(Beyond Pesticides, June 27, 2023) Pesticides interfere with biological processes. This is their purpose. Unfortunately, they nearly always have unintended consequences, many of which have been ignored by their manufacturers. A new review article by Irish and Dutch researchers in the ISME Journal adds to the emerging scientific literature examining how pesticides affect the relationship between the human gut and the human brain (the “gut-brain axis”). Often called the “second brain” because it houses nerve cells and produces neurotransmitters, the gut-brain axis may be the most important locus where microbes and pesticides meet. The human gut plays host to a variety of microorganisms, ranging from bacteria and archaea to fungi, viruses and yeasts.[1] In a healthy person these microbes remain in balance and often cooperate both with each other and with human cells. The gut and the brain are deeply integrated through the vagus nerve and the neuroendocrine system. The vagus nerve is a treelike bundle of fibers extending from the lower part of the brain to nearly every body organ, but particularly the heart, lungs and digestive tract. The neuroendocrine system comprises specialized cells inhabiting nearly all the organs of the body that respond to signals from the brain […]

(Beyond Pesticides, June 16, 2023) Juneteenth is a celebration of freedom for the last 250,000 enslaved people in Galveston, Texas, but it is also a reminder that justice has not historically been “swift” or complete for Black Americans. The holiday commemorates the abolition of slavery in Texas on June 19, 1865, two and a half years after the Emancipation Proclamation.  According to a 2022 Gallup Poll, 40 percent of Americans know “a little bit” or “nothing at all” about Juneteenth. While this is a significant improvement in comparison to the 60 percent for the aforementioned metric in the previous year (when the holiday was federally recognized), greater public awareness is needed. This holiday is a time for individuals and organizations to acknowledge and reflect on their past and current actions or inactions that perpetuate systemic racism. As known from the history books, the Emancipation Proclamation was signed on January 1, 1863, and the civil war ended on April 9, 1865. Juneteenth is a lesser-known anniversary commemorating the emancipation of enslaved people who received news of their freedom two and a half years after Abraham Lincoln’s freedom proclamation. While the technologies in the 19th century had a much slower travel time, […]

(Beyond Pesticides, June 14, 2023) A study published in Scientific Reports finds a link between pesticide exposure and recurrent pregnancy loss (RPL) through oxidative stress and apoptosis (cell death) in the placenta. Recurrent pregnancy loss (RPL) is the loss of three or more successive pregnancies before 24 weeks of gestation (pregnancy) and signifies an underlying reproductive health issue. The study highlights that pesticides’ endocrine-disrupting (ED) properties can have varying adverse impacts on biological processes, including immunology, metabolism, and reproduction. Pregnant women experience frequent exposure to environmental pollutants that pose serious health risks to both mother and newborn. Many known pollutants (e.g., heavy metals, polychlorinated biphenyl, and pesticides) are chemicals with ED properties that can move from the mother to the developing fetus at higher exposure rates. Additionally, pregnant women are experiencing exposure to an increasing number of dangerous industrial chemicals. With a range of scientific data highlighting chemical exposures during pregnancy as a critical window of vulnerability, public awareness of these threats is growing. The study notes, “They are associated with an increasing placental OS [oxidative stress] and placental apoptosis. Specific measures should be taken to decrease maternal exposure to these pollutants’ sources, especially in underdeveloped and developing countries.” For RPL, the research investigated pesticide components in blood plasma, […]

(Beyond Pesticides, June 13, 2023) The specific compounds that comprise one’s scent influence how attractive one is to mosquitoes finds research published in the journal Current Biology by scientists at Johns Hopkins University. Although the findings focus solely on a species of malaria mosquito primarily distributed throughout Sub-Saharan Africa, the results could provide insight into broader concerns over mosquito disease transmission and public health. As it currently stands, personal protective measures and the use of least-toxic repellents are the best methods to address most mosquito problems in the United States. Scientists utilized a mixture and semi-field trials to understand first how mosquitoes became attracted to human hosts. For the field trial, a large facility the size of a college lecture hall was utilized to mimic the sort of open space mosquitoes have available to them in the wild. Eight landing boards were placed in a ring and either heated to human temperature, “baited” with carbon dioxide, or both. Researchers then released 200 mated female mosquitoes that had been starved of food. Scientists tracked the mosquitoes through infrared cameras to determine their trajectory. Only when both heat and carbon dioxide were present did scientists witness high levels of landings on the […]

