(Beyond Pesticides, August 24, 2016) Researchers at Drexel University report that higher levels of some organochlorine compounds during pregnancy are associated with autism spectrum disorder (ASD) and intellectual disability (ID). The organochlorine compounds under study have long been banned in the U.S., and include pesticides like DDT, underscoring how pervasive and persistent these chemicals are, and their continued impact on human health. The research is reported in the study  Polychlorinated Biphenyl and Organochlorine Pesticide Concentrations in Maternal Mid-Pregnancy Serum Sam ples: Association with Autism Spectrum Disorder and Intellectual Disability,  which examines whether prenatal exposure to polychlorinated biphenyls (PCBs) and organochlorine pesticides (OCPs) influences offspring risk of ASD and intellectual disability without autism (ID). According to the research, children born after being exposed to the highest levels of organochlorines during their mother’s pregnancy are roughly 80 percent more likely to be diagnosed with autism when compared to individuals with the very lowest levels of these chemicals. The team looked at a population sample of 1,144 children born in Southern California between 2000 and 2003. Data was accrued from mothers who had enrolled in California’s Expanded Alphafetoprotein Prenatal Screening Program, which is dedicated to detecting birth defects during pregnancy. Participants’ children were […]

(Beyond Pesticides, August 22, 2014) The Town Board in Wheatfield, New York unanimously voted last month to amend its biosolids law to ban any application of sewage sludge and other similar materials from the treatment of municipal wastewater to any land in town, even for those who already have permits from the state. The law reasons that the potential contamination of groundwater, surface water, and soil, as well as the potential for air pollution, poses an unreasonable risk to town residents, public health, and the environment. Biosolids, otherwise known as sewage sludge, are composed of dried microbes previously used to process wastewater in treatment plants. The material is increasingly being used in conventional agriculture, but its application is explicitly forbidden in organic production. This is because the sludge can contain high concentrations of toxic contaminants, such as pesticides, detergents, estrogenic hormones, antibiotics, dioxins, PCBs, flame retardants, and heavy metals. A 2002 study revealed the material to be associated with an increased prevalence of Staphylococcus aureus infections, a condition known to cause skin rashes and respiratory problems, for people located in close proximity to biosolid application sites. More recently, new research adds to existing evidence of the hazards of sewage sludge […]

(Beyond Pesticides, February 13, 2013) After years of scrutiny and criticism, the U.S. Environmental Protection Agency’s (EPA) Administrator Lisa P. Jackson signed amendments strengthening existing standards for human research involving pesticides submitted by third parties for consideration in EPA decisionmaking. These amendments apply to studies involving the controlled exposure of participants to pesticides, with the hope that these “tougher” new standards will decrease the number of intentional human dosing studies conducted for pesticides. Even though EPA stated in 2001 that it will not consider or rely on human studies in its regulatory decisionmaking, subsequent industry pressure resulted in EPA invoking the Common Rule (40 CFR 26 – Protection of Human Subjects) for third-party intentional dosing studies. The agency promulgated new rules and made revisions to these rules, stemming from the lawsuit and settlement by the Natural Resources Defense Council (NRDC) et al., to broaden and refine rules relating to human research involving pesticides. In 2010, EPA published the proposed rule to amend EPA’s protocol for the testing of pesticides on humans. Now finalized, the rule strengthens EPA’s 2006 rule, Protections for Subjects in Human Research. Now prohibited is testing on nursing and pregnant women, children, as well as testing on […]

(Beyond Pesticides, January 16, 2013) Children living near chemical-intensive or conventional plantations in Costa Rica are exposed to twice as much of the insecticide chlorpyrifos compared to children living near organic plantations, a study reports. More than half the children, mostly from indigenous tribes- Ngäbe and Bribri – have a  higher daily exposures than allowed under U.S. federal standards. Chlorpyrifos is linked to neurological effects, especially in children, and is still permitted for use on crops. The study,  Indigenous children living nearby plantations with chlorpyrifos-treated bags have elevated 3,5,6-trichloro-2-pyridinol (TCPy) urinary concentrations, was lead by Berna van Wendel de Joode, PhD  (Central American Institute for Studies on Toxic Substances (IRET), Universidad Nacional, Heredia, Costa Rica). It was conducted in Costa Rica’s banana and plantain plantations in the Talamanca region, and  targeted villages situated nearby to the plantations where blue bags treated with chlorpyrifos are routinely used to protect banana and plantain crops from pests. Two villages under study are near plantations that use chlorpyrifos-treated bags, while the organic village is near several plantations  that use little or no insecticide. For 140 children, aged 6 — 9, mostly indigenous Ngäbe and Bribri, parent-interviews and urine samples were obtained. Chlorpyrifos’ environmental levels […]

