(Beyond Pesticides, October 24, 2019) Fish and fruit are undoubtedly healthy foods, but modern-day contamination is leading scientists to caution pregnant mothers and young children to stick within current dietary guidelines, or switch to organic, in order to avoid adverse health effects. This new public health message is based on research published in the journal Environmental Health Perspectives by scientists from University of Southern California (USC) and several European Countries, finding that overconsumption of fish and fruits leads to higher levels of contamination with toxic persistent chemicals. “During gestation and early development, the fetus and the child, respectively, are vulnerable to the effects of environmental chemicals, said Lida Chatzi, MD, associate professor of preventive medicine at the Keck School of Medicine of USC. “A balanced diet during these periods is also critical for optimal nutritional status, but what to eat, and how much, are critical questions.” Scientists studied a cohort of 1,288 children (between 6 and 11 years) and 818 pregnant mothers from six European countries, who were provided questionnaires to assess their weekly diet. Blood levels of a range of environmental toxicants, including organochlorine compounds like PCB, PFHSs, PFOS, PFOA, pesticides like DDT and DDE, and heavy metals including […]

(Beyond Pesticides, October 7, 2019) Central American agricultural workers, exposed in the 1970s and early 1980s to a highly toxic pesticide, subsequently began suing manufacturers in the mid-1980s, with mixed success. Now, some of those workers have stepped up their game: they have brought suit against three big agrochemical industries in France to try to recover hundreds of millions of dollars in damages awarded to them by Nicaraguan courts, but never paid. As reported by The New York Times, “the case could set a legal precedent and lead to more lawsuits in France for harm done in other countries by the pesticide Nemagon.” Farmworkers in Nicaragua, Guatemala, Costa Rica, Ecuador, Panama, the Philippines, West Africa, and the U.S. were exposed to the highly toxic, brominated organochlorine pesticide ingredient, DBCP (dibromochloropropane), from the 1960s until cessation of its use, which has varied from country to country. DBCP was sold in the pesticide products Nemagon and Fumazone as a soil fumigant and nematocide on banana plantations and other crops across Central America (especially), in western Africa, and in Hawaii. As acknowledged by the Environmental Protection Agency (EPA), DBCP has multiple adverse health impacts: decreased sperm production and mobility, disturbed estrous cycles, reduced phagocytosis […]

(Beyond Pesticides, October 2, 2019) New data gleaned from the Kuakini Honolulu Heart Program — a longitudinal study of men of Japanese descent living on Oahu — demonstrate that occupational exposure to high levels of pesticides can increase risks for cardiovascular disease (CVD) in the forms of coronary heart disease (CHD) or stroke (CVA, or cerebrovascular accident). Further, researchers determined both that workers who experience high-level exposures may not experience such effects for years afterward, and that the maximum subsequent effects were seen within a decade of exposure. The study’s conclusion highlights the importance of pesticide applicator use of protective gear when handling toxic pesticides. These risks and harms could be eliminated through a transition to non-chemical means for pest control in agriculture, land management, and home and personal practices. The Kuakini Honolulu Heart Program, after enrolling more than 8,000 Japanese-American men, 45–68 years old and living on Oahu, Hawaii between 1965 and 1968, has continued to examine and interview these subjects, and document morbidity and mortality among them. This study, which performed statistical analyses on 7,557 of the subjects, is the longest longitudinal study of cardiovascular disease and any association with chronic occupational pesticide exposure, taking into account epidemiologic risk […]

(Beyond Pesticides, September 24, 2019) “Over increasingly large areas of the United States, spring now comes unheralded by the return of the birds, and the early mornings are strangely silent where once they were filled with the beauty of bird song,” Rachel Carson wrote in Silent Spring in 1962. New research finds that quote has held true since it was written. Over three billion birds, or 29% of 1970s abundance have been lost in North America over the last 50 years. To make these dismal determinations, scientists drew from multiple long-term bird monitoring datasets, and a network of nearly 150 weather radars that pick up and thus have recorded the trajectory of migratory birds. Long-term surveys helped scientists determine the 3 billion bird decline, while satellite data found that migratory bird abundance has declined by 9.1% since 2007. In general, 57% of bird species are in decline, with showing the largest loss. Ninety percent of all declines were within 12 bird families: American sparrows, warblers, blackbirds, larks, Old world sparrows, swallows, nightjars, swifts, finches, flycatchers, starlings, and thrushes. Only waterfowl and wetland bird species showed any increase, 13% and 56%, respectively. Ducks, geese, and raptors all improved population levels more […]

