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Europe Moves to Disclose and Restrict Endocrine Disruptors, While U.S. Rejects Action

Tuesday, May 2nd, 2023

(Beyond Pesticides, May 2, 2023) On April 20, the European Commission’s new rules on endocrine disrupting chemicals took effect. Called “Classification, Labelling & Packaging” (CLP), the rules create four new hazard categories for endocrine disruptors. The categories range from “suspected of causing” or “may cause” endocrine disruption in the environment to “suspected of causing” or “may cause” endocrine disruption in humans. After a transition period, users will have to indicate on labels and packaging if a substance falls into any of the hazard classes. All actors in the supply chain are obligated to provide the information to every downstream participant. The  new CLP rules, implementing a 2022 measure adopted by the European Commission and then the European Parliament, also specify a minimum font size for the hazard information and for the first time include standards for labeling in online commerce and in places where customers use refillable containers to transport, store, and use the chemicals. According to the EU Directorate-General for the Environment: “The new hazard classes are the result of extensive scientific discussions and will provide easier access to information to all users of such chemicals, notably consumers, workers and businesses. They allow further action to address and mitigate […]

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Organophosphate (OP) Pesticides in Agricultural Area Residents’ Urine Year Round

Friday, April 28th, 2023

(Beyond Pesticides, April 28, 2023) A study published in Science of The Total Environment finds agricultural communities encounter chronic and measurable pesticide exposure regardless of seasonal pesticide applications. Several biomonitoring studies demonstrate people living adjacent to or within agricultural areas often experience elevated levels of organophosphate (OP) insecticides, even while not working directly with OPs. Six dialkyl phosphate (DAP) metabolites (breakdown products) of OPs persist in urine during the spraying and non-spraying seasons. Despite 75 percent of OPs metabolizing into one or more of the six DAPs and excreting within six to 24 hours after exposure, the consistent levels of DAPs in urine highlight continuous exposure beyond regular seasonal pesticide applications. OP compounds have a global distribution, with evaporation and precipitation facilitating long-range atmospheric transport, deposition, and bioaccumulation of hazardous chemicals in the environment. OPs are highly toxic and, as this study shows, residues are consistently present in human and animal urine, as well as blood, tissues, and milk. Considering 90 percent of Americans have at least one pesticide compound in their body, primarily stemming from dietary exposure, including food and drinking water, advocates maintain that current restrictions on their use must adequately detect and assess total chemical contaminants. The study notes, “We suggest that among agricultural communities that experience […]

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Protect Bees, Trees, You and Me This Earth Day 2023

Thursday, April 20th, 2023

(Beyond Pesticides, April 20, 2023) This Earth Day (Saturday, April 22, 2023), Beyond Pesticides urges individuals to spread awareness of the toxic pesticides that poison people and the environment and the safe alternatives that are available to safeguard communities and the surrounding environment. On Earth Day, reflecting on the beauty and wonder of the natural world highlights the importance of restoration and preservation to maintain the planet’s intricate web of life. However, the natural world on which life depends is under dire threat as the dependence on toxic chemicals (e.g., pesticides) enables ongoing environmental contamination. Mechanized and industrial human activity perpetuates ongoing toxic chemical contamination, resulting in massive die-offs of beneficial organisms, increased rates of autoimmune diseases, endocrine disrupting and transgenerational chemical effects, and widespread pollution of our air and waterways. Beyond Pesticides, has the tools needed to increase environmental awareness in your community. Therefore, this Earth Day, Beyond Pesticides continues to advocate for the adoption of organic practices and policies that alleviate threats to ecosystems and enhance biodiversity. Michigan State University professor Thomas Dietz, Ph.D. highlights, “Continuing the successes of environmentalism—an integration of science, a concern with human well-being and justice, and a recognition of the need to consider […]

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Research Further Associates Widespread Atrazine Exposure to Breast Cancer

