(Beyond Pesticides, August 20, 2015) Just as children go  back to school, research  finds that lice in 25 of 30 states in a  U.S. study have developed resistance to common over-the-counter treatments like permethrin, calling into questions the justification for exposing children to a neurotoxic and carcinogenic pesticide and elevating the need to consider nontoxic alternatives. The  research was presented Tuesday at the 250th National Meeting and Exposition of the American Chemical Society (ACS), by Kyong Yoon, Ph.D., of Southern Illinois University, Edwardsville. Classified as a synthetic pyrethroid insecticide, permethrin is “likely carcinogenic” and a suspected endocrine disruptor, immunotoxic, neurotoxic, and highly toxic to fish, aquatic animals, and bees. Dr. Yoon and his colleagues describe the threefold mutations that lice have developed over time due to the constant use of synthetic pyrethroid insecticides. This new finding builds on his team’s previous research, which found that 99.6% of lice are resistant to chemical treatment, adding weight to the fact that chemical treatments not only are unnecessary given effective least-toxic alternatives, but also are not able to provide the lice control that manufacturers claim. “We are the first group to collect lice samples from a large number of populations across the U.S.,” […]

(Beyond Pesticides, June 24, 2015) The International Agency for Research on Cancer (IARC) has found that there is some evidence in experimental animals that the popular herbicide, 2,4-D, is linked to cancer and now classifies it as a Group 2B, “possibly carcinogenic to humans.” IARC also classified lindane, used commonly in the U.S. as a topical lice treatment, in Group 1,“carcinogenic to humans” based on sufficient evidence in humans with the onset of non-Hodgkin lymphoma (NHL). These latest cancer findings come just months after the agency classified the world’s most widely used herbicide, glyphosate (Roundup), as “probably carcinogenic to humans,” raising public concerns on the lack of action from U.S. regulators. This month, 26 experts from 13 countries met at the World Health Organization’s (WHO) IARC in Lyon, France to assess the carcinogenicity of the insecticide lindane, the herbicide 2,4-D, and insecticide DDT. The findings are published in the Lancet. The new IARC findings come months after the agency classified glyphosate, the ingredient in the popular Roundup weed killer, as a Group 2A “probable” carcinogen, citing sufficient evidence of carcinogenicity based on laboratory studies. This decision sparked renewed calls for the U.S. Environmental Protection Agency (EPA) to take action on […]

(Beyond Pesticides, June 19, 2015) A new study directly links exposure to dichlorodiphenyltrichloroethane (DDT) in utero to the development of breast cancer later in life. Published in the Journal of Clinical Endocrinology and Metabolism, the study looked at data that were taken from a California program that  evaluated  samples from women during 1960s, when DDT use was popular. DDT is known to be an endocrine disruptor, and is linked to serious health effects. Although DDT has been banned for many years, residues still linger in certain areas of the U.S. and continue to cause environmental and health hazards. The recent study, titled DDT Exposure in Utero and Breast Cancer,  focuses on 118 mothers who were members of Kaiser Foundation Health Plan from 1959-1967 and had daughters that were diagnosed with breast cancer by their 50s. Stored blood samples from these mothers gave researchers an idea of how much DDT they were exposed to during pregnancy or soon after giving birth. They found that elevated levels of DDT in the mother’s blood led to a four-fold increase in the daughter’s risk of developing breast cancer. Among those with cancer, 83% had a form of cancer called estrogen positive breast cancer, which […]

(Beyond Pesticides, April 1, 2015) According to a new study from Harvard University researchers, eating fruit and vegetables containing pesticide residues adversely affect men’s fertility, leading to fewer and poorer quality sperm. The study, published online in the journal,  Human Reproduction, adds to a growing body of research that finds pesticide exposures give rise to impaired reproductive function, including reduced sperm counts, sperm quality and reduced fertility in exposed men. The results of this study also underscore the importance of an organic diet in reducing pesticide exposures. The study, “Fruit and vegetable intake and their pesticide residues in relation to semen quality among men from a fertility clinic,” believed to be the first to  look into the consumption of fruits and vegetables with high levels of pesticide residue in relation to semen quality, and conducted by researchers at Harvard University’s TH Chan School of Public Health, found that men who ate the greatest amount of fruit and vegetables with high levels of pesticide residue had a 49% lower sperm count and a 32% fewer normally formed sperm than those who consumed the least. Jorge Chavarro, MD, assistant professor of nutrition and epidemiology and co-author of the study, said, “We found […]

