(Beyond Pesticides, January 19, 2024) A study published in Environmental Health Perspective is one of the first to indicate a link between exposure to the herbicides 2,4-D and glyphosate and the impairment of behavioral performance (i.e., attention/inhibitory control, memory/learning, language, visuospatial processing, and social perception). These adverse effects associated with the neurotoxic impacts of pesticides on behavior have been previously documented. For example, a study in August 2023 finds oral intake (e.g., eating contaminated foods), inhalation, and dermal exposure to glyphosate lowered cognitive function scores, increased the likelihood of severe depressive symptoms, and impaired auditory (hearing) function. Although previous studies find neurotoxic effects from exposure to these herbicides, very few until now have evaluated how this neurotoxic exposure impacts neurotypical behavior among youth (children and teenagers). The ubiquitous use of glyphosate and 2,4-D use in agriculture—which leaves residues of the toxic chemicals in food and in public areas (e.g., parks and walkways) creates a creates a significant risk for exposure. Glyphosate is already implicated in or proven to lead to the development of numerous health anomalies, including cancer, while 2,4-D also has a range of potential hazards, including cancer. Therefore, studies like this help local and government officials make holistic decisions regarding the use […]

(Beyond Pesticides, January 10, 2024) Exposure to endocrine-disrupting chemicals (EDCs) negatively impacts testicular function and may cause sperm count declines over time, according to a 2022 review published in Endocrine. The findings indicate that this occurs regardless of whether exposure is prenatal (before birth) or postnatal (after birth). More recent work from October 2023 confirms the connection between male reproductive health and exposure to organophosphate and carbamate insecticides and the weed killer glyphosate—as many pesticide products containing these chemicals are classifiable as endocrine disruptors (ED). Just last year, a meta-analysis from researchers at Mount Sinai Medical Center, the Hebrew University of Jerusalem, and the University of Copenhagen, among others, finds that the drop in global sperm count is accelerating, dropping by 51.6 percent from 1973 through 2018. The U.S. regulatory system, under the authority of the U.S. Environmental Protection Agency (EPA), has not kept pace with the science and does not fully evaluate pesticides in wide use for endocrine disruption, despite a requirement in 1996 law (the Food Quality Protection Act) to begin that testing and evaluation nearly three decades ago. In 2021, Beyond Pesticides reported that the Office of the Inspector General (OIG) for EPA issued a damning report on the […]

(Beyond Pesticides, December 15, 2023) Drawing on a recent gathering of international scientists, a group of 34 scientists published a call for much stricter scrutiny of researchers’ conflicts of interest by agencies that regulate and register chemicals, with recommendations for the newly formed Intergovernmental Science Policy Panel. Writing in Environmental Science & Technology, the authors, led by Andreas Schäffer of Aachen University in Germany and Martin Scheringer of Masaryk University in the Czech Republic, cite an abundance of examples of chemical companies and their trade associations manufacturing doubt via an array of techniques, resulting in agencies such as the U.S. Environmental Protection Agency (EPA) dropping certain provisions from rulemaking, ignoring scientific consensus, and keeping chemicals on the market—and in the environment—that many scientists say should be entirely banned. The authors produced the article in response to this webinar to discuss how to ensure that U.N. panels dealing with global crises get the most sound scientific advice conducted by the International Panel on Chemical Pollution. Over the last four decades or so, the notion that conflicts of interest affect the validity of scientific research and professional opinions has been steadily eroded. Regulators wallow in compromised research, hamstrung by political pressure and […]

