(Beyond Pesticides, December 11, 2015) Milk contaminated with the long-banned and toxic organochlorine pesticide heptachlor in Hawaii has been found  in the brains of men that were more likely to develop Parkinson’s disease, according to a new study. This study adds to a large body of evidence linking pesticide exposure to Parkinson’s disease. Researchers of the study, titled “Midlife milk consumption and substantia nigra neuron density at death” and published in the journal Neurology, collected milk intake data from 1965 to 1968 for 449 men aged 45-68 years withpostmortem examinations from 1992 to 2004. Neuron density was measured in an area of the brain called substantia nigra (SN). As Parkinson’s develops, cells are destroyed in certain parts of the brain stem, particularly in the SN, a crescent-shaped cell mass. Measurements of brain residues of heptachlor epoxide, a heptachlor metabolite that is persistent and more toxic than its parent chemical, were also taken. “Among those who drank the most milk, residues of heptachlor epoxide were found in 9 of 10 brains as compared to 63.4%…for those who consumed no milk,” the researchers wrote. Neuron density was lowest in subjects who consumed the highest amounts of milk. The researchers looked at milk […]

(Beyond Pesticides, December 10, 2015) Researchers at Pennsylvania State University (Penn State) and the Pennsylvania Association for Sustainable Agriculture published a study, which found that aerial drift of the herbicide dicamba adversely affects non-target plants and pollinator species. Dicamba is a chlorinated benzoic acid herbicide associated with neurotoxicity and reproductive effects. The study used alfalfa crops to track the flowering and floral visitation by insects, specifically pollinators, after applications of sublethal doses of dicamba. The researchers concluded, “Our results suggest that widespread non-target damage from these herbicides may adversely affect pollinator communities.” Because dicamba is “frequently responsible for sublethal, off-target damage” to plants and insects, Penn State researchers assessed the most common route of exposure: particle and vapor drift. In its  study, Effects of the Herbicide Dicamba on Nontarget Plants and Pollinator Visitation, the research team examined the crop species alfalfa (Medicago sativa), which requires insect pollination to produce seeds, and the native plant species common  boneset (Eupatorium perfoliatum), which is highly attractive to a wide range of pollinator species. The researchers applied a range of sublethal doses of dicamba to the plants, then tracked flowering and floral visitation by insect species. They identified the types of insects visiting the […]

(Beyond Pesticides, December 4, 2015) Home Depot, the world’s largest home-improvement chain, has announced that it will no longer use  neonicotinoid (neonic) pesticides (which have emerged as the leading class of pesticides responsible for bee declines) in  80 percent of its flowering plants, and that it will complete its phase-out in plants by 2018. This follows the announcement made by Lowe’s earlier this year to phase out the sale of products containing neonicotinoid pesticides within 48 months. On its Eco Options gardening page, Home Depot says the following: “Our live goods suppliers have reduced the number of plants that they treat with neonicotinoids, so that now over 80% of our flowering plants are not treated HomeDepotWinBPwith neonicotinoids. We will continue this decrease unless,  1) it is required by state or federal regulation, or  2) undisputed science proves that the use of neonicotinoids on our live goods does not have a lethal or sub lethal effect on pollinators. Otherwise we will have a complete phase-out of neonicotinoid use on our live goods by the end of 2018.” “It’s important that retailers begin to make the switch toward safer products for bees, butterflies, and other beneficial insects,” said Jay Feldman, executive director […]

(Beyond Pesticides, November 23, 2015) Commonly-used pesticides can impact aquatic species over multiple weeks, even when chemicals are no longer detectable in water nor  monitored by regulators, according to new research. The study, titled A long-term assessment of pesticide mixture effects on aquatic invertebrate communities,  published in the journal Environmental Toxicology and Chemistry, investigates the long-term effects on aquatic invertebrate communities of commonly-used insecticides: two pyrethroids (permethrin and lambda-cyhalothrin) and an organophosphate (chlorpyrifos). Pesticide applications were based on environmentally relevant concentrations and lethal concentrations (a concentration required to kill a certain percentage of animals tested) ranging from 10% (LC10) to 50% (LC50). Researchers made repeat applications in order to mimic runoff events in a multiple grower or homeowner watershed. The results indicate that insecticide mixtures continue to impact natural systems over multiple weeks, even when bound to particles and no longer detectable in water. Combinations of indirect and direct effects caused consequences across the food chain. Pyrethroids rapidly dissipated from the water column, whereas chlorpyrifos was detectable even six weeks after application. “The effects we observed indicate that many species were affected at a sublethal level,” said Simone Hasenbein, Ph.D., lead author of the study tells Phys.org. “Thus, populations exposed […]

