(Beyond Pesticides, November 19, 2024) Researchers at Stanford University recently published a study in Cancer, an international interdisciplinary journal of the American Cancer Society (ACS), that reveals a correlation for numerous pesticides with increased prostate cancer occurrence and associated death. The study finds that exposure to 22 pesticides is positively associated with prostate cancer. The 22 pesticides include 2,4‐D, acephate, azoxystrobin, bifenthrin, carbaryl, chloropicrin, cloransulam‐methyl, cyhalothrin‐lambda, diflufenzopyr, diuron, glyphosate, hexazinone, linuron, methyl parathion, pendimethalin, propiconazole, sulfosate, thiamethoxam, thifensulfuron, tribenuron methyl, trifloxystrobin, and trifluralin. (See more on 2,4-D and cancer prevalence here and here.) As prostate cancer is a leading national health concern, the authors investigate agricultural pesticide exposure and compared it to prostate cancer incidence and mortality across counties in the contiguous U.S. “The geographic variation in prostate cancer incidence and mortality suggests that regional environmental factors, such as pesticide exposure, may contribute to the development of prostate cancer,” the researchers postulate. In comparing county‐level associations of 295 pesticides and prostate cancer reports, the authors were able to conduct an environment‐wide association study (EWAS) to determine any statistically significant links. “We acquired annual estimated total usage data (kg per county) for all pesticides reported and applied to agricultural crops grown […]

(Beyond Pesticides, August 14, 2024) Pesticide exposure is linked to negative birth outcomes in a recent study in the American Journal of Epidemiology. This study adds to that body of science, but is novel research since, “Epidemiological studies of pesticide exposures and stillbirth in the United States have not been published in the past two decades, a time period that has seen dramatic changes in pesticide use compared to the 20th century,” the authors state. The study analyzes Arizona pesticide use records and birth certificates from 2006-2020. Researchers correlate mothers living within 500 meters of any pyrethroid, organophosphate (OP), or carbamate insecticide applications during specific windows before and during pregnancy with stillbirth. The authors focus on exposure during the prenatal period, as it is a susceptible time frame in which any contact with pesticides can negatively impact health. Numerous studies report several adverse birth and childhood outcomes with prenatal exposure. To link pesticide exposure and negative birth outcomes, Arizona records that encompass 1,237,750 births, 2,290 stillbirths, and 27 pesticides were analyzed. The authors “evaluate associations of pyrethroids, OPs, and carbamate insecticides with stillbirth by using data from the Arizona Pregnant women’s Environment and Reproductive outcomes Study (Az-PEARS), a project that […]

(Beyond Pesticides, July 8, 2024) Please submit comments by Wednesday, July 31, 2024. Acephate, an insecticide and member of the highly toxic organophosphate (OP) family, is so toxic that EPA is proposing to ban all uses except the systemic injection into trees. A comment period is open, and EPA is accepting comments through Wednesday, July 31, after extending the earlier July deadline. With this remaining use, EPA is still not recognizing that systemic neonicotinoid pesticides can cause serious environmental harm to the ecosystem through indiscriminate poisoning of organisms. >> Submit a comment on acephate and tell EPA that no pesticide should be allowed to be used if the crop can be produced organically.  EPA proposes to cancel all uses of acephate other than tree injection to eliminate all risks of concern it has identified that exceed its level of concern for dietary/drinking water risk, residential and occupational risks, and risks to non-target organisms. As Beyond Pesticides points out, although the tree injection method does not pose excessive dietary or aggregate health risk and does not pose any untoward occupational or post-application human health risks of concern, there are significant ecological risks posed that the agency has neglected. Rather than assessing the ecological risks of tree […]

(Beyond Pesticides, May 8, 2024) In an unexpected turnaround, the U.S. Environmental Protection Agency (EPA) announced at the end of April a Proposed Interim Decision (PID) to discontinue all but one application of the insecticide acephate. Acephate is an organophosphate pesticide, a well-known neurotoxicant, widely banned globally, including in the European Union. Under the proposal, all uses would end except for the injection of trees that do not produce fruit or nuts. In its proposed action, EPA asks the manufacturer to offer the agency a voluntary settlement, a process that typically compromises the health of the public, workers, and the environment. Acephate, an organophosphate (OP) pesticide, is approved for use in both agricultural settings, including crops like cotton and soybeans, and nonagricultural applications, such as injections for forestry trees. Acephate affects the nervous system by inhibiting the acetylcholinesterase (AChE) enzyme. Importantly, chronic, low levels of exposure can cause a range of adverse human health outcomes, from cancer to birth defects, reproductive and developmental problems, and learning disabilities. While the proposed April interim decision, if it comes to pass, is welcomed by advocates, some are concerned that EPA’s proposal does not fully critique the scientific documents and conclusions on risk that […]