(Beyond Pesticides, December 13, 2023) A study published in Environmental Health finds occupational (work-related) exposure to pesticides increases the risk of endometrial (uterine) cancer development. Endometrial cancer is the most common cancer of the female reproductive system and the fourth most common cancer among women, primarily affecting the uterine lining rather than the uterus itself, like uterine sarcoma. Despite data predicting the disease rate to increase, few studies evaluate the connection environmental contaminants have on endometrial cancer occurrence. Like most cancers, non-genetic factors account for a majority of endometrial cancer risk, including diabetes, age, contraceptive (birth-control) use, and hormone (endocrine) disruption. However, three percent of all cases are hereditary, primarily from Lynch syndrome. The study notes, “Identifying other modifiable risk factors may help develop strategies to reduce the expected increasing incidence of these neoplasms.” Many pesticides have a long history associated with endocrine-disrupting properties that induce various molecular changes, prompting disease development. The International Agency for Research on Cancer (IARC) classifies many of these chemicals as potent carcinogens in animal studies. Cancer development also depends on genetic susceptibility, as impaired genes responsible for xenobiotic detoxification (elimination) increase disease risk sensitivity. Adding to the science, a review published in Environmental Exposure, Biomonitoring, and Exposure […]

(Beyond Pesticides, December 7, 2023) A new review published in Ecotoxicology reiterates what past studies have repeatedly stated: the herbicide paraquat (PQ) has profound adverse effects on wildlife at environmentally relevant concentrations. Moreover, these adverse effects span beyond the wilderness, as exposure to this highly toxic herbicide also impacts the health of people working with this chemical (e.g., pesticide applicators) or living adjacent to areas of chemical use. Current data gaps regarding the effects of environmentally relevant concentrations and exposure times, population- or ecosystem-level effects, and biomagnification potential contribute to the uncertainty of predicting risk from environmental PQ exposure. Furthermore, Beyond Pesticides has previously pointed out deficiencies in the U.S. Environmental Protection Agency’s (EPA) ecological risk assessments for paraquat, highlighting failures to perform complete evaluations of the impacts of pesticides on threatened and endangered species. All this occurs amid documented threats to biodiversity from the combined effects of pesticides and climate change.  The review investigated paraquat in the environment, the chemical’s toxicity to nontarget species, and significant data gaps. Overall, the long-term risks of environmental PQ contamination for human and ecological communities can be challenging since the potential chronic effects from extended use are nearly unstudied. Most concerning is that PQ is […]

(Beyond Pesticides, December 6, 2023) A study published in Antioxidants finds prenatal and early life exposure, usually after birth (perinatal), to glyphosate-based herbicides (GBH) induce oxidative stress in the brain, causing damage and negatively affecting melatonin levels. Melatonin is a hormone responsible for regulating circadian rhythm to mitigate sleep disorders. Disruption of melatonin levels also has implications for the development of age-associated neurodegenerative diseases, as melatonin is a neuroprotector against neurodegenerative diseases associated with aging. Additionally, GBH can alter molecules in the pineal gland in the brain, resulting in neurodegenerative diseases like Alzheimer’s disease (AD) and Parkinson’s disease (PD). Levels of inadequate sleep patterns are rising among the global population. Reports find variability in sleep duration results in higher rates of depression, anxiety, and fatigue. Since sleep is an essential factor in normal brain development, disturbance in sleep patterns, such as sleeping too much or too little, can result in long-term associations with the brain’s white matter integrity (responsible for age-dependent cognitive function). The study warns, “Since decreased levels of the important antioxidant and neuroprotector melatonin have been associated with an increased risk of developing neurodegenerative disorders, this demonstrates the need to consider the melatonin hormone system as a central […]

(Beyond Pesticides, December 1, 2023) Even though researchers have noted since the 1970s that human fertility appears to be declining globally, doubt is still circulating that it is really happening and that pesticides could have anything to do with it. Very recently published studies, however, make it clear that, even without exact elucidation of the mechanisms by which pesticides damage male fertility, there is an unmistakable association of pesticides and many aspects of male reproductive health. One of the new studies, a meta-analysis of 25 studies on the connection between pesticides and male reproductive problems, finds that men exposed to organophosphate (such as glyphosate and malathion) and carbamate (such as carbaryl and methiocarb) insecticides have lower sperm concentrations than the general population. This is especially true of men exposed in work settings. The senior author of the study, Melissa J. Perry,ScD of the George Mason University College of Public Health, told HealthNews, “The evidence available has reached a point that we must take regulatory action to reduce insecticide exposure.” Human infertility is defined as “the failure to achieve pregnancy after 12 months or more of regular unprotected sexual intercourse.” Most public attention regarding infertility focuses on women’s difficulties in getting […]