Thursday, March 30th, 2023

(Beyond Pesticides, March 30, 2023) A study published in Ecotoxicology and Environmental Safety finds that the commonly used herbicide, atrazine, promotes breast cancer development through suppression of immune cell stimulation, and thus function, and upregulation of enzymes mediating tumor development. According to the Centers for Disease Control and Prevention (CDC), breast cancer is a disease that causes breast cells to grow out of control, with the type of breast cancer depending on the cells themselves. Several studies and reports, including U.S. Environmental Protection Agency (EPA) data, identify hundreds of chemicals as influential factors associated with breast cancer risk. Breast cancer is the most common cancer among women, causing the second most cancer-related deaths in the United States. Past studies suggest genetic inheritance factors influence breast cancer occurrence. However, genetic factors only play a minor role in the incidence of breast cancer, while exposure to external environmental factors (i.e., chemical exposure) appears to play a more notable role. One in ten women will receive a breast cancer diagnosis, and genetics can only account for five to ten percent of cases. There are grave concerns over exposure to endocrine (hormone) disrupting chemicals and pollutants that cause adverse health effects. Therefore, advocates point to the need for national […]

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Local Authority to Restrict Pesticides Would Be Codified by Federal Reform Bill

Monday, February 13th, 2023

(Beyond Pesticides, February 13, 2023) As more and more communities across the country outlaw pesticides on their public land, parks, and playing fields, most states prohibit (or preempt) localities from restricting hazardous use on private property. As a result, pesticides used on landscapes—uses that can be replaced by organic management practices—result in chemical drift and runoff, putting the community in harms way and people involuntarily exposed. The Protect America’s Children from Toxic Pesticides Act of 2023 (PACTPA), S.269, includes a provision that grants communities under federal pesticide law (the Federal Insecticide, Fungicide, and Rodenticide Act—FIFRA) local authority to restrict pesticides on all property, public and private, within their jurisdiction. While the U.S. Supreme Court (in Wisconsin Public Intervenor v. Mortier) in 1991 found that FIFRA does not preempt local governments’ authority to restrict pesticide use in their town, cities, or counties, state governments have taken that authority away in 44 states at the behest of the pesticide lobby. Urge your Senators to co-sponsor PACTPA and reforms to the toxic core of FIFRA, including upholding the right of local governments to restrict pesticides. As local governments debate the hazards associated with pesticide use in their communities, many have decided to transition their […]

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Pesticide Reform Bill Reintroduced in U.S. Senate, Advocates Call Changes Major But Not Systemic Ones Needed

Tuesday, February 7th, 2023

(Beyond Pesticides, February 7, 2023) U.S. Senator Cory Booker (D-N.J.) reintroduced legislation last week to increase protections against exposure to toxic pesticides. The Protect America’s Children from Toxic Pesticides Act of 2023 (PACTPA), S.269, addresses many of the controversial issues with the Federal Insecticide, Fungicide, and Rodenticide Act (FIFRA), which governs the registration and use of pesticides in the U.S. This major reform legislation tackles some of the documented deficiencies in the regulation of pesticides and removes a number of loopholes in the law. The legislation, introduced with Senators Kirsten Gillibrand (D-NY), Bernie Sanders (D-VT), Elizabeth Warren (D-MA) and Brian Schatz (D-HI), also includes a ban on all organophosphate and neonicotinoid insecticides, as well as  the weed killer paraquat, which is known to cause Parkinson’s disease and lung fibrosis. Despite these reform provisions, the legislation does not touch the core of FIFRA’s pesticide registration process and chart a path for the systemic, transformative change that Beyond Pesticides says is essential to meet the existential challenges of current times—devastating health threats, biodiversity collapse, and the climate crisis. FIFRA, which is under the jurisdiction of the agriculture committees of Congress, has long been criticized for failing to protect the public and workers […]

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Common Fungicide Adds to Growing List of Pesticides Linked to Gastrointestinal and Microbiome Damage

Thursday, January 26th, 2023

(Beyond Pesticides, January 26, 2023) A study published in Food Safety and Toxicology finds that the widely used fungicide azoxystrobin (AZO), used in food production and turf management, can disrupt the function of the intestinal (colonic) barrier responsible for the absorption of nutrients and defense against harmful substances. This and other similar data are important because the U.S. Environmental Protection Agency (EPA), with its required pesticide testing protocol, says that the chemical has “low acute and chronic toxicity to humans, birds, mammals, and bees,” and speaks to the need for the agency to modernize its registration requirements. [The agency does note that AZO is “is highly toxic to freshwater fish, freshwater invertebrates, and estuarine/marine fish, and very highly toxic to estuarine/marine invertebrates.] AZO is a broad-spectrum chemical used in wheat, barley, oats, rye, soya, cotton, rice, strawberry, peas, beans, onions, and a long list of other vegetables, as well as on lawns and golf courses, on a range of fungal diseases. The intestinal (colonic) barrier prevents the internal environment from damage caused by exogenous toxins to ensure internal homeostasis, impeding incidences of systemic inflammatory response syndrome (SIRS), sepsis, and multiple organ dysfunction syndrome (MODS). The intestines host a group of microorganisms that form […]

