(Beyond Pesticides, January 13, 2026) An important study in Nature Microbiology challenges the entrenched assumption in the chemical industry and among regulators that synthetic chemicals can be targeted for specific uses and have limited effects beyond those uses. The categorization of chemicals into pharmaceuticals, pesticides, and industrial chemicals masks their commonalities and combined potential for deep harm to biological systems. In particular, the effects of the onslaught of xenobiotics (not naturally produced) on human gut microbiota are of increasing concern. The study, by an international team including researchers at the National Institute of Environmental Health Sciences, Cambridge University, and Heinrich Heine University in Germany, tested a set of xenobiotics, including pharmaceutical, pesticide, and industrial compounds, against 22 human gut bacteria. Using both in silico (computers) and in vitro (laboratory experiments), they found 168 chemicals that exerted inhibitory effects on the gut bacteria. Most of these interactions had not been previously reported. Of the xenobiotic categories, fungicides and industrial chemicals were the most influential. The researchers note that the “pervasive use” of synthetic chemicals “and environmental persistence have led to pollution levels exceeding the planetary boundary for stable and resilient Earth systems” [emphasis added] and that “safety assessments for these chemicals […]

(Beyond Pesticides, December 15, 2025) With recent proposals by the U.S. Environmental Protection Agency (EPA) to register new pesticides that under international standards are classified as PFAS (Per- and Polyfluoroalkyl Substances), people and organizations are calling for Congress to reverse the agency’s action. Beyond Pesticides announced an action to Tell EPA and Congress to eliminate PFAS chemicals, including those used in pesticides.  In its action Beyond Pesticides pointed to the long history of allowing pesticides on that market that have long residual lives and bioaccumulate in the environment, causing generations of exposure and adverse effects to health and ecosystems. DDT (Dichlorodiphenyltrichloroethane) exemplifies the generational effect of a toxic pesticide whose effects ha endured for decades, even though it was hailed as a miracle solution for agriculture and public health. PFAS, with a wide variety of uses—from nonstick pans to waterproofing fabrics to firefighting foams to pesticides—might similarly lead to the characterization as a “miracle” chemical. PFAS also share the less beneficial characteristics of DDT. Like DDT, PFAS are persistent, leading to the nickname “forever chemicals,” and they are highly toxic. EPA links PFAS to an increased risk of many health effects, including decreased fertility and hypertension in pregnant people; increased risk of prostate, […]

(Beyond Pesticides, December 4, 2025) In a news release last week on November 26, 2025, the U.S. Environmental Protection Agency (EPA) “issued a comprehensive fact-check addressing dangerous misinformation circulating about EPA’s recent pesticide approvals” that, according to health and environmental advocates, continues to deceive the public about the true risks for health and the environment from petrochemical pesticides including, but not limited to, per- and polyfluoroalkyl substances (PFAS). Also published on November 26, coverage titled The EPA Is Embracing PFAS Pesticides. These Are The Health Risks in Time further highlights EPA’s deficiencies and the threats of PFAS, which Beyond Pesticides has extensively covered. (See here and here.)  The controversy erupted as a result of EPA’s latest proposal to allow a new fluorinated pesticide to the list of four other similar compounds now widely available for use in homes and gardens, buildings, and agriculture. The newest pesticide proposed for EPA registration, epyrifenacil (agricultural weed killer), joins cyclobutrifluram (soil fungicide/nematicide), isocycloseram (household and agricultural insecticide), diflufenican (lawn and agricultural weed killer), and trifludimoxazin (agricultural weed killer), making a total of five PFAS pesticide proposals this year that have been associated with national and worldwide contamination of food, land, and water. Two of these, cyclobutrifluram and isocycloseram, have been approved. “Instead of constraining the use of fluorinated pesticides—persistent and highly toxic […]