(Beyond Pesticides, October 18, 2023) A meta-analysis published in Toxics finds an association between exposure to organophosphate pesticides (OPs) and respiratory diseases and diabetes mellitus (DM). Specifically, wheezing and asthma are the most common respiratory manifestations of OP exposure, while fluctuation in weight and fat/glucose levels are the most common metabolically related manifestations. Organophosphorus pesticides have a wide range of biological uses—from insecticides to flame retardants—that make these chemicals ubiquitous, significantly contributing to ecosystem contamination. Thus, OP compounds have a global distribution, with evaporation and precipitation facilitating long-range atmospheric transport, deposition, and bioaccumulation of hazardous chemicals in the environment. Many studies show OPs are highly toxic, and residues are consistently present in human and animal urine, blood, tissues, and milk. Considering 90 percent of Americans have at least one pesticide compound in their body, primarily stemming from dietary exposure, including food and drinking water, advocates maintain that current restrictions on their use must adequately detect and assess total chemical contaminants.  This study investigated the effects and possible mechanisms involved in adverse health outcomes associated with OP exposure. Reviewing studies from Web of Science, PubMed, Embase, OVID, and the Cochrane Library, researchers systematically searched for articles on OP exposure and respiratory, DM, and cardiovascular disease (CVD) outcomes until 2022. […]

(Beyond Pesticides, October 12, 2023) A new study published in Environment International finds novel environmental chemicals (i.e., piperidine insecticide, 2,4-dinitrophenol, benzo[a]carbazole, and a benzoate derivative) involved in developing breast cancer through various inflammation pathways. These new potential factors contribute to breast cancer and highlight the importance of employing epidemiological biomonitoring like exposome (total exposure from birth to death) to discover mechanisms involved in disease development that are otherwise overlooked. According to the Centers for Disease Control and Prevention (CDC), breast cancer is a disease that causes breast cells to grow out of control, with the type of breast cancer depending on the cells themselves. Several studies and reports, including U.S. Environmental Protection Agency (EPA) data, identify hundreds of chemicals as influential factors (either promoting or initiating) associated with breast cancer risk. Breast cancer is the most common cancer among women, accounting for 12 percent of all new annual cancer cases worldwide and causing the second most cancer-related deaths in the United States. Past studies suggest genetic inheritance factors influence breast cancer occurrence. However, genetic factors only play a minor role in the incidence of breast cancer, while exposure to external environmental factors (e.g., chemical exposure) appears to play a more notable role. One in […]

(Beyond Pesticides, October 4, 2023) A study published in Food and Chemical Toxicology finds acute exposure to chlordane, an organochlorine insecticide, results in decreased lipid (fat) levels, altered anti-oxidant capacity, and increased testosterone levels (pro-androgenic) in male mice, while increasing liver enzyme activation and reducing regulation of both liver identity and function in females. These findings indicate that chlordane induces toxicant-associated steatosis (fat retention) liver disease (TASLD) with underlying, sex-specific, endocrine, and metabolic effects. It is well-known that traces of legacy (past-use) pesticides, like organochlorine pesticides (OCPs), remain in the environment for decades—possibly centuries, post-final application, as OCPs have greater chemical stability and gradual attenuation. However, these chemicals have profound adverse impacts on human health, especially on the endocrine system. Obesity, insulin resistance, type 2 diabetes, and elevated liver enzymes resulting from endocrine disruption contribute to liver diseases and can lead to liver cirrhosis. Although some, but not all, manufacturing and use of specific OCPs have declined in the U.S., OCPs remain a global issue, as much of the developing world still report usage. Considering the lack of studies on OCP-induced endocrine disruption, TASLD, and other liver diseases, research like this highlights the need to understand the underlying mechanisms contributing to […]

