(Beyond Pesticides, May 30, 2008) A recent study has linked the common herbicide atrazine with endocrine disruption in both fish and human cells. Entitled “The Herbicide Atrazine Activates Endocrine Gene Networks via Non-Steroidal NR5A Nuclear Receptors in Fish and Mammalian Cells,” the University of Califonia, San Francisco (UCSF) research examines the reaction of zebrafish to environmentally relevant levels of atrazine, and mirrors the study in human placental cells. The zebrafish, which are particularly sensitive to endocrine disruptors,  are “feminized”  in greater proportion than the unexposed control group. Fish exposed to atrazine for 48 hours at levels found in agricultural runoff produced twice as many female fish as male. “These fish are very sensitive to endocrine disrupting chemicals, so one might think of them as ‘sentinels’ to potential developmental dangers in humans,” said senior author Holly Ingraham, PhD. “These atrazine-sensitive genes are central to normal reproduction and are found in steroid producing tissues. You have to wonder about the long-term effects of exposing the rapidly developing fetus to atrazine or other endocrine disruptors.” In human cell studies, the researchers found that atrazine activates genes involved in hormone signally and steroid synthesis. “Endocrine-related cell types with a capacity for steroid generation appear […]

(Beyond Pesticides, May 29, 2008) A study published in the May issue of Environmental Health Perspectives shows a link between prenatal exposure to the pesticide DDT and poor attention-related skills in early infancy. This study follows in a long line of recent studies associated with the negative health effects of DDT including: diabetes; non-Hodgkin lymphoma; breast cancer; and autism. Despite the fact that DDT was banned in the U.S. in 1972, concentrations of this toxic chemical’s major metabolite, DDE, have remained alarmingly high in many ecosystems, including the waters of Los Angeles County, the arctic, and even U.S. national parks. All studies documenting the health effects of DDT and chemicals in the same family, organochlorines, are particularly important not just for understanding the lingering effects of DDT from days past, but because many countries continue to employ DDT as a method in controlling mosquitoes that transmit malaria, despite its toxicity, weakening efficacy, and availability of safer alternatives. Other organochlorines are still registered for use in the U.S.The study looked at 788 mother-infant pairs who met several criteria, which included living in a town adjacent to a Superfund site in New Bedford, Massachusetts, a location with known organochlorine contamination. Cord blood […]

(Beyond Pesticides, May 27, 2008) A population-based study looking at how genes and environmental factors interact shows that pet shampoos containing insecticides may trigger autism spectrum disorders (ASD), reports New Scientist. The study findings, presented at the International Meeting for Autism Research, show that mothers of children with an ASD are twice as likely to have used an insecticidal pet shampoo during the prenatal and/or postnatal period when compared to mothers of healthy children. The strongest association was during the second trimester of pregnancy. According to the researchers, pet shampoos often contain pyrethrins and previous animal research has found that pyrethrins are designed to target the central nervous system in insects, rodents and other species and can cause death of neurons and compromise the blood-brain barrier in early life.Examining participants in the Childhood Autism Risks from Genetics and the Environment (CHARGE) study, researchers from the University of California, Davis looked at 333 children with ASD and 198 healthy children between the ages of two and five, and their families. In-depth questionnaires and blood and urine samples were collected. Isaac Pessah, Ph.D., a researcher involved in the study and professor in the Department of Molecular Biosciences, College of Veterinary Medicine at […]

(Beyond Pesticides, May 8, 2008) New research shows that melting Antarctic glaciers are releasing once frozen stores of persistent organic chemicals, now banned in many parts of the world. Marine biologist, Heidi Geisz, a Ph.D. student at the Virginia Institute of Marine Science studying the fate and effect of organic contaminants in the Antarctic, has found that DDT concentrations in penguins has remained at the same levels as they were 30 years ago, when DDT was widely used. Arctic animals such as whales, seals and birds have had a significant decline in their DDT levels during the past decades, while the more stationary Antarctic penguins have not. The study, “Melting Glaciers: A Probable Source of DDT to the Antarctic Marine Ecosystem,” published in Environmental Science and Technology (DOI: 10.1021/es702919n), identifies the melting snow and ice as the continued source of total DDT in this southern ecosystem. The release of DDT also means that other persistent organic pollutants (POPs), including PCBs and PBDEs — industrial chemicals that have been linked to health problems in humans, are also being released. “DDT is not the only chemical that these birds are ingesting and it is certainly not the worst,” Ms. Geisz says. Ms. […]

