(Beyond Pesticides, December 12, 2025) A study concluding that the weed killer glyphosate did not cause cancer was retracted last week after it was revealed in lawsuit documents that the authors did not disclose their relationship with Monsanto/Bayer. The editor-and-chief, Martin van den Berg, PhD of Regulatory Toxicology and Pharmacology, which published the article 25 years ago, wrote in the journal, “Concerns were raised regarding the authorship of this paper, validity of the research findings in the context of misrepresentation of the contributions by the authors and the study sponsor and potential conflicts of interest of the authors.”  The study, titled “Safety Evaluation and Risk Assessment of the Herbicide Roundup and Its Active Ingredient, Glyphosate, for Humans” and coauthored by three researchers in New York, The Netherlands, and Canada, was referred to as a “Landmark glyphosate safety study” in a recent article by U.S. Right to Know.   While this retraction not only sheds light on Monsanto’s influence through ghostwriting, it adds to the wide body of evidence regarding the regulatory deficiencies currently in place. The revelation is a reminder of related incidents in which Monsanto (Bayer) and other companies have wielded excessive influence at the U.S. Environmental Protection Agency (EPA), undermining the integrity of the science needed to inform the regulatory decisions that safeguard health and the environment. (See Daily News Corruption Problems Persist at EPA.)  EPA Deficiencies  In addition to the initial registration process, the Federal Insecticide, Fungicide, and Rodenticide Act (FIFRA) requires that EPA conduct a registration review of all pesticide […]

(Beyond Pesticides, December 10, 2025) On November 21, 2025, the International Agency for Research on Cancer (IARC), a branch of the World Health Organization (WHO), designated the endocrine-disrupting herbicide atrazine (as well as the herbicide alachlor) as “probably carcinogenic to humans.” Manufactured by the multinational, China-based pesticide corporation Syngenta, atrazine has been linked to various adverse health effects and runoff into waterways across the continental United States for years. Tyrone Hayes, PhD, researcher and professor of Integrative Biology at the University of California, Berkeley, who studies the endocrine-disrupting properties of atrazine and other chemicals, has said that atrazine induces cancer by turning on the enzyme aromatase. Dr. Hayes told conferees of Beyond Pesticides’ 31st National Pesticide Forum that: “[W]hat is concerning about aromatase expression and estrogen in mammals is breast cancer and prostate cancer. With regard to prostate cancer, there is an 8.4-fold increase in prostate cancer in men who work in atrazine factories and bag atrazine. There is at least one correlational study, which I didn’t publish, that shows women whose well water is contaminated with atrazine are more likely to develop breast cancer than women who live in the same community, but don’t drink the well water. (Kettles, […]

(Beyond Pesticides, December 9, 2025) In the Journal of Environmental Quality, researchers at the U.S. Department of Agriculture (USDA) report that a 4-year organically managed corn-soybean-oat system reduces nitrogen (N) loads by 50 percent with corn and soybean yields “equivalent to or higher than conventional [chemical-intensive] in most years.” The findings from a 7-year study comparing nitrate loss in organic and chemical-intensive management found that organically managed perennial pasture reduced nitrogen loads significantly. The study, which focused on nitrate pollution in agriculture that harms biodiversity, threatens waterways, drinking water, and public health, and releases nitrous oxide (an extremely potent greenhouse gas), was conducted at USDA’s National Laboratory for Agriculture and the Environment. Organic and regenerative organic farmers and businesses posit that if commodity crops can be grown in organically managed systems with competitive yields, then this supports their argument for alternative systems not only feasible but economically sustainable and responsible. Background and Methodology The researchers note that, in the eastern and U.S. Midwest, “subsurface tile drainage” (the practice of manually draining fields below the surface soil to assist fields that are otherwise challenging to drain due to wet areas/highly compacted soils) has exacerbated nitrogen and nutrient runoff, ultimately leading to diminished soil health. […]

(Beyond Pesticides, December 5, 2025) A study published this month in Environmental Pollution analyzes the role of neonicotinoid insecticide exposure on bird populations, finding a significant negative effect of imidacloprid use on insectivorous bird abundance. In comparing the effects of the insecticide imidacloprid on bird abundance in France before and after the 2018 ban, the researchers show a weak recovery of bird populations after 2018. The persistent nature of imidacloprid, however, as well as the continued use of other petrochemical pesticides that have adverse effects on bird species, continues to impact populations of all types of birds and other wildlife, leading to cascading impacts on biodiversity.    “Our study shows that imidacloprid is a major covariate of the abundance of birds, in addition to other pesticides that are also negatively related to bird populations, and that these effects are not uniform across species,” the authors report. They continue in saying that the relationship between neonicotinoids and bird abundance varied across bird diets, as “the abundance of insectivorous birds was consistently lower under increasing pesticide use, in particular imidacloprid.” Background As shared in the study and on Beyond Pesticides’ Birds page, bird species can be exposed to pesticides directly through ingestion […]

