(Beyond Pesticides, April 28, 2022) A study in Environmental Research finds that glyphosate’s primary metabolite (breakdown product), aminomethylphosphonic acid (AMPA), induces DNA damage through oxidative stress among subpopulations of primary school children. Although pyrethroid and chlorpyrifos metabolites can induce oxidative stress, this study is the first to investigate AMPA’s association with adverse health effects, rather than solely the effects of the active ingredient, glyphosate, in Roundup and other formulations. Glyphosate is the most commonly used active ingredient worldwide, appearing in many herbicide formulations, readily contaminating soil, water, food, and other resources. Chemical use has been increasing since the inception of crops genetically modified to tolerate glyphosate. However, studies demonstrate glyphosate is among the most prevalent pesticide contributors to human, biotic, and ecosystem harm. According to research, herbicide toxicity to invertebrates has doubled since 2004. Although research links glyphosate exposure to cancer, specifically non-Hodgkin lymphoma, much less research considers the effects that metabolites have on children who are more vulnerable to chemical exposure. Ecological and health risk assessments primarily focus on active ingredients in pesticide products, overlooking the potential impacts of metabolites. Thus, studies like these highlight the need to assess the implications of metabolite exposure to protect human, animal, and environmental health. The study notes, “Our […]

(Beyond Pesticides, March 9, 2022) In response to local concerns around children’s environmental exposures, the Minnesota Department of Health (MDH) recently published biomonitoring data collected from young children living in urban and rural areas of the state. The findings provide local residents and lawmakers with baseline data on the hazards children are encountering where they live, learn, or play, and point to ways in which families can reduce or eliminate these dangers. With evidence that early life exposures during “critical windows of vulnerability” increase risk of long-term health problems, it is critical for state agencies to both collect data, and take meaningful action to protect children from future harms. Minnesota lawmakers established a state biomonitoring program in 2007, and have since expanded the project. The current report represents the results of MDH’s Healthy Rural and Urban Kids Project aimed at biomonitoring chemicals in young children. For this round, the agency focused on preschool-aged children living in MN’s rural Becker, Todd, and Wadena counties, as well as those living in urban North Minneapolis. MDH enrolled 232 families during the summer of 2018, provided them with a questionnaire, and tested children for 21 different chemicals in their urine. The chemicals tested were […]

(Beyond Pesticides, February 9, 2022) Insecticide use during pregnancy significantly increases the occurrence of Otitis Media (OM) in infants, according to research published in Scientific Reports from a team of Japanese researchers late last month. Otitis Media, an infection of the space behind the ear drum, is a common disease among children. While most infections go away on their own, some children experience pain, fever, and in some cases complications that result in hearing loss. This research underscores the myriad of dangers and diseases that pesticide use can precipitate, which are not considered under risk assessments conducted by the U.S. Environmental Protection Agency (EPA). Scientists collected their initial data from the ongoing Japan Environment and Children’s Study, a national birth cohort study that evaluates environmental factors affecting children’s health in Japan. Data recorded include factors such as maternal age, birth weight, and gestation weeks, and mothers provided answers to a range of questionnaires, including one relating to exposure to insecticides during pregnancy. Study authors utilized a range of other covariates to control for further risk factors, such as family history of OM, living with other siblings, nursery attendance, parental smoking habits, and others. The study determined that OM during an […]

(Beyond Pesticides, January 5, 2022) Household pesticide use is associated with harmful impacts to infant motor development, according to a study published late last year in the journal Paediatric and Perinatal Epidemiology. The research focused on primarily low-income Hispanic women located in Los Angeles, California, enrolled in an ongoing study referred to as Maternal and Developmental Risks from Environmental and Social Stressors (MADRES). As with other pollutants in society, low-income, people of color communities are disproportionately in contact with toxic pesticides, resulting in exposures that can start early, and affect health over the course of one’s lifetime. Women enrolled in the MADRES cohort are over the age of 18, and speak English or Spanish fluently. For the present study, roughly 300 MADRES participants met the criteria for enrollment, and completed household pesticide use questionnaires at a 3-month post-natal visit. The questionnaire generally inquired whether pesticides had been used in one’s home since their child was born. After another 3 months, researchers also tested infants’ motor development using an Ages and Stages-3 protocol screening tool, which evaluates a child’s ability to execute muscle movements. Overall, roughly 22% of mothers reported pesticide use in their home during the first months of their […]

