Archive for the 'Gut Dysbiosis' Category
15
Aug
(Beyond Pesticides, August 15, 2024) Adding to research that has linked insecticide disruption of the gut microbial community to the progression of Parkinson’s Disease (PD) in the brain is a recently published study that further examines the gut-brain mechanism at work. A review by neuroscientist Nabanita Ghosh, PhD in Chemical Research in Toxicology—coauthored by Krishnendu Sinha, PhD, molecular toxicologist and applied pharmacologist, and molecular toxicologist Parames C. Sil, PhD—focuses on how pesticide-induced microbial community alterations specifically drive the initiation of PD and the precise mechanism. The study also explores microbiota changes at different stages of PD progression, offering recent findings.    The researchers derive their data from the examination of PD patients, evaluating the “interaction between pesticides and gut bacteria in PD patients, summarizing how pesticides cause imbalances in gut bacteria, the resulting changes, and their overall effects on the PD prognosis.”  The review “looks at how pesticides and gut bacteria separately influence PD development and progression, highlighting the harmful effects of pesticides and changes in gut bacteria.” The team concludes that pesticide exposure is connected to PD onset through “disturbances in gut function and alterations in intestinal microbiota.” However, the “exact role of microbial factors in this connection remains […]
Posted in Brain Effects, Gut Dysbiosis, Microbiata, Microbiome, Paraquat, Parkinson's, Uncategorized | 1 Comment »
04
Jun
(Beyond Pesticides, June 4, 2024) A study published in the most recent edition of the journal Ecotoxicology and Environmental Safety documents for the first time the presence of the herbicide glyphosate in human sperm. The study looked at 128 French men with an average age of 36 years who tested positive for glyphosate in their blood. Seventy-three out of the 128 men were found to also have glyphosate in their seminal plasma. Not only that, the amount of glyphosate in seminal plasma was nearly four times higher than what was detected in the blood.  Methods The study involved a population of 128 infertile French men from whom seminal and blood plasma samples were collected. The study was conducted at the “Pole SantĂ© LĂ©onard de Vinci” medical center, located centrally near Tours, France. This region is recognized for its urban characteristics as well as being a major agricultural hub, particularly for grain and wine production. The study authors note, “This area reflects the common herbicide exposure in France” and the district ranks third highest in terms of pesticide purchases. While additional qualitative data was collected, only 47 of 128 participants fully completed a questionnaire about their profession, diet (organic or […]
Posted in 2,4-D, aminomethylphosphonic acid (AMPA), Antibiotic, Bayer, behavioral and cognitive effects, Birth defects, Chemicals, Developmental Disorders, Dicamba, Disease/Health Effects, DNA Damage, Endocrine Disruption, Environmental Protection Agency (EPA), Genetic Engineering, Glyphosate, Groundwater, Gut Dysbiosis, Herbicides, Infertility, Inflammatory bowel disease (IBD), IQ Loss, Kidney failure, Lawns/Landscapes, Leukemia, Litigation, Liver Damage, Lymphoma, men's health, Miscarriage, Monsanto, non-Hodgkin's Lymphoma, Oxidative Stress, Pesticide Regulation, Pesticide Residues, PFAS, Reproductive Health, synergistic effects, Uncategorized, World Health Organization | No Comments »
15
May
(Beyond Pesticides, May 15, 2024) A study published recently in the journal Environmental Research finds a significant correlation between exposure to certain pesticides and an elevated risk of inflammatory bowel disease (IBD), a chronic autoimmune condition of the gastrointestinal tract. The study, adding to the body of science on this subject, evaluates self-reported data from licensed pesticide applicators and their spouses exposed to pesticides for over 20 years. In addition, while some of the chemicals found to be most closely associated with incidents of IBD have been banned from use, they are “forever” chemicals that persist in the environment for generations. These findings demonstrate once again the failings of the current regulatory process to identify hazards before they are put into the environment. The study found evidence that exposure to several organochlorine insecticides (dieldrin, DDT, and toxaphene), as well as organophosphate insecticides (parathion, terbufos, and phorate) and herbicides (2,4,5-T, 2,4,5-TP, and metolachlor), is associated with elevated IBD risk. IBD is a generic term for diseases that result in chronic inflammation of the gastrointestinal tract, such as Crohn’s disease and ulcerative colitis. It is estimated that 6.8 million patients globally suffered from IBD in 2017. IBD may result from an imbalance […]
