(Beyond Pesticides, December 10, 2008) Most families don’t realize that they might be bringing more than holiday cheer into their homes this Christmas season. Families celebrating this holiday season with the time-honored tradition of a Christmas tree can choose to go green and avoid the toxic chemicals that are typically used to grow it. Beyond Pesticides recently launched a Christmas Trees and Pesticides web page to help inform consumers this holiday season. Of the pesticides that the Environmental Protection Agency (EPA) has registered for use on Christmas trees, most are linked to one or more adverse effects, including cancer, hormonal disruption, neurotoxicity, organ damage, reproductive/birth defects, asthma, environmental effects and more. Their use results in exposure to workers, wildlife, and waterways. Beyond Pesticides has compiled a list of 25 pesticides commonly used or recommended for use by state agricultural extension services, including: 2,4-D, bifenthrin, chlorpyrifos, diazinon, esfenvalerate, glyphosate, simazine and more. Oregon, North Carolina, Michigan, Pennsylvania, Wisconsin, Washington, New York, and Virginia are the nation’s top Christmas tree producing states, and together account for more than half of the trees grown in the U.S. The Cooperative Extension Service of North Carolina reports that glyphosate -a pesticide linked to increased risk […]

(Beyond Pesticides, December 5, 2009) On November 10, 2008, the Austrian government released a report of long term research showing genetically engineered (GE) corn fed to mice significantly reduced their fertility over three to four breeding cycles within one generation. Similar effects were found in mice fed GE corn and bred over four generations. The study, “Biological effects of transgenic maize NK603xMON810 fed in long term reproduction studies in mice,” was sponsored by the Austrian Ministry of Health, Families, and Youth, and led by Dr. Jürgen Zentek, Professor of Veterinary Medicine at the University of Vienna. Three series of experiments were done. The first was a multigeneration feeding trial in which the mice were fed and bred for four successive generations, beginning with the parents that were fed the diets from birth. The second was a multi-cycle breeding trial lasting 20 weeks in which breeding pairs of mice were fed beginning one week prior to co-habitation until the end of experiment, and allowed to go through four breeding cycles in the same generation. The third was a life-term trial involving feeding the mice without breeding from conception (via the pregnant mothers) to their eventual death. The researchers report that it […]

(Beyond Pesticides, December 2, 2008) Tributyltin (also known as TBT), a ubiquitous pollutant that has a potent effect on gene activity, could be promoting obesity, according to an article in the December issue of BioScience, the journal of the American Institute of Biological Sciences. The chemical is used in antifouling paints for boats, as a wood and textile preservative, and as a pesticide on high-value food crops, among many other applications. Tributyltin affects sensitive receptors in the cells of animals, from water fleas to humans, at very low concentrations–a thousand times lower than pollutants that are known to interfere with sexual development of wildlife species. Tributyltin and its relatives are highly toxic to mollusks, causing female snails to develop male sexual characteristics, and it bioaccumulates in fish and shellfish. Recent research has found it in deep-sea squids and octopods, and it has been banned for maritime use by an international treaty. The harmful effects of the chemical on the liver and the nervous and immune systems in mammals are well known, but its powerful effects on the cellular components known as retinoid X receptors (RXRs) in a range of species are a recent discovery. When activated, RXRs can migrate into […]

(Beyond Pesticides, December 1, 2008) A new study by researchers at the University of California Los Angeles finds chronic exposure to commonly used dithiocarbamate fungicides, such as ziram, contribute to the development of Parkinson’s disease. According to the study, Ziram Causes Dopaminergic Cell Damage by Inhibiting E1 Ligase of the Proteasome, published in the Journal of Biological Chemistry, researchers screened several pesticides for their ability to interfere with the ubiquitin-proteasome system (UPS). Impaired UPS activity is reported in Parkinson’s disease patients’ brains. The researchers then focused on dithiocarbamate fungicides because they were found to be one of the most potent UPS inhibitors and are commonly used. The researchers discovered the mechanisms by which the UPS is impaired, showing that ziram and structurally related dithiocarbamates inhibit E1 ligase (a protein activating enzyme). Ziram is also found to increase alpha-synuclein (a protein expressed in the central nervous system) levels and selectively damages dopaminergic neurons in vitro. The study also cites unpublished data from a population-based study in central California that is determining pesticide exposure using state application registry, finding that individuals living within 500 meters of where ziram is applied are at three times the increased risk of developing Parkinson’s compared to […]

