(Beyond Pesticides, August 21, 2024) A literature review, published this month in the Journal of Agricultural and Food Chemistry, explores levels of pesticide residues found in samples of human urine with environmental exposure and dietary intake and confirms prior findings about the benefits of an organic diet. Similar to past findings, lower concentrations of chemicals are detected in the urine of participants who report eating an organic diet. By analyzing 72 scientific research studies published between 2001 to 2023, the review assesses routes of exposure and “explores urinary concentrations and detection frequency of metabolites of organophosphates and pyrethroids, as well as herbicides such as 2,4-D and glyphosate,” the authors say. While “exposure to pesticide residues is influenced by a variety of demographic factors, including occupation, agricultural practices, seasonal variations, residence, diet, age, and gender,” the authors say, the concentrations of pesticides and their metabolites in human urine highlights the disproportionate risk to certain groups as well as the overall threat to the health of humans and the environment. Pesticide exposure can occur from dermal/skin contact or inhalation, through residence or work, and with dietary intake. “Pesticides in urine can be detected as parent compounds, specific metabolites corresponding to a specific […]

(Beyond Pesticides, August 14, 2024) Pesticide exposure is linked to negative birth outcomes in a recent study in the American Journal of Epidemiology. This study adds to that body of science, but is novel research since, “Epidemiological studies of pesticide exposures and stillbirth in the United States have not been published in the past two decades, a time period that has seen dramatic changes in pesticide use compared to the 20th century,” the authors state. The study analyzes Arizona pesticide use records and birth certificates from 2006-2020. Researchers correlate mothers living within 500 meters of any pyrethroid, organophosphate (OP), or carbamate insecticide applications during specific windows before and during pregnancy with stillbirth. The authors focus on exposure during the prenatal period, as it is a susceptible time frame in which any contact with pesticides can negatively impact health. Numerous studies report several adverse birth and childhood outcomes with prenatal exposure. To link pesticide exposure and negative birth outcomes, Arizona records that encompass 1,237,750 births, 2,290 stillbirths, and 27 pesticides were analyzed. The authors “evaluate associations of pyrethroids, OPs, and carbamate insecticides with stillbirth by using data from the Arizona Pregnant women’s Environment and Reproductive outcomes Study (Az-PEARS), a project that […]

(Beyond Pesticides, January 26, 2024) In addition to maternal (mothers) exposure, children experience exposure to pyrethroid insecticides earlier in life as levels significantly increase post-natal (after birth), according to a study published in Frontiers in Public Health. This study is one of the few studies to investigate pyrethroid exposure concentrations in the urine of newborns and children within their first year of life. However, this research reiterates what many other studies demonstrate on pyrethroids’ impacts on children’s health, primarily due to their notorious neurotoxic properties. The findings indicate that exposure to pyrethroids during pregnancy and early childhood exposure has links to adverse health effects, including neurodevelopmental delays (e.g., autism), behavioral issues (e.g., attention deficit [hyperactivity] disorder), and endocrine disruption (e.g., delay in puberty). Pesticide exposure during pregnancy is of specific concern as health effects for all life stages can be long-lasting. Just as nutrients are transferable between mother and fetus, so are chemical contaminants. Studies find pesticide compounds in the mother’s blood can transfer to the fetus via the umbilical cord. Therefore, pesticide exposure during pregnancy affects both the mother and child’s health. Beyond Pesticides has covered a variety of pregnancy risks from pesticides and other toxic chemicals, including these in just […]

(Beyond Pesticides, August 30, 2023) Invasive yellow-legged hornets have been spotted near Savannah, Georgia, causing concern among agriculture officials. These hornets are known for their ability to prey on honeybees and other pollinators, and their presence in the United States is a cause for alarm. This is the first time a live specimen of this species has been detected in the open United States, according to the Georgia Department of Agriculture. The hornets, which are native to Southeast Asia, have been spotted in other parts of the world, including Europe, where they have caused significant damage to bee populations. They are considered “invasive,” which means the hornet is not native and officials expect their introduction to result in economic, environmental, or health-related damage to humans, animals, plants, or the environment. In response to the sighting in Georgia, officials are taking action to eradicate the hornets before they can cause any harm to US agriculture. One of the methods being used to eradicate the hornets is the localized use of the highly toxic insecticide cypermethrin on nests. The pesticide has been registered for use in agriculture and residential pest control since the 1970s. It kills insects such as mosquitoes, flies, ticks, […]