(Beyond Pesticides, May 6, 2008) Pregnant veterinarians who have occupational exposures to pesticides, anesthetic gases or radiation may have twice the risk of miscarriage, according to a new study published in the May 2008 issue of the journal Occupational and Environmental Medicine. The study, “Maternal occupational exposures and risk of spontaneous abortion in veterinary practice,” looked at the experiences of 1197 female veterinarians working in clinical practice, who graduated from Australian veterinary schools between 1960 and 2000, responding to a questionnaire-based survey. There was a twofold increase in the risk of miscarriage in women veterinarians who use pesticides at work. The researchers found that there was also a twofold increase for those exposed to anaesthetic gases for more than an hour a week without using equipment to remove the gas from the air, and an 80 percent greater risk of miscarriage in those who performed more than five x-ray examinations per week compared with those who performed five or less. Veterinarians are often unable to leave the room whilst performing an x-ray because they have to hold the animal being x-rayed in order to restrain it. Adeleh Shirangi, Ph.D., author of the research from the Department of Epidemiology and Public […]

(Beyond Pesticides, April 11, 2008) The United States House of Representatives’ Committee on Oversight and Government Reform released a report last month on the Food and Drug Administration (FDA) failures that lead to the E.coli outbreak in spinach, which peaked in September 2006. When E.coli was discovered in package spinach, critics of organic agriculture and parts of the media were quick to target organic spinach as the source (starting something of a debunking “war”). NBC’s Today Show erroneously blamed organic agriculture (to which Beyond Pesticides responded here). However, the Congressional report lists a variety of failures on the part of FDA to ensure safe handling and packaging of spinach, citing a limited number of inspections and failure to enforce adequate sanitation and processing practices. The major faults found by the committee range from frequency and thorughness of inspections, to lack of enforcement, including: Packaged fresh spinach facilities were inspected only once every 2.4 years, less than half of FDA’s stated goals. FDA observed objectionable conditions during 47% of the packaged fresh spinach inspections [60% of which pertained to facility sanitation]. Despite observing objectionable conditions in packaged fresh spinach facilities, FDA took no meaningful enforcement action. FDA overlooked repeated violations. FDA […]

(Beyond Pesticides, April 10, 2008) Common frogs that live in suburban areas are more likely than their rural counterparts to develop reproductive abnormalities, according to David Skelly, PhD, professor of ecology at the Yale School of Forestry and Environmental Studies. This phenomenon becomes a serious concern as the frog’s mating season begins, leaving researchers to wonder: will frogs be clear on their role in the annual ritual? Research by Dr. Skelly, soon to be published, focuses on the common green frog, Rana clamitans, within the Connecticut River Valley. A total of 233 frogs were collected from various ponds and landscapes with the river valley and among them 13 percent have abnormalities occurring in their reproductive organs. In urban areas, 18 percent of the collected frogs are intersex, and in suburban areas 21 percent. Frogs collected from agricultural areas have the lowest rate of reproductive problems with just 7 percent classified as intersex. According to Dr. Skelly, the more suburban the land cover, the more likely the abnormalities. “This is the first evidence that I think anyone has provided that agriculture is doing anything but pushing those rates higher,” remarked Dr. Skelly of the intersex phenomena. In an attempt to explain […]

(Beyond Pesticides, April 8, 2008) A team of University of Michigan scientists discover interactions between genes and organophosphate exposure cause some forms of motor neuron disease (MND). The study, which appears in the March issue of the American Journal of Human Genetics, shows the mutations in one key gene (neuropathy target esterase, or NTE) that causes a previously unknown type of inherited MND. The scientists also find the mutations caused changes in a protein already known to be involved when people develop neurologic disorders as a result of exposure to toxic organophosphate chemicals commonly used in solvents and insecticides and also as “nerve gas” agents. Motor neuron disease is a rare, devastating illness in which nerve cells that carry brain signals to muscles gradually deteriorate. One form of it is Lou Gehrig’s disease or ALS (amyotrophic lateral sclerosis). For most MND patients, the cause is unknown. Figuring out why these people develop the disease, which causes muscles to weaken, atrophy and cease to function, is an important step in developing therapies to treat or prevent motor neuron disease. Motor neuron disease affects five per 100,000 people. “Our findings support the possibility that toxic organophosphates contribute to motor neuron disease in […]