(Beyond Pesticides, November 27, 2012) On Monday, the American Academy of Pediatrics (AAP) released a landmark policy statement, Pesticide Exposure in Children, and an accompanying technical report on the effects of pesticide exposure in children. In the documents, released in the December 2012 issue of Pediatrics magazine and online on November 26, AAP makes note of the current shortfalls in medical training, public health tracking, and regulatory action on pesticides. Acknowledging the risks to children from both acute and chronic effects, AAP’s report provides recommendations to both pediatricians and government health agencies. AAP’s policy statement comes on the heels of an October 2012 report citing the benefits of eating organic food in order to reduce pesticide exposure. Lead authors on the documents for the AAP’s Council on Environmental Health are James R. Roberts, MD, MPH, Medical University of South Carolina, and Catherine J. Karr, MD, PhD, University of Washington. AAP’s statement notes that, “Children encounter pesticides daily and have unique susceptibilities to their potential toxicity.” The report discusses how kids are exposed to pesticides every day in air, food, dust, and soil. Children also frequently come into contact with pesticide residue on pets and after lawn, garden, or household pesticide […]

(Beyond Pesticides, October 4, 2012) The Centers for Disease Control and Prevention (CDC) has released updated tables for its Fourth National Report on Human Exposure to Environmental Chemicals, which was released in 2009. The new data includes updated tables for 119 chemicals and tables for 34 new chemicals, including updates for 2,4-D and triclosan and their metabolites. New metabolites of organophosphorous insecticides are added for the first time. Notably, the report found that concentrations of four metabolites of organophosphates generally increased among nearly all groups CDC measured, while levels for two generally decreased. Organophosphate pesticides, such as chlorpyrifos, are highly toxic to humans and the environment. Chlorpyrifos is a frequent water contaminant and a long range toxicant, exposing communities and polluting pristine areas far from where it was applied. Volatilization drift ””the evaporation of the pesticide after application”” is also part of the problem for chlorpyrifos. A 2009 study found the pesticide to have significant impacts on the growth and development of amphibians miles away from the site where it was first applied. A USGS study in 2007 concludes that the breakdown products of chlorpyrifos are up to 100 times more toxic than the original. The Updated Tables, September 2012, […]

(Beyond Pesticides, September 12, 2012) Expectant mothers exposed to the pesticide additive piperonyl butoxide (PBO), widely used in synthetic prethroid insecticides and those ending in “thrin” (popular in mosquito spray programs), during pregnancy pass to their children a heightened risk of noninfectious cough at ages 5 and 6, according to researchers at the Columbia Center for Children’s Environmental Health (CCCEH). These findings support the premise that children’s respiratory system is susceptible to damage from toxic exposures during the prenatal period. Researchers outfitted 224 expectant mothers with air monitors during their third trimester of pregnancy and measured the levels of PBO and permethrin in the air around them. Then, once the children were 5 and 6, the same two chemicals were measured from air samples collected inside their home. Results showed that children exposed to PBO in the womb were at increased odds of reporting cough unrelated to cold or flu. Researchers found no correlation between prenatal or childhood exposure to permethrin, however they pointed out that this may be because PBO is easier to measure in air samples than permethrin. Coauthor of the study, “Prenatal exposure to pesticide ingredient piperonyl butoxide and childhood cough in an urban cohort,” Dr. Rachel […]

