(Beyond Pesticides, June 26, 2013) Pesticide use has sharply reduced the regional biodiversity of stream invertebrates, such as mayflies and dragonflies, finds a study published in the Proceedings of the National Academy of Science. While previous research has shown similar decreases in individual streams, this new study analyzes the effects of pesticides over broad regions. This is one of several recent findings that show pesticides pose a long-term threat to important ecosystems. The study, entitled Pesticides reduce regional biodiversity of stream invertebrates, notes that losses of biodiversity caused by anthropogenic activities during the past 50 years are unprecedented in human history. A team of researchers sampled 23 streams in the central plains of Germany, 16 in the western plains of France, and 24 in southern Victoria, Australia. Researchers classified streams according to three different levels of pesticide contamination: uncontaminated, slightly contaminated, and highly contaminated. Utilizing a model-based approach to account for other environmental variables, the team observed that losses in taxonomic diversity were, to a large degree, determined by the loss of species specifically vulnerable to pesticides. Overall, they found that there were up to 42% fewer species in highly contaminated than in uncontaminated streams in Europe. Highly contaminated streams […]

(Beyond Pesticides, April 24, 2013) Using the aquatic species Daphnia, commonly referred to as “water fleas,” scientists at North Carolina State University (NC State) determined that exposure to the pesticide pyriproxyfen impacted multiple generations, ultimately resulting in more male offspring, and causing reproductive problems in female offspring. Lead author Gerald LeBlanc, PhD, notes, “This work supports the hypothesis that exposure to some environmental chemicals during sensitive periods of development can cause significant health problems for those organisms later in life —and affect their offspring and, possibly, their offspring’s offspring.” The study, published in the journal PLoS One, provides the scientific community with new information on how organisms respond to the environmental signals resulting from pesticide exposure. Environmental cues normally determine whether the Daphina offspring will be male or female, according to the researchers. This study is part of an investigation to understand the mechanisms involved with these environmental cues. The NC State team had previously identified the hormone methyl farnesoate (Mf) as an important factor in determining the sex of the organisms at the embryotic stage. The scientists exposed Daphnia to varying levels of the pesticide pyriproxyfen, an insecticide that mimics the Mf hormone. The exposure resulted in Daphnia producing […]

(Beyond Pesticides, February 8, 2013) A recent study conducted at the University of Granada, Spain and published in the Journal Environmental Research proposes a link between exposure to persistent organic pollutants (POPs) in food, air, and water and prevalence of type 2 diabetes in adults, regardless of age, gender, and body mass index. The paper concludes that people with higher concentrations of DDE, the break down product of DDT, are four times more likely to develop type 2 diabetes compared to other participants in the study. Increased rates of type 2 diabetes are also associated with exposure to beta-hexachlorocyclohexane, a break down product of the toxic chemical lindane, which in still allowed for use in agriculture and certain formulations of products used to treat lice and scabies. The study was carried out by analyzing the concentrations of specific POPs in adipose, or fat, tissue of 386 adults undergoing non-cancer-related surgery in Spain. According to one of the authors of the study, Juan Pedro Arrebola, “Human adipose tissue acts as an energy reservoir and has an important metabolic function. However, adipose tissue can store potentially harmful substances, such as POPs.”    The study found that as concentrations of POPs grows in […]

(Beyond Pesticides, January 23, 2013) A new federal report finds toxic contamination remains widespread in the Chesapeake Bay, with severe impacts in some places, which health and environmental advocates say lends support to their push in Maryland for legislative action on pesticides and other hazardous chemicals. In spite of some cleanup, the health of the Bay has not significantly improved. The report, “Technical Report on Toxic Contaminants in the Chesapeake Bay and its Watershed: Extent and Severity of Occurrence and Potential Biological Effects” is based on a review of integrated water-quality assessment reports from the jurisdictions in the Bay watershed (Delaware, Maryland, New York, Pennsylvania, Virginia, West Virginia, and Washington, D.C.), Federal and State reports, and articles in scientific journals. It notes that nearly three-fourths of the Bay’s tidal waters are “fully or partially impaired” by toxic chemicals, with people warned to limit fish consumption from certain areas. Contamination is severe in a handful of “hot spots” around the Bay, including Baltimore’s harbor, largely a legacy of past industrial and shipping activity. Previous reports have called on federal, state and local government to accelerate research into what threats chemical contamination may pose to the Bay, and to step up efforts […]