(Beyond Pesticides, November 18, 2021) A study published by King George’s Medical University, India, finds exposure to xenobiotic substances like pesticides during pregnancy increases risks associated with preterm birth, including a rise in cesarean section (C-section) deliveries and a decrease in fetal body weight. Preterm births occur when a fetus is born early or before 37 weeks of complete gestation. Premature births can result in chronic (long-term) illnesses among infants from lack of proper organ development and even death. Birth and reproductive complications are increasingly common among individuals exposed to environmental toxicants, like pesticides. The Center for Disease Control (CDC) reports the preterm birth rate is increasing annually. Therefore, studies like this can help government and health officials safeguard human health by assessing adverse effects following prevalent chemical exposure. The study notes, “To the best of our knowledge, this was a pioneering study, and it may help to increase our knowledge with regard to xenobiotic exposure in biological systems and the need for stringent guidelines for agricultural use of pesticides.” The study examines the association between the transfer of xenobiotics (foreign synthetic substances like pesticides) from mother to fetus. Transferal of these toxic substances can result in biological and chemical changes (i.e., genotoxicity […]

(Beyond Pesticides, November 15, 2021) A recent hearing in the U.S. Senate Agriculture Subcommittee on Food and Nutrition, Specialty Crops, Organics, and Research, subcommittee chair Senator Cory Booker stressed the failures of the U.S. Department of Agriculture’s (USDA) food and nutrition programs, saying, “Our food system is not a “free market,” we are picking winners and losers, and it’s consumers, family farmers, and food workers who are losing.” Tell USDA’s Food and Nutrition Service to require organic school lunches. Experts at the hearing pointed out impacts of poor nutrition choices that are driven by USDA’s policies. Associate professor Angela Odoms-Young, PhD of Cornell University said, “People of color overall, and Black populations specifically, face higher rates of diet-related chronic conditions and have poorer dietary intakes as compared to whites. We did not get here by chance but through policy.” Childhood obesity is a serious problem in the U.S., leading to a host of health problems in childhood and later in life. Juvenile obesity is highest in Hispanic, African American, and lower income groups, which provides an opportunity for USDA’s school lunch program to have a positive impact. At the hearing, Donald Warne, MD, MPH of the University of North Dakota medical […]

(Beyond Pesticides, September 16, 2021) A study published in Chemosphere finds persistent organic pollutants (POPs), including organochlorine pesticides (OCPs), polychlorinated biphenyls (PCBs), and polybrominated diphenyl ethers (PBDEs), are present in the serum and placenta of pregnant mothers, as well as multiple fetal organs. Many studies indicate prenatal and early-life exposure to environmental toxicants increases susceptibility to diseases, from learning and developmental disabilities to cancer. However, this study is one of the first to demonstrate the presence of chemical toxicants in fetal tissue that are not present in maternal serum or placental samples. Prenatal development is one of the most vulnerable periods of exposure when the fetus is most susceptible to the harmful effects of chemical contaminants. Therefore, studies like these help government and health officials better identify fetal exposure contaminants and subsequent health concerns otherwise missed by current chemical monitoring methods. The researchers note, “These findings call for further evaluation of the current matrices used to estimate fetal exposure and establish a possible correction factor for a more accurate assessment of exposure in utero. We disclose the full data set on individual exposure concentrations to assist in building in silico models for prediction of human fetal exposure to chemicals.” Several studies associate early-life exposure to toxic chemicals […]

(Beyond Pesticides, September 1, 2021) A study published in Environmental Pollution finds the risk of acute childhood leukemia (AL) increases with prenatal and newborn exposure to pesticides (i.e., insecticides and herbicides). The study results support the hypothesis that chronic environmental pesticide exposure increases childhood leukemia risk up to two times. Maternal exposure has a stronger association with leukemia than childhood exposure. Insecticides and herbicides are of particular significance in increasing leukemia risk, especially for acute lymphoblastic leukemia. Although medical advancements in disease survival are more prominent nowadays, childhood AL remains the secondary cause of child mortality following physical injury. Furthermore, childhood leukemia survivors can suffer from chronic or long-term health complications that may be life-threatening. Although the etiology or cause of childhood AL involves the interaction of multiple components like lifestyle and genetics, emerging evidence indicates that environmental contaminants like pesticides (e.g., occupational exposures, air pollution, pesticides, solvents, diet, etc.) play a role in disease etiology. Pesticide contamination is widespread in all ecosystems, and chemical compounds can accumulate in human tissues resulting in chronic health effects. Children are particularly vulnerable to the impacts of pesticide exposure as their developing bodies cannot adequately combat exposure effects. Already, studies find low levels of pesticide exposure during […]

