(Beyond Pesticides, September 15, 2025) With residues of the widely used weed killer glyphosate (Roundupᵀᴹ) in the food supply long documented, scientific attention has turned to the synergistic effects of the weedkiller— a magnified effect greater than the individual chemical effects added together. The authors of an article in World’s Poultry Science Journal write, “The synergistic toxic effects of commercial glyphosate formulations and their bioaccumulation in animal tissues are often overlooked in current safety assessments.” Following up on a previous action, Beyond Pesticides is telling Congress and the U.S. Environmental Protection Agency (EPA) that the agency must consider the effects of pesticides in the context in which they are used and promote the organic alternative.  Glyphosate residues in animal feed, as well as in water and through other exposure routes from food generally and residential areas, pose risks to both animal and human health, as these residues can bioaccumulate. As previously examined by Beyond Pesticides, the effects of pesticides are not limited to the crops to which they are applied. Synergistic effects of multiple chemical exposures are the rule, rather than the exception.   With poultry, the herbicide enters the production system through residues in genetically engineered feed. An earlier article in Scientific Reports concludes that glyphosate’s […]

(Beyond Pesticides, September 10, 2025) After being criticized by the chemical industry and allied agribusiness and service industry groups on the Make America Healthy Again (MAHA) report in May, the strategy document, released yesterday, has tamped down efforts to reform government programs that regulate pesticides. There are no specific recommendations on improving the regulation of pesticides. Rather, the strategy appears to embrace business-as-usual and could even ramp up government efforts to tout the need for pesticides and claims that current regulatory reviews are effective and comprehensive. In a section of the strategy entitled “Increasing Public Awareness and Knowledge,” the document says: “EPA, partnering with food and agricultural stakeholders, will work to ensure that the public has awareness and confidence in EPA’s pesticide robust review procedures and how that relates to the limiting of risk for users and the general public and informs continual improvement.” This is at odds with the earlier MAHA assessment report which identified pesticides as substances of concern that, citing deficiencies in chemical reviews, “may be neglecting potential synergistic effects and cumulative burdens, thereby missing opportunities to translate cumulative risk assessment into the clinical environment in meaningful ways.” While the earlier report, Make Our Children Healthy Again: Assessment, […]

(Beyond Pesticides, August 22, 2025) Legislative language moving through Congress—intended to prevent farmers, consumers, and workers from holding pesticide manufacturers accountable for the harm caused by their toxic products—is being opposed by a broad coalition of farmers, beekeepers, consumers, environmentalists, and workers with the release today of a joint statement opposing a dramatic change in a fundamental legal right. The document, Protect the Right of Farmers, Consumers, and Workers to Hold Pesticide Companies Accountable for Their Harmful Products, is joined by 51 organizations, coalitions, businesses, and leaders representing tens of thousands of members and communities. The legislation at issue is hidden in a provision of the Appropriations bill (Section 453) that has passed through the Appropriations Committee in the U.S. House of Representatives and is headed for a vote of the full House in the next couple of weeks, followed by the U.S. Senate. The Appropriations provision is being pushed by chemical companies in the wake of extraordinary jury verdicts against Bayer/Monsanto, amounting to billions of dollars in compensatory and punitive damages, for “failure-to-warn” liability claims involving glyphosate (Roundupᵀᴹ) weed killer products. The pesticide has been classified as cancer-causing by the International Agency for Research on Cancer (a part of […]

(Beyond Pesticides, August 15, 2025) In analyzing the data present in an article in Data in Brief, concerning levels of pesticide biomarkers are present in the urine of adolescents and young adults that are linked to numerous health implications. The biomonitoring data, collected at two time points from participants in a longitudinal cohort study in the agricultural county of Pedro Moncayo, Ecuador, encompasses a total of 23 compounds used as herbicides, insecticides, and fungicides and their associated metabolites (breakdown products), which include organophosphates, pyrethroids, and neonicotinoids. The results highlight the disproportionate risks to a Latin American population that occur as a result of living in areas with heavy chemical-intensive agriculture. “This article presents urinary pesticide metabolite concentrations for 665 participants in the ‘Study of Secondary Exposure to Pesticides among Children, Adolescents, and Adults’ (ESPINA), which were collected during two follow-up assessments,” the authors describe. The first sampling period from July to October 2016, referred to as Follow-up Year [FUY]-8b, includes 529 of the participants, while the second sampling period from July to September 2022 (FUY-14a) includes 505 of the participants. All participants are within the agricultural community of Pedro Moncayo. As the authors note, “The ESPINA study aimed to include […]