(Beyond Pesticides, March 13, 2015) Exposure to endocrine (hormone) disrupting chemicals (EDC) results in approximately € 150 billion ($162 billion) in health care costs in the European Union each year, according to panels of scientists tasked by the EU Commission to study their impact. “The shocking thing is that the major component of that cost is related to the loss of brain function in the next generation,” Philippe Grandjean, M.D. of Harvard University, one of the report’s authors, told the Guardian. EDCs, contained in common household products such as detergents, disinfectants, furniture, plastics, and pesticides, interfere with the body’s hormone system either by mimicking naturally produced hormones, blocking hormone receptors in cells, or effecting the transport, synthesis, metabolism or excretion of hormones. These impacts can result in devastating effects on one’s health, including behavioral and learning disorders, such as Attention Deficit Hyperactivity Disorder (ADHD), birth defects, obesity, early puberty, infertility, cardiovascular disease, and childhood and adult cancers. Nearly 100 percent of people have detectable amounts of EDCs in their bodies, according to the introductory guide to EDCs published by the Endocrine Society and IPEN. “Our brains need particular hormones to develop normally —the thyroid hormone and sex hormones like testosterone […]

(Beyond Pesticides, January 30, 2015) Extensive exposure to common chemicals may be linked to an earlier start of menopause, according to a new study out of Washington University School of Medicine in St. Louis. Researchers of the study found that women whose bodies have high levels of these chemicals, including three pesticides, experience menopause two to four years earlier than women with lower levels of the chemicals. The pesticides found to have a significant correlation with an early start in menopause were p,p’-DDE (a metabolite of DDT), β-hexachlorocyclohexane (a byproduct of the production of lindane), and mirex. All three pesticides are organochlorine insecticides or their breakdown products that have been banned for use  in the U.S., but continue to persist in the environment and in the food chain. The study, Persistent Organic Pollutants and Early Menopause in U.S. Women, published this week in the journal PLoS ONE, investigates the link between levels in blood and urine of 111 endocrine-disrupting chemicals (EDCs), or chemicals that interfere with the body’s hormonal activity, and focused on known reproductive toxicants or persistent environmental contaminants. The findings suggest a significant association between 15 chemicals —nine polychlorinated biphenyls (PCBs, which are industrial products), three pesticides, two […]

(Beyond Pesticides, November 4, 2014) Last week, a United Nations committee of experts recommended the global elimination of the pesticide pentachlorophenol (PCP), widely used in the United States and elsewhere for treatment of wooden utility poles and railroad ties. Scientists cite chemical’s persistence, bioaccumulation, long-range transport, and PCP’s toxic impacts in recommending it being listed in  the Stockholm Convention on Persistent Organic Pollutants, an  international treaty established to safeguard human and environmental health from highly hazardous chemicals. The committee further noted the wide availability of non-chemical alternatives much safer than PCP, which include steel, composite,  and concrete poles, as well as the burying of power lines. “This is the beginning of the end of pentachlorophenol,” said Pam Miller, executive director of Alaska Community Action on Toxics. “Pentachlorophenol has global health implications since it is found in the bodies of people throughout the world including Indigenous Peoples of the Arctic. Now governments and the private sector need to get to work to finally eliminate this toxic chemical.” The United States is not a signatory to the Stockholm Convention, and is, in fact, the largest producer and user of PCP in the world. U.S. government agencies have sent mixed messages during  the […]

(Beyond Pesticides, October 15, 2014) A new study published in Environmental Health Perspectives finds a strong relationship between the use of pesticides and depression in farmers. One specific class of pesticide, organochlorines, was associated with a 90% higher chance of being diagnosed with depression. For fumigants, the increased risk was up to 80 percent. This study echoes the conclusion from an earlier French study which also reported that farmers using pesticides face  a greater risk of developing depression. The study, Pesticide Exposure and Depression among Male Private Pesticide Applicators in the Agricultural Health Study, examines possible associations between pesticide exposure and depression among male private pesticide applicators in the Agricultural Health Study (AHS). Over 21,000 applicators who enrolled in the study in 1993—1997 were followed and examined. The applicators were asked about depression when enrolled in the study and then again around 2010. Previous work with this AHS sample found a higher prevalence of depression among male applicators who reported past pesticide poisoning or use of pesticides from several different classes. However, this study examines specific pesticides, and finds that two types of pesticides, fumigants and organochlorine insecticides are positively correlated with depression and cumulative days of use. Those exposed […]