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Neonicotinoid Insecticides Adversely Affect Nervous System Health, According to Study

Thursday, January 19th, 2023

(Beyond Pesticides, January 19, 2023) Research published in Environmental Health Perspectives finds the presence of nine various neonicotinoids (neonics) and six neonic metabolites within human cerebrospinal fluid (CSF). CSF is an essential part of the central nervous system (CNS), especially for CNS development. Specific chemical biomarkers (measurable indicators of biological state), like pesticides, found in CSF are useful for diagnosing and evaluating numerous neurological diseases. The nervous system is an integral part of the human body and includes the brain, spinal cord, a vast network of nerves and neurons, all of which are responsible for many of our bodily functions—from sensed to movement. However, mounting evidence over the past years shows that chronic exposure to sublethal (low) levels of pesticides can cause neurotoxic effects or exacerbate preexisting chemical damage to the nervous system. The impacts of pesticides on the nervous system, including the brain, are hazardous, especially for chronically exposed individuals (e.g., farmworkers) or during critical windows of vulnerability and development (e.g., childhood, pregnancy). Researchers identify the role agricultural chemicals play in CNS impacts causing neurological diseases, like amyotrophic lateral sclerosis (ALS) and Parkinson’s disease, dementia-like diseases such as Alzheimer’s, and other effects on cognitive function. Over 300 environmental contaminants and their byproducts, including pesticides, are chemicals commonly present in human blood […]

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Study Connects Neonicotinoids to Liver Damage Ignored by EPA

Wednesday, January 11th, 2023

(Beyond Pesticides, January 11, 2022) Neonicotinoid insecticides can have detrimental effects on liver health, according to research published in the Journal of Hazardous Materials. While this is the first study to investigate how these chemicals harm the liver, there is increasing evidence that neonicotinoids, otherwise notorious for their effects on pollinators and aquatic life, can cause direct harm to human health. As the U.S. Environmental Protection Agency (EPA) continues to protect the pesticide industry from any measure of meaningful regulation around these hazardous products, the job falls to advocates to place pressure on elected officials to make the changes necessary to safeguard long-term health and well-being. Scientists postulated that neonicotinoids are neither metabolized by the liver nor excreted by urine. To test that hypothesis, 201 individuals from a hospital in China were enrolled into a study. Of the enrolled,  81 were cancer patients, and 120 were not. These individuals underwent a procedure called endoscopic retrograde cholangiopancreatography whereby samples of their bile, a fluid produced in the liver, were retrieved and analyzed. Researchers also performed a series of blood tests, measuring a range of biomarkers, including cholesterol, bilirubin, bile acids, white blood cells, platelets, and others. Lastly, scientists determined the amount […]

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Calling for Reform of Pesticide Regulation to Address Health, Biodiversity, and Climate Crises

Monday, January 9th, 2023

(Beyond Pesticides, January 9, 2023) The Biden EPA still needs a new vision in order to meet the existential crises in public health, climate change, and biodiversity. The Trump Environmental Protection Agency (EPA) reversed in four years much of the progress made by the EPA in decades. Despite a broad new perspective embodied in President Biden’s Executive Memorandum (EM) Modernizing Regulatory Review issued on his first day in office, the Biden EPA has not adopted a new direction for regulating pesticides. Tell President Biden, EPA, and Congress to adopt a new direction for pesticide regulation. Immediately following his inauguration, President Joe Biden issued the EM, which directs the heads of all executive departments and agencies to produce recommendations for improving and modernizing regulatory review, with a goal of promoting public health and safety, economic growth, social welfare, racial justice, environmental stewardship, human dignity, equity, and the interests of future generations. This EM could reverse the historical trend of status-quo regulatory reviews required by the White House Office of Management and Budget (OMB) that typically support vested economic interests of polluters (e.g., petroleum-based pesticide and fertilizer manufacturers). The President’s EM sets the stage for the adoption of agency policy across government to […]