(Beyond Pesticides, November 18, 2015) Last week, the European Union’s (EU) European Food Safety Agency (EFSA) announced its determination that the popular herbicide glyphosate is “unlikely to pose a carcinogenic hazard to humans.” This is in direct contrast with findings released  earlier this year by  the World Health Organization’s (WHO) International Agency for Research on Cancer (IARC), which classified glyphosate a ”˜probable carcinogen.’  However, these seemingly conflicting conclusions from these premier scientific agencies are put into perspective by knowing that EFSA’s report is limited in that it reviewed glyphosate alone, unlike IARC which reviewed glyphosate and its formulated products (Monsanto’s Roundup) which are more relevant for evaluating risks to human health. In light of the March 2015 IARC findings —listing glyphosate as a probable carcinogen due to  sufficient evidence of carcinogenicity  based on laboratory studies, the European Commission requested EFSA consider glyphosate’s potential carcinogenicity. In its report released November 12, 2015, EFSA concludes that “glyphosate is unlikely to pose a carcinogenic hazard to humans and the evidence does not support classification with regard to its carcinogenic potential..” However, the agency notes that there are “several reasons explaining the diverging views” from IARC’s earlier conclusion. The most important difference is that […]

(Beyond Pesticides, November 16, 2015) Bayer CropScience, the manufacturer of neonicotinoid pesticides that are linked to severe decline in pollinator populations, is expected to pay fines to multiple countries in Europe for wine grape damages associated with another of its pesticides. Citing “atypical symptoms” resulting from the use of a relatively new fungicide, Bayer initially sent out a warning to wine growers to cease use of their product. Now, Bayer is collecting data and assessing how much it will offer to wine growers for the damages its product has caused. European grape growers, including vineyards in Austria, France, Germany, Italy, Luxembourg and Switzerland, have reported deformed leaves and lower yields after using Moon Privilege, also known as Luna Privilege in some markets, from the German company’s CropScience unit. In Switzerland, losses are estimated at 80 million Swiss francs ($83.73 million), as reported by marketing group Swiss Wine to Reuters. Swiss Wine’s general secretary estimates harvest losses totaling 6.65 million kilos (14 million pounds) of grapes in 2015, or about  4.85 percent of 2014’s crop. It is also estimated that wine makers have lost approximately six million bottles of wine, with  Pinot Noir grapes and Chasselas, a white wine grape, hardest […]

(Beyond Pesticides November 4, 2015) On Monday, the Center for Biological Diversity, the Center for Environmental Health, El Quinto Sol de America, Californians for Pesticide Reform, the Center for Food Safety and the Pesticide Action Network released a report with findings that that more than half of the commercial glyphosate sprayed in California is applied in the state’s eight most impoverished counties. Glyphosate is a phosphanoglycine herbicide that inhibits an enzyme essential to plant growth.  Commonly known as Roundup, glyphosate is classified as a probable carcinogen by the World Health Organization’s International Agency for the Research of Cancer (IARC), based on sufficient evidence of carcinogenicity in experimental animals, and is currently under review to receive a similar designation from the state under California’s Safe Drinking Water and Toxic Enforcement Act of 1986 (Proposition 65). The report,  Lost in the Mist:  How Glyphosate Use Disproportionately Threatens California’s Most Impoverished Counties, found that 54 percent of glyphosate spraying in California is applied in eight counties, many of which are located in the southern part of the Central Valley. The analysis finds that the populations in these counties are predominantly Hispanic or Latino, indicating that glyphosate use in California is distributed unequally along […]