(Beyond Pesticides, October 2, 2023) On the 50th anniversary of the Endangered Species Act (ESA), statements out of the U.S. Environmental Protection Agency (EPA) raise concerns about the agency’s ability to meet the challenge of evaluating pesticides for their adverse impact on threatened and endangered species. While EPA has initiated efforts to address a significant backlog of pesticide evaluations, the agency faces a task so extensive that it may require several additional decades to fully catch up. EPA officials stated, “Even if EPA completed this work for all of the pesticides that are currently subject to court decisions and/or ongoing litigation, that work would take until the 2040s, and even then, would represent only 5 percent of EPA’s ESA obligations.”   As part of a “whole of government” approach, EPA must redirect its pesticide program to protecting all species and their habitats.   The speed and depth of biodiversity loss has reached crisis proportions. A 1,500-page report in 2019 by Intergovernmental Science-Policy Platform on Biodiversity and Ecosystem Services (IPBES )—Global Assessment Summary for Policymakers, the most comprehensive look to date at the biodiversity crisis and its implications for human civilization, makes the following finding: “Since 1970, trends in agricultural production, fish harvest, […]

(Beyond Pesticides, September 27, 2023) A study published in Pesticide Biochemistry and Physiology finds organophosphate (OP), organochlorine (OC), and pyrethroid (PYR) pesticides have links to insulin resistance (IR) associated with metabolic disorders like diabetes, obesity, chronic kidney disease (CKD), and hypertension. Metabolic disorders are among the leading causes of morbidity and mortality, with over 11 percent (>37 million) of individuals in the U.S. having diabetes, and cases are growing by millions annually. Additionally, there is a rise in metabolic disorders among young people. Studies even find low levels of pesticide exposure during pregnancy or childhood cause adverse health effects, including metabolic disorders tied to gut microbiome disruption (dysbiosis). With increasing rates of diabetes and obesity, the two most prominent metabolic diseases in the study, cases among the global population, studies like these highlight the importance of evaluating how chemical contaminants deregulate normal bodily function through metabolic changes.  To investigate the association between pesticide exposure and insulin-related metabolic disorders in humans, researchers searched the PubMed database for articles, performing a systematic review. The study notes, “IR is defined as a pathological state in which a higher-than-normal level of insulin is required to produce the optimal response in cells.” The search generated 4,051 articles related to the topic. However, after excluding duplicates and […]

(Beyond Pesticides, September 15, 2023) The U.S. Environmental Protection Agency suspended the registration of the herbicide dimethyl tetrachloroterephthalate (DCPA) (also widely known as Dacthal), effective August 22, 2023 and leaves existing stocks (products containing DCPA manufactured before August 22) available on the market. The decision is one of a series of EPA attempts dating to 2013 to get more data from the manufacturer as the agency considers reregistration of DCPA. The suspension is toothless, however, since EPA did not totally close the book on this chemical. Six days before the suspension, EPA signed a settlement agreement with the sole manufacturer, AMVAC Corporation, to reinstate the registration upon receipt of the complete toxicological data—that is, animal and laboratory tests— needed to determine the chemical’s safety and how and where it can be used. DCPA is currently classified by EPA as a possible human carcinogen and has also been shown to be a thyroid hormone disrupter. DCPA is regulated under the Federal Insecticide, Fungicide, and Rodenticide Act (FIFRA). Pesticides are supposed to undergo reregistration every 15 years to take new science into consideration, but this process is glacial. Congress amended FIFRA in 1988 to speed up reregistration of products registered before 1984, and […]

