(Beyond Pesticides, December 1, 2008) A new study by researchers at the University of California Los Angeles finds chronic exposure to commonly used dithiocarbamate fungicides, such as ziram, contribute to the development of Parkinson’s disease. According to the study, Ziram Causes Dopaminergic Cell Damage by Inhibiting E1 Ligase of the Proteasome, published in the Journal of Biological Chemistry, researchers screened several pesticides for their ability to interfere with the ubiquitin-proteasome system (UPS). Impaired UPS activity is reported in Parkinson’s disease patients’ brains. The researchers then focused on dithiocarbamate fungicides because they were found to be one of the most potent UPS inhibitors and are commonly used. The researchers discovered the mechanisms by which the UPS is impaired, showing that ziram and structurally related dithiocarbamates inhibit E1 ligase (a protein activating enzyme). Ziram is also found to increase alpha-synuclein (a protein expressed in the central nervous system) levels and selectively damages dopaminergic neurons in vitro. The study also cites unpublished data from a population-based study in central California that is determining pesticide exposure using state application registry, finding that individuals living within 500 meters of where ziram is applied are at three times the increased risk of developing Parkinson’s compared to […]

(Beyond Pesticides, November 25, 2008) A new report on U.S. chemical security, which includes two pesticide and 30 bleach manufacturing plants on its list of 101 most dangerous chemical facilities, was released November 19, 2008 by the Washington-based think tank Center for American Progress (CAP). The report, Chemical Security 101: What You Don’t Have Can’t Leak, or Be Blown Up by Terrorists, calls on chemical plants to substitute for their most hazardous chemicals and processes to protect the lives and health of 80 million people living near the 101 worst facilities. The Department of Homeland Security (DHS) and numerous security experts have repeatedly warned that terrorists could use industrial chemicals as improvised weapons of mass destruction. However, according to CAP, current chemical security efforts are inadequate to protect workplaces and communities. “Indeed, temporary standards enacted two years ago (and set to expire in 2009) focus almost entirely on physical security measures, such as adding gates and guards,” say report authors Paul Orum and Reece Rushing. “These measures, however worthy, cannot assure protection against a concerted attack, insider sabotage, or catastrophic release. Nor do they protect communities along chemical delivery routes. More than 90 percent of the 101 most dangerous facilities […]

(Beyond Pesticides, November 18, 2008) At least one in four of the 697,000 U.S. veterans of the 1991 Gulf War suffer from Gulf War illness, a condition caused by exposure to toxic chemicals, including pesticides and a drug administered to protect troops against nerve gas, and no effective treatments have yet been found, a federal panel of scientific experts and veterans concludes in a landmark report released November 17, 2008. The Congressionally-mandated Research Advisory Committee on Gulf War Veterans’ Illnesses presented the report to Secretary of Veterans Affairs James Peake at Veterans Administration (VA) headquarters in Washington, DC. Scientific staff support to the Committee is provided by the Boston University School of Public Health (BUSPH). “The extensive body of scientific research now available consistently indicates that Gulf War illness is real, that it is the result of neurotoxic exposures during Gulf War deployment, and that few veterans have recovered or substantially improved with time,” the report says. The 450-page report brings together for the first time the full range of scientific research and government investigations on Gulf War illness and officially resolves many questions about the condition. The report found that Gulf War illness fundamentally differs from stress-related syndromes described […]

(Beyond Pesticides, November 17, 2008) A toxic soup of the most commonly used pesticides frequently detected in nature can adversely affect the environment and decimate amphibian populations even if the concentration of the individual chemicals are within limits considered safe, according to University of Pittsburgh research published in the online edition of Oecologia. The results of this study build on a nine-year effort to understand potential links between the global decline in amphibians, routine pesticide use, and the possible threat to humans in the future. Amphibians are considered an environmental indicator species because of their unique sensitivity to pollutants. Their demise from pesticide exposure could foreshadow the fate of less sensitive animals, according to study author Dr. Rick Relyea, Ph.D., an associate professor of biological sciences in the University of Pittsburgh’s School of Arts and Sciences. Leopard frogs, in particular, are vulnerable to contamination; once plentiful across North America, their population has declined in recent years as pollution and deforestation has increased. Dr. Relyea exposed gray tree frog and leopard frog tadpoles to small amounts of the ten pesticides that are widely used throughout the world. Dr. Relyea selected five insecticides: carbaryl, chlorpyrifos, diazinon, endosulfan, and malathion; and five herbicides: […]