(Beyond Pesticides, November 18, 2008) At least one in four of the 697,000 U.S. veterans of the 1991 Gulf War suffer from Gulf War illness, a condition caused by exposure to toxic chemicals, including pesticides and a drug administered to protect troops against nerve gas, and no effective treatments have yet been found, a federal panel of scientific experts and veterans concludes in a landmark report released November 17, 2008. The Congressionally-mandated Research Advisory Committee on Gulf War Veterans’ Illnesses presented the report to Secretary of Veterans Affairs James Peake at Veterans Administration (VA) headquarters in Washington, DC. Scientific staff support to the Committee is provided by the Boston University School of Public Health (BUSPH). “The extensive body of scientific research now available consistently indicates that Gulf War illness is real, that it is the result of neurotoxic exposures during Gulf War deployment, and that few veterans have recovered or substantially improved with time,” the report says. The 450-page report brings together for the first time the full range of scientific research and government investigations on Gulf War illness and officially resolves many questions about the condition. The report found that Gulf War illness fundamentally differs from stress-related syndromes described […]

(Beyond Pesticides, November 13, 2008) The Canadian Cancer Society is holding a conference to look at the possibility of advocating for stricter farm pesticide laws. The Cancer Society has been a vocal advocate for the cosmetic pesticide restrictions that have passed in the provinces of Ontario and Quebec as well as many municipalities, but it has not yet taken a stance on the much larger use of agricultural pesticides. Health Canada, the Canadian entity responsible for pesticide regulation insists, as the U.S. Environmental Protection Agency does in the U.S., that registered pesticides do not pose a substantive health risk when used as directed, but mounting scientific evidence shows otherwise. Many of the same chemicals that Canadian provinces have banned for cosmetic use, such as the herbicide 2,4-D, are used in much higher volumes in agriculture than on lawns. Since the Cancer Society is a strong voice in favor of the cosmetic pesticide bans because of the dangers of pesticides, it is logical that they would also be concerned about agricultural pesticide use. In other words, “It’s very hard to argue that the cosmetic use of pesticides poses a public-health risk, including cancer risk, and not examine what is going on […]

(Beyond Pesticides, November 11, 2008) Researchers at the Duke University School of Medicine have linked organophosphate pesticides to the epidemics of obesity and type 2 diabetes. The researchers specifically link neonatal low-dose parathion exposure in rats to disruption of glucose and fat homeostasis. The study, “Exposure of Neonatal Rats to Parathion Elicits Sex-Selective Reprogramming of Metabolism and Alters the Response to a High-Fat Diet in Adulthood,” was published in the November 2008 issue of Environmental Health Perspectives. It follows research by the National Institutes of Health (NIH) that links pesticide exposure to type 2 diabetes using epidemiological data from the Agricultural Health Study. Although most studies of organophosphates focus on their neurotoxicity, there is increasing evidence that these agents may also have a lasting impact on metabolic function. According to authors, obesity and consequent type II diabetes are rising at epidemic rates in the U.S. and many other countries around the world. Two of three U.S. adults are now classified as overweight. There are epidemiologic links between pesticide exposure and diabetes, and the same subpopulations that have the highest rates of obesity””inner-city, low-socioeconomic-status, agricultural populations””are also those that have greater exposure to organophosphates and other pesticides. The researchers chose parathion […]

(Beyond Pesticides, October 22, 2008) Fruits, vegetables and cereals sold throughout the European Union (EU) contain record levels of pesticides, according to an official report to be published later this month by Pesticide Action Network (PAN) Europe. Almost half of fruits, vegetables and cereals are now contaminated with pesticides –a substantial increase on the level seen just five years ago. These findings come at a time when industry and farmers have begun to intensify their opposition to proposed restrictions on toxic pesticides. Five of the pesticides most common in the food chain are classified as carcinogenic, mutagenic, or disruptive to the hormonal system. The findings come just days before politicians in Brussels are set to debate new EU pesticide legislation —-including a proposal to eliminate the most hazardous pesticides from use in food production. But despite evidence of widespread food contamination, efforts to reduce dietary exposure to hazardous pesticides are being fiercely contested by the pesticides industry. “These are the worst pesticide results we’ve ever seen,” said Elliott Cannell, Coordinator of PAN Europe. “A record proportion of fruits and vegetables are contaminated, while 23 pesticides were detected at levels high enough to present an acute risk to public health, according […]