(Beyond Pesticides, April 2, 2008) A study that analyzed chemical contamination in clothes found that fabrics absorb high concentrations of moth repellents, and retain these concentrations even after prolonged airing. These contaminated fabrics then serve as secondary sources of indoor air pollution once the chemicals are released back into the air. Moth repellents, which contain naphthalene and/or p-dichlorobenzene, as well as camphor, have been recognized as major contributors to indoor air pollution. However, their persistence in the fabrics they are used to protect has been underestimated. The study entitled, “Domestic sampling: Exposure assessment to moth repellent products using ultrasonic extraction and capillary GC-MS,” published in Chemosphere, revealed that once cloths are exposed to moth repellents, whether directly or indirectly, high concentrations of p-dichlorobenzene, naphthalene and camphor are detected even after airing. A regular cotton shirt, for example, placed in a cabinet containing one tablet of moth repellent was found to contain up to 7, 3 and 7.5mg of p-dichlorobenzene, naphthalene and camphor respectively after airing for 1 hour. These concentrations are high when compared with the average exposure to p-dichlorobenzene at about 35 micrograms (μg), and the average indoor exposure from naphthalene at less than 1ppb. While airing did reduce […]

(Beyond Pesticides, April 1, 2008) On March 27, many distinguished environmental health and justice advocates in addition to political leaders gathered in Los Angeles, CA to express their gratitude & praised the efforts of the Los Angeles Unified School District, (2nd largest in the nation) for working cooperatively for a decade with California Safe Schools (CSS), a children’s environmental health organization in creating the most protective pesticide policy for schools in the country. California Safe Schools (CSS) was formed by Robina Suwol in 1998, following an incident with her then 6-year-old son Nicholas, a student at Sherman Oaks Elementary School. Unaware students were present, a school gardener in a hazardous materials suit sprayed the herbicide Princep, creating a cloud of pesticide mist students were forced to walk through in order to reach their classrooms. Later, Nicholas, whose asthma had previously been under control, experienced a life-threatening asthma attack. Ms. Suwol’s initial research on a web site sponsored by Cornell University revealed that a single exposure to Princep could be very dangerous to children, and may cause tremors, convulsions & paralysis, among other symptoms. Further investigation revealed that many chemical pesticides commonly used in schools carry significant risks to growing children […]

(Beyond Pesticides, March 31, 2008) Researchers studying related individuals who share environmental and genetic backgrounds find an association between pesticide use and Parkinson’s disease. The strongest links were between the disorder and use of herbicides and insecticides, such as organochlorines and organophosphates. The study, “Pesticide exposure and risk of Parkinson’s disease: a family-based case-control study,” was published March 28 online in the journal BMC Neurology. The research team from Duke University Medical Center and the University of Miami Miller School of Medicine Morris K. Udall Parkinson Disease Research Center of Excellence recruited 319 patients and over 200 relatives. They used telephone interviews to obtain histories of pesticide exposure, living or working on a farm, and well-water drinking. No association was found between Parkinson’s disease and well-water drinking or living or working on a farm, which are two commonly used proxies for pesticide exposures. Parkinson’s disease is a common neurological disorder affecting about 1 million people in the U.S. The disorder typically develops in later life resulting in symptoms such as tremors and muscle rigidity. Although variations in several genes have been identified that contribute to the disease, these rare genetic defects account for a small proportion of the overall prevalence […]

(Beyond Pesticides, March 28, 2008) Three years ago, Carlos Candelario was born without arms or legs and with spinal and lung deformities, birth defects caused by his mother’s exposure to multiple pesticides while working in Ag-Mart Produce fields during her pregnancy. His parents, Francisca Herrera and Abraham Candelario, sued the company in 2006, and last week’s settlement will provide for Carlos for the rest of his life, pending a judge’s approval. “I am as gratified about this case as any I’ve ever handled,” said attorney Andrew Yaffa. “This child has tremendous needs and needed somebody willing to speak on his behalf. Every medical need will be taken care of as a result of this settlement.” Ag-Mart has a history of state pesticide violations and use of extremely toxic pesticides (although in 2005, the company did agree to discontinue use of chemicals linked to reproductive risks, excepting methyl bromide, which is still in use). The company grows “UglyRipe” heirloom tomatoes and Santa Sweets grape tomatoes in a chemical-intensive operation. Ms. Herrera and Mr. Candelario worked alongside other migrant workers in North Carolina and Florida fields at the time of Ms. Herrera’s exposure. Both Florida and North Carolina have published reports on […]

