(Beyond Pesticides, August 22, 2008) The Environmental Protection Agency (EPA) is accepting comments on letters sent from the Pesticide Action Network North America (PANNA) and Natural Resources Defense Council (NRDC) requesting that EPA revoke all tolerances for the toxic pesticide endosulfan. In addition, EPA is accepting information on endosulfan residues on commodities consumed by Alaskan natives. PANNA’s August 12 letter stated: “We are particularly concerned about the effects of endosulfan on prenatal and child development. Peer-reviewed science demonstrates that endosulfan is both an endocrine disruptor and a neurotoxicant.” The letter followed up on a February 2008 petition signed by 13,300 people across the country, a legal petition filed by the National Resources Defense Council that same month, three letters sent to the Agency on May 19, 2008 signed by 111 nonprofit environmental groups, 55 scientists, and 5 coalitions of Indigenous groups and tribes, and a lawsuit filed on behalf of PAN, environmental and farmworker groups on July 24. “Endosulfan poses a threat to the health of children in the U.S.,” the letter concluded. “This antiquated DDT-era organochlorine has already been phased out of agriculture in the European Union and at least 20 other countries. It is high time for the […]

(Beyond Pesticides, July 25, 2008) San Francisco, California —  On July 24, 2008,  a broad coalition of farmworker, public health, and environmental groups filed a lawsuit against the Environmental Protection Agency (EPA) to stop the continued use of a hazardous pesticide called endosulfan. The coalition is demanding action from EPA to protect children, farmworkers, and endangered species. Endosulfan is an organochlorine, part of the same family of chemicals as DDT, which EPA banned in 1972. Like other organochlorine pesticides, endosulfan is persistent in the environment and poisons humans and wildlife both in agricultural areas and in regions far from where it was applied. “This dangerous and antiquated pesticide should have been off the market years ago,” said Karl Tupper, a staff scientist with Pesticide Action Network. “The fact that EPA is still allowing the use of a chemical this harmful shows just how broken our regulatory system is.” Acute poisoning from endosulfan can cause headaches, nausea, vomiting, convulsions, and in extreme cases, unconsciousness and even death. Studies have linked endosulfan to smaller testicles, lower sperm production, and an increase in the risk of miscarriages. One glaring omission in the EPA’s decision is its failure to consider risks to children. A […]

(Beyond Pesticides, July 7, 2008) Officials have halted recovery efforts in the Philippines for bodies on the partially sunken ship MV Princess of the Stars after it was revealed that the ship’s cargo hull contains ten tons of the highly toxic pesticide endosulfan. The ship capsized and partially sank on June 21 in a typhoon, killing nearly 800 people onboard. Although the Philippines banned the use of endosulfan in 1993 because of its serious health effects, multi-national food companies Dole and Del Monte have maintained exemptions to the ban and continue to use endosulfan. In the wake of this tragedy, the potential for toxic contamination looms large and has raised frustrations for leaders in the government who are calling for an end to these exemptions, which benefit only foreign companies and threaten the health of the Philippine people. Globally, endosulfan has received substantial attention for its severe health and environmental effects. The European Union has submitted a petition that endosulfan be included in the Stockholm Convention, the international treaty regulating highly toxic, persistent organic pollutants. Endosulfan is banned in over 20 countries, including those of the European Union. Despite its known toxicity, endosulfan remains a commonly used insecticide and acaricide […]

(Beyond Pesticides, June 6, 2008) A recent study by the National Institutes of Health (NIH), including the National Institute of Environmental Health Sciences (NIEHS) and the National Cancer Institute (NCI), finds pesticide applicators with regular exposure to pesticides to be at a greater risk of type-2 diabetes. Published in the American Journal of Epidemiology (DOI: 10.1093/aje/kwn028), the study shows specific pesticides produce between a 20 and 200 percent increase in risk. Researchers looked at data from 31,787 pesticide applicators in North Carolina and Iowa over a period of five years. In that period, 1,171, or 3.7 percent, had developed diabetes, particularly for applicators in the highest category of lifetime days of use of any pesticide. “The results suggest that pesticides may be a contributing factor for diabetes along with known risk factors such as diabetes, lack of exercise and having a family history of diabetes,” said Dale Sandler, PhD, chief of the Epidemiology Branch of NIEHS. “Although the amount of diabetes explained by pesticides is small, these new findings may extend beyond the pesticide applicators in the study.” Freya Kamel, PhD, of NIEHS noted that “all of the seven pesticides” associated with an increased risk of type 2 diabetes are […]