(Beyond Pesticides, February 22, 2023) Combining neonicotinoid insecticides with other commonly used pesticides can result in synergistic effects on honey bees, increasing toxicity more than any individual chemical could, according to research published in Scientific Reports earlier this month. The data highlight the grave inadequacy of the U.S. Environmental Protection Agency’s (EPA) process for evaluating pesticide risks. Under current regulations, EPA requires chemical manufacturers to submit data only on singular active ingredients. Yet, pesticide products may be packaged or ‘tank mixed’ with other, equally toxic pesticides without any obligation to determine the toxicity of the material that is actually being applied. Independent research is left to fill in these gaps, and the data increasingly shows that toxicity with pesticide mixtures amounts to a roll of the dice: sometimes combinations are less toxic, sometimes their toxicities are merely additive. But more often than not, pesticide mixtures result in synergistic effects that make the product significantly more toxic than either individual chemical alone. To understand how pesticide combinations are harming pollinators, scientists began with baseline data on the individual toxicity range  that common pesticides pose to honey bee colonies. Research was conducted on honey bees reared in the Stoneville Wildlife Management Area […]

(Beyond Pesticides, September 1, 2022) Low level exposure to synthetic pyrethroid insecticides at 6-8 months of age is associated with language development delays in two-year old toddlers, according to research published in Neurotoxicology this month. This is the latest study to link this class of chemicals to developmental delays in young children. Despite a steady drum of concerning research, the U.S. Environmental Protection Agency (EPA) in 2019 removed a crucial “safety factor” intended to protect children’s health from synthetic pyrethroids, allowing higher levels of the insecticides to be sprayed on food, in homes, and playing fields around the country.   To investigate the impact of synthetic pyrethroids on language development, scientists enrolled 327 expectant mothers in their third trimester. The mothers, all from rural areas of China, were selected if they had no history of significant pesticide exposure or family history of serious disease. Urine samples were taken from the women during pregnancy, and from infants 6-8 months after birth. Scientists analyzed samples for concentrations of three different synthetic pyrethroid breakdown products (metabolites), including 3-phenoxybenzoic acid (3PBA), 4-fluoro-3-phenoxybenzoic acid (4F3PBA), and cis-2,2dibromovinyl-2,2-dimethylcyclopropane-1-carboxylic acid (DBCA). While 3PBA is a metabolite of many synthetic pyrethroids, 4F3PBA a more specific metabolite of cypermethrin, […]

(Beyond Pesticides, September 10, 2021) Research conducted in Thailand shows that exposures to pesticides, even at low levels, can impact the human endocrine system and distort thyroid function. The study looked specifically at interactions of genetics and environment: it investigated associations between variations in genes involved in pesticide metabolism and altered thyroid hormone concentrations in agricultural workers. This research underscores some of the complexity and difficulty of determining human vulnerability to impacts of pesticide exposures, given genetic variables. Beyond Pesticides believes that this very complexity is a cogent argument for anchoring regulation of pesticides in the Precautionary Principle. If exposure to a pesticide can cause damage to human (or environmental) health, it sometimes will do so. Thus, to protect people’s health, agriculture and other land management practices must transition from the use of synthetic pesticides to broad adoption of organic regenerative approaches that obviate the need for such chemicals. This research is part of a longitudinal study that seeks to evaluate sub-chronic impacts, on thyroid hormone levels, of repeated exposures to a variety of pesticides. The farmworkers studied in this phase comprise two groups: those working on organically managed farms (216 subjects), and those working on conventional farms that use pesticides […]

