17
Jul
(Beyond Pesticides, July 17, 2026) It is now well established that frequent exchange of signaling between the brain and the gut is a crucial feature of human mental and physical health. External chemicals introduced through the digestive system affect the gut microbiome, which in turn influences the brain. Perhaps the most ubiquitous and pernicious bad actor in the large cast of pesticides shown to disrupt the gut-brain axis is the weed killer glyphosate. A team from the University of Cork in Ireland has published an innovative study whose results, while subtle, reaffirm that pesticides, and glyphosate in particular, affect behaviors in mice that are important for social relations, learning, and reproduction. Numerous pesticides disrupting the gut-brain axis are implicated in immune disorders, neurodegenerative diseases, diabetes, autism spectrum disorder, and many other diseases. See Beyond Pesticides’ Gut-Brain-Axis Archives for more detail. Because of the mounting awareness of the gut-brain axis, a renewed focus in psychiatry on the behavioral consequences of exposure to environmental chemicals is emerging. The study, published in the June 16 issue of Molecular Psychiatry, finds that the accepted reference dose of glyphosate affects male mice, increasing anxiety and altering social interactions, while female mice mostly move around less than […]
Posted in Brain Effects, Microbiome, Uncategorized | No Comments »
11
Jun
(Beyond Pesticides, June 11, 2025) Researchers developed a novel tool* in a recent study published in Nature Communications this year that successfully creates a map of the “pesticide-gut microbiota-metabolite network,” identifying “significant alterations in gut bacteria metabolism.” While the study authors acknowledge that this is not a complete map, since they selected specific pesticides and bacterial partners, the research adds to the body of peer-reviewed scientific literature that underscores the relationship between pesticide residues and human gut health. Organic farmers, as well as any land steward invested in agroecological practices and soil health, understand that microbial life (both in the body and in the soil) is dangerously undermined by the status quo of chemical-intensive land management. Background and Methodology The researchers leverage mass spectrometry to test metabolite (metabolomics) and lipid (lipidomics) relationships with pesticide residues, as well as an in vivo mouse model. *The map itself is a form of computational biology, which advocates have warned could be a false solution if not accompanied by other proven scientific methods. See here for analysis by the Natural Resources Defense Council on risks of unproven methods such as New Approach Methodologies [NAMs]. All major phylogenetic (“evolutionary relationships among biological entities”) groups are […]
Posted in Chlorpyrifos, cypermethrin, DDT, Diazinon, Dichlorvos, Endosulfan, Glyphosate, Malathion, Metabolites, methoxychlor, Microbiata, Microbiome, Parathion, Permethrin, Uncategorized | No Comments »
06
Dec
(Beyond Pesticides, December 6, 2024) On December 2, the U.S. Environmental Protection Agency (EPA) announced yet another milestone in the convoluted life span of the insecticide chlorpyrifos. Under the deceptive headline “EPA Proposes Rule to Revoke Most Food Uses of the Insecticide Chlorpyrifos,” EPA stated that it is improving environmental protection by revoking all usages of chlorpyrifos except for 11 food and feed crops. The proposal was deemed “unconscionable” by Beyond Pesticides executive director Jay Feldman in an article in The New Lede. EPA claims this plan would reduce annual chlorpyrifos application by 70% compared to “historical usage.” Chlorpyrifos is a known neurological and reproductive toxicant. EPA has been cutting back on approved uses for years but is far behind other environmental authorities—the European Food Safety Authority and Thailand have banned it altogether, and California has banned its agricultural use. The trouble with EPA’s latest attempt is that it does nothing to clarify and rationalize EPA’s process, and it will not protect the public, because those 11 remaining products are among the most extensively grown and used in the world: soybeans, sugar beets, cotton, wheat, apples, citrus fruits, strawberries, alfalfa, cherries, peaches, and asparagus. Chlorpyrifos is an organophosphate chemical. These […]
Posted in Agriculture, Chlorpyrifos, Environmental Protection Agency (EPA), Nervous System Effects, Uncategorized | 1 Comment »
15
Aug
(Beyond Pesticides, August 15, 2024) Adding to research that has linked insecticide disruption of the gut microbial community to the progression of Parkinson’s Disease (PD) in the brain is a recently published study that further examines the gut-brain mechanism at work. A review by neuroscientist Nabanita Ghosh, PhD in Chemical Research in Toxicology—coauthored by Krishnendu Sinha, PhD, molecular toxicologist and applied pharmacologist, and molecular toxicologist Parames C. Sil, PhD—focuses on how pesticide-induced microbial community alterations specifically drive the initiation of PD and the precise mechanism. The study also explores microbiota changes at different stages of PD progression, offering recent findings.    The researchers derive their data from the examination of PD patients, evaluating the “interaction between pesticides and gut bacteria in PD patients, summarizing how pesticides cause imbalances in gut bacteria, the resulting changes, and their overall effects on the PD prognosis.”  The review “looks at how pesticides and gut bacteria separately influence PD development and progression, highlighting the harmful effects of pesticides and changes in gut bacteria.” The team concludes that pesticide exposure is connected to PD onset through “disturbances in gut function and alterations in intestinal microbiota.” However, the “exact role of microbial factors in this connection remains […]
Posted in Brain Effects, Gut Dysbiosis, Microbiata, Microbiome, Paraquat, Parkinson's, Uncategorized | 1 Comment »