(Beyond Pesticides, August 16, 2023) A study published in Environmental Science and Pollution Research further supports the indication that exposure to organophosphate insecticides (OPs) increases the risk of asthma among the U.S. general population. According to the Asthma and Allergy Foundation of America, “The burden of asthma in the United States falls disproportionately on people with low-income, senior adults, and Black, Hispanic and American Indian/Alaska Native people,” making these groups more susceptible to developing this chronic lung disease upon OP exposure.   Organophosphorus pesticides have a wide range of biological uses—from insecticides to flame retardants—that make these chemicals ubiquitous, significantly contributing to ecosystem contamination. Furthermore, while organophosphates have less bioaccumulation potential, residues are consistently present in human and animal blood, urine, tissues, and milk. Although research demonstrates that OPs are highly toxic, there remains an inadequate understanding of how OP exposure impacts body systems like the repository system. The respiratory system is essential to human survival, regulating gas exchange (oxygen-carbon dioxide) in the body to balance acid and base tissue cells for normal function. However, damage to the respiratory system can cause several issues—from asthma and bronchitis to oxidative stress that triggers the development of extra-respiratory manifestations like rheumatoid arthritis and cardiovascular disease. Therefore, the rise in respiratory illnesses and organophosphate […]

(Beyond Pesticides, August 14 2023) The Protect America’s Children from Toxic Pesticides Act of 2023 (PACTPA), introduced on July 28, 2023 in the U.S. House of Representatives (H.R. 5085) and previously introduced on February 2, 2023 in the U.S. Senate (S.269), seeks to improve federal pesticide law. Many advocates, while endorsing the Congressional effort, maintain that the law (Federal Insecticide, Fungicide, and Rodenticide Act—FIFRA) is structurally flawed in not requiring restrictions and the elimination of pesticides for which there are safer alternative practices and products. A key provision in the legislation includes language that affirms local authority to restrict pesticides. Both the House and Senate bills retain the basic structure of FIFRA, while strengthening various aspects of the current risk assessment-based approach to pesticide restrictions. Risk assessment in the current policy context assumes that pesticides are necessary and sets allowable levels of harm based on inadequate information on chemical effects—and margins of safety that allow for numerous uncertainties and disproportionate effects to vulnerable population groups. Importantly, the legislation does include a provision that grants communities local authority to restrict pesticides on all property, public and private, within their jurisdiction, allowing towns, cities, and counties to move society away from pesticide dependency and […]

(Beyond Pesticides, August 4, 2023) The results of an Australian study published in Nature strike a contrast between land and water contamination with pesticide active substances (PAS), highlighting contamination as pesticides are transported through waterways.  The study results on water transport raise serious contamination issues. Only about one percent of the pesticides entering rivers degrade, so that long stretches of waterways and the oceans suffer the direct impact of a pesticide’s active ingredient. The lack of degradation also means that water organisms are being exposed to levels of pesticides exceeding many of the regulatory threshold limits set by governments. Although observation data are highly variable, the authors note that measured concentrations of pesticides in some river reaches of North America, East Asia and Europe exceed one or more regulatory threshold limits “at least once a year.” Further, the pesticides can bioaccumulate at each level of the aquatic food web, which can multiply concentrations by a thousand or more in the highest trophic levels, according to the study authors. The study finds that more than four-fifths of PAS are degraded in the soil, leaving about 10 percent of the original chemical in the soil as residue. Nearly half of that residues […]

(Beyond Pesticides, July 13, 2023) A study published in Environmental Science and Pollution Research finds exposure to p-Dichlorobenzene (p-DCB), a chlorophenol compound with uses as an insecticide, disinfectant, repellent, fumigant, fungicide, and deodorizer, can increase the risk of common endocrine (hormone)-mediated reproductive cancers (i.e., breast, uterine, and ovarian) in women. P-DCB or paradichlorobenzene has carcinogenic (cancer-causing) properties and the chemical has been banned in the European Union (EU) since 2005 for air fresheners and 2008 for mothballs. Being a chlorinated aromatic hydrocarbon (with benzene) compound (chlorobenzene), in addition to its cancer-causing properties, p-DCB can cause acute illnesses like headaches, numbness, sleepiness, nausea and vomiting and chronic effects like nervous system disorders leading to depression, and impact on the brain, birth outcomes, reproductive system, liver, and kidneys. Pesticides have a long history associated with endocrine-disrupting properties that induce various molecular changes, prompting disease development. Adding to the science, a similar review published in Environmental Exposure, Biomonitoring, and Exposure Assessment highlights how specific estrogen-mimicking pesticides increase the risk of disease, particularly hormone-related cancers among women (e.g., breast, ovarian, and endometrial cancer) and men (i.e., testicular, prostate cancer).PDCB, also known as para-dichlorobenzene, contains the carcinogen benzene and is chlorine-based (a chlorinated aromatic hydrocarbon compound), which in December 2019 […]