(Beyond Pesticides, October 14, 2008) Exposure to glyphosate or MCPA can more than double one’s risk of developing non-Hodgkin lymphoma (NHL), according to a new epidemiological study published in the October issue of the International Journal of Cancer. The case-control study finds a 2.02 odds ratio (OR) for exposure (two times the chance of contracting the illness) to glyphosate, a 2.81 OR for exposure to MCPA, and a 1.72 OR for exposure to herbicides. According to EPA, glyphosate is the most commonly used pesticide in the U.S. with 103 to 113 million pounds used annually. MCPA is a phenoxyacetic acid pesticide, a family of pesticides that has previously been linked to cancer and includes 2,4-D and mecoprop (MCPP). NHL is a cancer of the immune system. There are several different types of NHL, which are differentiated by the type of immune cell that is cancerous, the characteristics of the cancerous cell, and different genetic mutations of the cancerous cells. Treatment for NHL varies depending on NHL type, patient age, and other existing medical conditions. The incidence of NHL has been increasing over the past several decades. The link between pesticides and cancer has long been a concern. While agriculture has […]

(Beyond Pesticides, October 10, 2008) A study published in the American Journal of Epidemiology [Vol. 167, No. 8] finds women who have used herbicides are twice as likely to have meningioma, a specific kind of brain tumor. The study, “Occupational exposure to pesticides and risk of adult brain tumors,” was conducted by the National Cancer Institute. The authors examined the risk of two types of brain cancer, glioma and meningioma, associated with occupational exposure to insecticides and herbicides in a hospital-based, case-control study of brain cancer. Cases were 462 glioma and 195 meningioma patients diagnosed between 1994 and 1998 in three U.S. hospitals. Controls were 765 patients admitted to the same hospitals for nonmalignant conditions. Occupational histories were collected during personal interviews. Exposure to pesticides was estimated by use of a questionnaire, combined with pesticide measurement data abstracted from published sources. The researchers found no overall link between brain cancer and on-the-job exposure to pesticides or herbicides. However, looking closer at the data, the researchers noticed that women who reported using herbicides had a more than doubled risk for meningioma compared with women who never used herbicides, and there were significant trends of increasing risk with increasing years of herbicide […]

(Beyond Pesticides, September 26, 2008) On September 24, the U.S. Ninth Circuit Court of Appeals dismissed Ivory Coast farmworkers’ claims that they were victims of genocide when pesticide exposure made them sterile. The nearly 700 plaintiffs were exposed to the soil fumigant and nematocide 1,2-Dibromo-3-Chloropropane, or DBCP, while working on Dole Food Company farms in Africa. The original First Amended Complaint was filed on April 6, 2007, and despite the latest setback, the Africans’ attorney, Raphael Metzger, said he would pursue a rehearing. Until 1977, DBCP was widely used in U.S. agriculture, when it was banned for all uses except pineapples. In contrast, DBCP was widely used for fruit production in developing countries in to the 1990s in spite of its U.S. regulatory status. “The manufacturers continued making money on [DBCP] by shipping it to Third World countries where farmworkers were given it to use,” Mr. Metzger said. The suit, Abagninin v. Amvac Chemical Co, was filed under the Alien Torts Statute and contended “that such conduct supports claims under the ATS for genocide and crimes against humanity because the conduct was undertaken with knowledge of DBCP’s effects and pursuant to a State or organizational policy.” The court rejected Abagninin’s […]

(Beyond Pesticides, September 23, 2008) According to the Minnesota Department of Agriculture’s 2007 Water Quality Monitoring Report, released in August 2008, the endocrine disrupting herbicide atrazine is detected in pristine lakes in northern Minnesota far from the agricultural fields where it is applied. Metolachlor, acetochlor and dimethenamid are also frequent contaminants, according to the statewide sampling. The report, which uses data collected by a collaborative program between the U.S. Environmental Protection Agency, the Minnesota Department of Agriculture and the Minnesota Pollution Control Agency, analyzed samples from 55 of the state’s lakes. Atrazine was detected in approximately 87% of the 2007 samples, an increase from 2006. The presence of atrazine in such a large percentage of the lakes, many of which are located in non-agricultural areas of northern Minnesota, suggests widespread atmospheric deposition of this chemical (movement through wind and rain). “To some people, it is a bit of a surprise, but the concentrations are low, very low,” Steven Heiskary, a research scientist with the Minnesota Pollution Control Agency (MPCA) told the Star Tribune. Unfortunately, this is not very reassuring, given the fact that many of the developmental impacts linked to atrazine are seen at very low levels, sometimes at just […]