(Beyond Pesticides, October 26, 2015) Last week, Pop Weaver, the second largest popcorn supplier in the country, released an official statement on its commitment to “removing 50 percent of its neonicotinoid usage in 2016, 75 percent in 2017, with a long-term commitment of further reducing usage by working with agricultural universities and those companies supplying neonicotinoids to the seed industry.” Widely-used neonicotinoids (neonics), which as systemic chemicals move through a plant’s vascular system and express poison through pollen, nectar, and guttation droplets, have been identified in multiple  peer-reviewed studies  and by beekeepers  as the major contributing factor in bee decline. This commitment is a response to a campaign led by Center for Food Safety (CFS), which asked citizens to sign a petition asking Pop Weaver, and other large popcorn suppliers, to protect bees and other pollinators by phasing out the use of neonicotinoid-coated corn seed. Over 37,000 people have signed their petition. Americans eat, on average, 17.3 billion quarts of popcorn each year; each American eats about 68 quarts. According to CFS, there are roughly 40 insecticides currently registered for use as an active chemical on popcorn, including 3 bee-toxic neonicotinoid chemicals: clothianidin, thiamethoxam, and imidacloprid. Between  79 and 100 […]

(Beyond Pesticides, October 23, 2015) Tests on produce collected by California’s Department of Pesticide Regulation (CDPR) for 2014 show high levels of  illegal toxic pesticide residues. The CDPR report found 1 percent of produce containing an excess amount of pesticide residues, and an additional 5.5 percent of produce tested contained illegal residues of pesticides that are not allowed for use on that product. Additionally, the data shows residues of a banned  chemical, which was taken off the market  over 20 years in the U.S. due to health concerns related to farmworker exposure. These findings showcase issues related to  system-wide failure in  enforcement. Advocates stress that violations may continue to occur due to inadequacies in regulations governing enforcement authorities, which include warnings or low fines for violators. In raising concerns about the safety of food grown with chemical-intensive methods, advocates point to the need to expand the transition to organic agriculture for better protection of public health and safety. The highest percentage of illegal pesticides was found on cactus pads and cactus fruit imported from Mexico. Some of the other tainted fruit and vegetables include limes, papaya, summer squash, tomatillos, chili peppers, and tomatoes, also from Mexico, ginger imported from China, […]

(Beyond Pesticides, October 9, 2015) Last week, the Environmental Protection Agency (EPA) released preliminary human health and ecological risk assessments for seven organophosphate pesticides (OPs) and announced the public open comment period for those chemicals. These risk assessments come as a result of the required periodic registration review, as required by  the Federal Insecticide, Fungicides, and Rodenticide Act. In general, OPs are highly toxic and many have been voluntarily removed from the market, considerably restricted, or denied reregistration. Unfortunately, EPA continues to rely on risk mitigation for individual OPs instead of phasing them out altogether. Seven OPs ­ ­—dimethoate, dictrotophos, chloyrophos-methyl, tribufos, terbufos, profenofors, and ethoprop—are among the first wave of chemicals whose preliminary risk assessments have been completed under the registration review program. Each of these was found by EPA to inhibit the enzyme acetylcholine esterase (AchE), which ultimately leads to neurotoxic  central nervous system effects. This information is not new, however. In 2012, University College London found long-term low-level exposure to OPs produces lasting damage to neurological and cognitive functions. In 2013, at least 25 children died after eating school lunches contaminated by OPs. One OP in particular, chlorpyrifos, chlorpyrifos (Dursban), is currently under petition for the same […]

(Beyond Pesticides, October 6, 2015) Last week, the International Federation of Gynecology and Obstetrics (FIGO) released a statement encouraging broad-based policy measures that prevent exposure to toxic environmental chemicals. “The global health and economic burden related to toxic environmental chemicals is in excess of millions of deaths and billions of dollars every year,” the report unequivocally states. FIGO’s statement follows a similar call to action from the American College of Obstetricians and Gynecologists in 2013 and the American Academy of Pediatrics in 2012. The piece lays out broad themes surrounding exposure to toxic chemicals, including issues of environmental justice, prenatal exposure and subsequent health effects, and overall global health and economic burden. Based on these impacts, several recommendations are submitted for obstetricians, gynecologists, midwives, women’s health nurse practitioners, nurses, and other health professionals to follow to achieve a goal of “prevention for all.” FIGO highlights how people of low-income, particularly in poverty-stricken countries, bare a higher burden of toxic exposure than richer nations. “[A]t every stage of development, the consequences of exposure to toxic chemicals —including morbidity and mortality, loss of family income and productivity, and environmental degradation— are disproportionately borne by people with low incomes,” the piece states. FIGO […]