(Beyond Pesticides, December 2, 2025) A personal and heartfelt message from Jay Feldman, executive director, for the holiday season! During this holiday season, I’m writing on behalf of Beyond Pesticides’ staff and board of directors to wish you a Happy Holiday. We celebrate with you our shared commitment to the values and principles that protect the well-being of people and the ecosystems on which life depends. In reflecting on the steps we are taking at Beyond Pesticides to confront existential health and environmental threats, I believe we, together, are pursuing a meaningful path forward—and I am thankful for that.  If you can, and in honor of Giving Tuesday, please consider a gift sometime during this holiday season on our secure website at bp-dc.org/give2025. Your support of any size makes a tremendous difference! Thank you! Before the specifics, I think it is important to say that with the current challenges being endured by the people of our country and around the world, threats to a sustainable future can be overshadowed by the crises that impede daily survival. At Beyond Pesticides, I am thankful we recognize the immediate support needed in this regard, at the same time that we move ahead with the urgent […]

(Beyond Pesticides, November 20, 2025) Recent scientific literature finds heightened toxicity associated with pesticide metabolites, the transformation/breakdown products of the parent compounds, that threaten the health of the soil, wildlife, and humans. This research stresses the importance of the U.S. Environmental Protection Agency (EPA) evaluating metabolites, which is currently insufficiently included in regulatory processes. In a literature review in Global Change Biology, the researchers point out multiple areas in which regulations fail to address key criteria, including metabolites, saying: “Pesticide risk assessments currently rely on surrogate species and focus primarily on acute lethality metrics, failing to capture the broader impacts on non-target organisms and thus biodiversity. Under the directives of regulatory agencies worldwide, this traditional approach overlooks the complex interactions between multiple stressors, including climate change, land-use shifts, and pesticide transformation products. Pesticide risk assessments must therefore undergo a paradigm shift to account for these complex interactions, which disproportionately affect insect pollinators, other non-target species, and biodiversity at large.” A metabolite is a breakdown product that forms when a pesticide is used in the environment and mixes with air, water, soil, or living organisms. All metabolites fall under the category of transformation products, which is the broader term for any […]

(Beyond Pesticides, November 19, 2025) In the book, Biological Control Systems and Climate Change, published this month, Danilo Russo, PhD—a speaker during the first session of our 42nd National Forum, The Pesticide Threat to Environmental Health: Advancing Holistic Solutions Aligned with Nature—and other researchers add to the existing literature on the climate change threat to ecosystem services. Dr. Russo’s chapter, entitled “Impact of Climate Change on Bats Involved in Biological Control,” explains one of the lost benefits of ecological balance attributable to the climate crisis. As explained in the book: “In conservation biological control, habitats surrounding and within crops are managed to favour an increase in natural enemy populations while suppressing pest populations. These agroecological systems can be complex, and are affected by climate change.” The ability of climate change to influence the effectiveness of biological control systems is explored, showing the “effects on the large diversity of macro- and microorganisms involved in biocontrol, and the possible increase or decrease in pest outbreaks following changes in characteristics (morphology, physiology, behaviour….), distribution or phenology.” Dr. Russo is a full professor of ecology at the University of Naples Federico II, an international leader in bat research, and coauthor of A Natural History […]

(Beyond Pesticides, November 18, 2025) A study published in Horticultural Plant Journal provides additional evidence on the viability of organically managed farmland based on tomatoes cultivated through traditional plant breeding and regional variances. The authors of the research find that, “Despite the positive trend of the organic sector’s development in Europe, the number of tomato varieties bred for organic farming is still limited since efforts have been mainly focused on high input conditions.” They continue: “As a result, the existing cultivars may not suit to organic production [ ] as cultivars chosen for conventional [chemical-intensive] systems often respond well to chemical fertilizers to improve crop output, but they might not maximize nutrient uptake in organic systems where minor external inputs are provided.” In this context, the marketplace is not maximizing the potential productivity of organic systems due to the limited availability of seeds and plant material best suited to conditions in sync with local ecosystems. The designed methodology, as well as the findings, show that there are opportunities for public investment to support systems that cultivate agricultural products without reliance on petrochemical-based fertilizers, pesticides, and seeds treated with pesticide products and other genetically modified characteristics. For millennia, humans have worked […]

