(Beyond Pesticides, January 5, 2022) The use of insecticidal bed nets (IBNs) to prevent mosquito bites in malaria-endemic communities can result in resistance developing in secondary pests like bed bugs, according to research published in Parasites and Vectors. Decreased efficacy against bed bugs and other non-mosquito pests may result in misuse of both mosquito adulticides and bed nets, hampering efforts to stop the spread of malaria and other insect-borne disease. With resistance following a predicable pattern in both disease-transmitting and secondary pests, there is a critical need to embrace safer, nonchemical solutions, including both ecological and structural approaches to pest management. Researchers investigated the efficacy of untreated bed nets along with those treated with the commonly used synthetic pyrethroids deltamethrin and permethrin against both a population of insecticide-susceptible and pyrethroid resistant bed bugs. Insecticidal netting was secured between two glass jars in both an aggregation and blood meal experiment. For the aggregation experiment, fully fed bed bugs were set up to cross through the bed net to reach a darker resting location. With the blood meal experiment, unfed bed bugs were set up to cross the netting to receive a blood meal. Both experiments show the bed nets carrying little […]

(Beyond Pesticides, January 4, 2022) A study published in Environmental Science and Technology finds neonicotinoids (neonics) and their breakdown products (metabolites), like other chemical pesticide compounds, can readily transfer from mother to fetus. The National Health and Nutrition Examination Survey (NHANES) finds U.S. pregnant women experience frequent exposure to environmental pollutants that pose serious health risks to both mother and newborn. Many known pollutants (i.e., heavy metals, polychlorinated biphenyl, and pesticides) are chemicals that can move from the mother to the developing fetus at higher exposure rates. Hence, prenatal exposure to these chemicals may increase the prevalence of birth-related health consequences like natal abnormalities and learning/developmental disabilities. Children are particularly vulnerable to the impacts of pesticide exposure as their developing bodies cannot adequately combat exposure effects. Moreover, a mother’s pesticide exposure can have a stronger association with health disorders than childhood exposure, and a newborn can still encounter pesticides. Therefore, it is essential to understand how pesticides impact the health and well-being of individuals during critical developmental periods. Beyond Pesticides has covered a variety of pregnancy risks from pesticides and other toxic chemicals, including these in just the last three years: pesticides and children’s sleep disorders; prenatal exposures to a multitude of chemicals; insecticides and childhood leukemia; insecticides and Attention Deficit/Hyperactivity Disorder. The study […]

(Beyond Pesticides, December 22, 2022) International health and environmental groups submitted an urgent letter to  the United Nations Food and Agriculture Organization (FAO) late last month demanding “greater transparency and accountability” through termination of the agency’s two-year-old partnership with CropLife International (CLI), a global trade association representing the world’s biggest pesticide manufacturers. Addressed to FAO Deputy Director Beth Bechdol ahead of FAO Council 171 session in Rome and COP15, the letter outlines a unique opportunity for the organization to lead the phaseout of fossil-fuel based food systems and use of agrochemicals while upholding the agency’s responsibility to act in response to conflicts of interest and human rights violations.   The original Letter of Intent (LOI), signed between CLI President and CEO Guilia Di Tommaso and FAO Director-General Qu Dongyu in October 2020, framed the partnership as a means to ensure humanity’s freedom from hunger while advancing Sustainable Development Goals. However, according to PAN Europe Policy Officer Manon Rouby, “While the private sector has been working with FAO for years, this official agreement with CropLife directly threatens FAO’s work on supporting farmers in the transition towards agroecology, while reducing the harms of synthetic pesticides worldwide. With CropLife members being the largest agrichemical […]

(Beyond Pesticide, December 20, 2022) A meta-analysis published in Chemosphere finds prenatal pesticide exposure, or pesticide exposure during pregnancy has a positive association with autism spectrum disorder (ASD) and attention deficit/hyperactive disorder (ADHD). Particularly, exposure to chemical classes organophosphate (OP) and pyrethroid (PYR) insecticides, in addition to the mother’s age during pregnancy (≥30 years old), increased the risk factor of ASD. ADHD risk increases among offspring whose mothers encounter organochlorine pesticides (OCPs) during gestation. The etiology or cause of ASD and ADHD involves the interaction of multiple components, including lifestyle and genetics. However, emerging evidence indicates that environmental contaminants like pesticides (e.g., occupational exposures, air pollution, solvents, dietary residues, etc.) play a role in disease etiology. Pesticide contamination is widespread in all ecosystems, and chemical compounds can accumulate in human tissues resulting in chronic health effects.  ADHD is estimated to affect 8-12% of school-age children worldwide. While it is a complex disease, and genetics may play a role, no specific genes have been identified, and there is increasing evidence that environmental factors like pesticide exposure facilitate the development of the condition. Additionally, U.S. Centers for Disease Control and Prevention (CDC) estimates that 1 in 54 children have been diagnosed with an autism spectrum […]

