(Beyond Pesticides, September 8, 2022) A study published in Environmental Pollution finds parental exposure to real-world, sublethal concentrations of pesticide residues on grains is a major contributor to unfavorable offspring development among foraging birds. Parents’ ingestion of grains with conventional pesticide residues, whether from contaminated or pesticide-treated seeds, results in chronic exposure that adversely affects offspring health, even at low doses. The adverse effects pesticides and other environmental pollutants have on birds are amply documented and researched. Although many studies evaluate acute or chronic health implications associated with pesticide exposure in a single generation, there is a lack of information on multi-generational impacts that can provide vital information on the fundamental survivability or fitness of bird species. Considering this study emphasizes parental exposure to environmental pollutants can have adverse consequences for future generations, it is necessary that future risk assessments for birds address these implications when implementing agricultural pesticide policies. The study notes, “[S]ublethal effects of such compounds [pesticides] on non-target species should be included in the regulation. Moreover, as agroecosystem pollution is not resulting only from pesticides, there is an urgent need to analyze cocktail effects, not only between molecules of pesticides but also between pesticides and other pollutants such as […]

(Beyond Pesticides, September 7, 2022) Neonicotinoid (neonic) insecticides are causing widespread contamination within deer populations in Minnesota, with recent data showing significant increases over sampling that took place just two years earlier. The Minnesota Department of Natural Resources (MDNR) began sampling the spleens of deer in the state after research conducted in South Dakota found widespread contamination, but also links to harmful effects as a result of the exposure. The latest findings will result in further testing, yet the sum of research on the dangers of neonicotinoids – not only to deer, but pollinators, birds, aquatic wildlife, and even human health – demands, according to advocates, a precautionary approach and meaningful restrictions on these potent systemic pesticides. Officials at MDNR have no explanation for the increase in contamination over the last sample period. “We’re not exactly sure why we saw that increase,” said Department of Natural Resources Ungulate Research Scientist Eric Michel, PhD, to mprnews.org. “But regardless, the two years of data are showing us that neonics are being detected pretty much across the state. When we look for them we find them in deer spleens. So that’s kind of the big takeaway from what we’re seeing right now.” Results […]

(Beyond Pesticides, September 2, 2022) Revelations of toxic risks to pregnant people seem to emerge with alarming frequency. In late August a peer-reviewed study published in Chemosphere finds that the compound melamine, its primary byproduct (cyanuric acid), and four aromatic amines were detected in the urine of nearly all pregnant research participants. These chemicals are associated with increased risks of cancer, kidney toxicity, and/or developmental harm to the resultant child. Beyond Pesticides has covered a variety of pregnancy risks from pesticides and other toxic chemicals, including these in just the last three years: pesticides and children’s sleep disorders; prenatal exposures to a multitude of chemicals; insecticides and childhood leukemia; insecticides and Attention Deficit/Hyperactivity Disorder. Those of a certain age may hear “Melamine” and think of the nearly indestructible plastic dinnerware from the mid-20th century, but “melamine” is an organic chemical compound that, when combined with formaldehyde, forms a durable plastic. Others may remember the 2007–2008 incident in China of contamination of infant formula with melamine, which resulted in six deaths, and kidney and urinary tract harms (ranging from development of kidney stones to acute renal failure) in some 300,000 babies. [A small sidebar explainer: melamine was actually intentionally added to the formula […]

(Beyond Pesticides, September 1, 2022) Low level exposure to synthetic pyrethroid insecticides at 6-8 months of age is associated with language development delays in two-year old toddlers, according to research published in Neurotoxicology this month. This is the latest study to link this class of chemicals to developmental delays in young children. Despite a steady drum of concerning research, the U.S. Environmental Protection Agency (EPA) in 2019 removed a crucial “safety factor” intended to protect children’s health from synthetic pyrethroids, allowing higher levels of the insecticides to be sprayed on food, in homes, and playing fields around the country.   To investigate the impact of synthetic pyrethroids on language development, scientists enrolled 327 expectant mothers in their third trimester. The mothers, all from rural areas of China, were selected if they had no history of significant pesticide exposure or family history of serious disease. Urine samples were taken from the women during pregnancy, and from infants 6-8 months after birth. Scientists analyzed samples for concentrations of three different synthetic pyrethroid breakdown products (metabolites), including 3-phenoxybenzoic acid (3PBA), 4-fluoro-3-phenoxybenzoic acid (4F3PBA), and cis-2,2dibromovinyl-2,2-dimethylcyclopropane-1-carboxylic acid (DBCA). While 3PBA is a metabolite of many synthetic pyrethroids, 4F3PBA a more specific metabolite of cypermethrin, […]