(Beyond Pesticides, May 29, 2008) A study published in the May issue of Environmental Health Perspectives shows a link between prenatal exposure to the pesticide DDT and poor attention-related skills in early infancy. This study follows in a long line of recent studies associated with the negative health effects of DDT including: diabetes; non-Hodgkin lymphoma; breast cancer; and autism. Despite the fact that DDT was banned in the U.S. in 1972, concentrations of this toxic chemical’s major metabolite, DDE, have remained alarmingly high in many ecosystems, including the waters of Los Angeles County, the arctic, and even U.S. national parks. All studies documenting the health effects of DDT and chemicals in the same family, organochlorines, are particularly important not just for understanding the lingering effects of DDT from days past, but because many countries continue to employ DDT as a method in controlling mosquitoes that transmit malaria, despite its toxicity, weakening efficacy, and availability of safer alternatives. Other organochlorines are still registered for use in the U.S.The study looked at 788 mother-infant pairs who met several criteria, which included living in a town adjacent to a Superfund site in New Bedford, Massachusetts, a location with known organochlorine contamination. Cord blood […]

(Beyond Pesticides, May 27, 2008) A population-based study looking at how genes and environmental factors interact shows that pet shampoos containing insecticides may trigger autism spectrum disorders (ASD), reports New Scientist. The study findings, presented at the International Meeting for Autism Research, show that mothers of children with an ASD are twice as likely to have used an insecticidal pet shampoo during the prenatal and/or postnatal period when compared to mothers of healthy children. The strongest association was during the second trimester of pregnancy. According to the researchers, pet shampoos often contain pyrethrins and previous animal research has found that pyrethrins are designed to target the central nervous system in insects, rodents and other species and can cause death of neurons and compromise the blood-brain barrier in early life.Examining participants in the Childhood Autism Risks from Genetics and the Environment (CHARGE) study, researchers from the University of California, Davis looked at 333 children with ASD and 198 healthy children between the ages of two and five, and their families. In-depth questionnaires and blood and urine samples were collected. Isaac Pessah, Ph.D., a researcher involved in the study and professor in the Department of Molecular Biosciences, College of Veterinary Medicine at […]

(Beyond Pesticides, May 20, 2008) On May 19, 2008, scientists, Arctic tribal governments and Indigenous groups and environmental health advocates sent letters calling on the Environmental Protection Agency (EPA) to phase out the organochlorine pesticide endosulfan.“It is time to take this dangerous and antiquated pesticide off the market,” says Jennifer Sass, Ph.D., a senior scientist with the Natural Resources Defense Council. “The scientific evidence clearly shows that the continued use of this chemical puts the health of exposed farmworkers, communities and the environment at risk.” Dr. Sass is one of over 55 international scientists, medical doctors, nurses, and other health professionals urging EPA to take action on endosulfan in a letter to Administrator Stephen Johnson. Prominent scientists endorsing the letter include Philip Landrigan, M.D., M.Sc., a pediatrician and Director of the Center for Children’s Health and the Environment at the Mount Sinai School of Medicine and Ronald Herberman, M.D. and Devra Davis, Ph.D., M.P.H., researchers at the University of Pittsburgh Cancer Institute. Used in the U.S. on tomatoes, cotton and other crops, endosulfan harms the hormone system, and low levels of exposure in the womb have been linked to male reproductive harm, other birth defects and possibly autism. Acute poisoning […]

(Beyond Pesticides, May 16, 2008) Pressured by environmental organizations to protect children’s health and water quality in the Great Lakes, the Michigan House of Representatives has approved restrictions on the use of lindane, a toxic organochlorine pesticide used as a prescription drug to treat lice and scabies.  Under the legislation (HB 4569), the use of lindane  would be  prohibited except “under the supervision of a physician in his or her office if the physician considers the use of that product necessary for the treatment of a patient’s lice or scabies.” The Michigan Senate has not yet voted on the bill. Lindane has long been known for its neurotoxic properties, causing seizures, damage to the nervous system, and weakening of the immune system. It is also a probable carcinogen and endocrine disruptor. When used on people, lindane is regulated by the Food and Drug Administration (FDA). Despite the fact that it has been banned in 52 countries and restricted in over 30 more, FDA continues to allow its use in the U.S., albeit with a Public Health Advisory issued in 2003 that states, “Lindane should be used with caution in infants, children, the elderly, patients with skin conditions, and patients with […]