(Beyond Pesticides, August 14, 2025) A review in Clinical and Experimental Obstetrics & Gynecology links various classes of environmental pollutants including pesticides and per- and polyfluoroalkyl substances (PFAS), both of which Beyond Pesticides has extensively covered, to adverse effects on the female reproductive system and common mechanisms of toxicity. These chemicals “disrupt the hypothalamic-pituitary-gonadal axis (HPG), impair ovarian function, and contribute to reproductive dysfunction through mechanisms such as oxidative stress, hormonal disruption, and epigenetic [gene expression or behavior] modifications,” the authors say. This leads to menstrual irregularities, infertility, and pregnancy complications, as well as increases in the risk of reproductive system disorders such as endometriosis, polycystic ovary syndrome (PCOS), and ovarian cancer, among others. “Additionally, transgenerational effects mediated by epigenetic modifications, germ cell damage, and placental transfer may adversely affect offspring health, increasing the risk of reproductive dysfunction, neurodevelopmental disorders, metabolic diseases, and cancer,” the researchers explain. This study, integrating recent epidemiological and experimental findings, provides an overview of major chemical classes that threaten women’s health and highlights the need for immediate action. As the authors point out, female reproductive health is important not only for those who choose to plan for a family but also for the overall well-being […]

(Beyond Pesticides, August 12, 2025) Last week on August 9, the United Nations observed International Day of the World’s Indigenous Peoples, a critical acknowledgement of Indigenous “food sovereignty, food security, biodiversity conservation and climate resilience,” as outlined in the report of the Expert Mechanism on the Rights of Indigenous Peoples, Eighteenth Session (July 14–18, 2025). As the report states, under Article 20 of the UN Declaration on the Rights of Indigenous Peoples, “Indigenous Peoples possess distinct economic systems rooted in traditional knowledge, practices and resources and have the right to sustain, strengthen and develop these systems in accordance with their cultures, traditions, values and aspirations.” It continues, “When deprived of their means of subsistence and development, this article provides that Indigenous Peoples are entitled to just and fair redress.” In a statement recognizing the importance of the day, Special Rapporteur on the rights of Indigenous Peoples, Albert K. Barume, focuses on the need for Artificial Intelligence (AI) to recognize that, “Indigenous Peoples have long been stewards of knowledge, biodiversity, and sustainable living [and] [w]ithout their meaningful participation, AI systems risk perpetuating historical injustices and deepening the violation of their rights.” Meanwhile, the current U.S. administration has shifted away from federal […]

(Beyond Pesticides, August 7, 2025) The novel study published in Arthritis & Rheumatology is the largest investigation of rheumatoid arthritis (RA) in women to date, finding evidence of heightened risks when exposed to insecticides through data collected from over 400 eligible women in the Agricultural Health Study (AHS). AHS participants include a cohort of thousands of licensed pesticide applicators and their spouses from Iowa and North Carolina, with this particular study as the first to consider the link between pesticide exposure and RA as it affects women’s health.   “Growing evidence suggests farming and agricultural pesticide use may be associated with rheumatoid arthritis (RA), but few studies have examined specific pesticides and RA among farm women, who may personally use pesticides or be indirectly exposed,” the study authors explain. The findings reveal that organochlorine insecticides that continue to persist in the environment, as well as organophosphate and synthetic pyrethroid pesticides used in public health or residential settings, correlate with RA diagnoses in women.  As shared in previous Daily News, for the most part organochlorine pesticides, including dichlorodiphenyltrichloroethane (DDT), are no longer used worldwide, but the legacy of their poisoning and contamination persists. These compounds are primarily made up of chlorine atoms, […]

(Beyond Pesticides, July 31, 2025) A study published in Environmental Advances finds that hundreds of honeybee hives across central and northern Italy are contaminated with various pesticides and their metabolites, including glyphosate and fosetyl.  “There was no significant difference in glyphosate presence between dead/dying and live bees, suggesting chronic exposure rather than acute toxicity. However, higher pesticide concentrations in dead/dying bees indicate potential sublethal effects contributing to colony distress,” according to the authors. This peer-reviewed study builds on the mounting evidence outlined in the literature connecting pesticide residues to nontarget harm to pollinators and other insects and animals that are critical to biodiversity. Background and Methodology “The primary objectives of this study were to develop and validate a reliable, sensitive method for analyzing polar pesticides [highly soluble in water] in honeybees and to investigate polar pesticides residue levels in honeybees across northern and central Italy,” say the researchers of this study, who conduct research at the Experimental Zooprophylactic Institute of Lombardy and Emilia Romagna “Bruno Ubertini”, Experimental Zooprophylactic Institute of Umbria and Marche “Togo Rosati”, and Experimental Zooprophylactic Institute of Lazio and Tuscany “M. Aleandri.” 314 honeybee samples were gathered voluntarily from local beekeepers in six regions of northern and […]