(Beyond Pesticides, July 9, 2019) Teens and adolescents living in agricultural areas and exposed to organophosphate insecticides are at higher risk of depression, according to the findings of a new study in the International Journal of Hygiene and Environmental Health. As rates of depression and suicide rise for teenagers in the US and throughout the world, public health researchers are working to find out why by investigating potential triggers. Toxic pesticide use represents a risk that can be addressed head on, protecting children and their families from a range of diseases that threaten public health. Jose R. Suarez-Lopez, MD, PhD, at the University of California San Diego School of Medicine, has been studying children living in the Ecuadorian Andes since 2008. His team assessed 529 individuals aged between 11 and 17 for their blood levels of acetylcholinesterase (AChE), an enzyme necessary for the proper functioning of nerves in the body. Exposure to organophosphate insecticides like chlorpyrifos and malathion have been shown to lower levels of AChE in the body. An assessment was also given to the children to fill out, in order to determine the severity of depressive symptoms or anxiety. Results showed that children with lower levels of AChE […]

(Beyond Pesticides, April 26, 2019) Research by the youth participatory action team of the CHAMACOS of the Salinas Evaluating Chemicals in Homes and Agriculture (COSECHA) reveals that teenagers in the Salinas Valley, California are routinely exposed to concerning levels of multiple toxic pesticides, several of them known endocrine disruptors. In an interview with Kion News, COSECHA research director Kimberly Parra remarked that the study is especially important because teenagers are in a stage of rapid reproductive development. As the study authors emphasize, it is their developmental stage that makes teenagers more vulnerable to the effects of endocrine disrupting pesticides, with potentially devastating consequences for lifelong health. The COSECHA study quantifies exposure to 72 pesticides, captured through volatile-trapping silicone wristbands, across 97 teenage girls living in various areas of the Salinas Valley region. Of the 72 pesticides analyzed, authors report that subjects are exposed to as many as 20 and an average of 8 pesticides over one week of routine indoor and outdoor activity. Given the well-documented dangers of pesticide co-exposures, these multiple-exposure findings are particularly concerning. Ranking the highest for prevalence among the studied pesticides is fipronil sulfide, a breakdown product of the insecticide fipronil, detected in 86.6% of the analyzed wristbands. […]

(Beyond Pesticides, April 8, 2019) Officials in Europe and the U.S. focus on banning problem pesticides, raising concerns about their replacements in the face of pesticide-intensive management strategies, while organic advocates call for a systems change in land management. In reference to widespread community bans of Roundup/glyphosate, Cary Gillam, author of Whitewash, told last year’s Beyond Pesticides’ Forum, “Glyphosate is the poster child for the bigger pesticide problem.” She continues, “If it goes away tomorrow, we are not okay.” Because of this, Beyond Pesticides has strategically sought to transform our country’s approach to pest management, both agricultural and residential/structural, by eliminating a reliance on pesticides and advancing organic management practices that do not rely on toxic inputs. This Daily News Blog post offers updates on progress in the European Union (EU), in the U.S. Congress, and in communities and sates nationwide. The EU is poised to ban clorothalanil, a commonly used — and highly toxic — organochlorine fungicide, The Guardian reported, in mid-to-late May 2019. After a review by the European Food Safety Authority (EFSA), EU states voted to approve a ban. EFSA identified as a chief safety concern the possibility that breakdown products (metabolites) of the compound may cause damage […]