(Beyond Pesticides, September 22, 2008) A study published in the September issue of Environmental Health Perspectives finds that low-dose, short-term exposure to esfenvalerate, a synthetic pyrethroid pesticide, delays the onset of puberty in rats at doses two times lower than U.S. EPA’s stated no observable effect level (NOEL) of 2.0 mg/kg/day. Synthetic pyrethroids are used for everything from lawn care and household insecticides, to mosquito control and agriculture. There are currently 348 pesticide products registered by the U.S. EPA. The researchers conclude: “Although the exact mechanism of action is unknown at this time, we observed the effects at dosage levels below the NOEL established through chronic dietary exposure studies in rats. The U.S. EPA (1998) http://www.epa.gov/fedrgstr/EPA-PEST/1998/April/Day-29/p11372.htm stated that ”˜There is no evidence of additional sensitivity to young rats or rabbits following pre- or postnatal exposure to esfenvalerate.’ The present study shows that immature female rats exposed to 1.0 mg/kg/day are sensitive to this pesticide, as evidenced by their delay in the onset of puberty. Delayed pubertal onset in humans has been associated with low bone mass density (Ho and Kung 2005), and estrogen is necessary for bone mineral acquisition in both girls and boys (Yilmaz et al. 2005). Importantly, a […]

(Beyond Pesticides, September 19, 2008) Adding to the body of epidemiologic evidence linking pesticides to Parkinson’s Disease (PD), a recent study shows a correlation between 100 PD patients and the use of the pesticide rotenone. The study was conducted by physicians and researchers at The University of Texas Health Science Center at Tyler (UTHSCT) and an East Texas Medical Center physician.The study’s lead author is Aman Dhillon, MD, MS, assistant professor of occupational and environmental medicine at UTHSCT. Rotenone is highly toxic to fish and insects, but mildly toxic to warm-blooded animals and humans. It is made from the roots of tropical plants and is used in home gardens and in fisheries management to remove unwanted fish species, said Jeffrey Levin, MD, MSPH, chair of UTHSCT’s Department of Occupational Health Sciences. Dr. Levin is a co-author of the study, published recently in the peer-reviewed Journal of Agromedicine. A total of 184 people participated in the study: 100 had Parkinson’s disease and 84 did not, though they had other neurological disorders. All were patients of George M. Plotkin, MD, Ph.D., a neurologist with a special interest in Parkinson’s disease. Dr. Plotkin, medical director of the ETMC Movement Disorder Center, treats about […]

(Beyond Pesticides, September 17, 2008) A new study has found a link between total chemical contamination in the bodies of pregnant women and the risk of cryptorchidism in their male babies. Mothers whose babies were born with the defect had the highest concentrations of persistent organic pollutants (POPs), mostly organochlorines like PCB and DDE, in their breast milk. The study, entiltled “Cryptorchidism at birth in Nice area (France) is associated with higher prenatal exposure to PCBs and DDE, as assessed by colostrum concentrations,” and published in the journal Human Reproduction, compared prebirth exposure to chemicals, as measured through their mother’s milk, and the risk of undescended testicles or cryptorchidism, during a three-year period. 164 mother/infant pairs were used and within 3-5 days of delivery, the researchers collected samples of colostrums, or “first milk” from the mother. Colostrum is a form of breast milk that is produced late in pregnancy and immediately after birth before the more creamy milk comes in. It is used as a proxy for what was circulating in the mother’s body and in her fetus during pregnancy. The colostrum was analyzed for three different chemical pollutants including seven polychlorinated biphenyls (PCBs), dichloro-diphenyl-trichloro-ethylene (DDE) and dibutyl phthalate (DBP). […]