(Beyond Pesticides, November 10, 2025) With a small but growing organic beer market, Beyond Pesticides is urging breweries to align with ecological farming practices and to seek out organic sources for their ingredients. In a June 2025 release, the marketing research firm Data Bridge reports that, “The global organic beer market size was valued at USD 7.24 billion in 2024 and is expected to reach USD 11.90 billion by 2032, at a CAGR [Compound Annual Growth Rate] of 6.4% during the forecast period.” The company attributes the growth to “health-conscious and environmentally-aware consumers” and finds “rising consumer preference for organic and clean-label beverages,” with consumers “actively seeking beer options made with organic hops, malt, and natural ingredients, free from synthetic pesticides or GMOs  [genetically modified organisms].” Harmful pesticides, including glyphosate, 2,4-D, and other toxic herbicides, insecticides, and fungicides, are used in the production of the ingredients of beer. Residues may remain in barley, oats, wheat, and hops used to make beer. Not only do the residues pose a risk to beer drinkers, but growing these crops nonorganically threatens farmworkers, waterways, wildlife, and pollinators.   More than 800 million pounds of pesticides are used each year in U.S. agriculture, with devastating impacts on soil life, pollinators, and ecosystem health. Harm to the soil microbiome and invertebrates like worms and beetles is magnified by synergistic interactions with chemical fertilizers, undermining the foundation of […]

(Beyond Pesticides, November 5, 2025) Environmental and public health advocates, farmers, and business leaders are raising a glass to the expansion of organic hop production, which aims to boost the viability and growth of organic-certified beer products in the UK. A 2024 report by UK-based Organic Research Centre, in partnership with farmers, follows three years of field trials to assess the suitability of various hop varieties in organically managed systems. At a time when organic hops production in the UK has dropped significantly due to varieties that are vulnerable to downy mildew and hop powdery mildew, the report offers a blueprint for additional on-farm, applied research in the United States, including from groups such as the Organic Farming Research Foundation’s (OFRF) Farmer-Led Trials Program. The report cites promising results for new hop varieties. The continuous use of pesticides not only contributes to biodiversity collapse, public health deterioration, and the climate crisis, but also to the ability to enjoy a beer without fear of exposure to toxic chemicals, including evidence of glyphosate residues found in popular beer and wine brands. (See Daily News here and here.) Background and Methodology The authors of this report reflect on their years-long field trials and […]

(Beyond Pesticides, November 4, 2025) A study of earthworms published in Environmental Science & Technology highlights how chemical mixtures can have both synergistic and species-specific effects, threatening the soil microbiome and overall soil health. In exposing two species, Eisenia fetida and Metaphire guillelmi, to the weed killer glyphosate alone and in combination with urea, a form of synthetic nitrogen fertilizer, the researchers find enhanced toxicity with co-exposure as well as varying health effects between the two species. These results emphasize the need to test a wide variety of nontarget organisms for impacts from environmental contaminants, since species, even within the same genus or family, can exhibit vastly different effects. Glyphosate, as one of the most widely used herbicides worldwide, is highly researched, with a multitude of studies linking the weed killer to effects on humans, wildlife, and soil ecosystems. Since simultaneous application of glyphosate and urea frequently occurs in agriculture, the effects of this mixture on earthworms are crucial for understanding the overall impacts on soil health. In exposing the two species to the individual compounds and as a mixture, the authors report increased glyphosate residues in earthworm gut contents, reduced body weight, aggravated intestinal tissue damage, sharply decreased digestive […]

(Beyond Pesticides, October 29, 2025) The latest research on bats and beavers, ecosystem services, and biodiversity adds to a wide body of science on the importance of a balanced ecosystem. In both the Bulletin of the National Research Centre and Journal of Animal Ecology, the researchers highlight the interconnectedness not only between wildlife species but to broader ecosystem functioning and human health implications. Researchers in the Journal article add to the growing body of science connecting an abundance of bat species in areas with established beaver dams, highlighting how interconnected wildlife is. The reporting on this recent research coincides with Beyond Pesticides’ 42nd National Forum, The Pesticide Threat to Environmental Health: Advancing Holistic Solutions Aligned with Nature, scheduled for today, October 29. As the author of the article in the Bulletin of the National Research Centre, entitled “The complex web between environmental disruption, pesticide use, and human health: lessons from the bat crisis,” states: “The close relationship between environmental balance, biodiversity, and human health has long been a concern of science and public policy. Disruptions in ecosystems often trigger cascading effects that extend far beyond the original ecological imbalance, affecting agricultural practices, food security, and public health.” Bat Declines and […]