(Beyond Pesticides, August 30, 2021) As with other actions on pesticides, EPA’s chlorpyrifos decision is filled with exceptions that respond to vested interests seeking to ignore or deflect the science. EPA, since announcing its decision in 1999 to ban “residential” uses of chlorpyrifos, continues to allow the following uses: (i) Residential use of containerized baits; (ii) Indoor areas where children will not be exposed, including only ship holds, railroad boxcars, industrial plants, manufacturing plants, or food processing plants; (iii) Outdoor areas where children will not be exposed, including only: golf courses, road medians, Industrial plant sites; (iv) Non-structural wood treatments including: fenceposts, utility poles, railroad ties, landscape timers, logs, pallets, wooden containers, poles, posts, and processed wood products; (v) Public health uses: Fire ant mounds (drench and granular treatment); (vi) nurseries and greenhouses; and (vii) Mosquito control. These uses are unaffected by EPA’s announcement. We need to finish the chlorpyrifos job. Tell EPA to ban all uses of chlorpyrifos. The collective effort to remove this one chemical is a tremendous feat in eliminating one exposure to a hazardous material for children. Achieving the ban on food uses required an enormously resource-intensive effort at a time in history when we are […]

(Beyond Pesticides, August 26, 2021) A recent study published in Environmental Research demonstrates that exposure to the herbicide glyphosate and its breakdown product reduces pregnancy length, increasing the risk of preterm birth. Preterm births occur when a fetus is born early or before 37 weeks of complete gestation. Premature births can result in chronic (long-term) illnesses among infants from lack of proper organ development and even death. Birth and reproductive complications are very common among individuals exposed to environmental toxicants, like pesticides. Considering the Center for Disease Control (CDC) reports the preterm birth rate is increasing annually, studies like this can help government and health officials safeguard human health by assessing adverse health effects following prevalent chemical exposure. The study notes, “Given the prevalent and rising exposures to glyphosate and GBHs [glyphosate-based herbicides], confirmatory studies are needed to explore reproductive effects of glyphosate and GBHs to re-assess their safety on human health and to explore possible programming consequences to lifelong health.” GBHs are the most commonly used herbicides, readily contaminating soil, water, and food globally. Although GBHs’ ubiquitous nature has been linked to carcinogenic effects, specifically non-Hodgkin lymphoma, much less research considers exposure effects on reproductive health. The study’s scientists aimed to examine the relationship […]

(Beyond Pesticides, July 20, 2021) Chlorpyrifos exposure results in the expression of genetic mutations associated with autism spectrum disorder in a laboratory model, finds research published in Environmental Health Perspectives by scientists at Johns Hopkins Bloomberg School of Public Health. “This is a step forward in showing an interplay between genetics and environment and its potential role for autism spectrum disorder,” says study lead Lena Smirnova, PhD, a research associate in the Department of Environmental Health and Engineering at the Bloomberg School. The findings support reams of research already conducted that show strong associations between autism and exposure to hazardous environmental stressors like toxic pesticides. Scientists conducted their study using a ‘brain organoid’ model, which is essentially a cluster of cells artificially grown in the lab from stem cells in order to mimic a developing human brain. These tests provide certain benefits over animal testing, as they are more relevant to human disease, and can be performed faster with less cost. The organoid model also represents an improvement on typical 2d cell-based models, increasing cell survival, shelf-life, and thus providing opportunity to model for later stages of brain development. Brain organoids in this study carried a gene called CHD8, which […]

(Beyond Pesticides, July 7, 2021) Organic food consumption among children is associated with higher scores on tests measuring fluid intelligence and working memory, research published in the journal Environmental Pollution finds. The study, conducted by Spanish researchers based at the Barcelona Institute for Global Health, took an exposome approach to environmental exposures, looking at a totality of all environmental hazards that children encounter, rather than investigating individual lifestyle factors one by one. As study co-author Jordi Júlvez, PhD, notes, “healthy diets, including organic diets, are richer than fast food diets in nutrients necessary for the brain, such as fatty acids, vitamins and antioxidants, which together may enhance cognitive function in childhood.” Researchers began their study by selecting mother-child pairs enrolled in the Human Early-Life Exposome (HELIX) Project, a pan-European study with projects in multiple European countries. Nearly 1,300 healthy children aged 6-11 were included in the study, as researchers already had pregnancy data and urine samples stored on the participants. To determine other environmental exposures, home addresses were evaluated for their level of pollution and proximity to natural spaces, and children and their mothers were given tests that included a questionnaire on lifestyle factors, including parents smoking and alcohol use, […]