(Beyond Pesticides, November 13, 2008) The Canadian Cancer Society is holding a conference to look at the possibility of advocating for stricter farm pesticide laws. The Cancer Society has been a vocal advocate for the cosmetic pesticide restrictions that have passed in the provinces of Ontario and Quebec as well as many municipalities, but it has not yet taken a stance on the much larger use of agricultural pesticides. Health Canada, the Canadian entity responsible for pesticide regulation insists, as the U.S. Environmental Protection Agency does in the U.S., that registered pesticides do not pose a substantive health risk when used as directed, but mounting scientific evidence shows otherwise. Many of the same chemicals that Canadian provinces have banned for cosmetic use, such as the herbicide 2,4-D, are used in much higher volumes in agriculture than on lawns. Since the Cancer Society is a strong voice in favor of the cosmetic pesticide bans because of the dangers of pesticides, it is logical that they would also be concerned about agricultural pesticide use. In other words, “It’s very hard to argue that the cosmetic use of pesticides poses a public-health risk, including cancer risk, and not examine what is going on […]

(Beyond Pesticides, November 11, 2008) Researchers at the Duke University School of Medicine have linked organophosphate pesticides to the epidemics of obesity and type 2 diabetes. The researchers specifically link neonatal low-dose parathion exposure in rats to disruption of glucose and fat homeostasis. The study, “Exposure of Neonatal Rats to Parathion Elicits Sex-Selective Reprogramming of Metabolism and Alters the Response to a High-Fat Diet in Adulthood,” was published in the November 2008 issue of Environmental Health Perspectives. It follows research by the National Institutes of Health (NIH) that links pesticide exposure to type 2 diabetes using epidemiological data from the Agricultural Health Study. Although most studies of organophosphates focus on their neurotoxicity, there is increasing evidence that these agents may also have a lasting impact on metabolic function. According to authors, obesity and consequent type II diabetes are rising at epidemic rates in the U.S. and many other countries around the world. Two of three U.S. adults are now classified as overweight. There are epidemiologic links between pesticide exposure and diabetes, and the same subpopulations that have the highest rates of obesity””inner-city, low-socioeconomic-status, agricultural populations””are also those that have greater exposure to organophosphates and other pesticides. The researchers chose parathion […]

(Beyond Pesticides, November 10, 2008) Despite unanimous criticism of its preliminary risk assessment by the environmental community, the U.S. Environmental Protection Agency (EPA), in its completed the Reregistration Eligibility Decision (RED) for the controversial antibacterial triclosan, concludes that all uses, with the exception of the paint use, are eligible for reregistation. Triclosan, which is expected to reach a market value of $930 million by 2009, has exploded on to the marketplace in recent years, growing 5 percent annually, in products from soaps, cosmetic and personal care products, toothbrushes and toothpaste, to plastic toys and textiles. EPA believes that levels of concern for triclosan have not been exceeded even though this pervasive chemical is shown to threaten human health and the environment. The agency has opened a public comment period on the RED which closes on December 29. 2008. Triclosan accumulates in fatty tissue and has been found in breast milk and urine. It has also been linked to hormone disruption and has contaminated most of the nation’s waterways. Its degradates are also known to be persistent, to bioaccumulate and interfere with the hormone system. Triclosan has also been implicated in antibacterial and antibiotic resistance, which has severe consequences in medical […]

(Beyond Pesticides, November 7, 2008) The European Parliament’s environment committee has passed new measures aimed at reducing use and toxicity of pesticides used on crops throughout the European Union (EU). If approved by Parliament at the end of the year, the EU will be on its way to reducing pesticide use by 85 percent by 2013. The measure faces significant backlash from the chemical industry and conventional farmers, but committee members (MEPs) remain firm that the restrictions are both important and possible to do. An official report published last month found record levels of pesticide residues on EU food, giving momentum to pesticide restrictions. One adopted regulation will cause a list of approved “active substances” to be drawn up, according to which pesticides will be registered at a national level. It also allows EU states to be stricter than the allowable list. One amendment says, “Member states may establish any pesticide-free zones they deem necessary in order to safeguard drinking water resources. Such pesticide-free zones may cover the entire Member State.” The second approved measure, passed on to Parliament by EU agricultural ministers in June, bans “certain highly toxic chemicals,” those being endocrine disrupting, genotoxic, carcinogenic or toxic to reproduction. […]

