(Beyond Pesticides, December 6, 2010) A new study finds that exposure to dioxin in the womb can affect female reproduction for generations, reducing fertility and increasing the chance for premature delivery. Scientists from the Women’s Reproductive Health Research Center at Vanderbilt University School of Medicine examined the effects of a specific variety of dioxin on female mice and found that subsequent generations of the mice exposed to dioxin are at risk. The study, entitled “Developmental exposure to TCDD reduces fertility and negatively affects pregnancy outcomes across multiple generations,” was published in the journal Reproductive Toxicology. Dioxin refers to a family of chemicals linked to cancer, endocrine disruption, weakened immune systems and reproductive problems. They are persistent organic pollutants that bioaccumulate in humans and other animals, especially in fatty tissue, meaning that concentrations of dioxin in the body generally increase with age. So, even in very low doses, dioxins can cause health problems. Scientists in this study specifically looked at the variety of dioxin that is considered the most toxic, known as 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD). TCDD is a well-known contaminant of the herbicide 2,4-D, which was originally a part of the deadly chemical weapon Agent Orange. As such, TCDD is still found […]

(Beyond Pesticides, November 17, 2010) Researchers with the U.S. Geological Survey (USGS) have found a dozen agricultural fungicides in the waters and sediments downstream of farms and orchards in western states. Presented November 8, 2010 at the annual meeting of the Society of Environmental Toxicology and Chemistry (SETAC) in Portland, Oregon, the findings represent the first such data on fungicides in the western U.S. Farmers routinely use fungus-killing compounds to spray or dust food crops, such as strawberries, corn, and soybeans. Some crops receive up to a dozen doses per growing season. Nationwide, fungicide use has risen considerably since the 1990s, reaching 350 million pounds in 2001. However, the environmental prevalence and effects on wildlife and ecosystems, particularly of newer fungicides, are poorly understood, says Kathryn Kuivila, PhD, of the USGS California Water Science Center. Environmental monitoring programs monitor concentrations of few or no fungicides, she notes. The study entitled, “Occurrence of Azoxystrobin, Propiconazole, and Selected Other Fungicides in US Streams, 2005—2006,” documents the occurrence of fungicides in select U.S. streams soon after the first documentation of soybean rust in the U.S. and prior to the corresponding increase in fungicide use to treat this problem. Water samples were collected from […]

(Beyond Pesticides, October 21, 2010) Last week, the U.S. Environmental Protection Agency (EPA) announced that it has forwarded to the Secretary of Agriculture a draft proposed rule to amend EPA’s protocol for the testing of pesticides on humans. This draft proposed rule is a result of a settlement agreement reached on June 2010 in a lawsuit over its 2006 final rule. The 2006 final rule lifted a ban on human testing put in place by Congress. It allows experiments in which people are intentionally dosed with pesticides to assess the chemicals’ toxicity and allows EPA to use such experiment to set allowable exposure standards. In such experiments, people have been paid to eat or drink pesticides, to enter pesticide vapor “chambers,” and to have pesticides sprayed into their eyes or rubbed onto their skin. The pesticide industry has used such experiments to argue for weaker regulation of harmful chemicals. The coalition that challenged the regulation argued in the U.S. Court of Appeals for the Second Circuit that the rule ignores scientific criteria proposed by the National Academy of Sciences, did not prohibit testing on pregnant women and children, and even violated the most basic elements of the Nuremberg Code, including […]

(Beyond Pesticides, October 14, 2010) Over 13,000 organizations and individuals -consumers, parents, health advocates, farmworkers and others- from across the U.S. sent a letter to the Environmental Protection Agency (EPA) yesterday calling for a ban on the insecticide chlorpyrifos and a phase out of other organophosphate (OP) pesticides. Chlorpyrifos was phased out for residential use under a 2000 agreement between EPA and Dow Agrosciences, but continues to expose farmworkers and consumers through its use in agriculture. Also on October 13, the Endocrine Disruption Exchange (TEDX), led by renowned scientist Theo Colborn, PhD, announced the addition of chlorpyrifos to its online database, Critical Windows of Development, spotlighting research that links prenatal, low dose chlorpyrifos exposure to altered health outcomes in the brain and other organs. “Human studies have now linked prenatal exposure to chlorpyrifos with mental and developmental delays emphasizing even more the urgency to remove the product from the market,” said Dr. Colborn, President of TEDX and a signatory on the letter. “Chlorpyrifos illustrates the urgent need to be cautious, prevent further exposure and protect our children from the time they are conceived onward.” Beyond Pesticides calls EPA’s 2000 chlorpyrifos settlement with Dow a classic failure of the risk assessment […]