(Beyond Pesticides, October 28, 2025) A California-based population study published in BMC Public Health finds that “7.5 [percent] of all pregnant people in California who gave birth in 2021 lived within 1 km [kilometer] of agricultural fields where OP pesticides [organophosphates] had been used during their pregnancy. . .” Despite a 54 percent decrease in overall use of the neurotoxic insecticide chlorpyrifos in the state between 2016 and 2021, after a statewide ban on the organophosphate insecticide in 2016, researchers found that in one California county, “more than 50 [percent] of pregnant people lived within 1 km of OP pesticide use.” Significant disparities were found in terms of elevated exposure to pesticides, “with Hispanic/Latine, young people, and residents of the predominantly fruit and vegetable growing Central Coast region being most likely to live near OP pesticide applications during pregnancy.” The authors suggest that “regulatory changes to limit use or restrict applications in close proximity to residential areas could have a substantial public health benefit on children’s brain development.” These findings add to the existing scientific literature on perinatal and maternal pesticide exposure associated with adverse long-term health effects for children and mothers. They also serve as a reminder to public […]

(Beyond Pesticides, October 27, 2025) With the confluence of science and law, the spotlight is on sewage sludge fertilizer and its contaminants, including per- and polyfluoroalkyl substances (PFAS). Sewage sludge (biosolids) is a byproduct of sewage treatment and is used as a source of organic matter for amending soil in nonorganic agriculture and landscaping. In light of a recent settlement in a lawsuit filed by Beyond Pesticides against ScottsMiracle-Gro, ongoing litigation against GreenTechnologies, LLC, and a major study identifying 414 contaminants of emerging concern (CECs), Beyond Pesticides’ network is calling on Governors and local officials to ban the use of biosolids on farms and parks, until there is adequate testing of toxic residues—which does not currently exist.   The lawsuits against producers of sewage sludge fertilizer cite test results showing PFAS residues in the companies’ products and numerous scientific studies on the adverse effects of PFAS to public health, wildlife, and pollinators. (See settlement statement recently reached with ScottsMiracle-Gro.)  A literature review published in Frontiers in Environmental Chemistry identifies CECs in soils, untreated and treated sewage sludge (biosolids), and dust, across 151 peer-reviewed studies released between 2018 and 2023—emphasizing the range of potential exposure pathways across various products, including classes of pesticides like neonicotinoid insecticides. […]

(Beyond Pesticides, October 24, 2025) A literature review published in Science of the Total Environment reports numerous peer-reviewed studies associating prenatal and childhood pesticide exposure to measurable alterations to children’s immune systems, including indicators of immunosuppression and increases in pro-inflammatory cytokines, among other adverse health effects. These immune system alterations are linked to higher infection risk and potentially contribute to autoimmune diseases and allergies later in life. For over four decades, Beyond Pesticides has tracked the peer-reviewed science and identified a preponderance of evidence linking pesticide and chemical-dependent pest management to adverse human and ecological health effects. In this spirit, public health and environmental advocates continue to call for a wholesale transition to organic land management and organic pest management as biodiversity, public health, and climate crises continue to mount. This mission supports the growth of the Parks for a Sustainable Future Program, where nineteen cities in eleven states across the country engage in pilot projects to transition parks, playing fields, and schoolyards to organic management practices and protect the health of children. Background and Methodology “This study aimed to evaluate the extent of immunotoxicity and correlation between exposure to pesticides and immune system alterations in children under five years […]

(Beyond Pesticides, October 20, 2025) With the release of a study that links the use of nitrogen fertilizer in combination with antibiotic pesticides to escalating bacterial resistance, public health advocates are renewing their call for the U.S. Environmental Protection Agency (EPA) and the U.S. Congress to eliminate antibiotic pesticide use in land management. This action comes on the heels of a World Health Organization (WHO) study finding that antibiotic resistance is evolving even faster than previously thought. WHO finds, “One in six laboratory-confirmed bacterial infections causing common infections in people worldwide in 2023 were resistant to antibiotic treatments. . .. Between 2018 and 2023, antibiotic resistance rose in over 40% of the pathogen-antibiotic combinations monitored, with an average annual increase of 5–15%.”  These findings, linking pesticides, antibiotics, and nitrogen fertilizers to antibiotic resistance, again raise serious concerns about the deadly impacts of conventional (chemical-intensive) agricultural practices on human health. The researchers found that nitrogen is a strong driver of resistance processes. The richness and diversity of phages—viruses that attack bacteria and can transmit antibiotic resistance genes (ARGs)—is highest in the groups exposed to both nitrogen and combined pesticides, and the abundance of ARGs in phages becomes “markedly elevated” in those same exposure conditions.  Bacterial […]