(Beyond Pesticides, November 6, 2008) Agricultural biotech seed and chemical giant Monsanto will acquire Aly Participacoes Ltda., a Brazilian company involved in breeding sugar cane, and has already begun work to develop genetically engineered (GE) Roundup Ready (herbicide resistant) sugarcane. The deal for $290 million comes at the same time grain giant Archer Daniels Midland (ADM) is set to invest $375 million in a joint venture with a Brazilian firm to produce sugarcane-based ethanol. Amidst numerous other concerns with the widespread adoption of GE crops and the proliferation of crops grown for biofuels around the world is the threat of increased pesticide use. Roundup Ready crops, which are genetically engineered to be resistant to Monsanto’s best selling herbicide Roundup (active ingredient glyphosate https://www.beyondpesticides.org/gateway/pesticide/glyphosate.htm) have been a boon to Monsanto’s profits, but not without environmental costs. Currently grown Roundup Ready crops include soy, corn, canola, cotton, and sugar beets. The crops’ resistance to glyphosate enables the use of the herbicide during the growing season without harming the crop itself. Glyphosate is now the number one herbicide in the United States. This has serious implications for public health and the environment, as glyphosate has been linked to cancer, reproductive effects, kidney and […]

(Beyond Pesticides, November 5, 2008) The Environmental Protection Agency (EPA) acknowledged in a recent Federal Register Notice that antimicrobial pesticides in wide use are not adequately tested for their impacts on human health and the environment. Controversy surrounding the impacts of many antimicrobials in the environment has arisen in recent times to due to the prevalence of these chemicals in surface and drinking waters. Antimicrobials are defined by the EPA as “pesticides that are intended to (1) disinfect, sanitize, reduce, or mitigate growth or development of microbiological organisms, or (2) protect inanimate objects from contamination, fouling, or deterioration caused by bacteria, viruses, fungi, protozoa, algae, or slime.” For this proposal, the EPA is using the term antimicrobials to collectively refer to antimicrobial pesticides, antifoulant coatings and paints, and wood preservatives. The use of the controversial antimicrobial, triclosan, in inanimate objects, such as plastic and textiles, would be covered by these regulations, while those personal care products with the very same ingredient would not, since they fall under Food and Drug Administration authority. In the Federal Register last month, EPA, trying to play catch-up with the science while products continue in larger and larger numbers to incorporate the controversial antimicrobials, issues […]

(Beyond Pesticides, November 3, 2008) A new study, Pyrethroid pesticides and their metabolites in vacuum cleaner dust collected from homes and day-care centers (doi:10.1016/j.envres.2008.07.022), by the U.S. Environmental Protection Agency’s (EPA) National Exposure Research Laboratory finds concentrations of 13 synthetic pyrethroids and their degradates in indoor dust collected from homes and childcare centers in North Carolina and Ohio. The study results show the extent to which hazardous pesticides are present in indoor environments and threaten the public’s health, especially the health of children. With 85 vacuum cleaner bags analyzed, permethrin was present in all 85 dust samples, at least one pyrethroid pesticide was found in 69 samples and phenothrin was found in 36 samples. According to the study findings published in the November issue of the journal Environmental Research, the median concentration of permethrin in the samples is 1454ng/g of dust. Excluding permethrin, pyrethroid conectrations are less than or equal to 100ng/g of dust. The majority of the metabolites are present in more than half of the dust samples. This is not the first time researchers have found pesticides in dust in homes. A study published in the International Journal of Hygiene and Environmental Health (208: 193-199) also found that […]