(Beyond Pesticides, August 7, 2014) Residents of St. Louis, Michigan aren’t used to seeing large excavators and dump trucks haul piles of dirt from their front yards or entire blocks of big, neighborhood trees felled. What they are used to seeing are dead birds ””sometimes even spontaneous, mid-flight deaths of the birds”” and because of a toxic series of events, disasters, and delays spanning decades, the two sights are inextricably connected. As one St. Louis resident described to the Detroit Free Press, dozens of dead robins and blackbirds had been collected from her backyard in the 18 years she has lived there, with the most recent just a couple weeks ago. This experience and other similar stories from the area prompted researchers at Michigan State University (MSU) to start figuratively and literally digging. Matt Zwiernik, Ph.D., an environmental toxicologist at MSU, and volunteers collected 29 dead birds, including 22 robins, last year from a nine-block residential area in St. Louis. The scientific sampling was only a small portion of the dead birds they could have collected, Dr. Zwiernik explained to reporters at the Detroit Free Press, as time, distance, logistics, and access to property sometimes limited collection efforts. Nevertheless, it […]

(Beyond Pesticides, August 5, 2014) A new study finds that female mice exposed in utero to the pesticide DDT are at greater risk for obesity and type-2 diabetes, adding to a growing body of literature linking metabolic diseases to pesticide exposure. The study, titled Perinatal Exposure of Mice to the Pesticide DDT Impairs Energy Expenditure and Metabolism in Adult Female Offspring, was published in the journal PLoS One. Researchers measure and compare metabolic abnormalities in female mice that were exposed in utero to DDT against a control group of those that were unexposed. After exposure, the two groups were then fed high-fat diets for 12 weeks in adulthood. Females exposed to DDT around the time of their birth were more likely to develop insulin sensitivity, glucose intolerance, high cholesterol, and metabolic complications that could result in liver disease. These results suggest that DDT exposure in and around the time of gestation cultivates conditions that increase an individual’s likelihood of accumulating excess fat over the course of one’s lifespan. Additionally, the results find that changes in the way fats and carbohydrates are metabolized can increase the risk of developing metabolic syndrome, which is a precursor to type-2 diabetes. The researchers’ observations […]

(Beyond Pesticides, July 28, 2014) New research from Michael Skinner, Ph.D.’s laboratory out of Washington State University finds that —yet again”” exposure to pesticides may have devastating consequences for future generations. The study, “Pesticide Methoxychlor Promotes the Epigenetic Transgenerational Inheritance of Adult-Onset Disease through the Female Germline,” published in PLOS ONE, finds that gestating rats exposed to the pesticide methoxychlor develop a higher incidence of kidney disease, ovary disease and obesity in offspring spanning three generations. The incidence of multiple diseases increased in the third generation or “great-grandchildren.” This study suggests that ancestral exposures to methoxychlor over the past 50 years in North America may play a part in today’s increasing rates of obesity and disease. The epigenetic changes observed were specific to methoxychlor exposure and, according to researchers, may prove to be valuable biomarkers for future research on transgenerational disease. For people exposed to the pesticide, Dr. Skinner says his findings have implications such as reduced fertility, increased adult onset disease and the potential to pass on those conditions to subsequent generations. “What your great-grandmother was exposed to during pregnancy, like the pesticide methoxychlor, may promote a dramatic increase in your susceptibility to develop disease, and you will pass […]