(Beyond Pesticides, March 31, 2008) Researchers studying related individuals who share environmental and genetic backgrounds find an association between pesticide use and Parkinson’s disease. The strongest links were between the disorder and use of herbicides and insecticides, such as organochlorines and organophosphates. The study, “Pesticide exposure and risk of Parkinson’s disease: a family-based case-control study,” was published March 28 online in the journal BMC Neurology. The research team from Duke University Medical Center and the University of Miami Miller School of Medicine Morris K. Udall Parkinson Disease Research Center of Excellence recruited 319 patients and over 200 relatives. They used telephone interviews to obtain histories of pesticide exposure, living or working on a farm, and well-water drinking. No association was found between Parkinson’s disease and well-water drinking or living or working on a farm, which are two commonly used proxies for pesticide exposures. Parkinson’s disease is a common neurological disorder affecting about 1 million people in the U.S. The disorder typically develops in later life resulting in symptoms such as tremors and muscle rigidity. Although variations in several genes have been identified that contribute to the disease, these rare genetic defects account for a small proportion of the overall prevalence […]

(Beyond Pesticides, March 12, 2008) BioDiversity Research Institute, a nonprofit ecological research group, released a new report that was presented March 12, 2008 to Maine’s Joint Standing Committee on Natural Resources. Entitled “Contaminant Screening in Maine Birds,” it documents over 100 harmful contaminants that were found in Maine bird eggs. Scientists collected 60 eggs, representing 23 species of birds, all of which test positive for chemical contaminants, some at levels believed to be harmful to the birds. Flame retardants (PBDEs), industrial stain and water repellants (PFCs), transformer coolants (PCBs), pesticides (OCs), and mercury are found in all 23 species of birds tested. The bird species studied live in a variety of habitats: on Maine’s ocean, salt marshes, rivers, lakes and uplands. “This is the most extensive study of its kind to date and the first time industrial stain and water repellants were discovered in Maine birds,” says report author, senior research biologist Wing Goodale with the Institute. The Common loon, Atlantic puffin, piping plover, belted kingfisher, great black-backed gull, peregrine falcon and bald eagle have the highest contaminant levels. The flame retardant deca-BDE, banned last year in Maine, is found in eight species. Overall, eagles carry the greatest contaminant load, […]

(Beyond Pesticides, February 5, 2008) Whether you love it or hate it, Valentine’s Day is less than ten days away. Millions of flowers and chocolates will soon be bought and given to loved ones. Unfortunately, these gifts come at a cost much higher than the one on the price tag. Conventional roses and chocolate sold in the United States are produced using toxic pesticides, with little regard for the workers or the environment.The United States imports about 70 percent of its flowers from foreign countries, mostly from Ecuador and Columbia. Roses analyzed in the past few years were found to contain a myriad of harmful pesticides that ranged from organophosphates such as Dimethoate, carbamate- Aldicarb, to organochlorines like Captan, Bravo, Tedion, Iprodione and Procymidone. Organophosphates are considered to be the most likely pesticide to cause an acute poisoning. They are a highly toxic class of pesticides that affect the central nervous, cardiovascular and respiratory systems. Symptoms of exposure include: numbness, tingling sensations, headache, dizziness, tremors, nausea, abdominal cramps, sweating, incoordination, blurred vision, difficulty breathing, slow heartbeat, unconsciousness, incontinence, convulsions and fatality. Some organophosphates have been linked to birth defects and cancer. Organochlorines are known estrogenic pesticides and have been linked […]