(Beyond Pesticides, May 21, 2021) Do those ideas scratch your curiosity, science, policy, agriculture, and/or activist itch? Great — because the 2021 Annual National Pesticide Forum, Cultivating Healthy Communities: Confronting Health Threats, Climate Disasters, and Biodiversity Collapse with a Toxic-Free Future — begins very soon, so it is time to register! Cultivating Healthy Communities is a singular opportunity to learn from top experts and connect with kindred people from all over the U.S. (as well as with some international participants). During plenary sessions, presenters will share their understandings and ideas about the problems we face, and about urgently needed strategies and solutions to solve them. The workshop sessions will be interactive, providing attendees the chance to interact with one another and presenting experts. This annual National Pesticide Forum conference is convened, in 2021, by Beyond Pesticides and the Icahn School of Medicine at Mt. Sinai’s Institute for Exposomic Research. (“Exposomic” references the multitude of environmental factors to which an individual is exposed, and which can have effects on health.) If you are groaning or rolling your eyes at the thought of yet another conference, know that Cultivating Healthy Communities is not one of those events (think old school, boring, and expensive, […]

(Beyond Pesticides, May 17, 2021) The U.S. Environmental Protection Agency (EPA) has less than two months to decide whether to cancel or modify its registration of the brain-damaging organophosphate insecticide chlorpyrifos, following a decision from a federal appeals court. The ruling comes after more than a decade of delay from the federal agency tasked with protecting public health and the environment from the hazards of chemicals like chlorpyrifos. The decision now falls to the Biden Administration’s EPA Administrator Michael Regan, after the previous administration reversed a proposal to ban agricultural uses of chlorpyrifos in 2017. Most residential uses of the chemical were banned in 2000.  Tell EPA to ban chlorpyrifos and other neurotoxic pesticides. The target of action by which chlorpyrifos and many other pesticides kill is the nervous system. It is not surprising, then, that pesticides also target the nervous system in humans. They are particularly hazardous to children, who take in greater amounts of pesticides relative to their body weight than adults, and whose developing organ systems are typically more sensitive to toxic exposures. The body of evidence in the scientific literature shows that pesticide exposure can adversely affect a child’s neurological, respiratory, immune, and endocrine systems, even at […]

(Beyond Pesticides, April 22, 2021) Past maternal exposure to the pesticide dichlorodiphenyltrichloroethane (DDT) during pregnancy can increase the risk of breast cancer and cardiometabolic disorders (e.g., heart disease, obesity, diabetes) up to three successive generations, according to a new study published in Cancer Epidemiology, Biomarkers & Prevention. Although previous studies highlight early life or in utero exposure to DDT increasing breast cancer risk later in life, this study is the first to note generational effects on grandchildren’s health. DDT continues to adversely affect the health of the U.S. population, nearly 50 years after its ban. However, this ban is not global, as many countries still use or manufacture the chemical compound. Furthermore, residues of DDT metabolite, DDE, continue to readily contaminate food and water worldwide. Therefore, studies like these highlight the need to investigate how first-generation pesticide exposure can impact future generational health in order to prevent adverse health outcomes, especially during sensitive developmental periods (i.e., in utero, infancy/childhood). The study researchers note, “Discovery of actionable biomarkers of response to ancestral environmental exposures in young women may provide opportunities for breast cancer prevention.” To assess the association between multi-generational health risks and chemical exposure, researchers used the Public Health Institute’s Child […]