(Beyond Pesticides, August 31, 2022) No rainwater on Earth is safe for consumption and use as per-, and poly-fluoroalkyl substances (PFAS) readily contaminate the hydrological ecosystem (properties, distribution, and circulation of water), according to a study published in Environmental Science and Technology. This finding is concerning as it adds to research demonstrating chemical pollutants (e.g., pesticides, pharmaceuticals, PFAS, heavy metals, radioactive material, etc.) exceed the “planetary boundary” contamination and needs addressing. The Stockholm Resilience Centre, Stockholm University study, “Planetary Boundaries: Exploring the Safe Operating Space for Humanity,” emphasizes that there are nine “planetary boundaries” related to climate change, biodiversity loss, the nitrogen cycle, the phosphorous cycle, stratospheric ozone depletion, ocean acidification, global freshwater use, changes/intensification of land use, atmospheric aerosol loading, and chemical pollution. When crossing these boundaries, the risk of generating large-scale abrupt or irreversible environmental changes increases. In fact, anthropogenic (human) activities are increasing global contamination levels past safe thresholds. Studies have already found that current human operations are quantifiable in almost all nine planetary boundaries and exceed the threshold for at least four out of the nine boundaries. Most recently, a 2022 report concludes that humanity exceeds planetary boundaries related to environmental pollutants and other “novel entities,” including plastics and pesticides. […]

(Beyond Pesticides, August 30, 2022) Minuscule amounts of the weed killer Roundup and its active ingredient glyphosate can result in damage to the nervous system, finds research led by scientists at Florida Atlantic University, published in Scientific Reports. As hundreds of millions of pounds of glyphosate continue to be sprayed on hundreds of millions of acres of land throughout the United States each year, recent data indicate that four out of five U.S. children and adults contain detectable levels of glyphosate in their bodies. The pesticide industry and its paid supporters tell Americans that although contamination is widespread, the levels found in humans are not cause for concern. This latest research significantly undermines that specious argument, finding impacts on critical nervous system processes at levels 300 times less than the lowest suggested amount on the Roundup label. “It is concerning how little we understand about the impact of glyphosate on the nervous system,” said Akshay S. Naraine, MSc., coauthor and a PhD student at Florida Atlantic University. “More evidence is mounting for how prevalent exposure to glyphosate is, so this work hopefully pushes other researchers to expand on these findings and solidify where our concerns should be.”  To investigate the […]

(Beyond Pesticides, August 26, 2022) New research from a team in California finds one-third of pesticides it reviewed — including glyphosate, paraquat dichloride, and oxyfluorfen — to be associated with the development of thyroid cancer. Researchers investigated the links between exposure to pesticides — including 29 that cause DNA cell damage — and the risk of this cancer. The researchers also find that in all the single-pollutant models they employed, paraquat dichloride — a widely used herbicide — was linked to this cancer. In 2021, Beyond Pesticides covered research by the U.S. National Institutes of Health (NIH) that demonstrated that exposures to lindane and metalaxyl also cause heightened risk of thyroid cancer. These study findings add to the already considerable concern about pervasive pesticide exposure — not only among farmers and applicators, but also in the general population. It is worth noting that, in addition to elevated thyroid cancer risks, multiple pesticides can cause other health damage. Paraquat is also acutely toxic, and can cause longer-term reproductive, renal, and hepatic damage to humans; it is toxic to birds, fish, and other aquatic organisms, and slightly so to honeybees. Glyphosate, as Beyond Pesticides has written frequently, is carcinogenic, and is associated […]

(Beyond Pesticides, August 25, 2022) A study published in World Journal of Pediatrics finds an association between antibiotic and neonicotinoid (neonic) exposure and onset of pediatric (childhood) type 1 diabetes (T1D) through effects on the gut microbiome. Individuals with type 1 diabetes are at higher risk of other autoimmune disorders, including thyroid and celiac disease. Ample evidence demonstrates environmental contaminants like pesticides and antibiotics negatively affect human mouth and gut microbes. Through the gut biome, pesticide exposure can enhance or exacerbate the adverse effects of additional environmental toxicants on the body. Moreover, studies find low levels of pesticide exposure during pregnancy or childhood cause adverse health effects from metabolic/immune disorders to mental and physical disabilities. Children are particularly vulnerable to the impacts of pesticide exposure as their developing bodies cannot adequately combat exposure effects. Although studies show how chemical exposures affect overall human health, more research is now questioning how these toxic chemicals influence gut health and subsequent occurrence of diseases. In children, gut microbiome disruption, or gut dysbiosis, has significant associations with type 1 diabetes development, and disruption of gut microbiota plays a role in type 2 diabetes development. Over 11 percent (>37 million) of individuals in the U.S. have diabetes, and cases are growing by millions annually. With increasing rates of type 1 and […]