(Beyond Pesticides, December 13, 2022) Pesticides have a long history associated with hormone (endocrine)-disrupting properties that induce various molecular changes, prompting disease development. Adding to the science, a review published in Environmental Exposure, Biomonitoring and Exposure Assessment highlights how specific estrogen-mimicking pesticides increase the risk of disease, particularly hormone-related cancers among women (i.e., breast, ovarian, endometrial cancer) and men (i.e., testicular, prostate cancer). Like pesticides, endocrine disruptors are xenobiotic (i.e., chemical substances foreign to an organism or ecosystem). Many reports demonstrate that exposure to endocrine-disrupting chemicals can adversely affect human, animal—and thus environmental—health by altering the natural bodily hormones responsible for conventional reproductive, physical, and mental development. Endocrine disruption can lead to several health problems, including hormone-related cancer development (i.e., thyroid, breast, ovarian, prostate, testicular), reproductive dysfunction, and diabetes/obesity that can span generations. Therefore, studies related to pesticides and endocrine disruption help scientists understand the underlying mechanisms that indirectly or directly cause cancer, among other health issues. Pesticides are one of the most potent xeno-estrogenic compounds, as estrogenic strength and environmental half-life exceed those of other xeno-estrogenic compounds. Focusing on organochlorine pesticides (OCs), the study evaluates the chemical effects on the physiological (anatomic) system to increase cancer risk. Using human studies, researchers assessed how estrogen-medicated cancer develops in women and men. […]

(Beyond Pesticides, December 9, 2022) Representatives from more than 195 countries have descended on Montreal for the December 7 start of COP15 — the United Nation’s (UN’s) Conference of the Parties to the Convention on Biological Diversity (CBD). The UN Development Programme sets out the context for this summit: “Despite ongoing efforts, biodiversity is deteriorating worldwide, and this decline is projected to worsen with business-as-usual. The loss of biodiversity comes at a great cost for human well-being and the global economy.” Beyond Pesticides has documented many aspects of this decline in biodiversity, and the implications for ecosystem, human, and planetary health. In this COP15 context, the data points to the importance of broad adoption of organic regenerative / agroecological systems, which can very significantly address the interactive health, biodiversity, and climate crises. Close on the heels of November’s UN COP27 summit on climate, COP15 has commenced, with the goal of adopting a post-2020 Global Biodiversity Framework (CBF) to provide “a strategic vision and a global roadmap for the conservation, protection, restoration, and sustainable management of biodiversity and ecosystems for the next decade.” The first such summit was called the Convention on Biological Diversity and was held in 1993. Out of […]

(Beyond Pesticides, December 7, 2022) A recent study from Australian researchers has investigated pesticide use through an unusual lens — by quantifying the environmental footprints of pesticide use in 82 countries and territories (and eight regions), and then concluding that international trade drives significant pesticide use. The researchers identify the U.S., Brazil, and Spain as the biggest exporters of the “pesticide hazard load” associated with those environmental footprints, and China, the United Kingdom, and Germany as the top three importers. They lay responsibility for this hazard load at the feet of the unsustainable intensification of chemical-intensive agriculture (via synthetic pesticide and fertilizer use during the past 50 years), and ratcheting consumer demand for goods and services. Indeed, they conclude that the latter, in “developed” countries, is responsible for a substantial portion of the pesticide pollution in other countries. The study authors note that previous “efforts to quantify the environmental footprints of global production and consumption have covered a wide range of indicators, including greenhouse gas emissions, water scarcity, biodiversity, nitrogen pollution, acidification, land use, and others, but they have largely missed . . . represent[ing] the environmental pressures exerted by pesticide use.” The researchers set themselves the task of quantifying […]