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EPA’s Failure to Regulate Endocrine-Disrupting Pesticides before a Federal Court. . . Again

Friday, January 6th, 2023

(Beyond Pesticides, January 6, 2023) Plaintiffs in a recent pesticide lawsuit against the U.S. Environmental Protection Agency (EPA) reprise, in their arguments, a critique proffered repeatedly by Beyond Pesticides: the agency has failed, for many years, to evaluate and regulate endocrine-disrupting pesticides adequately. The suit, according to Progressive Farmer, argues that the 1996 Food Quality Protection Act (FQPA) — legislation that mandated that EPA establish “tolerances” for pesticides in foods and regulate on those bases — required EPA to develop an endocrine disruptor screening program (EDSP) and to implement it by 1999. The litigation goes on to note that “more than twenty-five years after the passage of the FQPA, EPA has yet to implement the EDSP it created and further, has failed to even initiate endocrine testing for approximately 96% of registered pesticides.” Plaintiffs are asking the court, among other requests (see below) to order “EPA to complete all actions required under the FQPA at issue in this case as soon as reasonably practicable, according to a Court-ordered timeline.” Endocrine disruptors are chemicals that can, even at low exposure levels, disrupt normal hormonal (endocrine) function. Endocrine disruptors function by: (1) mimicking the action of a naturally produced hormone, such as estrogen […]

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Estrogen-Mediated Cancers in Humans Have Links to Endocrine Disrupting Pesticides

Tuesday, December 13th, 2022

(Beyond Pesticides, December 13, 2022) Pesticides have a long history associated with hormone (endocrine)-disrupting properties that induce various molecular changes, prompting disease development. Adding to the science, a review published in Environmental Exposure, Biomonitoring and Exposure Assessment highlights how specific estrogen-mimicking pesticides increase the risk of disease, particularly hormone-related cancers among women (i.e., breast, ovarian, endometrial cancer) and men (i.e., testicular, prostate cancer). Like pesticides, endocrine disruptors are xenobiotic (i.e., chemical substances foreign to an organism or ecosystem). Many reports demonstrate that exposure to endocrine-disrupting chemicals can adversely affect human, animal—and thus environmental—health by altering the natural bodily hormones responsible for conventional reproductive, physical, and mental development. Endocrine disruption can lead to several health problems, including hormone-related cancer development (i.e., thyroid, breast, ovarian, prostate, testicular), reproductive dysfunction, and diabetes/obesity that can span generations. Therefore, studies related to pesticides and endocrine disruption help scientists understand the underlying mechanisms that indirectly or directly cause cancer, among other health issues. Pesticides are one of the most potent xeno-estrogenic compounds, as estrogenic strength and environmental half-life exceed those of other xeno-estrogenic compounds. Focusing on organochlorine pesticides (OCs), the study evaluates the chemical effects on the physiological (anatomic) system to increase cancer risk. Using human studies, researchers assessed how estrogen-medicated cancer develops in women and men. […]

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Ocean Health: Environmental Pollutants Threaten Humpback Whale Reproduction and Offspring

Tuesday, December 6th, 2022

(Beyond Pesticides, December 6, 2022) Persistent organic pollutants (POPs)—including banned pesticides—present a health risk to humpback whales (Megaptera novaeangliae), according to a study published in Environmental Pollution. Regarding female humpback whales, levels of POPs in blubber are higher in juveniles and subadults than in adults, primarily from the transference of contaminants from the mother to her calf.  Organochlorine compounds (OCs), such as organochlorine pesticides (OCPs) and polychlorinated biphenyls (PCBs), are well-known persistent organic pollutants. The international Stockholm Convention treaty (signed by 152 countries, but not the U.S.) banned these primary pollutants of concern (UNEP, 2009) in 2001 (taking effect in 2004) because of their persistence, toxicity, and adverse effects on environmental and biological health. These pollutants have a global distribution, with evaporation and precipitation facilitating long-range atmospheric transport, deposition, and bioaccumulation of hazardous chemicals in the environment. However, these chemicals can remain in the environment for decades and interact with various current-use pesticides, including organophosphates, neonicotinoids, and pyrethroids. Although various studies demonstrate the volatile, toxic nature of POPs, much less research evaluates the impact POPs have on maternal offloading or transfer of contaminates to offspring and respective health consequences. The globe is currently going through the Holocene Extinction, Earth’s 6th mass extinction, with one […]