(Beyond Pesticides, September 28, 2010) A study published in the September 2010 issue of the journal Environmental Health Perspectives links low dose exposure to some persistent organic pollutants (POPs) to type 2 diabetes. The authors report that some POPs, including highly chlorinated PCBs, PBB153 and the organochlorine insecticides trans-nonachlor, oxychlordane and mirex, were associated with type 2 diabetes over an 18-year period, especially in obsese people. However, POPs did not show a traditional dose—response relationship with diabetes. Instead, POPs showed strong associations at relatively low exposures. The authors conclude that exposure to relatively low concentrations of certain POPs may play a role in the increased incidence of diabetes in the United States. The study, “Low Dose of Some Persistent Organic Pollutants Predicts Type 2 Diabetes: A Nested Case—Control Study,” examines participants who were diabetes free in 1987—1988. By 2005—2006, the 90 controls remained free of diabetes, whereas the 90 cases developed diabetes. Using serum collected in 1987—1988, the authors measured 8 organochlorine pesticides, 22 polychlorinated biphenyl congeners (PCBs), and 1 polybrominated biphenyl (PBB). They compare POP concentrations from Coronary Artery Risk Development in Young Adults (CARDIA) cohort and the National Health and Nutrition Examination Survey (NHANES) in 2003—2004. Persistent organic […]

(Beyond Pesticides, September 22, 2010) The National Conversation on Public Health and Chemical Exposures, a collaborative initiative aimed at developing an action agenda for strengthening the nation’s approach to protecting the public’s health from harmful chemical exposures, has drafted six work group reports on cross-cutting public health and chemical exposure topics. Public comment is invited and has been extended to Monday, September 27, 2010. Supported by the Centers for Disease Control and Prevention (CDC) and the Agency for Toxic Substances and Disease Registry (ASTDR), the National Conversation is a collaborative project that was launched in June 2009 to engage CDC, ATSDR, other organizations working on chemical exposure issues, and the public to develop an action agenda with clear, achievable recommendations that can help government agencies and other organizations strengthen their efforts to protect the public from harmful chemical exposures. Beyond Pesticides is an active participant in the National Conversation. Six work groups have convened to research and make recommendations on public health and chemical exposure issues. Public comment is needed for each work groups’ final reports as they work to develop the action agenda. To view work group reports and instructions for submitting comments, visit each work group’s page: Monitoring […]

(Beyond Pesticides, September 20, 2010) California-based discount retailer 99 Cents Only Stores Inc. has been fined over $400,000 for selling three household products containing unregistered or mislabeled pesticides. It is the largest contested penalty ever handed down by EPA. According to EPA, the retailer continued to sell the products even after being notified that they were violating regulations. EPA found 99 Cents Only Stores were selling products in violation of the Federal Insecticide Fungicide and Rodenticide Act (FIFRA) during a routine inspection in 2004. Subsequent inspections up until 2008 found additional problems resulting in a total of 166 separate violations. Originally. EPA handed down a $1 million fine. 99 Cents Only Stores Inc decided to contest the penalty. These types of fines are rarely contested. In the end, EPA Administrative Law Judge Susan Biro ruled the company would pay a fine of $409,490, declaring the retailer’s management had a “culture of indifference.” Of the 166 violations committed by 99 Cents Only stores Inc., 164 were related to a household cleaner and sanitizer imported from Mexico called Bref Limpieza y Disinfeccion Total con Densicloro which translates into “Bref Complete Cleaning and Disinfection with Densicloro.” The product had pesticidal claims on the […]