(Beyond Pesticides, June 9, 2023) Glyphosate, usually marketed as the herbicide Roundup, has long been the poster child for shoddy regulation by both the U.S. Environmental Protection Agency (EPA) and the European Food Safety Authority (EFSA). In a study published June 1, 2023 in Environmental Health by Axel Mie and Christina Rudén, PhD, of Stockholm University and the Centre for Organic Food and Farming in Uppsala, the authors followed up on earlier work that documented deficiencies in information provided to European Union (EU) regulators by manufacturers. They identified nine studies on developmental neurotoxicity (DNT) that had been submitted to the U.S. Environmental Protection Agency (EPA) but were not disclosed to EU authorities. According to the research, seven of these studies would have “actual or potential regulatory impact.” According to the authors: “Of the nine undisclosed DNT studies, three were sponsored by Bayer and performed in their own laboratory. Three studies were sponsored by Syngenta and performed in their Central Toxicology Laboratory. One study each was sponsored by Nissan Chemicals and Ishihara Sangyo Kaisha (ISK), and these were performed at Huntingdon Life Sciences. For the remaining study, the sponsor and laboratory are unknown to us.” This study is a new example […]

(Beyond Pesticides, June 8, 2023) A study published in Nature Communications finds that climate-induced thawing of permafrost (a ground that remains completely frozen for two or more years) threatens approximately 4,500 industrial sites in regions of the Arctic. These thousands of industrial sites used to store hazardous substances have an estimated 13,000 to 20,000 contaminated locations. Not only do these regions pose a grave ecological risk to the Arctic, but they threaten the entire globe. Many studies warn that thawing permafrost in the Arctic region can prompt the reemergence of greenhouse gases (e.g., methane and carbon dioxide), microbes, and hazardous chemicals (e.g., banned pesticides like DDT, heavy metals, etc.). Gases, microbes, and chemicals can drift near the poles, becoming entrapped in ice under the accumulating snowfall. As the global climate continues to rise and the climate crisis worsens, studies like this heed warning of potential adverse effects as ice encapsulating these toxic chemicals melt. Upon melting, some chemicals can volatilize back into the atmosphere, releasing toxicants into the air and aquatic systems, with the ensuing consequences. Microbes frozen for thousands to millions of years can also emerge from thawing permafrost, with unknown implications on human, animal, and ecosystem health. The melting permafrost is already […]

(Beyond Pesticides, June 7, 2023) A systematic review of scientific literature published in Environmental Research on the development of mood disorders among pesticide applicators (farmers, landscapers, etc.) finds an increased risk of depression symptoms over the last decade. The evidence in the review highlights the presence of pesticide-specific biomarkers and biomarkers of depression that determine the positive association between pesticide exposure and the development of depressive symptoms. With more high-quality longitudinal studies to control sociocultural variables, researchers can directly pinpoint risks of developing depression, especially among agricultural workers and landscapers who use pesticides. Research on pesticide-induced diseases commonly investigates pesticide exposure concerning the development of various physical illnesses. However, previous studies show that occupational (work-related) risks of developing depression are high in agriculture, where pesticide use is rampant. Acute exposure to chemicals, including organophosphate, organochlorine, triazine, and carbamate pesticides, tends to put farmers at greater risk of suicide than the general population. There is a lack of information connecting pesticide exposure to the subsequent psychological (psychiatric) effects on the general population. Additionally, household pesticide exposure varies from occupational exposure via exposure frequency, duration, intensity, and type.   According to the World Health Organization (WHO), depression affects 322 million people globally, with the number of diagnosed patients increasing by 18.4% from 2005 to […]