(Beyond Pesticides, August 24, 2022) New research is helping the medical community understand the mechanism through which exposure to the banned insecticide DDT increases risk of Alzheimer’s disease. Published in the journal Environmental Health Perspectives, a team of researchers from Florida International University and Rutgers used multiple models to demonstrate the effects of DDT on the production of toxic proteins in the brain. The constant stream of new health risks regarding a chemical banned decades ago underlines the importance of a precautionary approach to pesticide regulation, particularly as red flags are already being raised about the connection between widely used weed killers like glyphosate and neurodegenerative diseases like Alzheimer’s. “The vast majority of research on the disease has been on genetics — and genetics are very important — but the genes that actually cause the disease are very rare,” says study coauthor Jason Richardson, PhD of Florida International University. “Environmental risk factors like exposure to DDT are modifiable. So, if we understand how DDT affects the brain, then perhaps we could target those mechanisms and help the people who have been highly exposed.” Previous research from Dr. Richardson found that DDT exposure increased risk of Alzheimer’s by four times. Scientists […]

(Beyond Pesticides, August 23, 2022) Bees exposed to systemic insecticides become disoriented and cannot walk straight, showing evidence of brain damage in areas that coordinate movement, according to research published in Frontiers in Insect Science. Although scientific studies and regulatory determinations have already provided ample evidence implicating systemic insecticides like the neonicotinoids and sulfoxaflor with pollinator danger and decline, new research continues to fill in the remaining gaps. “Here we show that commonly used insecticides like sulfoxaflor and the neonicotinoid imidacloprid can profoundly impair the visually guided behavior of honey bees,” said lead author Rachel H Parkinson, PhD, a scientist at the University of Oxford. “Our results are reason for concern because the ability of bees to respond appropriately to visual information is crucial for their flight and navigation, and thus their survival.” Honey bees rely on landmarks, the direction of sunlight, and wide-field visual motion to orient themselves in a landscape, find nectar and pollen, and bring it back to the hive. While sunlight provides a compass, wide-field visual motion helps bees adjust speed and altitude, and determine where they are relative to known landmarks. Worker bees use this innate ability to reorient themselves to food or their hive […]

(Beyond Pesticides, August 18, 2022) A study published in Environmental Research suggests occupational (work-related) exposure to pesticides among nonpregnant women and men may increase childhood cancer risk for offspring. Already, studies find low levels of pesticide exposure during pregnancy or childhood cause adverse health effects from metabolic disorders to mental and physical disabilities. However, few assess parental exposure’s impact on childhood disease risk outside critical development periods (e.g., pregnancy). Although medical advancements in disease survival are more prominent nowadays, childhood cancer remains the leading cause of death from disease among children. Furthermore, childhood cancer survivors can suffer from chronic or long-term health complications that may be life-threatening. The etiology or cause of childhood cancer involves the interaction of multiple components like lifestyle and genetics. However, emerging evidence indicates that environmental contaminants like pesticides (e.g., occupational exposures, air pollution, pesticides, solvents, diet, etc.) play a role in disease etiology. Pesticide contamination is widespread in all ecosystems, and chemical compounds can accumulate in human tissues resulting in chronic health effects. Children are particularly vulnerable to the impacts of pesticide exposure as their developing bodies cannot adequately combat exposure effects. Moreover, several studies demonstrate an association between environmental or occupational pesticide exposure and the risk of childhood cancer. Considering maternal pesticide […]