(Beyond Pesticides, December 2, 2025) Recently published in Reproductive Toxicology, researchers in Denmark and Iceland investigate the impacts of pesticides on sex hormones, finding that “prenatal exposure to [the insecticide] chlorpyrifos and [weed killer] 2,4-D may affect the reproductive hormones in girls, but not boys, during minipuberty, which may have long-term implications.” Based on their analysis of urinary maternal concentrations of the pesticides and their metabolites and hormone levels in infants, the authors report, “This study examined the association between maternal pesticide exposure and pituitary, gonadal, and adrenal hormones in offspring during infancy.” The sex-specific findings highlight a public health concern with potentially long-lasting transgenerational effects. “We recruited pregnant women from 2010 to 2012 in the Odense Child Cohort, including 489 mother-child pairs,” the authors state. They continue: “Maternal urinary concentrations of the generic pyrethroid metabolite 3-phenoxybenzoic acid (3-PBA), the chlorpyrifos metabolite 3,5,6-trichloro-2-pyridinol (TCPY), and the herbicide 2,4-D were measured at gestational week 28. Serum concentrations of luteinizing hormone (LH), follicle stimulating hormone (FSH), testosterone (T), estrone (E1), estradiol (E2), 17-hydroxyprogesterone (17-OHP), Androstenedione (Adione), and Dehydroepiandrosterone sulfate (DHEAS) were assessed in infancy.” The results of the analyses show that in girls, higher maternal urinary TCPY and 2,4-D concentrations are significantly […]

(Beyond Pesticides, November 25, 2025) Chemical pollution is having a profound impact on men’s overall health and reproductive function. Endocrine-disrupting chemicals—which prominently include pesticides—are a major factor. The Health and Environment Alliance (HEAL) a European organization funded by the European Union (EU) and several private foundations, has issued a strong call for attention to – and action on – the precipitous decline in male reproductive health owing to chemical exposures, including pesticides. In a new report, Chemical pollution and men’s health: A hidden crisis in Europe, the group states, “The scientific evidence is clear. The costs of chemical pollution – human and economic – are mounting. The solutions exist. What we need now is the political will to act.” The report was written by Rosaella Cannarella, M.D., PhD, an endocrinologist at the Division of Endocrinology, Metabolic Diseases and Nutrition, University of Catania (Italy). HEAL’s report details alarming indications of catastrophe in male reproductive health: prostate cancer, testicular cancer, crashing sperm counts, and numerous developmental problems including cryptorchidism, urogenital malformations, and hypospadias. The report highlights pesticides, microplastics, phthalates, bisphenols, PFAS and heavy metals as the likely environmental sources of the crisis. There is evidence that all of these endocrine disrupting chemicals […]

(Beyond Pesticides, November 21, 2025) “How do we respond when told that the solution to ubiquitous and hazardous toxic chemicals in our lives (in our air, food, water, soil, on farms, in parks, playing fields, and schoolyards) is a reduction in their use that continues to allow unnecessary toxic chemical dependency and poisoning?  Do we accept partial restrictions of pesticide use, despite the availability of cost-effective alternatives that stop the toxic assault and help to prevent the most serious associated diseases that invade and attack our bodies, our loved ones, our families, and our communities—with breast cancer, prostate and testicular cancer, pediatric cancer, infertility, and more?”   These are the questions being asked about the most prevalent cancers in the U.S. and worldwide at the upcoming 2nd Session of the National Forum, The Pesticide Threat to Environmental Health: Advancing Holistic Solutions Aligned with Nature, scheduled for December 4, 1:00-3:30pm (EST).  ‍️➡️ Link to register The Forum brings together cutting-edge science and medical experts from Brazil, Italy, Belgium, Rwanda, Canada, and the United States to sharpen the voices of advocates who are saying that the time for action to eliminate the current reliance on petrochemical pesticides and fertilizers is past due […]