(Beyond Pesticides, September 18, 2015) Glyphosate’s harmful effects continue to accumulate, this time with evidence pointing to toxic and sublethal effects on bees. According to a new study conducted by German and Argentinian researchers, honey bees exposed to low levels of glyphosate have a hard time returning home. Glyphosate, the  controversial and toxic active ingredient in Monsanto’s Roundup, is an herbicide widely used on genetically-engineered (GE) crops as well as on parks and golf courses, for control of weeds and grasses. Along with neonicotinoids, which have been linked to worldwide bee decline by a growing body of science, glyphosate is just another chemical in the toxic mixture that bees and other non-target organisms are constantly exposed to in the environment. In the study, titled “Effects of sublethal doses of glyphosate on honeybee navigation” and published in the Journal of Experimental Biology, researchers evaluate the effects of recommended concentrations of glyphosate used in agricultural settings on honey bee navigation and found that a single exposure to a concentration of glyphosate within this range delays the return of the foraging honey bee to the hive. Flight trajectories were also affected after successive exposure to the herbicide, suggesting that the spatial learning process […]

(Beyond Pesticides, September 11, 2015) On Thursday, the Ninth Circuit Court of Appeals unequivocally rejected the U.S. Environmental Protection Agency’s (EPA) unconditional registration of the systemic and bee-toxic pesticide sulfoxaflor. The Court concluded that EPA violated federal law and its own regulations when it approved sulfoxaflor without reliable studies regarding the impact that the insecticide would have on honey bee colonies. The Court vacated EPA’s unconditional registration of the chemical, meaning that sulfoxaflor may no longer be used in the U.S. However, while the decision is good news for now, it still leaves the door open for sulfoxaflor’s future use once EPA obtains the necessary information regarding impacts to honey bees and re-approves the insecticide in accordance with law. The case is Pollinator Stewardship Council, American Honey Producers Association, National Honey Bee Advisory Board, American Beekeeping Federation, Thomas Smith, Bret Adee, Jeff Anderson v. U.S. EPA (9th Circuit U.S. Court of Appeals,  No. 13-7234). Dow AgroSciences (a Dow Chemical company)  joined  the case as an intervenor to support EPA. EPA initially proposed to conditionally register sulfoxaflor and requested additional studies to address gaps in the data regarding the pesticide’s effects on bees. A few months later, however, EPA unconditionally registered […]

(Beyond Pesticides, September 10, 2015) Last week, California Environmental Protection Agency’s Office of Environmental Health Hazard Assessment (OEHHA) announced that it intended to list glyphosate (Roundup) and three other chemicals as cancer-causing chemicals under California’s  Safe Drinking Water and Toxic Enforcement Act of 1986 (Proposition 65). Glyphosate  is a phosphanoglycine herbicide that inhibits an enzyme essential to plant growth. Under California law, Proposition 65 requires that certain substances identified by the International View postAgency for Research on Cancer (IARC) be listed as known cancer-causing chemicals. In March, a study by the IARC classified glyphosate as a Group 2A material, which means that the chemical is carcinogenic based on sufficient evidence of carcinogenicity in experimental animals. The agency considered the findings from an EPA Scientific Advisory Panel report, along with several recent studies in making its conclusion. However, industry supporters of glyphosate all over the globe are conducting their own studies to attempt to prove that it is not a carcinogen. These studies, like one by German Federal Institute for Risk Assessments (BfR), are based almost solely on industry science and classified industry reports, each of which might not consider critical variables. With more glyphosate-focused studies being released, the growing evidence […]

(Beyond Pesticides, September 4, 2015) Research into neonicotinoid insecticides, a class of bee-toxic chemicals, and their effects on bees, needs to be more comprehensive in order to better reflect their global use, concludes a recent review of the current literature. The authors of the review state that despite considerable research efforts, there are still significant knowledge gaps concerning the impacts of neonicotinoids on bees. Since 2006, honey bees and other pollinators in the U.S. and throughout the world have experienced ongoing and rapid population declines. The science has become increasingly clear that pesticides (especially the  neonicotinoid class of insecticides), either acting individually or synergistically, play a critical role in the ongoing decline of honey bees and wild pollinators. Neonicotinoids can be persistent in the environment, and have the ability to translocate into the pollen and nectar of treated plants. The systematic review, titled Neonicotinoid Insecticides and Their Impacts on Bees: A Systematic Review of Research Approaches and Identification of Knowledge Gaps  and published in the journal PLoS ONE, took a look at over 200 primary research studies in order to identify knowledge gaps. While there is a growing body of science examining the impacts of neonicotinoid use, knowledge gaps need […]