(Beyond Pesticides, July 8, 2025) A commentary published in Science of The Total Environment showcases the occupational and environmental exposure pathways of fossil-fuel-based pesticide and fertilizer products that children across the globe face, particularly in rural areas of low- and middle-income countries. The authors underscore “the urgent need for multi-level systemic change, resilient health systems, and active stakeholder engagement,” which includes “support for safer and more sustainable agricultural practices.” This includes specific asks for governments “to offer technical assistance to producers and encourage organic and agroecological practices to ensure both environmental justice and food security.” Organic food systems, and criteria for land management systems more broadly, are critical to addressing the triple crises of biodiversity loss, public health collapse, and climate emergency. Organic law, as defined in the Organic Foods Production Act (OFPA) of 1991, is designed as a participatory process with accountability and transparency integral to the statutory language. The law creates the National Organic Standards Board (NOSB), comprised of farmers, consumers, and conservation organizations, a scientific expert, an organic certifier, and a retailer with the statutory authority to adopt binding recommendations to the Secretary of Agriculture on the National List of Allowed and Prohibited Substances. Simultaneously, the public […]

(Beyond Pesticides, June 19, 2025) Juneteenth, officially recognized as a federal holiday since 2021, commemorates the arrival of Union soldiers in Galveston, Texas, to free enslaved people per the Emancipation Proclamation that was issued two and a half years prior. While June 19, 1865, does not mark the legal end of slavery nationwide, it was a crucial moment in the fight for freedom and continues to highlight the ongoing fight for human rights, equality, and environmental justice.   As Beyond Pesticides has previously shared in the Daily News, this commemorative day is a time for individuals and organizations to acknowledge and reflect on their past and current actions or inactions that perpetuate systemic racism. The father of environmental justice, Robert Bullard, Ph.D., defines environmental racism as any policy or practice that unequally affects or disadvantages individuals, groups, or communities based on their race. Dr. Bullard states that, until the 1980s, environmental conservation and pollution were separate. Many environmental organizations prioritized the preservation of “wilderness” rather than urban areas, predominantly comprised of POC, who continuously experience the disproportionate impacts of pollution and the effects of environmental racism.   Sharing the Science  A recent study regarding the intersections of urban planning, wildlife management, […]

(Beyond Pesticides, June 12, 2025) Thailand-based researchers, in a study published in BMC Veterinary Research, found significant documentation of the occurrence of anticoagulant rodenticide (AR)-induced toxicosis for nontarget organisms in the country. This includes the finding that “all submitted samples of suspected AR exposure in wild animals and exotic pets tested positive for ARs.” These findings signal the pervasive nature in which agrichemical products, including anticoagulant and nonanticoagulant rodenticides, encroach on broader ecosystem health. In an era of federal deregulation and increasing public scrutiny of the role of government in addressing public health, biodiversity, and the climate crisis, advocates continue to call for a wholesale transition to organically managed food and land management systems. Background and Methodology  “In this retrospective study, we investigated the occurrence of AR poisoning in animal specimens analy[z]ed at the Department of Veterinary Pharmacology, Faculty of Veterinary Science, Chulalongkorn University (DVPCU), between 2018 and 2023,” say the authors on the primary focus of this study. “This study aims to provide a reference dataset for future research on the epidemiology of AR toxicosis in nontarget species.” The authors declared that there were “no competing interests” in engaging in this research.  The anticoagulant rodenticides were detected through two […]

(Beyond Pesticides, June 11, 2025) Researchers developed a novel tool* in a recent study published in Nature Communications this year that successfully creates a map of the “pesticide-gut microbiota-metabolite network,” identifying “significant alterations in gut bacteria metabolism.” While the study authors acknowledge that this is not a complete map, since they selected specific pesticides and bacterial partners, the research adds to the body of peer-reviewed scientific literature that underscores the relationship between pesticide residues and human gut health. Organic farmers, as well as any land steward invested in agroecological practices and soil health, understand that microbial life (both in the body and in the soil) is dangerously undermined by the status quo of chemical-intensive land management. Background and Methodology The researchers leverage mass spectrometry to test metabolite (metabolomics) and lipid (lipidomics) relationships with pesticide residues, as well as an in vivo mouse model. *The map itself is a form of computational biology, which advocates have warned could be a false solution if not accompanied by other proven scientific methods. See here for analysis by the Natural Resources Defense Council on risks of unproven methods such as New Approach Methodologies [NAMs]. All major phylogenetic (“evolutionary relationships among biological entities”) groups are […]