(Beyond Pesticides, November 20, 2025) Recent scientific literature finds heightened toxicity associated with pesticide metabolites, the transformation/breakdown products of the parent compounds, that threaten the health of the soil, wildlife, and humans. This research stresses the importance of the U.S. Environmental Protection Agency (EPA) evaluating metabolites, which is currently insufficiently included in regulatory processes. In a literature review in Global Change Biology, the researchers point out multiple areas in which regulations fail to address key criteria, including metabolites, saying: “Pesticide risk assessments currently rely on surrogate species and focus primarily on acute lethality metrics, failing to capture the broader impacts on non-target organisms and thus biodiversity. Under the directives of regulatory agencies worldwide, this traditional approach overlooks the complex interactions between multiple stressors, including climate change, land-use shifts, and pesticide transformation products. Pesticide risk assessments must therefore undergo a paradigm shift to account for these complex interactions, which disproportionately affect insect pollinators, other non-target species, and biodiversity at large.” A metabolite is a breakdown product that forms when a pesticide is used in the environment and mixes with air, water, soil, or living organisms. All metabolites fall under the category of transformation products, which is the broader term for any […]

(Beyond Pesticides, October 29, 2025) A study published in Environment International evaluates residues of individual and mixtures of endocrine-disrupting chemicals (EDCs), including pesticides, and finds an association between exposure and hyperactive behavior in children. The researchers evaluated urine samples from over 800 preschoolers, identifying and statistically analyzing concentrations of 22 EDCs, and finding that nine of these chemicals are significantly associated with hyperactivity trajectories and EDC mixtures are positively associated with hyperactive behavior, noting the strongest association in girls.  “The current study indicates the adverse health effects of exposure to mixtures of EDCs among preschoolers, and suggests gender specificity in these effects,” the researchers state. They continue, “This highlights the importance of focusing on multi-pollutant exposure in early childhood.”  Study Importance  “Attention-deficit/hyperactivity disorder (ADHD) is a common neurodevelopmental disorder in children, which has become one of the main factors leading to the burden of disease in children and adolescents worldwide.” The authors continue: “Its core symptoms are high levels of inattention and/or hyperactivity/impulsivity during the preschool period. A meta-analysis showed that the overall prevalence of ADHD in children in China over the past 15 years was as high as 6.2%, and has been increasing over recent years.”  In comparison, according […]

(Beyond Pesticides, October 27, 2025) With the confluence of science and law, the spotlight is on sewage sludge fertilizer and its contaminants, including per- and polyfluoroalkyl substances (PFAS). Sewage sludge (biosolids) is a byproduct of sewage treatment and is used as a source of organic matter for amending soil in nonorganic agriculture and landscaping. In light of a recent settlement in a lawsuit filed by Beyond Pesticides against ScottsMiracle-Gro, ongoing litigation against GreenTechnologies, LLC, and a major study identifying 414 contaminants of emerging concern (CECs), Beyond Pesticides’ network is calling on Governors and local officials to ban the use of biosolids on farms and parks, until there is adequate testing of toxic residues—which does not currently exist.   The lawsuits against producers of sewage sludge fertilizer cite test results showing PFAS residues in the companies’ products and numerous scientific studies on the adverse effects of PFAS to public health, wildlife, and pollinators. (See settlement statement recently reached with ScottsMiracle-Gro.)  A literature review published in Frontiers in Environmental Chemistry identifies CECs in soils, untreated and treated sewage sludge (biosolids), and dust, across 151 peer-reviewed studies released between 2018 and 2023—emphasizing the range of potential exposure pathways across various products, including classes of pesticides like neonicotinoid insecticides. […]