(Beyond Pesticides, May 1, 2024) According to a new analysis by Consumer Reports, the U.S. Department of Agriculture (USDA) Pesticide Data Program (PDP) Annual Summary has once again failed to accurately portray the safety of some of the most commonly sold fruits and vegetables in the United States. A review of seven years of PDP data show that 20% of the foods tested pose a “high risk” to the public and 12 specific commodities are so dangerous that children or pregnant people should not eat more than one serving per day, according to Consumer Reports analysis. Consumer Reports contend that U.S. Environmental Protection (EPA) pesticide residue tolerances are too lenient. To better evaluate potential health risks associated with various foods, Consumer Reports applied stricter residue limits than the EPA tolerances (see here for CR’s analytical methodology). Notably, USDA certified organic food products are not permitted to be produced with the pesticides identified by the report. Pesticide residues found in organic, with rare exception, are a function of the off-target chemical-intensive agriculture pollution through pesticide drift, water contamination, or background soil residues. The Consumer Reports results fly in the face of the rosy outlook reported by the USDA in its 2022 […]

(Beyond Pesticides, February 1, 2024) A study published in Science of The Total Environment finds an insecticide ban would be economically beneficial in preventing Parkinson’s disease (PD). Despite differing pesticide exposure scenarios, PD risk lowers without pesticide exposure, especially insecticides that elicit neurotoxicity. In fact, a study published in 2023 notes high exposure to household pesticides, which are primarily insecticides, increases the risk of developing Parkinson’s disease (PD) two-fold. There is a multitude of epidemiologic research on Parkinson’s disease demonstrating several risk factors, including specific genetic mutations and external/environmental triggers (e.g., pesticide use, pollutant exposure, etc.). However, several studies find exposure to chemical toxicants, like pesticides, has neurotoxic effects or exacerbates preexisting chemical damage to the nervous system. Studies suggest neurological damage from oxidative stress, cell dysfunction, and synapse impairment, among others, can increase the incidence of PD following pesticide exposure. Despite the widespread commercialized use of household pesticides among the general population, few epidemiologic studies examine the influence household pesticides, mainly insecticides or disinfectants, have on the risk of PD. Additionally, many studies demonstrate the association between PD onset and occupational (work-related) pesticide exposure patterns. Parkinson’s disease is the second most common neurodegenerative disease, with at least one million Americans […]

(Beyond Pesticides, September 29, 2022) A study published in the International Journal of Hygiene and Environmental Health finds an association between retinoblastoma risk and prenatal exposure to pesticides. Retinoblastoma is a rare eye cancer, with over 200,000 cases in the U.S., most of which are children under the age of five. Despite occurring among offspring, this cancer is often not hereditary. Instead, a mutation in the RB1 gene during early development in the womb destabilizes and augments cell growth. Although the etiology or cause of childhood eye cancer involves the interaction of multiple components like lifestyle and genetics, emerging evidence indicates that environmental contaminants like pesticides (e.g., occupational exposures, air pollution, pesticides, solvents, diet, etc.) play a role in disease etiology. Pesticide contamination is widespread in all ecosystems, and chemical compounds can accumulate in human tissues resulting in chronic health effects. Children are particularly vulnerable to the impacts of pesticide exposure as their developing bodies cannot adequately combat exposure effects. Already, studies find low levels of pesticide exposure during pregnancy or childhood cause adverse health effects from metabolic disorders to mental and physical disabilities. While medical advancements in disease survival are more prominent nowadays, childhood cancer remains the leading cause of death from disease among children. […]

(Beyond Pesticides, August 25, 2022) A study published in World Journal of Pediatrics finds an association between antibiotic and neonicotinoid (neonic) exposure and onset of pediatric (childhood) type 1 diabetes (T1D) through effects on the gut microbiome. Individuals with type 1 diabetes are at higher risk of other autoimmune disorders, including thyroid and celiac disease. Ample evidence demonstrates environmental contaminants like pesticides and antibiotics negatively affect human mouth and gut microbes. Through the gut biome, pesticide exposure can enhance or exacerbate the adverse effects of additional environmental toxicants on the body. Moreover, studies find low levels of pesticide exposure during pregnancy or childhood cause adverse health effects from metabolic/immune disorders to mental and physical disabilities. Children are particularly vulnerable to the impacts of pesticide exposure as their developing bodies cannot adequately combat exposure effects. Although studies show how chemical exposures affect overall human health, more research is now questioning how these toxic chemicals influence gut health and subsequent occurrence of diseases. In children, gut microbiome disruption, or gut dysbiosis, has significant associations with type 1 diabetes development, and disruption of gut microbiota plays a role in type 2 diabetes development. Over 11 percent (>37 million) of individuals in the U.S. have diabetes, and cases are growing by millions annually. With increasing rates of type 1 and […]

