(Beyond Pesticides, October 25, 2007) In a report it releases every six years, the Centers for Disease Control and Prevention (CDC) issued its School Health Policies and Programs Study (SHPPS) and for the first time considered “the extent to which schools have health-promoting physical school environment policies and programs.” The report’s consideration of environmental health issues suggests a breakthrough in public policy at the federal level. In Part II of the report, in its section on pesticides, the authors cite the work of the American Academy of Pediatrics Committee on Environmental Health, the American Academy of Pediatrics Committee on School Health, the Journal of the American Medical Association, and Beyond Pesticides’ report, The Schooling of State Pesticide Laws. In its introduction the report says: The toll that environmental hazards take on children’s health is not completely understood, nor has it been quantified. Nonetheless, environmental exposure to air pollution, lead in paint and drinking water, tobacco smoke, radon, asbestos, and many pesticides and other chemicals in and around school environments is known to be hazardous to children’s health. The report acknowledges and cites the scientific literature on the special vulnerability of children to environmental hazards during developmental stages of life. The […]

(Beyond Pesticides, October 18, 2007) Antibacterial soaps show no health benefits over plain soaps and, in fact, may render some common antibiotics less effective, says University of Michigan public health professor Allison Aiello, Ph.D. The study, “Consumer Antibacterial Soaps: Effective or Just Risky?” appears in the August edition of Clinical Infectious Diseases. In the first known comprehensive analysis of whether antibacterial soaps containing triclosan work better than plain soaps, Dr. Aiello of the University of Michigan School of Public Health and her team found that washing hands with an antibacterial soap was no more effective in preventing infectious illness than plain soap. Moreover, antibacterial soaps at formulations sold to the public do not remove any more bacteria from the hands during washing than plain soaps. Because of the way triclosan, the main active ingredient in many antibacterial soaps, reacts in the cells, it may cause some bacteria to become resistant to commonly used drugs such as amoxicillin, the researchers say. These changes have not been detected at the population level, but e-coli bacteria bugs adapted in lab experiments showed resistance when exposed to as much as 0.1 percent weight/volume triclosan soap. “What we are saying is that these e-coli could […]

(Beyond Pesticides, October 18, 2007) In a scholarly review written by Theo Colborn, Ph.D. and Lynn Carroll, Ph.D., the authors point to the multigenerational effects of some pesticides that they say demand improved regulation to protect human and environmental health. The review, “Pesticides, Sexual Development, Reproduction, and Fertility: Current Perspective and Future Direction,” appears in the international journal Human and Ecological Risk Assessment (13:5, 1078 — 1110), September, 2007. The study points out a major deficiency in the U.S. Environmental Protection Agency’s regulation of pesticides under current health reviews and risk assessments. The authors call EPA’s pesticide registration system “outmoded” and one that has “almost completely missed the low-dose and endocrine system-mediated effects of pesticides.” The study reviews both epidemiological and laboratory data. In the abstract, the authors state the following: Improvements in chemical analytical technology and non-invasive sampling protocols have made it easier to detect pesticides and their metabolites at very low concentrations in human tissues. Monitoring has revealed that pesticides penetrate both maternal and paternal reproductive tissues and organs, thus providing a pathway for initiating harm to their offspring starting before fertilization throughout gestation and lactation. This article explores the literature that addresses the parental pathway of exposure […]

(Beyond Pesticides, September 24, 2007) Seven representatives wrote to the EPA last Thursday, urging the government agency to act promptly to identify and screen products for dangerous endocrine-disrupting chemicals. The letter asks EPA Administrator Stephen Johnson to provide definite deadlines in the testing and control of endocrine disruptors, which are substances that interfere with the normal functioning of the endocrine system, responsible for hormonal and developmental processes. EPA’s regulation of these substances that mimic or alter natural hormonal processes has been slow and lacks direction to meet set goals promptly, according to the U.S. Representatives. “To date, EPA’s efforts in this area have been characterized by missed deadlines, prolonged delays, and inadequate incorporation of public input,” according to the letter from the House Committee on Oversight and Government Reform, chaired by Rep. Henry Waxman (D-California). Ranking Minority Member on the Committee Tom Davis (R-Virginia); Representatives Elijah Cummings (D-Maryland), Chris Van Hollen (D-Maryland), Wayne Gilchrest (R-Maryland), and Jim Moran (D-Virginia); and Delegate Eleanor Holmes Norton (D-D.C.) also signed the letter to EPA. Advocates say that EPA’s lack of urgency on endocrine disruptors leaves the American population and future generations at risk for adverse health effects from exposure to these substances through […]