(Beyond Pesticides, March 25, 2008) According to a new study, Simplifying the Pesticide Risk Equation: The Organic Option, converting the nation’s eight million acres of produce farms to organic would reduce pesticide dietary risks significantly. The report provides the first-ever quantitative estimate of the degree to which pesticide risks from food can be eliminated through adoption of organic farming methods says report author Charles Benbrook, Ph.D., the Organic Center’s chief scientist. Less than three percent of the nation’s cropland produces fruits and vegetables. Yet, according to the report, these crops account for most of the pesticide risks from dietary exposure in domestically produced foods. If converting domestic cropland of organic is coupled with consumers choosing only imported produce that is certified organic, dietary pesticide exposure is reduced by 97 percent.Other findings in the report include: An analysis of the significantly greater pesticide risks linked to consumption of imported conventionally-grown fruits and vegetables, as compared to domestically-grown produce. Rankings of dietary risk levels in select conventionally-grown fruits and vegetables, arranged to help guide consumers seeking to minimize pesticide risks. Suggestions on how to meet dietary guidelines for fruit and vegetable intake in the winter, while also reducing pesticide exposures. An overview […]

(Beyond Pesticides, March 18, 2008) To kick off National Poison Prevention Week on March 17, the U.S. Environmental Protection Agency (EPA) is urging people to “lock up” their pesticides to protect children —stopping far short of advising the public on non-toxic methods of pest management. According to public health advocates, EPA, as a facilitator and apologist for the unnecessary use of highly toxic pesticides that it registers missed an important opportunity during National Poison Prevention Week to alert families with children about integrated management and organic methods that are effective but not reliant on hazardous methods. “With the wide availability of non-toxic methods and products, there is no reason for people to have poisonous pesticides in their homes and risk their children’s exposure,” said Jay Feldman, executive director of Beyond Pesticides. Despite numerous scientific studies that show children carrying a body burden of pesticides used in homes and elevated rates of childhood cancer in households that use pesticides, given children special vulnerability to pesticides, EPA chose to focus on pesticide poisoning of children associated with accidental ingestion. The agency launched the week with the headline “Play It Safe, Prevent Poisonings, Lock Up Pesticides” and the quote, “The U.S. Environmental Protection […]

(Beyond Pesticides, March 13, 2008) Exposure to certain chemicals, including pesticides and nerve agents, explains the high rates of illness in Persian Gulf War Veterans, according to a new study published in the Proceedings of the National Academy of Sciences. Veterans from the 1990-91 conflict have a higher rate of chronic, multi-symptom health problems than either non-deployed personnel or those deployed elsewhere. Symptoms routinely reported by these veterans include fatigue, muscle or joint pain, memory problems, trouble sleeping, rash and breathing problems. Due to the findings, the study author, Beatrice Golomb, M.D., Ph.D., associate professor of medicine at the University of California, San Diego School of Medicine, warns of the potential risk to civilians exposed to pesticides.“Health issues among Gulf War veterans have been a concern for nearly two decades. Now, enough studies have been conducted, and results shared, to be able to say with considerable confidence that there is a link between chemical exposure and chronic, multi-symptom health problems,” said Dr. Golomb. “Furthermore, the same chemicals affecting Gulf War veterans may be involved in similar cases of unexplained, multi-symptom health problems in the general population.”The study synthesized evidence regarding a class of chemicals known as acetylcholinesterase inhibitors (AchEs), including […]