(Beyond Pesticides, August 16, 2022) Over half of all food samples tested by the U.S. Food and Drug Administration (FDA) contain the residues of at least one pesticide, and one in ten samples have levels that violate legal limits established by the U.S. Environmental Protection Agency (EPA). These findings, published by FDA this month in its 2020 Pesticide Residue Monitoring Report, are simply par for the course for government regulators, as FDA indicates the 2020 results “were consistent with recent years.” However, while reporting on the dangerous pesticides present in U.S. food has become routine for FDA, more and more Americans are rejecting regular exposure to unnecessary toxics in their food by going organic with their food choices, planting their own pesticide-free gardens, and encouraging their elected officials to embrace safer, sustainable land care policies.   FDA has conducted a review of pesticide residues on food on an annual basis since 1987, evaluating both domestic and imported foodstuffs into the US market. While EPA sets “pesticide tolerances,” also known as “maximum residue levels,” of allowed pesticide residues on certain foods, FDA (and USDA, for some specific items like meat, poultry, and eggs) is tasked with enforcing these provisions. Pesticide tolerances, […]

(Beyond Pesticides, August 12, 2022) Gestational (during pregnancy) exposure to endocrine disrupting chemicals (EDCs) like pesticides, per- and polyfluoroalkyl substances (PFAS), among others, may increase pediatric (child) liver injury and non-alcoholic fatty liver disease (NAFLD) risk, according to a study published in Environmental Health. Past studies associate exposure to EDCs with increased susceptibility to adverse health effects during critical fetal and childhood developmental periods. The World Health Organization (WHO), European Union (EU), and endocrine disruptor expert (deceased) Theo Colborn, Ph.D., classify over 55 to 177 chemical compounds as endocrine disruptors, including various household products like detergents, disinfectants, plastics, and pesticides. Endocrine disruption can lead to several health problems, including hormone-related cancer development (i.e., thyroid, breast, ovarian, prostate, testicular), reproductive dysfunction, and diabetes/obesity that can span generations. Because EDCs are ubiquitous because they are found in many products, studies report that these toxic chemical compounds are detectable in infants, children, and pregnant women. Furthermore, pregnant women can readily transfer compounds to the developing fetus through the placenta. Therefore, it is essential to understand the mechanism behind how harmful chemical exposure induces endocrine disruption during critical developmental periods. Researchers note, “Considering the lack of studies on endocrine disruption and pediatric NAFLD, research like this highlights the need to understand the underlying […]

(Beyond Pesticides, August 11, 2022) A study in the International Journal of Environmental Research and Public Health finds that Brazilian agricultural workers are more likely to die from acute kidney failure (AKF) than other acute illnesses. Among the agricultural workers, the prevalence of AKF is higher for individuals at younger ages, who are female, and located in regions south of chemical use, particularly rural areas. However, the AKF mortality rate in urban areas is also increasing, but not as fast as in rural areas. Over six million people in the U.S. have kidney disease (i.e., nephritis [kidney inflammation], nephrotic syndrome (improper protein filtration), and nephrosis). Although many studies find an association between exposure to environmental contaminants like pesticides and chronic kidney disease (CKD), the association between pesticides and acute kidney failure remains unclear. CKD is a risk factor for AKF, and other environmental factors can increase the risk of AKF mortality. Therefore, studies like this highlight the need for comprehensive information regarding co-occurring exposure patterns and disease prevalence that can have global implications. The study notes, “Our findings reinforce the need for more robust epidemiological studies that account for co-exposures and conditions of agricultural work in the relationship between pesticide exposure and kidney […]

(Beyond Pesticides, August 10, 2022) Cover crops added in-between rows of organic corn while they are still growing can provide a range of benefits that improve a farm’s sustainability and lowers its impact on the surrounding environment, according to a study published in Agronomy Journal by scientists at Pennsylvania State University. “The use of cover crops in organic grain systems has many potential benefits,” says study coauthor Sarah Isbell, PhD. “These include improvements in soil quality, increased nutrient retention, prevention of erosion, and suppression of weeds. In organic systems where synthetic inputs are not used, cover crops can be managed to reduce nitrate leaching through soils and supply nitrogen to cash crops.” As demand for organic products continues to increase, and more and more farmers are embracing the organic mantra of “continuous improvement,” research like the present study is critical to the development of new efficiencies and ecologically sustainable practices. Scientists set out to understand the best method for planting cover crops under organic corn grown for grain or silage (fed to cattle and other animals). Determining a planting time for corn cover crops is difficult because corn is often harvested late in the fall, leaving little time for a […]