(Beyond Pesticides, October 22, 2025) The release of scientific studies on contaminants in sewage sludge (biosolids) used as fertilizers coincides with two lawsuits filed by Beyond Pesticides against ScottsMiracle-Gro and GreenTechnologies, LLC, in which the organization alleged that each defendant engaged in false and deceptive marketing and sale of fertilizer products that were marketed as environmentally friendly, despite containing per- and polyfluoroalkyl substances (“PFAS”). PFAS have been linked to cancer and other adverse effects. (See settlement statement recently reached with ScottsMiracle-Gro.) Biosolids are widely used in agricultural production and nonagricultural land management, including parks and playing fields, but  prohibited from use in certified organic agriculture under the Organic Foods Production Act. Two recent studies raise serious concerns about a range of contaminants in treated sewage sludge. While widely advanced as supplementing organic matter with macro- and micro-nutrients, treated sludge “harbor[s] a concentrated presence of contaminants that have adsorbed onto the soil post-wastewater treatment,” according to a literature review published in Frontiers in Environmental Chemistry. The researchers identify 414 contaminants of emerging concern (CECs) in soils, untreated and treated sewage sludge (biosolids), and dust, across 151 peer-reviewed studies released between 2018 and 2023—emphasizing the range of potential exposure pathways across various […]

(Beyond Pesticides, October 15, 2025) The latest Scientific Investigations Report for 2025 from the U.S. Geological Survey (USGS), entitled “National Water Quality Program: Multidecadal Change in Pesticide Concentrations Relative to Human Health Benchmarks in the Nation’s Groundwater,” finds moderate concentrations of five pesticides, with the highest percentages in agricultural wells, and concentrations of the carcinogenic soil fumigant DBCP (1,2-dibromo-3-chloropropane), which also causes infertility, that are greater than the maximum containment level, despite being banned over 45 years ago. These results highlight the persistence of pesticides used in agriculture and the elevated risks of pesticide contamination in agricultural areas. This report monitors concentrations of pesticides in well networks across the U.S. in decadal intervals, with this last one incorporating data ranging from 1993-2023. Additionally, DBCP in one well network in the San Joaquin-Tulare River Basin in California continues to be assessed due to previous levels exceeding the human health benchmark (HHB) established by the U.S. Environmental Protection Agency (EPA). The limitations of the study are disclosed in the text of the report. As the authors state: “Only pesticides with an HHB were included in the multidecadal pesticide change analysis… The total number of pesticides included in this study is less than […]

(Beyond Pesticides, October 7, 2025) Published in Environment International, a study utilizing silicone wristbands provides a snapshot of chemical exposure in over 600 participants across 10 European countries. Using the wristbands as passive and noninvasive samplers, the researchers find that organic farmers’ wristbands contain lower pesticide levels than other groups, offering insight into the benefits of organic and disproportionate risks to farmers using chemical-intensive methods. The results further reveal prevalent environmental pesticide mixtures, in addition to highlighting exposure to current-use pesticides (CUPs) and legacy (banned) pesticides that occurs through multiple exposure routes to workers, residents, and consumers. “Our study offers a comprehensive analysis of non-dietary pesticide exposure patterns among various populations across the EU [European Union], underscoring its widespread prevalence and identifying significant occupational and residential predictors,” the authors explain. As pesticide exposure occurs through both dietary and nondietary routes, such as through dermal (skin) contact and inhalation of contaminated air, there “is a growing need for aggregated [total; combined] exposure estimates across occupationally and nonoccupationally exposed populations.” The study includes testing for 193 pesticides, both legacy pesticides and CUPs, captured in silicone wristbands worn by farmers, residents living close to treated fields (neighbors), and the general population (consumers) in […]

(Beyond Pesticides, September 30, 2025)  A pioneering study has measured the concentrations of pesticides in clouds. Prior to this, rainwater has been tested and found to be a common depositor of pesticides. But there is far less information about the role of clouds themselves. The findings add to general scientific understanding that pesticides go everywhere: into soils, water bodies, and the bodies of plants and animals—even when they are not intentionally applied. There are many studies of pesticide concentrations, including their metabolites, so-called “inert” ingredients, and degradation products, in soil, water and the atmosphere. The study was published in Environmental Science & Technology last August by a team of scientists from the University of Clermont Auvergne and the Laboratoire Phytocontrol in France and the University of Torino in Italy. Clouds are collections of water droplets, as opposed to molecular gases or aerosols, which are simply fine particles or liquid droplets of any substance capable of becoming airborne. Aerosol and gas-phase chemicals are known to travel widely in the atmosphere and do not require the presence of water to do so. Contaminants in rain have been studied to some extent, but rain is a separate analytical category from clouds. A study […]