(Beyond Pesticides, September 18, 2007) On September 16, 2007, researchers from the National Institute of Environmental Health Sciences presented findings to the European Respiratory Society Annual Congress in Stockholm showing that exposure to several commonly used pesticides increases the risk of asthma in farmers. Pesticide exposure is a “potential risk factor for asthma and respiratory symptoms among farmers,” lead author Dr. Jane A. Hoppin told Reuters Health. “Because grains and animals are more common exposures in agricultural settings, pesticides may be overlooked. Better education and training of farmers and pesticide handlers may help to reduce asthma risk.”The study consisted of 19,704 farmers, 441 of which had asthma. Farmers who have experienced high pesticide exposure were twice as likely to have asthma. Sixteen of the pesticides studied were associated with asthma. Coumaphos, EPTC, lindane, parathion, heptachlor, 2,4,5-TP, DDT, malathion, and phorate had the strongest effect. “This is the first study with sufficient power to evaluate individual pesticides and adult asthma among individuals who routinely apply pesticides,” Dr. Hoppin said. Asthma is a serious chronic disorder of the lungs characterized by recurrent attacks of bronchial constriction, which cause breathlessness, wheezing, and coughing. Asthma is a dangerous, and in some cases life-threatening disease. […]

(Beyond Pesticides, August 28, 2007) In a new study published in the August 2007 issue of the Scandinavian Journal of Work, Environment and Health (Vol. 33, No. 4), researchers from the Central American Institute for Studies on Toxic Substances (IRET) in Costa Rica find parental exposure to pesticides linked to the increased risk of leukemia. IRET researchers, based at the National University of Costa Rica in Heredia, identified cases of childhood leukemia (N=334), in 1995-2000, on the Cancer Registry and the Children’s Hospital. Population controls (N=579) were drawn from the National Birth Registry. Interviews of parents were conducted using conventional and icon-based calendar forms. An exposure model was constructed for 25 pesticides in five time periods. Mothers’ exposures to any pesticides during the year before conception and during the first and second trimesters are associated with the risk [odds ratio (OR) 2.4, 95% confidence interval (95% CI) 1.0-5.9; OR 2.2, 95% CI 2.8-171.5; OR 4.5, 95% CI 1.4-14.7, respectively] and during anytime (OR 2.2, 95% CI 1.0-4.8). An association is found for fathers’ exposures to any pesticides during the second trimester (OR 1.5, 95% CI 1.0-2.3). An increased risk with respect to organophosphates is found for mothers during the first […]

(Beyond Pesticides, August 14, 2007) In an August 8, 2007 Federal Register Notice (72 FR 44510-44511), the Environmental Protection Agency (EPA) announced its decision to not initiate a Special Review for the commonly used herbicide 2,4-D, as well as the related herbicides 2,4-DB and 2,4-DP (dichlorprop). Despite evidence to the contrary, according to the FR notice, “Based on extensive scientific review of many epidemiology and animal studies, EPA find that the weight of the evidence does not support a conclusion that 2,4-D, 2,4-DB and 2,4-DP are likely human carcinogens.” Although a mounting body of evidence links 2,4-D to various cancers, particularly non-Hodgkin’s lymphoma, EPA has been reluctant to classify it as a carcinogen in the face of industry pressure. EPA lists the herbicide in class D for carcinogenicity. Chemicals in this class are considered to have inadequate evidence for carcinogenicity, or not enough data is available. However, the link between 2,4-D and non-Hodgkin’s lymphoma has been demonstrated in the United States, Italy, Canada, Denmark, and Sweden. A 1986 National Cancer Institute (NCI) study found that farmers in Kansas exposed to 2,4-D for 20 or more days per year had a six-fold higher risk of developing non-Hodgkin’s lymphoma than non-farmers. The […]

