17
Jul
(Beyond Pesticides, July 17, 2008) In a new study published in Environmental Health Perspectives, researchers have found an increased occurrence of intersex toads in areas with greater agricultural land cover. This points to a link between certain pesticides and endocrine disruption, a change in the hormonal balance that can have sexual and reproductive effects. Such results implicate pesticides in the decline of amphibian populations, and suggests that these chemicals are also adversely affecting humans. The study, which was conducted in south Florida, looked at cane toads, Bufo marinus, at five sites with differing land use patterns ranging from suburban to nearly completely agricultural (primarily sugarcane and vegetables). Researchers examined physical characteristics such as coloration, sexual organs, and forelimb length, as well as hormone concentrations, and found a higher rate of feminization for toads in agricultural areas. In these areas, glyphosate (the active ingredient in Round Up herbicide) and atrazine (an herbicide) use is common. Tyrone Hayes, PhD, was one of the first to document the endocrine disrupting effects of atrazine on frogs in a laboratory setting. Countering any doubts of why this work is important, Dr. Hayes said, “People often say, ”˜It is just frogs, so who cares?’ Well it […]
Posted in Atrazine, Disease/Health Effects, Endocrine Disruption, Florida, Glyphosate, Wildlife/Endangered Sp. | No Comments »
30
May
(Beyond Pesticides, May 30, 2008) A recent study has linked the common herbicide atrazine with endocrine disruption in both fish and human cells. Entitled “The Herbicide Atrazine Activates Endocrine Gene Networks via Non-Steroidal NR5A Nuclear Receptors in Fish and Mammalian Cells,” the University of Califonia, San Francisco (UCSF) research examines the reaction of zebrafish to environmentally relevant levels of atrazine, and mirrors the study in human placental cells. The zebrafish, which are particularly sensitive to endocrine disruptors, Â are “feminized” Â in greater proportion than the unexposed control group. Fish exposed to atrazine for 48 hours at levels found in agricultural runoff produced twice as many female fish as male. “These fish are very sensitive to endocrine disrupting chemicals, so one might think of them as ‘sentinels’ to potential developmental dangers in humans,” said senior author Holly Ingraham, PhD. “These atrazine-sensitive genes are central to normal reproduction and are found in steroid producing tissues. You have to wonder about the long-term effects of exposing the rapidly developing fetus to atrazine or other endocrine disruptors.” In human cell studies, the researchers found that atrazine activates genes involved in hormone signally and steroid synthesis. “Endocrine-related cell types with a capacity for steroid generation appear […]
Posted in Atrazine, Endocrine Disruption, Water | No Comments »
08
May
(Beyond Pesticides, May 8, 2008) New research shows that melting Antarctic glaciers are releasing once frozen stores of persistent organic chemicals, now banned in many parts of the world. Marine biologist, Heidi Geisz, a Ph.D. student at the Virginia Institute of Marine Science studying the fate and effect of organic contaminants in the Antarctic, has found that DDT concentrations in penguins has remained at the same levels as they were 30 years ago, when DDT was widely used. Arctic animals such as whales, seals and birds have had a significant decline in their DDT levels during the past decades, while the more stationary Antarctic penguins have not. The study, “Melting Glaciers: A Probable Source of DDT to the Antarctic Marine Ecosystem,” published in Environmental Science and Technology (DOI: 10.1021/es702919n), identifies the melting snow and ice as the continued source of total DDT in this southern ecosystem. The release of DDT also means that other persistent organic pollutants (POPs), including PCBs and PBDEs — industrial chemicals that have been linked to health problems in humans, are also being released. “DDT is not the only chemical that these birds are ingesting and it is certainly not the worst,” Ms. Geisz says. Ms. […]
Posted in Climate Change, DDT, Endocrine Disruption, Water, Wildlife/Endangered Sp. | 1 Comment »
10
Apr
(Beyond Pesticides, April 10, 2008) Common frogs that live in suburban areas are more likely than their rural counterparts to develop reproductive abnormalities, according to David Skelly, PhD, professor of ecology at the Yale School of Forestry and Environmental Studies. This phenomenon becomes a serious concern as the frog’s mating season begins, leaving researchers to wonder: will frogs be clear on their role in the annual ritual? Research by Dr. Skelly, soon to be published, focuses on the common green frog, Rana clamitans, within the Connecticut River Valley. A total of 233 frogs were collected from various ponds and landscapes with the river valley and among them 13 percent have abnormalities occurring in their reproductive organs. In urban areas, 18 percent of the collected frogs are intersex, and in suburban areas 21 percent. Frogs collected from agricultural areas have the lowest rate of reproductive problems with just 7 percent classified as intersex. According to Dr. Skelly, the more suburban the land cover, the more likely the abnormalities. “This is the first evidence that I think anyone has provided that agriculture is doing anything but pushing those rates higher,” remarked Dr. Skelly of the intersex phenomena. In an attempt to explain […]