(Beyond Pesticides, September 25, 2025) Reinforcing numerous studies’ findings of widespread environmental contamination with PFAS (per- and polyfluoroalkyl substances), heavy metals, pesticide metabolites, and pharmaceuticals, researchers detected the chemicals in noncommercial backyard eggs laid in Greece, according to a study published in Science of The Total Environment. The researchers found that “[o]nly 9 out of 17 samples were compliant to the limit….set by the [European Union] for the sum of PFHxS [perfluorohexanesulfonic acid], PFOS [perfluorooctanesulfonic acid], PFOA [perfluorooctanoic acid], and PFNA [perfluorononanoic acid].” They continue: “[A]s regards PFOS, PFHxS, and PFNA, seven, six and one out of 17 samples, respectively, were above the ML (maximum limit) as set by the EU.” With current regulatory standards focused on evaluating exposure to individual chemicals and, in some instances, cumulative risk associated with chemicals that have a common mechanism of effect, this study points out the importance of looking at mixtures of chemicals and the potential synergistic effects. There are some fluorinated pesticides defined as PFAS due to their molecular structure and high toxicity, which makes the chemicals highly persistent in the environment. Center for Food Safety, Center for Biological Diversity, and Public Employees for Environmental Responsibility reviewed the full list of active […]

(Beyond Pesticides, September 18, 2025) Published in Environmental Toxicology and Pharmacology, a study of earthworms (Eisenia fetida) evaluates the toxicity of environmentally relevant levels of three fluorinated pesticides (fluxapyroxad, fluopyram, and bixafen) through a 56-day soil exposure experiment. The dose- and time-dependent results reveal that effects on growth and reproduction occur at elevated concentrations, with weight loss and reduced offspring occurring from energy depletion and reproductive organ damage. Other implications escalate with concentration as well, including antioxidant system failure and DNA damage. As the authors summarize, “These findings highlight the mechanisms of fluorine-containing pesticide toxicity in earthworms, emphasizing their potential to disrupt soil ecosystems.” Fluorine-containing pesticides are widely used in agriculture, yet the chronic effects on soil and soil organisms are not fully considered in regulatory review. Research comparing the similarities and differences in the impacts on nontarget organisms from fluorinated pesticides is lacking, with the current study beginning to address the urgent need to close this gap. “Data indicate that among more than 100 newly developed pesticides, fluorine-containing pesticides constitute nearly half, making them a focal point in the development of the global pesticide industry,” the researchers state. As representatives of the fluorinated pesticides class, particularly succinate dehydrogenase inhibitors […]

(Beyond Pesticides, September 12, 2025) A team of Argentinian researchers conducted a study published in Environmental Toxicology and Pharmacology of the combined effects of the herbicide glyphosate and the pyrethroid insecticide cypermethrin. The researchers observed significantly higher apoptosis in cells exposed to the mixtures than to the individual pesticides—a synergistic response. Apoptosis, also known as programmed cell death, is a standard way that tissues handle damaged cells to remove threats to their function. The researchers sought to investigate the cellular toxicity of each chemical, individually and in combination, and assessed whether the effects of the mixture were additive or synergistic. Additive effects occur when two individual chemicals amplify the same sort of response, often because the chemicals have similar structures. Synergism can occur when chemicals have different mechanisms of action but work together to create more powerful effects. Mixtures of pesticides are the least-studied area of research conducted for regulatory purposes. While regulators provide instructions to applicators regarding which pesticides can be applied together and combined in tank mixtures, there is no control over how pesticides travel through the environment once applied, as they flow through the air as spray drift, lodge in soils and water, and are incorporated into […]