(Beyond Pesticides, December 3, 2012) The Food and Drug Administration (FDA) has denied a 2010 petition filed by the National Resources Defense Council (NRDC) and Pesticide Action Network North America (PAN) to ban the insecticide lindane, which is harmful to human health and ineffective in controlling lice and scabies. Pressure had been mounting on FDA to halt the pharmaceutical use of lindane as, in addition to this petition, Congressman Edward J. Markey (D-Mass.), senior member of the Energy and Commerce Committee, asked FDA to stop the pharmaceutical use of lindane this past summer. Because of FDA’s decision, lindane is still an active ingredient in pharmaceutical insecticide products such as lice shampoos and lotions. Lindane was formerly used in agricultural insecticides until it was banned by the Environmental Protection Agency (EPA) for use on crops in 2006. FDA regulates pharmaceuticals that contain insecticides and pesticides, such as triclosan, that are in cosmetics. Over 160 countries including the United States have signed on to the Stockholm Convention on Persistent Organic Pollutants (POPs) in 2001 which aims to eliminate or restrict the production and use of persistent organic polluntants. Lindane along with nine other chemcials was added to this list on May 9th […]

(Beyond Pesticides, November 7, 2012) Pregnant beluga whales pass to their fetus a portion of the persistent organic pollutants, PCBs and flame retardants, they carry in their bodies, report researchers who measured the chemicals in the animals’ blubber. The study is one of the first to show whales, like people, can transfer and expose their developing offspring to persistent contaminants, whose long-term health effects continue to remain unclear. A study of Arctic beluga whales (Delphinapterus leucas) confirms that mothers can pass more than a tenth of their chemical burden of PBDE flame retardants and PCBs to their unborn calves. This study found that the mother whales transferred, on average, 11.4% (7.5”‰mg) and 11.1% (0.1”‰mg) of their polychlorinated biphenyl (PCB) and polybrominated diphenyl ether (PBDE) blubber burden to their near-term fetuses. Mammals transfer contaminants, usually persistent organic pollutants (POPs), during pregnancy to the developing fetus and during lactation when the baby is nursing. Lactation transfer has been well studied in marine mammals, but very little is known about the transfer of pollutants during pregnancy. POPs are resistant to environmental degradation through chemical, biological, and photolytic processes. Because of this, they have been observed to persist in the environment, to be capable […]

(Beyond Pesticides, August 2, 2012) Following the phase-out announcement two years ago, and after many years of pressure from environmental and international groups concerned about the chemical’s health effects, the U.S. Environmental Protection Agency (EPA) has finally begun the process of phasing out the use of the highly toxic endosulfan –an organochlorine insecticide in the same chemical family as DDT. The phase of endosulfan uses began on July 31, 2012 and will continue through July 31, 2016. In 2010, EPA negotiated a long phase-out agreement with endosulfan’s manufacturers that allows uses to continue through 2016, even though EPA concluded that endosulfan’s significant risks to agricultural workers and wildlife outweigh its limited benefits to growers and consumers, and that there are risks above the agency’s level of concern for aquatic and terrestrial wildlife, as well as birds and mammals that consume aquatic prey that have ingested endosulfan. This is an egregious example of how EPA uses phase out and existing stock provisions in negotiating with industry on removing known hazards from the market, placing economic interests over the protection of public health. In 2010, EPA decided that data presented in response to its 2002 reregistration eligibility decision (RED) demonstrated that risks […]

(Beyond Pesticides, August 1, 2012) New research is adding to the evidence that some pesticides and industrial chemicals may increase women’s risk of uterine and ovarian diseases, such as endometriosis. The research supports the decades old theory that hormone-mimicking chemicals impact human reproductive systems. Scientists have long suspected a link between estrogen-mimicking pollutants and gynecological diseases. According to Environmental Health News, research investigating a link between hormone-disrupting chemicals in the environment and gynecological diseases has had mixed results. But a new study, “Persistent Lipophilic Environmental Chemicals and Endometriosis: The ENDO Study,” from researchers at the National Institutes of Health and others, found that two groups of women in the Salt Lake City and San Francisco areas — one group with pelvic pain and the other with no symptoms — were more likely to be diagnosed with endometriosis if they had high blood levels of the estrogen-like pesticide hexachlorocyclohexane (HCH) than women with low levels. HCH, a persistent organic pollutant (POP), and a byproduct of the production of the insecticide lindane (head lice treatments), has been banned as a crop pesticide in the United States but it persists in the environment and remains in some food supplies. Endometriosis is a female […]