(Beyond Pesticides, March 26, 2019) In a study investigating the carcinogenic effects of pesticide exposure by analyzing data on 316,270 farmers and farmworkers in the U.S., Norway, and France, researchers have identified elevated risk for non Hodgkin lymphoma (NHL) and some subtypes, linking glyphosate and large B-cell lymphoma. Other pesticides linked to the disease include the pyrethroid deltamethrin and chronic lymphocytic leukemia/small lymphocytic lymphoma; and terbufos and NHL overall. Researchers also found “inverse associations of NHL overall with the broader groups of organochlorine insecticides and phenoxy herbicides, after adjusting for exposure to other pesticides”; such inverse associations were not found with active ingredients within these groups. The research underscores how complex the science of pesticide impacts on human health, and on cancer incidence, can be. To wit: in evaluating 14 different pesticide categories and 33 individual, active chemical ingredients, Maria E. Leon, et al., conclude that associations of pesticides with the development of NHL appear to be (NHL) subtype- and chemical-specific. Published in the International Journal of Epidemiology in mid-March, the study, “Pesticide use and risk of non-Hodgkin lymphoid malignancies in agricultural cohorts from France, Norway and the USA: a pooled analysis from the AGRICOH consortium,” uses data from three large cohort […]

(Beyond Pesticides, March 1, 2019) The costs of pesticide use extend far beyond the invoices farmers pay for purchase of the chemicals to use on their crops. The real costs related to pesticide use and exposure include those of health care, lost productivity and income, and environmental damage (loss of environmental services and biodiversity; compromised air, water, and soil quality). There has been relatively little research focused on those real and extensive costs; this Daily News Blog turns its attention to several that have made the attempt. January 2019 saw the publication of a new book, Sicker Fatter Poorer: The Urgent Threat of Hormone-Disrupting Chemicals to Our Health and Future … and What We Can Do About It, by Leonardo Trasande, MD, MPP, which examines how some chemicals — including organophosphate and organochlorine pesticides — disrupt human endocrine (hormonal) function, and damage health, sometimes irreparably. The book further investigates the economic costs of associated diseases and other health problems to the U.S. economy — on the order of 2.3% of GDP (gross domestic product), or $340 billion, annually. As Dr. Trasande notes, “The reality is that policy predicts exposure, exposure predicts disease and disease ultimately costs our economy.” Dr. Trasande is […]

(Beyond Pesticides, January, 23, 2019) Individuals that have been acutely poisoned by pesticides at some time in their life may be more likely to lose their sense of smell, according to a recent study published in Environmental Health Perspectives.  Researchers focused on the effect of high pesticide exposure events (HPEE), such as a pesticide spill or other incident, on a farmers’ ability to smell later in life. This is the first study to indicate pesticide exposure may result in olfactory impairment. Farmers from Iowa and North Carolina enrolled in an ongoing U.S. Agricultural Health Study have been asked about their pesticide use roughly every 5 to 6 years since 1993. In the most recent survey, taken from 2013-2015, farmers were asked additional questions about HPEE in their lifetime and whether they had a significantly decreased or impaired sense of smell. “Studying farmers gives us more reliable data on pesticide exposures than if we had studied the general population,” says Honglei Chen, MD, PhD, lead author and professor of epidemiology at Michigan State University in a press release. “Because they use pesticides more and it’s part of their job, they’re more likely to remember what pesticides they used and in cases […]

(Beyond Pesticides, December 17, 2018) Cardiovascular disease is a major cause of poor health and mortality across the world. Much is known about congenital and behavioral contributors to the disease, yet to date, little research has focused on potential environmental factors, including the possible contribution to cardiovascular disease (CVD) of exposures to toxic chemicals in the workplace. A recent study of CVD incidence among Hispanic and Latino workers, by Catherine Bulka, PhD, et al., has evaluated associations of self-reported exposures to organic solvents, metals, and pesticides with CVD. The study was published in the journal Heart on December 11, 2018, and is first to evaluate the role of chemical exposures in the workplace in the incidence of CVD in this demographic sector. As do many scientific investigations, this one points to a need for further study of the links that emerged between such exposures and compromised cardiovascular health. In an editorial in that same issue of Heart, commenting on the study, Dr. Karin Broberg of the Karolinska Institutet in Stockholm, Sweden, noted that “exposure to metals and pesticides is common worldwide, and this study highlights the need to better understand the risks that these exposures cause, and to limit exposure in the […]