(Beyond Pesticides, September 10, 2025) After being criticized by the chemical industry and allied agribusiness and service industry groups on the Make America Healthy Again (MAHA) report in May, the strategy document, released yesterday, has tamped down efforts to reform government programs that regulate pesticides. There are no specific recommendations on improving the regulation of pesticides. Rather, the strategy appears to embrace business-as-usual and could even ramp up government efforts to tout the need for pesticides and claims that current regulatory reviews are effective and comprehensive. In a section of the strategy entitled “Increasing Public Awareness and Knowledge,” the document says: “EPA, partnering with food and agricultural stakeholders, will work to ensure that the public has awareness and confidence in EPA’s pesticide robust review procedures and how that relates to the limiting of risk for users and the general public and informs continual improvement.” This is at odds with the earlier MAHA assessment report which identified pesticides as substances of concern that, citing deficiencies in chemical reviews, “may be neglecting potential synergistic effects and cumulative burdens, thereby missing opportunities to translate cumulative risk assessment into the clinical environment in meaningful ways.” While the earlier report, Make Our Children Healthy Again: Assessment, […]

(Beyond Pesticides, September 8, 2025) Beyond Pesticides today called on Congress to require the U.S. Environmental Protection Agency (EPA) to incorporate real world science into its evaluation of pesticide safety calculations by recognizing that daily exposure involves multiple chemicals and synergistic interactions— a magnified effect greater than the individual chemical effects added together. The organization cites numerous scientific studies that call public attention to this issue; that a realistic assessment of the human and environmental harm potentially caused by pesticides cannot be evaluated based on single-chemical, single-species tests. Given the numerous complexities associated with this type of assessment, the group points to organic land management in agriculture and residential areas as a more cost-effective approach, sending this message to Congress: EPA must consider the effects of pesticides in the context in which they are used and with reference to the organic alternative. A recent study, covered by Beyond Pesticides in its Daily News, found that the presence of Varroa mites in combination with the neonicotinoid insecticide imidacloprid increases the risk of bee mortality and disrupts the larval gut microbiome. The study found synergy (a greater combined effect) between Varroa destructor, a parasitic mite that attacks and feeds on honey bees, and imidacloprid. The findings were published last […]

(Beyond Pesticides, September 3, 2025) A study in Environmental Entomology shows that habitat and open space near agricultural fields become a killing field of pesticides, threatening biodiversity due to contamination from toxic drift. The study detected 42 pesticides, including several neonicotinoids, which are among the most lethal threats to pollinators. The research reveals the complexity of pesticide flow through the environment and the inadequacy of current methods of protecting nontarget organisms, including honey bees, bumblebees, and hundreds of other species of native bees worldwide. Their catastrophic declines is tied to pesticides in large part and highlights the inadequacy of current pesticide reduction strategies, such as integrated pest management (IPM) and now other loosely defined concepts like “regenerative,” in an attempt to protect the environment and nontarget organisms in chemical-dependent land management and agriculture. (See What the Science Shows on Biodiversity.) The researchers on the study, from the U.S. Department of Agriculture, Cornell University and Michigan State University, put silicone bands on fence posts in open areas adjacent to highbush blueberry fields on 15 farms in western Michigan. Silicone takes up chemicals in the atmosphere which can then be extracted and analyzed. The fence posts were placed at seven intervals ranging […]

(Beyond Pesticides, September 2, 2025) It did not go without notice to U.S. grassroots environmental and public health advocates that earlier this month, over two million people in France signed a “first of its kind” petition that ultimately prevented the overturning of the country’s ban on bee-killing neonicotinoid insecticides. The action was widely covered in France, including in Le Monde. This uprising, organized by 23-year-old French master’s student Eleonore Pattery, emphasizes the importance of individuals in communities mobilizing people to protect the planet from pesticides that are having a devastating adverse effect on health and the environment. The grassroots push in France taps into a deep public concern about health and the environment that is emblematic of the level of public engagement needed to thwart the high level of chemical industry, agribusiness, and allied corporate influence that undermines basic protections. Industry interests have long been embedded in federal environmental and public health laws. For example, federal and state pesticide laws (the Federal Insecticide, Fungicide, and Rodenticide Act and similar state laws) allow widespread exposure to toxic chemicals despite the availability of nontoxic alternatives that are both efficacious and cost-effective. Without public engagement, as seen in France, significant improvements in law are constantly […]