(Beyond Pesticides, June 4, 2021) The release of the most recent U.S. Geological Services (USGS) study of pesticide contamination of rivers on the U.S. mainland finds that degradation of those rivers from pesticide pollution continues unabated. USGS scientists looked at data from 2013 to 2017 (inclusive) from rivers across the country and offered these top-level conclusions: “(1) pesticides persist in environments beyond the site of application and expected period of use, and (2) the potential toxicity of pesticides to aquatic life is pervasive in surface waters.” Beyond Pesticides maintains that ultimately, water quality and aquatic organisms and their ecosystems will be fully protected from pesticides through a wholesale movement to organic land management practices. USGS undertakes periodic assessments of the presence and toxicity of pesticides in the country’s surface waters under the agency’s National Water-Quality Assessment Program. Recent news from these studies has not been good. In September 2020, Beyond Pesticides reported on another, related USGS survey, which found that nearly 90% of U.S. rivers and streams are contaminated with mixtures of at least five or more different pesticides. A March 2021 Beyond Pesticides Daily News article noted that USGS research demonstrated that, of 422 water samples taken from streams across […]

(Beyond Pesticides, October 14, 2020) Exposure to certain endocrine disrupting pesticides increases the risk men, and Hispanic men in particular, will contract testicular cancer, according to research presented at the American Association for Cancer Research Conference on the Science of Cancer Health Disparities in Racial/Ethnic Minorities and the Medically Underserved. The data show that living near the use of the insecticide acephate presents the greatest cancer risk. “Testicular cancer rates have been rising for decades and are rising especially quickly among Hispanics in the United States,” said Scott Swartz, an MD candidate in University of California Berkeley-UCSF Joint Medical Program, to Healio. “Given that Hispanics are disproportionately exposed to many endocrine-disrupting pesticides in California, we were interested in investigating the potential effects of nearby endocrine-disrupting pesticide application on testicular cancer among Hispanics in California.” Using public health databases, researchers assessed a group of 381 men diagnosed with testicular cancer while 15 to 19 years old, during the years 1997-2011. This cohort was compared to a control group of 762 otherwise healthy men of similar age, race and ethnicity during the same time. California’s Pesticide Use Report system was used to analyze agricultural pesticide applications within 1.8 miles of a study […]

(Beyond Pesticides, August 5, 2010) A 400-year old large old grape vine considered to be the nation’s oldest in Manteo, North Carolina and known lovingly as “Mother Vine,” is slowly recovering from a powerful dose of herbicide sprayed by a utility company. The Virginia-based Dominion Power Company contracted Lewis Tree Service to spray power poles along the roads in the Manteo in May. The herbicide they used, Garlon3A, was accidentally sprayed on a tiny shoot from the vine that had grown a few feet up a pole on 84-year old Jack Wilson’s property. Unaware of the recent herbicide spraying by the utility power company, he noticed various brown, dead sections that began to appear in the plant in May. Not only did the vine suffer, but about 10 feet of a nearby hedge died, along with three limbs of a large pecan tree that had to be trimmed. The active ingredient in Garlon 3A, a Dow Chemical product, is triclopyr. It is a systemic herbicide which means that the poison spreads from the ends of the vine back toward the root. As a broadleaf weed killer, triclopyr is frequently used along rights-of-way and on industrial sites. In laboratory tests, triclopyr […]

(Beyond Pesticides, August 3, 2010) A new study shows that due to a flaw in standard risk assessments, which consider toxic effects at fixed exposure times, the risks posed by the neonicotinoid pesticides imidacloprid and thiacloprid are likely to be underestimated. The authors believe that minute quantities of imidicloprid may be playing a much larger role in killing bees over extended periods of time than previously thought. The study, “The significance of the Druckrey—Küpfmüller equation for risk assessment””The toxicity of neonicotinoid insecticides to arthropods is reinforced by exposure time,” was published online July 23, 2010 in the journal Toxicology. The authors believe that standard risk assessment calculations underestimate toxicity because they do not accurately account for the interplay of time and level of exposure. According the study: The essence of the Druckrey—Küpfmüller equation states that the total dose required to produce the same effect decreases with decreasing exposure levels, even though the exposure times required to produce the same effect increase with decreasing exposure levels. Druckrey and Küpfmüller inferred that if both receptor binding and the effect are irreversible, exposure time would reinforce the effect. The Druckrey—Küpfmüller equation explains why toxicity may occur after prolonged exposure to very low toxicant […]

(Beyond Pesticides, March 13, 2008) Exposure to certain chemicals, including pesticides and nerve agents, explains the high rates of illness in Persian Gulf War Veterans, according to a new study published in the Proceedings of the National Academy of Sciences. Veterans from the 1990-91 conflict have a higher rate of chronic, multi-symptom health problems than either non-deployed personnel or those deployed elsewhere. Symptoms routinely reported by these veterans include fatigue, muscle or joint pain, memory problems, trouble sleeping, rash and breathing problems. Due to the findings, the study author, Beatrice Golomb, M.D., Ph.D., associate professor of medicine at the University of California, San Diego School of Medicine, warns of the potential risk to civilians exposed to pesticides.“Health issues among Gulf War veterans have been a concern for nearly two decades. Now, enough studies have been conducted, and results shared, to be able to say with considerable confidence that there is a link between chemical exposure and chronic, multi-symptom health problems,” said Dr. Golomb. “Furthermore, the same chemicals affecting Gulf War veterans may be involved in similar cases of unexplained, multi-symptom health problems in the general population.”The study synthesized evidence regarding a class of chemicals known as acetylcholinesterase inhibitors (AchEs), including […]