(Beyond Pesticides, October 17, 2025) Earlier this week, on October 13, the fossil fuel industry, commodity crop groups, and their political allies celebrated Global Fertilizer Day. The industry is celebrating the widespread (and growing) use of petroleum products, including synthetic, nitrogen-based and fossil-fuel derived fertilizers. As a response to industry claims that petrochemical pesticides and fertilizers are critical to ensuring global food security, Beyond Pesticides and a broad coalition spanning civil society, scientists, farmers, farmworkers and working people are pushing back against toxic chemical dependency and advancing organic land (agricultural and nonagricultural) management as cost-effective, productive, and protective of health and the environment.   A review last year in the New England Journal of Medicine (NEJM) highlights the urgent need to address the widespread chemical pollution stemming from the petrochemical industry, underscoring the dire implications for public health. Tracey Woodruff, PhD, author and professor at the University of California San Francisco (UCSF), emphatically states, “We need to recognize the very real harm that petrochemicals are having on people’s health. Many of these fossil-fuel-based chemicals are endocrine disruptors, meaning they interfere with hormonal systems, and they are part of the disturbing rise in disease.” (Watch Dr. Woodruff’s talk to the 41st National Forum, Fossil Fuels […]

(Beyond Pesticides, October 16, 2025) An important new study links pesticides, antibiotics, and nitrogen fertilizers to the extreme global crisis of antibiotic resistance, raising serious concerns about the adverse impacts of conventional (chemical-intensive) agricultural practices. The research team, from several Chinese universities and laboratories and Queen’s University in Belfast, conducted a three-year study in China using soil bacteria and phages (bacteriophages, or viruses that invade bacteria) from an experimental field, exposing them to a variety of conditions ranging from the control (no exposures) to various combinations of nitrogen fertilizer and two categories of pesticides (the insecticide chlorpyrifos and a blend of the fungicides azoxystrobin and propiconazole). Phages are viruses that eat bacteria. They invade the bacterial cell and, in various ways, cause the death of the bacterium. Some viral genes cause the cells to lyse, or dissolve, releasing their genetic material into the surrounding environment, where other organisms can pick up new genes. In this way, phages are a major pipeline for horizontal gene transfer (movement of genes in bacteria from one bacterial species to another) among microbes. This phenomenon is of increasing concern because the genes circulating in this marketplace include many that enhance antibiotic resistance. The researchers were […]

(Beyond Pesticides, October 8, 2025) A study, Pesticides detected in two urban areas have implications for local butterfly conservation, published in partnership with researchers at Xerces Society for Invertebrate Conservation, University of Binghamton (New York), and University of Nevada, reports widespread pesticide residues in the host plants of butterflies located in green spaces in the cities of Sacramento, California, and Albuquerque, New Mexico. Just 22 of the hundreds of collected samples had no detectable residues, with all other samples containing some combination of 47 compounds of the 94 tested pesticides in the plant tissue. Of the 47 compounds, 4 are neonicotinoid insecticides linked to adverse effects for bee and pollinator populations based on previous peer-reviewed research. The fungicide azoxystrobin and the insecticide chlorantraniliprole were detected at lethal/sublethal concentrations, according to the report authors. “Residential landscapes have high conservation potential for butterflies and other invertebrates,” says Aaron Anderson, co-lead author of the report and pesticide program specialist at Xerces Society for Invertebrate Conservation. He continues: “But, these findings show how pervasive pesticide contamination can be in towns and cities, and underscore that protecting wildlife in these areas includes addressing pesticides.” The report’s results underscore the pervasiveness of pesticide drift and dispel the myth […]