(Beyond Pesticides, June 5, 2025) A study conducted in Pennsylvania and published in Environmental Entomology highlights threats to nontarget organisms from neonicotinoid insecticide exposure. Using species of ground beetles as an example, the study documents sublethal behavioral effects as well as decreased week-long survival. This research fills a notable gap in current research, with the authors explaining, “Predatory soil arthropods are under-represented in insecticide toxicity studies, severely limiting our understanding of how insecticides affect soil-invertebrate communities in agroecosystems.”   The researchers continue, “As a step toward addressing this issue, we conducted novel acute oral, topical, and soil-based toxicity assays on 9 ground beetle species (Coleoptera: Carabidae) in response to the neonicotinoid insecticides clothianidin, thiamethoxam, and imidacloprid.” The nine carabid beetle species, all common to agroecosystems in central Pennsylvania, were exposed to clothianidin, while additional assays with thiamethoxam and imidacloprid were conducted on the two most abundant species. A wide body of science exists that connects neonicotinoid exposure to health effects in a variety of nontarget organisms. Neonicotinoids, a class of neurotoxic insecticides, act as agonists of nicotinic acetylcholine receptors, “persist under field conditions, and are water soluble, enabling them to translocate into plants and provide systemic protection of seedlings,” the […]

(Beyond Pesticides, May 30, 2025) The Making America Healthy Again (MAHA) Commission report, Make Our Children Healthy Again: Assessment, published on May 23, drew criticism from the pesticide industry and agribusiness allies for pointing to independent science that identifies a range of pesticide-induced health hazards.* The Commission, chaired by Robert F. Kennedy, Jr., Secretary of the Department of Health and Human Services (HHS), is composed of the heads of numerous agencies of the federal government and the White House, from the U.S. Environmental Protection Agency (EPA), the U.S. Department of Agriculture (USDA), and the Office of Management and Budget (OMB), to the Assistant to the President and Deputy Chief of Staff for Policy Stephen Miller. The MAHA Commission was established by Executive Order 14212 on February 13, 2025. Despite extensive citations to the science on pesticide hazards, the report includes a section on “Crop Protection Tools,” in which there is a repetition of chemical industry talking points that pesticide residues in food comply with existing tolerances, thus implying that pesticides in food are safe. (See USDA Pesticide Data Program Continues to Mislead the Public on Pesticide Residue Exposure.) However, overall the report’s introduction sets a tone that seeks to catalogue […]

(Beyond Pesticides, May 9, 2025) Research in Advances in Modern Agriculture showcases how pesticide residues can threaten the health of soil nematodes and cause phytotoxic effects in cucumber plants. In assessing both the sprayed vegetables and the organisms within the soil, the authors find a negative correlation between pesticide exposure and soil nematode populations that is proportional to the application rates of the chemicals, as well as alterations in plant development. These impacts highlight potential wider effects on crop productivity, biodiversity, and human health. “Nematodes, which are microscopic worms inhabiting the soil, are vital contributors to soil vitality and the cycling of nutrients,” the authors share. “Nonetheless, the non-selective and widespread application of pesticides can negatively impact these organisms, leading to potential detriments in soil quality and plant vitality.” “Pesticide residues have the propensity to be absorbed and progressively accumulate as they traverse from soil to plants and subsequently to humans,” the researchers state. They continue, “The specific characteristics of the pesticide and its interactions with the body across different levels dictate whether it will be excreted without causing significant harm or if it will accumulate, potentially leading to enduring subclinical and clinical ramifications.” The impacts vary widely between organisms […]