(Beyond Pesticides, December 11, 2018) Meltwater and runoff from Alaskan glaciers contain detectable levels of organochlorine pesticides that bioconcentrate in fish and put individuals at risk, according to a new study from researchers at the University of Maine (UMaine). DDT, lindane, and other organochlorines have been detected throughout the world, even in natural areas thought to be untouched, and pristine. As UMaine scientists show, the atmospheric transport and ubiquitous deposition of these pesticides continues to pose risks to U.S. residents long after regulations banned their use. Although most of the highly toxic class of organochlorine pesticides like DDT were banned in the early 1970s, some chemicals retained certain uses. Lindane, for example, had its pest management uses phased out gradually until 2007, but is still allowed today as a scabies and lice shampoo. While use of these pesticides has declined in the U.S., much of the developing world, including many Asian countries, such as China, India, and North Korea, still report use. This results in atmospheric transport of the pesticides, and relevant to the UMaine research, increases the likelihood that the chemicals will eventually be deposited onto Alaskan glaciers through snow or rain. The UMaine research team investigated the amount of […]

(Beyond Pesticides, November 9, 2018) A Tunisian study (published in January 2018) on the effects in pre-pubertal mice of exposure to malathion — an organophosphate pesticide first registered for use in the U.S. in 1956 — demonstrates significant distortion of liver and kidney biochemistry and function in the animals. Deleterious effects include compromise of feeding ability, metabolism performance, neurologic deficits, reduction of overall body weight, and simultaneous increases in the weights of livers and kidneys, with structural anomalies and lesions in those organs. Organophosphates (OPs) have raised alarm bells for years. Some, such as chlorpyrifos and diazinon, have had their registrations cancelled for household uses because of the extreme health risks to children, but agricultural, golf course, and “public health” (mosquito control) uses remain commercially available and in use. Recently, Beyond Pesticides reported on research whose investigators support — and called publicly for — a worldwide ban on the compounds because of the serious health and environmental risks they pose, particularly for children. Beyond Pesticides has written extensively on OP pesticides, including malathion and chlorpyrifos. Both are used widely in agriculture. Chlorpyrifos has been the subject of quite a ping-pong match in recent years: a scheduled ban by the Environmental Protection […]

(Beyond Pesticides, October 17, 2018) The unsustainable life cycle management of pesticides during the past seven decades has created huge stockpiles of these (and other toxic) chemicals across much of the globe, including Eastern Europe, Africa, the Middle East, and Latin America. The journal Environmental Science and Pollution Research has published a special series of articles and reports from the International HCH & Pesticides Association (IHPA), titled “The legacy of pesticides and POPs stockpiles — a threat to health and the environment.” Stockpiles have accumulated because some products have been banned for health or environmental reasons, leaving stocks (aka waste) that are often stored inadequately, and which deteriorate and migrate to contaminate the environment and put people at risk. Those affected are very often in poor, rural communities that may be unaware of the threat in their midst. Beyond Pesticides covered this “chemical time bomb” problem in 2004 and again nearly a decade ago. The special issue of Environmental Science and Pollution Research responds to multiple fronts on this problem of accumulation and storage of toxic compounds, identifying the two largest issues as: (1) the stockpile of some 4–7 million tons of hexachlorocyclohexane (HCH) waste from lindane production; and the 240,000 […]

(Beyond Pesticides, September 20, 2018) Babies exposed to higher levels of organochlorine compounds in the womb go on to have worse lung function in childhood, according to new research presented at the European Respiratory Society International Congress. Previous studies have found a link between low lung function in early adulthood and respiratory, cardiovascular, and metabolic issues in later life. Beyond Pesticides has covered in its Daily News studies on a range of adverse effects, including autism in children, caused by organochlorine pesticide exposure, which bioaccumulates in the environment and the human body. Organochlorine compounds, which include the pesticide DDT, as well as electrical insulators and other industrial products, are now banned in most parts of the world. However, because they degrade very slowly, they are still present in the environment and in foods. Previous research has suggests links between exposure to these chemicals in the womb and parents reporting childhood respiratory diseases such as wheezing, asthma, and chest infections. The new study is the first to show a link with objective measures of lung strength and capacity in relation to low-level exposure to these chemicals. Organochlorine compounds can disrupt the hormone system and have been linked to a wide range of […]