(Beyond Pesticides, October 14, 2011) Researchers at Uppsala University in Sweden have found that environmental toxicants such as dioxins, PCBs, and pesticides can pose a risk for cardiovascular disease. The results of the study, entitled “Circulating Levels of Persistent Organic Pollutants (POPs) and Carotid Atherosclerosis in the Elderly,” show a link between exposure to persistent organic pollutants (POPs), including several organochlorine pesticides, and the development of atherosclerosis, which can lead to heart disease. The study will be published in the journal Environmental Health Perspectives, and a version of it is available online ahead of print. Cardiovascular diseases, including heart attacks and strokes, are the most common cause of death in industrialized countries, and the most important underlying cause of these diseases is atherosclerosis. Unbalanced blood fats, diabetes, smoking, and high blood pressure are traditionally recognized risk factors for atherosclerosis. Previous studies have also reported possible links between cardiovascular disease and high levels of persistent (long-lived and hard-to-degrade) organic environmental toxicants, such as dioxins, polychlorinated biphenyls (PCBs), and pesticides. These compounds are fat-soluble and can therefore accumulate in vessel walls. However, no earlier studies have investigated possible links between exposure to these compounds and atherosclerosis. Of the POPs that were screened […]

(Beyond Pesticides, June 20, 2011) In a study published this week in the journal Pediatrics, researchers report findings that link mothers’ exposure to organochlorine pesticides during pregnancy with infants’ sizes at birth. The trend shows that the more mothers are exposed to the pesticides during pregnancy, the higher the chances are for reduced birth weight and length of their newborns. Comprising a total of 494 women and infants in Valencia, Spain from the years 2003-2006, the study evaluates umbilical cord blood for residues of four pesticides or pesticide degradates: DDT, DDE, hexachlorobenzene (HCB), and beta-hexachlorocyclohexane. The results show that a 10-fold increase in pesticide concentrations in the blood corresponds to a reduction in birth weight of 2-4 ounces. Additional results are correlated to specific pesticides. Higher concentrations of DDT results in a reduction in head circumference of 0.26cm, which the researchers call a “significant decrease.” Additionally, a decrease of 0.39cm in birth length is correlated with each 10-fold increase in concentration of HCB. The researchers note several concerns related to the findings, aside from the results themselves. Since people are exposed to a wide variety of chemicals in general throughout their everyday lives, higher pesticide exposure could betray higher exposure […]

(Beyond Pesticides, May 12, 2011) Beyond Pesticides joined 112 organizations in endorsing a 102-page set of environmental right-to-know recommendations, which OMB Watch presented on Tuesday, May 10 to the Obama administration. The recommendations, collaboratively drafted by advocates from across the country, aim to expand access to environmental information, equip citizens with data about their environmental health, and empower Americans to protect themselves, their families, and their communities from toxic pollution. The recommendations are contained within a report titled An Agenda to Strengthen Our Right to Know: Empowering Citizens with Environmental, Health, and Safety Information, drafted as part of the Environmental Information Initiative project. OMB Watch compiled the report following a year of work that culminated in a conference of almost 100 environmental, health, and safety advocates held in November 2010. Sean Moulton, OMB Watch’s Director of Federal Information Policy, said, “Many of the recommendations laid out in the report are ambitious, but they are also needed. Environmental and right-to-know advocates believe that much more information, presented in more searchable and usable formats, is necessary in order to adequately protect Americans’ environmental health.” Three key priorities are woven throughout the recommendations: 1. Environmental justice must always be considered — Minority and […]

(Beyond Pesticides, February 9, 2010) In an innovative development that could transform the way Americans view the origins of learning and developmental disabilities, the national Learning and Developmental Disabilities Initiative (LDDI) released the first-ever biomonitoring report identifying toxic chemical pollution in people from the learning and developmental disability community. Mind, Disrupted: How Toxic Chemicals May Affect How We Think and Who We Are examines 61 toxic chemicals present in project participants in the context of rising rates of autism, attention-deficit hyperactivity disorder, and other learning and developmental disabilities.   In the U. S., 5-15% of children under age 18 are affected by learning and developmental disabilities. Reported cases of autism spectrum disorders have increased tenfold since the early 1990s. Based on current research, the Centers for Disease Control and Prevention (CDC) states that 1 in 110 eight-year-old children have autism in the United States. Mind, Disrupted measured levels of a set of neurotoxic and endocrine-disrupting chemicals in the participants’ bodies. A growing body of peer-reviewed scientific research, including animal and human studies, shows that these chemicals can disrupt the development and functioning of the brain and nervous system. Eleven of the twelve study participants had detectable levels of triclosan in […]