(Beyond Pesticides, October 30, 2008) In an effort to keep its popular yet toxic herbicide 2,4-D on the market, Dow AgroSciences has filed a notice with the Canadian government claiming that Quebec’s ban on cosmetic use of pesticides breaches legal protections under the North American Free Trade Act (NAFTA). The company is likely to pursue compensation from Canada’s federal government under Chapter 11 of NAFTA, which restricts a country from taking measures “tantamount to nationalization or expropriation” of an investment. Despite the threat of legal action, Ontario, which instituted restrictions similar to Quebec’s earlier this year, says it will go ahead with its ban. Public health and environmental advocates have raised concerns that companies are using NAFTA to prevent governments from taking actions to regulate pollution and health threats, and they also warn that the companies’ actions may have a serious public backlash. Chapter 11 of NAFTA is just one of the legal avenues pesticide manufacturers have to make stricter pesticide regulation cumbersome, expensive, and in some cases impossible. For example, 41 states in the U.S. have preemption laws that prohibit municipal authorities from creating pesticide regulation that is more restrictive than the state’s. In a statement that could equally […]

(Beyond Pesticides, October 29, 2008) Two of the largest pineapple growers, Dole and Del Monte, have agreed to stop using endosulfan on pineapples grown on their plantations in the Philippines, beginning next year. The companies have opted not to renew their licenses for the use of this highly toxic chemical but instead will consider a list of alternative pesticides. The Philippines is one of the few countries that still allow the use of endosulfan, though on a restricted basis. Endosulfan is used on pineapple plantations to kill pineapple mites that cause pink disease, a discoloration of canned fruits. This measure to stop the use of endosulfan has been attributed to the recent sinking of the ship MV Princess of the Stars, whose cargo hull contained ten tons of endosulfan. The ship capsized and partially sank on June 21 in a typhoon, killing nearly 800 people onboard. In the wake of that tragedy, leaders in the Philippine government called for an end to endosulfan exemptions granted to foreign companies. Frustrations were raised over the potential for toxic contamination which threatens the health of the Philippine people. 400 packs of endosulfan, each pack weighing 25 kilograms, or a total of 10 metric […]

(Beyond Pesticides, October 27, 2008) Six pesticides that threaten water quality and public health continue to be detected in groundwater samples, according to a new U.S. Geological Survey (USGS) study. Published in the Journal of Environmental Quality, the study evaluates groundwater contaminants from samples taken from over 300 wells across the U.S. Over the years, frequent research has detected pesticides in ground water around the country, including in aquifers used for drinking-water supply. Over the past few decades, the use of some pesticides has been restricted or banned, while new pesticides have been introduced. One goal of the study was to track the retention of various types of contaminants that would be found in the different pesticides used over the years. Original samples were taken from the wells from 1993-1995, and compared with samples taken from 2001-2003. Laboratory analysis was performed using methods that allowed detection of pesticide compounds at concentrations as small as 1,000 times below U.S. EPA drinking-water standards. Of the 80 compounds studied, six were detected in ground water from at least 10 wells during both of those sample periods. The six pesticide compounds detected are the triazine herbicides atrazine, simazine, and prometon; the acetanilide herbicide metolachlor; […]

(Beyond Pesticides, October 24, 2008) A report to be released October 27 by public health groups and leading Maryland health and elder care facilities documents new practices and policies to eliminate toxic pesticide use. The changes reflect a heightened awareness of the need to protect particularly vulnerable populations from serious health risks associated with toxic chemical exposure. A growing body of scientific research links pesticides to Parkinson’s disease, asthma, cancer and other illnesses. “The Maryland health care institutions in the report are to be commended for showing national leadership in adopting non-toxic pest management techniques that protect the health of patients, visitors and staff,” said Jay Feldman, the report’s co-author and executive director of Beyond Pesticides. The report, “Taking Toxics out of Maryland’s Health Care Sector: Transition to Green Pest Management Practices to Protect Health and the Environment,” was co-written by the Maryland Pesticide Network, a statewide coalition advocating safe pest management practices, and Beyond Pesticides, a national environmental and public health group, under their joint “Integrated Pest Management (IPM) in Health Care Facilities Project,” and in collaboration with Maryland Hospitals for a Healthy Environment at the University of Maryland School of Nursing. IPM is an approach to pest management […]