(Beyond Pesticides, March 11, 2008) A Decade of Children’s Health Research: Highlights from EPA’s Science to Achieve Results Program, a ten-year Environmental Protection Agency (EPA) study released March 10, 2008, summarizes important research findings found from $127 million invested in research grants on children’s environmental health in response to an executive order issued in 1997. Executive Order 13045, Protection of Children From Environmental Health Risks and Safety Risks, requires federal agencies to place a high priority on assessing risks to children. EPA, through its Science to Achieve Results (STAR) program, issued more than 60 research grants in response to this order, which in turn, produced more than 1000 scientific journal articles. “Understanding potential environmental health risks to children is important to EPA,” said George Gray, assistant administrator of EPA’s Office of Research and Development. “This research will help us assess and address environmental factors that may affect some of the most vulnerable members of our society.” The report summarizes research from the STAR children’s health program over the past 10 years, highlighting scientific findings in epidemiology, exposure science, genetics, community-based participatory research, interventions, statistics and methods. Some of the major findings of this research include: People metabolize pesticides differently based […]

(Beyond Pesticides, February 26, 2008) The United Farm Workers of America, Beyond Pesticides and others, represented by lawyers from Earthjustice, argued in federal court that the Environmental Protection Agency’s (EPA) decision to allow the use of azinphos-methyl until 2012 was unconscionable. The plaintiffs say EPA did not consider harm to farmworkers and their families, or to rivers, lakes and salmon, and the agency should be forced to reconsider. “There are workers getting sick,” Patti Goldman, a lawyer for Earthjustice, told U.S. District Judge Ricardo S. Martinez. “This isn’t just hypothetical. There are workers being taken out of the field.”The AP reports that Cynthia Morris, a Justice Department lawyer who argued on the agency’s behalf, told the judge that the short-term benefits of allowing growers to keep using AZM for the next several years outweigh the potential harm. She argued that the agency’s decision was reasonable, and failed to meet the “arbitrary and capricious” standard for the judge to undo it.In November 2006, EPA decided that AZM poses unreasonable adverse effects and must be banned but allowed its continued use on fruit crops for six more years — until 2012 — and on nut crops for three more years — until […]

(Beyond Pesticides, February 19, 2008) Common household chemicals and widespread pollutants are changing male reproductive health and impacting sexual function, development and cancer rates of today’s generations and possibly their offspring, according to more than 15 years of research by a Colorado State University expert. For example, one study looking at sperm counts globally from 1940, when chemicals first began to be widely produced, to the 1990s, indicates a 1.15 percent per year decline in sperm counts. These declines may be linked to chemical exposure.Rao Veeramachaneni, BVSc, MScVet, PhD, a biomedical sciences professor in the College of Veterinary Medicine and Biomedical Sciences, has found that chemicals including pesticides, common pollutants in ground water, and chemicals in plastics, make-up and nail polish are on a growing list of culprits causing developmental abnormalities such as impaired sperm quality and impotence. Reproductive health can be compromised if males are exposed at various times in life spanning from in utero up to adulthood.Dr. Veeramachaneni’s findings span the globe and are across species lines, from humans to horses, wildlife to frogs. His research, coupled with the collective findings of other experts in the field, indicates a strong link related to pollutants, and incidence of such […]

(Beyond Pesticides, February 13, 2008) The publication of a federal study undertaken by the Centers for Disease and Control (CDC) has been blocked for more than seven months because it contains “alarming information” of evidence of elevated infant mortality and cancer rates in the region surrounding the Great Lakes.The report entitled, Public Health Implications of Hazardous Substances in the Twenty-Six U.S. Great Lakes Areas of Concern, was commissioned by the International Joint Commission (IJC), an independent organization that advises the U.S. and Canadian governments on the use and quality of boundary waters between the two countries, and compiled by the CDC’s Agency for Toxic Substances and Disease Registry (ATSDR). The report outlines the “areas of concern” in which more than nine million people in major metropolitan areas as Chicago, Cleveland, Detroit, and Milwaukee, face higher health risks from exposure to dioxin, PCBs, pesticides, lead, mercury, or six other hazardous pollutants.Contributors to the report include senior experts from the Environmental Protection Agency, CDC, universities, as well as federal and state researchers. These experts have been reviewing data since 2004 and have found low birth weights, elevated rates of infant mortality and premature births, and elevated death rates from breast cancer, colon […]