(Beyond Pesticides, December 6, 2022) Persistent organic pollutants (POPs)—including banned pesticides—present a health risk to humpback whales (Megaptera novaeangliae), according to a study published in Environmental Pollution. Regarding female humpback whales, levels of POPs in blubber are higher in juveniles and subadults than in adults, primarily from the transference of contaminants from the mother to her calf.  Organochlorine compounds (OCs), such as organochlorine pesticides (OCPs) and polychlorinated biphenyls (PCBs), are well-known persistent organic pollutants. The international Stockholm Convention treaty (signed by 152 countries, but not the U.S.) banned these primary pollutants of concern (UNEP, 2009) in 2001 (taking effect in 2004) because of their persistence, toxicity, and adverse effects on environmental and biological health. These pollutants have a global distribution, with evaporation and precipitation facilitating long-range atmospheric transport, deposition, and bioaccumulation of hazardous chemicals in the environment. However, these chemicals can remain in the environment for decades and interact with various current-use pesticides, including organophosphates, neonicotinoids, and pyrethroids. Although various studies demonstrate the volatile, toxic nature of POPs, much less research evaluates the impact POPs have on maternal offloading or transfer of contaminates to offspring and respective health consequences. The globe is currently going through the Holocene Extinction, Earth’s 6th mass extinction, with one […]

(Beyond Pesticides, December 2, 2022) The longest-running — four-decade — investigation comparing organic and conventional grain-cropping approaches in North America is reporting impressive results for organic. Recently announced in the Rodale Institute’s Farming Systems Trial — 40-Year Report are these outcomes: (1) organic systems achieve 3–6 times the profit of conventional production; (2) yields for the organic approach are competitive with those of conventional systems (after a five-year transition period); (3) organic yields during stressful drought periods are 40% higher than conventional yields; (4, 5, and 6) organic systems leach no toxic compounds into nearby waterways (unlike pesticide-intensive conventional farming), use 45% less energy than conventional, and emit 40% less carbon into the atmosphere. Beyond Pesticides reported in 2019 on similar results, from the institute’s 30-year project mark, which have been borne out by another three years of the trials. The current report builds on results from the FST that were shared in the RI’s 2020 white paper, Regenerative Organic Agriculture and Climate Change: A Down-to-Earth Solution to Global Warming,” which integrated the newest research data and offered action steps for consumers, policymakers, farmers, and others. That report asserted that a global switch to a regenerative food system could not […]

(Beyond Pesticides, December 1, 2022) The U.S. Environmental Protection Agency (EPA) must put measures in place to protect endangered species from the hazardous insecticide cyantraniliprole before September 2023. The requirements stems from a recent federal appeals court ruling that found EPA in violation of its statutory obligations under the Endangered Species Act (ESA). The agency originally lost its legal case on this chemical in 2017, but has since done nothing to fulfill the initial court order, necessitating further litigation by conservation groups. “It’s outrageous that the EPA is thumbing its nose at a federal court order even as cyantraniliprole wreaks havoc on our most endangered wildlife,” said Jonathan Evans, environmental health legal director at the Center for Biological Diversity. “The EPA has acknowledged that this pesticide is incredibly toxic to bees and other invertebrates, but the agency is so accustomed to putting the profits of the pesticide industry ahead of its duty to protect human health and our environment that for years it simply ignored a direct court order.” Cyantraniliprole is a systemic insecticide registered for use in 2014. It presents similar risks to pollinators and wildlife as other widely used systemics, such as the neonicotinoid class of chemicals. Its […]

(Beyond Pesticides, November 29, 2022) Based on new international research adding weight to previous research on falling sperm counts, it is critical that environmental agencies address this and other problems related to endocrine disruption. The study by Levine et al. finds that the drop in sperm count—a drop of 51.6% from 1973 through 2018—is global and that the rate of decline is accelerating. Tell EPA and Congress that pesticide use cannot continue without findings of no endocrine disruption.  The documented (average) drop in sperm counts is approaching the level at which the ability to cause a pregnancy begins to plummet dramatically. The reduction in male fertility may have profound psychological and social impacts, including anxiety, low self-esteem, and depression. These psychological problems have health impacts of their own. Equally serious are connections of anxiety and depression with violent behavior and suicide. Compounding the problem is the fact that men are unlikely to seek fertility-related social support. The drop in sperm counts is just one example of endocrine disruption largely due to exposure to toxic chemicals. The endocrine system consists of a set of glands (thyroid, gonads, adrenal and pituitary) and the hormones they produce (thyroxine, estrogen, testosterone, and adrenaline), which […]