(Beyond Pesticides, January 29, 2008) University of Cambridge scientists say there may be a link between persistent organic pollutants (POPs), including pesticides, and Type 2 Diabetes. The Cambridge scientists are advocating additional research into the little understood links between environmental pollution and adult onset diabetes. In the most recent edition of the journal Lancet, Oliver Jones, Ph.D., and Julian Griffin, Ph.D., highlight the need to research the possible link between persistent organic pollutants (POPs, a group which includes many pesticides) and insulin resistance, which can lead to adult onset diabetes. In their commentary, Dr. Jones and Dr. Griffin cite peer reviewed research including that of D. Lee, et al, which demonstrated a very strong relationship between the levels of POPs in blood, particularly organochlorine compounds, and the risk of type 2 diabetes. “Of course correlation does not automatically imply causation,” says Dr. Jones. “But if there is indeed a link, the health implications could be tremendous. At present there is very limited information. Research into adult onset diabetes currently focuses on genetics and obesity; there has been almost no consideration for the possible influence of environmental factors such as pollution.” Interestingly, in the Lee study an association between obesity and […]

(Beyond Pesticides, January 14, 2008) Researchers at the Indian Institute of Technology (IIT) Madras have developed nanoparticles that can remove organochlorine pesticides from drinking water. These chemicals are quite persistent in the environment and difficult to remove from water. Notorious organochlorines include DDT, endosulfan, HCH (hexacholorcyclohexane) and aldrin, all of which have known health and/or environmental hazards. Many of these chemical pesticides are used heavily in agriculture and taint India’s water. Though no comprehensive national survey has been done, isolated studies show contamination of groundwater and river systems that cannot be removed by standard water filters. “Even though some of these pesticides have been banned, they are very much present in the environment. For instance, endosulfan has an environmental lifetime of 100 years,” said Thalappil Pradeep, professor of chemistry at IIT Madras. He leads the research that has shown that nanoparticles, mostly from gold, silver, copper and several oxides, are effective at removing endosulfan even at very low concentration. “Efficient chemistry at low concentration is important so that even if one molecule of the pesticide passes by, it gets removed by the nanoparticle,” said Pradeep. He holds a US and an Indian patent and has licensed part of the technology […]

(Beyond Pesticides, December 17, 2007) People exposed to banned organochlorine pesticides and other toxic chemicals that persist in the environment are more likely to develop non-Hodgkin lymphoma (NHL), according to new research funded by the British Columbia Cancer Agency. The study, “Organochlorines and risk of non-Hodgkin lymphoma”, was published in the International Journal of Cancer on December 15, 2007 and is so far the largest to examine organochlorines in plasma and their link to illness. The researchers measured the levels of pesticides or pesticide metabolites and congeners of polychlorinated biphenyls (PCBs) in the blood of 880 British Columbians, half with NHL and the other half control subjects. Several pesticide analytes and a number of congeners showed a significant association with NHL. Non-Hodgkin lymphoma is the fifth most common cancer in Canada and the most common type of lymphoma. “We know that the incidence of non-Hodgkin lymphoma has been steadily rising for the past 30 years worldwide, but there hasn’t been clear evidence to explain the increase,” says Dr. John Spinelli, Ph.D., lead author and a senior scientist at the BC Cancer Agency. “Our study helps to provide answers to this puzzle by showing a strong link between these specific environmental […]

November 13, 2007) Autism is on the rise, both in prevalence and incidence, and there is growing evidence that environmental insults, such as pesticides, are linked to this developmental disability. According to the latest study, published in the October issue of Environmental Health Perspectives, children born to mothers living near fields where pesticides are applied are more likely to develop autism spectrum disorders (ASDs). The authors of “Maternal Residence Near Agricultural Pesticide Applications and Autism Spectrum Disorders among Children in the California Central Valley” compared maternal pesticide exposure for 465 children with ASDs and 6,975 children without ASDs living in the same area. The research reveals that mothers who lived within 500 meters of fields sprayed with organochlorine pesticides, specifically endosulfan and dicofol, during their first trimester of pregnancy had a six times higher chance of having children with autism compared to mothers who did not live near the fields. Mark Horton, M.D., director of the California Department of Health, said the findings are exploratory and indicate that more research of the relationship between organochlorines and ASDs is needed. (See Daily News Blog posting from July 31, 2007 for further reactions from health care officials and more details about this […]