Posted in Agriculture, Cancer, Carbamates, Cardiovascular Disease, Chemical Mixtures, Chemicals, DDT, Dieldrin, Disease/Health Effects, Environmental Justice, Environmental Protection Agency (EPA), Farmworkers, Glyphosate, Gut Dysbiosis, Herbicides, Inflammatory bowel disease (IBD), Iowa, Lindane, Liver Damage, metabolic syndrome, Metolachlor, Microbiata, Microbiome, North Carolina, organochlorines, organophosphate, Parathion, Phorate, soil health, synergistic effects, terbufos, toxaphene, Uncategorized | 1 Comment »
19
Dec
(Beyond Pesticides, December 19, 2023) Last week, farmworker organizations and Beyond Pesticides, represented by the Center for Food Safety, filed a petition with the U.S. Environmental Protection Agency (EPA) urging that the weed killer glyphosate be removed from the market. The petition cites 200 studies, which represent a fraction of the independent scientific literature on the hazards of glyphosate and formulation ingredients of glyphosate products. This action follows previous litigation in 2022 in which a federal court of appeals struck down EPA’s human health assessment, finding that the agency wrongfully dismissed glyphosate’s cancer risk. The farmworker groups petitioning include Farmworker Association of Florida, OrganizaciĂłn en California de Lideres Campesinas, Alianza Nacional de Campesinas, and the Rural Coalition.  Meanwhile, verdicts against glyphosate’s manufacturer, Bayer, continue to pile up with a December jury verdict in Pennsylvania awarding $3.5 million and a November jury in Missouri ordering $1.56 billion to be paid to four plaintiffs. All link their cancer to use of the Roundup. Bayer has lost almost all of the cases filed against it for compensation and punitive damages associated with plaintiffs’ charge that its product (previously manufactured by Monsanto) caused them harm. The petition summarizes its purpose and justification as […]
Posted in Alternatives/Organics, Announcements, Antibiotic Resistance, Antimicrobial, Aquatic Organisms, Bayer, Birth defects, Cancer, Chemicals, Disease/Health Effects, Endocrine Disruption, Environmental Protection Agency (EPA), Farmworkers, Genetic Engineering, Glyphosate, Groundwater, Gut Dysbiosis, Herbicides, Label Claims, Lawns/Landscapes, Litigation, Liver Damage, Microbiata, Microbiome, Monsanto, non-Hodgkin's Lymphoma, Pesticide Efficacy, Pesticide Mixtures, Pesticide Regulation, Pesticide Residues, Pets, polyethoxylated tallowamine, Regenerative, Reproductive Health, soil health, synergistic effects, Uncategorized, Wildlife/Endangered Sp. | No Comments »
12
Dec
(Beyond Pesticides, December 12, 2023) A review published in Nature Reviews Microbiology finds pesticides can disrupt honeybee (Apis mellifera) microbiota (bacteria) in their gut, altering the immune system, metabolism, behavior, and development. Many studies emphasize chemical-driven agricultural systems dependent upon pollinators and products that harm or kill off these sensitive species. Previous studies have linked adverse impacts to bee microbiome to pesticide exposure. Toxic (manufactured poison) pesticides readily contaminate the ecosystem with residues pervasive in food and water commodities. In addition to this study, the scientific literature commonly associates pesticides with human, biotic, and ecosystem harm, as a doubling of toxic effects on invertebrates, like pollinators, has been recorded since 2004. Pollinator declines directly affect the environment, society, and the economy. Many agricultural and nonagricultural plant species will decline or cease to exist without pollinators. In turn, the economy will take a hit, since much of the economy (65%) depends upon the strength of the agricultural sector. As the science shows, pesticides are one of the most significant stressors for pollinators. Additionally, pesticides have a devastating impact on bees and other pollinators and the larger context of what has been called by scientists as the “insect apocalypse.” In a world where habitat loss and fragmentation show no sign […]
Posted in Biodiversity, Gut Dysbiosis, Increased Vulnerability to Diseases from Chemical Exposure, Pesticide Residues, Pollinators, Wildlife/Endangered Sp. | No Comments »
11
Aug