(Beyond Pesticides, August 8, 2007) For the first time, the World Health Organization (WHO) released a report in July on children’s heightened vulnerability to chemical exposures at different periods of their growth and development. The organization cites over 30% of the global burden of disease in children can be attributed to environmental factors, including pesticides. The report, Principles for Evaluating Health Risks in Children Associated with Exposure to Chemicals, is a new volume of the WHO’s Environmental Health Criteria series. It highlights the fact that for children, the stage of their development when chemical exposure occurs may be just as important as the magnitude of the exposure. In respect to pesticides, the report cites several studies that tie pesticide exposure during key periods of development to neurobehavioral problems, Parkinson’s disease, and immunotoxicity, including respiratory diseases. “Children are not just small adults,” said Dr. Terri Damstra, Ph.D., WHO’s team leader for the Interregional Research Unit, in WHO’s press release. “Children are especially vulnerable and respond differently from adults when exposed to environmental factors, and this response may differ according to the different periods of development they are going through.” Air and water contaminants, pesticides in food, lead in soil, as well […]

(Beyond Pesticides, August 7, 2007) In a study that examines the influence of age of exposure on the magnitude of the association between DDT and breast cancer risk finds that women who were exposed to DDT before the age of 14 are five times more likely to develop breast cancer later in life. In contrast, the study finds exposure after adolescence does not increase risk. The data used in the study targets the age of a woman in 1945 as an indicator for the youngest possible age for a woman to be exposed to DDT, since DDT was first introduced to the U.S. for mosquito control in 1945. The researchers, from the Center for Research on Women’s and Children’s Health, Public Health Institute at Berkeley, California and the Mount Sinai School of Medicine, analyzed blood that had been collected from women between 1959 and 1967 – years during which the use of DDT was at its highest. “DDT and breast cancer in young women: New data on the significance of age at exposure,” published last week in the online edition of the journal Environmental Health Perspectives, is “the first study specifically designed, a priori, to consider whether age at exposure […]

(Beyond Pesticides, July 31, 2007) Preliminary research into birth records and pesticide data reveal that mothers who were within 500 meters of fields sprayed with organochlorine pesticides during their first trimester of pregnancy were six times higher to have children with autism compared to mothers who did not live near the fields. Scientists from the California Department of Public Health conducted the study, which is available online in Environmental Health and Perspectives, entitled, “Maternal Residence Near Agricultural Pesticide Applications and Autism Spectrum Disorders Among Children in the California Central Valley.” The study, initiated to “systemically explore the general hypothesis that residential proximity to agricultural pesticide applications during pregnancy could be associated with autism spectrum disorders in offspring,” found that 28% of the mothers studied who lived near fields in Central Valley, which were sprayed with organochlorines, such as endosulfan and dicofol, have children with autism. However, officials are quick to point out that their findings are preliminary. “We want to emphasize that this is exploratory research,” says Dr. Mark Horton, M.D., director of the California Department of Health. “We have found very preliminary data that there may be an association. We are in no way concluding that there is a […]

(Beyond Pesticides, July 27, 2007) A new study, published in the British Journal of Nutrition, shows that organic dairy and meat products in a mother’s diet improve the nutritional quality of her breast milk – markedly increasing beneficial fatty acids. Specifically, a diet in which 90% or more of dairy and meat products are organic is correlated with measurably higher levels of conjugated linoleic acid (CLA) than in a moderately organic diet or a conventional diet. CLA is a type of fat that is believed to have anti-carcinogenic, atherosclerotic (i.e. ability to prevent hardening of arteries), anti-diabetic and immune-enhancing effects, as well as a favorable influence on body fat composition. For newborns specifically, CLA is believed to especially aid immune system development. “These findings provide scientific support for common sense, by showing that organic foods are healthier,” says Dr. Lukas Rist, Ph.D., who is the lead author of the study and the head of research at the Paracelsus Hospital in Switzerland. The study, “Influence of organic diet on the amount of conjugated linoleic acids in breast milk of lactating women in the Netherlands,” involved 312 breastfeeding women with 1-month old infants from the Netherlands and compared mothers on a strict […]