(Beyond Pesticides, April 25, 2025) A novel study in Chemosphere finds impacts on male fertility in a bee species (Osmia bicornis) with exposure to sulfoxaflor, a systemic sulfoximine insecticide with similar mechanisms to neonicotinoids. “For the first time, we demonstrate that short-term chronic, field-realistic exposure to a common pesticide reduced pre-copulatory display (36%) and sounds (27%) [courtship behaviors], increased the number of copulations (+110%) and the mating duration (+166%), while finally reducing sperm quantity (25%) and mating success (43%),” the researchers report. They continue, “Our research raises considerable concern on the impact of field-realistic, low sublethal pesticide levels on the fertility and reproductive success of pollinators.” Mating behaviors and the ability to successfully reproduce determines the survival of species. As the authors state: “Mating disorders may therefore contribute to the recent decline in insect and pollinators’ health worldwide. While the impact of pesticides on pollinators is widely considered as a driving factor for reducing pollinators’ health, their effect on mating behaviour and male fertility remains widely overlooked.” The red mason bee (O. bicornis) can “provide essential pollination service for both crops and wild plants sustaining food production and biodiversity while serving as a bioindicator of environmental health.” The abundance and […]

(Beyond Pesticides, April 23, 2025) Recent reviews of scientific literature, in both Chemosphere and Reports in Public Health, associate Parkinson’s disease (PD), the second most prevalent neurodegenerative disease globally, with pesticide exposure. “Given the pervasive nature of pesticide residues in everyday food consumption and inadequate monitoring of their long-term toxicological impacts, the role of pesticide exposure as a modifiable risk factor for neurological disorders, including PD, warrants urgent attention,” the researchers state in the article in Chemosphere. In describing the history of Parkinson’s and previous research, the authors in Reports in Public Health note that while PD etiology is not fully understood, it is a multifactorial disease. “Hereditary factors are present in approximately 10% of diagnosed cases of Parkinson’s disease, presenting early onset; while the other 90% of cases are categorized as idiopathic or sporadic Parkinson’s disease, occurring in older individuals and may be associated with exposure to environmental agents,” the researchers say. This disease, first described by English physician James Parkinson, M.D. in 1817, involves neurochemical changes that present as “the appearance of cardinal motor symptoms, such as bradykinesia, rigidity, postural instability, and rest tremor, which are essential for the clinical diagnosis of the disease,” the researchers note. The […]

(Beyond Pesticides, April 16, 2025) Documented for the first time, 15 currently used pesticides (CUPs) and four metabolites (breakdown or transformation products—TP) were found in the marine atmosphere over the Atlantic Ocean. Three legacy (banned) pesticides were also discovered. According to a recent study published in Environmental Pollution, researchers found empirical evidence for pesticide drift over remarkably long distances to remote environments. The findings of this study build on existing research that pollution knows no borders or boundaries, emphasizing Beyond Pesticides’ mission to advocate for the value of the precautionary principle through the elimination of synthetic chemicals and replacement with organic systems that address the root causes of pest pressures–including systemic failure to feed soil microbial life.   Background and Methodology “In this study, 329 pesticides, including 282 CUPs and 36 transformation products, were [sampled for] in the atmosphere across a south-north transect on the Atlantic Ocean,” said the authors. They unpack the three main objectives to address the focus and major objectives of their research: “[T]he determination of pesticide concentrations in the atmosphere of the Atlantic Ocean, The investigation of the spatial distribution of pesticides across the Atlantic Ocean, and The elucidation of potential sources and factors influencing pesticide transport […]

(Beyond Pesticides, April 15, 2025) A study in Communications Earth & Environment, through field, greenhouse, and laboratory experiments involving three plant bug species, finds both species-specific and sex-specific sensitivity responses to neonicotinoid insecticide exposure—highlighting the threats to grassland insect communities that are disregarded in risk assessments. By assessing the effects of Mospilan®SG, with the active ingredient acetamiprid, the researchers determine that nontarget plant bug species are highly sensitive to neonicotinoids and face community-level harm with exposure. As systemic insecticides, neonicotinoids move through the vascular system of plants, expressing the poison through pollen, nectar, and guttation droplets. As persistent pesticides, these chemicals indiscriminately poison insects and organisms in the soil. “Although pesticides have been proposed as one of the main causes of insect decline, there are still few studies assessing their effects on non-target species under field conditions,” the authors state. They continue: “In this study, we address the existing research gap on insecticide exposure of non-target herbivorous insects, focusing on two main aspects: (1) realistic exposure scenarios, (2) community-level effects, i.e., differential sensitivity between closely related species and between sexes of the same species. We chose plant bugs (Heteroptera: Miridae) as a model group because they are one of the […]