(Beyond Pesticides, July 9, 2012) Health officials in Connecticut are telling residents who drink from private wells to test their water for the banned pesticides chlordane and dieldrin, after a study from the town of Stamford, CT found at least one of the toxic chemicals in 195 out of 628 wells tested. Over half of the wells that tested positive for one of the pesticides were found to contain concentrations at levels above what the U.S Environmental Protection Agency (EPA) considers acceptable. Both of these chemicals, discussed at length in Rachael Carson’s seminal book Silent Spring, were widely used throughout the country before their ban in the late 1980s. Since then, these chemicals have revealed themselves to be pervasive in our environment. In 2007, Beyond Pesticides wrote on the discovery of chlordane on the grounds of a New Jersey middle school at levels above EPA limits. In 2009, the U.S Housing and Urban Development (HUD) and EPA conducted a survey that found chlordane in 64% of U.S households sampled. In 2010, we reported on the occurrence of these two historic-use chemicals in what are considered “pristine” National Parks. Unfortunately, if the water contamination residents are finding turns out to be […]

(Beyond Pesticides, June 21st, 2012) A new study details the toxic effects of long-term exposure to commonly used agricultural pesticides. Results indicate an increased likelihood of moderate to severe blood toxicity and a reduced total number of bone marrow cells, which can lead to degenerative diseases like aplastic anemia. The study, entitled “Pesticide Induced Alterations in Marrow Physiology and Depletion of Stem and Stromal Progenitor Population: An Experimental Model to Study the Toxic Effects of Pesticide” is published in the online version of the Journal of Environmental Toxicology . The experiment, led by researchers at the Calcutta School of Tropical Medicine’s Department of Biochemistry and Medical Biotechnology, exposed a group of mice to a mixture of organochlorine, organophosphate and pyrethriod pesticides, including a preponderance of the chemicals cypermethrin, and chloropyrofos. The exposed mice showed an overall reduction in the ability of their bodies to produce bone marrow cells. Bone marrow, the soft flexible tissue found in the interior of bones, is a storehouse for stem cells. While the exact mechanism is unknown to researchers, the study reveals that the microenvironment in which stem cells develop is somehow deranged by pesticides. This derangement prevents the maturation of stem cells into every […]

(Beyond Pesticides, March 21, 2012) A half-century after California officials discovered that large amounts of the pesticide DDT had been discharged into a San Francisco Bay canal, the chemical is still poisoning fish and posing a threat to human health despite numerous cleanup attempts. After years of limited success with clean-up, the U.S. Environmental Protection Agency (EPA) has launched a three-year plan to pinpoint the cause of continuously high DDT levels and engage the surrounding community in cleanup and education efforts. The former plant and the adjacent canal, called the Lauritzen Channel, an inlet of the greater San Francisco bay, is one of the most polluted places in the nation. DDT levels have not decreased in the channel even after numerous dredging and other mitigation measures. In fact concentrations have increased. By 2011, DDT concentrations exceeded 1994 levels and some fish have DDT levels in their tissues hundreds of times higher than their counterparts in the rest of the San Francisco Bay. EPA said earlier this month it is launching a three-year plan to help unravel the mystery of why cleanup attempts are failing, and will work with the city to increase awareness among anglers who rely on bay fish […]

(Beyond Pesticides, March 6, 2012) New research conducted in New Bedford, Massachusetts suggests that organochlorine chemicals, which were first linked to learning problems in children more than two decades ago, may play a role in attention-deficit hyperactivity disorder (ADHD), especially in boys. Previous research has reported associations between organochlorines and ADHD-related behaviors, but this research found sex-specific effects in children born to mothers who lived near the contaminated harbor and dumpsites in low-income communities. This study adds to a growing body of literature associating learning disorders with prenatal chemical exposures. According to the study, Neuropsychological Measures of Attention and Impulse Control among 8-Year-Old Children Exposed Prenatally to Organochlorines, boys who were exposed to higher levels of the organochlorines -polychlorinated biphenyls (PCBs) and DDE (a metabolite of DDT)- in the womb scored lower on focus and concentration tests, which indicates they are more likely to have attention problems often related to ADHD. In the study, umbilical cord blood was collected from 788 newborns born between 1993 and 1998 from four towns near New Bedford Harbor, Mass., to see what they were exposed to in the womb. Roughly eight years after they were born, almost 600 of these children underwent two tests. […]

