03
Oct
(Beyond Pesticides, October 3, 2024) The American Academy of Pediatrics published a technical report in September on antimicrobial resistance, which it calls a global public health threat, identifying the health implications of antibiotic use in animal agriculture. The lead authors, both medical doctors from the Department of Pediatrics at Vanderbilt University Medical Center, note the rise in antimicrobial-resistant infections that result in increased morbidity, mortality, and health care costs for not only adults, but infants and children as well. “[A]ll use of antimicrobial agents exerts selective pressure that increases the risk of development of resistance,” the authors state, highlighting the importance of limiting antimicrobial uses. “Antimicrobial resistance is an organism’s ability to survive exposure to an antimicrobial agent that was previously an effective treatment. Resistance traits can be acquired either through new mutations or through transfer of genetic material between organisms,” the authors report. Antimicrobial-resistant pathogens, such as bacteria and viruses, can be transmitted “through the food supply, direct contact with animals, environmental pathways, and contact with infected or colonized humans,” they continue. Use of antimicrobial agents, especially over extended periods of time or with repeated exposure, can cause resistance to not only that agent, but to multiple agents. As […]
Posted in Agriculture, Antibacterial, Antibiotic Resistance, Antimicrobial, Centers for Disease Control and Prevention, Centers for Disease Control and Prevention (CDC), Children, E.coli, Food and Drug Administration (FDA), Fungal Resistance, Livestock, National Organic Standards Board/National Organic Program, Resistance | No Comments »
06
Sep
(Beyond Pesticides, September 6, 2024) A literature review in the Internal Journal of Molecular Sciences provides promising insights into biofungicides as a “sustainable and economically viable alternative” to synthetic fungicides in expanding organic agriculture. The authors note that organic “… is the most sustainable response to current crises of all kinds, as it can better anticipate and prepare for crises and create long-term equity and resilience in food systems.” The authors point out that fungal infections in crops are estimated to account for 20-40% of failures annually, and understanding how to control such agricultural diseases will be crucial to meeting the needs of a growing global population. Organic farmers and land managers note that biological tools can be integrated into practices that work with the ecosystem, rather than be utilized as “substitute” products or controls with practices that ignore soil health and beneficial organisms that enhance biodiversity and provide ecosystem services (see here and here). Conducted by researchers in Mexico, the review examines data on biosynthesis (how plants create their own fungicide, known as secondary metabolites or SMs); the mechanisms of action of secondary metabolites against phytopathogenic (plant-killing) fungi; extraction techniques and biofungicide formulations; the biological activity of plant extracts on phytopathogenic fungi; and […]
Posted in Agriculture, Alternatives/Organics, Antibiotic Resistance, Antimicrobial, biofungicides, Disease/Health Effects, Ecosystem Services, Fungal Resistance, Fungicide, Fungicides, National Organic Standards Board/National Organic Program, NOSB National Organic Standards Board, Organic Foods Production Act OFPA, Pesticide Regulation, Pesticide Residues, soil health, Uncategorized | No Comments »
08
Jan
(Beyond Pesticides, January 8, 2024) Despite successful litigation that stopped the unnecessary use of an antibiotic (streptomycin) in citrus production in December 2023, the court’s reasoning fails to grasp the science behind the biggest emerging threat to U.S. and global health—antibiotic resistance. What is most disturbing and challenging is that the U.S. Environmental Protection Agency (EPA), responsible for applying science in the protection of the public’s health, misled the court on the overwhelming worldwide scientific consensus on the contribution of agricultural antibiotic use to the human death and disability rate linked to antibiotic resistance. On this subject, Beyond Pesticides has written extensively about horizontal gene transfer, which explains the movement of antibiotic resistant bacteria throughout the environment, ultimately making their way to people, as medically necessary drugs become ineffective. As we’ve written, “The human pathogenic organisms themselves do not need to be sprayed by the antibiotic because movement of genes in bacteria is not solely “vertical,” that is from parent to progeny—but can be “horizontal”— from one bacterial species to another.” [Regarding the reliance of the court on EPA’s misrepresentation of the science, the court found, ”EPA emphasized that ‘there is no data that antibiotic use in agriculture leads to […]
Posted in Agriculture, Antibiotic Resistance, Antimicrobial, Environmental Protection Agency (EPA), Fungal Resistance, International, Uncategorized, United Nations | No Comments »
10
May
(Beyond Pesticides, May 10, 2023) Scientists are uncovering more information about a fungal pathogen behind a disease outbreak in Indian hospitals that sickened 10 pre-term infants. According to a study published in mBIO late last month, the yeast pathogen Lodderomyces elongisporus was the causative agent of this outbreak and is rapidly evolving resistance to control measures. There is growing concern globally over the spread of fungal pathogens, with scientists increasingly identifying agriculture as the driver behind pathogenic mutations and resistance. Scientists in Delhi, India were called to investigate an outbreak of L. elongisporus that sickened ten infants with low birthweight in the neonatal intensive care unit (NICU) from September 2021 to February 2022. L. elongisporus is more commonly known for attacking severely immunocompromised adults, including those with heart conditions or a history of intravenous drug use. However, there are an increasing number of reports of fungal infections in neonatal care units. Further, the fungus appears to be spreading globally, with reports of infections in the Middle East, Europe, Australia, and North America. “This yeast is among a growing list of fungi capable of causing severe infections among humans,” said lead study author Jianping Xu, PhD a professor at McMaster University […]