(Beyond Pesticides, June 6, 2023) Government agencies in Hawaii are making preparations to release a small parasitoid in an attempt to control infestations of coffee berry borer (CBB) in the state, according to a release published by the University of Hawaii.  “This biological control agent has the potential to make significant positive economic impacts in the Hawaiʻi coffee industry, and offers an environmentally safe way to manage CBB,” says Mark Wright, PhD, professor at UH. “The Hawaiʻi coffee industry is economically and culturally significant, and we hope that this work will improve the lives of many people associated with the industry.” The planned release comes at a time of increasing interest in nontoxic biological pest management as a means of reducing the harmful effects of industrially produced pesticides. As early as fall 2023, the U.S. Department of Agriculture’s Agriculture Research Service (USDA ARS) and UH’s Department of Plant and Environmental Protection Services plan to release thousands of parasitic wasps throughout coffee growing areas in Maui, O’ahu and the Big Island. The parasitoid in question is Phymastichus coffea, a wasp that lays its eggs in the abdomen of coffee berry borers. According to researchers, the wasp becomes attracted to the coffee […]

(Beyond Pesticides, June 5, 2023) Butterflies—the most attractive of our insect fauna—are disappearing at an appalling rate, largely due to pesticide use. Recent studies have documented declines of almost 50% from 1990 to 2011 in Europe (with trends continuing), of 58 percent between 2000 and 2009 in the U.K., and of 33% from 1996–2016 in the state of Ohio in the U.S. Even steeper declines have been documented for Monarch butterflies, with an 80 percent decline of Eastern monarchs and 99 percent decline of Western monarchs. Tell EPA to eliminate pesticides that threaten butterflies. Tell the U.S. Fish and Wildlife Service and Department of Interior to help bring back butterflies by eliminating the use of pesticides that threaten them. Tell Congress that EPA and other agencies need to do their job and protect our most charismatic insects. Last year, EPA admitted that three neonicotinoid pesticides are “likely to adversely affect from two-thirds to over three-fourths of America’s endangered species—1,225 to 1,445 species in all,” including many butterfly species. On May 5 of this year, EPA released new analyses of these neonics’ effects on endangered species. EPA’s analyses focus on the species most at risk of extinction, and the results represent […]

(Beyond Pesticides, June 2, 2023) Scientists have identified 97 different types of pesticides and flame retardants in primate fecal samples, recently reporting their results in the journal Biology Letters. In Uganda’s Kibale National Park, researchers studied the chemical exposure of four species of primates (chimpanzees, Ugandan red colobus, olive baboons and red-tailed monkeys), adding to previous research on the subject. The chemicals demonstrate a measurable effect on primate growth and development, sparking considerable unease as to the future health of these critical species. This study shows how even within a protected national park, wildlife species are at risk from chemical pollution. According to advocates, the use of dangerous pesticides and flame retardants, therefore, must be entirely stopped in order to protect the future viability of wildlife species.  Scientists collected a total of 71 fecal samples from the four chosen species to measure levels of chemicals and hormones in a noninvasive manner. After sample analysis, researchers highlight three main groups of chemical pollutants: organochlorine pesticides (OCPs), brominated flame retardants (BFRs), and organophosphate esters (OPEs). Although in a protected area, wildlife species encounter humans through tourism, research, and human development surrounding the park. As these pesticides are so prevalent in areas of […]

Eco-Friendly Parks for All (EFPA)*, a coalition of environmental, public health and political action organizations, has teamed up with Beyond Pesticides, New York City Parks and Recreation Department, and Stonyfield Organic Yogurt to celebrate the success of pilot organic land management programs at eight sites across the five boroughs. 

(Beyond Pesticides, May 30, 2023) On Endangered Species Day, May 19, the U.S. Environmental Protection Agency (EPA) revealed an unfortunate degree of hypocrisy in its claims to protect endangered species from pesticides. Tell EPA and Congress that dwindling biodiversity is an existential crisis that requires removing serious threats posed by pesticides. EPA announced that it “is publishing a group of StoryMaps to raise public awareness about protecting endangered species from pesticides.” It continues, “Through its Vulnerable Species Pilot, EPA has been identifying endangered species that are vulnerable to pesticides, developing mitigations to protect them from pesticide exposure, and will apply the mitigations to many types of pesticides.” However, pesticide use is a major cause of declining biodiversity, which is manifested in extinctions, endangered species, and species vulnerable to environmental disturbances—including climate change, habitat fragmentation, and toxic chemicals. If EPA is serious about protecting biodiversity, it must look first at the ways it has created the crisis in the first place. Studies upon studies upon studies show that pesticides are a major contributor to the loss of insect biomass and diversity known as the “insect apocalypse,” particularly in combination with climate change. Insects are important as pollinators and as part of […]