(Beyond Pesticides, June 27, 2023) Pesticides interfere with biological processes. This is their purpose. Unfortunately, they nearly always have unintended consequences, many of which have been ignored by their manufacturers. A new review article by Irish and Dutch researchers in the ISME Journal adds to the emerging scientific literature examining how pesticides affect the relationship between the human gut and the human brain (the “gut-brain axis”). Often called the “second brain” because it houses nerve cells and produces neurotransmitters, the gut-brain axis may be the most important locus where microbes and pesticides meet. The human gut plays host to a variety of microorganisms, ranging from bacteria and archaea to fungi, viruses and yeasts.[1] In a healthy person these microbes remain in balance and often cooperate both with each other and with human cells. The gut and the brain are deeply integrated through the vagus nerve and the neuroendocrine system. The vagus nerve is a treelike bundle of fibers extending from the lower part of the brain to nearly every body organ, but particularly the heart, lungs and digestive tract. The neuroendocrine system comprises specialized cells inhabiting nearly all the organs of the body that respond to signals from the brain […]

(Beyond Pesticides, June 14, 2023) A study published in Scientific Reports finds a link between pesticide exposure and recurrent pregnancy loss (RPL) through oxidative stress and apoptosis (cell death) in the placenta. Recurrent pregnancy loss (RPL) is the loss of three or more successive pregnancies before 24 weeks of gestation (pregnancy) and signifies an underlying reproductive health issue. The study highlights that pesticides’ endocrine-disrupting (ED) properties can have varying adverse impacts on biological processes, including immunology, metabolism, and reproduction. Pregnant women experience frequent exposure to environmental pollutants that pose serious health risks to both mother and newborn. Many known pollutants (e.g., heavy metals, polychlorinated biphenyl, and pesticides) are chemicals with ED properties that can move from the mother to the developing fetus at higher exposure rates. Additionally, pregnant women are experiencing exposure to an increasing number of dangerous industrial chemicals. With a range of scientific data highlighting chemical exposures during pregnancy as a critical window of vulnerability, public awareness of these threats is growing. The study notes, “They are associated with an increasing placental OS [oxidative stress] and placental apoptosis. Specific measures should be taken to decrease maternal exposure to these pollutants’ sources, especially in underdeveloped and developing countries.” For RPL, the research investigated pesticide components in blood plasma, […]

(Beyond Pesticides, June 9, 2023) Glyphosate, usually marketed as the herbicide Roundup, has long been the poster child for shoddy regulation by both the U.S. Environmental Protection Agency (EPA) and the European Food Safety Authority (EFSA). In a study published June 1, 2023 in Environmental Health by Axel Mie and Christina Rudén, PhD, of Stockholm University and the Centre for Organic Food and Farming in Uppsala, the authors followed up on earlier work that documented deficiencies in information provided to European Union (EU) regulators by manufacturers. They identified nine studies on developmental neurotoxicity (DNT) that had been submitted to the U.S. Environmental Protection Agency (EPA) but were not disclosed to EU authorities. According to the research, seven of these studies would have “actual or potential regulatory impact.” According to the authors: “Of the nine undisclosed DNT studies, three were sponsored by Bayer and performed in their own laboratory. Three studies were sponsored by Syngenta and performed in their Central Toxicology Laboratory. One study each was sponsored by Nissan Chemicals and Ishihara Sangyo Kaisha (ISK), and these were performed at Huntingdon Life Sciences. For the remaining study, the sponsor and laboratory are unknown to us.” This study is a new example […]