(Beyond Pesticides, August 9, 2022) The most widely used pesticide chemicals in the United States are not listed on product labels, yet pose widespread environmental and public health hazards, according to commentary published this month in Environmental Health Perspectives by two veteran researchers. At issue are adjuvants and so-called “inert” (or “other”) ingredients, chemicals that are added to formulated pesticide products, but do not undergo the same safety reviews as the active ingredient in pesticide products. This donut hole of regulation has permitted, as the commentary shows, millions of pounds of chemicals to be applied in California and throughout the country without proper scientific evaluation of their human health or ecological impact. Researchers first draw a distinction between adjuvant products and inert ingredients in pesticide products. Adjuvants are materials specifically designed to improve the performance of a pesticide spray and are sold separately from formulated pesticide products. Adjuvants are “tank mixed” with a pesticide prior its application. Inert ingredients are any ingredient within a formulated pesticide product that is not designed to prevent, destroy, or repel a pest. Adjuvants and inert ingredients can be the same material – the difference lies in when they are added to a formulated pesticide […]

(Beyond Pesticides, August 4, 2022) An Arizona State University (ASU) study shows that the popular herbicide glyphosate can infiltrate the brain through the blood (blood-brain barrier), increasing neurological disease risk. The blood-brain barrier filters various molecules entering the brain from the circulatory system. However, the permeation of glyphosate molecules elevates the expression of TNFα and the accumulation of soluble beta-amyloid (Aβ) proteins in the brain and has associations with immune, inflammatory, and neurodegenerative diseases like Alzheimer’s disease (AD). More than 6 million people in the U.S. are living with Alzheimer’s, and cases are expected to double by 2050. Although Alzheimer’s research has focused heavily on finding genetic causes of the disease, fewer than half of cases are genetic. Thus, researchers are now evaluating how environmental contaminants may increase disease risk. Over 300 environmental contaminants and their byproducts, including pesticides, are chemicals commonly present in human blood and urine samples and can increase neurotoxicity risk when crossing the brain barrier. Therefore, studies like this highlight the importance of understanding how chemical accumulation in the body can impact long-term health and disease prognosis. The study notes, “Brain glyphosate correlates with increased TNFα levels, suggesting that exposure to this herbicide may trigger neuroinflammation in the brain, which may […]

(Beyond Pesticides, August 3, 2022) A systematic review of scientific studies on pesticides and fertility finds exposure associated with lower semen quality, DNA fragmentation, and chromosomal abnormalities. Published in the journal Andrology, the review is yet another warning from a long string of researchers sounding the alarm over the connection between global fertility and toxic chemical exposure. With data from the U.S. Centers for Disease Control and Prevention (CDC)  indicating roughly 1 in 5 couples are unable to conceive after a year of trying, and trends continuing to slope downwards, it is critical that contributing factors be identified so that protective changes can be made.   After screening over 1,300 studies, researchers narrowed their review down to 64 papers assessing semen parameters and DNA integrity after pesticide exposure. Each study is analyzed for its design, the pesticide investigated,  the population studied, controls, and reproductive effects determined. Pesticides are evaluated for their impacts to sperm quality and DNA integrity based on their chemical class. Organochlorine insecticides, which are all banned but still persistent in soil, air, water, and food in the United States, include a range of impacts to sperm quality. Higher levels of DDT or its breakdown metabolite DDE are […]

(Beyond Pesticides, August 2, 2022) Members of the United States Senate are calling on the U.S. Fish and Wildlife Service (FWS) to phase out the use of toxic pesticides in National Wildlife Refuges in order to protect declining wildlife species and the country’s unique natural resources. Led by Senator Cory Booker (D-NJ), the senators sent a letter to FWS Director Martha Williams urging FWS to “expeditiously begin a rulemaking process to phase out the use of agricultural pesticides on National Wildlife Refuges.” The move comes at a time when native wildlife and the ecosystems humans rely upon are under greater threats than ever before from climate change, habitat destruction, and the indiscriminate use of toxic pesticides. “The Refuge System was established to provide sanctuary for listed threatened and endangered species, migratory birds, and other wildlife,” wrote the senators in a letter to U.S. Fish & Wildlife Director Martha Williams. “The Refuges’ migratory sanctuary and breeding grounds are especially critical for North American birds, as they have faced precipitous population declines; there are 3 billion fewer breeding birds in North America than there were in 1970. Unfortunately these birds and other threatened species are being put at risk by pesticide use […]

