05
Sep
Reinforcing Scientific Findings, Insecticide Permethrin Found To Alter Gut Microbiome, Causing Obesity
(Beyond Pesticides, September 5, 2025) A study in Journal of Agricultural and Food Chemistry finds permethrin, a commonly used synthetic pyrethroid insecticide, to be disruptive to the gut microbiome, altering microbiota and leading to increased formation of fat cells (adipogenesis) and metabolic disorders. With an aim to “comprehensively elucidate the effects of permethrin on gut microbiota, lipogenesis, and the associated molecular mechanisms,†the study explores the adverse effects of permethrin exposure in adult mice through multiple experiments. “Our study provides the first in vivo [in a living organism] evidence suggesting a potentially causal relationship between permethrin exposure and the development of obesity, potentially mediated by specific gut microbiota-derived metabolites,†the researchers explain. They continue, “Notably, this work is the first to define a distinct microbiota−metabolite−host axis as a critical mediator of environmental toxicant-induced metabolic dysfunction.†Permethrin is widely used as an insecticide on crops, such as cotton, corn, and wheat, as well as on livestock, in indoor and outdoor areas, and for treating lice and scabies. Mosquito abatement programs often utilize permethrin, further adding to the various exposure routes of this neurotoxic chemical. (See additional uses and health effects of permethrin in Beyond Pesticides’ Gateway on Pesticide Hazards and Safe […]