(Beyond Pesticides, June 2, 2023) Scientists have identified 97 different types of pesticides and flame retardants in primate fecal samples, recently reporting their results in the journal Biology Letters. In Uganda’s Kibale National Park, researchers studied the chemical exposure of four species of primates (chimpanzees, Ugandan red colobus, olive baboons and red-tailed monkeys), adding to previous research on the subject. The chemicals demonstrate a measurable effect on primate growth and development, sparking considerable unease as to the future health of these critical species. This study shows how even within a protected national park, wildlife species are at risk from chemical pollution. According to advocates, the use of dangerous pesticides and flame retardants, therefore, must be entirely stopped in order to protect the future viability of wildlife species.  Scientists collected a total of 71 fecal samples from the four chosen species to measure levels of chemicals and hormones in a noninvasive manner. After sample analysis, researchers highlight three main groups of chemical pollutants: organochlorine pesticides (OCPs), brominated flame retardants (BFRs), and organophosphate esters (OPEs). Although in a protected area, wildlife species encounter humans through tourism, research, and human development surrounding the park. As these pesticides are so prevalent in areas of […]

(Beyond Pesticides, May 30, 2023) On Endangered Species Day, May 19, the U.S. Environmental Protection Agency (EPA) revealed an unfortunate degree of hypocrisy in its claims to protect endangered species from pesticides. Tell EPA and Congress that dwindling biodiversity is an existential crisis that requires removing serious threats posed by pesticides. EPA announced that it “is publishing a group of StoryMaps to raise public awareness about protecting endangered species from pesticides.” It continues, “Through its Vulnerable Species Pilot, EPA has been identifying endangered species that are vulnerable to pesticides, developing mitigations to protect them from pesticide exposure, and will apply the mitigations to many types of pesticides.” However, pesticide use is a major cause of declining biodiversity, which is manifested in extinctions, endangered species, and species vulnerable to environmental disturbances—including climate change, habitat fragmentation, and toxic chemicals. If EPA is serious about protecting biodiversity, it must look first at the ways it has created the crisis in the first place. Studies upon studies upon studies show that pesticides are a major contributor to the loss of insect biomass and diversity known as the “insect apocalypse,” particularly in combination with climate change. Insects are important as pollinators and as part of […]

(Beyond Pesticides, May 25, 2023) A review of scientific literature published in the Journal of Endocrinological Investigation demonstrates exposure to past and current-use endocrine-disrupting chemicals (EDCs), like pesticides, have a long history of severe adverse human health effects. Endocrine disruptors are xenobiotics (i.e., chemical substances like toxic pesticides foreign to an organism or ecosystem) present in nearly all organisms and ecosystems. The World Health Organization (WHO), European Union (EU), and endocrine disruptor expert (deceased) Theo Colborn, Ph.D., classify over 55 to 177 chemical compounds as endocrine disruptors, including various household products like detergents, disinfectants, plastics, and pesticides. Endocrine disruption can lead to several health problems, including hormone-related cancer development (e.g., thyroid, breast, ovarian, prostate, testicular), reproductive dysfunction, and diabetes/obesity that can span generations. Therefore, studies related to pesticides and endocrine disruption help scientists understand the underlying mechanisms that indirectly or directly cause infertility, among other health issues. The review notes, “New evidence supports the role of other EDCs as possibly carcinogenic and pregnant women should avoid risk area and exposure. The relationship between EDCs and cancer supports the need for effective prevention policies increasing public awareness.” The review examines the relationship between EDCs and various hormone-mediated various (i.e., breast, prostate, testicle, ovary, and thyroid) to determine the carcinogenicity of the chemicals and their impact on public […]