(Beyond Pesticides, October 23, 2008) Researchers in Illinois have developed a genetically modified grape that is resistant to the toxic herbicide 2,4-D. The development is in response to serious losses grape growers in the Midwest have suffered as a result of the surrounding use of 2,4-D on grain crops. While the new variety may mean that Midwest grape growers can continue to grow grapes successfully, it does not address the underlying problem –excessive use of toxic herbicides that are prone to drift thereby contaminating other crops, air and water, and threatening human and environmental health. Herbicide resistant crops were first introduced in 1996 with Roundup Ready soybeans, which were engineered to enable the spraying of Roundup (active ingredient glyphosate) without harming the soybean plants. Since then other Roundup Ready varieties, such as corn, cotton, canola, and sugar beets, have been introduced and are grown in the U.S. and abroad. In a victory for Beyond Pesticides and other environmental groups who see the proliferation of genetically engineered crops as a threat to health, the environment and organic farmers’ livelihoods, a federal court upheld a ban on Roundup Ready alfalfa in September. The widespread adoption of Roundup Ready crops has led to […]

(Beyond Pesticides, October 22, 2008) Fruits, vegetables and cereals sold throughout the European Union (EU) contain record levels of pesticides, according to an official report to be published later this month by Pesticide Action Network (PAN) Europe. Almost half of fruits, vegetables and cereals are now contaminated with pesticides –a substantial increase on the level seen just five years ago. These findings come at a time when industry and farmers have begun to intensify their opposition to proposed restrictions on toxic pesticides. Five of the pesticides most common in the food chain are classified as carcinogenic, mutagenic, or disruptive to the hormonal system. The findings come just days before politicians in Brussels are set to debate new EU pesticide legislation —-including a proposal to eliminate the most hazardous pesticides from use in food production. But despite evidence of widespread food contamination, efforts to reduce dietary exposure to hazardous pesticides are being fiercely contested by the pesticides industry. “These are the worst pesticide results we’ve ever seen,” said Elliott Cannell, Coordinator of PAN Europe. “A record proportion of fruits and vegetables are contaminated, while 23 pesticides were detected at levels high enough to present an acute risk to public health, according […]

(Beyond Pesticides, October 21, 2008) On October 17, 2008, the New York State Department of Environmental Conservation (DEC) announced that the state will be taking action to address the risks posed by total release foggers, also known as “bug bombs,” in the wake of a new federal report detailing hazards and injuries related to the product. DEC will move to classify foggers as a restricted-use product in New York State, meaning that only licensed pesticide applicators, rather than the general public, will be able to obtain them. DEC also says it will explore the need to further limit fogger use and encourage the adoption of better pest management strategies. Total release foggers have caused numerous explosions and acute illnesses due to pesticide exposure. According to a report by the U.S. Centers for Disease Control and Prevention (CDC), there were 123 cases of bug bomb-related illness or injury in New York State (58 in New York City alone) from 2001-06. Information on New York’s incidents are part of a larger study published October 17, 2008 in CDC’s Morbidity and Mortality Weekly Report, which illuminates the hazards of total release foggers using data from several states. The most commonly reported acute health […]

(Beyond Pesticides, October 17, 2008) A study published in the September 15 issue of Environmental Science & Technology has found pyrethroid contamination in 100 percent of urban streams sampled. Synthetic Pyrethroids are one of the most widely used consumer pesticides, but recently they have been scrutinized for their resultant health and environmental effects. California is currently reevaluating certain pyrethroid-containing pesticides as a result of increasingly conclusive research. Entitled “Statewide Investigation of the Role of Pyrethroid Pesticides in Sediment Toxicity in California’s Urban Waterways,” the research included California’s most urbanized regions, as well as the less developed North Coast and Lake Tahoe areas. Thirty creeks in eight regions were selected from 90 screened sites, and bioassays were conducted at two temperatures, 23 and 15 degrees Celsius. Researchers found 25 samples to be toxic at the higher temperature and all 30 at the lower, which is where pyrethroids are more toxic. “Bifenthrin was the pyrethroid of greatest toxicological concern, occurring in all 30 samples,” wrote the team, and the Los Angeles, Central Valley, and San Diego regions showed the most severe contamination. The sampling included analysis for 8 pyrethroids, 30 organochlorine pesticides, and piperonyl butoxide, which helps to make pyrethroids toxic at […]