(Beyond Pesticides, April 15, 2021) Gestational (during pregnancy) and childhood exposure to per- and polyfluoroalkyl substances (PFAS) increase cardiometabolic risk, or the risk of heart diseases and metabolic disorders, later in life, according to a Brown University study published in Environment International. Past studies associate exposure to chemical pollutants with increased susceptibility to adverse health effects during critical fetal and childhood developmental periods. Some of these health effects are cardiometabolic risk factors, including obesity, insulin issues, abnormal blood pressure, that increase the risk of developing cardiovascular disease (CVD) and metabolic disorders (e.g., type 2 diabetes). PFAS are of particular concern as these endocrine-disrupting chemicals are common in non-stick cookware, cleaning/personal care products, food packaging, and other consumer products. They are now being found in pesticide products. Because of their ubiquitous use in many products, studies report that PFAS compounds are detectable in infants, children, and pregnant women. Furthermore, pregnant women can readily transfer compounds to the developing fetus through the placenta. Cardiovascular disease and diabetes are among the leading causes of death globally. Additionally, heart conditions are one leading cause of disability in the U.S., as research demonstrates environmental pollutant exposure can increase the risk of developing cardiovascular disease, including stroke, heart attack, heart failure, atrial fibrillation, and cardiac […]

(Beyond Pesticides, April 6, 2021) Pregnant women living within 2.5 miles of agricultural pesticide applications have an increased risk that their child will develop central nervous system (CNS) tumors, according to a study published in the journal Environmental Research by a team at University of California, Los Angeles. The results are particularly concerning as it reveals that individuals do not have to be in close contact with pesticides for risky, health-harming exposures to occur. “This transition from farmland to residential neighborhoods is abrupt across California, and, of course, constantly changing as farmland is developed,” said study co-author Myles Cockburn, PhD. “The simplest way to mitigate these risks is by reductions in exposure to pesticides, through restrictions to aerial spraying and air blast that lead to increased drift, and by farming methods that decrease reliance on pesticides.” Researchers note that the present study is unique in that it was able to pinpoint the specific pesticides related to the development specific types of tumors. To make these determinations, scientists made use of California’s Cancer Registry records. Diagnosed children aged 0-5 were matched to maternal residences where pesticide applications were made within 4000 meters (~2.5 miles). Pesticide application records were obtained from data […]

(Beyond Pesticides, March 25, 2021) A new University of California San Francisco (UCSF) study, published in Environmental Science & Technology, finds over 100 chemicals present in U.S. pregnant women’s blood and umbilical cord samples. This discovery ignites concerns over prenatal exposure to chemicals from consumer and industrial products and sources. Furthermore, 89 percent of these chemical contaminants are unknown sources and uses, lacking adequate information, or are not previously detectable in humans. The National Health and Nutrition Examination Survey (NHANES) finds U.S. pregnant women experience frequent exposure to environmental pollutants that pose serious health risks to both mother and newborn. Many known environmental pollutants (i.e., heavy metals, polychlorinated biphenyl, and pesticides) are chemicals that can move from the mother to the developing fetus at higher exposure rates. Hence, prenatal exposure to these chemicals may increase the prevalence of birth-related health consequences like natal abnormalities and learning/developmental disabilities.  Current chemical biomonitoring methods only analyze a targeted few hundred chemicals—a small portion of the over 8000 chemicals the U.S. manufactures and imports. However, this study employs new technology that identifies a more comprehensive range of industrial chemicals. Therefore, research like this is essential for future technological development that can identify likely omnipresent chemical exposures for future health risks. UCSF scientists […]

(Santa Fe, New Mexico, February 11, 2021)—New Mexico State Senator Brenda McKenna  introduced the Public Schools Pesticide Management Act (PSPMA) (SB 326) in order to protect school children from exposure to toxic pesticides where they learn and play. The legislation advances ecological pest management, an environmentally healthy way to protect children and the public from weeds and pests, within all schools, classrooms, community parks, and playgrounds in the state. Under PSPMA, only organic and minimum risk pesticides, the least toxic, yet still-effective products on the market will be allowed. Toxic pesticide use will be permitted only under a defined public health emergency, as determined by a public health official. The law does not address the use of pesticides in farming or agriculture.  “All children in New Mexico have the right to a safe environment where they learn and play,” said State Senator Brenda McKenna. “This legislation embraces an environmentally healthy approach to pest management, so families do not have to worry about the use of toxic pesticides in schools and communities.” Pesticide exposure presents unique dangers to children’s health. Children’s developing organ systems are less able to detoxify harmful chemicals, and they often come into closer contact with pesticides than adults in […]