(Beyond Pesticides, July 16, 2007) In its report released on Father’s Day 2007, “Men, Boys and Environmental Threats,” the Canadian Partnership for Children’s Health and Environment urges greater awareness among parents about environmental risks to boys. “All children are at risk from exposure to environmental hazards, but boys appear to be at greater risk,” said Dr. Lynn Marshall, MD, with the Ontario College of Family Physicians. The report summarizes the evidence about environmental risks to boys, specifically examining cancer, asthma, learning and behavioral disorders, birth defects and testicular dysgenesis syndrome. Below is a summary of the report’s findings. Cancer: Although cancer is rare among all children, more boys are diagnosed with cancer than girls. Among young adults (age 20—44) several cancers are on the rise, including testicular cancer. Concern arises over parents’ exposures before conception or during pregnancy. Childhood cancers are associated with exposures to pesticides, solvents, petroleum products, motor vehicle exhaust, benzene and other pollutants. Much remains unknown. Since cancer involves problems with cell division, it is logical that exposures during times of rapid cell division (especially in the womb) likely pose the greatest risk. Asthma: In the past 20 years there has been a dramatic rise in asthma […]

(Beyond Pesticides, June 12, 2007) More than 10 years after being directed to do so by Congress, the Environmental Protection Agency (EPA) has announced that it will test 73 pesticides for their potential to damage the endocrine system and disrupt the normal functioning of hormones in the body, the agency announced in a press release yesterday. EPA is seeking comments on the draft list of 73 pesticides to be evaluated under the new screening regimen. The 1996 Food Quality Protection Act (FQPA) set a 1999 deadline for EPA to develop a battery of assays with which pesticide manufacturers will be required to screen their products as possible endocrine (hormonal) disrupters, similar to tests required to determine whether chemicals cause cancer, birth defects, genetic mutations, or other problems. EPA has repeatedly pushed back the deadline and despite claims to be “a leader in endocrine disruptor research,” EPA has yet to test a single chemical under the protocol. EPA draft list of 73 pesticide ingredients, including both active and inert ingredients, were chosen based on their relatively high potential for human exposure. According to the press release, priority was given “to pesticide active ingredients where there is the potential for human exposure […]

(Beyond Pesticides, June 6, 2007) The results of a recent study indicate that farm workers and persons exposed to high levels of pesticides have an increased risk of developing brain tumors, especially gliomas – a tumor of the nervous system, commonly found in the brain. The study, “Brain tumours and exposure to pesticides: a case-control study in southwestern France,” published online in the journal Occupational and Environmental Medicine, suggests that not only are occupational pesticide exposure risks high, but indoor domestic uses of pesticides also increase the risk of developing brain tumors. Researchers conducted a population base control study with 221 incident cases of brain tumors and 442 individually matched controls selected from a population in Gironde, France between May 1999 and April 2001.The findings show that farm workers were three times more likely to develop gliomas, while persons treating indoor plants were approximately two and a half times more susceptible. However, the study was unable to identify individual pesticides or families of pesticides associated with this health risk. These findings add to the mounting evidence linking pesticide exposure to adverse human health effects. Recent studies have linked pesticide exposure to the increased likelihood of developing Parkinson’s disease. Other health […]

(Beyond Pesticides, May 31, 2007) Adding to the weight of the evidence tying pesticide use to Parkinson’s disease, a study by University of Aberdeen researchers has found that pesticide exposure increases the likelihood of developing the disease. The researchers also found that the risk factor for developing Parkinson’s increases with high levels of pesticide exposure. The European Commission funded study indicates that both pesticides and traumatic head injury play a causative role in Parkinson’s disease. The researchers found that exposure to low levels of pesticides increases the likelihood of being affected by the disease by 1.09 times compared to those with no reported exposure. Those exposed to high levels of pesticides were 1.39 times more likely to develop the disease. The study is one of the largest conducted to date of genetic, environmental and occupational risk factors for Parkinson’s disease and other degenerative parkinsonian syndromes. The researchers identified 959 cases of parkinsonism, 767 of which are diagnosed with Parkinson’s, and 1,989 control cases in Scotland, Italy, Sweden, Romania and Malta. Data on exposure was self-reported by the subjects. The results further compound previous studies suggesting a link between pesticides and Parkinson’s. Several recent findings have also revealed mechanisms that help […]

