12
Jul
Western Australian Researchers Mine Antimalarial Compounds as Potential Herbicides
(Beyond Pesticides, July 12, 2017) In a move that threatens to further the spread of antibiotic resistance, researchers at the University of Western Australia (UWA) mining a collection of antimalarial drugs for potential new herbicides. Joshua Mylne, PhD, a senior lecturer in the School of Molecular Sciences (SMS) who directs the project, got started based on work he did while in the Australian Army Reserve. There he discovered that “malarial parasites are actually closely related to plants.” Due to widespread resistance of weeds to the popular herbicide glyphosate, Dr. Mylne began investigating antimalarial drugs as potential replacements. Malaria parasites are actually protozoans in the genus Plasmodium. Their crucial connection with plants is that the parasite contains a plastid similar to the chloroplast in plants. Like the chloroplast in plants, this plastid is critical for the survival of the parasite. Along with organic chemist Keith Stubbs, PhD, associate professor in SMS, Dr. Mylne began screening chemicals in the “Malaria Box,” an open source collection of potential anti-malarial drugs that have never been commercialized. Of the 20 chemicals tested on the small weed Arabidopsis thaliana, 11 were found to have some herbicidal activity. They were then compared to the herbicides glyphosate, glufosinate, asulam, […]