(Beyond Pesticides, September 16, 2008) Responding to grassroots pressure highlighting the impact of pests and pesticides on public health, the Boston Public Housing Authority (BHA) is promoting integrated pest management (IPM) through its Healthy Pest Free Housing Initiative Project (HPFHI) in the city’s public housing facilities. The program, which was launched after the Committee for Boston Public Housing, a tenant rights group, began looking into the connection between respiratory health, asthma and housing conditions in 1995, is now proving successful. “The project’s goal is to provide intensive in-home and community-based education designed to change individual and community practices regarding pest control and the use of pesticides,” explains John Kane, IPM coordinator and planner for the Boston Housing Authority (BHA). Mr. Kane says that there has been up to a 75 percent reduction in work orders dealing with pests and a huge increase in the quality of life for the residents. Over 1,000 BHA households in eight developments have received in-home and community-based support and education to encourage integrated pest management practices that focus on prevention and use “least toxic” pesticides only as a last resort. BHA hopes to make the project sustainable and expand their efforts into additional developments. “People […]

(Beyond Pesticides, September 11, 2008) The North Carolina Pesticide Board has begun hearing evidence in a case from 2004 over suspected pesticide violations that were investigated after three female Ag-Mart farmworkers gave birth to babies with severe birth defects. In 2006, the family of Carlos Herrera Candelario, who was born without arms or legs, sued Ag-Mart over illegal pesticide exposure resulting in the boy’s birth defects. The case was settled out of court, with Ag-Mart agreeing to pay the medical expenses of the boy for life and provide him with a permanent income, but insisting that the settlement was not an admission of guilt. The current hearing will look at whether Ag-Mart’s farm manager, Jeff Oxley, is indeed guilty of over 200 violations, including forcing workers into the field too soon after dangerous pesticides were applied. The hearing is significant because the company insists that adequate practices are and have been in place to ensure workers are not exposed to pesticides, even though the testimony of Ag-Mart employees runs counter to this claim. This hearing could do a great deal to elucidate the truth about farmworker pesticide exposure, an important issue for the thousands of workers who plant and harvest […]

(Beyond Pesticides, September 8, 2008) Inorganic arsenic may increase the risk of developing type 2 diabetes, according to a study published in the Journal of the American Medical Association by researchers at the Johns Hopkins Bloomberg School of Public Health. Common sources of inorganic arsenic exposure include dietary exposure, drinking water pollution, and contamination associated with arsenic wood preservatives such as sawdust, smoke, direct contact, and hazardous waste sites. The study found that individuals with diabetes have higher levels of arsenic in the urine compared to individuals without diabetes. Researchers examined randomly selected urine samples taken from 788 U.S. adults 20 years or older that participated in a 2003-2004 National Health and Nutrition Examination Survey. The results were adjusted for diabetes risk factors, including body mass index and for organic arsenic compounds found in seafood. “Our findings suggest that low levels of exposure to inorganic arsenic may play a role in diabetes,” said Ana Navas-Acien, MD, PhD, lead author of the study and assistant professor with the Bloomberg School’s Department of Environmental Health Sciences. “While prospective studies are needed to establish whether this association is causal, these findings add to the existing concerns about the long-term health consequences of low […]

(Beyond Pesticides, August 26, 2008) On August 20, 2008, the 9th U.S. Circuit Court of Appeals reversed a 2006 ruling by the U.S. District Court for the Eastern District of California (Sacramento) that required the state of California to establish limits on air pollution associated with pesticide use. The Appeals Court found that the lower court did not have jurisdiction to impose solutions under the Clean Air Act. According to the plaintiffs represented by the Center for Race, Poverty and the Environment (CPRE), an environmental justice litigation organization based in San Francisco, pesticides are the fourth largest source of smog-forming volatile organic compound (VOC) emissions in California’s San Joaquin Valley. Prior to 2005, the state did not regulate this source of pollution from the politically powerful agriculture industry, even though the state had made a promise to reduce VOC emissions from pesticides by 20% more than a decade earlier in its Ozone State Implementation Plan, a smog clean up plan adopted pursuant to the Clean Air Act. El Comité para el Bienestar de Earlimart and the Association of Irritated Residents, represented by CRPE, filed suit (El Comité para el Bienestar de Earlimart, et al. v. Warmerdam, et al.) in U.S. […]