(Beyond Pesticides, September 10, 2020) A new analysis by Science of Cannabis Laboratories Inc. (SC Labs) finds detectable concentrations of pesticides and heavy metals in rolling papers, with hemp/blunt wraps and cellulose-based rolling papers containing the highest levels of contaminants. The analysis follows a SC Labs’ finding of high levels of chlorpyrifos—a neurotoxic, organophosphate insecticide—in the rolling paper of pre-rolled cannabis, which was undergoing compliance testing. Although the rolling paper regulations generally track standards for toxic tobacco products (which means there is very little meaningful regulation), the rolling paper use with cannabis may add an addition layer of scrutiny since some statewide cannabis regulations and independent certifications adhere to stricter guidelines similar to organic practices. Researchers note the goals of the experiment “were to assess the exposure risks to the consumer as well as identify any potential liabilities for cannabis producers who use these products to make their pre-roll products.” This report, and others like it, are significant as cannabis use expands in in the U.S. and around the world, and given that one of the most popular ways to consume cannabis product is as a rolled cigarette. Study author and president of SC Labs Josh Wurzer, Ph.D., said, “This [issue] is something that cannabis and paper […]

(Beyond Pesticides, July 9, 2020) Conventional U.S. milk contains growth hormones, antibiotics, and low to elevated levels of pesticides not found in organic milk, according to a study published in the journal of Public Health Nutrition by Emory University researchers. Milk can bioaccumulate certain organic pollutants, making it a valuable medium to assess what chemical we might be ingesting daily. With milk being one of the most consumed beverages in the U.S., in addition to its use in other popular drinks (i.e., coffee and tea), this study discloses widespread contamination and highlights the need for improved regulation. Researchers in the study note, “To our knowledge, the present study is the first study to compare levels of pesticide in the U.S. milk supply by production method (conventional vs. organic). It is also the first in a decade to measure antibiotic and hormone levels and compare them by milk production type.”  The market for conventional milk, produced in chemical-intensive agriculture, is declining, but the demand for organic milk is increasing due to concerns over chemical contamination in consumer products from pesticides and other toxic chemicals. Although the U.S. Environmental Protection Agency (EPA) sets limits for pesticide residues in food products, the agency […]

(Beyond Pesticides, May 16, 2018) Northern Harvest Sea Farms, an ocean-based fish farm in New Brunswick, Canada, was appeared in court yesterday to answer legal charges stemming from the off-label use of an unnamed pesticide added to its operations to combat severe sea lice outbreaks. The company holds nine licenses for farmed Atlantic salmon cages on the Bay of Fundy, as well as for fish farms off the Newfoundland coast. Sea lice outbreaks are a common at over-crowded, ocean-based fish farms because such facilities afford the optimum conditions for rapidly reproducing and spreading lice. In response, some companies have turned to using illegal and off-label pesticide applications to stave off the problem, which causes huge farmed salmon kills. The company was issued a $12,000 fine that was challenged as inadequate by the Grand Manan Fishermen’s Association. Bonnie Morse, project manager for the association told Canadian Broadcasting Corporation (CBC) news, “I think any time there’s a fine that’s a deterrent to illegal activity, it should be an actual deterrent to the activity,” said Morse. “When you’re looking at $1.5 million worth of fish, their actions speak for themselves.” Maria Recchia, the executive director of the Fundy North Fishermen’s Association, questioned the allowance of fish […]

(Beyond Pesticides, July 7, 2017) The active ingredients in commonly used bug sprays such as RAID leave significant residues that persist for over a year in the home, according to a study published by Brazilian researchers in the journal Environmental Toxicology and Chemistry. The pesticides tested, synthetic pyrethroids, have been linked to a range of health effects, most notably in children. The results of this study add to calls for homeowners to rethink a chemical-based approach to home pest control, in favor of simple, non-toxic practices. In the recent study, researchers compared the breakdown time of two synthetic pyrethroids, cypermethrin and beta-cyfluthrin, between laboratory conditions and those in an average home. Under lab conditions, with temperature controlled and without sunlight or ventilation, both active ingredients broke down little within the 112 day test period observed. However, the test house, where insecticides were applied according to indoor label conditions, displayed breakdown times similar to the lab results during the first 112 days. Researchers continued their observation of pyrethroids in the home for up to a year, finding after that period 44% of beta-cyfluthrin and 70% cypermethrin remained in household dust samples from the singular, original application. A 2014 study published by […]