(Beyond Pesticides, August 31, 2010) As the Environmental Protection Agency (EPA) continues its review of the popular herbicide atrazine, a new study shows that male rats prenatally exposed to low doses of the gender-bending chemical are more likely to develop prostate inflammation and to go through puberty later than non-exposed animals. The research adds to a growing body of literature on atrazine, an herbicide used in agriculture, especially in corn and sugar cane production, and on golf courses and residential lawns. Atrazine and its byproducts are known to be relatively persistent in the environment, potentially finding their way into water supplies. It has been linked to a myriad of health problems in humans including disruption of hormone activity, birth defects, and cancer. The research, “Effects of prenatal exposure to a low dose atrazine metabolite mixture on pubertal timing and prostate development of male Long-Evans rats,” which is available online and will be featured on the cover of Reproductive Toxicology (Vol. 30, # 4), found that the incidence of prostate inflammation went from 48 percent in the control group to 81 percent in the male offspring who were exposed to a mixture of atrazine and its breakdown products prenatally. The severity […]

(Beyond Pesticides, August 20, 2010) Behind closed doors this past Monday, the U.S. Environmental Protection Agency (EPA) and Bayer CropScience reached an agreement on a set of measures to gradually reduce and ultimately ban fully the use of the insecticde aldicarb in the U.S. This decision arrives on the heels of a revised risk assessment in which EPA found that babies and children under the age of five can ingest levels of the insecticide through food and drinking water at levels that exceed limits that the agency finds safe, and 25 years after 2,000 people fell ill after eating watermelons that were tainted with the pesticide. Though Beyond Pesticides applauds any decision to remove toxic chemicals from the environment, the problem with this cancellation, as with virtually all voluntary cancellations, is that the chemical can be legally used for years —eight years in this case — leaving open the opportunity for continued human and environmental exposure and harm. The decision was reached after EPA completed a revised risk assessment indicating that the pesticide does not meet the agency’s food safety standards. EPA scrutinized recent food consumption data from USDA to complete the risk assessment, which considered the percent of the […]

(Beyond Pesticides, August 5, 2010) A 400-year old large old grape vine considered to be the nation’s oldest in Manteo, North Carolina and known lovingly as “Mother Vine,” is slowly recovering from a powerful dose of herbicide sprayed by a utility company. The Virginia-based Dominion Power Company contracted Lewis Tree Service to spray power poles along the roads in the Manteo in May. The herbicide they used, Garlon3A, was accidentally sprayed on a tiny shoot from the vine that had grown a few feet up a pole on 84-year old Jack Wilson’s property. Unaware of the recent herbicide spraying by the utility power company, he noticed various brown, dead sections that began to appear in the plant in May. Not only did the vine suffer, but about 10 feet of a nearby hedge died, along with three limbs of a large pecan tree that had to be trimmed. The active ingredient in Garlon 3A, a Dow Chemical product, is triclopyr. It is a systemic herbicide which means that the poison spreads from the ends of the vine back toward the root. As a broadleaf weed killer, triclopyr is frequently used along rights-of-way and on industrial sites. In laboratory tests, triclopyr […]

(Beyond Pesticides, August 3, 2010) A new study shows that due to a flaw in standard risk assessments, which consider toxic effects at fixed exposure times, the risks posed by the neonicotinoid pesticides imidacloprid and thiacloprid are likely to be underestimated. The authors believe that minute quantities of imidicloprid may be playing a much larger role in killing bees over extended periods of time than previously thought. The study, “The significance of the Druckrey—Küpfmüller equation for risk assessment””The toxicity of neonicotinoid insecticides to arthropods is reinforced by exposure time,” was published online July 23, 2010 in the journal Toxicology. The authors believe that standard risk assessment calculations underestimate toxicity because they do not accurately account for the interplay of time and level of exposure. According the study: The essence of the Druckrey—Küpfmüller equation states that the total dose required to produce the same effect decreases with decreasing exposure levels, even though the exposure times required to produce the same effect increase with decreasing exposure levels. Druckrey and Küpfmüller inferred that if both receptor binding and the effect are irreversible, exposure time would reinforce the effect. The Druckrey—Küpfmüller equation explains why toxicity may occur after prolonged exposure to very low toxicant […]