(Beyond Pesticides, May 26, 2023)The use of pesticides in agriculture, transportation, and domestic settings has created a disastrous conflict for the human species. Two irreconcilable facts confront humans as they try to adapt to the consequences of earlier choices: One, industrial civilization came to believe that because some insects, fungi, and other organisms like to eat the same plants humans eat, humans can kill them with impunity; two, because some insects and other organisms are necessary to the health and reproduction of plants, humans need to protect them. At no point in history have people acknowledged that it is very difficult to kill the “bad” actors while protecting the “good” ones. There are not really two sides to the biological fact; rather, pesticides and biodiversity meet each other on a single plane, like a Möbius strip. Among the most dire effects of pesticides are their ruination of pollinators. Bees spring to mind as our primary pollinators, but they are by no means the only ones. Butterflies, often regarded as mere ornamental additions to a landscape, are actually significant pollinators themselves. Monarchs pollinate many flowers, including calendula and yarrow. Other butterflies pollinate dill, celery, fennel, cilantro, lettuce, peas, and basil, among […]

(Beyond Pesticides, May 25, 2023) A review of scientific literature published in the Journal of Endocrinological Investigation demonstrates exposure to past and current-use endocrine-disrupting chemicals (EDCs), like pesticides, have a long history of severe adverse human health effects. Endocrine disruptors are xenobiotics (i.e., chemical substances like toxic pesticides foreign to an organism or ecosystem) present in nearly all organisms and ecosystems. The World Health Organization (WHO), European Union (EU), and endocrine disruptor expert (deceased) Theo Colborn, Ph.D., classify over 55 to 177 chemical compounds as endocrine disruptors, including various household products like detergents, disinfectants, plastics, and pesticides. Endocrine disruption can lead to several health problems, including hormone-related cancer development (e.g., thyroid, breast, ovarian, prostate, testicular), reproductive dysfunction, and diabetes/obesity that can span generations. Therefore, studies related to pesticides and endocrine disruption help scientists understand the underlying mechanisms that indirectly or directly cause infertility, among other health issues. The review notes, “New evidence supports the role of other EDCs as possibly carcinogenic and pregnant women should avoid risk area and exposure. The relationship between EDCs and cancer supports the need for effective prevention policies increasing public awareness.” The review examines the relationship between EDCs and various hormone-mediated various (i.e., breast, prostate, testicle, ovary, and thyroid) to determine the carcinogenicity of the chemicals and their impact on public […]

(Beyond Pesticides, May 23 2023) New research is zeroing in on the role of 10 commonly used pesticides in the development of Parkinson’s. Published in the journal Nature Communications by a team of scientists lead by researchers at the University of California, Los Angeles, the study focused on the toxicity of these pesticides to neurons that have been found to lead to the presentation of the disease. Research is increasingly focusing on environmental exposures, and pesticides in particular, as a major factor in the development of Parkinson’s. This study adds further evidence that this line of research is a valid and worthwhile undertaking for the nearly one million people in the United States struggling with this incurable disease. [The authors note that the herbicide paraquat’s strong connection to Parkinson’s is not addressed in this study, but is the focus of a separate manuscript.] Scientists sought to further focus on which pesticides were most likely to be playing a role in Parkinson’s development. Records from California’s vast pesticide use database aided the search. From a comprehensive pesticide-wide association study, 53 of 288 pesticides screened were found to be linked to Parkinson’s. Scientists then took these 53 pesticides and conducted live-cell imaging […]

(Beyond Pesticides, May 19, 2023) Agricultural intensification is the leading factor driving declines in bird populations across Europe, according to research published in the Proceedings of the National Academy of Sciences (PNAS) this week. Among all potential anthropogenic impacts, agricultural intensification, in particular pesticide and fertilizer use, was found to be more dramatic than forest alterations, urbanization, and climate change. “I don’t think a study has looked at all these factors in one go, in such a sophisticated fashion, correcting for one variable alongside another; and it comes out with a very clear message,” lead author Richard Gregory, PhD, of UK nonprofit The Royal Society for the Protection of Birds, told The Guardian. Researchers utilized data dating back to the early-1980s, including annual bird surveys and national and supranational analyses, as well as information on land use cover, farm inputs, and temperature changes within the time frame. Bird habitat and ecological traits were also considered in the context of declines, and a statistical analysis aided researchers in capturing trends over time. Results confirmed that birds are overall experiencing significant declines in Europe, with data recording 25% losses in bird abundance since 1980. However, certain groups of birds are faring worse […]