(Beyond Pesticides, July 11, 2014) In addition to previous research on the direct impacts of pesticides on pollinators and other beneficials, a recent study published by Dutch scientists establishes an additional indirect link between neonicotinoid use and insect-eating birds. The report, which came out on Wednesday, provides evidence that neonicotinoids, a class of systemic pesticides, are indirectly hurting larger creatures by reducing insect prey populations such as mosquitoes and beetles. Researchers found that in certain areas of the Netherlands where water is contaminated with high concentrations of imidacloprid, a commonly used neonicotinoid, bird populations tend to decline by an average of 3.5 percent every year. Further analysis found that this spatial pattern of decline appeared only after the introduction of imidacloprid to the Netherlands in the mid-1990s, even after correcting for land-use changes that have been known to affect bird populations in farmland. “To our surprise we did find a very strong effect on birds”, said lead author of the study, Caspar Hallmann, a Ph.D. student from Radboud University in the Netherlands, to Reuters. In fact, according to the study, which was published in the journal Nature, nine of 15 bird species studied only eat insects and all feed insects […]

(Beyond Pesticides, July 2, 2014) According to a new study, few obstetricians offer their pregnant  patients advice on how to avoid environmental toxins that might harm their babies, even though doctors recognize that exposure to chemicals like pesticides, bisphenol-A (BPA), and metals can affect  a pregnancy. The study recommends that the medical community improve medical education and training, develop recommendations for prevention and less toxic alternatives, as well as lend support to policy change. The first of its kind study of prenatal counselling, published in the journal  PLOS ONE, Counseling Patients on Preventing Prenatal Environmental Exposures – A Mixed-Methods Study of Obstetricians, found that U.S. obstetricians and gynaecologists feel they lack the medical education and training, and evidence-based guidelines and tools for communicating potential environmental risks to patients. Exposure to environmental toxins, the researchers from the University of California, San Francisco (UCSF) found, is rarely discussed with pregnant patients, even though a national survey shows that 80 percent of physicians agree they should play a part in reducing patients’ exposure to toxins. But, of the 2,500 respondents, only one in five routinely asked  their  patients about these exposures, and just one in 15 said they received training on the harmful […]

(Beyond Pesticides, June 30, 2014) Decades later there are still horrifying impacts from a legacy of dumping in the environment tens of thousands of pounds of chemical waste used in the production of pesticides. The production  by the Hooker Chemical Company of C-56, the progenitor of many now banned organochlorine pesticides, has resulted in contamination and hardship. Beyond Pesticides has long advocated for the elimination of hazardous synthetic pesticides, due to unnecessary risks that put the health of both people and entire communities in jeopardy. Long after the Depression Era in Montague, MI, there were still many families who were left jobless and looking for any means to bring back a better life. The town decided to stimulate the local economy by recruiting Hooker Electrochemical Company; a chemical manufacturer originally based in New York, where it had been using an old canal bed for disposal of waste in the 1940s and was looking for a new site to build a chlor-alkali plant. Ninety-six percent of local residents signed the petition to bring them in. The situation was perfect for Hooker, which needed the vast underground reserves of salt and the lake water in the town for cooling during its industrial […]

(Beyond Pesticides, March 21, 2014) Banned pesticides and flame retardants may be the cause of higher autistic behaviors for children who were exposed in utero, according to new research published last week in the journal Environmental Health Perspectives. Previous research has demonstrated that organochlorine chemicals are linked to learning problems, such as attention-deficit hyperactivity disorder (ADHD), especially in boys. This research is one of the first studies to evaluate their contribution to autistic behaviors. According to the study, Gestational Exposure to Endocrine-Disrupting Chemicals and Reciprocal Social, Repetitive, and Stereotypic Behaviors in 4- and 5-Year Old Children, children who were exposed to higher levels of brominated flame retardant PBDE-28 and trans-nonachlor, a component of the banned pesticide chlordane, scored higher in terms of autistic behavioral patterns as ranked by their mothers. In the study, researchers conducted a case-cohort study recruiting 175 pregnant women from seven prenatal clinics within the greater Cincinnati, Ohio region who provided urine and blood samples during pregnancy to measure the concentration of endocrine disrupting chemicals. On average, pregnant women had 44 suspected hormone disrupting chemicals. Five years later, when children had turned four or five, mothers were asked to rank their children’s behavior based on a series […]