(Beyond Pesticides, July 29, 2022) Perhaps attempting to capitalize on the recent U.S. Supreme Court decision limiting the U.S. Environmental Protection Agency’s (EPA’s) ability to regulate carbon emissions, Senator Roger Marshall of Kansas (R) has filed a bill in the Senate that seeks to limit the agency’s ability to regulate pesticide use. The so-called EPA Transparency for Agriculture Products Act of 2022 is touted, on Senator Marshall’s website, as “a comprehensive bill to prevent . . . EPA . . . from overregulating essential pesticides that the ag industry heavily depends upon.” In truth — and perversely, given that he is a medical doctor — the bill aims to provide more license to use toxic pesticides that harm human health, the environment broadly, and ecosystems already under assault from toxic, synthetic pesticides and fertilizers, habitat destruction, and climate change. Couched in language about “feeding the world,” the bill’s central concern seems to be financial impacts or challenges that farms (a good portion of which, let us remember, are giant, well-resourced agribusinesses) may face because of EPA pesticide regulations. Those regulations, of course, are promulgated by the agency to protect people, organisms, ecosystems, and natural resources from harmful impacts and risks […]

(Beyond Pesticides, July 28, 2022) A report published in Chemosphere finds organophosphate (OP) insecticides readily contaminate drinking water resources, threatening human, animal, and ecological health. OPs have a wide range of biological uses—from insecticides to flame retardants—that make these chemicals ubiquitous, significantly contributing to ecosystem contamination. These compounds have a global distribution, with evaporation and precipitation facilitating long-range atmospheric transport, deposition, and bioaccumulation of hazardous chemicals in the environment. OPs are highly toxic, and residues are consistently present in human and animal blood, urine, tissues, and milk. Considering 90 percent of Americans have at least one pesticide compound in their body, primarily stemming from dietary exposure, including food and drinking water, advocates maintain that current restrictions on their use must adequately detect and assess total chemical contaminants.  Water is the most abundant and crucial chemical compound on earth, essential to survival, and the main component of all living things. Less than three percent of that water is freshwater, and only a fraction of that freshwater is groundwater (30.1%) or surface water (0.3%) readily available for consumption. However, ubiquitous pesticide use threatens to reduce the amount of available freshwater as pesticide runoff, recharge, and improper disposal tends to contaminate adjacent waterways, like rivers, streams, lakes, or underground watersheds. With rivers and streams only accounting […]

(Beyond Pesticides, July 26, 2022) Secret meetings with industry, the elevation of unqualified individuals to decision-making roles, using an untested scientific approach, failing to conduct a simple literature review, and an overall absence of public transparency. This is how the U.S. Environmental Protection Agency’s (EPA) conducted its cancer review for the potent fumigant pesticide 1,3-Dichloropropane (1,3-D; brand name: Telone), according to a report from EPA’s Office of Inspector General (OIG). EPA’s actions allowed a product once considered to pose a 1 in 10,000 risk of cancer to Americans to increase exposure by 9,000% (from 7.7 μg/m3 to 690 μg/m3). “These departures from established standards during the cancer assessment for 1,3-D undermine the EPA’s credibility, as well as public confidence in and the transparency of the Agency’s scientific approaches, in its efforts to prevent unreasonable impacts on human health,” the OIG report states. Yet, even with the agency’s failings laid out in clear view, EPA’s lackluster response to OIG’s corrective actions in this case add insult to its injurious actions against public health. OIG initiated a review of EPA’s cancer assessment for 1,3-D after the submission of multiple complaints. 1,3-D is a highly toxic fumigant used on a variety of crops, […]

(Beyond Pesticides, July 21, 2022) Research published in Scientific Reports finds an association between the increasing emergence of nonalcoholic fatty liver disease (NAFLD) and exposure to endocrine (hormone) disrupting chemicals, like organochlorine pesticides (OCPs). It is well-known that traces of legacy (past-use) pesticides, like organochlorines, remain in the environment for decades—possibly centuries, post-final application, as OCPs have greater chemical stability and gradual attenuation. However, these chemicals have profound adverse impacts on human health, especially on the endocrine system. Obesity, insulin resistance, type 2 diabetes, and elevated liver enzyme resulting from endocrine disruption contribute to NAFLD and can lead to liver cirrhosis. Although some, but not all, manufacturing and use of specific OCPs have declined in the U.S., OCPs remain a global issue, as much of the developing world still reports usage. Considering the lack of studies on OCP-induced endocrine disruption and NAFLD, research like this highlights the need to understand the underlying mechanisms that contribute to growing endocrine disease incidents.   The study determined that there is an association between OCP exposure and NAFLD using the fatty liver index (FLI), a predictor of lipid (fat) accumulation in the liver. The researcher collected blood serum to measure the concentration of OCPs, specifically evaluating detectable […]