, resulting in widespread negative impacts, without regard for the availability of cost-effective and profitable alternatives that are eco-sensitive and health protective. Consideration of the essentiality of synthetic substance […]

(Beyond Pesticides, December 18, 2025) A study in the International Journal of Hygiene and Environmental Health finds peak concentrations of organophosphate pesticide (OP) metabolites in the urine of pregnant mothers 6-12 hours after consuming contaminated fruits and vegetables. “High detection rates were observed for dimethylthiophosphate (DMTP, 96%), dimethylphosphate (DMP, 94%), diethylphosphate (DEP, 89%), and diethylthiophosphate (DETP, 77%) among 431 urine samples taken from 25 pregnant women, over two 24-hr periods, early in pregnancy,” the researchers report. The levels of metabolites within the urine correlate to the consumption of foods treated with organophosphate pesticides, highlighting the importance of adopting an organic diet—particularly for pregnant individuals and their children. “In 2009–2010, 80 pregnant women were recruited from Ottawa, Canada for the Plastics and Personal-care Product use in Pregnancy (P4) Study,” the authors say. “A subset (n = 25) collected multiple spot urines (up to 10 each; total n = 431) over two 24-h periods in early pregnancy—one weekday and weekend day—while logging their food consumption beginning 24 h prior to the first urine void and continuing through the following 24-h urine collection period.” This is the first study looking at the variability of organophosphate metabolites within 24 hours in maternal urine, giving […]

(Beyond Pesticides, December 15, 2025) With recent proposals by the U.S. Environmental Protection Agency (EPA) to register new pesticides that under international standards are classified as PFAS (Per- and Polyfluoroalkyl Substances), people and organizations are calling for Congress to reverse the agency’s action. Beyond Pesticides announced an action to Tell EPA and Congress to eliminate PFAS chemicals, including those used in pesticides.  In its action Beyond Pesticides pointed to the long history of allowing pesticides on that market that have long residual lives and bioaccumulate in the environment, causing generations of exposure and adverse effects to health and ecosystems. DDT (Dichlorodiphenyltrichloroethane) exemplifies the generational effect of a toxic pesticide whose effects ha endured for decades, even though it was hailed as a miracle solution for agriculture and public health. PFAS, with a wide variety of uses—from nonstick pans to waterproofing fabrics to firefighting foams to pesticides—might similarly lead to the characterization as a “miracle” chemical. PFAS also share the less beneficial characteristics of DDT. Like DDT, PFAS are persistent, leading to the nickname “forever chemicals,” and they are highly toxic. EPA links PFAS to an increased risk of many health effects, including decreased fertility and hypertension in pregnant people; increased risk of prostate, […]

(Beyond Pesticides, December 12, 2025) A study concluding that the weed killer glyphosate did not cause cancer was retracted last week after it was revealed in lawsuit documents that the authors did not disclose their relationship with Monsanto/Bayer. The editor-and-chief, Martin van den Berg, PhD of Regulatory Toxicology and Pharmacology, which published the article 25 years ago, wrote in the journal, “Concerns were raised regarding the authorship of this paper, validity of the research findings in the context of misrepresentation of the contributions by the authors and the study sponsor and potential conflicts of interest of the authors.”  The study, titled “Safety Evaluation and Risk Assessment of the Herbicide Roundup and Its Active Ingredient, Glyphosate, for Humans” and coauthored by three researchers in New York, The Netherlands, and Canada, was referred to as a “Landmark glyphosate safety study” in a recent article by U.S. Right to Know.   While this retraction not only sheds light on Monsanto’s influence through ghostwriting, it adds to the wide body of evidence regarding the regulatory deficiencies currently in place. The revelation is a reminder of related incidents in which Monsanto (Bayer) and other companies have wielded excessive influence at the U.S. Environmental Protection Agency (EPA), undermining the integrity of the science needed to inform the regulatory decisions that safeguard health and the environment. (See Daily News Corruption Problems Persist at EPA.)  EPA Deficiencies  In addition to the initial registration process, the Federal Insecticide, Fungicide, and Rodenticide Act (FIFRA) requires that EPA conduct a registration review of all pesticide […]