Posted in Environmental Protection Agency (EPA), Fungal Resistance, Fungicides, Resistance, Uncategorized, US Department of Agriculture (USDA) | No Comments »
22
Nov
(Beyond Pesticides, November 22, 2022) Fungus that survive a fungicide application may be able to multiply and thrive, putting plant yields at risk. This finding comes from research recently published by scientists at University of Illinois, focusing on the impact of fungicide use on soybean yields and the disease Septoria brown spot, caused by the fungus Septoria glycines. The research underlines the danger of preventive chemical applications in an attempt to protect yield and shows how precarious pesticide use can be when subject to the complexity seen in field conditions. Scientists began with the intent of analyzing the soybean’s phyllosphere mycobiome, the fungal microbial make-up of the outside of the plant, including all its surfaces above-ground. A field trial was established near Urbana, Illinois, and soybeans plants were separated into four different plots according to their treatment. One group was inoculated with Septoria glycines, another inoculated and sprayed with a fungicide, a third not inoculated yet sprayed with a fungicide, and a final control group neither inoculated nor treated with a fungicide. A range of different analyses were conducted to view changes in the disease development and mycobiome composition over time. Soybean plants that had been inoculated with Septoria showed […]
Posted in Agriculture, fluxapyroxad, Fungal Resistance, Fungicides, Microbiata, Microbiome, pyraclostrobin, Resistance, Uncategorized | No Comments »
06
Apr
(Beyond Pesticides, April 6, 2022) Conventional apples sold at market and sprayed with synthetic fungicides may not only contain drug-resistant fungi, but function as a transmission reservoir and route to spread these dangerous pathogens, finds research published in mBio late last month by a team of researchers from India and Canada. As reports of fungal resistance rise, particularly in hospitals and among the immunocompromised, there is an urgent need to understand and address the root causes of these emerging disease threats. “When we look at human pathogens, we tend to look at what’s immediate to us,” said study coauthor Jianping Xu, PhD. “But we have to look at it more broadly. Everything is connected, the whole system. Fruit is just 1 example.”  Researchers set out their research with the suspicion that stored fruits sprayed with synthetic fungicides were acting as a source and route of transmission for the deadly fungi Candida auris. This yeast is considered an “emerging fungal pathogen” by the U.S. Centers for Disease Control and Prevention (CDC), and has increased its rate of infection significantly since its initial identification in the mid 1990s. The fungi has been found in every continent save Antarctica. It has proven to […]
Posted in Agriculture, Antibiotic Resistance, Centers for Disease Control and Prevention, Fungal Resistance, Resistance, Uncategorized | No Comments »
28
Feb
(Beyond Pesticides, February 28, 2022) When bacteria and fungi become resistant to pesticides, it is a signal that the toxic chemical approach to controlling pathogens does not work. But resistance also poses a direct threat to human health when the pesticide (or a related chemical) is used in human medicine. Tell EPA to cancel all uses of a pesticide when resistance is discovered or predicted to occur. Tell Congress to ensure that EPA protects public health from deadly antifungal and antibiotic resistance. The threat of resistance in bacterial human pathogens has long been widely recognized. Although research sponsored by the Environmental Protection Agency (EPA) recognizes the spread of resistance to antibiotics important in human medicine through horizontal gene transfer in the environment, EPA inaction both on antibiotic and antifungal resistance has become a growing crisis. EPA does recognize the existence of resistance to fungicides. It uses codes produced by the Fungicide Resistance Action Committee in decisions regarding fungicide registration. Although EPA says resistance “may be considered in the risk-benefit decision-making process,” there is no evidence that the agency actually considers the failure of EPA-registered pesticides to control the target organisms in registering pesticides. That failure has a serious impact on […]
Posted in Antibiotic Resistance, Antimicrobial, Environmental Protection Agency (EPA), Fungal Resistance, Uncategorized | No Comments »
23
Feb
(Beyond Pesticides, February 23, 2022) Fungicide use in agriculture is driving the spread of multi-fungicide resistant human pathogens, finds a recent study conducted by scientists at the University of Georgia. While this occurrence has long been an assumption based on the rampant overuse of fungicides in chemical-dependent farming, scientists have now found clear evidence linking the development of widespread fungal resistance to farming practices, rather than health care use. Despite strong evidence that commonly used synthetic pesticides in chemical-intensive farming are driving resistance that threatens human health on a global scale, the U.S. government has not only failed to take action, it has fought against international efforts to slow the crisis, at the behest of the agrichemical industry. Â Scientists focused their research on Aspergillus fumigatus, a common mold that can infect humans and cause aspergillosis. Although some have problems with mild sensitivity to the fungus, virulent infections called invasive aspergillosis can occur in immunocompromised individuals and are on the rise. Cases of invasive aspergillosis increased 3% per annum between 2000 and 2013, and roughly 300,000 worldwide are diagnosed each year. On both farms and in human medical settings, antifungal compounds called azole fungicides are used in attempts to kill […]
Posted in Agriculture, Antibiotic Resistance, Antimicrobial, Fungal Resistance, Fungicides, Resistance, Uncategorized | No Comments »