(Beyond Pesticides, July 31, 2007) Preliminary research into birth records and pesticide data reveal that mothers who were within 500 meters of fields sprayed with organochlorine pesticides during their first trimester of pregnancy were six times higher to have children with autism compared to mothers who did not live near the fields. Scientists from the California Department of Public Health conducted the study, which is available online in Environmental Health and Perspectives, entitled, “Maternal Residence Near Agricultural Pesticide Applications and Autism Spectrum Disorders Among Children in the California Central Valley.” The study, initiated to “systemically explore the general hypothesis that residential proximity to agricultural pesticide applications during pregnancy could be associated with autism spectrum disorders in offspring,” found that 28% of the mothers studied who lived near fields in Central Valley, which were sprayed with organochlorines, such as endosulfan and dicofol, have children with autism. However, officials are quick to point out that their findings are preliminary. “We want to emphasize that this is exploratory research,” says Dr. Mark Horton, M.D., director of the California Department of Health. “We have found very preliminary data that there may be an association. We are in no way concluding that there is a […]

(Beyond Pesticides, July 9, 2007) New field and laboratory research reveals that organochlorine pesticides reduce the hatching rate of alligator eggs. This finding adds to previous studies demonstrating that pesticides cause endocrine disruption in alligators, resulting in poorly developed reproductive organs. American alligators, which were delisted from the endangered species list in the late 1980s, are still experiencing low hatching rates around contaminated wetlands. In Florida, many wetlands were converted or are adjacent to farmlands and some farmlands have been restored back into wetlands in efforts to improve ecosystem health. Agricultural runoff has altered the surrounding aquatic environments by depositing pesticide residuals and skewing nutrient levels. Organochlorine pesticides, such as chlordane, toxaphene and dieldrin, have been especially problematic due to their persistent nature. The link between pesticides and reproductive problems in alligators has been firmly established since the 1990s. University of Florida zoologist Louis Guillette, Ph.D., found pesticides are linked to smaller penises and abnormal egg development in exposed alligators. Florida Fish and Wildlife Conservation Commission official Allan Woodward has also observed fewer hatches around lakes with high pesticide levels. He reports the hatching rate has improved around Lake Apopka, a large lake in central Florida, during the last two […]

(Beyond Pesticides, July 2, 2007) Dangerous pesticides have been found in soil samples taken from the grounds of the West Brook Middle School in Paramus, New Jersey. The concentrations found exceed state safety standards and concerns are being raised over why the school took no action once it knew about the contaminants. One of the chemicals found is chlordane. Chlordane is an organochlorine classified by the EPA as a Group B2, probable human carcinogen and is also associated with adverse neurological and gastrointestinal effects. Studies also report an association between chlordane exposure and non-Hodgkins’s lymphoma. Chlordane was registered in the U.S. in 1948 and was used as a pesticide on agricultural crops and gardens until 1978 when its registered uses on food crops and other above ground uses were cancelled. In 1988, all uses of chlordane were cancelled. This pesticide however, is persistent in soil and the environment and has been found in air samples, fish tissue, and recent studies have linked organochlorines like chlordane to breast cancer. The Record, a New Jersey newspaper, commissioned the tests to be carried out by Aqua Pro-Tech Laboratories, which revealed that chlordane at 17 parts per billion were on the school’s soccer field. […]

(Beyond Pesticides, June 8, 2007) New research shows that pesticides can reduce the efficiency of nitrogen-fixing plants, impacting soil fertility and ultimately reducing crop yields. The insecticides methyl parathion, DDT and pentachlorophenol were among the chemicals found to inhibit or delay the symbiotic relationship between the legume alfalfa and rhizobia bacteria, which is crucial to nitrogen fixation. Legume crops are often cultivated to help replenish the vital soil nutrient nitrogen (N), but legumes cannot achieve this on their own — Rhizobium bacteria interacts with legumes to convert atmospheric N to nutrient compounds utilizable by plants. Legumes like alfalfa and soybeans are often included in crop rotations due to this beneficial relationship. Nitrogen fixation resulting from the symbiotic relationship between leguminous plants and species of Rhizobium bacteria is an ecological service estimated to be equivalent to $10 billion worth of synthetic N fertilizer annually. Symbiotic nitrogen fixation (SNF) reduces the need for synthetic fertilizers, which cause environmental problems such as impaired water quality. Acknowledging that SNF is both initiated and maintained by chemical signals between the host plant and the beneficial bacteria, the research team postulated that natural and synthetic chemicals could disrupt these signals. The study shows “previously undescribed in […]