(Beyond Pesticides, December 23, 2020) The litany of parting shots by the waning Trump administration got longer on December 4, when the Environmental Protection Agency (EPA) announced a proposed interim decision on the very toxic pesticide chlorpyrifos, functionally continuing its registration for many agricultural uses. The interim decision purports to put in place new limitations on use of this pesticide, but they are wholly inadequate to the threat this compound represents — to young children, most concerningly, as well as to farmworkers, critical species and ecosystems, and the public. Chlorpyrifos should not be re-registered for use — i.e., its sale and use should be banned altogether, as Beyond Pesticides has asserted for years. Chlorpyrifos is an organophosphate pesticide used on scores of food crops, for mosquito (and other pest) control, and for some turf management (golf courses, especially). It has been demonstrated to be highly neurotoxic, especially to young children, leading to impaired cognitive function, developmental delays, lower IQs, attention deficit disorder, and a variety of other pervasive developmental and learning disorders. The essence of the compound’s toxicity to developing brains lies in its function as a cholinesterase inhibitor; chlorpyrifos binds to the receptor sites for acetylcholinesterase (AChE), an enzyme […]

(Beyond Pesticides, November 25, 2020) New research from the Centre for Environment and Occupational Health Research at the University of Cape Town (UCT), South Africa, finds a link between pesticide exposure and adverse neurological symptoms among children and adolescents living in agricultural areas. Considering the etiology (cause) of many brain and neurological disorders are unknown, research like this is significant for understanding how pesticide exposure promotes disease development, especially among vulnerable populations. Researcher notes, “Children who indicate activities related to pesticide exposure may be at higher risk for developing headaches and lower cognitive performance in the domains of attention, memory and processing speed. […]Given [the] history and socio-economic divide to the farm laborers, […]future interventions should aim to reduce the health risks of these vulnerable populations, including their children.” The study demonstrates that there is a relationship between pesticide exposure from various farm-related and leisure activities and headaches and neurocognitive functioning (i.e., autism, attention deficit hyperactivity disorder (ADHD), lower intelligence (IQ), and harmful social behavior and behavioral regulation) in children and adolescents. To assess which farm-related/leisure activities concerning pesticide exposure cause cognitive symptoms, researchers administered a questionnaire addressing child pesticide handling, direct consumption of field crops, interaction with field adjacent water sources, […]

(Beyond Pesticides, October 23, 2020) In central California, what promises to be a landmark series of lawsuits against Corteva (formerly DowAgroSciences), maker of the pesticide chlorpyrifos, is under way, spearheaded by the case Alba Luz Calderon de Cerda and Rafael Cerda Martinez v. Corteva Inc., et al. This first suit, brought by the parents of Rafael Cerda Calderon, Jr. on his behalf, charges that his lifelong disabilities were caused by chronic exposures to chlorpyrifos. The parents are suing for general damages, compensatory damages (due to Rafael, Jr.’s loss of earning capacity), medical care costs, and “punitive damages for the willful, reckless, and recklessly indifferent conduct of the Defendants” in intentionally hiding the dangers of their chlorpyrifos products from customers and the public. As with so many dangerous pesticides, absent effective federal regulation, states, cities, and other entities are taking action to protect people from this compound, and as in this case, individuals are seeking redress for harms suffered. Beyond Pesticides has long advocated for a ban on the use of chlorpyrifos because of the grave risks it poses. The case was filed in mid-September in California Superior Court, Kings County, and names not only Corteva, but also, the cities of Huron and Avenal, Woolf […]

(Beyond Pesticides, October 2, 2020) The U.S. Environmental Protection Agency’s (EPA) September 22 announcement asserts that, “despite several years of study, the science addressing neurodevelopmental effects [of the insecticide chlorpyrifos] remains unresolved,” as reported in The New York Times. This conclusion contradicts both ample scientific evidence and the agency’s own findings. Beyond Pesticides has repeatedly advocated for a ban on the use of chlorpyrifos because of the grave risks it poses. This organophosphate pesticide is used on approximately 60 different crops, including almonds, cotton, citrus fruits, grapes, corn, broccoli, sugar beets, peaches, and nectarines. It is also commonly employed for mosquito-borne disease control, and on some kinds of managed turf, including golf courses. Exposure to the pesticide has been identified repeatedly as problematic. Most residential uses were taken off the market in 2000, after the manufacturer, DowDupont (now Corteva) was faced with EPA action. Chlorpyrifos is a cholinesterase inhibitor that binds irreversibly to the receptor sites of acetylcholinesterase (AChE), an enzyme that is critical to normal nerve impulse transmission. In so doing, chlorpyrifos inactivates the enzyme, damages the central and peripheral nervous systems, and disrupts neurological activity. The compound is associated with harmful reproductive, renal, hepatic, and endocrine disrupting effects, and most […]