Posted in 2,4-D, Antibacterial, Atrazine, Endocrine Disruption, Glyphosate, Permethrin, Water, Wildlife/Endangered Sp. | 1 Comment »
19
Feb
(Beyond Pesticides, February 19, 2008) Common household chemicals and widespread pollutants are changing male reproductive health and impacting sexual function, development and cancer rates of today’s generations and possibly their offspring, according to more than 15 years of research by a Colorado State University expert. For example, one study looking at sperm counts globally from 1940, when chemicals first began to be widely produced, to the 1990s, indicates a 1.15 percent per year decline in sperm counts. These declines may be linked to chemical exposure.Rao Veeramachaneni, BVSc, MScVet, PhD, a biomedical sciences professor in the College of Veterinary Medicine and Biomedical Sciences, has found that chemicals including pesticides, common pollutants in ground water, and chemicals in plastics, make-up and nail polish are on a growing list of culprits causing developmental abnormalities such as impaired sperm quality and impotence. Reproductive health can be compromised if males are exposed at various times in life spanning from in utero up to adulthood.Dr. Veeramachaneni’s findings span the globe and are across species lines, from humans to horses, wildlife to frogs. His research, coupled with the collective findings of other experts in the field, indicates a strong link related to pollutants, and incidence of such […]
Posted in Chemicals, Disease/Health Effects, Endocrine Disruption, Infertility | 1 Comment »
09
Jan
(Beyond Pesticides, January 9, 2008) Triclocarban, an antibacterial compound widely used as an additive to a range of household and personal care products including bar soaps, detergents, body washes, cleansing lotions, and wipes, has been found to have an amplification effect on the activity of natural hormones, which in turn can lead to adverse reproductive and developmental effects. In the study, published online November 29, 2007 in Endocrinology, researchers from University of California- Davis and Yale University investigated the endocrine disrupting properties of triclocarban and other polychlorinated diphenyl urea compounds by exposing human cells and rats to levels similar to those found in people. Triclocarban was found to have a synergistic interaction with the sex hormone, testosterone- present in both males and females. This interaction produced a positive, amplified biological effect, which is likely to hyperstimulate native sex hormones. This amplification of sex hormone activity occurs at the target cell and can result in developmental defects or decreased reproductive function. Researchers further explained that ovulation and ovarian function in females can be disrupted, while sperm quality can be decreased in males. The researchers also point out that the results of their study create a new category for endocrine disruptive substances […]
Posted in Antibacterial, Chemicals, Disease/Health Effects, Endocrine Disruption, Triclosan | 1 Comment »
11
Dec
(Beyond Pesticides, December 11, 2007) Arturo Rodriguez (UFW President), Devra Davis, Ph.D. (author and University of Pittsburgh professor of epidemiology) and Tyrone Hayes, Ph.D. (UC Berkeley professor of integrative biology) will be speaking at the 2008 National Pesticide Forum. The conference, Reclaiming Our Healthy Future: Political change to protect the next generation, will be held March 14-16, 2008 at the University of California, Berkeley. A native of Texas, Arturo S. Rodriguez has worked tirelessly to continue the legacy of Cesar Chavez since taking over the helm of the United Farm Workers of America (UFW) upon the death of its legendary founder in 1993. Beyond winning fair contracts for its workers, the UFW continues to work to protect farmworkers from pesticides and other workplace hazards. Recent union victories are agreements with Gallo Vineyards Inc. and Coastal Berry Co., the largest winery and the largest strawberry employer in the U.S., as well as pacts protecting winery workers in Washington and mushroom workers in Florida. Devra Davis, Ph.D., a renowned environmental health expert, is professor of epidemiology at the University of Pittsburgh Graduate School of Public Health. Dr. Davis was designated a National Book Award Finalist for her book, When Smoke Ran Like […]
Posted in Alternatives/Organics, Announcements, California, Children/Schools, DDT, Disease/Health Effects, Endocrine Disruption, Events, Leukemia, National Politics, State/Local | No Comments »
18
Oct