(Beyond Pesticides, November 25, 2022) A study published in Chemosphere adds to the growing body of research demonstrating the endocrine (hormone) disrupting effects of glyphosate play in breast cancer development. Exposure to the herbicide glyphosate and other glyphosate-based herbicides (GBHs) at high concentrations mimics the estrogen-like cellular effects of 17β-estradiol (E2), altering binding activity to estrogen receptor α (ERα) sites, thus causing fundamental changes in breast cancer cell proliferation (abundance).  Glyphosate is the most commonly used active ingredient worldwide, appearing in many herbicide formulas, not just Bayer’s (formerly Monsanto) Roundup®. The use of this chemical has been increasing since the inception of crops genetically modified to tolerate glyphosate over two decades ago. The toxic herbicide readily contaminates the ecosystem with residues pervasive in food and water commodities. In addition to this study, literature proves time and time again that glyphosate has an association with cancer development, as well as human, biotic, and ecosystem harm. Therefore, advocates point to the need for national policies to reassess hazards associated with disease development and diagnosis upon exposure to chemical pollutants. The researchers note, “The results obtained in this study are of toxicological relevance since they indicate that glyphosate could be a potential endocrine disruptor in the mammalian system. Additionally, […]

(Beyond Pesticides, November 24, 2021) On Thanksgiving, thank you for being a part of Beyond Pesticides and sharing and contributing to the vision necessary to protect the web and the fragility of life. We believe that there is no time like Thanksgiving to think about how we can more effectively join together as families and communities across divisions and different points of view to find a common purpose in protecting the health of the environment and all that inhabit it. Unfortunately, a host of pesticides, genetically engineered materials, and others in conventional Thanksgiving foods impact human health and threaten the environment. With far too many adverse health and ecological effects associated with toxic chemicals, organic practices are viable solutions to mitigate pesticide contamination and subsequent exposure. Read on as we consider the range of challenges we must confront and the solutions that can bring us all together. Additionally, you can help Beyond Pesticides in educating and building a movement that will bring long-needed protection to humans, animals, and the entire environment by attending the third seminar on November 29 on Climate during the 2022 National Forum Series, Health, Biodiversity, and Climate: A Path for a Livable Future. The National Forum […]

(Beyond Pesticides, November 22, 2022) Fungus that survive a fungicide application may be able to multiply and thrive, putting plant yields at risk. This finding comes from research recently published by scientists at University of Illinois, focusing on the impact of fungicide use on soybean yields and the disease Septoria brown spot, caused by the fungus Septoria glycines. The research underlines the danger of preventive chemical applications in an attempt to protect yield and shows how precarious pesticide use can be when subject to the complexity seen in field conditions. Scientists began with the intent of analyzing the soybean’s phyllosphere mycobiome, the fungal microbial make-up of the outside of the plant, including all its surfaces above-ground. A field trial was established near Urbana, Illinois, and soybeans plants were separated into four different plots according to their treatment. One group was inoculated with Septoria glycines, another inoculated and sprayed with a fungicide, a third not inoculated yet sprayed with a fungicide, and a final control group neither inoculated nor treated with a fungicide. A range of different analyses were conducted to view changes in the disease development and mycobiome composition over time. Soybean plants that had been inoculated with Septoria showed […]

(Beyond Pesticides, November 21, 2022) Once again, the Environmental Protection Agency (EPA) has registered a new pesticide without performing a thorough review of its impacts on biodiversity as well as threatened and endangered species. Inpyrfluxam was registered in 2020 and only after being sued by the Center for Biological Diversity for failure to comply with the Endangered Species Act (ESA) did EPA commit to completing draft effects determinations by Fall 2022. Once again, EPA’s draft biological evaluation is incomplete and inadequate. EPA is accepting comments on its draft biological evaluation at Regulations.gov.  Tell EPA and Congress that Pesticide Registrations Require Complete Science. The Review of Inpyrfluxam is Incomplete and Inadequate.  The agency’s draft effects assessment is flawed and incomplete. We share the details because it shows that EPA is out of step with the science and its regulatory responsibility when it comes a thorough review for ecosystem effects of pesticides.   The agency used fish early life stage (ELS) tests to estimate chronic fish toxicity. This is inappropriate. The fish ELS is a sub-chronic test of sensitive life stages. Although it is often used as a surrogate or predictor of chronic toxicity, it does not adequately address potential adverse effects on reproduction or transfer of the test chemical to eggs/offspring […]