(Beyond Pesticides, October 7, 2025) Published in Environment International, a study utilizing silicone wristbands provides a snapshot of chemical exposure in over 600 participants across 10 European countries. Using the wristbands as passive and noninvasive samplers, the researchers find that organic farmers’ wristbands contain lower pesticide levels than other groups, offering insight into the benefits of organic and disproportionate risks to farmers using chemical-intensive methods. The results further reveal prevalent environmental pesticide mixtures, in addition to highlighting exposure to current-use pesticides (CUPs) and legacy (banned) pesticides that occurs through multiple exposure routes to workers, residents, and consumers. “Our study offers a comprehensive analysis of non-dietary pesticide exposure patterns among various populations across the EU [European Union], underscoring its widespread prevalence and identifying significant occupational and residential predictors,” the authors explain. As pesticide exposure occurs through both dietary and nondietary routes, such as through dermal (skin) contact and inhalation of contaminated air, there “is a growing need for aggregated [total; combined] exposure estimates across occupationally and nonoccupationally exposed populations.” The study includes testing for 193 pesticides, both legacy pesticides and CUPs, captured in silicone wristbands worn by farmers, residents living close to treated fields (neighbors), and the general population (consumers) in […]

(Beyond Pesticides, October 6, 2025) [Comments are due by 11:59 pm ET on October 8, 2025.] As the public comment period for the upcoming National Organic Standards Board (NOSB) meeting closes on October 8 at 11:59pm, under consideration is an issue that goes to the heart of organic integrity—contamination-free compost. In response to a petition from the Biodegradable Products Institute (BPI), a certifier of packaging and products for commercial composting, the NOSB’s Crops Subcommittee (CS) voted to keep synthetic compostable materials out of compost permitted in certified organic production. According to comments submitted by Beyond Pesticides, compost from plant and animal materials is of fundamental importance to organic practices. Composting is one way that organic growers meet the requirement in law to “foster soil fertility, primarily through the management of the organic content of the soil through proper tillage, crop rotation, and manuring.” The integrity of organic production has always been tied to the integrity of compost. Beyond Pesticides provides the public with comments on all the issues before the NOSB, which can be accessed here: Keeping Organic Strong and the Fall 2025 issues page. (The organization urges members of the public to copy and paste from the issues below or Fall 2025 […]

(Beyond Pesticides, October 2, 2025) This year marks an advancement of various state-level neonicotinoid laws and regulations, including in Maine, Vermont, and Connecticut—emphasizing surging public support for pesticide reforms. The Maine legislature passed, and Governor Janet Mills (D-ME) signed into law on July 22, 2025, LD 1323, which commissions the Board of Pesticide Control to study the impacts of neonicotinoids and neonicotinoid-treated seeds, which advocates hope will help advance future legislation to prohibit the use, distribution, and sale of neonicotinoid insecticide products. Meanwhile, after years of grassroots advocacy, the Connecticut legislature advanced, and Governor Ned Lamont (D-CT) signed SB 9 into law, which will partially restrict the nonagricultural use of neonicotinoids on turfgrass, starting in 2027. There was a more comprehensive effort that failed to move forward (HB 6916), which would have gone further by restricting or prohibiting the use of neonicotinoids on trees, shrubs, and treated seeds (see here for Beyond Pesticides comments). Maine and Connecticut join eleven other states (California, Nevada, New Jersey, Massachusetts, Maryland, Minnesota, New York, and Vermont) in taking steps to restrict or prohibit the use of neonicotinoids. (See Daily News here.) Whether it is a campaign to ban glyphosate, paraquat, chlorpyrifos, atrazine, or any […]

(Beyond Pesticides, October 1, 2025) A novel study in Scientific Reports combines computational analyses with toxicological data to identify pathways affected by exposure to the weed killer glyphosate. The analyses identify glyphosate targets that correlate with kidney injury and kidney cancer, revealing pathways with significant glyphosate-induced alterations, including the dysregulation of nitrogen metabolism that leads to ammonia accumulation and oxidative stress, both of which contribute to renal (kidney) damage and carcinogenesis (development of cancer). “This study provides a comprehensive investigation into the molecular mechanisms by which glyphosate may contribute to kidney injury and kidney cancer, employing an array of bioinformatics tools for target prediction, toxicity assessment, pathway enrichment analysis, molecular docking and molecular dynamics simulation,” the researchers state. The results of the analyses and simulations highlight the molecular mechanisms underlying glyphosate’s nephrotoxic (damaging to kidneys) and carcinogenic (cancer-causing) effects. Study Importance and Background Glyphosate, known as a broad-spectrum systemic herbicide, has been used for agricultural and nonagricultural purposes for decades and is the most extensively used herbicide worldwide. This widespread use is largely due to its application to genetically engineered, glyphosate-tolerant crops. Both glyphosate and its main metabolite (breakdown product), aminomethylphosphonic acid (AMPA), are detected in water, soil, and food, […]