(Beyond Pesticides, August 11, 2023) Reinforcing earlier findings, a systematic review published in Chemosphere finds the popular herbicide glyphosate and its formulations (glyphosate-based formulations-GBF) exhibit five out of the ten key characteristics (KC) of carcinogens (cancer-causing chemicals). Specifically, glyphosate exhibits strong evidence of genotoxicity, epigenetic alterations (heritable changes in gene expression), oxidative stress, chronic inflammation, endocrine disruption, and disturbs gut microbiota implicated in lymphomagenesis (growth and development of lymphoma). Although organizations like the International Agency for Research on Cancer (IARC) designate glyphosate as a probable human carcinogen, and scientific literature supports the findings on these adverse effects purported by glyphosate, the chemical remains on the U.S. market in various formulations. Glyphosate is the most commonly used active ingredient worldwide, appearing in many herbicide formulas, not just Bayer’s (formerly Monsanto) Roundup®. The use of this chemical has been increasing since the inception of crops genetically modified to tolerate glyphosate over two decades ago. The toxic herbicide readily contaminates the ecosystem with residues pervasive in food and water commodities. In addition to this study, literature proves time and time again that glyphosate has an association with cancer development, as well as human, biotic, and ecosystem harm. Therefore, advocates point to the need for national policies to reassess hazards associated with […]
Posted in Cancer, Endocrine Disruption, Epigenetic, Glyphosate, Gut Dysbiosis, Lymphoma, Respiratory Problems | No Comments »
26
Jan
(Beyond Pesticides, January 26, 2023) A study published in Food Safety and Toxicology finds that the widely used fungicide azoxystrobin (AZO), used in food production and turf management, can disrupt the function of the intestinal (colonic) barrier responsible for the absorption of nutrients and defense against harmful substances. This and other similar data are important because the U.S. Environmental Protection Agency (EPA), with its required pesticide testing protocol, says that the chemical has “low acute and chronic toxicity to humans, birds, mammals, and bees,” and speaks to the need for the agency to modernize its registration requirements. [The agency does note that AZO is “is highly toxic to freshwater fish, freshwater invertebrates, and estuarine/marine fish, and very highly toxic to estuarine/marine invertebrates.] AZO is a broad-spectrum chemical used in wheat, barley, oats, rye, soya, cotton, rice, strawberry, peas, beans, onions, and a long list of other vegetables, as well as on lawns and golf courses, on a range of fungal diseases. The intestinal (colonic) barrier prevents the internal environment from damage caused by exogenous toxins to ensure internal homeostasis, impeding incidences of systemic inflammatory response syndrome (SIRS), sepsis, and multiple organ dysfunction syndrome (MODS). The intestines host a group of microorganisms that form […]
Posted in Azoxystrobin, Gut Dysbiosis, Metabolic Disorders, Microbiata, Microbiome | No Comments »
30
Jun
(Beyond Pesticides, June 30, 2020) A review of scientific literature on the toxic effect of environmental contaminants—including pesticides—published in the journal Toxicological Science, “The Impact of Environmental Chemicals on the Gut Microbiome,” associates these chemicals to changes in the gut microbiome and other adverse health implications. The review, by researchers at the University of Illinois, looks at how environmental contaminants adversely effects and reinforce chemical disruption of the gut microbiome. It highlights the importance of evaluating how environmental contaminants, like pesticides, impact body regulation by gut microbiota. The study has significant implications for considerations that should be, but are not currently, a part of pesticide review and registration by the U.S. Environmental Protection Agency (EPA). Gut microbiota plays a crucial role in lifelong digestion, immune, and central nervous system regulation, as wells as other bodily functions. Through the gut biome, pesticide exposure can enhance or exacerbate, the adverse effects of additional environmental toxicants on the body. Since the gut microbiome shapes metabolism, it can mediate some toxic effects of environmental chemicals. However, with prolonged exposure to various environmental contaminants, critical chemical-induced changes may occur in the gut microbes, influencing adverse health outcomes. Karen Chiu, Ph.D., a graduate research fellow at the […]
Posted in Alternatives/Organics, Atrazine, Chemicals, Chlorpyrifos, Disease/Health Effects, Endocrine Disruption, Glyphosate, Gut Dysbiosis, Microbiata, Microbiome, Obesity, Oxidative Stress, phthalates, Uncategorized | No Comments »