(Beyond Pesticides, August 25, 2008) A recent study by Spanish researchers has found a connection between an ncreased risk of childhood obesity and exposure to the organochlorine pesticide and contaminant hexachlorobenzene (HCB) before birth. Entitled “Exposure to hexachlorobenzene during pregnancy increases the risk of overweight in children aged 6 years,” the article was published online by Acta Paediatrica at the end of July. Found as a contaminant in the wood preservative pentachlorophenol, widely used in the U.S., HCB is extremely persistent in the environment. The Environmental Protection Agency (EPA) says it “has been listed as a pollutant of concern to EPA’s Great Waters Program due to its persistence in the environment, potential to bioaccumulate, and toxicity to humans and the environment.” Researchers studied 405 infants in Menorca, Spain. They measured persistent organic pollutants (HCB, PCBs, p,p’-DDE, and p,p’-DDT) in their cord blood and then measured each child’s height and weight at 6.5 years of age. “Overweight” was defined as the 85 percentile or higher on the US National Center for Health Statistics/WHO reference body mass index (BMI). They also took into account information about the mothers, such as age, education, socio-economic status, smoking, alcohol use, weight, and diet. All 405 […]

(Beyond Pesticides, August 15, 2008) With a public comment period that ends Monday, August 18, 2008, the U.S. Department of Justice, Disability Rights Section, Civil Rights Division proposes rulemaking that fails to recognize chemical sensitivity (CS) and environmental illnesses as disabilities that may require specific access standards. In a public comment to be submitted next week, Beyond Pesticides urges the Justice Department to specifically include access requirements for those with CS and environmental illnesses in its rulemaking. The organization is urging the public to send comments as well, and invites sign-ons to the Beyond Pesticides’ comment. The comment says, “The proposed rule errs in omitting environmental illness and chemical sensitivity with a justification that people with the illness may have a “sensitivity [that does] not rise to the level needed to constitute a disability.” This statement is false and out of step with environmental medicine which diagnoses CS as a chemical-induced illness from which patients suffer with debilitating effects. Similar to other disabilities, a diagnosis reflects a finding that patients cannot function as a result of exposure to neurotoxic chemicals. Eliminating the chemical exposure substantially increases their ability to function and lead normal lives.” The comment continues, “As an organization […]

(Beyond Pesticides, August 8, 2008) University of California Davis Cancer Center physicians recently released results of research showing that Vietnam War veterans exposed to Agent Orange have greatly increased risks of prostate cancer and even greater risks of getting the most aggressive form of the disease as compared to those who were not exposed. The findings, which appear online now and will be published in the September 15 issue of the journal Cancer, are the first to reliably link the herbicide with this form of cancer by studying a large population of men in their 60s and the prostate-specific antigen (PSA) test to screen for the disease. “While others have linked Agent Orange to cancers such as soft-tissue sarcomas, Hodgkin’s disease and non-Hodgkin’s lymphoma, there is limited evidence so far associating it with prostate cancer,” said Karim Chamie, lead author of the study and resident physician with the UC Davis Department of Urology and the VA Northern California Health Care System. “Here we report on the largest study to date of Vietnam War veterans exposed to Agent Orange and the incidence of prostate cancer.” Chamie also said that, unlike previous studies that were either too small or conducted on men […]

(Beyond Pesticides, August 4, 2008) According to a new Center for Public Integrity investigation, Perils of the New Pesticides, pyrethrins and pyrethroids were responsible for more than 26 percent of all major and moderate human incidents involving pesticides in the United States in 2007, up from just 15 percent in 1998 ”” a 67 percent increase. This is based on an analysis of adverse reaction reports filed with the Environmental Protection Agency by pesticide manufacturers. As a result of the Center’s investigation, the director of the EPA’s Office of Pesticide Programs said the agency would begin a broad study of the human health effects of these chemicals this year. “The alarming rise of pesticide-related incidents attributed to pyrethrin and pyrethroid affiliated products is a serious concern for the millions of households that use them,” said Center Executive Director Bill Buzenberg. “The Center for Public Integrity uncovered this public safety issue through more than a dozen Freedom of Information Act requests and crunching the data. This should be basic public information if the EPA were doing its job.” Data from the American Association of Poison Control Centers reveals a similar trend that supports the EPA data analyzed by the Center. The […]