(Beyond Pesticides, November 18, 2022) A new meta-analysis, from researchers at Mount Sinai Medical Center, Hebrew University of Jerusalem, and the University of Copenhagen, among others, finds that the drop in global sperm count is accelerating and the problem has become global. The study shows that sperm count (until this study measured largely in North America, Europe, and Australia) has dropped by 51.6% from 1973 through 2018, and that the rate of decline is gaining speed worldwide.  A primary culprit, among a plexus of factors, is widespread exposure to toxic chemicals, including pesticides, in the environment. Beyond the implications for individuals and families, this global decline in sperm counts has the potential for population-level impacts and, according to Dr. Shanna Swan, an expert environmental–reproductive epidemiologist, could mean that “in the coming decades, large swaths of the global population of men could be subfertile or infertile.” Beyond Pesticides has long highlighted the relationship between reproductive anomalies and toxic pesticides, particularly the role of endocrine-disrupting (ED) compounds. Most recently, we covered a meta-study on pesticides and fertility that “finds exposure associated with lower semen quality, DNA fragmentation, and chromosomal abnormalities.” The new study is covered in Environmental Health News (EHN). From 1972 […]

(Beyond Pesticides, November 17, 2022) A report published in Toxicology and Applied Pharmacology finds organophosphate (OP) insecticides and the coronavirus (SARS-CoV-2/Covid-19) illicit similar damage to the heart and co-occurring exposure to both can escalate cardiac (heart) injury. Previous research suggests OPs may increase the ability of SARS-CoV-2 to cause COVID-19, especially among vulnerable individuals with underlying medical conditions. OPs have a wide range of biological uses—from insecticides to flame retardants—that make these chemicals ubiquitous, significantly contributing to ecosystem contamination. These compounds have a global distribution, with evaporation and precipitation facilitating long-range atmospheric transport, deposition, and bioaccumulation of hazardous chemicals in the environment. OPs are highly toxic, originating from the same compounds as World War II nerve agents, and residues are consistently present in human and animal blood, urine, tissues, and milk. Moreover, OPs are one of the leading causes of poisoning globally. Therefore, it is vital to understand how OP exposure will impact human health in conjunction with other immunologically compromising diseases like COVID-19. Cardiovascular diseases are among the leading causes of death globally. Additionally, heart conditions are one leading cause of disability in the U.S., as research demonstrates environmental pollutant exposure can increase the risk of developing cardiovascular disease, including stroke, heart attack, heart failure, atrial fibrillation, and cardiac […]

(Beyond Pesticides, November 11, 2022) A paper published in Trends in Ecology & Evolution in late October sounds an unnerving alarm about the globally ubiquitous use of herbicides and the ecological destruction being caused. It asserts that widespread environmental contamination with these herbicide compounds is influencing soil, plant, and animal microbiomes in ways that are not only not well understood, but also, can have significant impacts on the functioning of organisms and their ecosystems — with evolutionary implications. Impacts of herbicides on microbiota in soils include, for example, those on nutrient cycling, and altered organism and plant performance, which can affect pollination and animal consumption of plants. This research reinforces what Beyond Pesticides wrote in covering a 2021 study: “The popular herbicide glyphosate negatively affects microbial communities, indirectly influencing plant, animal, and human health. Exposure to sublethal concentrations of glyphosate shifts microbial community composition, destroying beneficial microorganisms while preserving pathogenic organisms.” Herbicides are a category of pesticide used to control weeds in agriculture and commercial forests, on managed landscapes, byways, gardens, and lawns, and directly on surface waters to control aquatic weeds. They are designed to kill “target” plant species considered undesirable in any of those circumstances. Herbicide use has exploded […]

(Beyond Pesticides, November 9, 2022) A team of Dutch researchers has developed an artificial predator dubbed the RobotFalcon that can quickly and successfully scare bird flocks away from fields, providing a new practical, ethical tool to deter bird strikes near airports. Although it sounds like a conspiracy theory, in the skies above Workum, The Netherlands, for a period of time, some of the birds were not real. Current data indicate there are over 17,000 wildlife strikes to aircraft each year in the U.S., costing an estimated $500 million in economic losses, yet these problems are ongoing despite the U.S. Department of Agriculture’s Wildlife Services program killing hundreds of thousands of birds in and around airports each year through a range of lethal means, including the use of guns and pesticides. As a result, new management approaches that focus on effective, nonlethal alternatives to the use of toxic chemicals are urgently needed. Scientists began their research with the understanding that most bird deterrent methods “suffer from some degree of habituation: after repeated exposure, birds respond less.”  While habitation can be reduced through natural threats, the authors note that approaches like falconry are lethal and can be prohibitively expensive and difficult to […]