(Beyond Pesticides, April 4, 2017) Exposure to commonly used pyrethroid insecticides results in the early onset of puberty in boys, according to a study presented at the 99th meeting of the Endocrine Society in Orlando, Florida this week. Pyrethroids, which exhibit endocrine disrupting properties, have the ability to interfere with the proper regulation of the human body’s hormonal system. This research is the first to investigate not only the association between pyrethroids and accelerated puberty, but also the causal mechanisms involved in the physiological changes taking place within the human body. For the study, Jing Liu, PhD, and colleagues from Zhejuang University in China, analyzed the urine in 463 Chinese boys aged 9 to 16 for the presence of metabolites from the pyrethroid insecticide cypermethrin. Results show that a 10% increase in the metabolite 3-PBA is associated with a roughly 4% increase in luteinizing and follicle-stimulating hormones, which facilitate puberty and sperm production. The author’s note that, “Boys with increased urinary levels of 3-PBA have a significantly increased risk of earlier pubertal onset, in which the odds of being in an advanced pubertal stage are increase by 73% to 110%.” The study, acknowledging the limitation in determining causality, further investigates the […]

(Beyond Pesticides, March 7, 2017) Another study, published by a team of French scientists in the journal Occupational and Environmental Medicine, links childhood behavioral problems to pyrethroid insecticide exposure. Synthetic pyrethroids are a class of insecticides that have increased in use over the past decade due to assumptions that they pose fewer risks to human health than older pesticide chemistries, such as organophosphates. However, this latest study is part of a growing body of research showing that pyrethroids share similar neurocognitive health concerns as these older pesticides. .   In this research, scientists investigate the interplay between pyrethroid exposure and behavioral problems through a longitudinal cohort study, which tracks levels of pyrethroid metabolites, or breakdown products, in the urine of mothers beginning between six and 19 gestational weeks and then in their children up through six years of age. Children’s behavior is measured through a screening questionnaire known as the Strengths and Difficulties Questionnaire (SDQ). SDQ measures how social a child is (altruism), whether the child has difficulty sharing problems or asking for help (internalizing disorders), as well as how defiant or disruptive a child is (externalizing disorders). The study controlled for a number of confounding factors, such as weight, education, location (rural or […]

 (Beyond Pesticides, January 20, 2016) Aldi Süd, the German supermarket chain with stores in the U.S., has become the first major European retailer to ban pesticides toxic to bees, including the neonicotinoids imidacloprid, clothianidin and thiamethoxam, from fruits and vegetables produced for their stores. Aldi has requested suppliers comply at the earliest possible time. In light of the growing pollinator crisis and due to public pressure, retailers in Europe and the U.S. are slowly beginning to make the switch away from bee-toxic pesticides. Beginning January 1, suppliers of fruits and vegetables to Aldi suppliers will have to ensure that their cultivation practices do not include the following eight pesticides identified as toxic to bees (thiamethoxam, chlorpyrifos,  clothianidin, cypermethrin, deltamethrin, fipronil, imidacloprid and sulfoxaflor) to meet  the new requirement. According to a press release from Greenpeace, the chemicals are used on various commodities in Europe  —thiamethoxam (used in lettuce and endive), chlorpyrifos, clothianidin (used in kohlrabi, herbs, Brussels sprouts, head cabbage, cauliflower and kale), cypermethrin (leek, head cabbage and leguminous vegetables), deltamethrin (cauliflower, peppers, eggplant, zucchini, cucumber, pea, head cabbage, tomato and lettuce),  imidacloprid (applied to apples, peaches, apricots and lettuce). Sulfoxaflor was recently granted regulatory approval in Europe, despite calls […]