(Beyond Pesticides, October 16, 2008) Some of America’s most pristine natural places are contaminated with toxic pesticides from illegal marijuana growing operations. Recent busts in the 1800 square mile Sequoia National Park revealed the use of imported and banned herbicides and insecticides in intensive growing sites. Rat poisons, or rodenticides, were also scattered around to kill small animals who might be tempted to nibble a plant. CNN reports that “millions of dollars are spent every year to find and uproot marijuana-growing operations on state and federal lands, but federal officials say no money is budgeted to clean up the environmental mess left behind after helicopters carry off the plants,” and this environmental mess is severe. The extent of marijuana growing on federal lands is unknown, but seven hundred grow sites were discovered in California in 2007-2008. Many of these operations are run by Mexican marijuana growing cartels and the chemicals used are illegally imported from Mexico. It is estimated that 1.5 lbs of fertilizers and pesticides is used for every 11.5 plants. For the five million plants uprooted in California in 2007, this amounts to over 650,000 lbs of fertilizers and pesticides. Agent Patrick Foy of the California Department of […]

(Beyond Pesticides, October 14, 2008) Exposure to glyphosate or MCPA can more than double one’s risk of developing non-Hodgkin lymphoma (NHL), according to a new epidemiological study published in the October issue of the International Journal of Cancer. The case-control study finds a 2.02 odds ratio (OR) for exposure (two times the chance of contracting the illness) to glyphosate, a 2.81 OR for exposure to MCPA, and a 1.72 OR for exposure to herbicides. According to EPA, glyphosate is the most commonly used pesticide in the U.S. with 103 to 113 million pounds used annually. MCPA is a phenoxyacetic acid pesticide, a family of pesticides that has previously been linked to cancer and includes 2,4-D and mecoprop (MCPP). NHL is a cancer of the immune system. There are several different types of NHL, which are differentiated by the type of immune cell that is cancerous, the characteristics of the cancerous cell, and different genetic mutations of the cancerous cells. Treatment for NHL varies depending on NHL type, patient age, and other existing medical conditions. The incidence of NHL has been increasing over the past several decades. The link between pesticides and cancer has long been a concern. While agriculture has […]

(Beyond Pesticides, October 10, 2008) A study published in the American Journal of Epidemiology [Vol. 167, No. 8] finds women who have used herbicides are twice as likely to have meningioma, a specific kind of brain tumor. The study, “Occupational exposure to pesticides and risk of adult brain tumors,” was conducted by the National Cancer Institute. The authors examined the risk of two types of brain cancer, glioma and meningioma, associated with occupational exposure to insecticides and herbicides in a hospital-based, case-control study of brain cancer. Cases were 462 glioma and 195 meningioma patients diagnosed between 1994 and 1998 in three U.S. hospitals. Controls were 765 patients admitted to the same hospitals for nonmalignant conditions. Occupational histories were collected during personal interviews. Exposure to pesticides was estimated by use of a questionnaire, combined with pesticide measurement data abstracted from published sources. The researchers found no overall link between brain cancer and on-the-job exposure to pesticides or herbicides. However, looking closer at the data, the researchers noticed that women who reported using herbicides had a more than doubled risk for meningioma compared with women who never used herbicides, and there were significant trends of increasing risk with increasing years of herbicide […]

(Beyond Pesticides, October 6, 2008) University of Pittsburgh researchers have found that the commonly used insecticide malathion can decimate tadpole populations by altering their food chain. The study, published in the October 1 edition of Ecological Applications, finds that gradual amounts of malathion that were too small to directly kill developing leopard frog tadpoles instead sparked a biological chain of events that deprived them of their primary food source. As a result, nearly half the tadpoles in the experiment did not reach maturity and would have died in nature. The results build on a nine-year effort to investigate whether there is a link between pesticides and the global decline in amphibians, which are considered an environmental indicator species because of their sensitivity to pollutants. According to the researchers, their deaths may foreshadow the poisoning of other less environmentally-sensitivespecies, including humans. According to the U.S. Environmental Protection Agency (EPA), malathion is the most commonly used insecticide in U.S. agriculture and the third most commonly used insecticide in the U.S. home and garden sector. It has been detected in the wetlands where frogs and other amphibians live. The researchers created simulated ponds from 300-gallon outdoor tanks containing wood frog and leopard frog […]