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Continued Reduction in Sperm Count Raises Call for Action

Tuesday, November 29th, 2022

(Beyond Pesticides, November 29, 2022) Based on new international research adding weight to previous research on falling sperm counts, it is critical that environmental agencies address this and other problems related to endocrine disruption. The study by Levine et al. finds that the drop in sperm count—a drop of 51.6% from 1973 through 2018—is global and that the rate of decline is accelerating. Tell EPA and Congress that pesticide use cannot continue without findings of no endocrine disruption.  The documented (average) drop in sperm counts is approaching the level at which the ability to cause a pregnancy begins to plummet dramatically. The reduction in male fertility may have profound psychological and social impacts, including anxiety, low self-esteem, and depression. These psychological problems have health impacts of their own. Equally serious are connections of anxiety and depression with violent behavior and suicide. Compounding the problem is the fact that men are unlikely to seek fertility-related social support. The drop in sperm counts is just one example of endocrine disruption largely due to exposure to toxic chemicals. The endocrine system consists of a set of glands (thyroid, gonads, adrenal and pituitary) and the hormones they produce (thyroxine, estrogen, testosterone, and adrenaline), which […]

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Hormone Mimicking Properties of Glyphosate Weed Killer and Related Compounds Increase Breast Cancer Risk

Friday, November 25th, 2022

(Beyond Pesticides, November 25, 2022) A study published in Chemosphere adds to the growing body of research demonstrating the endocrine (hormone) disrupting effects of glyphosate play in breast cancer development. Exposure to the herbicide glyphosate and other glyphosate-based herbicides (GBHs) at high concentrations mimics the estrogen-like cellular effects of 17β-estradiol (E2), altering binding activity to estrogen receptor α (ERα) sites, thus causing fundamental changes in breast cancer cell proliferation (abundance).  Glyphosate is the most commonly used active ingredient worldwide, appearing in many herbicide formulas, not just Bayer’s (formerly Monsanto) Roundup®. The use of this chemical has been increasing since the inception of crops genetically modified to tolerate glyphosate over two decades ago. The toxic herbicide readily contaminates the ecosystem with residues pervasive in food and water commodities. In addition to this study, literature proves time and time again that glyphosate has an association with cancer development, as well as human, biotic, and ecosystem harm. Therefore, advocates point to the need for national policies to reassess hazards associated with disease development and diagnosis upon exposure to chemical pollutants. The researchers note, “The results obtained in this study are of toxicological relevance since they indicate that glyphosate could be a potential endocrine disruptor in the mammalian system. Additionally, […]

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EPA’s Deficient Pesticide Analysis Contributes to Ecological Decline

Monday, November 21st, 2022

(Beyond Pesticides, November 21, 2022) Once again, the Environmental Protection Agency (EPA) has registered a new pesticide without performing a thorough review of its impacts on biodiversity as well as threatened and endangered species. Inpyrfluxam was registered in 2020 and only after being sued by the Center for Biological Diversity for failure to comply with the Endangered Species Act (ESA) did EPA commit to completing draft effects determinations by Fall 2022. Once again, EPA’s draft biological evaluation is incomplete and inadequate. EPA is accepting comments on its draft biological evaluation at Regulations.gov.  Tell EPA and Congress that Pesticide Registrations Require Complete Science. The Review of Inpyrfluxam is Incomplete and Inadequate.  The agency’s draft effects assessment is flawed and incomplete. We share the details because it shows that EPA is out of step with the science and its regulatory responsibility when it comes a thorough review for ecosystem effects of pesticides.   The agency used fish early life stage (ELS) tests to estimate chronic fish toxicity. This is inappropriate. The fish ELS is a sub-chronic test of sensitive life stages. Although it is often used as a surrogate or predictor of chronic toxicity, it does not adequately address potential adverse effects on reproduction or transfer of the test chemical to eggs/offspring […]

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Sperm Count Documented To Be in Substantial and Persistent Decline