(Beyond Pesticides, May 22, 2007) In a study published in the latest issue of Environmental Toxicology and Chemistry, scientists found that seafood products from southern China contain high concentrations of DDT and hexachlorocylohexane (HCH). While banned in China since 1983, humans are being exposed to organochlorine pesticides (OCP) at rates high enough to pose health threats. The study responded to high rates of DDT and HCH found in sediment, water and biota in the Pearl River delta and neighboring coast, where land is being rapidly industrialized, urbanized, and transferred from agriculture to commercial development. Researchers tested 212 seafood products, including shrimp, crabs, and mollusks, from 11 coastal cities for 21 OCPs, including DDT, HCH, heptachlor, dieldrin, and endosulfan. The highest concentrations of DDT were found in four species of shellfish, although concentrations varied widely depending on sampling location. The study reported, “These results suggest that bioaccumulation of DDTs in seafood products was highly species-specific, probably due to different feeding habits and habitats.” By taking a large sample of one indicator species, it also concluded “the coastal region of southern China is probably one of the most DDT-polluted areas in the world.” Researchers also found HCH to be more widely prevalent […]

(Beyond Pesticides, April 10, 2007) Scientists have reported several environmental estrogens can affect the immune system, promoting allergic diseases such as asthma. Researchers have observed this response using pesticides and other environmental contaminants. Focusing on six environmental estrogens (xenoestrogens), researchers were able to reveal how these contaminants affect the immune system. Using doses representative of present human exposures, these estrogen-mimics were tested on human and mouse cells. The observed effect of exposure was both an increase in speed and intensity of immune reactions. Three of the environmental estrogens tested were organochlorine pesticides or metabolites: endosulfan, dieldrin and DDE (DDT metabolite). The other contaminants included nonylphenol, a by-product of plastics manufacturing, and two PCBs. The study reveals that the accelerated and increased level of degranulation of mast cells is the mechanism that causes more severe allergic reactions than would otherwise take place. According to Environmental Health News, mast cells play a vital role in allergic reactions because they are primed by past experience with allergens to release inflammatory agents into the body, which causes an allergic reaction. If the mast cell has been primed to react to a specific allergen, it will degranulate, releasing molecules such as histamine. The more intense […]

(Beyond Pesticides, February 8, 2007) Investigators at St. Jude Children’s Research Hospital have shed new light on the suspected role of pesticides in the development of Parkinson’s disease (PD). The study, “GST expression mediates dopaminergic neuron sensitivity in experimental parkinsonism” appearing in the Proceedings of the National Academy of Sciences (January 31, 2007), illustrates the mechanism of nerve cell damage by pesticide exposure. The enzyme that prevents damage to the substantia nigra, the part of the brain where nerve cell damage associated with PD occurs, is called GST pi (“pie”). This enzyme stands like a sentry at the crossroads of several biochemical pathways, any one of which can lead to PD. GST pi protects the nerve cell from death caused by either environmental toxics, such as pesticides, or a self-destruction process called apoptosis (cell suicide), triggered by certain stressful conditions in the cell. If GST pi levels are reduced or this enzyme is overwhelmed by toxics, these nerves are at increased risk of death, according to studies in mouse models. GST pi is one of a family of similar enzymes that eliminate free radicals generated by pesticides and other chemicals. Two members of this family are present in the brain, […]

(Beyond Pesticides, January 30, 2007) Breast cancer groups across the country have a new issue to add to the repertoire of risk factors: Pesticide use. A study published online in the American Journal of Epidemiology has found a strong link between residential pesticide use and breast cancer risk in women. Responding to the study, Susan Teitelbaum, Ph.D., assistant professor in the department of community medicine at the Mount Sinai School of Medicine in New York, says the options are simple”” “Stop using pesticides.” The study, published December 13, is the first to examine the relation between breast cancer and pesticides through self-reported residential pesticide use. Using women from New York, the study looks not at one or two incidents of pesticide contact, but at the impact of lifelong pesticide use in the home, lawn and garden. Using a sample of 1,508 women who were diagnosed with breast cancer between 1996 and 1997, the study compares these women to 1,556 control subjects who were randomly selected. The results show that those women whose blood samples had higher levels of organochlorines are at an increased risk of breast cancer. Organochlorines are a broad class of chemicals, including DDT, dieldrin, and chlordane, and […]