(Beyond Pesticides, February 20, 2015) A broad-based coalition is urging Canada’s Prime Minister Stephen Harper to put a stop to proposed changes to federal aquaculture regulations, citing damage to the environment and existing businesses. The proposed amendments to the federal Fisheries Act would exempt the aquaculture industry from provisions that “prohibit the release of deleterious substances into water frequented by fish.” Coalition members are worried that the changes will result in pesticides routinely being dumped into the Bay of Fundy,  located between the Canadian provinces of Nova Scotia and New Brunswick, and remove Environment Canada’s role in aquaculture activities, said spokeswoman Maria Recchia, the executive director of the Fundy North Fishermen’s Association. Aquaculture, which refers to the breeding, rearing, and harvesting of aquatic organisms such as fish, shellfish, and plants, provides half of the world’s seafood. According to  Food and Water Watch, offshore aquaculture follows an industrial agriculture model which grows thousands of animals in a confined environment. For fish, however, this confined space is in the ocean, meaning all of the waste products from the operation flow directly into the ocean. This includes excess feed and chemicals that are used, such as antibiotics and pesticides, to treat or prevent […]

(Beyond Pesticides, August 14, 2014) Pesticides are not the first thing to pop into mind when peering into a hot mug of steaming, pale green or murky black tea first thing in the morning. A recent report published by Greenpeace India announced the results of an investigation that tested for pesticide residues in branded tea. The verdict? Nearly 94% of the tea samples tested contained at least one of 34 different pesticides, while over half contained a toxic cocktail of more than 10 different pesticides. The residues found include DDT, which was banned for use in agriculture in India since 1989, and endosulfan, which was banned in 2011 by the Indian Supreme Court. Over half of the 49 samples contained illegal pesticides — either those that are not approved for use in tea cultivation or exceeded recommended limits. These pesticides include ones that have been long banned from agriculture and use in tea cultivation (DDT and triazophos), suspected mutagens and neurotoxicants (monocrotophos), and insecticides associated with the global decline in bee populations (neonicotinoids like thiacloprid and thiamethoxam). The most frequently detected pesticides include thiamethoxam (78%), cypermethrin (73%), acetamiprid (67%), thiacloprid (67%), DDT (67%), deltamethrin (67%), dicofol (61%), imidacloprid (61%), and […]

(Beyond Pesticides, June 21st, 2012) A new study details the toxic effects of long-term exposure to commonly used agricultural pesticides. Results indicate an increased likelihood of moderate to severe blood toxicity and a reduced total number of bone marrow cells, which can lead to degenerative diseases like aplastic anemia. The study, entitled “Pesticide Induced Alterations in Marrow Physiology and Depletion of Stem and Stromal Progenitor Population: An Experimental Model to Study the Toxic Effects of Pesticide” is published in the online version of the Journal of Environmental Toxicology . The experiment, led by researchers at the Calcutta School of Tropical Medicine’s Department of Biochemistry and Medical Biotechnology, exposed a group of mice to a mixture of organochlorine, organophosphate and pyrethriod pesticides, including a preponderance of the chemicals cypermethrin, and chloropyrofos. The exposed mice showed an overall reduction in the ability of their bodies to produce bone marrow cells. Bone marrow, the soft flexible tissue found in the interior of bones, is a storehouse for stem cells. While the exact mechanism is unknown to researchers, the study reveals that the microenvironment in which stem cells develop is somehow deranged by pesticides. This derangement prevents the maturation of stem cells into every […]