(Beyond Pesticides, November 13, 2013) As the world sheds tears from reading the reports of human suffering and looks on in horror at the pictures of devastation caused by Typhoon Haiyan, the debate of whether increased occurrences of super-storms like Haiyan are just over the horizon because of man-made climate change have also taken up residence in the headlines. Coupled by coverage of the 19th session of the Conference of the Parties to the U.N. Framework Convention on Climate Change and the leak of a draft summary of the Intergovernmental Panel on Climate Change’s latest report on the impacts of global warming, the world is clearly paying attention. As the wide array of demonstrated effects and impacts of climate change are discussed on the world stage and world leaders attempt, once again, to create a meaningful plan to mitigate risks and even potentially avoid some of the most extreme threats, an important and even more deadly consequence of climate change lurks in the background: increased toxic chemical exposure. In a collection of studies and scientific reviews released earlier this year in Environmental Toxicology and Chemistry, scientists investigated a wide range of global climate change issues and toxicological impacts on the […]

(Beyond Pesticides, November 7, 2013) A study released this week established a strong connection between endometriosis and exposure to two dangerous pesticides: lindane and mirex. While the results are not surprising given past connections between these pesticides and their endocrine-disrupting effects, this new study, Organochlorine Pesticides and Risk of Endometriosis: Findings from a Population-Based Case-Control Study, is one of the first to examine the association between organochlorine pesticides (OCPs) and endometriosis, one of the most common gynecological diseases, in women in the general population. The study’s authors, Kristen Upson, Ph.D. et al,  explained to Environmental Health Perspectives, “Our study suggests that exposure from extensive past use of environmentally persistent OCPs in the United States, or present use in other countries may impact the health of the current generation of reproductive-age women with regard to a hormonally-mediated disease.” In conducting the study, researchers selected a group of women with surgically-confirmed cases of endometriosis from the greater Pacific Northwest area. This group of women was then divided into four groups, based on the level of pesticide in each woman’s blood. Women in the second-highest exposure group for beta-hexacyclochlorohexane (beta-HCH), a byproduct of lindane, had a 70 percent greater risk of endometriosis than […]

(Beyond Pesticides, October 28, 2013) Scientists at Washington State University (WSU), in a laboratory study,  determined that exposure to the insecticide DDT ””banned in the U.S. since 1972, but still used today in developing countries for malaria abatement programs””impacts multiple generations, ultimately contributing to obesity three generations down the line. The study, published in the journal BMC Medicine, provides the scientific community with new information on multi-generational impacts of pesticide exposure. Lead researcher Michael Skinner, PhD., professor of biological sciences at WSU, and colleagues exposed pregnant rats to DDT to determine the long-term impacts to health across generations. The study, Ancestral dichlorodiphenyltrichloroethane (DDT) exposure promotes epigenetic transgenerational inheritance of obesity, finds that the first generation of rats’ offspring developed severe health problems, ranging from kidney disease, prostate disease, and ovary disease, to tumor development. Interestingly, by the third generation more than half of the rats have increased levels of weight gain and fat storage. In other words, the great grandchildren of the exposed rats are much more likely to be obese. “Therefore, your ancestors’ environmental exposures may influence your disease development even though you have never had a direct exposure,” the study finds. Previous studies have demonstrated that exposure to […]

(Beyond Pesticides, October, 16 2013)   Researchers at the Illinois Department of Natural Resources and the University of Illinois Urbana—Champaign have found that organochlorine pesticides and other organochlorine compounds like polychlorinated biphenyls (PBCs) are still contaminating river otters in the state, even though these chemicals have been banned for decades. Surprisingly, the levels detected are the same or higher than those detected in otters 20 years ago, highlighting the need to understand the exposure of wildlife and humans to organochlorine compounds despite their ban. In order to see what chemicals might be affecting otters, if any, the researchers examined the bodies of 23 river otters collected between 2009 and 2011. In the published study, River otters as biomonitors for organochlorine pesticides, PCBs, and PBDEs in Illinois,  scientists looked at liver concentrations of 20 organohalogenated compounds once used in agriculture and industry. The average concentrations of dieldrin, an insecticide that was used across the Midwest before being banned in 1987, actually exceeded those measured in river otters collected from 1984 to 1989. Liver concentrations of PCBs and DDE -a breakdown product of the banned DDT – were also similar to those in an earlier study showing that contamination has not decreased […]