(Beyond Pesticides, February 22, 2012) Researchers have found high levels of endosulfan, a highly toxic organochlorine pesticide, in the bone marrow of children, including those suffering from hematological malignancies (blood cancers) in areas using the pesticide. Children who have endosulfan in their bone marrow have 7.5 times more risk of developing blood-related cancer compared to those with no detectable pesticide in the bone marrow. While the findings are based on research in India, the insecticide is still used in the production of dozens of crops in the U.S., even though EPA found that exposure to the chemical exceeds the agency’s acceptable risk criteria and announced in 2010 a six-year negotiated phase-out plan with industry that stretches from 2012 to 2016. Following a lawsuit filed against the U.S. Environmental Protection Agency (EPA) in 2008, which cited EPA’s glaring omission in not considering risks to children, EPA announced in 2010 that it would, instead of stopping exposure to a known hazard immediately, phase-out over a six year period all uses of endosulfan in the U.S. Rather than regulating a stop use, EPA astounded many in the environmental and public health community by negotiating a long phase-out agreement with manufacturers that allows some […]

(Beyond Pesticides, February 1, 2012) Pesticides could be suppressing vitamin D levels in people, leading to deficiency and disease, say scientists. This comes from a new study which discovered that adults with high serum concentrations of organochlorine pesticides, such as DDT, have lower vitamin D levels, further proving that these chemicals have a long-lasting impact on human health. While not widely appreciated, some organochlorine pesticides continue to be used in the U.S., resulting in exposure through our diet, environment, and prescription drugs, while most organochlorine pesticides have been banned in the U.S. and much of the world. Exposure to low doses of organochlorine pesticides has been previously linked to common diseases like type 2 diabetes, metabolic syndrome and cardiovascular disease. Vitamin D deficiency has similarly been associated with a rise in chronic diseases, but the two have been studied separately by researchers in different fields. The study, “Associations between Organochlorine Pesticides and Vitamin D Deficiency in the U.S. Population,” compared serum concentrations of organochlorine (OC) pesticides with serum concentrations of 25-hydroxyvitamin D (25(OH)D), a vitamin D pre-hormone, which is used to assess vitamin D levels in the body. It concludes that background exposure to some OC pesticides can lead to […]

(Beyond Pesticides, November 15, 2011) Research published in the online edition of Environmental Health Perspectives finds that exposure to certain pesticides elevates the risk of non-Hodgkin’s Lymphoma (NHL). The study, “A Prospective Study of Organochlorines in Adipose Tissue and Risk of non-Hodgkin’s Lymphoma,” finds a positive correlation between levels of the organochlorine pesticides DDT, cis-nonachlor, chlordane, and their breakdown products in human fat tissue and the often deadly form of cancer. The researchers from the Danish Cancer Society’s Institute of Cancer Epidemiology conducted a case-cohort study using a prospective Danish cohort of 57,053 persons enrolled between 1993 and 1997. Within the cohort they identified 256 persons diagnosed with NHL in the population-based nationwide Danish Cancer Registry and randomly selected 256 sub-cohort persons. The research team measured concentrations of eight pesticides and ten polychlorinated biphenyl congeners (PCBs) in fat tissue collected upon enrollment. The results indicate a higher risk of NHL in association with higher fat tissue levels of DDT, cis-nonachlor and oxychlordane, but shows no association with PCBs. Because the tissue samples were taken up to 15 years prior to the cancer diagnosis, the research suggests that exposure to these organochlorines increases the risk of NHL later in life and […]