(Beyond Pesticides, October 13, 2009) In a first ever investigation of toxic chemicals found in the bodies of doctors and nurses, Physicians for Social Responsibility (PSR) in partnership with American Nurses Association (ANA) and Health Care Without Harm (HCWH) released the Hazardous Chemicals In Health Care report on October 8th. The inquiry found that all of the 20 participants had toxic chemicals associated with health care in their bodies. Each participant had at least 24 individual chemicals present, four of which are on the recently released US Environmental Protection Agency (EPA) list of priority chemicals for regulation. These chemicals are all associated with chronic illness and physical disorders. The Hazardous Chemicals in Health Care report offers preliminary indicators of what the broader health care community may be experiencing. The project tested for 62 distinct chemicals in six categories: bisphenol A, mercury, perflourinated compounds, phthalates, polybrominated diphenyl ethers, and triclosan. The chemicals tested in the investigation are used in products common to the health care setting, from baby bottles, hand sanitizer, and medical gauges, to industrial paints, IV bags and tubes and stain-resistant clothing. Twelve doctors and eight nurses, two in each of 10 states were tested for the presence of […]

(Beyond Pesticides, September 17, 2009) Last week, the Centers for Disease Control and Prevention (CDC) awarded $5 million to the states of California, New York and Washington to conduct biomonitoring surveys to assess public exposure to chemicals and toxic substances. This will allow the states to determine which environmental chemicals people have been exposed to and how much of those chemicals are in their bodies. Many U.S. residents carry toxic pesticides in their bodies above government assessed “acceptable” levels. Biomonitoring, which measures levels of chemicals directly in people’s blood or urine, has become increasingly helpful for assessing people’s exposure to toxic substances as well as for responding to serious environmental public health problems. The PANNA report “Chemical Trespass: Pesticides in Our Bodies and Corporate Accountability” in 2004, which compiled data from previous CDC biomonitoring surveys found that children, women and Mexican Americans carried the heaviest “pesticide body burden.” Another biomonitoring study by the World Wildlife Fund UK in 2003, revealed that chemicals, such as DDT, which have been banned for decades and are associated with cancer, immune system disorders, and other health problems, are still found in people today. “Biomonitoring measurements are considered the most health-relevant assessments of exposure because […]

(Beyond Pesticides, February 24, 2009) NIEHS staff scientist Freya Kamel, Ph.D., Harvard School of Public Health professor Chensheng (Alex) Lu, Ph.D., and Wake Forest University’s Center for Worker Health director Thomas Arcury, Ph.D. will speak as Science and Health panelists at Bridge to an Organic Future: Opportunities for health and the environment, the 27th National Pesticide Forum, April 3-4 in Carrboro, NC. Freya Kamel, Ph.D. Freya Kamel’s research interests focus on environmental determinants of neurologic dysfunction and disease, in particular, neurodegenerative disease. Dr. Kamel and her colleagues at the National Institute for Environmental Health Sciences (NIEHS) of the National Institutes of Health (NIH) examined the relationship of farm work-related exposures to subclinical neurobehavioral deficits in farmworkers. Deficits in neurobehavioral performance reflecting cognitive and psychomotor function related to the duration of work experience were seen in former as well as current farmworkers, and decreased performance was related to chronic exposure even in the absence of a history of pesticide poisoning. Thus, long-term experience of farm work is associated with measurable deficits in cognitive and psychomotor function. Dr. Kamel participated in work on the Agricultural Health Study (AHS), a large cohort study of licensed pesticide applicators and their spouses in Iowa and […]

(Beyond Pesticides, October 20, 2008) Organophosphate (OP) pesticides are among a toxic soup of hazardous chemicals found in the bodies of pregnant women, according to an National Institutes of Environmental Health Sciences (NIEHS) led study doi:10.1016/j.envres.2008.07.014 published in the October issue of the journal Environmental Research. The population-based birth cohort study analyzed urine specimens of one hundred pregnant women. The study builds on the existing body of evidence that shows that low-level exposure to chemicals impact human health, especially pregnant women and their children. The research is part of the Generation R Study, which includes 9778 participants in the Netherlands and focuses on growth and physical development, behavioral and cognitive development, childhood diseases and health, and health care for pregnant women and children. The Generation R Study allows the researchers to follow-up with the study participants and “provides an opportunity to efficiently address questions regarding the reproductive and development effects of prenatal exposures.” Besides finding high levels of OP pesticides, the researchers find some suspected endocrine disrupting compounds including bisphenol A (BPA) and phthalates. Animal studies show that these chemicals can affect brain and reproductive development. According to the researchers, exposure to OP pesticides and some phthalates were significantly higher […]