(Beyond Pesticides, September 19, 2018) “‘Don’t get pregnant at George Air Force Base’” was the advice imparted from one female Air Force member to another in 1975 at that base, located 100+ miles north of San Diego and used as an active military site from 1941–1992. From the start of their service at George AFB, both parties to this conversation came to be familiar with the shared horror stories of repeated infections, vaginal bleeding, ovarian cysts, uterine tumors, birth defects, and miscarriages among female Air Force members at the site. Many women who served at George AFB in the 1970s, ‘80s, and ‘90s suffered, but did not know what was causing, such health issues, which were frequent enough that even base doctors would sometimes privately warn women off of getting pregnant while serving there. Among the many contaminants found at George AFB and other military sites are organochlorine-based pesticides (OCPs), such as DDT, dieldrin/aldrin, heptachlor, lindane, endrin, chlordane, mirex, toxaphene, hexachlorobenzene, chlordane, and others. (A comprehensive list of OCPs is available here.) Most of these compounds were used on military bases for decades for vegetation control, as building pesticides or fumigants, or for personal pesticide treatments for lice and scabies, and […]

(Beyond Pesticides, August 22, 2018) Mothers with high levels of DDT’s major metabolite, DDE, are more likely to have their children diagnosed with autism, according to a study published in The American Journal of Psychiatry this month. Though this study links autism to long-banned DDT, it raises significant concerns about legacy contamination from this chemical, which remains ubiquitous in the environment and in human bodies. With an increasing number of studies linking autism and other developmental disabilities to pesticides, the need to transition to safer, organic methods of farming is now more important than ever before. The study, Association of Maternal Insecticide Levels With Autism in Offspring From a National Birth Cohort, measured maternal serum levels of Finish women during early pregnancy whose children were born between 1987 and 2005. Specimens were analyzed for DDE as well as PCB contamination. Mothers with DDE at the highest 75% threshold reportedly had a 132% (1.32x odds ratio) increased risk of having a children diagnosed with autism after adjusting for confounders such as age and history of psychiatric disorders. Moms above the 75th percentile had their chances of a child’s autism diagnosis increase by 221% (2.21x odds ratio). The study found no connection […]

(Beyond Pesticides, November 15, 2017) Songbirds exposed to widely used insecticides fail to properly orient themselves for migration, according to a study published by Canadian scientists in Scientific Reports. With the organophosphate chlorpyrifos and the neonicotinoid imidacloprid applied to millions of acres of farmland throughout North America, this new research adds weight to arguments that pesticides are a likely cause in the decline of migratory bird populations. “Studies on the risks of neonicotinoids have often focused on bees that have been experiencing population declines. However, it is not just bees that are being affected by these insecticides,” said Christy Morrissey, PhD, biology professor at the University of Saskatchewan. Researchers captured 57 white crowned sparrows in northern Canada, and held them in an outdoor pen for roughly two weeks, during which time all the birds either gained or maintained their weight. The songbirds were then split into three groups, one exposed to imidacloprid, another to chlorpyrifos, and the last untreated and acting as a control. The imidacloprid and chlorpyrifos exposed groups were each further separated by exposing a portion to the insecticide at 10% of the lethal dose that would kill 50% of a given population (LD50), and another to 25% […]

(Beyond Pesticides, September 14, 2017) Children whose mothers took folic acid while pregnant had a significantly lower risk of developing autism spectrum disorder (ASD) even when their mothers were exposed to household or agricultural pesticides. Researchers at the University of California, Davis found that taking folic acid during the window around conception, reduced the risk of pesticide-induced autism. In the study, “Combined Prenatal Pesticide Exposure and Folic Acid Intake in Relation to Autism Spectrum Disorder,” children whose mothers took 800 or more micrograms of folic acid (the amount in most prenatal vitamins) had a significantly lower risk of developing autism spectrum disorder, even when their mothers were exposed to household or agricultural pesticides that are associated with increased risk. The study used data from the Childhood Autism Risks from Genetics and the Environment (CHARGE) study, where researchers looked at 296 children between 2 and 5 who had been diagnosed with ASD and 220 who had developed typically. Mothers were interviewed about their household pesticide exposure during pregnancy, as well as their folic acid and B vitamin intake. The team also linked data from California Pesticide Use reports, which provided important details about agricultural spraying, with the mothers’ addresses. The results […]