(Beyond Pesticides, August 25, 2025) What the Republican-led Committee on Transportation and Infrastructure in the U.S. House of Representatives calls legislation to “Cut Red Tape and Increase Clean Water Act Permitting Efficiency” is being roundly criticized by environmental groups as an attack on the safety of the nation’s waterways. On June 25, the Committee passed the Promoting Efficient Review for Modern Infrastructure Today (PERMIT) Act, H.R. 3898, sponsored by Rep. Mike Collins (R-GA), which makes sweeping changes to the Clean Water Act (CWA) with serious consequences that will undermine water quality, pesticide oversight, and community right-to-know, according to environmental advocates. The PERMIT Act, now moving through Congress, is a package of over 15 anti-clean water bills and poses an extreme threat to clean water protections, thwarting to the goals of CWA.   Beyond Pesticides is calling on the public to Tell your U.S. Representative and Senators to oppose H.R. 3898, the “PERMIT Act.” Ever since CWA became law in 1972 to “restore and maintain the chemical, physical, and biological integrity of the Nation’s waters,” the definition of the “Nation’s waters,” aka “waters of the U.S.” or “WOTUS,” has been cloaked in controversy. This controversy is coming to a head again as the Trump administration revises regulations in […]

(Beyond Pesticides, August 14, 2025) A review in Clinical and Experimental Obstetrics & Gynecology links various classes of environmental pollutants including pesticides and per- and polyfluoroalkyl substances (PFAS), both of which Beyond Pesticides has extensively covered, to adverse effects on the female reproductive system and common mechanisms of toxicity. These chemicals “disrupt the hypothalamic-pituitary-gonadal axis (HPG), impair ovarian function, and contribute to reproductive dysfunction through mechanisms such as oxidative stress, hormonal disruption, and epigenetic [gene expression or behavior] modifications,” the authors say. This leads to menstrual irregularities, infertility, and pregnancy complications, as well as increases in the risk of reproductive system disorders such as endometriosis, polycystic ovary syndrome (PCOS), and ovarian cancer, among others. “Additionally, transgenerational effects mediated by epigenetic modifications, germ cell damage, and placental transfer may adversely affect offspring health, increasing the risk of reproductive dysfunction, neurodevelopmental disorders, metabolic diseases, and cancer,” the researchers explain. This study, integrating recent epidemiological and experimental findings, provides an overview of major chemical classes that threaten women’s health and highlights the need for immediate action. As the authors point out, female reproductive health is important not only for those who choose to plan for a family but also for the overall well-being […]

(Beyond Pesticides, August 13, 2025) The data on the adverse effects of the insecticide chlorpyrifos, still widely used in food production, continued to accumulate with the latest being a study published in PLOS One that finds perinatal exposure to the chemical in mice can alter sleeping patterns, lead to brain inflammation (particularly in female individuals), and impact gene expression linked to immune response and epigenetic effects. The adverse health effects are greater overall in female mice than male mice, emphasizing the significance of disproportionate impacts across species. Chlorpyrifos has been a threat to human and ecological health for decades, originally as a general-use pesticide for homes, gardens, and agriculture, and then restricted to most nonresidential uses in 2000. Currently, the chemical’s permitted uses include food and feed crops, golf courses, as a non-structural wood treatment, and adult mosquito control for public health (insect-borne diseases) uses only. According to health and environmental advocates, there is a long history of U.S. Environmental Protection Agency (EPA) failure to adequately protect human and environmental health from chlorpyrifos, which is linked to endocrine disruption, reproductive effects, neurotoxicity, brain, kidney, and liver damage, and birth and developmental effects. It took 21 years after negotiating a stop […]