(Beyond Pesticides, October 14, 2011) Researchers at Uppsala University in Sweden have found that environmental toxicants such as dioxins, PCBs, and pesticides can pose a risk for cardiovascular disease. The results of the study, entitled “Circulating Levels of Persistent Organic Pollutants (POPs) and Carotid Atherosclerosis in the Elderly,” show a link between exposure to persistent organic pollutants (POPs), including several organochlorine pesticides, and the development of atherosclerosis, which can lead to heart disease. The study will be published in the journal Environmental Health Perspectives, and a version of it is available online ahead of print. Cardiovascular diseases, including heart attacks and strokes, are the most common cause of death in industrialized countries, and the most important underlying cause of these diseases is atherosclerosis. Unbalanced blood fats, diabetes, smoking, and high blood pressure are traditionally recognized risk factors for atherosclerosis. Previous studies have also reported possible links between cardiovascular disease and high levels of persistent (long-lived and hard-to-degrade) organic environmental toxicants, such as dioxins, polychlorinated biphenyls (PCBs), and pesticides. These compounds are fat-soluble and can therefore accumulate in vessel walls. However, no earlier studies have investigated possible links between exposure to these compounds and atherosclerosis. Of the POPs that were screened […]

(Beyond Pesticides, September 20, 2011) A study supported by the U.S. Army Medical Research and Materiel Command links pesticide exposure and other factors to Gulf War illness (also referred to as Gulf War Syndrome), an illness characterized by a wide range of acute and chronic symptoms experienced by veterans and civilians after the 1991 Gulf War. The study, “Complex Factors in the Etiology of Gulf War Illness: Wartime Exposures and Risk Factors in Veteran Subgroups,” is published in the September 19, 2011 online edition of Environmental Health Perspectives. The researchers designed the study to compare the characteristics of deployment and the risk factors experienced by veterans participating in various theaters of the Gulf War. Among personnel who were in Iraq or Kuwait, where all battles took place, four exposures were independently associated with GWI: taking PB pills, being within one mile of an exploding SCUD missile, using pesticides on the skin, and exposure to smoke from oil well fires. For veterans who remained in support areas, GWI was significantly associated only with personal pesticide use, with increased prevalence (OR=12.7, CI=2.6-61.5) in the relatively small subgroup who wore pesticide-treated uniforms, nearly all of whom also used skin pesticides. Among 64 pesticide […]

(Beyond Pesticides, August 30, 2011) A new study finds that older men living in California’s Central Valley are more likely to develop prostate cancer if they were exposed to certain agricultural pesticides than those who were not exposed. The study examines exposure via drift rather than occupational exposure, although similar results have been noted in farmworker populations. Exposure to methyl bromide or various organochlorine pesticides increased the risk of cancer by about one and a half times. The study, “Prostate cancer and ambient pesticide exposure in agriculturally intensive areas in California,” was published in the June 2011 issue of the American Journal of Epidemiology. The researchers from the University of Southern California’s Keck School of Medicine recruited 173 men between the ages of 60 to 74 from 670 identified by the California Cancer Registry as being diagnosed with prostate cancer between August 2005 and July 2006 in California’s Central Valley. The authors used calendars and questionnaires to determine where they lived and worked between 1974 and 1999, and compared this to historical data of the corresponding area’s agricultural pesticide use from state pesticide use reports and land use records. In comparison with unexposed persons, increased risks of prostate cancer were […]

(Beyond Pesticides, August 19, 2011) Children from disadvantaged backgrounds are exposed to higher levels of a slew of environmental chemicals — some currently used and some long banned — than U.S. children from other socioeconomic backgrounds, finds a study of elementary school children from urban Minneapolis, Minn. The 7- to 12-year-olds had elevated concentrations of metals, industrial chemicals and markers for pesticides and tobacco smoke in their blood and urine. The results are published in the Journal of Toxicology and Environmental Health. These findings agree with other studies reporting higher concentrations of environmental chemicals in children. What is important about this study is that these children were from low-income households where they face additional hardships from poverty. Children from disadvantaged backgrounds are more vulnerable to health issues, such as asthma and behavioral problems. Exposure to these chemicals may increase this risk even more. Compared to adults, children eat more food, breathe more air, and drink more fluid than adults per unit of body mass. This increases their intake of potentially harmful chemicals and possibly raises the risk of adverse health effects related to these compounds. In addition, children’s bodies are not fully capable of detoxifying many of these chemicals so […]