(Beyond Pesticides, July 27, 2010) Groups filed a lawsuit in federal court to force the Environmental Protection Agency (EPA) to decide whether or not it will cancel all remaining uses and tolerances for the pesticide chlorpyrifos, which has been banned for residential use, but continues to expose farmworkers and consumers through its use in agriculture. In September 2007, the Natural Resources Defense Council (NRDC) and Pesticide Action Network North America (PANNA) filed a petition with EPA asking the agency to ban chlorpyrifos. In the nearly three years since, the agency has not responded. NRDC and PANNA v. EPA, filed by the nonprofit environmental law firm Earthjustice on July 22, 2010, would force EPA to make a decision on the pesticide’s ban. “This dangerous pesticide has no place in our fields, near our children, or on our food,” said Earthjustice attorney Kevin Regan. “We’re asking a court to rule so that EPA will finish the job and ban this poison.” According to Beyond Pesticides, EPA’s 2000 negotiated settlement with Dow AgroSciences, which allows the highest volume chlorpyrifos uses to continue, represents a classic failure of the risk assessment process (including the so-called cumulative risk assessment which accounts for all chemicals with […]

(Beyond Pesticides, June 21, 2010) Pesticide experiments using people as test subjects will have stricter federal rules to follow under a new agreement reached on June 17, 2010 between the U.S. Environmental Protection Agency (EPA) and public health groups, farm worker advocates and environmental organizations. “People should never have been used as lab rats for testing pesticides,” said Natural Resources Defense Council (NRDC) senior attorney Michael Wall. “Under today’s settlement, EPA will propose far stronger safeguards to prevent unethical and unscientific pesticide research on humans.” In 2006, a coalition of health and environmental advocates and farmworker protection groups led by NRDC filed a lawsuit against EPA, claiming EPA’s recent rule violated a law Congress passed in 2005 requiring strict ethical and scientific protections for pesticide testing on humans. EPA’s 2006 rule lifted a ban on human testing put in place by Congress. It also allows experiments in which people are intentionally dosed with pesticides to assess the chemicals’ toxicity and allows EPA to use such experiment to set allowable exposure standards. In such experiments, people have been paid to eat or drink pesticides, to enter pesticide vapor “chambers,” and to have pesticides sprayed into their eyes or rubbed onto their […]

(Beyond Pesticides, June 16, 2010) Men with certain genetic variations who were exposed to some toxic pesticides that are now largely banned run an increased risk of developing Parkinson’s disease, French scientists said Monday. In a study published in Archives of Neurology, entitled “Interaction Between ABCB1 and Professional Exposure to Organochlorine Insecticides in Parkinson Disease,” French researchers found that among men exposed to pesticides such as DDT, carriers of the gene variants are three and a half times more likely to develop Parkinson’s than those with the more common version of the gene. The scientists think the brains of people with the gene variant fail to flush out toxic chemicals as efficiently as those with common versions of the gene, suggesting that environmental as well as genetic factors are important in the risk of Parkinson’s. Alexis Elbaz, MD, PhD and Fabien Dutheil, PhD, of France’s National Institute for Health and Medical Research (INSERM) studied 101 men with Parkinson’s and 234 without the disease to look at links between organochlorine exposure and Parkinson’s disease. The study includes only men, and all of them had high levels of exposure to pesticides through their work as farmers. The scientists found the link was […]

(Beyond Pesticides, June 1, 2010) Atrazine, one of the most commonly used herbicides in the world, has been shown to affect reproduction of fish at concentrations below U.S. Environmental Protection Agency’s (EPA) water-quality guideline, according to a new U.S. Geological Survey (USGS) study. “Concentrations of atrazine commonly found in agricultural streams and rivers caused reduced reproduction and spawning, as well as tissue abnormalities in laboratory studies with fish,” said USGS scientist Donald Tillitt, Ph.D., the lead author of the study, “Atrazine Reduces Reproduction in Fathead Minnow (Pimephales promelas)” published in Aquatic Toxicology. Fathead minnows were exposed to atrazine at the USGS Columbia Environmental Research Center in Columbia, Missouri, and observed for effects on egg production, tissue abnormalities and hormone levels. Fish were exposed to concentrations ranging from zero to 50 micrograms per liter of atrazine for up to 30 days. All tested levels of exposure are less than the EPA Office of Pesticides Aquatic Life Benchmark of 65 micrograms per liter for chronic exposure of fish. Study results show that normal reproductive cycling was disrupted by atrazine and fish did not spawn as much or as well when exposed to atrazine. Researchers found that total egg production was lower in […]