(Beyond Pesticides, May 18, 2023) A study published in Food and Chemical Toxicology finds pesticide residues in beehive products pose a safety risk from dietary consumption. Beehive products (i.e., bee bread, propolis, beeswax, and royal jelly) from beekeeping or apiculture are said to have nutraceutical (health and medicinal benefits) properties. However, a wide range of pesticide residues (i.e., tau-fluvalinate, coumaphos, chlorfenvinphos, chlorpyrifos, and amitraz), especially acaricides for killing ticks and mites in hives, may accumulate in beehive products up to concentrations that pose a potential health risk. Environmental contaminants like pesticides are ubiquitous in the environment, with 90 percent of Americans having at least one pesticide compound in their body. Many of these chemical compounds remain in soils, water (solid and liquid), and the surrounding air at levels exceeding U.S. Environmental Protection Agency (EPA) standards. Therefore, individuals still encounter pesticide compounds at varying concentrations, adding to the toxic body burden of those harmful chemicals currently in use. The research methodology includes a review of the scientific literature on pesticide contamination in hive products and a dietary risk assessment. The risk assessment calculation uses scientific studies to determine the recommended daily intake values and concentration data. Researchers compare exposure values in products to health-based guidance, determining the potential acute and […]

(Beyond Pesticides, May 15, 2023) Say “legacy contaminant” or “forever chemical” and most people today think “PFAS” (perfluoroalkyl substances), but PFAS are just the latest persistent toxic chemicals recognized as presenting an alarmingly difficult cleanup problem. Fortunately, steps are being taken by governments and businesses to eliminate use of PFAS. (Organic farmers concerned about the integrity of their products have been leaders in these efforts.) Although government officials often devote considerable energy and resources to cleaning up contamination, the continued manufacturing of these chemicals and their release into the environment creates a futile situation. The U.S. is a signatory to the 2001 Stockholm Convention, which provides an international framework for moving persistent organic pollutants out of commerce, but the U.S. Senate never ratified it.     Ask your Senators to ratify the Stockholm convention. Tell EPA that persistent toxic pesticides must be considered to pose an “unreasonable risk to the environment under the Federal Insecticide, Fungicide, and Rodenticide Act (FIFRA),” which must result in cancellation of their registrations.  PFAS contamination is just the latest chapter of a very old story. Legacy contamination of our bodies and the environment is partly a result of a slow piecemeal approach to eliminating these toxic chemicals. […]

(Beyond Pesticides, May 11, 2023) A study published in NeuroToxicology finds occupational (work-related), chronic exposure to pesticides increases risk factors of epilepsy, a neurological disorder causing unprovoked, reoccurring seizures. Mounting evidence over the past years shows that chronic exposure to sublethal (low) levels of pesticides can cause neurotoxic effects or exacerbate preexisting chemical damage to the nervous system. Although the mechanism by which pesticides induce disease development remains unclear, this study suggests environmental pesticide exposure increases seizure risk through mechanisms at molecular or subcellular levels. Approximately 3.4 million individuals in the U.S. live with epilepsy, and mortality from this disorder is rising nationwide. Over 300 environmental contaminants and their byproducts, including pesticides, are chemicals commonly present in human blood and urine samples and can increase neurotoxicity risk when crossing the brain barrier. Considering half of all epilepsy etiologies (causes) are of idiopathic (unknown) origins, studies like this highlight the importance of understanding how consistent chemical exposure can impact long-term health and disease prognosis. The study notes, “[The] approach to a real-world exposure scenario to pesticides in a large agriculture area over 17 years; […] can be linked to the novel approaches proposed for simulating real-life exposures, thus contributing to a better understanding of the real-life risk associated with long-term […]