(Beyond Pesticides, April 4, 2025) In March, the California Department of Pesticide Regulation (DPR) announced the launch of SprayDays California, “a first-of-its-kind statewide system designed to provide transparent, accessible and timely notifications and information about the use of specific pesticides[,]“ according to the agency’s press release. The state says that notification will occur in “advance of the scheduled use of California restricted material pesticides in production agriculture.” Growing out of the passage of AB 617 Community Emissions Reduction Act in California, passed in 2017, farmworker safety advocates have long been urging an implementation strategy that provides notification of pesticide spraying. In late 2017, the California Air Resources Board (CARB) began implementation of AB 617, a bill enacted with the stated intent of addressing the air quality crisis in many communities of predominantly people of color who are disproportionately harmed by toxic chemicals. While the overall goal of the law is to reduce air pollution in these communities, farmworker advocates have sought to operationalize a pesticide spraying notification system to warn communities when nearby spraying is scheduled to take place. The idea behind notification programs and transparency in government is that it enables those potentially exposed to take precautionary measures to […]

(Beyond Pesticides, April 3, 2025) As highlighted by Beyond Pesticides in recent comments to the U.S. Environmental Protection Agency (EPA), chlorpyrifos (CPF) has been under scrutiny for decades due to associated adverse health effects, noted particularly in the extensive and consistent scientific evidence of neurotoxic dangers to children’s health. The latest research on CPF, published in Environmental Toxicology and Genes & Diseases, reveals additional threats to the immune system and male reproduction that are not captured in current EPA risk assessments of chlorpyrifos and raises serious health questions, given that residues are found throughout the food supply. CPF, a widely used organophosphate insecticide in agriculture, is a cholinesterase inhibitor that binds irreversibly to the active site of an essential enzyme for normal nerve impulse transmission, acetylcholine esterase (AChE), inactivating the enzyme. Many insecticides, including organophosphates and carbamates, target AChE, causing them to be highly toxic to both insects and mammals that have this enzyme as a crucial part of their nervous systems. The history of chlorpyrifos exemplifies the failure of pesticide law and policy, as this chemical, among many others, not only has direct adverse health effects but is contributing to the climate crisis, biodiversity collapse, and disproportionate levels of […]

(Beyond Pesticides, March 27, 2025) In Ecotoxicology, results of a study on Nile tilapia (Oreochromis niloticus) exposed to florpyrauxifen-benzyl (FPX) suggest the new herbicide causes oxidative stress (imbalances affecting the body’s detoxification abilities that lead to cell and tissue damage), with specific genotoxic (damage to genetic material) and hepatotoxic (damage to the liver) effects on nontarget species. The authors state: “According to the available literature, no data exist on the toxicity of FPX in fish. Therefore, this study aims to investigate, for the first time, the potential toxicity and associated mechanistic effects of the pyridine-carboxylic acid herbicide (FPX) on the non-target species, Nile tilapia.” According to the Wisconsin Department of Natural Resources, “Florpyrauxifen-benzyl is a systemic herbicide (i.e., it moves throughout the plant tissue). It is a WSSA Group 4 herbicide, meaning that the mechanism of action is by mimicking the plant growth hormone auxin and causing excessive elongation of plant cells, ultimately killing the plant.” The researchers, from Menoufia University, the Agricultural Research Center, and Cairo University in Egypt, focus on FPX as it is the active ingredient in Divixton 2.5% EC, a newly released herbicide used in rice fields and applied directly to freshwater aquatic bodies for emergent […]

(Beyond Pesticides, March 25, 2025) An editorial in Expert Review of Cardiovascular Therapy finds that triazole fungicides pose a significant risk of cardiotoxicity with “growing concerns regarding their safety for human health, especially in long-term exposure,” the authors share. After analyzing the known mechanisms of cardiotoxicity of triazole pesticides in mammals, they conclude that “the most effective approach to mitigating triazole-induced cardiotoxicity lies in prevention.”  Triazoles, a class of fungicides, target fungi by inhibiting the biosynthesis of ergosterol, an essential component of their cell membranes. As the researchers share, “Compounds such as tebuconazole, propiconazole, and difenoconazole are among the most used triazoles in agriculture.” Triazoles are utilized as antifungal medications, despite the rise of resistant infections, in addition to their use as systemic pesticides on many fruit and vegetable crops, including grapes, wheat, corn, and soybeans.   As Beyond Pesticides’ previous coverage indicates, many triazole fungicides in the U.S. are registered for use despite evidence of endocrine disruption established over a decade ago in a U.S. Geological Survey report. These pesticides exhibit common mechanisms of toxicity often disregarded in U.S. Environmental Protection Agency (EPA) risk assessments, with a multitude of studies showcasing the myriads of health threats that the agency does […]