(Beyond Pesticides, September 1, 2015) A  research study published in the journal Environmental Health  links chronic, ultra-low dose exposure to glyphosate in drinking water to adverse impacts on the health of liver and kidneys. The study, Transcriptome profile analysis reflects rat liver and kidney damage following chronic ultra-low dose Roundup exposure, is the latest in a string of data showing unacceptable risks resulting from exposure to glyphosate and products formulated with the chemical, like Monsanto’s Roundup. Researchers conducted the study by exposing rats to minute (0.1 parts per billion) doses of Roundup in drinking water for a period of 2 years. After noting tissue damage and biochemical changes in the blood and urine of exposed animals that was indicative of organ damage, the authors attempted to confirm their findings by analyzing changes in gene expression within liver and kidneys. Of 4,447 gene transcript clusters analyzed by scientists, 4,224 showed some alteration. Compared to non-exposed rats, “[t]here were more than 4,000 genes in the liver and kidneys whose levels of expression had changed,” said Michael Antoniou, PhD, senior author of the study to Environmental Health News. Authors indicate that the changes in gene expression observed in the study are associated with […]

(Beyond Pesticides, August 27, 2015) Last week, Philip J. Landrigan, M.D., and Charles Benbrook, Ph.D., released a perspective article, GMOs, Herbicides, and Public Health, in the New England Journal of Medicine  that outlines  the hazards associated with food residues of  elevated pesticide use in the production  of genetically engineered (GE) crops. While mainstream media continuously misses the central issue  in the GE debate by asserting that these crops are merely an extension of selective breeding and effect a reduction in pesticide use, the authors  focus on  the significance of the actual increase in herbicide use and weed resistance in herbicide-tolerant crops. Drs. Landrigan and Benbrook offer two main recommendations in their article: the U.S. Environmental Protection Agency (EPA) should delay implementation of its decision to permit the use of Enlist Duo (the 2,4-D herbicide used with  Monsanto-engineered GE herbicide-tolerant  crop), and  the U.S. Food and Drug Administration (FDA) should  require labeling of GE foods and couple it with adequately funded, long-term postmarketing surveillance. Dr. Landrigan, Dean for Global Health at Mount Sinai School of Medicine, is an epidemiologist and pediatrician and one of the world’s leading advocates of children’s and environmental health. Dr. Benbrook is a research professor at the […]

(Beyond Pesticides, August 19, 2015) Local fogging for  mosquito control turned tragic for a Palo Alto, California beekeeper who lost hundreds of honey bees from his backyard hives. The beekeeper, who also produces organic honey, now fears his honey is contaminated. The fogging, which occurred last month, was in response to positive tests for West Nile virus in mosquito samples. Many mosquito control pesticides are toxic to honey bees and given the declining populations of pollinators, vector control officials are being asked to carefully consider the risks associated with pesticide spraying. According to the local NBC affiliate, beekeeper Rondolph Tsien believes he was not given sufficient time to protect his bees from the mosquito fogging and, despite trying to cover his hives with a tarp to protect his bees from drifting pesticides, many were lost. A mosquito sample tested positive for West Nile virus about one mile from Mr. Tsien’s home, putting his property in the catchment area for fogging. Mr. Tsien worries the surviving bees will produce contaminated honey that can no longer be labeled organic. A Santa Clara County Vector Control representative stated during an interview that the county uses  an “extremely low dose” of pesticides during fogging […]

(Beyond Pesticides, August 10, 2015) It is with great sadness that we report that Louis Guillette, Jr., Ph.D., died from complications of cancer treatment on Thursday, August 6. He was 62.  Lou was an incredible inspiration, communicator, researcher, and teacher. And, beyond that, he was a truly good guy and beloved among students, researchers, and environmental and public health advocates. Our understanding of biology is deeper and the world is better off because of Lou. His work revolutionized scientific thinking and showed us the real world consequences of toxic chemical contamination and exposure. The first time that Lou spoke at a Beyond Pesticides’ Forum, over two decades ago, he challenged classical toxicology and taught us, with his signature clarity, that our regulations and high dose experimentation missed the mark in assessing low dose exposure to environmental contaminants and their  impact on the endocrine system –and what it all means to healthy living systems. Lou’s dedication to bringing science to people made him such a special person. We will cherish his talk this past April in capturing the essence of his work and the importance of it to the sustainability of life. See Lou’s talk to the 33rd National Pesticide Forum, […]