(Beyond Pesticides, May 10, 2023) Scientists are uncovering more information about a fungal pathogen behind a disease outbreak in Indian hospitals that sickened 10 pre-term infants. According to a study published in mBIO late last month, the yeast pathogen Lodderomyces elongisporus was the causative agent of this outbreak and is rapidly evolving resistance to control measures. There is growing concern globally over the spread of fungal pathogens, with scientists increasingly identifying agriculture as the driver behind pathogenic mutations and resistance. Scientists in Delhi, India were called to investigate an outbreak of L. elongisporus that sickened ten infants with low birthweight in the neonatal intensive care unit (NICU) from September 2021 to February 2022. L. elongisporus is more commonly known for attacking severely immunocompromised adults, including those with heart conditions or a history of intravenous drug use. However, there are an increasing number of reports of fungal infections in neonatal care units. Further, the fungus appears to be spreading globally, with reports of infections in the Middle East, Europe, Australia, and North America. “This yeast is among a growing list of fungi capable of causing severe infections among humans,” said lead study author Jianping Xu, PhD a professor at McMaster University […]

(Beyond Pesticides, May 9, 2022) The Colorado legislature last week passed SB23-266, a bill limiting the use of bee-toxic neonicotinoid pesticides in the state. The news comes as other states consider their own restrictions, and the U.S. Environmental Protection Agency (EPA) is publishing details on exactly which endangered species are set to be harmed by the ongoing use of these harmful insecticides. This latest news shows that protecting pollinators is possible, and urgently needed given growing understanding of the dangers these chemicals pose to the most vulnerable wildlife in the country.   The Colorado bill requires the state’s commissioner of agriculture to adopt rules designating neonicotinoid pesticides as ‘limited-use’ pesticides in the state. With this designation, only licensed pesticide dealers may sell products containing these chemicals. Per the state’s legal code, the “limited-use” designation means the same as a federal “restricted-use” pesticide, which permits sales and use only for certified applicators. Passage of this bill marks an important step forward for pollinator protection efforts in the state. It will help ensure that homeowners are not able to easily purchase this product at big box retailers, but will allow continued use in residential areas and in agriculture. Colorado’s bill fulfills guidance […]

(Beyond Pesticides, May 5, 2023) Low level exposure to pyrethroid insecticides found in common pesticide brands like RAID and ORTHO result in neurodevelopmental damage to laboratory animals, reinforcing evidence of harm found in epidemiological studies on human exposure to these chemicals. According to research published in PNAS Nexus, mice exposed to the pyrethroid deltamethrin displayed atypical behavior similar to humans with developmental disorders. “We are not saying these mice have autism or that they have ADHD. That’s not the goal here,” said James Burkett, PhD, study coauthor and assistant professor of neuroscience in the UToledo College of Medicine. “What we are saying is that something in their brain has been altered by this exposure and it’s resulting in the same kinds of behaviors that we see in children with autism.” Scientists arrived at this determination by exposing a group of mouse mothers to consistent low levels of deltamethrin in their food during preconception, pregnancy, and lactation. The study notes that the amount of pesticide provided was “well below the benchmark dose for regulatory guidance.” A separate control group was given no pesticide in its food. Offspring from the female mice were then put through behavioral tests on social behavior, restrictive […]

(Beyond Pesticides, May 4, 2023) One of the most widely used insecticides in California, Intrepid 2F, contains harmful levels of per- and polyfluoroalkyl substances (PFAS), or “forever chemicals,” according to a report by the Center for Biological Diversity (CBD) and Public Employees for Environmental Responsibility (PEER). In fact, 40 percent of pesticide products in the report tested positive for high levels of PFAS. PFAS are common in non-stick cookware, cleaning/personal care products, food packaging, and other consumer products. However, these compounds are also in pesticide products. Despite evidence on the dangers of PFAS stretching as far back as the 1950s, federal agencies sat by the sidelines as the plastics industry continued adding the material to new products. From widespread presence in farm fields and sewage sludge to contaminated water bodies throughout the U.S., PFAS has made its way into the environment and our bodies. PFAS are even present in remote environments like the Arctic, Antarctica, and Eastern European Tibetan Plateau. A study published in 2020 identified PFAS as common products to which Americans are exposed daily. The U.S. Centers for Disease Control and Prevention (CDC) determined that 98% of Americans have some level of PFAS in their bloodstream, with studies reporting PFAS compounds are detectable in infants, children, and pregnant women. With […]