(Beyond Pesticides, November 8, 2022) Glyphosate weed killers induce antibiotic resistance in deadly hospital-acquired bacteria, according to a new study published late last month in the journal Scientific Reports. This is the latest finding connecting commonly used herbicides to the rise of antibiotic resistant bacteria, with prior research showing glyphosate, 2,4-D, and dicamba able to create resistance in Salmonella and E. coli. While federal regulatory agencies continue ignore the role of pesticides in the development of antibiotic resistance, it is critical for states and localities to take action to protect their most vulnerable both from toxic exposure to these herbicides and the multitude of indirect effects caused by their use. This is all happening as antibiotic resistance is rising to dangerously high levels in all parts of the world, according to the World Health Organization. In the May 1, 2022 issues of the Bulletin of the World Health Organization, Samira Choudhury, PhD, et al. writes, “Often referred to as the silent pandemic, antimicrobial resistance claims the lives of over 700,000 people annually.” The authors continue, “A study suggests that if no actions are taken, antimicrobial resistance will cause 10 million deaths per year by 2050 and an economic impact of […]

(Beyond Pesticides, November 3, 2022) In a fight against global warming, environmental groups Center for Biological Diversity (CBD) and Californians for Pesticide Reform (CPR) filed a formal legal petition in October 2022 urging the California Air Resources Board (CARB) to phase out the use of sulfuryl fluoride insecticides. Sulfuryl fluoride is a fluoride compound with various adverse health effects, including cancer, endocrine disruption, neurotoxicity (reduced IQ), and reproductive damage. CARB added sulfuryl fluoride to its list of “short-lived climate pollutants,” being the only state to do so since 1990. However, California does not include sulfuryl fluoride in the list of GHG emissions to reduce by 2020 as researchers were unaware the chemical was a greenhouse gas (GHG) until 2008. These termite and food use insecticides are 4,800 times more potent GHG than carbon dioxide at trapping carbon in the atmosphere. Furthermore, sulfuryl fluoride has high global warming potential and can remain in the atmosphere for more than 36 years. The case of sulfuryl fluoride presents an all too familiar pattern of widespread chemical use without proper knowledge of health and environmental effects before implementation and a failure to take regulatory action on known hazards after allowed in commerce. Therefore, CBD’s […]

(Beyond Pesticides, October 28, 2022) The Maine Congressional delegation — Senators Collins (R) and Angus King (I), and Representatives Chellie Pingree (D) and Jared Golden (D) — along with New Hampshire Senator Jeanne Shaheen (D), have introduced a bipartisan and bicameral bill — the Relief for Farmers Hit with PFAS Act — to help farmers who have been impacted by the scourge of PFAS (perfluoroalkyl and polyfluoroalkyl substances) chemicals. (The Senate version of the bill is available; the House version should be soon.) PFAS contamination has, as Beyond Pesticides documented in two Daily News Blog articles (here and here), become a huge, life-altering problem for agricultural producers in Maine and many other states. An early 2022 Safer States analysis of state-level legislation on PFAS demonstrated the extent of the problem via the response: more than 32 states have begun to act on the issue. Beyond Pesticides has covered the presence of PFAS in pesticides and pesticide containers, and in so-called “biosludge” or “biosolids”— realities that only reinforce the call for a rapid transition off of chemical-dependent agriculture and to regenerative organic agricultural practices that do not carry the enormous health and environmental risks of pesticide products and contaminated fertilizers. There […]

(Beyond Pesticides, October 27, 2022) A study published in Environment International adds to the growing body of research evaluating the association between neonicotinoid insecticides (neonics/NIs) and breast cancer. Past studies suggest neonics act as endocrine disruptors, affecting the development and regulation of estrogen hormones that promote breast cancer. However, this study is one of the few to evaluate the toxicological and molecular mechanisms involved in initiating breast cancer events. According to the Centers for Disease Control and Prevention (CDC), breast cancer is a disease that causes breast cells to grow out of control, with the type of breast cancer depending on the cells themselves. Most common forms of breast cancer have receptors on the cell surface that can increase cancer growth when activated by estrogen, progesterone, or too much of the protein called HER2. One in ten women will receive a breast cancer diagnosis, and genetics can only account for five to ten percent of cases. When a cancer cell lacks receptors for these molecules, G protein-coupled estrogen receptors (GPERs) are an essential biological target of estrogen and plays a role in hormone-dependent cancer development. GPERs regulate estrogen through non-genetic cellular pathways, forgoing attachment to standard molecular receptors, leading to triple-negative breast cancer (TNBC). Although past […]