(Beyond Pesticides, May 11, 2010) Even with the growing body of evidence linking environmental exposures to cancer in recent years, a report released May 6, 2010 by the President’s Cancer Panel finds that the true burden of environmentally-induced cancer is greatly underestimated. The Panel’s report, Reducing Environmental Cancer Risk: What We Can Do Now, concludes that while environmental exposure is not a new front on the war on cancer, the grievous harm from this group of carcinogens has not been addressed adequately by the nation’s cancer program. “There remains a great deal to be done to identify the many existing but unrecognized environmental carcinogens and eliminate those that are known from our daily lives — our workplaces, schools and homes,” said LaSalle D. Leffall, Jr., M.D., chair of the Panel. “The increasing number of known or suspected environmental carcinogens compels us to action, even though we may currently lack irrefutable proof of harm,” he added. Beyond Pesticides applauds the chairman’s precautionary approach and encourages President Obama to heed the panel’s call to “use the power of your office to remove the carcinogens and other toxins from our food, water, and air that needlessly increase health care costs, cripple our Nation’s […]

(Beyond Pesticides, April 1, 2010) While most previous literature on melanoma has focused on host factors and sun exposure, new research shows a link between several pesticides and this deadly form of skin cancer. Epidemiologists from University of Iowa, the National Institute of Environmental Health Sciences and National Cancer Institute found that agricultural workers who apply certain pesticides to farm fields are twice as likely to contract melanoma, providing support for the hypotheses that agricultural chemicals may be another important source of skin cancer risk. The study, “Pesticide use and cutaneous melanoma in pesticide applicators in the Agricultural Heath Study” was published last month in the journal Environmental Health Perspectives. It examines cancer rates in 56,285 pesticide applicators in Iowa and North Carolina as part of the federal government’s Agricultural Health Study, a large, long-term study of pesticide applicators and their spouses. Researchers asked the pesticide applicators how often they were exposed to 50 pesticides and compared their cancer rates. Each person’s exposure was then approximated by adding up the total days that the workers had been exposed and using information from survey results on how the chemicals were applied and what protective equipment was being used. The pesticides that […]

(Beyond Pesticides, March 25, 2010) A new study finds that the absence of a maximum dose on some household pesticides labels leave consumers with the impression that “if a little is good, more is better.” According to the study that was presented at the 239th National Meeting of the American Chemical Society (ACS), label directions are written in a way that may result in consumers using excessive amounts of pesticides, subjecting their family and pets to increased exposures. The new study, which was lead by California Environmental Protection Agency researcher Linda M. Hall, Ph.D., and her colleagues, finds that while minimum and maximum doses are clearly listed on labels for agricultural pesticides, labels for some household pesticides, such as para-dichlorbenzene (pDCB) mention the minimum amount for consumers to use but do not indicate the maximum. Para-dichlorobenzene (pDCB) is the active ingredient in mothballs and other products used to protect silk, wool, and other natural fibers against moths and beetles; caged birds against lice and mites; mildew prevention; and is also used in air fresheners and bathroom deodorizers. Exposure to moth repellents, which include other toxic chemicals such as naphthalene and camphor, can cause eye and respiratory irritation, headaches, confusion and […]

(Beyond Pesticides, March 24, 2010) Due to a significant increase in adverse incidents, the U.S. Environmental Protection Agency (EPA) is taking a series of actions aimed at increasing the safety of spot-on pesticide products for flea and tick control for cats and dogs. EPA will begin reviewing labels to determine which ones will require new instructions and labeling for on-spot flea products. EPA began investigating the products after discovering a sharp rise in the number of dogs and cats reported to be sick. Incidents reported by consumers rose from 28,895 in 2007 to 44,263 in 2008, an increase of 53 percent. The products investigated, including the popular Frontline and Advantage brands, are small vials of liquid pesticides that pet owners apply monthly to the backs of dogs or cats to kill fleas and ticks. EPA began investigating the products after discovering a sharp rise in the number of pets reported to be sick after they were treated. The year long investigation, conducted by a team of veterinarians assembled by the agency, concluded that certain pets — small dogs between 10 and 20 pounds — are most susceptible to the problems, which include rashes, vomiting, diarrhea and seizures. EPA plans to […]