(Beyond Pesticides, October 18, 2007) In a scholarly review written by Theo Colborn, Ph.D. and Lynn Carroll, Ph.D., the authors point to the multigenerational effects of some pesticides that they say demand improved regulation to protect human and environmental health. The review, “Pesticides, Sexual Development, Reproduction, and Fertility: Current Perspective and Future Direction,” appears in the international journal Human and Ecological Risk Assessment (13:5, 1078 — 1110), September, 2007. The study points out a major deficiency in the U.S. Environmental Protection Agency’s regulation of pesticides under current health reviews and risk assessments. The authors call EPA’s pesticide registration system “outmoded” and one that has “almost completely missed the low-dose and endocrine system-mediated effects of pesticides.” The study reviews both epidemiological and laboratory data. In the abstract, the authors state the following: Improvements in chemical analytical technology and non-invasive sampling protocols have made it easier to detect pesticides and their metabolites at very low concentrations in human tissues. Monitoring has revealed that pesticides penetrate both maternal and paternal reproductive tissues and organs, thus providing a pathway for initiating harm to their offspring starting before fertilization throughout gestation and lactation. This article explores the literature that addresses the parental pathway of exposure […]
Posted in Chemicals, Children/Schools, DDT, Disease/Health Effects, Endocrine Disruption | 1 Comment »
24
Sep
(Beyond Pesticides, September 24, 2007) Seven representatives wrote to the EPA last Thursday, urging the government agency to act promptly to identify and screen products for dangerous endocrine-disrupting chemicals. The letter asks EPA Administrator Stephen Johnson to provide definite deadlines in the testing and control of endocrine disruptors, which are substances that interfere with the normal functioning of the endocrine system, responsible for hormonal and developmental processes. EPA’s regulation of these substances that mimic or alter natural hormonal processes has been slow and lacks direction to meet set goals promptly, according to the U.S. Representatives. “To date, EPA’s efforts in this area have been characterized by missed deadlines, prolonged delays, and inadequate incorporation of public input,” according to the letter from the House Committee on Oversight and Government Reform, chaired by Rep. Henry Waxman (D-California). Ranking Minority Member on the Committee Tom Davis (R-Virginia); Representatives Elijah Cummings (D-Maryland), Chris Van Hollen (D-Maryland), Wayne Gilchrest (R-Maryland), and Jim Moran (D-Virginia); and Delegate Eleanor Holmes Norton (D-D.C.) also signed the letter to EPA. Advocates say that EPA’s lack of urgency on endocrine disruptors leaves the American population and future generations at risk for adverse health effects from exposure to these substances through […]
Posted in Endocrine Disruption, Pesticide Regulation | No Comments »
12
Jun
(Beyond Pesticides, June 12, 2007) More than 10 years after being directed to do so by Congress, the Environmental Protection Agency (EPA) has announced that it will test 73 pesticides for their potential to damage the endocrine system and disrupt the normal functioning of hormones in the body, the agency announced in a press release yesterday. EPA is seeking comments on the draft list of 73 pesticides to be evaluated under the new screening regimen. The 1996 Food Quality Protection Act (FQPA) set a 1999 deadline for EPA to develop a battery of assays with which pesticide manufacturers will be required to screen their products as possible endocrine (hormonal) disrupters, similar to tests required to determine whether chemicals cause cancer, birth defects, genetic mutations, or other problems. EPA has repeatedly pushed back the deadline and despite claims to be “a leader in endocrine disruptor research,” EPA has yet to test a single chemical under the protocol. EPA draft list of 73 pesticide ingredients, including both active and inert ingredients, were chosen based on their relatively high potential for human exposure. According to the press release, priority was given “to pesticide active ingredients where there is the potential for human exposure […]
Posted in Endocrine Disruption, Pesticide Regulation | 1 Comment »
12
Apr
(Beyond Pesticides, April 12, 2007) A new study has found the proportion of boys born over the past three decades has unexpectedly dropped in both the United States and Japan. In all, more than a quarter of a million boys are missing, compared to what would have been expected had the sex ratio existing in 1970 remained unchanged. The study’s authors hypothesize that the skewed sex ratio may be linked to prenatal exposure to endocrine-disrupting chemicals such as pesticides. Although the researchers do not know why boys are taking a hit, they suspect contributing causes could include widespread exposure to hormone-mimicking pollutants by women during pregnancy and by men before they conceive children. “We hypothesize that the decline in sex ratio in industrial countries may be due, in part, to prenatal exposure to metalloestrogens and other endocrine disrupting chemicals,” the authors note in the study, published this week in Environmental Health Perspectives, a peer reviewed journal of the U.S. National Institute of Environmental Health Sciences. These endocrine-disrupting chemicals include some pesticides, dioxin and methylmercury, a pollutant from coal-fired power plants and many industrial sources that is commonly found in seafood. The study also flagged a host of other possible factors, […]
Posted in Endocrine Disruption, International | No Comments »