(Beyond Pesticides, September 18, 2013) DDT, a pesticide banned in 1972, is behind the mystery surrounding the reproductive problems of dozens of endangered condors. This is according to a peer-reviewed paper written by 10 condor experts, including biologists from the Los Angeles and Santa Barbara zoos and the U.S. Fish and Wildlife Service. The researchers, who spent six years studying the reproductive problems, including eggshell thinning, in California condors have “established a strong link” to DDT in the birds’ food source. Condors are large scavenger birds with wingspans up to 10 feet and were reintroduced to California’s coast in 1997 after a century-long population decline. However, in 2006 biologists began observing thinning shells in many condor nests. Over the next six years, scientists observed condors feeding on dozens of sea lions, and found that in Big Sur, California, condor populations had low hatching success ”” just 20-40 percent. In contrast, 70-80 percent of southern California condors in the Tejon area had hatched successfully over the same time. The southern California condors are inland, and sea lions are not a food source. According to the study published in the journal, The Condor, the outer crystalline layer of shells was absent or […]

(Beyond Pesticides, August 30, 2013) Months after Central American health ministries issued a  joint declaration citing kidney disease as a top public health priority, the World Bank just approved a new loan to expand sugar cane plantations in Nicaragua. The Bank’s loan represents renewed support for an industry whose workers have been devastated by the disease, which has increasingly been linked to pesticide exposure and exacerbated by heat stress. Kidney disease afflicts agricultural workers in sugar cane fields, killing thousands each year in Central America as well as in Sri Lanka and India. Scientists have yet to definitively uncover the cause of chronic kidney disease (CKD), although emerging research points to toxic heavy metals contained in pesticides as one of the primary culprits. CKD is a condition characterized by a gradual loss of kidney function and is often lethal for poor agricultural workers. As the kidneys begin to fail, wastes can build in the blood causing complications such as high blood pressure, anemia, weak bones, poor nutritional health and nerve damage. Several published studies demonstrate that exposure to certain  organochlorine pesticide products and their heavy metal contaminants used on sugar cane plantations are causally linked to CKD. The recent joint […]

(Beyond Pesticides, June 26, 2013) Pesticide use has sharply reduced the regional biodiversity of stream invertebrates, such as mayflies and dragonflies, finds a study published in the Proceedings of the National Academy of Science. While previous research has shown similar decreases in individual streams, this new study analyzes the effects of pesticides over broad regions. This is one of several recent findings that show pesticides pose a long-term threat to important ecosystems. The study, entitled Pesticides reduce regional biodiversity of stream invertebrates, notes that losses of biodiversity caused by anthropogenic activities during the past 50 years are unprecedented in human history. A team of researchers sampled 23 streams in the central plains of Germany, 16 in the western plains of France, and 24 in southern Victoria, Australia. Researchers classified streams according to three different levels of pesticide contamination: uncontaminated, slightly contaminated, and highly contaminated. Utilizing a model-based approach to account for other environmental variables, the team observed that losses in taxonomic diversity were, to a large degree, determined by the loss of species specifically vulnerable to pesticides. Overall, they found that there were up to 42% fewer species in highly contaminated than in uncontaminated streams in Europe. Highly contaminated streams […]

(Beyond Pesticides, April 24, 2013) Using the aquatic species Daphnia, commonly referred to as “water fleas,” scientists at North Carolina State University (NC State) determined that exposure to the pesticide pyriproxyfen impacted multiple generations, ultimately resulting in more male offspring, and causing reproductive problems in female offspring. Lead author Gerald LeBlanc, PhD, notes, “This work supports the hypothesis that exposure to some environmental chemicals during sensitive periods of development can cause significant health problems for those organisms later in life —and affect their offspring and, possibly, their offspring’s offspring.” The study, published in the journal PLoS One, provides the scientific community with new information on how organisms respond to the environmental signals resulting from pesticide exposure. Environmental cues normally determine whether the Daphina offspring will be male or female, according to the researchers. This study is part of an investigation to understand the mechanisms involved with these environmental cues. The NC State team had previously identified the hormone methyl farnesoate (Mf) as an important factor in determining the sex of the organisms at the embryotic stage. The scientists exposed Daphnia to varying levels of the pesticide pyriproxyfen, an insecticide that mimics the Mf hormone. The exposure resulted in Daphnia producing […]