(Beyond Pesticides, August 4, 2015) Nearly every food available for purchase at the U.S. Congressional Dining Hall contains detectable levels of neonicotinoids (neonics), chemical insecticides implicated in the global decline of wild and managed pollinators. The results of a new study, performed by the American Bird Conservancy (ABC) and the Harvard T.H. Chan School of Public Health, reveals how reliance on these toxic chemicals can both directly and indirectly affect  our food supply. Authors of the study hope the results will build Congressional support for the Saving America’s Pollinators Act of 2015, which would suspend the use of neonics while an independent review analyzes the chemical’s effects to birds, pollinators, and other wildlife. Researchers for the study conducted two rounds of food testing, the first in January, and the second in May 2015. Approximately half of samples were taken from the House Longworth Cafeteria and half from Senate Dirksen Cafeteria in Washington, D.C. In total, 66 food samples were tested for the presence of neonicotinoids. Of that, 60, or 91% of samples tested positive for one neonic, and 47, or 71% of samples had two or more neonics present. “We were surprised to find that most foods contained multiple neonicotinoids, […]

(Beyond Pesticides, July 28, 2015) Data published from the Harvard School of Public Health reveals  neonicotinoids (neonics), a class of chemicals implicated in the global decline of honey bees and other pollinators, in over 70% of both pollen and honey samples collected throughout the state of Massachusetts during months when bees are most actively foraging. The results of this study have grave  implications for pollinator health, as even minute, near-infinitesimal doses of neonics can cause sublethal impacts that compromise the health of entire bee colonies. The Harvard study, led by Chensheng (Alex) Lu, PhD, and published in the Journal of Environmental Chemistry, took monthly honey and pollen samples from 62 volunteered bee hives between April and August 2013. The 219 pollen and 53 honey samples were then analyzed for the presence of eight neonic insecticides. Every month, in every location, researchers found neonics in the pollen and honey collected by bees. In total, 73% of pollen samples and 72% of honey samples contained at least one neonicotinoid at levels which could result in sublethal harm. While previous studies have tested the presence of neonics at a single point in time, this is the first study to show the long-term persistence […]

(Beyond Pesticides, July 22, 2015) Months after the World Health Organization (WHO) formally associated the world’s most widely used herbicide  -glyphosate (Roundup)- with cancer, one of the world’s leading experts on cancer risk, and co-author of the WHO’s report, Christopher Portier, PhD, told a scientific briefing in London that the herbicide can damage human DNA, which could result in increased cancer risks. This finding comes on the heels of a call by the Soil Association for a United Kingdom (UK) ban on the use of glyphosate after finding residues of the chemical in bread. Earlier this spring, the WHO’s International Agency for Research on Cancer (IARC) classified glyphosate as Group 2a “probable” human carcinogen based on sufficient evidence of carcinogenicity in laboratory animals. Since then industry has hit back defending its champion product, even attempting to undercut the WHO’s findings with an industry-based  assessment that reached the opposite conclusion, based on classified industry reports.  Now an internationally recognized scientist, Dr.  Portier, former associate director, National Institute of Environmental Health Sciences, (NIEHS) and director of the Office of Risk Assessment Research at NIEHS, reiterated WHO’s findings at the UK Soil Association scientific briefing in Westminster on July 15. During his presentation, […]

(Beyond Pesticides, July 6, 2015) With the release of its  Tier 1 screening results  for the first 52 pesticide chemicals (active and inert ingredients) evaluated under  the Endocrine Disruptor Screening Program (EDSP), the U.S. Environmental Protection Agency (EPA) is at odds with a large body of scientific evidence worldwide that identifies many of these chemicals, most notably the herbicides  2,4-D  and  atrazine,  as interacting with the endocrine system or acting as endocrine disruptors. Independent scientific data has shown these chemicals to interfere with the hormone system. EPA’s EDSP is a multi-step process used to ensure that exposure to chemicals does not result in adverse human health and environmental effects that canoccur from the disruption of hormones. The two-tiered screening and testing system requires that EPA identify which chemicals are able to interact with the endocrine system, specifically with three hormonal pathways — estrogen, androgen, and thyroid — in Tier 1. Tier 2 is designed to go one step further, requiring EPA to determine endocrine effects across taxa (e.g. mammals, birds, amphibians, and invertebrates) as well as potential effects on non-endocrine systems (e.g. neurological, immunological, hepatic, and renal).  According to EPA, Tier 1 screening data are the best way to determine […]