(Beyond Pesticides, March 16, 2010) The New Hampshire House of Representatives passed a measure last week to study the passage of a bill, HB 1456, that would establish a New Hampshire General Court committee to study the use of pesticides and their alternatives in areas where children may be exposed. Yes, that’s right; they passed a bill to study a study bill. The House majority committee proposed the interim study bill as an alternative to seeking a floor vote on HB 1456 itself because of the bill opponents’ view that the safety of pesticides is unquestionable and fear that HB 1456 would lead to a moratorium on lawn pesticides, much like what has been done throughout Canada. HB 1456 is the first state bill in the country to be successfully introduced and have a hearing with intent to restrict toxic pesticide use on public and private property, showing the momentum that is building throughout the country on this issue. At the House Environment and Agriculture Committee hearing on HB 1456 in February, the issue of studying the impact of pesticides, mainly herbicides, on children where they are commonly used in residential neighborhoods, on school grounds, playgrounds, and other places where […]

(Beyond Pesticides, March 4, 2010) Scientists at Purdue University have found that nanosilver that is sonicated or suspended in solution is toxic and even lethal to fathead minnows, an organism that is often used to measure toxicity on aquatic life. The study is the latest research to demonstrate the need for federal regulatory agencies to regulate emerging nanotechnologies as a unique pesticide. The study, “The effects of silver nanoparticles on fathead minnow (Pimephales promelas) embryos,” led by Maria Sepúlveda, PhD and published in Ecotoxicology, describes the toxicity of two commercial silver nanoparticle products: NanoAmor and Sigma. Fathead minnows at several stages of their development were exposed to varying concentrations of either suspended or stirred nanoparticle solutions for 96 hours. When the nanosilver was allowed to settle, the solution became several times less toxic, but still caused malformations in the minnows. With or without sonication, nanosilver caused irregularities, including head hemorrhages and edema, and was ultimately lethal. “Silver nitrate is a lot more toxic than nanosilver, but when nanosilver was sonicated, or suspended, its toxicity increased tenfold,” said Dr. Sepúlveda. “There is reason to be concerned.” Using Transmission Electron Microscopy, Dr. Sepúlveda was able to detect nanosilver particles measuring 30 nanometers […]

(Beyond Pesticides, March 3, 2010) A recently published study in the Proceedings of the National Academy of Sciences finds that male frogs exposed to the herbicide atrazine can become so completely female that they can mate and lay viable eggs. This latest study adds to the growing scientific evidence which shows that atrazine, one of the most common herbicides used in the U.S., disrupts the development and behavior of aquatic animals, and negatively effects their immune, hormone, and reproductive systems. The study, “Atrazine induces complete feminization and chemical castration in male African clawed frogs (Xenopus laevis),” led by Tyrone Hayes, PhD, at the University of California, Berkeley, demonstrates the reproductive consequences of atrazine exposure in adult amphibians. Dr. Hayes and other researchers examined a group of 40 African clawed frogs, all of which carried male chromosomes. As tadpoles, the frogs were put in water with 2.5 parts per billion (ppb) of atrazine — a concentration within federal drinking water standards. Atrazine-exposed males were both demasculinized (chemically castrated) and completely feminized as adults. Exposed genetic males developed into functional females that copulated with unexposed males and produced viable eggs. The eggs produced were all male offspring since both parents contributed male […]

(Beyond Pesticides, February 9, 2010) In an innovative development that could transform the way Americans view the origins of learning and developmental disabilities, the national Learning and Developmental Disabilities Initiative (LDDI) released the first-ever biomonitoring report identifying toxic chemical pollution in people from the learning and developmental disability community. Mind, Disrupted: How Toxic Chemicals May Affect How We Think and Who We Are examines 61 toxic chemicals present in project participants in the context of rising rates of autism, attention-deficit hyperactivity disorder, and other learning and developmental disabilities.   In the U. S., 5-15% of children under age 18 are affected by learning and developmental disabilities. Reported cases of autism spectrum disorders have increased tenfold since the early 1990s. Based on current research, the Centers for Disease Control and Prevention (CDC) states that 1 in 110 eight-year-old children have autism in the United States. Mind, Disrupted measured levels of a set of neurotoxic and endocrine-disrupting chemicals in the participants’ bodies. A growing body of peer-reviewed scientific research, including animal and human studies, shows that these chemicals can disrupt the development and functioning of the brain and nervous system. Eleven of the twelve study participants had detectable levels of triclosan in […]