Friday, November 18th, 2022

(Beyond Pesticides, November 18, 2022) A new meta-analysis, from researchers at Mount Sinai Medical Center, Hebrew University of Jerusalem, and the University of Copenhagen, among others, finds that the drop in global sperm count is accelerating and the problem has become global. The study shows that sperm count (until this study measured largely in North America, Europe, and Australia) has dropped by 51.6% from 1973 through 2018, and that the rate of decline is gaining speed worldwide.  A primary culprit, among a plexus of factors, is widespread exposure to toxic chemicals, including pesticides, in the environment. Beyond the implications for individuals and families, this global decline in sperm counts has the potential for population-level impacts and, according to Dr. Shanna Swan, an expert environmental–reproductive epidemiologist, could mean that “in the coming decades, large swaths of the global population of men could be subfertile or infertile.” Beyond Pesticides has long highlighted the relationship between reproductive anomalies and toxic pesticides, particularly the role of endocrine-disrupting (ED) compounds. Most recently, we covered a meta-study on pesticides and fertility that “finds exposure associated with lower semen quality, DNA fragmentation, and chromosomal abnormalities.” The new study is covered in Environmental Health News (EHN). From 1972 […]

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Breast Cancer Month: Neonicotinoid Insecticides and Breast Cancer Risk (Triple Negative Breast Cancer)

Thursday, October 27th, 2022

(Beyond Pesticides, October 27, 2022) A study published in Environment International adds to the growing body of research evaluating the association between neonicotinoid insecticides (neonics/NIs) and breast cancer. Past studies suggest neonics act as endocrine disruptors, affecting the development and regulation of estrogen hormones that promote breast cancer. However, this study is one of the few to evaluate the toxicological and molecular mechanisms involved in initiating breast cancer events. According to the Centers for Disease Control and Prevention (CDC), breast cancer is a disease that causes breast cells to grow out of control, with the type of breast cancer depending on the cells themselves. Most common forms of breast cancer have receptors on the cell surface that can increase cancer growth when activated by estrogen, progesterone, or too much of the protein called HER2. One in ten women will receive a breast cancer diagnosis, and genetics can only account for five to ten percent of cases. When a cancer cell lacks receptors for these molecules, G protein-coupled estrogen receptors (GPERs) are an essential biological target of estrogen and plays a role in hormone-dependent cancer development. GPERs regulate estrogen through non-genetic cellular pathways, forgoing attachment to standard molecular receptors, leading to triple-negative breast cancer (TNBC). Although past […]

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Advocates Urge Elimination of Toxic Pesticide Use to Prevent Breast Cancer

Monday, October 24th, 2022

(Beyond Pesticides, October 24, 2022) We need prevention of the causes of breast cancer, not just awareness. In 1985, Imperial Chemical Industries and the American Cancer Society declared October “Breast Cancer Awareness Month” as part of a campaign to promote mammograms for the early detection of breast cancer. Unfortunately, most of us are all too aware of breast cancer. Detection and treatment of cancers do not solve the problem. Tell EPA to evaluate and ban endocrine-disrupting pesticides, and make organic food production and land management the standard that legally establishes toxic pesticide use as “unreasonable.”  Next to skin cancer, breast cancer is the most common cancer among women, causing the second most cancer-related deaths in the United States. Genetic factors only play a minor role in breast cancer incidence, while exposure to external environmental factors such as pesticides plays a more notable role. For breast cancer, one in eight women will receive a diagnosis, and genetics can only account for five to ten percent of cases. Therefore, it is essential to understand how environmental exposure to chemicals like pesticides can drive breast cancer development. Several studies and reports, including U.S. Environmental Protection Agency (EPA) data, identify hundreds of chemicals as influential factors associated with breast cancer […]

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Pyrethroid Insecticides Associated with Liver Disease

Friday, October 7th, 2022

(Beyond Pesticides, October 7, 2022) Pyrethroid insecticides are associated with the growing worldwide epidemic of non-alcoholic fatty liver disease (NAFLD), a condition that causes swelling of the liver and can eventually lead to cirrhosis, cancer, or liver failure. According to research published in Environmental Science and Ecotechnology, exposure to pyrethroids like bifenthrin can induce gut microbiota dysbiosis (an imbalance in microorganisms in the intestines). This dysbiosis results in abnormal lipid (fat) metabolism and subsequent accumulation of lipids in liver cells, contributing to NAFLD development. Gut microbiota plays a crucial role in lifelong digestion, immune and central nervous system regulation, as well as other bodily functions. Through the gut biome, pesticide exposure can enhance or exacerbate the adverse effects of additional environmental toxicants on the body. Since the gut microbiome shapes metabolism, it can mediate some toxic effects of environmental chemicals. However, with prolonged exposure to various environmental contaminants, critical chemical-induced changes may occur in the gut microbes, influencing adverse health outcomes. Considering NAFLD is becoming the most prevalent form of liver disease, impacting at least 25 percent of the globe, and a growing body of evidence demonstrates the significance gut microbiota play in overall health, safety analyses that currently do not consider the […]