(Beyond Pesticides, December 10, 2025) On November 21, 2025, the International Agency for Research on Cancer (IARC), a branch of the World Health Organization (WHO), designated the endocrine-disrupting herbicide atrazine (as well as the herbicide alachlor) as “probably carcinogenic to humans.” Manufactured by the multinational, China-based pesticide corporation Syngenta, atrazine has been linked to various adverse health effects and runoff into waterways across the continental United States for years. Tyrone Hayes, PhD, researcher and professor of Integrative Biology at the University of California, Berkeley, who studies the endocrine-disrupting properties of atrazine and other chemicals, has said that atrazine induces cancer by turning on the enzyme aromatase. Dr. Hayes told conferees of Beyond Pesticides’ 31st National Pesticide Forum that: “[W]hat is concerning about aromatase expression and estrogen in mammals is breast cancer and prostate cancer. With regard to prostate cancer, there is an 8.4-fold increase in prostate cancer in men who work in atrazine factories and bag atrazine. There is at least one correlational study, which I didn’t publish, that shows women whose well water is contaminated with atrazine are more likely to develop breast cancer than women who live in the same community, but don’t drink the well water. (Kettles, […]

(Beyond Pesticides, December 4, 2025) In a news release last week on November 26, 2025, the U.S. Environmental Protection Agency (EPA) “issued a comprehensive fact-check addressing dangerous misinformation circulating about EPA’s recent pesticide approvals” that, according to health and environmental advocates, continues to deceive the public about the true risks for health and the environment from petrochemical pesticides including, but not limited to, per- and polyfluoroalkyl substances (PFAS). Also published on November 26, coverage titled The EPA Is Embracing PFAS Pesticides. These Are The Health Risks in Time further highlights EPA’s deficiencies and the threats of PFAS, which Beyond Pesticides has extensively covered. (See here and here.)  The controversy erupted as a result of EPA’s latest proposal to allow a new fluorinated pesticide to the list of four other similar compounds now widely available for use in homes and gardens, buildings, and agriculture. The newest pesticide proposed for EPA registration, epyrifenacil (agricultural weed killer), joins cyclobutrifluram (soil fungicide/nematicide), isocycloseram (household and agricultural insecticide), diflufenican (lawn and agricultural weed killer), and trifludimoxazin (agricultural weed killer), making a total of five PFAS pesticide proposals this year that have been associated with national and worldwide contamination of food, land, and water. Two of these, cyclobutrifluram and isocycloseram, have been approved. “Instead of constraining the use of fluorinated pesticides—persistent and highly toxic […]

(Beyond Pesticides, December 2, 2025) Recently published in Reproductive Toxicology, researchers in Denmark and Iceland investigate the impacts of pesticides on sex hormones, finding that “prenatal exposure to [the insecticide] chlorpyrifos and [weed killer] 2,4-D may affect the reproductive hormones in girls, but not boys, during minipuberty, which may have long-term implications.” Based on their analysis of urinary maternal concentrations of the pesticides and their metabolites and hormone levels in infants, the authors report, “This study examined the association between maternal pesticide exposure and pituitary, gonadal, and adrenal hormones in offspring during infancy.” The sex-specific findings highlight a public health concern with potentially long-lasting transgenerational effects. “We recruited pregnant women from 2010 to 2012 in the Odense Child Cohort, including 489 mother-child pairs,” the authors state. They continue: “Maternal urinary concentrations of the generic pyrethroid metabolite 3-phenoxybenzoic acid (3-PBA), the chlorpyrifos metabolite 3,5,6-trichloro-2-pyridinol (TCPY), and the herbicide 2,4-D were measured at gestational week 28. Serum concentrations of luteinizing hormone (LH), follicle stimulating hormone (FSH), testosterone (T), estrone (E1), estradiol (E2), 17-hydroxyprogesterone (17-OHP), Androstenedione (Adione), and Dehydroepiandrosterone sulfate (DHEAS) were assessed in infancy.” The results of the analyses show that in girls, higher maternal urinary TCPY and 2,4-D concentrations are significantly […]

(Beyond Pesticides, November 25, 2025) Chemical pollution is having a profound impact on men’s overall health and reproductive function. Endocrine-disrupting chemicals—which prominently include pesticides—are a major factor. The Health and Environment Alliance (HEAL) a European organization funded by the European Union (EU) and several private foundations, has issued a strong call for attention to – and action on – the precipitous decline in male reproductive health owing to chemical exposures, including pesticides. In a new report, Chemical pollution and men’s health: A hidden crisis in Europe, the group states, “The scientific evidence is clear. The costs of chemical pollution – human and economic – are mounting. The solutions exist. What we need now is the political will to act.” The report was written by Rosaella Cannarella, M.D., PhD, an endocrinologist at the Division of Endocrinology, Metabolic Diseases and Nutrition, University of Catania (Italy). HEAL’s report details alarming indications of catastrophe in male reproductive health: prostate cancer, testicular cancer, crashing sperm counts, and numerous developmental problems including cryptorchidism, urogenital malformations, and hypospadias. The report highlights pesticides, microplastics, phthalates, bisphenols, PFAS and heavy metals as the likely environmental sources of the crisis. There is evidence that all of these endocrine disrupting chemicals […]