(Beyond Pesticides, May 22, 2007) In a study published in the latest issue of Environmental Toxicology and Chemistry, scientists found that seafood products from southern China contain high concentrations of DDT and hexachlorocylohexane (HCH). While banned in China since 1983, humans are being exposed to organochlorine pesticides (OCP) at rates high enough to pose health threats. The study responded to high rates of DDT and HCH found in sediment, water and biota in the Pearl River delta and neighboring coast, where land is being rapidly industrialized, urbanized, and transferred from agriculture to commercial development. Researchers tested 212 seafood products, including shrimp, crabs, and mollusks, from 11 coastal cities for 21 OCPs, including DDT, HCH, heptachlor, dieldrin, and endosulfan. The highest concentrations of DDT were found in four species of shellfish, although concentrations varied widely depending on sampling location. The study reported, “These results suggest that bioaccumulation of DDTs in seafood products was highly species-specific, probably due to different feeding habits and habitats.” By taking a large sample of one indicator species, it also concluded “the coastal region of southern China is probably one of the most DDT-polluted areas in the world.” Researchers also found HCH to be more widely prevalent […]

(Beyond Pesticides, May 15, 2007) According to a study commissioned by Susan G. Komen for the Cure and the Silent Spring Institute, 216 chemicals, many found in urban air and everyday consumer products, cause breast cancer in animal tests. The study, “Environmental Factors in Breast Cancer,” the most comprehensive review to date of scientific research on environmental factors that may increase breast cancer risk, was published in the online version of the American Cancer Society’s journal Cancer on May 14, 2007. The state-of-the-science review collected and assessed existing scientific reports on potential links between specific environmental factors and breast cancer. The researchers synthesized national and international data sources and identified 216 chemicals that cause breast tumors in animals, including ten pesticides. They used the information to create a searchable online database featuring detailed information on the carcinogens. The database, accessible at www.komen.org/environment, is available free of charge. The database includes references to 900 studies, 460 of which are human breast cancer studies that were critically evaluated by the research team. The studies measure breast cancer risk related to body size, physical activity, environmental pollutants, and prospective studies of diet. For each study, bibliographic information, key methods and findings, and a […]

(Beyond Pesticides, May 10, 2007) The risk of non-Hodgkin’s lymphoma is significantly increased with substantial exposure to pesticides, regardless of asthma or atopy history, according to findings from a study published in the May issue of the International Journal of Cancer. This study further strengthens the link between exposure to pesticides and cancer and specifically to lymphoma. “Occupational exposure to pesticides and a personal history of atopy have been widely examined as risk factors for non-Hodgkin’s lymphoma (NHL), a neoplasm arising from cells of the immune system,” writes Claire M. Vajdic, Ph.D., of the University of New South Wales, Australia, and colleagues. “These studies have typically found that exposure to pesticides increases risk of NHL, while asthma, or atopy more generally, has been inconsistently protective.” In an Australian population-based, case-control study, the researchers examined the interaction between occupational pesticide exposure and atopy on the risk of NHL. Included in the study were 694 incident cases and 694 randomly selected controls that were matched to cases by age, sex, and state of residence. Participants completed telephone-administered job-specific questionnaires. Experts used the information collected to determine occupational pesticide exposure. History of atopy (including asthma, hay fever, eczema, and food allergy) was self-reported. […]

(Beyond Pesticides, May 8, 2007) A new study, presented yesterday at the Pediatric Academic Societies’ annual meeting, has found a strong correlation between the month of conception and both likelihood of premature birth and future academic achievement. Researchers found that students conceived in June through August, when statewide pesticide applications are at their highest, clearly scored the lowest on the Indiana Statewide Testing for Educational Progress (ISTEP) examinations. Dr. Paul Winchester, M.D., of the Indiana University School of Medicine, studied over 1.5 million third- through tenth-grade students in Indiana. Dr. Winchester explained the correlation saying, “The fetal brain begins developing soon after conception. The pesticides we use to control pests in fields and our homes and the nitrates we use to fertilize crops and even our lawns are at their highest level in the summer.” The study also monitored levels of pesticide and fertilizer use during the year. He continued, “Exposure to pesticides and nitrates can alter the hormonal milieu of the pregnant mother and the developing fetal brain. While our findings to do not represent absolute proof that pesticides and nitrates contribute to lower ISTEP scores, they strongly support such a hypothesis.” In conjunction with the ISTEP study, the […]