(Beyond Pesticides, August 2, 2011) Under pressure from lab results showing arsenic in apple juice, the U.S. Food and Drug Administration (FDA) and New York state officials inspected a Williamson, NY Mott’s apple products plant for the toxic metal on July 26, 2011. While the lab tests commissioned by the Rochester-based Empire State Consumer Project examined several brands of apple juice and apple sauce, Mott’s Apple Juice stood out, with one sample registering 55 parts per billion of arsenic, five times higher than the Environmental Protection Agency’s (EPA) legal limit (tolerance level) for drinking water. While no longer used in U.S. orchards, arsenic-based pesticides are still used on food crops in some countries, including China. “This is not the first time high levels of arsenic have been found in apple juice,” said Judy Braiman, executive director of the Empire State Consumer Project. “It is past time for the FDA to set a limit on a toxic substance like arsenic with long term health effects in the juice that kids drink.” Two-thirds of apple juice that Americans consume ””more than 400 million gallons annually”” comes from China. The Empire State Consumer Project and Food & Water Watch sent a letter to […]

(Beyond Pesticides, July 25, 2011) Exposure to certain pesticides and polycyclic aromatic hydrocarbons (PAHs) in the womb has been linked to neural tube defects, which lead to conditions such as spina bifida, according to researchers at Peking University in China. The study finds elevated levels of the organochlorine pesticides DDT, alpha-hexachlorocyclohexane (a lindane contaminant) and endosulfan, as well as PAHs in the placentas of women who had babies or aborted fetuses with such birth defects. The study, “Association of selected persistent organic pollutants in the placenta with the risk of neural tube defects,” was published July 8, 2011 in the online edition of the Proceedings of the National Academy of Sciences. While most organochlorine pesticides are banned or restricted, they still continue to cause problems decades after their widespread use has ended. This study reinforces the need for a more precautionary approach to regulating pesticides and industrial chemicals. Once released into the environment, many chemicals can affect health for generations, either through persistence or genetic means. PAHs are a group of over 100 different chemicals that are formed during the incomplete burning of coal, oil and gas, garbage, or other organic substances like tobacco or charbroiled meat. PAHs are usually […]

(Beyond Pesticides, July 11, 2011) The findings of a research team suggest that the concentrations of the banned but still persistent insecticide chlordane and the widely used insecticide permethrin in cord blood may be associated with inflammatory cytokines (signaling molecules of the nervous and immune system important to intercellular communication) in the fetus. The results from the research team were significant because few studies on the developmental effects of chlordane and permethrin in humans have been performed, and they were the first to demonstrate an association between in utero exposures with changes in the immune systems of newborns. The data and findings are found in this month’s Research Brief by the National Institute of Environmental Health Sciences (NIEHS) Superfund Research Program, which highlights the widespread aggregate pesticide exposure that individuals in the U.S. experience, focusing on a recent study on the developmental effects of chlordane and permethrin mixtures. The study looks at the relationship between cord serum concentrations of chlordane and permethrin pesticides, gestational age, size at birth and the presence of inflammatory cytokines, which are endogenous proteins secreted as signaling compounds to coordinate immune system functions. The study, entitled “Fetal Exposure to Chlordane and Permethrin Mixtures in Relation to […]

(Beyond Pesticides, July 5, 2011) Recent findings add to a growing body of evidence that persistent organic pollutants (POPs) might drive changes in the body that lead to diabetes, researchers say. A new study finds that environmental exposure to some POPs substantially increased risk of future type 2 diabetes in an elderly population. POPs are lipophilic (fat-loving) chemicals that accumulate mainly in adipose tissue and have recently been linked to type 2 diabetes. This current study, “Polychlorinated Biphenyls and Organochlorine Pesticides in Plasma Predict Development of Type 2 Diabetes in the Elderly: The Prospective Investigation of the Vasculature in Uppsala Seniors (PIVUS) Study,” sought to follow up on previous findings that had linked these chemicals with type 2 diabetes and was performed to evaluate prospective associations of type 2 diabetes with selected POPs among the elderly. The team recruited a group of 725 diabetes-free elderly adults in Sweden and took blood samples to measure their levels of the pollutants. Then, the researchers followed them for the next five years. Thirty-six of the study participants were diagnosed with type 2 diabetes over that time. Nineteen POPs (14 polychlorinated biphenyl [PCB] congeners, 3 organochlorine pesticides1 brominated diphenyl ether, and 1 dioxin) were […]