(Beyond Pesticides, November 14, 2011) Environment Canada’s enforcement division has indicted the multinational firm Cooke Aquaculture and three of its senior officials on eleven criminal charges stemming from illegal pesticide applications that spread to sicken and kill wild lobsters. The indictment alleges that in 2009 Cooke applied cypermethrin, a pesticide prohibited for use in aquatic settings in Canada, to control sea lice infestations in open water salmon net pens. The alleged applications occurred in the Passamaquoddy Bay which separates the Canadian province of New Brunswick from Maine and feeds into the Bay of Fundy. After dead and weakened lobsters were discovered in Canadian waters in the fall of 2009 and early 2010, Environment Canada linked the incidents to cypermethrin exposure and raided eight Cooke facilities. A conviction on the first count could result in a fine of $1 million with subsequent counts punishable by a $1 million fine or three years in prison, or both. Cypermethrin is a synthetic pyrethroid used for insect control in a number of agricultural and structural pest management settings. EPA has identified cypermethrin as a possible human carcinogen and classifies formulated pesticides containing it as slightly or moderately toxic. According to Susan Shaw, Ph.D., director […]

(Beyond Pesticides, August 11, 2011) A combination of eleven different kinds of commonly used pyrethroids were tested on mice in a new study which found that, at real-world exposure levels, the insecticides can produce heightened toxicity that is equal to the sum of each insecticide’s individual effect. The mixture of similar-acting insecticides works by over-stimulating electronic channels in the mouse’s brain cells and eventually causing death. This study adds to the growing body of research on the toxicity of pesticide combinations in nature and showcases the need for policy change because the current risk assessment approach to regulating pesticides fails to look at chemical mixtures and synergistic effects. The U.S. Environmental Protection Agency (EPA) currently regulates on a chemical-by-chemical basis, but as this study demonstrates, interacting chemicals can have synergistic effects at very low levels, where a “chemical cocktail” of multiple interacting chemicals combine to have greater effects than expected. Pesticides can also have a cumulative “toxic loading” effect both in the immediate and long term. Researchers exposed mice brain cells to eleven different food-use pyrethroid insecticides either singly or in a mixture in the study entitled ”Additivity of pyrethroid actions on sodium influx in cerebrocortical neurons in primary culture.” […]

(Beyond Pesticides, October 19, 2010) In addition to the ongoing investigation into the death of nearly 1,000 lobsters last fall around waters in New England and Canada, Environment Canada is now investigating the possible release of a pesticide that is not permitted for use in Canada. The pesticide, cypermethrin, is used in the U.S., including Maine, to control sea lice outbreaks in salmon farms, a practice under investigation. Cypermethrin is toxic to lobsters, and fishermen associations have been calling for the elimination of the use of pesticides in the marine environment. Fish farmers have been challenged in controlling sea lice outbreaks this summer, particularly in the upper Passamaquoddy Bay area. They have been using other chemicals to control the outbreaks, including hydrogen peroxide, Salmosan (azamethiphos), SLICE (emamectin benzoate) and Calicide (teflubenzuron). New Brunswick aquaculture organizations have maintained that fish farmers do not use cypermethrin, which is not permitted for use there. The New Brunswick Salmon Growers Association referred to the cocktail of pesticides used on salmon farms as “medicine” and referred to salmon farming techniques as “natural.” However, shoddy farming practices, such as growing too many fish per site and having too many sites in the same area, can lead […]

(Beyond Pesticides, February 18, 2010) Hundreds of dead and dying lobsters just north of the Gulf of Maine were found to have been exposed to cypermethrin, a highly toxic synthetic pyrethroid pesticide registered for agricultural and residential use that some officials think may have been illegally used in fish farming. However, the chemical, which is primarily used for indoor insect control and termites, is extremely toxic to fish and aquatic organisms and part of a family of pesticides (synthetic pyrethroids) that is increasingly showing up in water bodies at toxic levels, a cause for concern according to scientists. Area fisherman are angry and concerned, however investigators are not yet certain just how this pesticide wound up in the Bay of Fundy, which is located between the Canadian provinces of Nova Scotia and New Brunswick. The first dead lobsters were discovered last fall in Grand Manan’s Seal Cove, and only a few days later fisherman found dead lobsters in two different locations in the Bay, including about 816 kilograms of dying or dead lobsters in Deer Island’s Fairhaven Harbour. This prompted an investigation by Environment Canada that began on December 22, 2009. The department looked at samples of crab, kelp, mussels […]