(Beyond Pesticides, February 7, 2008) The U.S. Environmental Protection Agency (EPA) has awarded more than $500,000 in federal grant funds to several states and non-profit organizations to be used for programs to educate health care providers and women of childbearing age on environmental health risks.The grants were provided to five states and non-profit organizations in Ohio, Michigan, Oregon, Florida, and Texas, and are to focus on educating women, especially pregnant women, on the hazards of environmental contaminants and hazards to children. Health issues such as exposure to mercury, lead, environmental tobacco smoke, chemicals, pesticides, drinking water contaminants, and indoor and outdoor air contaminants have been especially targeted. These grants are estimated to benefit 3,000 health care providers and 10,000 women of childbearing age.“We’re giving pregnant women information on how to avoid exposure to certain environmental hazards to give children a healthy start to life,” said Dona Deleon, acting director, Office of Children’s Health Protection and Environmental Education. “These grants help the public health community reach women during this important time in their lives.”According to the EPA, pregnancy is a time for joy and celebration, but it is also a time to be especially careful about the environment in which one […]

(Beyond Pesticides, January 31, 2008) A study to be published in the February 2008 issue of Environmental Health Perspectives finds that children who eat a conventional diet of food produced with chemical-intensive practices carry residues of organophosate pesticides that are reduced or eliminated when they switch to an organic diet. The study is entitled “Dietary Intake and Its Contribution to Longitudinal Organophosphorus Pesticide Exposure in Urban/Suburban Children” (Chensheng Lu, Dana B. Barr, Melanie A. Pearson, and Lance A. Waller) and includes authors from Rollins School of Public Health, Emory University, and the National Center for Environmental Health, Centers for Disease Control and Prevention.According to the authors, “The objective of this article is to present the data of assessing young urban/suburban children’s longitudinal exposure to OP [organophosphate] pesticides in a group [of] young children participating in the Children Pesticide Exposure Study (CPES). The results from this study identify not only the predominant source of OP pesticide exposure but also the profile of exposures in children that are vital in formulating the strategies, both from the regulatory policy and personal behavior change perspectives, in reducing children’s exposures to OP pesticides.” The study design included 23 children, male and female, from the Seattle […]

(Beyond Pesticides, January 29, 2008) University of Cambridge scientists say there may be a link between persistent organic pollutants (POPs), including pesticides, and Type 2 Diabetes. The Cambridge scientists are advocating additional research into the little understood links between environmental pollution and adult onset diabetes. In the most recent edition of the journal Lancet, Oliver Jones, Ph.D., and Julian Griffin, Ph.D., highlight the need to research the possible link between persistent organic pollutants (POPs, a group which includes many pesticides) and insulin resistance, which can lead to adult onset diabetes. In their commentary, Dr. Jones and Dr. Griffin cite peer reviewed research including that of D. Lee, et al, which demonstrated a very strong relationship between the levels of POPs in blood, particularly organochlorine compounds, and the risk of type 2 diabetes. “Of course correlation does not automatically imply causation,” says Dr. Jones. “But if there is indeed a link, the health implications could be tremendous. At present there is very limited information. Research into adult onset diabetes currently focuses on genetics and obesity; there has been almost no consideration for the possible influence of environmental factors such as pollution.” Interestingly, in the Lee study an association between obesity and […]

(Beyond Pesticides, January 28, 2008) Reclaiming Our Healthy Future: Political change to protect the next generation, the 26th National Pesticide Forum, will be held March 14-16 at the University of California, Berkeley. Register now to pay the pre-registration rate. Recent speaker additions include Marla Cone, author of Silent Snow and environmental journalist with the Los Angles Times; Paul Saoke, executive director of Physicians for Social Responsibility Kenya; and Ted Schettler MD, science director of the Science and Environmental Health Network. These speakers will be joining a line-up which already includes Arturo Rodriguez (UFW President), Devra Davis, Ph.D. (author and University of Pittsburgh professor of epidemiology) and Tyrone Hayes, Ph.D. (UC Berkeley professor of integrative biology). Also, actress Kaiulani Lee will perform A Sense of Wonder, her one-woman play based on the life and works of Rachel Carson. The conference themes are pesticides and health with a particular focus on  children and workers, a vision for a just and sustainable food system, and creating political change. A tentative schedule of events is now available on the Forum webpage. Marla Cone is one of the nation’s premier environmental journalists. She has 22 years of experience covering environmental issues, including 18 years at […]