(Beyond Pesticides, April 24, 2007) Three recent studies were presented earlier this month at the Parkinson’s Disease Environmental Research meeting in California strengthening the theory that pesticides increase risk of the disease. The studies clarify how pesticide exposure can lead to the development of Parkinson’s. Two pesticides named in the studies are paraquat and dieldrin, both of which have been linked to Parkinson’s in the past. The three new studies, however, combine information from human and animal studies to show how exposure can lead to onset of the disease. As William Langston, M.D., founder of the Parkinson’s Institute, told Reuters, “All of these pieces really look like they are coming together now.” The first study examined a cohort of 80,000 licensed private pesticide applicators and spouses. Researchers found farm workers exposed to paraquat had twice the expected risk of Parkinson’s. The second and third studies address a protein called alpha-synuclein. The second study shows the protein builds up in rodents exposed to paraquat. The third study connects this protein to Parkinson’s by finding that the protein kills the dopamine-producing brain cells affected by the disease. One common difficulty in tracking pesticide-induced diseases is the amount of time that passes between […]

(Beyond Pesticides, April 12, 2007) A new study has found the proportion of boys born over the past three decades has unexpectedly dropped in both the United States and Japan. In all, more than a quarter of a million boys are missing, compared to what would have been expected had the sex ratio existing in 1970 remained unchanged. The study’s authors hypothesize that the skewed sex ratio may be linked to prenatal exposure to endocrine-disrupting chemicals such as pesticides. Although the researchers do not know why boys are taking a hit, they suspect contributing causes could include widespread exposure to hormone-mimicking pollutants by women during pregnancy and by men before they conceive children. “We hypothesize that the decline in sex ratio in industrial countries may be due, in part, to prenatal exposure to metalloestrogens and other endocrine disrupting chemicals,” the authors note in the study, published this week in Environmental Health Perspectives, a peer reviewed journal of the U.S. National Institute of Environmental Health Sciences. These endocrine-disrupting chemicals include some pesticides, dioxin and methylmercury, a pollutant from coal-fired power plants and many industrial sources that is commonly found in seafood. The study also flagged a host of other possible factors, […]

(Beyond Pesticides, April 10, 2007) Scientists have reported several environmental estrogens can affect the immune system, promoting allergic diseases such as asthma. Researchers have observed this response using pesticides and other environmental contaminants. Focusing on six environmental estrogens (xenoestrogens), researchers were able to reveal how these contaminants affect the immune system. Using doses representative of present human exposures, these estrogen-mimics were tested on human and mouse cells. The observed effect of exposure was both an increase in speed and intensity of immune reactions. Three of the environmental estrogens tested were organochlorine pesticides or metabolites: endosulfan, dieldrin and DDE (DDT metabolite). The other contaminants included nonylphenol, a by-product of plastics manufacturing, and two PCBs. The study reveals that the accelerated and increased level of degranulation of mast cells is the mechanism that causes more severe allergic reactions than would otherwise take place. According to Environmental Health News, mast cells play a vital role in allergic reactions because they are primed by past experience with allergens to release inflammatory agents into the body, which causes an allergic reaction. If the mast cell has been primed to react to a specific allergen, it will degranulate, releasing molecules such as histamine. The more intense […]

(Beyond Pesticides, March 29, 2007) While it seems to allergy-sufferers that symptoms get worse year after year, most figure it’s all in our heads. However, research by Lewis Ziska, Ph.D., a plant physiologist with the USDA Agricultural Research Service’s Crop Systems and Global Change Lab and speaker at the upcoming National Pesticide Forum, shows that common pollen allergens – including the troublesome ragweed pollen – may be getting worse as a result of global climate change. The conventional response to unwanted plants is increased pesticide use, which raises concerns among environmental and public health advocates. According to Dr. Ziska’s research, elevated levels of carbon dioxide (CO2), the top greenhouse gas, and warmer temperatures appear to increase ragweed pollen production. Dr. Ziska’s research uses sealed growth chamber systems to simulate current levels of CO2 (370 parts per million by volume, ppmv) and that projected for the mid-21st century (600 ppmv). The ragweed increased pollen productivity by 131 and 3200% respectively, compared to ragweed grown at pre-industrial CO2 levels (280 ppmv). A recent two-year real-world observational study of ragweed also found that urbanization-induced increases in CO2 and temperature were associated with increased ragweed growth, pollen production and pollen allergenicity, suggesting a probable […]