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EPA’s Failure to Ban Glyphosate Keeps Burden of Protection with Consumers and Local and State Governments

Friday, September 30th, 2022

(Beyond Pesticides, September 30, 2022) In late September, the U.S. Environmental Protection Agency (EPA) announced the withdrawal of its Interim Decision on glyphosate, the active ingredient in multiple herbicides, most notably Monsanto’s (now Bayer’s) Roundup. The action follows a slew of developments related to the herbicide, including: the 2015 International Agency for Research on Cancer’s declaration of its carcinogenicity; legal judgments and massive rewards to victims who developed cancers after chronic exposures; advocate efforts to get EPA to recognize the dangers of, and curtail, its use; and pushback from industry — most of the latter two coming in the form of litigation. The withdrawal of that Interim Decision means, on the ground that this harmful compound can continue to be used until a next regulatory review decision by EPA. Beyond Pesticides has long been engaged in education on and advocacy against glyphosate use, and was a plaintiff in the 2020 lawsuit, with the Center for Food Safety (CFS), et al., against EPA for this 2020 Interim Decision (ID). Under FIFRA (the Federal Insecticide, Fungicide and Rodenticide Act) each pesticide must be reviewed by EPA every 15 years “to ensure that existing pesticide products continue to perform their intended function without […]

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With Global Disease Rates Rising, Do Pesticides Take Some of the Blame? Science Says, “Yes.”

Thursday, September 15th, 2022

(Beyond Pesticides, September 15, 2022) A review published in Scientific African finds pesticide exposure contributes to the increase in non-communicable diseases (NCDs) in Tanzania, reflecting implications for global health. There are four main NCDs, including cardiovascular diseases, cancers, respiratory diseases, and endocrine-disrupting diseases like diabetes. These diseases have no bacterial, viral, or fungal causes, but are chronic diseases with risk factors like genetics, tobacco/alcohol use, physical activity, and diet, thus lacking transmission between people. However, research is now investigating the role environmental factors play in NCD risks, such as outdoor and indoor air pollution, exposure to chemicals, radiation, and occupation. Regardless of whether working together or separately, these risk factors contribute to NCDs and subsequent health conditions. Non-communicable diseases are on the rise, and the World Health Organization (WHO) classifies non-communicable diseases as the number one cause of death globally, affecting 41 million individuals. Moreover, WHO estimates NCD death rates to increase by 17 percent in the next decade, significantly surpassing deaths from communicable, maternal, perinatal, and nutritional diseases combined. Therefore, the report notes, “This review is informative to the policy, practices, and intervention towards the existing situation of pesticides in Tanzania. In addition, it calls for further investigation of the absence of data […]

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As Thyroid Cancer Cases Rise, Study Finds Pesticides Link

Friday, August 26th, 2022

(Beyond Pesticides, August 26, 2022) New research from a team in California finds one-third of pesticides it reviewed — including glyphosate, paraquat dichloride, and oxyfluorfen — to be associated with the development of thyroid cancer. Researchers investigated the links between exposure to pesticides — including 29 that cause DNA cell damage — and the risk of this cancer. The researchers also find that in all the single-pollutant models they employed, paraquat dichloride — a widely used herbicide — was linked to this cancer. In 2021, Beyond Pesticides covered research by the U.S. National Institutes of Health (NIH) that demonstrated that exposures to lindane and metalaxyl also cause heightened risk of thyroid cancer. These study findings add to the already considerable concern about pervasive pesticide exposure — not only among farmers and applicators, but also in the general population. It is worth noting that, in addition to elevated thyroid cancer risks, multiple pesticides can cause other health damage. Paraquat is also acutely toxic, and can cause longer-term reproductive, renal, and hepatic damage to humans; it is toxic to birds, fish, and other aquatic organisms, and slightly so to honeybees. Glyphosate, as Beyond Pesticides has written frequently, is carcinogenic, and is associated […]

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