(Beyond Pesticides, September, 2017) A recently released report, Gallup-Sharecare State of Well-Being: The Face of Diabetes in the United States, looks at high diabetes rates across various U.S. demographic groups, including those in farming. People working in the transportation sector registered the highest incidence of diagnosed diabetes at 10.6%. But those working as farmers and fishermen came in second, with 8.5% reporting a diagnosis of the disease. Based on a self-reporting survey, The Face of Diabetes in the United States did not differentiate between Type 1 diabetes (which typically manifests in childhood or young adulthood) and Type 2 diabetes (which commonly emerges in adulthood). It did, however, consider lifestyle risk factors that can influence development of each form of the disease. The “farmer and fisher” folks placed more-or-less in the mid-range among all occupations vis-à-vis several of the lifestyle factors that can impact development of the disease (smoking, diet, and obesity), and a bit higher in alcohol consumption, but in fact, reported more exercise than any other category of worker. These data points would seem to suggest that farmers would be at less risk than those in some other occupational categories. For instance, those working in “installation and repair” reported […]

(Beyond Pesticides, July 27, 2017) Earlier this week U.S. Senators Tom Udall (D-NM) and Richard Blumenthal (D-CT) introduced a bill that would ban use of the insecticide chlorpyrifos. The Protect Children, Farmers and Farmworkers from Nerve Agent Pesticides Act, S. 1624, comes one week after an appeals court refused to require the U.S. Environmental Protection Agency (EPA) to make a decision over whether to ban the chemical. Removing this neurotoxic insecticide from the environment would significantly reduce health risks for children and farmworkers in underserved rural communities, build pressure to address all toxic organophosphates, and help push U.S. agriculture in a more sustainable direction. As with other organophosphate class chemicals, chlorpyrifos, first registered in 1965 by Dow Chemical, is derived from nerve agents used during World War 2. The chemical is linked to a range of negative health and environmental outcomes that warrant its prohibition. Children are at particular risk from the chemical due to their developing immune, organ, and nervous systems.  As with other organophosphate nerve agents, the chemical acts on the body’s nervous system, inhibiting the movement of neurotransmitters called cholinesterase. Chlorpyrifos chemically binds to the site where cholinesterase would in the body, preventing normal nerve impulse transmission. […]

(Beyond Pesticides, February 23, 2017) Male pesticide applicators who experienced a pesticide spill or another related accident are more likely to harbor changes in their DNA associated with an increased risk of prostate cancer, according to a recent paper published in the journal, Environmental and Molecular Mutagenesis. While the relationship between pesticide exposure and prostate cancer is not new, this study adds to the growing body of evidence that high exposure to specific pesticides may lead to the development of prostate and other cancers. The analysis finds that after experiencing one of these exposure events, men are more likely to have higher DNA methylation of a gene linked with an increased risk of developing prostate cancer. DNA methylation is a form of gene regulation that, if disturbed, can result in gene expression changes that can cause cancer. The researchers used data from the ongoing Agricultural Health Study (AHS), which is a long-term cohort study evaluating cancer and other health outcomes of pesticides applicators and their spouses in North Carolina and Iowa. This paper, High pesticide exposure events and DNA methylation among pesticide applicators in the agricultural health study, analyzed a sample size of 596 male pesticide applicators who underwent three phases of […]

(Beyond Pesticides, October 20, 2016) Researchers at the University of Western Australia (UWA) and Murdoch University recently released a study whose findings show that levels of pesticides in breast milk have dropped significantly over the past forty years, though some major concerns remain. Published in the international journal Chemosphere, the research shows a 42-fold decrease in levels of pesticides detected in breast milk, and ties the reduction to government efforts to prohibit persistent organic pollutants (POPs) in Australia, which has lead to decreased exposure over time. Led by UWA’s internationally renowned human lactation researcher Emeritus Professor Peter Hartmann, Dr. Donna Geddes and Murdoch’s Associate Professor Robert Trengove, the study is a testament to the positive impact banning pesticides can have on the health of individuals, especially vulnerable populations like infants, but also shows that there is a long way to go before our bodies are void of any bioaccumulated toxic residues. Researchers often study breast milk because it can bioconcentrate, or accumulate, persistent organic pollutants (POPs). Multiple studies on breast milk have been performed throughout the years, many of them confirming the fact that common toxic chemicals, such as glyphosate and triclosan, build up in our bodies over time. Most […]